Nature nanotechnology最新文献_第2页

Ferrimagnetic Heusler tunnel junctions with fast spin-transfer torque switching enabled by low magnetization 具有快速自旋传递转矩开关的铁磁赫斯勒隧道结，可通过低磁化实现

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-01-03 DOI: 10.1038/s41565-024-01827-7

Chirag Garg, Panagiotis Ch. Filippou, Ikhtiar, Yari Ferrante, See-Hun Yang, Brian Hughes, Charles T. Rettner, Timothy Phung, Sergey Faleev, Teya Topuria, Mahesh G. Samant, Jaewoo Jeong, Stuart S. P. Parkin

{"title":"Ferrimagnetic Heusler tunnel junctions with fast spin-transfer torque switching enabled by low magnetization","authors":"Chirag Garg, Panagiotis Ch. Filippou, Ikhtiar, Yari Ferrante, See-Hun Yang, Brian Hughes, Charles T. Rettner, Timothy Phung, Sergey Faleev, Teya Topuria, Mahesh G. Samant, Jaewoo Jeong, Stuart S. P. Parkin","doi":"10.1038/s41565-024-01827-7","DOIUrl":"https://doi.org/10.1038/s41565-024-01827-7","url":null,"abstract":"Magnetic random-access memory that uses magnetic tunnel junction memory cells is a high-performance, non-volatile memory technology that goes beyond traditional charge-based memories. Today, its speed is limited by the high magnetization of the memory storage layer. Here we prepare magnetic tunnel junction memory devices with a low magnetization ferrimagnetic Heusler alloy Mn3Ge as the memory storage layer on technologically relevant amorphous substrates using a combination of a nitride seed layer and a chemical templating layer. We switch the magnetic state of the storage layer with nanosecond long write pulses at a reliable write error rate of 10−7 and detect a tunnelling magnetoresistance of 87% at ambient temperature. These results provide a strategy towards lower write switching currents using ferrimagnetic Heusler materials and, therefore, to the scaling of high-performance magnetic random-access memories beyond those nodes possible with ferromagnetic memory layers.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"17 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AND-gated protease-activated nanosensors for programmable detection of anti-tumour immunity 用于可编程检测抗肿瘤免疫的and门控蛋白酶激活纳米传感器

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-01-03 DOI: 10.1038/s41565-024-01834-8

Anirudh Sivakumar, Hathaichanok Phuengkham, Hitha Rajesh, Quoc D. Mac, Leonard C. Rogers, Aaron D. Silva Trenkle, Swapnil Subhash Bawage, Robert Hincapie, Zhonghan Li, Sofia Vainikos, Inho Lee, Min Xue, Peng Qiu, M. G. Finn, Gabriel A. Kwong

{"title":"AND-gated protease-activated nanosensors for programmable detection of anti-tumour immunity","authors":"Anirudh Sivakumar, Hathaichanok Phuengkham, Hitha Rajesh, Quoc D. Mac, Leonard C. Rogers, Aaron D. Silva Trenkle, Swapnil Subhash Bawage, Robert Hincapie, Zhonghan Li, Sofia Vainikos, Inho Lee, Min Xue, Peng Qiu, M. G. Finn, Gabriel A. Kwong","doi":"10.1038/s41565-024-01834-8","DOIUrl":"https://doi.org/10.1038/s41565-024-01834-8","url":null,"abstract":"The forward design of biosensors that implement Boolean logic to improve detection precision primarily relies on programming genetic components to control transcriptional responses. However, cell- and gene-free nanomaterials programmed with logical functions may present lower barriers for clinical translation. Here we report the design of activity-based nanosensors that implement AND-gate logic without genetic parts via bi-labile cyclic peptides. These actuate by releasing a reporter if and only if cleaved by a specific pair of proteases. AND-gated nanosensors that detect the concomitant activity of the granzyme B protease secreted by CD8 T cells and matrix metalloproteinases overexpressed by cancer cells identify the unique condition of cytotoxic T cell killing of tumour cells. In preclinical mouse models, AND-gated nanosensors discriminate tumours that are responsive to immune checkpoint blockade therapy from B2m–/– tumours that are resistant to it, minimize signals from tissues without co-localized protease expression including the lungs during acute influenza infection, and release a reporter locally in tissue or distally in the urine for facile detection.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"70 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autophagosomes coated in situ with nanodots act as personalized cancer vaccines 纳米点包裹的自噬体可作为个体化癌症疫苗

