Nature nanotechnology最新文献_第8页

Intracellular ‘gobstoppers’ enable programmed cargo release 细胞内的“gobstoppers”实现了程序化的货物释放。

IF 37.5 1区材料科学

Nature nanotechnology Pub Date : 2026-07-31 DOI: 10.1038/s41565-026-02231-z

Christopher D. Snow

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Coherent room-temperature dipole synchronization in plasmonic nanocavities 等离子体纳米腔中相干室温偶极子同步

IF 37.5 1区材料科学

Nature nanotechnology Pub Date : 2026-07-30 DOI: 10.1038/s41565-026-02242-w

Rakesh Arul, Piper Fowler-Wright, Lille Børresen, Brendon W. Lovett, Jonathan Keeling, Jeremy J. Baumberg

{"title":"Coherent room-temperature dipole synchronization in plasmonic nanocavities","authors":"Rakesh Arul, Piper Fowler-Wright, Lille Børresen, Brendon W. Lovett, Jonathan Keeling, Jeremy J. Baumberg","doi":"10.1038/s41565-026-02242-w","DOIUrl":"10.1038/s41565-026-02242-w","url":null,"abstract":"Plasmonic nanocavities enable the synchronization of spatially distant emissive dipoles through strong near-field coupling in subnanometre gaps. Yet, it remains unclear how collective phase order can emerge in nanoscale optical systems where dissipation, disorder and ultrafast radiative loss normally suppress long-lived coherence. Here we report the formation of a room-temperature synchronized dipole state in locally ordered plasmonic nanogap two-dimensional arrays under non-resonant continuous-wave pumping. The system consists of methylene blue emitters confined in cucurbit[7]uril-defined subnanometre gaps between close-packed gold nanoparticles. Unlike lasers, photonic Bose–Einstein condensates or exciton–polariton condensates, this system exhibits spatial coherence across the dipoles, while rapid radiative emission suppresses temporal photon coherence. Increased coherence is observed with increasing pumping, marked by the spatial spread of g(1) coherence, but without spectral narrowing or directional emission. This driven-dissipative system exhibits fast temporal coherence formation within 10 fs and complex spatial correlations. Combining ultralow mode volumes and high Purcell enhancement, it offers a scalable platform for studying dipole synchronization at room temperature for photonic and quantum technologies. Dipoles in self-assembled gold nanogaps synchronize at room temperature, generating spatially coherent light without laser-like narrowing.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"21 9","pages":"1230-1237"},"PeriodicalIF":37.5,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41565-026-02242-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148612763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Strain-isolated microneedles for ambulatory hormonal and metabolic monitoring 用于动态激素和代谢监测的菌株分离微针

IF 37.5 1区材料科学

Nature nanotechnology Pub Date : 2026-07-29 DOI: 10.1038/s41565-026-02247-5

Gwangmook Kim, Seokjoo Cho, Hyunah Ahn, Canran Wang, Hong Han, Xiaotian Ma, Moon-Ju Kim, Jin Qu, Jihong Min, Wei Gao

{"title":"Strain-isolated microneedles for ambulatory hormonal and metabolic monitoring","authors":"Gwangmook Kim, Seokjoo Cho, Hyunah Ahn, Canran Wang, Hong Han, Xiaotian Ma, Moon-Ju Kim, Jin Qu, Jihong Min, Wei Gao","doi":"10.1038/s41565-026-02247-5","DOIUrl":"10.1038/s41565-026-02247-5","url":null,"abstract":"Hormones and metabolites jointly regulate physiology yet their dynamic interplay remains difficult to resolve due to the lack of technologies for continuous, multiplexed monitoring. Microneedle biosensors that access dermal interstitial fluid offer a minimally invasive approach to molecular profiling, but deployment is limited by trade-offs between fabrication scalability and precision, and by mechanical instability under skin deformation. Here we present a strain-isolated microneedle platform fabricated by combining two-photon polymerization with ultrasound-assisted moulding, enabling scalable replication of submicrometre-sharp microneedles (∼430-nm apex width) bearing hierarchical, high-surface-area microstructures. Nanostructured gold and platinum electrodes enable high-fidelity sensing at the single-needle level, providing a 4.7-fold higher peak current and a 9-fold larger electrochemical surface area, respectively. Mechanical decoupling of the sensing interface from tissue deformation preserves stable molecular access during motion. When integrated with battery-free wireless electronics and multiplexed aptameric and enzymatic sensors, the system enables continuous in vivo monitoring of serotonin and glucose for 12 h. In freely moving rats, the platform captures biomolecular dynamics associated with stress, feeding and circadian rhythms. This work establishes a mechanically robust, scalable microneedle biointerface for ambulatory molecular monitoring and context-aware assessment of physiological state. A wearable microneedle platform integrating ultrasharp, skin-penetrating tips, mechanical decoupling and electrochemical biosensing enables continuous, minimally invasive molecular profiling in freely moving animals, thereby advancing real-time, personalized health monitoring.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"21 10","pages":"1448-1458"},"PeriodicalIF":37.5,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148612595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Upconverting nanoparticles enable bioimaging with sub-ångström precision 上转换纳米颗粒使生物成像与亚-ångström精度。

