Nature nanotechnology最新文献_第7页

Revealing the degradation pathways of layered Li-rich oxide cathodes 揭示层状富锂氧化物阴极的降解途径

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-09-02 DOI: 10.1038/s41565-024-01773-4

Zhimeng Liu, Yuqiang Zeng, Junyang Tan, Hailong Wang, Yudong Zhu, Xin Geng, Peter Guttmann, Xu Hou, Yang Yang, Yunkai Xu, Peter Cloetens, Dong Zhou, Yinping Wei, Jun Lu, Jie Li, Bilu Liu, Martin Winter, Robert Kostecki, Yuanjing Lin, Xin He

{"title":"Revealing the degradation pathways of layered Li-rich oxide cathodes","authors":"Zhimeng Liu, Yuqiang Zeng, Junyang Tan, Hailong Wang, Yudong Zhu, Xin Geng, Peter Guttmann, Xu Hou, Yang Yang, Yunkai Xu, Peter Cloetens, Dong Zhou, Yinping Wei, Jun Lu, Jie Li, Bilu Liu, Martin Winter, Robert Kostecki, Yuanjing Lin, Xin He","doi":"10.1038/s41565-024-01773-4","DOIUrl":"10.1038/s41565-024-01773-4","url":null,"abstract":"Layered lithium-rich transition metal oxides are promising cathode candidates for high-energy-density lithium batteries due to the redox contributions from transition metal cations and oxygen anions. However, their practical application is hindered by gradual capacity fading and voltage decay. Although oxygen loss and phase transformation are recognized as primary factors, the structural deterioration, chemical rearrangement, kinetic and thermodynamic effects remain unclear. Here we integrate analysis of morphological, structural and oxidation state evolution from individual atoms to secondary particles. By performing nanoscale to microscale characterizations, distinct structural change pathways associated with intraparticle heterogeneous reactions are identified. The high level of oxygen defects formed throughout the particle by slow electrochemical activation triggers progressive phase transformation and the formation of nanovoids. Ultrafast lithium (de)intercalation leads to oxygen-distortion-dominated lattice displacement, transition metal ion dissolution and lithium site variation. These inhomogeneous and irreversible structural changes are responsible for the low initial Coulombic efficiency, and ongoing particle cracking and expansion in the subsequent cycles. This work employs nano- to microscale characterization to identify different structural change pathways associated with non-homogeneous reactions within the particles, and explores differences in the failure mechanisms of lithium-rich transition metal oxide materials at different current densities.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 12","pages":"1821-1830"},"PeriodicalIF":38.1,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonlinear Hall effect in an insulator 绝缘体中的非线性霍尔效应

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-08-29 DOI: 10.1038/s41565-024-01755-6

Cheng-Ping Zhang, K. T. Law

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DNA nanoswitches pack an anti-cancer punch DNA 纳米开关可抗癌

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-08-29 DOI: 10.1038/s41565-024-01749-4

Kun Zhou, Chenxiang Lin

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Revisiting hyperbolic materials for deep-subwavelength polaritonics 重新审视用于深亚波长偏振电子学的双曲材料

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-08-29 DOI: 10.1038/s41565-024-01750-x

Seokwoo Kim, Yeongtae Jang, Junsuk Rho

引用次数: 0

Construction of topological quantum magnets from atomic spins on surfaces 利用表面原子自旋构建拓扑量子磁体

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-08-29 DOI: 10.1038/s41565-024-01775-2

