Nature nanotechnology最新文献

{"title":"A high-fibre diet-derived microbial polyphenol metabolite boosts T-cell stemness in cancer immunotherapy","authors":"Anni A. Zhang, Ian A. Parish","doi":"10.1038/s41565-026-02246-6","DOIUrl":"10.1038/s41565-026-02246-6","url":null,"abstract":"3,4-dihydroxybenzoic acid (DHB), a molecule produced by the gut microbiota from dietary fibre, promotes T cell stemness and boosts the anti-tumour efficacy of immunotherapies in multiple mouse tumour models.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"21 9","pages":"1224-1225"},"PeriodicalIF":37.5,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral nano-delivery of a gut microbial metabolite enhances T cell stemness for cancer immunotherapy","authors":"Kai Han, Young Seok Cho, Mariko Takahashi, Xingwu Zhou, Hannah E. Dobson, Kim Hutchings, Yuesong Wu, Youngseo Na, Fang Xie, Julia Crowther, Jinmei Wu, Jin Xu, Chuan Lee, Himani Jasewicz, Yujin Kim, Minal Nenwani, Olamide Animasahun, Fulei Wuchu, Anthony Andren, Harrison Wong, Emma Camp, Ziye Wan, Qi Wu, Li Zhang, Cheng Xu, Katherine Dong, Yao Xu, Anna Schwendeman, Grace Y. Chen, Yuying Xie, Costas A. Lyssiotis, Martin Clasby, Deepak Nagrath, Yu Leo Lei, James J. Moon","doi":"10.1038/s41565-026-02235-9","DOIUrl":"10.1038/s41565-026-02235-9","url":null,"abstract":"Gut microbial metabolites play crucial roles in regulating systemic immunity, but their mechanisms and limited drug-like properties remain unresolved. Here we report an oral nano-formulation that leverages gut microbial metabolites to modulate T cell metabolism and amplify antitumour immunity. Through an in vitro screening of gut microbial metabolites, we identified 3,4-dihydroxybenzoic acid that improved adoptive T cell therapy and enhanced CD8+ T cell stemness by suppressing glycolysis and regulating the Akt-mTORC1-Myc pathway. To harness the potency of 3,4-dihydroxybenzoic acid for systemic cancer immunotherapy, we engineered a 3,4-dihydroxybenzoic acid prodrug nano-emulsion, significantly increasing its oral absorption and half-life. In multiple murine tumour models, the oral nano-emulsion enhanced the expansion of antigen-specific, stem-like CD8+ T cells, sensitizing tumours to anti-PD-1 blockade and exerting robust antitumour efficacy. By integrating nanotechnology with microbial-metabolite-based immunotherapy, this study establishes a mechanistic link between the gut microbiota and T cell immunity, offering a promising approach for cancer immunotherapy. A nano-emulsion that delivers the gut microbial metabolite 3,4-dihydroxybenzoic acid in a prodrug form enhances T cell stemness and boosts the efficacy of immunotherapy approaches in different murine cancer models.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"21 9","pages":"1338-1349"},"PeriodicalIF":37.5,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41565-026-02235-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Black phosphorus nanosheets boost mitochondrial oxidative phosphorylation improving immunotherapy outcomes","authors":"Yuedi Yang, Mingda Zhao, Jiadong Li, Ruiling Xu, Jie Liang, Qing Jiang, Xingchen Peng, Aiping Tong, Li Min, Yunfeng Lin, Xingdong Zhang, Yujiang Fan, Yong Sun","doi":"10.1038/s41565-026-02248-4","DOIUrl":"10.1038/s41565-026-02248-4","url":null,"abstract":"","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"21 9","pages":"1350-1350"},"PeriodicalIF":37.5,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41565-026-02248-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectral biophysical cytometry with nanosensors reveals remodelling of immune cells in atherosclerosis","authors":"Cenk O. Gurdap, Dunya Aydos, Luca A. Andronico, Gábor Tóth, Tugce Ceker, John Cowgill, Irem Muge Akbulut Koyuncu, Neslihan Basak, Jaromir Mikes, Andrey S. Klymchenko, Federico Pietrocola, Petter Brodin, Ingela Lanekoff, Verda Ceylan Bitirim, Erdinc Sezgin","doi":"10.1038/s41565-026-02236-8","DOIUrl":"10.1038/s41565-026-02236-8","url":null,"abstract":"The biophysical properties of cells determine cellular physiology. Leveraging these properties for biomedical applications demands the ability to measure multiple parameters simultaneously across millions of cells and diverse cell types. However, current technologies are limited by throughput and low dimensionality. Here we introduce spectral biophysical cytometry (SBC), a high-throughput platform that integrates environment-sensitive nanosensors with spectral flow cytometry to resolve multiparametric biophysical properties of immune cells at single-cell resolution. By using fluorescent nanosensors that report membrane order, mitochondrial potential and membrane potential, SBC enables simultaneous quantification of key cellular physical states across diverse immune cell populations. When applied to peripheral blood mononuclear cells, SBC reveals cell-type-specific biophysical heterogeneity and identifies distinct remodelling signatures associated with atherosclerosis. In particular, T-cell subsets exhibit substantial alterations in membrane order and mitochondrial depolarization, reflecting coordinated changes in lipid composition and metabolic pathways. Integration with lipidomics and transcriptomics demonstrates that the nanosensors can detect biophysical shifts that correlate with dysregulated lipid metabolism and mitochondrial function, providing mechanistic insight into immune dysfunction in disease. Importantly, SBC achieves rapid, label-efficient profiling using commercially available instrumentation, enabling scalable biomarker discovery directly from blood samples and establishing a powerful strategy for linking biophysical phenotypes to immune cell function. Membrane-permeant, environment-sensitive nanosensors enable high-throughput, multiparametric quantification of membrane order and mitochondrial potential, revealing immune-cell-specific remodelling and lipid-metabolic dysfunction in atherosclerosis.