Nature nanotechnology最新文献_第8页

DNA origami force probes illuminate T cell receptor forces at the immune synapse DNA 折纸力探针揭示了免疫突触中 T 细胞受体的作用力。

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-08-26 DOI: 10.1038/s41565-024-01768-1

Tram Thi Hong Le, Byoung Choul Kim

引用次数: 0

High-entropy non-covalent cyclic peptide glass 高熵非共价环肽玻璃。

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-08-26 DOI: 10.1038/s41565-024-01766-3

Chengqian Yuan, Wei Fan, Peng Zhou, Ruirui Xing, Shuai Cao, Xuehai Yan

{"title":"High-entropy non-covalent cyclic peptide glass","authors":"Chengqian Yuan, Wei Fan, Peng Zhou, Ruirui Xing, Shuai Cao, Xuehai Yan","doi":"10.1038/s41565-024-01766-3","DOIUrl":"10.1038/s41565-024-01766-3","url":null,"abstract":"Biomolecule-based non-covalent glasses are biocompatible and biodegradable, and offer a sustainable alternative to conventional glass. Cyclic peptides (CPs) can serve as promising glass formers owing to their structural rigidity and resistance to enzymatic degradation. However, their potent crystallization tendency hinders their potential in glass construction. Here we engineered a series of CP glasses with tunable glass transition behaviours by modulating the conformational complexity of CP clusters. By incorporating multicomponent CPs, the formation of high-entropy CP glass is facilitated, which—in turn—inhibits the crystallization of individual CPs. The high-entropy CP glass demonstrates enhanced mechanical properties and enzyme tolerance compared with individual CP glass and a unique biorecycling capability that is unattainable by traditional glasses. These findings provide a promising paradigm for the design and development of stable non-covalent glasses based on naturally derived biomolecules, and advance their application in pharmaceutical formulations and smart functional materials. Biodegradable glasses are a sustainable alternative to traditional glass. Here high-entropy cyclic peptide glasses are engineered, with enhanced crystallization resistance, mechanical properties and enzyme tolerance.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 12","pages":"1840-1848"},"PeriodicalIF":38.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acid-degradable lipid nanoparticles enhance the delivery of mRNA 酸性可降解脂质纳米颗粒可增强 mRNA 的传递

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-08-23 DOI: 10.1038/s41565-024-01765-4

Sheng Zhao, Kewa Gao, Hesong Han, Michael Stenzel, Boyan Yin, Hengyue Song, Atip Lawanprasert, Josefine Eilsø Nielsen, Rohit Sharma, Opeyemi H. Arogundade, Sopida Pimcharoen, Yu-Ju Chen, Abhik Paul, Jan Tuma, Michael G. Collins, Yofiel Wyle, Matileen Grace Cranick, Benjamin W. Burgstone, Barbara S. Perez, Annelise E. Barron, Andrew M. Smith, Hye Young Lee, Aijun Wang, Niren Murthy

{"title":"Acid-degradable lipid nanoparticles enhance the delivery of mRNA","authors":"Sheng Zhao, Kewa Gao, Hesong Han, Michael Stenzel, Boyan Yin, Hengyue Song, Atip Lawanprasert, Josefine Eilsø Nielsen, Rohit Sharma, Opeyemi H. Arogundade, Sopida Pimcharoen, Yu-Ju Chen, Abhik Paul, Jan Tuma, Michael G. Collins, Yofiel Wyle, Matileen Grace Cranick, Benjamin W. Burgstone, Barbara S. Perez, Annelise E. Barron, Andrew M. Smith, Hye Young Lee, Aijun Wang, Niren Murthy","doi":"10.1038/s41565-024-01765-4","DOIUrl":"10.1038/s41565-024-01765-4","url":null,"abstract":"Lipid nanoparticle (LNP)–mRNA complexes are transforming medicine. However, the medical applications of LNPs are limited by their low endosomal disruption rates, high toxicity and long tissue persistence times. LNPs that rapidly hydrolyse in endosomes (RD-LNPs) could solve the problems limiting LNP-based therapeutics and dramatically expand their applications but have been challenging to synthesize. Here we present an acid-degradable linker termed ‘azido-acetal’ that hydrolyses in endosomes within minutes and enables the production of RD-LNPs. Acid-degradable lipids composed of polyethylene glycol lipids, anionic lipids and cationic lipids were synthesized with the azido-acetal linker and used to generate RD-LNPs, which significantly improved the performance of LNP–mRNA complexes in vitro and in vivo. Collectively, RD-LNPs delivered mRNA more efficiently to the liver, lung, spleen and brains of mice and to haematopoietic stem and progenitor cells in vitro than conventional LNPs. These experiments demonstrate that engineering LNP hydrolysis rates in vivo has great potential for expanding the medical applications of LNPs. A new acid-degradable linker termed ‘azido-acetal’ has been developed that rapidly hydrolyses at pH 6.0 but is stable at pH 7.4. Lipid nanoparticles made with this linker delivered mRNA in vivo and in vitro better than traditional lipid nanoparticles.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 11","pages":"1702-1711"},"PeriodicalIF":38.1,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142042625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local control of polarization and geometric phase in thermal metasurfaces 热元表面中偏振和几何相位的局部控制