Hao Wang, Peng Fan, Jing Chen, Lili Jiang, Hong-Jun Gao, Jose L. Lado, Kai Yang

{"title":"Construction of topological quantum magnets from atomic spins on surfaces","authors":"Hao Wang, Peng Fan, Jing Chen, Lili Jiang, Hong-Jun Gao, Jose L. Lado, Kai Yang","doi":"10.1038/s41565-024-01775-2","DOIUrl":"10.1038/s41565-024-01775-2","url":null,"abstract":"Artificial quantum systems have emerged as platforms to realize topological matter in a well-controlled manner. So far, experiments have mostly explored non-interacting topological states, and the realization of many-body topological phases in solid-state platforms with atomic resolution has remained challenging. Here we construct topological quantum Heisenberg spin lattices by assembling spin chains and two-dimensional spin arrays from spin-1/2 Ti atoms on an insulating MgO film in a scanning tunnelling microscope. We engineer both topological and trivial phases of the quantum spin model and thereby realize first- and second-order topological quantum magnets. We probe the many-body excitations of the quantum magnets by single-atom electron spin resonance with an energy resolution better than 100 neV. Making use of the atomically localized magnetic field of the scanning tunnelling microscope tip, we visualize various many-body topological bound modes including topological edge states, topological defects and higher-order corner modes. Our results provide a bottom-up approach for the simulation of exotic quantum many-body phases of interacting spins. Atom manipulation in a scanning tunnelling microscope allows the fabrication of artificial topological quantum magnets. Single-atom electron spin resonance experiments probe the many-body topological modes of the quantum magnets and provide a visualization.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 12","pages":"1782-1788"},"PeriodicalIF":38.1,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142090264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymer-locking fusogenic liposomes for glioblastoma-targeted siRNA delivery and CRISPR–Cas gene editing 用于胶质母细胞瘤靶向 siRNA 递送和 CRISPR-Cas 基因编辑的聚合物锁定熔融脂质体

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-08-29 DOI: 10.1038/s41565-024-01769-0

Yu Zhao, Jie Qin, Daohan Yu, Yuxiang Liu, Dan Song, Kaifu Tian, Hao Chen, Qile Ye, Xinyu Wang, Tianye Xu, Hanwen Xuan, Nan Sun, Wenbin Ma, Junzhe Zhong, Penggang Sun, Yu Song, Jingze Hu, Yunlei Zhao, Xintong Hou, Xiangqi Meng, Chuanlu Jiang, Jinquan Cai

{"title":"Polymer-locking fusogenic liposomes for glioblastoma-targeted siRNA delivery and CRISPR–Cas gene editing","authors":"Yu Zhao, Jie Qin, Daohan Yu, Yuxiang Liu, Dan Song, Kaifu Tian, Hao Chen, Qile Ye, Xinyu Wang, Tianye Xu, Hanwen Xuan, Nan Sun, Wenbin Ma, Junzhe Zhong, Penggang Sun, Yu Song, Jingze Hu, Yunlei Zhao, Xintong Hou, Xiangqi Meng, Chuanlu Jiang, Jinquan Cai","doi":"10.1038/s41565-024-01769-0","DOIUrl":"10.1038/s41565-024-01769-0","url":null,"abstract":"In patients with glioblastoma (GBM), upregulated midkine (MDK) limits the survival benefits conferred by temozolomide (TMZ). RNA interference (RNAi) and CRISPR–Cas9 gene editing technology are attractive approaches for regulating MDK expression. However, delivering these biologics to GBM tissue is challenging. Here we demonstrate a polymer-locking fusogenic liposome (Plofsome) that can be transported across the blood–brain barrier (BBB) and deliver short interfering RNA or CRISPR–Cas9 ribonucleoprotein complexes into the cytoplasm of GBM cells. Plofsome is designed by integrating a ‘lock’ into the fusogenic liposome using a traceless reactive oxygen species (ROS)-cleavable linker so that fusion occurs only after crossing the BBB and entering the GBM tissue with high ROS levels. Our results showed that MDK suppression by Plofsomes significantly reduced TMZ resistance and inhibited GBM growth in orthotopic brain tumour models. Importantly, Plofsomes are effective only at tumour sites and not in normal tissues, which improves the safety of combined RNAi and CRISPR–Cas9 therapeutics. Delivering gene editing materials to the brain for glioblastoma therapy can boost the efficacy of chemotherapy. Here the authors reduce resistance to temozolomide using a reactive oxygen species-sensitive polymer-locking fusogenic liposome that can cross the blood–brain barrier and deliver short interfering RNA or CRISPR–Cas to glioblastoma with high specificity.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 12","pages":"1869-1879"},"PeriodicalIF":38.1,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142090263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bottom-up synthetic immunology 自下而上的合成免疫学。

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-08-26 DOI: 10.1038/s41565-024-01744-9

