Nature nanotechnology最新文献_第10页

Long-term blood sugar control with smart insulin crystals 智能胰岛素晶体长期血糖控制

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-02-26 DOI: 10.1038/s41565-025-01871-x

引用次数: 0

Nanoscopic cross-grain cation homogenization in perovskite solar cells 钙钛矿太阳能电池的纳米级交叉颗粒阳离子均匀化

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-02-24 DOI: 10.1038/s41565-025-01854-y

Mingwei Hao, Jonghee Yang, Wenjian Yu, Benjamin J. Lawrie, Pengfei Guo, Xiangzhao Zhang, Tianwei Duan, Tong Xiao, Linqi Chen, Yang Xiang, Peijun Guo, Mahshid Ahmadi, Yuanyuan Zhou

{"title":"Nanoscopic cross-grain cation homogenization in perovskite solar cells","authors":"Mingwei Hao, Jonghee Yang, Wenjian Yu, Benjamin J. Lawrie, Pengfei Guo, Xiangzhao Zhang, Tianwei Duan, Tong Xiao, Linqi Chen, Yang Xiang, Peijun Guo, Mahshid Ahmadi, Yuanyuan Zhou","doi":"10.1038/s41565-025-01854-y","DOIUrl":"https://doi.org/10.1038/s41565-025-01854-y","url":null,"abstract":"Multiscale cation inhomogeneity has been a major hurdle in state-of-the-art formamidinium–caesium (FA–Cs) mixed-cation perovskites for achieving perovskite solar cells with optimal power conversion efficiencies and durability. Although the field has attempted to homogenize the overall distributions of FA–Cs in perovskite films from both plan and cross-sectional views, our understanding of grain-to-grain cation inhomogeneity and ability to tailor it—that is, spatially resolving the FA–Cs compositional difference between individual grains down to the nanoscale—are lacking. Here we reveal that as fundamental building blocks of a perovskite film, individual grains exhibit cationic compositions deviating from the prescribed ideal composition, severely limiting the interfacial optoelectronic properties and perovskite layer durability. This performance-limiting nanoscopic factor is linked to thermodynamic-driven morphological grooving, leading to a segmented surface landscape. At the grain triple junctions, grooves form nanoscale groove traps that hinder the mixing of solid-state cations across grains and thus retard inter-grain FA–Cs mixing. By rationally modulating the heterointerfacial energies, we reduced the depth of these nanoscale groove traps by a factor of three, significantly improving cation homogeneity. Perovskite solar cells with shallower nanoscale groove traps demonstrate enhanced power conversion efficiencies (25.62%) and improved stability under various standardized international protocols. Our work highlights the significance of resolving surface nano-morphologies for homogeneous properties of perovskites.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"27 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systemic HER3 ligand-mimicking nanobioparticles enter the brain and reduce intracranial tumour growth 系统模拟HER3配体的纳米生物颗粒进入大脑并减少颅内肿瘤的生长

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-02-21 DOI: 10.1038/s41565-025-01867-7

Felix Alonso-Valenteen, Simoun Mikhael, HongQiang Wang, Jessica Sims, Michael Taguiam, James Teh, Sam Sances, Michelle Wong, Tianxin Miao, Dustin Srinivas, Nelyda Gonzalez-Almeyda, Ryan H. Cho, Romny Sanchez, Kimngan Nguyenle, Erik Serrano, Briana Ondatje, Rebecca L. Benhaghnazar, Harry B. Gray, Zeev Gross, John Yu, Clive N. Svendsen, Ravinder Abrol, Lali K. Medina-Kauwe

