Nature nanotechnology最新文献

{"title":"In vivo transformations of positively charged nanoparticles alter the formation and function of RuBisCO photosynthetic protein corona","authors":"Christopher Castillo, Su-Ji Jeon, Khoi Nguyen L. Hoang, Claire Alford, Erica Svendahl, Chaoyi Deng, Yi Wang, Yinhan Wang, Xingfei Wei, Rigoberto Hernandez, Jason C. White, Korin E. Wheeler, Catherine J. Murphy, Juan Pablo Giraldo","doi":"10.1038/s41565-025-01944-x","DOIUrl":"10.1038/s41565-025-01944-x","url":null,"abstract":"The impact of nanomaterial transformations on photosynthetic proteins remains largely unknown. We report positively charged iron oxide (Fe3O4) nanoparticles experience transformations in Arabidopsis thaliana plants in vivo that alter the formation and function of RuBisCO protein corona, a key carbon fixation enzyme. In vitro, negatively charged Fe3O4 nanoparticles impact the RuBisCO function but not their positively charged counterparts. Computational and in vitro proteomic analyses revealed that positively charged Fe3O4 nanoparticles preferentially bind to a RuBisCO small subunit that lacks active carboxylation sites. However, both positively and negatively charged nanoparticles decrease RuBisCO carboxylation activity after experiencing transformations in vivo by 3.0 and 1.7 times relative to the controls, respectively. The pH- and lipid-coating-dependent transformations that occur during nanoparticle transport across plant membranes enhance RuBisCO binding to positively charged nanoparticles affecting its distribution in chloroplasts. Elucidating the rules of how nanoparticle properties and transformations affect photosynthetic coronas is crucial for sustainable nano-enabled agriculture. Experimental and computational analyses indicated that positively charged nanoparticles experience pH- and lipid-coating-dependent transformations in plants that modify their impact on RuBisCO photosynthetic protein corona formation and function.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 8","pages":"1152-1162"},"PeriodicalIF":34.9,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic nanodomains dictate macroscopic properties in lead halide perovskites","authors":"Milos Dubajic, James R. Neilson, Johan Klarbring, Xia Liang, Stephanie A. Bird, Kirrily C. Rule, Josie E. Auckett, Thomas A. Selby, Ganbaatar Tumen-Ulzii, Yang Lu, Young-Kwang Jung, Cullen Chosy, Zimu Wei, Yorrick Boeije, Martin v. Zimmermann, Andreas Pusch, Leilei Gu, Xuguang Jia, Qiyuan Wu, Julia C. Trowbridge, Eve M. Mozur, Arianna Minelli, Nikolaj Roth, Kieran W. P. Orr, Arman Mahboubi Soufiani, Simon Kahmann, Irina Kabakova, Jianning Ding, Tom Wu, Gavin J. Conibeer, Stephen P. Bremner, Michael P. Nielsen, Aron Walsh, Samuel D. Stranks","doi":"10.1038/s41565-025-01917-0","DOIUrl":"10.1038/s41565-025-01917-0","url":null,"abstract":"Lead halide perovskites have emerged as promising materials for solar energy conversion and X-ray detection owing to their remarkable optoelectronic properties. However, the microscopic origins of their superior performance remain unclear. Here we show that low-symmetry dynamic nanodomains present in the high-symmetry average cubic phases, whose characteristics are dictated by the A-site cation, govern the macroscopic behaviour. We combine X-ray diffuse scattering, inelastic neutron spectroscopy, hyperspectral photoluminescence microscopy and machine-learning-assisted molecular dynamics simulations to directly correlate local nanoscale dynamics with macroscopic optoelectronic response. Our approach reveals that methylammonium-based perovskites form densely packed, anisotropic dynamic nanodomains with out-of-phase octahedral tilting, whereas formamidinium-based systems develop sparse, isotropic, spherical nanodomains with in-phase tilting, even when crystallography reveals cubic symmetry on average. We demonstrate that these sparsely distributed isotropic nanodomains present in formamidinium-based systems reduce electronic dynamic disorder, resulting in a beneficial optoelectronic response, thereby enhancing the performance of formamidinium-based lead halide perovskite devices. By elucidating the influence of the A-site cation on local dynamic nanodomains, and consequently, on the macroscopic properties, we propose leveraging this relationship to engineer the optoelectronic response of these materials, propelling further advancements in perovskite-based photovoltaics, optoelectronics and X-ray imaging. Dynamic nanodomains in lead halide perovskites, dictated by A-site cations, crucially affect the optoelectronic properties by modulating electronic disorder and consequently enabling better solar cells and optoelectronic devices.