IF 37.5 1区材料科学

Nature nanotechnology Pub Date : 2026-07-28 DOI: 10.1038/s41565-026-02253-7

引用次数: 0

Hidden spin-valley locking stabilizes nanosecond spin polarization in 2D perovskites 隐藏自旋谷锁定稳定二维钙钛矿的纳秒自旋极化。

IF 37.5 1区材料科学

Nature nanotechnology Pub Date : 2026-07-27 DOI: 10.1038/s41565-026-02238-6

Rayan Chakraborty, Yifan Dong, Jacob L. Shelton, Kelsey Garden, Leo Romanetz, Matthew P. Hautzinger, Matthew C. Beard, Volker Blum, David B. Mitzi

{"title":"Hidden spin-valley locking stabilizes nanosecond spin polarization in 2D perovskites","authors":"Rayan Chakraborty, Yifan Dong, Jacob L. Shelton, Kelsey Garden, Leo Romanetz, Matthew P. Hautzinger, Matthew C. Beard, Volker Blum, David B. Mitzi","doi":"10.1038/s41565-026-02238-6","DOIUrl":"10.1038/s41565-026-02238-6","url":null,"abstract":"Room-temperature spin control in semiconductors is fundamental to spin-optoelectronics. Although inversion symmetry breaking offers one path for spin control in semiconductors, strong spin dephasing at elevated temperatures remains a persistent limitation. Hidden spin polarization without global symmetry breaking provides another promising material design strategy, but robust spin stabilization from this effect has yet to be experimentally realized. Here we show spin stabilization at room temperature in two-dimensional hybrid organic–inorganic perovskites through hidden spin-valley locking. We use functional non-primary ammonium cations to induce symmetry-breaking distortions in the metal-halide layers, producing giant local spin splitting while preserving global inversion symmetry. Time-resolved circular dichroism measurements reveal optically generated spin-polarized carriers that persist for 686 ps in (AzOH)2PbI4 and 4.7 ns in the lead-free analogue (AzOH)2SnI4 at room temperature, without an external magnetic field. First-principles calculations suggest that these long lifetimes arise from hidden spin valleys, enhanced dielectric screening and reduced spin–orbit-induced scattering in the Sn-based compound. Our design paradigm unlocks inversion-symmetric semiconductors with ultralong spin lifetimes, broadening the materials options for light-driven spin control. Inversion-symmetric 2D hybrid perovskite semiconductors exhibit optically excited spin lifetimes of 0.7–4.7 ns at room temperature due to intrinsic local symmetry breaking and spin-valley formation.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"21 10","pages":"1398-1405"},"PeriodicalIF":37.5,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148605432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Spontaneous and indefinite blinking in upconverting nanoparticles for ångström-precision multicolour super-resolution imaging 自发和无限闪烁在上转换纳米粒子ångström-precision多色超分辨率成像。

IF 37.5 1区材料科学

Nature nanotechnology Pub Date : 2026-07-27 DOI: 10.1038/s41565-026-02233-x

Saptarshi Mandal, Harrison W. Toll, Kaibo Ma, Irmuun Tommy Altankhuyag, Lidao Li, Wanlin Zhang, João F. Shida, Chunte Sam Peng