{"title":"Systemic HER3 ligand-mimicking nanobioparticles enter the brain and reduce intracranial tumour growth","authors":"Felix Alonso-Valenteen, Simoun Mikhael, HongQiang Wang, Jessica Sims, Michael Taguiam, James Teh, Sam Sances, Michelle Wong, Tianxin Miao, Dustin Srinivas, Nelyda Gonzalez-Almeyda, Ryan H. Cho, Romny Sanchez, Kimngan Nguyenle, Erik Serrano, Briana Ondatje, Rebecca L. Benhaghnazar, Harry B. Gray, Zeev Gross, John Yu, Clive N. Svendsen, Ravinder Abrol, Lali K. Medina-Kauwe","doi":"10.1038/s41565-025-01867-7","DOIUrl":"https://doi.org/10.1038/s41565-025-01867-7","url":null,"abstract":"Crossing the blood–brain barrier (BBB) and reaching intracranial tumours is a clinical challenge for current targeted interventions including antibody-based therapies, contributing to poor patient outcomes. Increased cell surface density of human epidermal growth factor receptor 3 (HER3) is associated with a growing number of metastatic tumour types and is observed on tumour cells that acquire resistance to a growing number of clinical targeted therapies. Here we describe the evaluation of HER3-homing nanobiological particles (nanobioparticles (NBPs)) on such tumours in preclinical models and our discovery that systemic NBPs could be found in the brain even in the absence of such tumours. Our subsequent studies described here show that HER3 is prominently associated with both mouse and human brain endothelium and with extravasation of systemic NBPs in mice and in human-derived BBB chips in contrast to non-targeted agents. In mice, systemically delivered NBPs carrying tumoricidal agents reduced the growth of intracranial triple-negative breast cancer cells, which also express HER3, with improved therapeutic profile compared to current therapies and compared to agents using traditional BBB transport routes. As HER3 associates with a growing number of metastatic tumours, the NBPs described here may offer targeted efficacy especially when such tumours localize to the brain.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intermediate-range solvent templating and counterion behaviour at charged carbon nanotube surfaces 中范围溶剂模板和反离子行为在带电碳纳米管表面

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-02-21 DOI: 10.1038/s41565-025-01865-9

Camilla Di Mino, Thomas F. Headen, Nadir S. Basma, David J. Buckley, Patrick L. Cullen, Martin C. Wilding, Milo S. P. Shaffer, Neal T. Skipper, Adam J. Clancy, Christopher A. Howard

{"title":"Intermediate-range solvent templating and counterion behaviour at charged carbon nanotube surfaces","authors":"Camilla Di Mino, Thomas F. Headen, Nadir S. Basma, David J. Buckley, Patrick L. Cullen, Martin C. Wilding, Milo S. P. Shaffer, Neal T. Skipper, Adam J. Clancy, Christopher A. Howard","doi":"10.1038/s41565-025-01865-9","DOIUrl":"https://doi.org/10.1038/s41565-025-01865-9","url":null,"abstract":"The ordering of ions and solvent molecules around nanostructures is of profound fundamental importance, from understanding biological processes to the manipulation of nanomaterials to optimizing electrochemical devices. Classical models commonly used to describe these systems treat the solvent simplistically, an approach that endures, in part, due to the extreme difficulty of attaining experimental measurements that challenge this approximation. Here we perform total neutron scattering experiments on model systems—concentrated amide solutions of negatively charged carbon nanotubes and sodium counterions—and measure remarkably complex intermediate-range molecular solvent ordering. The charged surface orders the solvents up to ∼40 Å, even beyond its dense concentric solvation shells. Notably, the molecular orientation of solvent in direct contact with the nanotube surface itself is distinct, lying near-parallel and not interacting with desolvated sodium counterions. In contrast, beyond this layer the ordering of solvent is perpendicular to the surface. Our results underscore the critical importance of multibody interactions in solvated nanoscale systems and charged surfaces, highlighting competing ion/surface solvation effects.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"47 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracellular dehydrogenation catalysis leads to reductive stress and immunosuppression 细胞内脱氢催化导致还原性应激和免疫抑制

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-02-20 DOI: 10.1038/s41565-025-01870-y

Jie Jiang, Huizhen Zheng, Zhenzhen Wang, Xinlian Wang, Qianqian Xie, Xi Liu, Qing Yang, Xiaoming Cai, Xingfa Gao, Ruibin Li, Chunying Chen

