Nature nanotechnology最新文献

{"title":"Direct catalytic plastics waste upcycling","authors":"","doi":"10.1038/s41565-023-01473-5","DOIUrl":"10.1038/s41565-023-01473-5","url":null,"abstract":"Recycling plastics waste into value-added chemicals using efficient and selective novel nanocatalysts promises economic as well as environmental benefits.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"18 7","pages":"687-687"},"PeriodicalIF":38.3,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41565-023-01473-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10207242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA-origami-directed virus capsid polymorphism","authors":"Iris Seitz, Sharon Saarinen, Esa-Pekka Kumpula, Donna McNeale, Eduardo Anaya-Plaza, Vili Lampinen, Vesa P. Hytönen, Frank Sainsbury, Jeroen J. L. M. Cornelissen, Veikko Linko, Juha T. Huiskonen, Mauri A. Kostiainen","doi":"10.1038/s41565-023-01443-x","DOIUrl":"10.1038/s41565-023-01443-x","url":null,"abstract":"Viral capsids can adopt various geometries, most iconically characterized by icosahedral or helical symmetries. Importantly, precise control over the size and shape of virus capsids would have advantages in the development of new vaccines and delivery systems. However, current tools to direct the assembly process in a programmable manner are exceedingly elusive. Here we introduce a modular approach by demonstrating DNA-origami-directed polymorphism of single-protein subunit capsids. We achieve control over the capsid shape, size and topology by employing user-defined DNA origami nanostructures as binding and assembly platforms, which are efficiently encapsulated within the capsid. Furthermore, the obtained viral capsid coatings can shield the encapsulated DNA origami from degradation. Our approach is, moreover, not limited to a single type of capsomers and can also be applied to RNA–DNA origami structures to pave way for next-generation cargo protection and targeting strategies. DNA and RNA origami nanostructures direct the size, shape and topology of different virus capsids in a user-defined manner while shielding encapsulated origamis from degradation.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"18 10","pages":"1205-1212"},"PeriodicalIF":38.3,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9830062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasmonic structural colour paint gets commercial attention","authors":"Alberto Moscatelli","doi":"10.1038/s41565-023-01469-1","DOIUrl":"10.1038/s41565-023-01469-1","url":null,"abstract":"","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"18 7","pages":"703-703"},"PeriodicalIF":38.3,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10119426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the enhanced antitumour potency of STING agonist after conjugation to polymer nanoparticles","authors":"Pere Dosta, Alexander M. Cryer, Michelle Z. Dion, Tsubasa Shiraishi, Steven P. Langston, David Lok, Jianing Wang, Sean Harrison, Tiquella Hatten, Michelle L. Ganno, Vicky A. Appleman, Gonzalo Muñoz Taboada, Núria Puigmal, Shiran Ferber, Santhosh Kalash, Michaela Prado, Alma L. Rodríguez, Walid S. Kamoun, Adnan O. Abu-Yousif, Natalie Artzi","doi":"10.1038/s41565-023-01447-7","DOIUrl":"10.1038/s41565-023-01447-7","url":null,"abstract":"Intravenously administered cyclic dinucleotides and other STING agonists are hampered by low cellular uptake and poor circulatory half-life. Here we report the covalent conjugation of cyclic dinucleotides to poly(β-amino ester) nanoparticles through a cathepsin-sensitive linker. This is shown to increase stability and loading, thereby expanding the therapeutic window in multiple syngeneic tumour models, enabling the study of how the long-term fate of the nanoparticles affects the immune response. In a melanoma mouse model, primary tumour clearance depends on the STING signalling by host cells—rather than cancer cells—and immune memory depends on the spleen. The cancer cells act as a depot for the nanoparticles, releasing them over time to activate nearby immune cells to control tumour growth. Collectively, this work highlights the importance of nanoparticle structure and nano-biointeractions in controlling immunotherapy efficacy. STING agonists are often limited by low circulation time and cellular uptake. The conjugation of STING agonists with polymer nanoparticles is shown to enhance stability, circulation time and cellular uptake, increasing the immunotherapeutic activity.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"18 11","pages":"1351-1363"},"PeriodicalIF":38.3,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9926723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The sum of symmetries is lower than its parts","authors":"Paul Seifert, Christoph Kastl","doi":"10.1038/s41565-023-01427-x","DOIUrl":"10.1038/s41565-023-01427-x","url":null,"abstract":"A Berry curvature dipole can be generated at certain symmetry-mismatched van der Waals hetero-interfaces even though each material has no Berry curvature dipole in its band structure.