Kerstin Göpfrich, Michael Platten, Friedrich Frischknecht, Oliver T. Fackler

{"title":"Bottom-up synthetic immunology","authors":"Kerstin Göpfrich, Michael Platten, Friedrich Frischknecht, Oliver T. Fackler","doi":"10.1038/s41565-024-01744-9","DOIUrl":"10.1038/s41565-024-01744-9","url":null,"abstract":"Infectious diseases and cancer evade immune surveillance using similar mechanisms. Targeting immune mechanisms using common strategies thus represents a promising avenue to improve prevention and treatment. Synthetic immunology can provide such strategies by applying engineering principles from synthetic biology to immunology. Synthetic biologists engineer cells by top-down genetic manipulation or bottom-up assembly from nanoscale building blocks. Recent successes in treating advanced tumours and diseases using genetically engineered immune cells highlight the power of the top-down synthetic immunology approach. However, genetic immune engineering is mostly limited to ex vivo applications and is subject to complex counter-regulation inherent to immune functions. Bottom-up synthetic biology can harness the rich nanotechnology toolbox to engineer molecular and cellular systems from scratch and equip them with desired functions. These are beginning to be tailored to perform targeted immune functions and should hence allow intervention strategies by rational design. In this Perspective we conceptualize bottom-up synthetic immunology as a new frontier field that uses nanotechnology for crucial innovations in therapy and the prevention of infectious diseases and cancer. This Perspective highlights bottom-up molecular engineering and modular nanobiotechnological approaches for developing effective immunotherapeutics and their potential in personalized medicine.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 11","pages":"1587-1596"},"PeriodicalIF":38.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal-ion-chelating phenylalanine nanostructures reverse immune dysfunction and sensitize breast tumour to immune checkpoint blockade 金属离子螯合苯丙氨酸纳米结构可逆转免疫功能障碍，并使乳腺肿瘤对免疫检查点阻断剂敏感。

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-08-26 DOI: 10.1038/s41565-024-01758-3

Mixiao Tan, Guoliang Cao, Rupeng Wang, Long Cheng, Wenping Huang, Yue Yin, Haixia Ma, Shih-Hsin Ho, Zhigang Wang, Motao Zhu, Haitao Ran, Guangjun Nie, Hai Wang

{"title":"Metal-ion-chelating phenylalanine nanostructures reverse immune dysfunction and sensitize breast tumour to immune checkpoint blockade","authors":"Mixiao Tan, Guoliang Cao, Rupeng Wang, Long Cheng, Wenping Huang, Yue Yin, Haixia Ma, Shih-Hsin Ho, Zhigang Wang, Motao Zhu, Haitao Ran, Guangjun Nie, Hai Wang","doi":"10.1038/s41565-024-01758-3","DOIUrl":"10.1038/s41565-024-01758-3","url":null,"abstract":"An immunosuppressive tumour microenvironment strongly influences response rates in patients receiving immune checkpoint blockade-based cancer immunotherapies, such as programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1). Here we demonstrate that metal-ion-chelating l-phenylalanine nanostructures synergize with short-term starvation (STS) to remodel the immunosuppressive microenvironment of breast and colorectal tumours. These nanostructures modulate the electrophysiological behaviour of dendritic cells and activate them through the NLRP3 inflammasome and calcium-mediated nuclear factor-κB pathway. STS promotes the cellular uptake of nanostructures through amino acid transporters and plays a key role in dendritic cell maturation and tumour-specific cytotoxic T lymphocyte responses. This study demonstrates the potential role of metal-ion-chelating l-phenylalanine nanostructures in activating immune responses and the effect of STS treatment in improving nanomaterial-mediated cancer immunotherapy. Metal-ion-chelating phenylalanine nanostructures modulate ion influx and efflux in dendritic cells, activating them through the NLRP3 inflammasome and NF-κB pathway to remodel the immunosuppressive tumour microenvironment for PD-L1-based immunotherapy.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 12","pages":"1903-1913"},"PeriodicalIF":38.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topotaxial mutual-exchange growth of magnetic Zintl Eu3In2As4 nanowires with axion insulator classification 具有轴向绝缘体分类的磁性 Zintl Eu3In2As4 纳米线的顶轴相互交换生长。

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-08-26 DOI: 10.1038/s41565-024-01762-7

Man Suk Song, Lothar Houben, Yufei Zhao, Hyeonhu Bae, Nadav Rothem, Ambikesh Gupta, Binghai Yan, Beena Kalisky, Magdalena Zaluska-Kotur, Perla Kacman, Hadas Shtrikman, Haim Beidenkopf