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-01-03 DOI: 10.1038/s41565-024-01826-8

Wei-Qiang Huang, Wei You, Ya-Qi Zhu, Fan Gao, Zhi-Zhi Wu, Guang Chen, Jun Xiao, Qi Shao, Long-Hai Wang, Xuan Nie, Ze Zhang, Chun-Yan Hong, Ye-Zi You

引用次数: 0

Measuring age-dependent viscoelasticity of organelles, cells and organisms with time-shared optical tweezer microrheology 用分时光学镊子微流变学测量细胞器、细胞和生物体的年龄依赖性粘弹性

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-01-02 DOI: 10.1038/s41565-024-01830-y

Frederic Català-Castro, Santiago Ortiz-Vásquez, Carmen Martínez-Fernández, Fabio Pezzano, Carla Garcia-Cabau, Martín Fernández-Campo, Neus Sanfeliu-Cerdán, Senda Jiménez-Delgado, Xavier Salvatella, Verena Ruprecht, Paolo-Antonio Frigeri, Michael Krieg

{"title":"Measuring age-dependent viscoelasticity of organelles, cells and organisms with time-shared optical tweezer microrheology","authors":"Frederic Català-Castro, Santiago Ortiz-Vásquez, Carmen Martínez-Fernández, Fabio Pezzano, Carla Garcia-Cabau, Martín Fernández-Campo, Neus Sanfeliu-Cerdán, Senda Jiménez-Delgado, Xavier Salvatella, Verena Ruprecht, Paolo-Antonio Frigeri, Michael Krieg","doi":"10.1038/s41565-024-01830-y","DOIUrl":"https://doi.org/10.1038/s41565-024-01830-y","url":null,"abstract":"Quantifying the mechanical response of the biological milieu (such as the cell’s interior) and complex fluids (such as biomolecular condensates) would enable a better understanding of cellular differentiation and aging and accelerate drug discovery. Here we present time-shared optical tweezer microrheology to determine the frequency- and age-dependent viscoelastic properties of biological materials. Our approach involves splitting a single laser beam into two near-instantaneous time-shared optical traps to carry out simultaneous force and displacement measurements and quantify the mechanical properties ranging from millipascals to kilopascals across five decades of frequency. To create a practical and robust nanorheometer, we leverage both numerical and analytical models to analyse typical deviations from the ideal behaviour and offer solutions to account for these discrepancies. We demonstrate the versatility of the technique by measuring the liquid–solid phase transitions of MEC-2 stomatin and CPEB4 biomolecular condensates, and quantify the complex viscoelastic properties of intracellular compartments of zebrafish progenitor cells. In Caenorhabditis elegans, we uncover how mutations in the nuclear envelope proteins LMN-1 lamin A, EMR-1 emerin and LEM-2 LEMD2, which cause premature aging disorders in humans, soften the cytosol of intestinal cells during organismal age. We demonstrate that time-shared optical tweezer microrheology offers the rapid phenotyping of material properties inside cells and protein blends, which can be used for biomedical and drug-screening applications.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Half-wave nanolasers and intracellular plasmonic lasing particles 半波纳米激光器与细胞内等离子体激光粒子

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-01-02 DOI: 10.1038/s41565-024-01843-7

Sangyeon Cho, Nicola Martino, Seok-Hyun Yun

{"title":"Half-wave nanolasers and intracellular plasmonic lasing particles","authors":"Sangyeon Cho, Nicola Martino, Seok-Hyun Yun","doi":"10.1038/s41565-024-01843-7","DOIUrl":"https://doi.org/10.1038/s41565-024-01843-7","url":null,"abstract":"The ultimate limit for laser miniaturization would be achieving lasing action in the lowest-order cavity mode within a device volume of ≤(λ/2n)3, where λ is the free-space wavelength and n is the refractive index. Here we highlight the equivalence of localized surface plasmons and surface plasmon polaritons within resonant systems, introducing nanolasers that oscillate in the lowest-order localized surface plasmon or, equivalently, half-cycle surface plasmon polariton. These diffraction-limited single-mode emitters, ranging in size from 170 to 280 nm, harness strong coupling between gold and InxGa1−xAs1−yPy in the near-infrared (λ = 1,000–1,460 nm), away from the surface plasmon frequency. This configuration supports only the lowest-order dipolar mode within the semiconductor’s broad gain bandwidth. A quasi-continuous-level semiconductor laser model explains the lasing dynamics under optical pumping. In addition, we fabricate isolated gold-coated semiconductor discs and demonstrate higher-order lasing within live biological cells. These plasmonic nanolasers hold promise for multi-colour imaging and optical barcoding in cellular applications.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"351 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Negative memory capacitance and ionic filtering effects in asymmetric nanopores 非对称纳米孔中的负记忆电容和离子过滤效应