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"21 9","pages":"1308-1315"},"PeriodicalIF":37.5,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41565-026-02236-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radial nanochannel-array carbon enables high-performance intermetallic fuel cell catalysts","authors":"Lei Gao, Sooyeon Hwang, Xiaorui Li, Jiamao Zheng, Kwanpyung Lee, Shuo Liu, Dominik Wierzbicki, Jialu Li, Jinghua Guo, Bingzhang Zhang, Honghong Lin, Qing Zhao, Guofeng Wang, Chaochao Dun, Gang Wu","doi":"10.1038/s41565-026-02244-8","DOIUrl":"10.1038/s41565-026-02244-8","url":null,"abstract":"The challenge of designing platinum-based intermetallic catalysts for oxygen-reduction cathodes in fuel cells is to synergistically integrate four critical merits into one catalyst, including fine metal nanoparticles, high ordering degree of intermetallic structure, high Pt content against support and mesopore-rich carbon supports for favourable ionomer dispersion and mass/charge transfers. Here we introduce a radial nanochannel-array carbon sphere (RNCS) support that contains open-through-grooved mesopores with sufficient volume and optimal size. PtCo intermetallic nanoparticles are uniformly assembled into the RNCS to achieve exceptional thermal and electrochemical stability. Annealing at desirable elevated temperatures (>1,000 °C) simultaneously yields highly ordered L10-PtCo intermetallic phases (>80%) and fine particle dispersion (<5 nm), even at a high Pt content of 40 wt%. The RNCS support enables all these merits in a single catalyst due to its ordered mesoporous structures with effective nanoconfinement, and the supported PtCo intermetallic catalyst in membrane electrode assemblies delivered a compelling current density of 2.12 A cm−2 at 0.70 V under heavy-duty vehicle conditions and retained 82.5% performance after a rigorous accelerated stress test of 150,000-voltage cycles. Hollow nanocarbon spheres containing an ordered radial nanochannel array were used as supports to design high-performance intermetallic nanoparticle fuel cell catalysts. They overcome the trade-off between the degree of ordering in the intermetallic phase and nanoparticle dispersion.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"21 9","pages":"1259-1269"},"PeriodicalIF":37.5,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A charged cage for excitons","authors":"Florian Dirnberger, Jonas D. Ziegler","doi":"10.1038/s41565-026-02240-y","DOIUrl":"10.1038/s41565-026-02240-y","url":null,"abstract":"Nanoporous monolayer metal enables 0D quantum confinement of charged quasiparticles in a monolayer semiconductor.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"21 8","pages":"1062-1063"},"PeriodicalIF":37.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148679552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrostatic quantum nanocorral for composite charged excitons","authors":"Zhe Sun, Mohamed Shehabeldin, Jian Tang, Mingyang Guo, Zumeng Huang, Tianxing Tang, Tiema Qian, Vsevolod Belosevich, Thomas Siyuan Ding, Jingdi Tang, Yangchen He, Ivona Košić, Michael Geiwitz, Kenji Watanabe, Takashi Taniguchi, Kenneth Stephen Burch, Efrén Navarro-Moratalla, Daniel Rhodes, Chun Hung Lui, Ni Ni, Su-Yang Xu, Qiong Ma","doi":"10.1038/s41565-026-02222-0","DOIUrl":"10.1038/s41565-026-02222-0","url":null,"abstract":"A tunable interface between flying photons and stationary quantum states is important for quantum networks. Quantum-confined charged excitons are attractive in this context because they combine single-photon emission with localized charge states. However, realizing nanoscale electrostatic confinement that is reversible, robust and spectroscopically resolvable remains challenging. Here we show luminous, quantum-confined charged excitons in monolayer WSe2 using an electrostatic quantum nanocorral. A quantum corral was first realized using scanning tunnelling microscopy, where individual adatoms are arranged in a ring on a metal surface to confine electronic standing waves. In our approach, monolayer WSe2 is gated through a nanoporous metallic monolayer less than 1-nm thick, which acts as an electric-field mask and defines confinement on ~10-nm length scales. This geometry creates distinct excitonic quasiparticle states inside and outside the nanopore, with ultrabright charged excitons confined by surrounding higher-energy neutral-exciton states. The resulting confinement produces pronounced energy splittings and clear spectroscopic signatures of discrete centre-of-mass modes. The electrostatic barrier is dynamically reconfigurable, allowing a crossover between zero- and two-dimensional excitonic states, while polarization-resolved measurements reveal signatures of fine-structure splitting. These results establish an electrically tunable route to controlling charged excitons for quantum light sources with adjustable brightness, energy and photon statistics. An electrostatic excitonic corral in nanoporous-metal-defined monolayer WSe2 achieves quantum confinement of charged excitons, generating discrete energy levels and tunable transitions between localized and extended states.