{"title":"Spontaneous and indefinite blinking in upconverting nanoparticles for ångström-precision multicolour super-resolution imaging","authors":"Saptarshi Mandal, Harrison W. Toll, Kaibo Ma, Irmuun Tommy Altankhuyag, Lidao Li, Wanlin Zhang, João F. Shida, Chunte Sam Peng","doi":"10.1038/s41565-026-02233-x","DOIUrl":"10.1038/s41565-026-02233-x","url":null,"abstract":"Single-molecule localization microscopy enables high-resolution biological imaging, but its precision is limited by the rapid photobleaching of conventional fluorophores. Multicolour imaging is further constrained by the need for spectrally distinct dyes requiring separate excitations or sequential acquisition. Here we show that small (~10 nm) upconverting nanoparticles can be compositionally tuned to exhibit spontaneous, sustained blinking under single near-infrared excitation without optical or chemical modulation. By adjusting sensitizer (Yb3+)–emitter (Tm3+/Er3+) ratios, we identify a regime with intrinsic ON–OFF switching and low duty cycles (~0.9%) without photobleaching or statistical aging, enabling repeated localizations and sub-ångström precision (0.62 Å over 88,000 localizations) in upconversion-enabled stochastic optical reconstruction microscopy. By elucidating the underlying physical mechanism of this blinking, we engineered blue- and red-emitting probes for multicolour upconversion-enabled stochastic optical reconstruction microscopy. This technique enables the resolution of tightly packed UCNPs and the visualization of epidermal growth factor receptor dimers and multimers on cell membranes at single-protein resolution, all achieved with a simple optical setup without imaging buffers. Compositionally engineered, spontaneously blinking upconverting nanoparticles enable multicolour super-resolution imaging with a single excitation source and achieve localization precision down to 0.62 Å for single-molecule imaging on cell membranes.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"21 9","pages":"1297-1307"},"PeriodicalIF":37.5,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41565-026-02233-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148605483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated blue ZnSe/ZnS quantum dot lasers on a silicon nitride platform 氮化硅平台上集成蓝色ZnSe/ZnS量子点激光器。

IF 37.5 1区材料科学

Nature nanotechnology Pub Date : 2026-07-27 DOI: 10.1038/s41565-026-02237-7

Jinhua He (, ), Korneel Molkens, Dries Van Thourhout, Pieter Geiregat, Zeger Hens, Ivo Tanghe

{"title":"Integrated blue ZnSe/ZnS quantum dot lasers on a silicon nitride platform","authors":"Jinhua He \u0000 (, ), Korneel Molkens, Dries Van Thourhout, Pieter Geiregat, Zeger Hens, Ivo Tanghe","doi":"10.1038/s41565-026-02237-7","DOIUrl":"10.1038/s41565-026-02237-7","url":null,"abstract":"On-chip blue lasers are essential for data storage, quantum photonics, optical communications and lab-on-chip sensing. Existing GaN-based devices deliver high performance but demand lattice-matched substrates, involve complex architectures and suffer from high optical losses in the visible range. Here we extend the CMOS-compatible fabrication methodology used to incorporate emitting colloidal quantum dots (QDs) with silicon nitride (SiNx) platforms from proven red and green to blue lasers. Implementing QD design rules for optimal gain performance, we obtain blue-emitting ZnSe/ZnS QDs with gain metrics on par with established red and green QDs. After encapsulating QD films with an organic/inorganic bilayer, we demonstrate stable lasing under femtosecond and nanosecond pumping using different cavity designs. Such films, coated on low-loss SiNx two-dimensional photonic crystal cavities, yield out-of-plane lasing between 425 and 445 nm, with quasi-continuous-wave thresholds of 7.5 kW cm−2. In addition, in-plane, waveguide-coupled lasing is demonstrated by depositing ZnSe/ZnS QD films on top of a one-dimensional distributed feedback cavity. Our work underscores the potential of non-toxic, solution-processable ZnSe-based QDs for integrated blue photonics. A CMOS-compatible fabrication methodology is developed to incorporate blue-emitting colloidal quantum dots within a silicon nitride (SiNx) platform to create integrated blue lasers.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"21 9","pages":"1245-1251"},"PeriodicalIF":37.5,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148605493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic delocalization of stress in brittle battery positive electrode active materials by shape-memory polymer nanocoating 基于形状记忆聚合物纳米涂层的脆性电池正极活性材料应力动态离域研究。

IF 37.5 1区材料科学

Nature nanotechnology Pub Date : 2026-07-23 DOI: 10.1038/s41565-026-02224-y

Yutong Liu, Wenhua Zuo, Wei Wang, Cong Lin, Qingsong Weng, Yinggang Zhu, Kai Zhang, Ke Du, Haihui Ruan, Feng Pan, Xuejie Huang, Xiang Liu, Hailong Yu, Guohua Chen, Qiang Liu