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 6","pages":"755-763"},"PeriodicalIF":34.9,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41565-025-01917-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144193129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application-driven design of non-aqueous electrolyte solutions through quantification of interfacial reactions in lithium metal batteries","authors":"Hansen Wang, Xiaolin Yan, Rupeng Zhang, Juanjuan Sun, Fuxiang Feng, Haoran Li, Jinding Liang, Yuchun Wang, Guangzhou Ye, Xiaonan Luo, Shengyuan Huang, Pan Wan, Samantha T. Hung, Fangjun Ye, Fangyun Chen, Erxiao Wu, Jinfei Zhou, Ulderico Ulissi, Xiaoming Ge, Chengyong Liu, Bo Xu, Na Liu, Chuying Ouyang","doi":"10.1038/s41565-025-01935-y","DOIUrl":"10.1038/s41565-025-01935-y","url":null,"abstract":"Unwanted side reactions occurring at electrode|electrolyte interfaces significantly impact the cycling life of lithium metal batteries. However, a comprehensive view that rationalizes these interfacial reactions and assesses them both qualitatively and quantitatively is not yet established. Here, by combining multiple analytical techniques, we systematically investigate the interfacial reactions in lithium metal batteries containing ether-based non-aqueous electrolyte solutions. We quantitatively monitor various nanoscale-driven processes such as the reduction and oxidation pathways of lithium salt and organic solvents, the formation of various solid-electrolyte interphase species, the gas generation within the cell and the cross-talk processes between the electrodes. We demonstrate that the consumption of lithium ions owing to the continuous decomposition of the lithium bis(fluorosulfonyl)imide salt, which dominates the interfacial reactions, results in ion depletion during the cell discharge and battery failure. On the basis of these findings, we propose an electrolyte formulation in which lithium bis(fluorosulfonyl)imide content is maximized without compromising dynamic viscosity and bulk ionic conductivity, aiming for long-cycling battery performance. Following this strategy, we assemble and test Li (20 μm thickness)||LiNi0.8Mn0.1Co0.1O2 (17.1 mg cm−2 of active material) single-layer stack pouch cells in lean electrolyte conditions (that is, 2.1 g Ah−1), which can effectively sustain 483 charge (0.2 C or 28 mA)/discharge (1 C or 140 mA) cycles at 25 °C demonstrating a discharge capacity retention of about 77%. Tailored non-aqueous electrolyte solutions are formulated using data obtained from extensive analytical measurements and analyses. These optimized electrolytes improve the cycling performance of single-layer stack lithium metal pouch cells, particularly in lean electrolyte conditions.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 8","pages":"1034-1042"},"PeriodicalIF":34.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41565-025-01935-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twisted light with a designed polar topology","authors":"Qian Li, Jingbo Sun","doi":"10.1038/s41565-025-01927-y","DOIUrl":"10.1038/s41565-025-01927-y","url":null,"abstract":"Ferroelectric membranes of BaTiO3 can form centre-convergent polar topology domes that couple with light to generate circularly polarized beams.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 7","pages":"859-860"},"PeriodicalIF":34.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supramolecular polymerization through rotation of light-driven molecular motors","authors":"Philippe Schiel, Mounir Maaloum, Emilie Moulin, Irina Nyrkova, Alexander Semenov, Damien Dattler, Lou-Ann Accou, Anastasia Christoulaki, Eric Buhler, Rémi Plamont, Jean-Marie Lehn, Nicolas Giuseppone","doi":"10.1038/s41565-025-01933-0","DOIUrl":"10.1038/s41565-025-01933-0","url":null,"abstract":"Molecular motors can act on their environment through their unique ability to generate non-reciprocal autonomous motions at the nanoscale. Although their operating principles are now understood, artificial molecular motors have yet to demonstrate their general capacity to confer novel properties on (supra)molecular systems and materials. Here we show that amphiphilic light-driven molecular motors can adsorb onto an air‒water interface and form Langmuir monolayers upon compression. By irradiation with ultraviolet light, the surface pressure isotherms of these films reveal a drastic shift toward a smaller molecular area as a consequence of motor activation. We explain this counterintuitive phenomenon by the rotation-induced supramolecular polymerization of amphiphilic motors through a non-thermal annealing process to escape a kinetically trapped amorphous state. The effect is limited by the maximum torque the molecular motor can deliver (~10 pN nm) and leads to the formation of highly organized patterns. This serendipitous discovery highlights the opportunities offered by molecular motors to control supramolecular polymerization for the design of innovative materials. An amphiphilic light-driven rotary motor is shown to form Langmuir monolayers at the air–water interface. Upon ultraviolet irradiation, the continuous rotation of the motor triggers its supramolecular polymerization and subsequent nanopatterning of the interfacial layer.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 8","pages":"1052-1061"},"PeriodicalIF":34.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular motors in action at interfaces","authors":"Qi Zhang, Da-Hui Qu","doi":"10.1038/s41565-025-01936-x","DOIUrl":"10.1038/s41565-025-01936-x","url":null,"abstract":"Integrating molecular motors into amphiphilic surfactants creates light-activated, fast-spinning molecules that drive conformational changes, offering a non-thermal pathway to supramolecular polymerization.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 8","pages":"983-984"},"PeriodicalIF":34.