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"18 8","pages":"844-845"},"PeriodicalIF":38.3,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9995239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain","authors":"Miguel R. Chuapoco, Nicholas C. Flytzanis, Nick Goeden, J. Christopher Octeau, Kristina M. Roxas, Ken Y. Chan, Jon Scherrer, Janet Winchester, Roy J. Blackburn, Lillian J. Campos, Kwun Nok Mimi Man, Junqing Sun, Xinhong Chen, Arthur Lefevre, Vikram Pal Singh, Cynthia M. Arokiaraj, Timothy F. Shay, Julia Vendemiatti, Min J. Jang, John K. Mich, Yemeserach Bishaw, Bryan B. Gore, Victoria Omstead, Naz Taskin, Natalie Weed, Boaz P. Levi, Jonathan T. Ting, Cory T. Miller, Benjamin E. Deverman, James Pickel, Lin Tian, Andrew S. Fox, Viviana Gradinaru","doi":"10.1038/s41565-023-01419-x","DOIUrl":"10.1038/s41565-023-01419-x","url":null,"abstract":"Crossing the blood–brain barrier in primates is a major obstacle for gene delivery to the brain. Adeno-associated viruses (AAVs) promise robust, non-invasive gene delivery from the bloodstream to the brain. However, unlike in rodents, few neurotropic AAVs efficiently cross the blood–brain barrier in non-human primates. Here we report on AAV.CAP-Mac, an engineered variant identified by screening in adult marmosets and newborn macaques, which has improved delivery efficiency in the brains of multiple non-human primate species: marmoset, rhesus macaque and green monkey. CAP-Mac is neuron biased in infant Old World primates, exhibits broad tropism in adult rhesus macaques and is vasculature biased in adult marmosets. We demonstrate applications of a single, intravenous dose of CAP-Mac to deliver functional GCaMP for ex vivo calcium imaging across multiple brain areas, or a cocktail of fluorescent reporters for Brainbow-like labelling throughout the macaque brain, circumventing the need for germline manipulations in Old World primates. As such, CAP-Mac is shown to have potential for non-invasive systemic gene transfer in the brains of non-human primates. Crossing the blood–brain barrier in primates is a major obstacle to gene delivery in the brain. Here an adeno-associated virus variant (AAV.CAP-Mac) is identified and demonstrated for crossing the blood–brain barrier and delivering gene sequences to the brain of different non-human primates species.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"18 10","pages":"1241-1251"},"PeriodicalIF":38.3,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10575780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10348352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sign reversal of the Josephson inductance magnetochiral anisotropy and 0–π-like transitions in supercurrent diodes","authors":"A. Costa, C. Baumgartner, S. Reinhardt, J. Berger, S. Gronin, G. C. Gardner, T. Lindemann, M. J. Manfra, J. Fabian, D. Kochan, N. Paradiso, C. Strunk","doi":"10.1038/s41565-023-01451-x","DOIUrl":"10.1038/s41565-023-01451-x","url":null,"abstract":"The recent discovery of the intrinsic supercurrent diode effect, and its prompt observation in a rich variety of systems, has shown that non-reciprocal supercurrents naturally emerge when both space-inversion and time-inversion symmetries are broken. In Josephson junctions, non-reciprocal supercurrent can be conveniently described in terms of spin-split Andreev states. Here we demonstrate a sign reversal of the Josephson inductance magnetochiral anisotropy, a manifestation of the supercurrent diode effect. The asymmetry of the Josephson inductance as a function of the supercurrent allows us to probe the current–phase relation near equilibrium, and to probe jumps in the junction ground state. Using a minimal theoretical model, we can then link the sign reversal of the inductance magnetochiral anisotropy to the so-called 0−π-like transition, a predicted but still elusive feature of multichannel junctions. Our results demonstrate the potential of inductance measurements as sensitive probes of the fundamental properties of unconventional Josephson junctions. A sudden inversion of the supercurrent diode effect is revealed in both inductance and critical current measurements in ballistic Josephson junctions. A simple analytical model shows that the inversion is associated with a ground state jump, the elusive 0−π-like transition.