Han-Ming Hau, Tara Mishra, Colin Ophus, Tzu-Yang Huang, Karen Bustilo, Yingzhi Sun, Xiaochen Yang, Tucker Holstun, Xinye Zhao, Shilong Wang, Yang Ha, Gi-Hyeok Lee, Chengyu Song, John Turner, Jianming Bai, Lu Ma, Ke Chen, Feng Wang, Wanli Yang, Bryan D. McCloskey, Zijian Cai, Gerbrand Ceder
{"title":"Earth-abundant Li-ion cathode materials with nanoengineered microstructures","authors":"Han-Ming Hau, Tara Mishra, Colin Ophus, Tzu-Yang Huang, Karen Bustilo, Yingzhi Sun, Xiaochen Yang, Tucker Holstun, Xinye Zhao, Shilong Wang, Yang Ha, Gi-Hyeok Lee, Chengyu Song, John Turner, Jianming Bai, Lu Ma, Ke Chen, Feng Wang, Wanli Yang, Bryan D. McCloskey, Zijian Cai, Gerbrand Ceder","doi":"10.1038/s41565-024-01787-y","DOIUrl":"https://doi.org/10.1038/s41565-024-01787-y","url":null,"abstract":"<p>Manganese-based materials have tremendous potential to become the next-generation lithium-ion cathode as they are Earth abundant, low cost and stable. Here we show how the mobility of manganese cations can be used to obtain a unique nanosized microstructure in large-particle-sized cathode materials with enhanced electrochemical properties. By combining atomic-resolution scanning transmission electron microscopy, four-dimensional scanning electron nanodiffraction and in situ X-ray diffraction, we show that when a partially delithiated, high-manganese-content, disordered rocksalt cathode is slightly heated, it forms a nanomosaic of partially ordered spinel domains of 3–7 nm in size, which impinge on each other at antiphase boundaries. The short coherence length of these domains removes the detrimental two-phase lithiation reaction present near 3 V in a regular spinel and turns it into a solid solution. This nanodomain structure enables good rate performance and delivers 200 mAh g<sup>−1</sup> discharge capacity in a (partially) disordered material with an average primary particle size of <span>∼</span>5 µm. The work not only expands the synthesis strategies available for developing high-performance Earth-abundant manganese-based cathodes but also offers structural insights into the ability to nanoengineer spinel-like phases.</p>","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"333 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cassian Afting, Tobias Walther, Oliver M. Drozdowski, Christina Schlagheck, Ulrich S. Schwarz, Joachim Wittbrodt, Kerstin Göpfrich
{"title":"DNA microbeads for spatio-temporally controlled morphogen release within organoids","authors":"Cassian Afting, Tobias Walther, Oliver M. Drozdowski, Christina Schlagheck, Ulrich S. Schwarz, Joachim Wittbrodt, Kerstin Göpfrich","doi":"10.1038/s41565-024-01779-y","DOIUrl":"https://doi.org/10.1038/s41565-024-01779-y","url":null,"abstract":"<p>Organoids are transformative in vitro model systems that mimic features of the corresponding tissue in vivo. However, across tissue types and species, organoids still often fail to reach full maturity and function because biochemical cues cannot be provided from within the organoid to guide their development. Here we introduce nanoengineered DNA microbeads with tissue mimetic tunable stiffness for implementing spatio-temporally controlled morphogen gradients inside of organoids at any point in their development. Using medaka retinal organoids and early embryos, we show that DNA microbeads can be integrated into embryos and organoids by microinjection and erased in a non-invasive manner with light. Coupling a recombinant surrogate Wnt to the DNA microbeads, we demonstrate the spatio-temporally controlled morphogen release from the microinjection site, which leads to morphogen gradients resulting in the formation of retinal pigmented epithelium while maintaining neuroretinal cell types. Thus, we bioengineered retinal organoids to more closely mirror the cell type diversity of in vivo retinae. Owing to the facile, one-pot fabrication process, the DNA microbead technology can be adapted to other organoid systems for improved tissue mimicry.</p>","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"72 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142158994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wang Zhang, Jiakang Min, Hao Wang, Hongtao Wang, Xue Liang Li, Son Tung Ha, Biao Zhang, Cheng-Feng Pan, Hao Li, Hailong Liu, Hui Yin, Xiaolong Yang, Siqi Liu, Xiaodong Xu, Chaobin He, Hui Ying Yang, Joel K. W. Yang
{"title":"Printing of 3D photonic crystals in titania with complete bandgap across the visible spectrum","authors":"Wang Zhang, Jiakang Min, Hao Wang, Hongtao Wang, Xue Liang Li, Son Tung Ha, Biao Zhang, Cheng-Feng Pan, Hao Li, Hailong Liu, Hui Yin, Xiaolong Yang, Siqi Liu, Xiaodong Xu, Chaobin He, Hui Ying Yang, Joel K. W. Yang","doi":"10.1038/s41565-024-01780-5","DOIUrl":"https://doi.org/10.1038/s41565-024-01780-5","url":null,"abstract":"<p>A photonic bandgap is a range of wavelengths wherein light is forbidden from entering a photonic crystal, similar to the electronic bandgap in semiconductors. Fabricating photonic crystals with a complete photonic bandgap in the visible spectrum presents at least two important challenges: achieving a material refractive index > ~2 and a three-dimensional patterning resolution better than ~280 nm (lattice constant of 400 nm). Here we show an approach to overcome such limitations using additive manufacturing, thus realizing high-quality, high-refractive index photonic crystals with size-tunable bandgaps across the visible spectrum. We develop a titanium ion-doped resin (Ti-Nano) for high-resolution printing by two-photon polymerization lithography. After printing, the structures are heat-treated in air to induce lattice shrinkage and produce titania nanostructures. We attain three-dimensional photonic crystals with patterning resolution as high as 180 nm and refractive index of 2.4–2.6. Optical characterization reveals ~100% reflectance within the photonic crystal bandgap in the visible range. Finally, we show capabilities in defining local defects and demonstrate proof-of-principle applications in spectrally selective perfect reflectors and chiral light discriminators.