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoinducer-mediated mitochondria-selective degradation enhances T cell immunotherapy against multiple cancers","authors":"Xueting Pan, Zhihang Wang, Mixiao Tan, Ziying Fu, Guangjun Nie, Hai Wang","doi":"10.1038/s41565-025-01909-0","DOIUrl":"10.1038/s41565-025-01909-0","url":null,"abstract":"Cancer immunotherapy utilizing cytotoxic T lymphocytes has demonstrated significant promise in clinical applications, but cancer immunosuppressive mechanisms hamper further progress in T cell immunotherapy. Here we show a correlation between cancer cell mitochondrial content and their resistance to immunotherapy. Observing that cancer cells with higher mitochondrial content show increased resistance to CD8+ T cells, we developed mitochondrial nanoinducers designed to selectively target and degrade mitochondria within autophagosomes. The direct degradation of mitochondria not only enhances the recognition and activation of CD8+ T cells but also increases the susceptibility of cancer cells to CD8+ T cell-mediated cytotoxicity. We demonstrated the feasibility and efficacy of this strategy in multiple in vitro and in vivo tumour therapeutic models. This nanoinducer, designed to manipulate cellular mitochondrial degradation, holds promise as a versatile tool for enhancing adoptive T cell therapy, CAR-T cell therapy and tumour-vaccine-based immunotherapy. Mitochondrial nanoinducers that degrade mitochondria via autophagy enhance T cell activation and tumour cell susceptibility, improving immunotherapy.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 7","pages":"947-958"},"PeriodicalIF":34.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144104503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Degrading cancer cell mitochondria to improve T cell-mediated killing","authors":"Luca Simula, Emmanuel Donnadieu","doi":"10.1038/s41565-025-01928-x","DOIUrl":"10.1038/s41565-025-01928-x","url":null,"abstract":"A nano-enabled strategy that reduces the mitochondrial content of cancer cells boosts immunotherapy outcomes in several animal cancer models.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 7","pages":"863-864"},"PeriodicalIF":34.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144104500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A collagenase nanogel backpack improves CAR-T cell therapy outcomes in pancreatic cancer","authors":"Zhipeng Zhao, Qian Li, Chenghao Qu, Zeyu Jiang, Guoqing Jia, Gongde Lan, Yuxia Luan","doi":"10.1038/s41565-025-01924-1","DOIUrl":"10.1038/s41565-025-01924-1","url":null,"abstract":"Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of haematological malignancies. Challenges in overcoming physical barriers however greatly limit CAR-T cell efficacy in solid tumours. Here we show that an approach based on collagenase nanogel generally improves the outcome of T cell-based therapies, and specifically of CAR-T cell therapy. The nanogels are created by cross-linking collagenase and subsequently modifying them with a CXCR4 antagonist peptide. These nanogels can bind CAR-T cells via receptor–ligand interaction, resulting in cellular backpack delivery systems. The nanogel backpacks modulate tumoural infiltration and localization of CAR-T cells by surmounting physical barriers and disrupting chemokine-mediated CAR-T cell imprisonment, thereby addressing their navigation deficiency within solid tumours. Our approach offers a promising strategy for pancreatic cancer therapy and holds potential for advancing CAR-T cell therapy towards clinical applications. A collagenase nanogel backpack enhances CAR-T cell therapy in pancreatic cancer by improving cell infiltration and overcoming physical barriers, enabling potent tumour regression and prolonged survival.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 8","pages":"1131-1141"},"PeriodicalIF":34.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electric bias-induced reversible configuration of single and heteronuclear dual-atom catalysts on 1Tʹ-MoS2","authors":"Jianhua Wu, Zhongxin Chen, Ke Yang, Xin Zhou, Huizhi Li, Zhiyong Wang, Mengyao Su, Rongrong Zhang, Tie Wang, Qikun Hu, Ning Yan, Cuibo Liu, Bin Zhang, Ming Yang, Shibo Xi, Kian Ping Loh","doi":"10.1038/s41565-025-01934-z","DOIUrl":"10.1038/s41565-025-01934-z","url":null,"abstract":"The development of substrates capable of anchoring single-atom catalysts (SACs) while enabling their dynamic reconfiguration into heteronuclear dual-atom catalysts (DACs) holds considerable promise for electrochemical synthesis, yet remains underexplored. Here we show that electrochemical desulfurization of MoS2 generates vacancy-rich 1T′ domains, which support high loadings of Cu (7.9 wt%) and Pt (6.7 wt%) SACs that are well-positioned for dynamic sintering to form DACs. Operando X-ray absorption spectroscopy and density functional theory calculations reveal a voltage-driven, reversible transformation between individual Pt/Cu SACs and Cu–Pt DAC configurations during hydrogen evolution reaction potentials. The electric-field-induced Cu–Pt DACs exhibit superior performance in the selective hydrogenation of alkynes compared with their monometallic SAC counterparts. This work underscores vacancy-enriched 1T′-MoS2 as a versatile platform for high-density SAC deposition, enabling on-demand structural reconfiguration and paving the way for tailored catalyst design in electrosynthesis. A dynamic Cu–Pt dual-atom catalyst supported on 1Tʹ-MoS2 can be electrically switched between single- and dual-atom configurations, enabling on-demand control for alkyne semi-hydrogenation.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 8","pages":"1043-1051"},"PeriodicalIF":34.9,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}