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-08-23 DOI: 10.1038/s41565-024-01763-6

J. Ryan Nolen, Adam C. Overvig, Michele Cotrufo, Andrea Alù

{"title":"Local control of polarization and geometric phase in thermal metasurfaces","authors":"J. Ryan Nolen, Adam C. Overvig, Michele Cotrufo, Andrea Alù","doi":"10.1038/s41565-024-01763-6","DOIUrl":"10.1038/s41565-024-01763-6","url":null,"abstract":"Thermal emission from a hot body is inherently challenging to control due to its incoherent nature. Recent advances have shown that patterned surfaces can transform thermal emission into partially coherent beams with tailored directionality and frequency selectivity. Here we experimentally demonstrate polarization-selective, unidirectional and narrowband thermal emission using single-layer metasurfaces. By implementing polarization gradients across the surface, we unveil a generalization of the photonic Rashba effect from circular polarizations to any pair of orthogonal polarizations and apply it to thermal emission. Leveraging pointwise specification of arbitrary elliptical polarization, we implement a thermal geometric phase and leverage it to prove previous theoretical predictions that asymmetric chiral emission is possible without violating reciprocity. This general platform can be extended to other frequency regimes in efforts to compactify metasurface optics technologies without the need for external coherent sources. A metasurface is used to generalize the Rashba effect from circular polarizations to any polarization state for thermal emission.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 11","pages":"1627-1634"},"PeriodicalIF":38.1,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142042626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A primordial DNA store and compute engine 原始 DNA 存储和计算引擎

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-08-22 DOI: 10.1038/s41565-024-01771-6

Kevin N. Lin, Kevin Volkel, Cyrus Cao, Paul W. Hook, Rachel E. Polak, Andrew S. Clark, Adriana San Miguel, Winston Timp, James M. Tuck, Orlin D. Velev, Albert J. Keung

{"title":"A primordial DNA store and compute engine","authors":"Kevin N. Lin, Kevin Volkel, Cyrus Cao, Paul W. Hook, Rachel E. Polak, Andrew S. Clark, Adriana San Miguel, Winston Timp, James M. Tuck, Orlin D. Velev, Albert J. Keung","doi":"10.1038/s41565-024-01771-6","DOIUrl":"10.1038/s41565-024-01771-6","url":null,"abstract":"Any modern information system is expected to feature a set of primordial features and functions: a substrate stably carrying data; the ability to repeatedly write, read, erase, reload and compute on specific data from that substrate; and the overall ability to execute such functions in a seamless and programmable manner. For nascent molecular information technologies, proof-of-principle realization of this set of primordial capabilities would advance the vision for their continued development. Here we present a DNA-based store and compute engine that captures these primordial capabilities. This system comprises multiple image files encoded into DNA and adsorbed onto ~50-μm-diameter, highly porous, hierarchically branched, colloidal substrate particles comprised of naturally abundant cellulose acetate. Their surface areas are over 200 cm2 mg−1 with binding capacities of over 1012 DNA oligos mg−1, 10 TB mg−1 or 104 TB cm−3. This ‘dendricolloid’ stably holds DNA files better than bare DNA with an extrapolated ability to be repeatedly lyophilized and rehydrated over 170 times compared with 60 times, respectively. Accelerated ageing studies project half-lives of ~6,000 and 2 million years at 4 °C and −18 °C, respectively. The data can also be erased and replaced, and non-destructive file access is achieved through transcribing from distinct synthetic promoters. The resultant RNA molecules can be directly read via nanopore sequencing and can also be enzymatically computed to solve simplified 3 × 3 chess and sudoku problems. Our study establishes a feasible route for utilizing the high information density and parallel computational advantages of nucleic acids. Here, the authors present a data storage and computation engine comprised of DNA adsorbed to soft dendricolloids, demonstrating end-to-end capabilities from archival storage to non-destructive file access for reading, erasing, rewriting and computing.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 11","pages":"1654-1664"},"PeriodicalIF":38.1,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142022216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bolometric detection of Josephson radiation 约瑟夫森辐射的测光探测