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"21 8","pages":"1097-1104"},"PeriodicalIF":37.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148679535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecules under controlled collapse","authors":"Zuchong Yang, Emanuele Orgiu","doi":"10.1038/s41565-026-02234-w","DOIUrl":"10.1038/s41565-026-02234-w","url":null,"abstract":"A novel platform based on standard semiconductor processing combined with a deterministic collapse strategy can lead to pristine and self-aligned interfaces with molecules.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"21 9","pages":"1222-1223"},"PeriodicalIF":37.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-assembled contacts for high-yield molecular devices","authors":"Sarah O. Spector, Peter F. Satterthwaite, Maxwell Conte, Teddy Hsieh, Eduard O. Bobylev, Kieran Dunn, Weikun Zhu, Jinwoo Sim, Jeremiah A. Johnson, Farnaz Niroui","doi":"10.1038/s41565-026-02227-9","DOIUrl":"10.1038/s41565-026-02227-9","url":null,"abstract":"With their atomic precision and synthetically tailorable properties, molecules offer new possibilities for emerging computing, sensing, optical and quantum technologies. However, the scalable, damage-free integration of molecules into active devices with atomic-scale control remains a critical challenge due to incompatibility with existing top-down fabrication processes. Here we introduce self-assembled contacts, a strategy in which device structures are first fabricated using standard semiconductor manufacturing processes and subsequently transformed through engineered surface interactions to form self-aligned, pristine interfaces with molecules. We validate this approach by fabricating over 1,000 electrically active metal–molecule–metal devices with yields of up to 99% and stable operation over 105 measurement cycles, even for molecular layers thinner than 1 nm. In situ Raman measurements verified the preservation of molecular integrity. Beyond individual devices, the platform supports system-level integration, which we demonstrate through vector-matrix multiplication, a fundamental operation in neuromorphic computing, implemented in a crossbar array of self-rectified molecular memory devices. Our results establish self-assembled contacts as a scalable platform for integrating molecular functionalities into devices, bridging self-assembly and top-down manufacturing. A soft contact approach enables scalable, damage-free integration of molecular materials into electronic devices using only conventional semiconductor manufacturing processes.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"21 9","pages":"1252-1258"},"PeriodicalIF":37.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic plasmon canalization in the biaxial van der Waals crystal MoOCl2","authors":"Farid Aghashirinov, Andrea Mancini, Lin Nan, Giacomo Venturi, Bettina Frank, Harald Giessen, Antonio Ambrosio","doi":"10.1038/s41565-026-02243-9","DOIUrl":"10.1038/s41565-026-02243-9","url":null,"abstract":"Anisotropic polaritons in low-symmetry crystals allow for subwavelength confinement and directional routing of light. The most extreme form of such anisotropy arises at the topological transition between elliptical and hyperbolic dispersion, where the isofrequency contours collapse into parallel lines and polaritons propagate in a diffractionless, beam-like fashion. This canalization regime has previously been accessed through twisted heterostructures or engineered metasurfaces. Here we show that intrinsic canalization can be achieved without any fabrication or structuring by exploiting the intrinsic elliptical-to-hyperbolic transition in the van der Waals crystal MoOCl2 at room temperature. Using near-field imaging, we directly visualize plasmon-polariton canalization emerging at the low-loss Drude crossing point along the [010] crystal axis. Owing to the moderate slope of the Drude permittivity, the resulting polaritons remain highly directional across a broad spectral window. This weak dispersion also enables robust thickness-dependent tuning, and we demonstrate, both experimentally and theoretically, that the canalization wavelength can be adjusted by more than 1 μm simply by varying the flake thickness. This work brings canalized polariton propagation into the 4.5–6 μm range, beyond the frequency limits of phonon–polariton platforms and overlapping with important molecular vibrations, opening new opportunities for mid-infrared nanophotonics and sensing. Near the Drude zero crossing where one in-plane permittivity component changes sign, the biaxial crystal MoOCl2 supports intrinsic diffraction-free canalized plasmon polaritons at wavelengths that are controlled by flake thickness.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"21 9","pages":"1238-1244"},"PeriodicalIF":37.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41565-026-02243-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}