{"title":"Dynamic delocalization of stress in brittle battery positive electrode active materials by shape-memory polymer nanocoating","authors":"Yutong Liu, Wenhua Zuo, Wei Wang, Cong Lin, Qingsong Weng, Yinggang Zhu, Kai Zhang, Ke Du, Haihui Ruan, Feng Pan, Xuejie Huang, Xiang Liu, Hailong Yu, Guohua Chen, Qiang Liu","doi":"10.1038/s41565-026-02224-y","DOIUrl":"10.1038/s41565-026-02224-y","url":null,"abstract":"Stress-induced fractures are recognized as a primary cause of degradation in a wide range of positive electrode active materials during battery operation. However, the state-of-the-art mechanistic understanding and strategy development often overlook the brittle nature of these materials, as well as the dynamic and localized characteristics of mechanical stress during the charge and discharge cycles of the cell. Here we present a shape-memory polymer nanocoating method using initiated chemical vapour deposition to dynamically delocalize concentrated stresses in various positive electrode active materials, including Ni-rich layered oxides with different Ni contents and LiFePO4. Fracture simulations and surface-to-bulk physicochemical characterizations collectively show that the balanced stiffness and deformability of the shape-memory polymer nanocoating on the positive electrode material effectively mitigate stress gradients and the consequent surface reconstruction, chemical heterogeneity and intergranular cracking during battery operation. In particular, when a polymeric nanocoated nickel-rich layered oxide positive electrode active material (90 at% of Ni) is tested in non-aqueous lithium metal coin cell configuration at 25 °C, the cells can be consistently charged and discharged over long cycles at moderate (for example, 1,000 cycles at 400 mA g−1) and high (for example, 500 cycles at 1 A g−1) specific currents. Nanocoating of brittle positive electrode active materials with an ionically conductive polymer enables efficient operation of non-aqueous lithium metal coin cells at specific currents up to 2 A g−1.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"21 8","pages":"1154-1163"},"PeriodicalIF":37.5,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unbreakable battery positive electrodes 牢不可破的电池正极。

IF 37.5 1区材料科学

Nature nanotechnology Pub Date : 2026-07-23 DOI: 10.1038/s41565-025-02088-8

Matteo Bianchini

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Immunostimulatory lipogel implant enhances cancer immunotherapy 免疫刺激脂凝胶植入物增强癌症免疫治疗。

IF 37.5 1区材料科学

Nature nanotechnology Pub Date : 2026-07-23 DOI: 10.1038/s41565-026-02194-1

Ying Zhang, Enlai Wang, Shiyang Li, Yufan Yao, Quanlin Shao, Yanfang Wang, Yingjiao He, Mingqi Liu, Xiang Jin, Zhen Gu, Ran Mo

{"title":"Immunostimulatory lipogel implant enhances cancer immunotherapy","authors":"Ying Zhang, Enlai Wang, Shiyang Li, Yufan Yao, Quanlin Shao, Yanfang Wang, Yingjiao He, Mingqi Liu, Xiang Jin, Zhen Gu, Ran Mo","doi":"10.1038/s41565-026-02194-1","DOIUrl":"10.1038/s41565-026-02194-1","url":null,"abstract":"Cancer stem-like cells contribute to innate tumour immunoresistance and an immunosuppressive tumour microenvironment, leading to poor responses to immune checkpoint inhibitors. Chemotherapeutic agents can elicit tumour immunogenicity by inducing immunogenic cell death to reinforce the therapeutic efficacies of immune checkpoint inhibitors, but suffer from inefficient immunogenic cell death activation in highly resistant cancer stem-like cells. Here we report an immunostimulatory lyotropic liquid-crystal-based lipogel for localized co-delivery of all-trans retinoic acid, a differentiation-inducing drug, and doxorubicin, an immunogenic-cell-death-inducing chemotherapeutic agent with distinct release kinetics. The lipogel is tailored to release the combinatorial drugs in a differential and sustained manner, which fulfils the requirement for enhanced drug synergism in promoting the immunogenic cell death of cancer stem-like cells. Local implantation of the immunostimulatory lipogel elicits an antitumour immune response that is further augmented by an immune checkpoint inhibitor to suppress tumour growth and metastasis, as well as to prevent post-surgical recurrence in murine models of high-stemness tumours. A lipogel tailored with a differential and sustained release of combinatorial drugs can elicit tumour immunogenicity to counteract stemness-associated immunosuppression and augment immune-checkpoint-inhibitor-based immunotherapy.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"21 8","pages":"1203-1214"},"PeriodicalIF":37.5,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0