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-08-22 DOI: 10.1038/s41565-024-01770-7

Bayan Karimi, Gorm Ole Steffensen, Andrew P. Higginbotham, Charles M. Marcus, Alfredo Levy Yeyati, Jukka P. Pekola

{"title":"Bolometric detection of Josephson radiation","authors":"Bayan Karimi, Gorm Ole Steffensen, Andrew P. Higginbotham, Charles M. Marcus, Alfredo Levy Yeyati, Jukka P. Pekola","doi":"10.1038/s41565-024-01770-7","DOIUrl":"10.1038/s41565-024-01770-7","url":null,"abstract":"One of the most promising approaches towards large-scale quantum computation uses devices based on many Josephson junctions. Yet, even today, open questions regarding the single junction remain unsolved, such as the detailed understanding of the quantum phase transitions, the coupling of the Josephson junction to the environment or how to improve the coherence of a superconducting qubit. Here we design and build an engineered on-chip reservoir connected to a Josephson junction that acts as an efficient bolometer for detecting the Josephson radiation under non-equilibrium, that is, biased conditions. The bolometer converts the a.c. Josephson current at microwave frequencies up to about 100 GHz into a temperature rise measured by d.c. thermometry. A circuit model based on realistic parameter values captures both the current–voltage characteristics and the measured power quantitatively. The present experiment demonstrates an efficient, wide-band, thermal detection scheme of microwave photons and provides a sensitive detector of Josephson dynamics beyond the standard conductance measurements. An on-chip nano-bolometer integrated with a Josephson junction quantitatively measures the Josephson radiation up to about 100 GHz frequency. This wide-band, thermal detection scheme of microwave photons provides a sensitive detector of Josephson dynamics beyond the standard conductance measurements.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 11","pages":"1613-1618"},"PeriodicalIF":38.1,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41565-024-01770-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142022286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A photo-controlled charge regulator improves cancer theranostics 光控电荷调节器改进了癌症治疗技术

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-08-21 DOI: 10.1038/s41565-024-01745-8

Shan Lei, Peng Huang

引用次数: 0

Photobleaching-mediated charge-convertible cyclodextrin nanoparticles achieve deep tumour penetration for rectal cancer theranostics 光漂白介导的电荷可转换环糊精纳米粒子实现肿瘤深层穿透，用于直肠癌治疗技术

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-08-21 DOI: 10.1038/s41565-024-01757-4

Duy-Thuc Nguyen, Min-Jun Baek, Sang Min Lee, Dahan Kim, So-Yeol Yoo, Jae-Young Lee, Dae-Duk Kim

{"title":"Photobleaching-mediated charge-convertible cyclodextrin nanoparticles achieve deep tumour penetration for rectal cancer theranostics","authors":"Duy-Thuc Nguyen, Min-Jun Baek, Sang Min Lee, Dahan Kim, So-Yeol Yoo, Jae-Young Lee, Dae-Duk Kim","doi":"10.1038/s41565-024-01757-4","DOIUrl":"10.1038/s41565-024-01757-4","url":null,"abstract":"Although charge-converting nanoparticles (NPs) potentially penetrate tumours deeply, conventional charge conversion strategies possess limitations, including low selectivity and slow, inconsistent conversion rate within the tumour microenvironment. In this study, we synthesized a zwitterionic near-infrared cyclodextrin derivative of heptamethine cyanine and complexed it with pheophorbide-conjugated ferrocene to produce multifunctional theranostic nanotherapeutics. Our NPs demonstrated enhanced tumour-targeting ability, enabling the highly specific imaging of rectal tumours, with tumour-to-rectum signal ratios reaching up to 7.8. The zwitterionic surface charge of the NPs was rapidly converted to a cationic charge within the tumours on 880 nm near-infrared laser irradiation, promoting the tumoural penetration of NPs via transcytosis. After penetration, photodynamic/chemodynamic therapy was initiated using a 660 nm laser. Our NPs eradicated clinically relevant-sized heterotopic tumours (~250 mm3) and orthotopic rectal tumours, displaying their potential as theranostic nanoplatforms for targeting rectal cancer. The photobleaching property of heptamethine cyanine enables efficient charge conversion of nanoparticles. Here heptamethine-cyanine-based nanoparticles achieve specific tumour imaging, deep tumour penetration and high therapeutic efficacy in rectal cancer animal models.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 11","pages":"1723-1734"},"PeriodicalIF":38.1,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142013824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microstrain screening towards defect-less layered transition metal oxide cathodes 实现无缺陷层状过渡金属氧化物阴极的微应变筛选