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"18 11","pages":"1266-1272"},"PeriodicalIF":38.3,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10143806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photomechanical molecular machines enable control of cell signalling","authors":"","doi":"10.1038/s41565-023-01437-9","DOIUrl":"10.1038/s41565-023-01437-9","url":null,"abstract":"Intercellular calcium waves (ICW) are mechanosensitive signalling phenomena that coordinate cellular responses in key physiological processes. The force applied by light-activated molecular machines is shown to remotely stimulate ICW. The ICW induced by these molecular machines can be exploited to regulate downstream functions, such as muscle contraction, in vitro and in vivo.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"18 9","pages":"979-980"},"PeriodicalIF":38.3,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10645944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular machines stimulate intercellular calcium waves and cause muscle contraction","authors":"Jacob L. Beckham, Alexis R. van Venrooy, Soonyoung Kim, Gang Li, Bowen Li, Guillaume Duret, Dallin Arnold, Xuan Zhao, John T. Li, Ana L. Santos, Gautam Chaudhry, Dongdong Liu, Jacob T. Robinson, James M. Tour","doi":"10.1038/s41565-023-01436-w","DOIUrl":"10.1038/s41565-023-01436-w","url":null,"abstract":"Intercellular calcium waves (ICW) are complex signalling phenomena that control many essential biological activities, including smooth muscle contraction, vesicle secretion, gene expression and changes in neuronal excitability. Accordingly, the remote stimulation of ICW could result in versatile biomodulation and therapeutic strategies. Here we demonstrate that light-activated molecular machines (MM)—molecules that perform mechanical work on the molecular scale—can remotely stimulate ICW. MM consist of a polycyclic rotor and stator that rotate around a central alkene when activated with visible light. Live-cell calcium-tracking and pharmacological experiments reveal that MM-induced ICW are driven by the activation of inositol-triphosphate-mediated signalling pathways by unidirectional, fast-rotating MM. Our data suggest that MM-induced ICW can control muscle contraction in vitro in cardiomyocytes and animal behaviour in vivo in Hydra vulgaris. This work demonstrates a strategy for directly controlling cell signalling and downstream biological function using molecular-scale devices. Intercellular calcium waves drive numerous biological processes. Here light-activated molecular machines that—via nanomechanical action—stimulate ICW are reported, opening up avenues for the modulation of downstream biological processes using molecular-scale devices.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"18 9","pages":"1051-1059"},"PeriodicalIF":38.3,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10645941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium","authors":"Joke Deprez, Rein Verbeke, Sofie Meulewaeter, Ilke Aernout, Heleen Dewitte, Tine Decruy, Julie Coudenys, Julie Van Duyse, Gert Van Isterdael, Dan Peer, Roy van der Meel, Stefaan C. De Smedt, Peggy Jacques, Dirk Elewaut, Ine Lentacker","doi":"10.1038/s41565-023-01444-w","DOIUrl":"10.1038/s41565-023-01444-w","url":null,"abstract":"The therapeutic potential of liposomes to deliver drugs into inflamed tissue is well documented. Liposomes are believed to largely transport drugs into inflamed joints by selective extravasation through endothelial gaps at the inflammatory sites, known as the enhanced permeation and retention effect. However, the potential of blood-circulating myeloid cells for the uptake and delivery of liposomes has been largely overlooked. Here we show that myeloid cells can transport liposomes to inflammatory sites in a collagen-induced arthritis model. It is shown that the selective depletion of the circulating myeloid cells reduces the accumulation of liposomes up to 50–60%, suggesting that myeloid-cell-mediated transport accounts for more than half of liposomal accumulation in inflamed regions. Although it is widely believed that PEGylation inhibits premature liposome clearance by the mononuclear phagocytic system, our data show that the long blood circulation times of PEGylated liposomes rather favours uptake by myeloid cells. This challenges the prevailing theory that synovial liposomal accumulation is primarily due to the enhanced permeation and retention effect and highlights the potential for other pathways of delivery in inflammatory diseases. PEGylated liposomal accumulation in inflamed regions has mainly been attributed to the enhanced permeation and retention effect. An arthritis model that chemotactically attracted myeloid cells shows that monocytes and neutrophils play an essential role in liposome delivery towards inflamed joints.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"18 11","pages":"1341-1350"},"PeriodicalIF":38.3,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10143805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}