Nature nanotechnology最新文献_第7页

Colloidal chemistry in tin perovskite 锡钙钛矿中的胶体化学

IF 34.9 1区材料科学

Nature nanotechnology Pub Date : 2025-06-17 DOI: 10.1038/s41565-025-01959-4

Antonio Abate

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Nanoscience-enabled pathways to next-generation perovskite photovoltaics 纳米科学实现下一代钙钛矿光伏发电的途径。

IF 34.9 1区材料科学

Nature nanotechnology Pub Date : 2025-06-17 DOI: 10.1038/s41565-025-01967-4

引用次数: 0

Encoding molecular transport into DNA condensates 将分子运输编码成DNA凝聚体

IF 34.9 1区材料科学

Nature nanotechnology Pub Date : 2025-06-16 DOI: 10.1038/s41565-025-01956-7

Ayala Lampel

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A nanovaccine targeting cancer stem cells and bulk cancer cells for postoperative cancer immunotherapy 一种靶向肿瘤干细胞和大块癌细胞的纳米疫苗用于癌症术后免疫治疗

IF 34.9 1区材料科学

Nature nanotechnology Pub Date : 2025-06-16 DOI: 10.1038/s41565-025-01952-x

Qing You, Gege Wu, Hui Li, Jingyi Liu, Fangfang Cao, Lingwen Ding, Fuming Liang, Bo Zhou, Lilusi Ma, Ling Zhu, Chen Wang, Yanlian Yang, Xiaoyuan Chen

{"title":"A nanovaccine targeting cancer stem cells and bulk cancer cells for postoperative cancer immunotherapy","authors":"Qing You, Gege Wu, Hui Li, Jingyi Liu, Fangfang Cao, Lingwen Ding, Fuming Liang, Bo Zhou, Lilusi Ma, Ling Zhu, Chen Wang, Yanlian Yang, Xiaoyuan Chen","doi":"10.1038/s41565-025-01952-x","DOIUrl":"10.1038/s41565-025-01952-x","url":null,"abstract":"Residual cancer stem-like cells (CSCs) can cause tumour recurrence within a narrow margin around the initial tumour resection lesion, increasing the risk of post-surgical relapse and incurability. Currently, there are no efficient strategies for tracking and eradicating CSCs. Here we propose a nanovaccine strategy, called NICER, based on a nanovesicle system integrating CSC-specific antigen display and epigenetic nano-regulator encapsulation with a dendritic-cell-targeting aptamer, to simultaneously eradicate CSCs and bulk tumour cells. Specifically, nanovesicles derived from aldehyde-dehydrogenase-overexpressing tumours could serve as integrated antigens carrying both CSC-specific antigen and tumour-associated antigen. Epigenetic nano-regulator targeting YTH N6-methyladenosine RNA binding protein 1 could restrict dendritic cell lysosomal protease activity to modulate the effective cross-presentation of integrated antigens via major histocompatibility complex class I for immune responses. Overall, NICER represents a broad-spectrum vaccine approach against both CSCs and bulk tumours that can significantly inhibit postoperative cancer recurrence and metastasis, prolonging survival rates. NICER is a broad-spectrum nanovaccine based on a nanovesicle system that can induce an effective immune response via epigenetic regulation to target both cancer stem-like cells and bulk tumour cells to prevent tumour recurrence.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 9","pages":"1298-1311"},"PeriodicalIF":34.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoneedles enable spatiotemporal lipidomics of living tissues 纳米针可以实现活组织的时空脂质组学

IF 34.9 1区材料科学

Nature nanotechnology Pub Date : 2025-06-16 DOI: 10.1038/s41565-025-01955-8

Chenlei Gu, Davide Alessandro Martella, Leor Ariel Rose, Nadia Rouatbi, Cong Wang, Alaa Zam, Valeria Caprettini, Magnus Jensen, Shiyue Liu, Cathleen Hagemann, Siham Memdouh, Andrea Serio, Vincenzo Abbate, Khuloud T. Al-Jamal, Maddy Parsons, Mads S. Bergholt, Paul M. Brennan, Assaf Zaritsky, Ciro Chiappini