{"title":"Intracellular dehydrogenation catalysis leads to reductive stress and immunosuppression","authors":"Jie Jiang, Huizhen Zheng, Zhenzhen Wang, Xinlian Wang, Qianqian Xie, Xi Liu, Qing Yang, Xiaoming Cai, Xingfa Gao, Ruibin Li, Chunying Chen","doi":"10.1038/s41565-025-01870-y","DOIUrl":"https://doi.org/10.1038/s41565-025-01870-y","url":null,"abstract":"Imbalanced redox homeostasis, involving either oxidative stress or reductive stress, can profoundly impact cellular functions, contributing to various diseases. While the implications of oxidative stress in the adverse effects of nanoparticles have been extensively studied, our comprehension of reductive stress within the context of nano-redox system interactions remains limited. Here we illuminate a domino effect initiated by the dehydrogenase-like activity of transition metal borides. Specifically, seven transition metal borides were identified to emulate the enzymatic activity of natural dehydrogenases, resulting in heightened levels of reductive constituents within critical biological redox pairs in cells. Mass cytometry analysis provides compelling evidence that reductive stress initiates an immunosuppressive environment within lung tissues, promoting the metastasis of breast cancer cells to the lungs. In summary, our study unveils the chemical basis of nano-induced reductive stress and establishes a mechanistic axis that interlinks dehydrogenase-like activity, reductive stress, immunosuppression and tumour metastasis.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"25 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Momentum tunnelling across quantum barriers 跨越量子势垒的动量隧穿

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2025-02-20 DOI: 10.1038/s41565-025-01868-6

Zhiping Xu

引用次数: 0

Grover’s algorithm in a four-qubit silicon processor above the fault-tolerant threshold 格罗弗算法在四量子位硅处理器中的容错阈值以上

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-02-20 DOI: 10.1038/s41565-024-01853-5

I. Thorvaldson, D. Poulos, C. M. Moehle, S. H. Misha, H. Edlbauer, J. Reiner, H. Geng, B. Voisin, M. T. Jones, M. B. Donnelly, L. F. Peña, C. D. Hill, C. R. Myers, J. G. Keizer, Y. Chung, S. K. Gorman, L. Kranz, M. Y. Simmons

{"title":"Grover’s algorithm in a four-qubit silicon processor above the fault-tolerant threshold","authors":"I. Thorvaldson, D. Poulos, C. M. Moehle, S. H. Misha, H. Edlbauer, J. Reiner, H. Geng, B. Voisin, M. T. Jones, M. B. Donnelly, L. F. Peña, C. D. Hill, C. R. Myers, J. G. Keizer, Y. Chung, S. K. Gorman, L. Kranz, M. Y. Simmons","doi":"10.1038/s41565-024-01853-5","DOIUrl":"https://doi.org/10.1038/s41565-024-01853-5","url":null,"abstract":"Spin qubits in silicon are strong contenders for the realization of a practical quantum computer. Single- and two-qubit gates have shown fidelities above the fault-tolerant threshold, and entanglement of three qubits has been achieved. Furthermore, high-fidelity operation of two-qubit algorithms is possible. Here we implement a four-qubit silicon processor with all control fidelities above the fault-tolerant threshold. We demonstrate a three-qubit Grover’s search algorithm with a ~95% probability of finding the marked state. To this end, we fabricate the processor from three phosphorus atoms precision-patterned into isotopically pure silicon. We define three phosphorus nuclear spin qubits and one electron spin qubit. The long coherence times of the qubits enable single-qubit fidelities above 99.9% for all qubits. Moreover, the efficient single-pulse multi-qubit operation enabled by the electron–nuclear hyperfine interaction facilitates controlled-Z gates with above 99% fidelity between all pairs of nuclear spins when using the electron as an ancilla. These control fidelities, combined with high-fidelity non-demolition readout of all nuclear spins, allows the creation of a three-qubit Greenberger–Horne–Zeilinger state with 96.2% fidelity. Looking ahead, coupling neighbouring nuclear spin registers, as the one shown here, via electron–electron exchange may enable larger, yet fault-tolerant, quantum processors.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"11 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular-scale CO spillover on a dual-site electrocatalyst enhances methanol production from CO2 reduction 双点电催化剂上的分子级CO溢出提高了CO2还原甲醇的产量

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-02-18 DOI: 10.1038/s41565-025-01866-8

Jing Li, Quansong Zhu, Alvin Chang, Seonjeong Cheon, Yuanzuo Gao, Bo Shang, Huan Li, Conor L. Rooney, Longtao Ren, Zhan Jiang, Yongye Liang, Zhenxing Feng, Shize Yang, L. Robert Baker, Hailiang Wang