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-08-20 DOI: 10.1038/s41565-024-01734-x

Wenhua Zuo, Jihyeon Gim, Tianyi Li, Dewen Hou, Yibo Gao, Shiyuan Zhou, Chen Zhao, Xin Jia, Zhenzhen Yang, Yuzi Liu, Wenqian Xu, Xianghui Xiao, Gui-Liang Xu, Khalil Amine

{"title":"Microstrain screening towards defect-less layered transition metal oxide cathodes","authors":"Wenhua Zuo, Jihyeon Gim, Tianyi Li, Dewen Hou, Yibo Gao, Shiyuan Zhou, Chen Zhao, Xin Jia, Zhenzhen Yang, Yuzi Liu, Wenqian Xu, Xianghui Xiao, Gui-Liang Xu, Khalil Amine","doi":"10.1038/s41565-024-01734-x","DOIUrl":"10.1038/s41565-024-01734-x","url":null,"abstract":"Microstrain and the associated surface-to-bulk propagation of structural defects are known to be major roadblocks to developing high-energy and long-life batteries. However, the origin and effects of microstrain during the synthesis of battery materials remain largely unknown. Here we perform microstrain screening during real-time and realistic synthesis of sodium layered oxide cathodes. Evidence gathered from multiscale in situ synchrotron X-ray diffraction and microscopy characterization collectively reveals that the spatial distribution of transition metals within individual precursor particles strongly governs the nanoscale phase transformation, local charge heterogeneity and accumulation of microstrain during synthesis. This unexpected dominance of transition metals results in a counterintuitive outward propagation of defect nucleation and growth. These insights direct a more rational synthesis route to reduce the microstrain and crystallographic defects within the bulk lattice, leading to significantly improved structural stability. The present work on microstrain screening represents a critical step towards synthesis-by-design of defect-less battery materials. In situ synchrotron X-ray tools are used to perform microstrain screening during solid-state synthesis of battery materials, leading to fewer structural defects and improved performance.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 11","pages":"1644-1653"},"PeriodicalIF":38.1,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142007498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aharonov–Bohm interference and statistical phase-jump evolution in fractional quantum Hall states in bilayer graphene 双层石墨烯中分数量子霍尔态的阿哈诺夫-玻姆干涉和统计相位跃迁演化

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-08-20 DOI: 10.1038/s41565-024-01751-w

Jehyun Kim, Himanshu Dev, Ravi Kumar, Alexey Ilin, André Haug, Vishal Bhardwaj, Changki Hong, Kenji Watanabe, Takashi Taniguchi, Ady Stern, Yuval Ronen

{"title":"Aharonov–Bohm interference and statistical phase-jump evolution in fractional quantum Hall states in bilayer graphene","authors":"Jehyun Kim, Himanshu Dev, Ravi Kumar, Alexey Ilin, André Haug, Vishal Bhardwaj, Changki Hong, Kenji Watanabe, Takashi Taniguchi, Ady Stern, Yuval Ronen","doi":"10.1038/s41565-024-01751-w","DOIUrl":"10.1038/s41565-024-01751-w","url":null,"abstract":"In the fractional quantum Hall effect, quasiparticles are collective excitations that have a fractional charge and show fractional statistics as they interchange positions. While the fractional charge affects semi-classical characteristics such as shot noise and charging energies, fractional statistics is most notable through quantum interference. Here we study fractional statistics in a bilayer graphene Fabry–Pérot interferometer. We tune the interferometer from the Coulomb-dominated regime to the Aharonov–Bohm regime, both for integer and fractional quantum Hall states. Focusing on the fractional quantum Hall state with a filling factor ν = 1/3, we follow the evolution of the Aharonov–Bohm interference of quasiparticles while varying the magnetic flux through an interference loop and the charge density within the loop independently. When their combined variation is such that the Landau filling remains 1/3, the charge density in the loop varies continuously. We then observe pristine Aharonov–Bohm oscillations with a period of three flux quanta, as expected for quasiparticles of one-third of the electron charge. Yet, when the combined variation leads to discrete events of quasiparticle addition or removal, phase jumps emerge and alter the phase evolution. Notably, across all cases with discrete and continuous charge variation, the average phase consistently increases by 2π with each addition of one electron to the loop, as expected for quasiparticles, obeying fractional statistics. Electrostatically tunable graphene-based electronic interferometers show non-trivial exchange statistics of quasiparticles, revealing their wave-like properties.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 11","pages":"1619-1626"},"PeriodicalIF":38.1,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142007627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0