{"title":"Nanoneedles enable spatiotemporal lipidomics of living tissues","authors":"Chenlei Gu, Davide Alessandro Martella, Leor Ariel Rose, Nadia Rouatbi, Cong Wang, Alaa Zam, Valeria Caprettini, Magnus Jensen, Shiyue Liu, Cathleen Hagemann, Siham Memdouh, Andrea Serio, Vincenzo Abbate, Khuloud T. Al-Jamal, Maddy Parsons, Mads S. Bergholt, Paul M. Brennan, Assaf Zaritsky, Ciro Chiappini","doi":"10.1038/s41565-025-01955-8","DOIUrl":"10.1038/s41565-025-01955-8","url":null,"abstract":"Spatial biology provides high-content diagnostic information by mapping the molecular composition of tissues. However, traditional spatial biology approaches typically require non-living samples, limiting temporal analysis. Here, to address this limitation, we present a workflow using porous silicon nanoneedles to repeatedly collect biomolecules from live brain tissues and map lipid distribution through desorption electrospray ionization mass spectrometry imaging. This method preserves the integrity of the original tissue while replicating its spatial molecular profile on the nanoneedle substrate, accurately reflecting lipid distribution and tissue morphology. Machine learning analysis of 23 human glioma biopsies demonstrated that nanoneedle sampling enables the precise classification of disease states. Furthermore, a spatiotemporal analysis of mouse gliomas treated with temozolomide revealed time- and treatment-dependent variations in lipid composition. Our approach enables non-destructive spatiotemporal lipidomics, advancing molecular diagnostics for precision medicine. Arrays of silicon nanoneedles are used to generate molecular replicas of live brain tissue for longitudinal spatial lipidomic classification via desorption electrospray ionization mass spectrometry imaging of gliomas and to monitor the responses of the tumours to chemotherapy.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 9","pages":"1262-1272"},"PeriodicalIF":34.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41565-025-01955-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144296081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymeric stabilization at the gas–liquid interface for durable solar hydrogen production from plastic waste 气液界面的聚合物稳定，用于从塑料废物中持久的太阳能制氢

IF 34.9 1区材料科学

Nature nanotechnology Pub Date : 2025-06-11 DOI: 10.1038/s41565-025-01957-6

Wang Hee Lee, Hyunseo Park, Chan Woo Lee, Haeseong Kim, Jae Hwan Jeong, Jeong In Yun, Seong-Uk Bang, Junhyeok Heo, Kyung Hyun Ahn, Gi Doo Cha, Megalamane S. Bootharaju, Byoung-Hoon Lee, Jaeyune Ryu, Minho Kim, Taeghwan Hyeon, Dae-Hyeong Kim

{"title":"Polymeric stabilization at the gas–liquid interface for durable solar hydrogen production from plastic waste","authors":"Wang Hee Lee, Hyunseo Park, Chan Woo Lee, Haeseong Kim, Jae Hwan Jeong, Jeong In Yun, Seong-Uk Bang, Junhyeok Heo, Kyung Hyun Ahn, Gi Doo Cha, Megalamane S. Bootharaju, Byoung-Hoon Lee, Jaeyune Ryu, Minho Kim, Taeghwan Hyeon, Dae-Hyeong Kim","doi":"10.1038/s41565-025-01957-6","DOIUrl":"10.1038/s41565-025-01957-6","url":null,"abstract":"Heterogeneous photocatalysis offers substantial potential for sustainable energy conversion, yet its industrial application is constrained by limited durability under stringent photochemical conditions. Achieving high photocatalytic activity often requires harsh reaction conditions, compromising catalyst stability and longevity. Here we propose a strategy involving polymeric stabilization of photocatalytic centres uniquely localized at the gas–liquid interface, substantially enhancing both the catalytic activity and stability. Applied to the photocatalytic conversion of plastic waste into solar hydrogen, this approach maintained its catalytic performance over 2 months under harsh conditions. Using 0.3 wt% dynamically stabilized atomic Pt/TiO2 photocatalysts and concentrated sunlight, we achieved a plastic reforming activity of 271 mmolH2 h−1 m−2. Scaling to 1 m2 under natural sunlight yielded a hydrogen production rate of 0.906 l per day from polyethylene terephthalate waste. Economic analysis and extensive-scale simulations suggest this strategy as a promising pathway for high-performance, durable photocatalysis, advancing renewable energy conversion. Polymeric stabilization of photocatalysts at the gas–liquid interface enhances both the catalytic activity and stability for solar hydrogen production from plastic waste. The photocatalyst retains its performance over 2 months under harsh conditions, and scaling to 1 m2 yields a hydrogen production rate of 0.906 l per day from polyethylene terephthalate waste under natural sunlight.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 9","pages":"1237-1246"},"PeriodicalIF":34.9,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144260563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrically reconfigurable heteronuclear dual-atom catalysts 电可重构异核双原子催化剂

IF 34.9 1区材料科学

Nature nanotechnology Pub Date : 2025-06-11 DOI: 10.1038/s41565-025-01948-7

Ning Han, Li-Hua Chen, Bao-Lian Su

引用次数: 0

Atomic manipulation of the emergent quasi-2D superconductivity and pair density wave in a kagome metal kagome金属中涌现的准二维超导性和对密度波的原子操纵

IF 34.9 1区材料科学

Nature nanotechnology Pub Date : 2025-06-10 DOI: 10.1038/s41565-025-01940-1

Xianghe Han, Hui Chen, Hengxin Tan, Zhongyi Cao, Zihao Huang, Yuhan Ye, Zhen Zhao, Chengmin Shen, Haitao Yang, Binghai Yan, Ziqiang Wang, Hong-Jun Gao