{"title":"Molecular-scale CO spillover on a dual-site electrocatalyst enhances methanol production from CO2 reduction","authors":"Jing Li, Quansong Zhu, Alvin Chang, Seonjeong Cheon, Yuanzuo Gao, Bo Shang, Huan Li, Conor L. Rooney, Longtao Ren, Zhan Jiang, Yongye Liang, Zhenxing Feng, Shize Yang, L. Robert Baker, Hailiang Wang","doi":"10.1038/s41565-025-01866-8","DOIUrl":"https://doi.org/10.1038/s41565-025-01866-8","url":null,"abstract":"Cobalt phthalocyanine (CoPc) is recognized for catalysing electrochemical CO2 reduction into methanol at high Faradaic efficiency but is subject to deactivation. Cobalt tetraaminophthalocyanine (CoPc-NH2) shows improved stability, but its methanol Faradaic efficiency is below 30%. This study addresses these limitations in selectivity, reactivity and stability by rationally designing a dual-site cascade catalyst. Here we quantify the local concentration of CO, a key intermediate of the reaction, near a working CoPc-NH2 catalyst and show that co-loading nickel tetramethoxyphthalocyanine (NiPc-OCH3) with CoPc-NH2 on multiwalled carbon nanotubes increases the generation and local concentration of CO. This dual-site cascade catalyst exhibits substantially higher performance than the original single-site CoPc-NH2/carbon nanotube catalyst, reaching a partial current density of 150 mA cm−2 and a Faradaic efficiency of 50% for methanol production. Kinetic analysis and in situ sum-frequency generation vibrational spectroscopy attribute this notable performance improvement to molecular-scale CO spillover from NiPc-OCH3 sites to methanol-active CoPc-NH2 sites.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"8 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Welcome to Technology Features 欢迎来到技术特色

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2025-02-18 DOI: 10.1038/s41565-025-01883-7

引用次数: 0

Tandem-controlled lysosomal assembly of nanofibres induces pyroptosis for cancer immunotherapy 串联控制溶酶体组装纳米纤维诱导焦亡用于癌症免疫治疗

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-02-18 DOI: 10.1038/s41565-025-01857-9

Junya Zhang, Yuxuan Hu, Xidan Wen, Zeyue Yang, Ziyi Wang, Zhiyuan Feng, He Bai, Qi Xue, Yinxing Miao, Tian Tian, Peng Zheng, Jingjing Zhang, Jie Li, Ling Qiu, Jing-Juan Xu, Deju Ye

{"title":"Tandem-controlled lysosomal assembly of nanofibres induces pyroptosis for cancer immunotherapy","authors":"Junya Zhang, Yuxuan Hu, Xidan Wen, Zeyue Yang, Ziyi Wang, Zhiyuan Feng, He Bai, Qi Xue, Yinxing Miao, Tian Tian, Peng Zheng, Jingjing Zhang, Jie Li, Ling Qiu, Jing-Juan Xu, Deju Ye","doi":"10.1038/s41565-025-01857-9","DOIUrl":"https://doi.org/10.1038/s41565-025-01857-9","url":null,"abstract":"Pyroptosis has emerged as a promising approach for cancer immunotherapy. However, current pyroptosis inducers lack specificity for cancer cells and have a weak antitumour immune response. Here we report a tumour-specific nanoparticle (NP-NH-D5) that activates pyroptosis by disrupting lysosomes for cancer immunotherapy. NP-NH-D5 undergoes negative-to-positive charge reversal and nanoparticle-to-nanofibre transformation within tumour cell lysosomes through tandem response to extracellular matrix metallopeptidase-2 and intracellular reducing agents. The as-formed non-peptide nanofibres efficiently break the lysosomes and trigger gasdermin-D-mediated pyroptosis, leading to strong immunogenic cell death and alleviation of the immunosuppressive tumour microenvironment. In vivo, NP-NH-D5 inhibits orthotopic 4T1 breast tumours, prevents metastasis and recurrence, and prolongs survival without systemic side effects. Furthermore, it greatly enhances the effectiveness of PD-L1 antibody immunotherapy in the 4T1 late-stage lung metastasis and aggressive orthotopic Pan02 pancreatic tumour models. Our research may open pathways for developing stimuli-responsive pyroptosis inducers for precise cancer immunotherapy.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"12 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0