{"title":"Topotaxial mutual-exchange growth of magnetic Zintl Eu3In2As4 nanowires with axion insulator classification","authors":"Man Suk Song, Lothar Houben, Yufei Zhao, Hyeonhu Bae, Nadav Rothem, Ambikesh Gupta, Binghai Yan, Beena Kalisky, Magdalena Zaluska-Kotur, Perla Kacman, Hadas Shtrikman, Haim Beidenkopf","doi":"10.1038/s41565-024-01762-7","DOIUrl":"10.1038/s41565-024-01762-7","url":null,"abstract":"Due to quasi-one-dimensional confinement, nanowires possess unique electronic properties, which can promote specific device architectures. However, nanowire growth presents paramount challenges, limiting the accessible crystal structures and elemental compositions. Here we demonstrate solid-state topotactic exchange that converts wurtzite InAs nanowires into Zintl Eu3In2As4. Molecular-beam-epitaxy-based in situ evaporation of Eu and As onto InAs nanowires results in the mutual exchange of Eu from the shell and In from the core. Therefore, a single-phase Eu3In2As4 shell grows, which gradually consumes the InAs core. The mutual exchange is supported by the substructure of the As matrix, which is similar across the wurtzite InAs and Zintl Eu3In2As4 and therefore is topotactic. The Eu3In2As4 nanowires undergo an antiferromagnetic transition at a Néel temperature of ~6.5 K. Ab initio calculations confirm the antiferromagnetic ground state and classify Eu3In2As4 as a C2T axion insulator, hosting both chiral hinge modes and unpinned Dirac surface states. The topotactic mutual-exchange nanowire growth will, thus, enable the exploration of intricate magneto-topological states in Eu3In2As4 and potentially in other exotic compounds. In situ evaporation of Eu and As onto InAs nanowires results in the mutual exchange of Eu from the shell with In from the core. This solid-state exchange reaction converts wurtzite InAs nanowires into Zintl Eu3In2As4.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 12","pages":"1796-1803"},"PeriodicalIF":38.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous spectral and coupling-strength encoding with dual-gradient metasurfaces 双梯度元曲面的连续谱和耦合强度编码。

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2024-08-26 DOI: 10.1038/s41565-024-01767-2

Andreas Aigner, Thomas Weber, Alwin Wester, Stefan A. Maier, Andreas Tittl

{"title":"Continuous spectral and coupling-strength encoding with dual-gradient metasurfaces","authors":"Andreas Aigner, Thomas Weber, Alwin Wester, Stefan A. Maier, Andreas Tittl","doi":"10.1038/s41565-024-01767-2","DOIUrl":"10.1038/s41565-024-01767-2","url":null,"abstract":"To control and enhance light–matter interactions at the nanoscale, two parameters are central: the spectral overlap between an optical cavity mode and the material’s spectral features (for example, excitonic or molecular absorption lines), and the quality factor of the cavity. Controlling both parameters simultaneously would enable the investigation of systems with complex spectral features, such as multicomponent molecular mixtures or heterogeneous solid-state materials. So far, it has been possible only to sample a limited set of data points within this two-dimensional parameter space. Here we introduce a nanophotonic approach that can simultaneously and continuously encode the spectral and quality-factor parameter space within a compact spatial area. We use a dual-gradient metasurface design composed of a two-dimensional array of smoothly varying subwavelength nanoresonators, each supporting a unique mode based on symmetry-protected bound states in the continuum. This results in 27,500 distinct modes and a mode density approaching the theoretical upper limit for metasurfaces. By applying our platform to surface-enhanced molecular spectroscopy, we find that the optimal quality factor for maximum sensitivity depends on the amount of analyte, enabling effective molecular detection regardless of analyte concentration within a single dual-gradient metasurface. Our design provides a method to analyse the complete spectral and coupling-strength parameter space of complex material systems for applications such as photocatalysis, chemical sensing and entangled photon generation. A dual-gradient metasurface is introduced that allows continuous control over light–matter coupling in the spectral and quality-factor parameter space. Used for molecular sensing, it achieves mode densities near the theoretical limit for metasurfaces.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 12","pages":"1804-1812"},"PeriodicalIF":38.1,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41565-024-01767-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0