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-01-02 DOI: 10.1038/s41565-024-01829-5

Nasim Farajpour, Y. M. Nuwan D. Y. Bandara, Lauren Lastra, Kevin J. Freedman

{"title":"Negative memory capacitance and ionic filtering effects in asymmetric nanopores","authors":"Nasim Farajpour, Y. M. Nuwan D. Y. Bandara, Lauren Lastra, Kevin J. Freedman","doi":"10.1038/s41565-024-01829-5","DOIUrl":"https://doi.org/10.1038/s41565-024-01829-5","url":null,"abstract":"The pervasive model for a solvated, ion-filled nanopore is often a resistor in parallel with a capacitor. For conical nanopore geometries, here we propose the inclusion of a Warburg-like element, which is necessary to explain otherwise anomalous observations such as negative capacitance and low-pass filtering of translocation events (we term this phenomenon as Warburg filtering). The negative capacitance observed here has long equilibration times and memory (that is, mem-capacitance) at negative voltages. We used the transient occlusion of the pore using λ-DNA and 10 kbp DNA to test whether events are being attenuated by purely ionic phenomena when there is sufficient amplifier bandwidth. We argue here that both phenomena can be explained by the inclusion of the Warburg-like element, which is mechanistically linked to concentration polarization and activation energy to generate and maintain localized concentration gradients. We conclude the study with insights into the transduction of molecular translocations into electrical signals, which is not simply based on pulse-like resistance changes but instead on the complex and nonlinear storage of ions that enter dis-equilibrium during molecular transit.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"72 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Momentum tunnelling between nanoscale liquid flows 纳米级液体流动之间的动量隧穿

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-01-02 DOI: 10.1038/s41565-024-01842-8

Baptiste Coquinot, Anna T. Bui, Damien Toquer, Angelos Michaelides, Nikita Kavokine, Stephen J. Cox, Lydéric Bocquet

{"title":"Momentum tunnelling between nanoscale liquid flows","authors":"Baptiste Coquinot, Anna T. Bui, Damien Toquer, Angelos Michaelides, Nikita Kavokine, Stephen J. Cox, Lydéric Bocquet","doi":"10.1038/s41565-024-01842-8","DOIUrl":"https://doi.org/10.1038/s41565-024-01842-8","url":null,"abstract":"The world of nanoscales in fluidics is the frontier where the continuum of fluid mechanics meets the atomic, and even quantum, nature of matter. While water dynamics remains largely classical under extreme confinement, several experiments have recently reported coupling between water transport and the electronic degrees of freedom of the confining materials. This avenue prompts us to reconsider nanoscale hydrodynamic flows under the perspective of interacting excitations, akin to condensed matter frameworks. Here we show, using a combination of many-body theory and molecular simulations, that the flow of a liquid can induce the flow of another liquid behind a separating wall, at odds with the prediction of continuum hydrodynamics. We further show that the range of this ‘flow tunnelling’ can be tuned through the solid’s electronic excitations, with a maximum occurring when these are at resonance with the liquid’s charge density fluctuations. Flow tunnelling is expected to play a role in global transport across nanoscale fluidic networks, such as lamellar graphene oxide or MXene membranes. It further suggests exploiting the electronic properties of the confining walls for manipulating liquids via their dielectric spectra, beyond the nature and characteristics of individual molecules.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"831 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renewable hydrogen is having a moment 可再生氢正大行其道

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2024-12-23 DOI: 10.1038/s41565-024-01838-4

Katherine Bourzac

引用次数: 0

Solar cells for stored energy 储存能量的太阳能电池

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2024-12-23 DOI: 10.1038/s41565-024-01837-5

Dirk Eidemüller

引用次数: 0

The challenge of studying interfaces in battery materials 研究电池材料界面的挑战