{"title":"Atomic manipulation of the emergent quasi-2D superconductivity and pair density wave in a kagome metal","authors":"Xianghe Han, Hui Chen, Hengxin Tan, Zhongyi Cao, Zihao Huang, Yuhan Ye, Zhen Zhao, Chengmin Shen, Haitao Yang, Binghai Yan, Ziqiang Wang, Hong-Jun Gao","doi":"10.1038/s41565-025-01940-1","DOIUrl":"10.1038/s41565-025-01940-1","url":null,"abstract":"The unconventional charge density wave (CDW) order in layered kagome lattice superconductors AV3Sb5 (A = K, Cs or Rb) triggers the emergence of novel quantum states such as time-reversal symmetry breaking and electronic liquid crystal states. However, atomic-scale manipulation and control of such phases remains elusive. Here we observe the emergent superconductivity and a primary pair density wave at the 2 × 2 Cs reconstructed surface of CsV3Sb5 by means of low-temperature scanning tunnelling microscopy/spectroscopy paired with density functional theory calculations. This quasi-two-dimensional kagome superconducting state with a critical temperature of ~5.4 K is intertwined with the bulk CDW order and exhibits a unique vortex core spectrum and a 4 × 4 pair density wave modulation of the superconducting gap. The emergent phenomena happen at a π-phase-shift dislocation in the periodicity of the CDW along the stacking direction if the 2 × 2 Cs superstructures are out of phase with the bulk CDW. Furthermore, we switched on and off the quasi-two-dimensional superconductivity through tip-assisted atomic manipulation of the 2 × 2 Cs superstructure. Thus, control of the surface reconstruction permits the creation, manipulation and control of quantum many-body states at antiphase boundaries in kagome lattice superconductors and, potentially, in other correlated materials. Scanning tunnelling microscopy experiments uncover a primary pair density wave at the reconstructed surface of the kagome metal CsV3Sb5, and tip-assisted, atomically precise manipulation of the reconstruction provides control over the emergent quasi-two-dimensional superconductivity.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 8","pages":"1017-1025"},"PeriodicalIF":34.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144252771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and opportunities in DNA computing and data storage DNA计算和数据存储的挑战和机遇

IF 34.9 1区材料科学

Nature nanotechnology Pub Date : 2025-06-10 DOI: 10.1038/s41565-025-01937-w

Stéphane D. Lemaire, David Turek, Dave Landsman, Marthe Colotte, Tom F. A. de Greef

引用次数: 0

Modulation of SARS-CoV-2 spike binding to ACE2 through conformational selection 通过构象选择调节SARS-CoV-2刺突与ACE2的结合

IF 34.9 1区材料科学

Nature nanotechnology Pub Date : 2025-06-10 DOI: 10.1038/s41565-025-01908-1

Prithwidip Saha, Ignacio Fernandez, Fidan Sumbul, Claire Valotteau, Dorota Kostrz, Annalisa Meola, Eduard Baquero, Arvind Sharma, James R. Portman, François Stransky, Thomas Boudier, Pablo Guardado-Calvo, Charlie Gosse, Terence Strick, Felix A. Rey, Felix Rico

{"title":"Modulation of SARS-CoV-2 spike binding to ACE2 through conformational selection","authors":"Prithwidip Saha, Ignacio Fernandez, Fidan Sumbul, Claire Valotteau, Dorota Kostrz, Annalisa Meola, Eduard Baquero, Arvind Sharma, James R. Portman, François Stransky, Thomas Boudier, Pablo Guardado-Calvo, Charlie Gosse, Terence Strick, Felix A. Rey, Felix Rico","doi":"10.1038/s41565-025-01908-1","DOIUrl":"10.1038/s41565-025-01908-1","url":null,"abstract":"The first step of SARS-CoV-2 infection involves the interaction between the viral trimeric spike protein (S) and the host angiotensin-converting enzyme 2 (ACE2). The receptor-binding domain (RBD) of S adopts two conformations: open and closed, respectively accessible and inaccessible to ACE2. Although these changes surely affect ACE2 binding, a quantitative description of the underlying mechanisms has remained elusive. Here we visualize RBD opening and closing using high-speed atomic force microscopy, gaining access to the corresponding transition rates. We also probe the S/ACE2 interaction at the ensemble level with biolayer interferometry and at the single-molecule level with atomic force microscopy and magnetic tweezers, evidencing that RBD dynamics hinder ACE2 binding but have no effect on unbinding. The resulting modulation is quantitatively predicted by a conformational selection model in which each S protomer behaves independently. Our work thus reveals a molecular mechanism by which RBD accessibility and binding strength can be tuned separately, providing hints to better understand the joint evolution of immune evasion and infectivity. This work uses single-molecule techniques to show that conformational changes of the spike protein of SARS-CoV-2 modulate binding to its human receptor. The study provides key insights into the molecular mechanisms of virus infection and immune evasion.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 7","pages":"926-934"},"PeriodicalIF":34.9,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144252772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0