</p>","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"47 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142158993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paul Joyce, Christine J. Allen, María José Alonso, Marianne Ashford, Michelle S. Bradbury, Matthieu Germain, Maria Kavallaris, Robert Langer, Twan Lammers, Maria Teresa Peracchia, Amirali Popat, Clive A. Prestidge, Cristianne J. F. Rijcken, Bruno Sarmento, Ruth B. Schmid, Avi Schroeder, Santhni Subramaniam, Chelsea R. Thorn, Kathryn A. Whitehead, Chun-Xia Zhao, Hélder A. Santos
{"title":"A translational framework to DELIVER nanomedicines to the clinic","authors":"Paul Joyce, Christine J. Allen, María José Alonso, Marianne Ashford, Michelle S. Bradbury, Matthieu Germain, Maria Kavallaris, Robert Langer, Twan Lammers, Maria Teresa Peracchia, Amirali Popat, Clive A. Prestidge, Cristianne J. F. Rijcken, Bruno Sarmento, Ruth B. Schmid, Avi Schroeder, Santhni Subramaniam, Chelsea R. Thorn, Kathryn A. Whitehead, Chun-Xia Zhao, Hélder A. Santos","doi":"10.1038/s41565-024-01754-7","DOIUrl":"10.1038/s41565-024-01754-7","url":null,"abstract":"Nanomedicines have created a paradigm shift in healthcare. Yet fundamental barriers still exist that prevent or delay the clinical translation of nanomedicines. Critical hurdles inhibiting clinical success include poor understanding of nanomedicines’ physicochemical properties, limited exposure in the cell or tissue of interest, poor reproducibility of preclinical outcomes in clinical trials, and biocompatibility concerns. Barriers that delay translation include industrial scale-up or scale-down and good manufacturing practices, funding and navigating the regulatory environment. Here we propose the DELIVER framework comprising the core principles to be realized during preclinical development to promote clinical investigation of nanomedicines. The proposed framework comes with design, experimental, manufacturing, preclinical, clinical, regulatory and business considerations, which we recommend investigators to carefully review during early-stage nanomedicine design and development to mitigate risk and enable timely clinical success. By reducing development time and clinical trial failure, it is envisaged that this framework will help accelerate the clinical translation and maximize the impact of nanomedicines. The authors propose a framework to be followed during preclinical investigation of nanomedicines to increase their translatability potential.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 11","pages":"1597-1611"},"PeriodicalIF":38.1,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142142759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kangfan Ji, Xiangqian Wei, Anna R. Kahkoska, Juan Zhang, Yang Zhang, Jianchang Xu, Xinwei Wei, Wei Liu, Yanfang Wang, Yuejun Yao, Xuehui Huang, Shaoqian Mei, Yun Liu, Shiqi Wang, Zhengjie Zhao, Ziyi Lu, Jiahuan You, Guangzheng Xu, Youqing Shen, John. B. Buse, Jinqiang Wang, Zhen Gu
{"title":"An orally administered glucose-responsive polymeric complex for high-efficiency and safe delivery of insulin in mice and pigs","authors":"Kangfan Ji, Xiangqian Wei, Anna R. Kahkoska, Juan Zhang, Yang Zhang, Jianchang Xu, Xinwei Wei, Wei Liu, Yanfang Wang, Yuejun Yao, Xuehui Huang, Shaoqian Mei, Yun Liu, Shiqi Wang, Zhengjie Zhao, Ziyi Lu, Jiahuan You, Guangzheng Xu, Youqing Shen, John. B. Buse, Jinqiang Wang, Zhen Gu","doi":"10.1038/s41565-024-01764-5","DOIUrl":"https://doi.org/10.1038/s41565-024-01764-5","url":null,"abstract":"<p>Contrary to current insulin formulations, endogenous insulin has direct access to the portal vein, regulating glucose metabolism in the liver with minimal hypoglycaemia. Here we report the synthesis of an amphiphilic diblock copolymer comprising a glucose-responsive positively charged segment and polycarboxybetaine. The mixing of this polymer with insulin facilitates the formation of worm-like micelles, achieving highly efficient absorption by the gastrointestinal tract and the creation of a glucose-responsive reservoir in the liver. Under hyperglycaemic conditions, the polymer triggers a rapid release of insulin, establishing a portal-to-peripheral insulin gradient—similarly to endogenous insulin—for the safe regulation of blood glucose. This insulin formulation exhibits a dose-dependent blood-glucose-regulating effect in a streptozotocin-induced mouse model of type 1 diabetes and controls the blood glucose at normoglycaemia for one day in non-obese diabetic mice. In addition, the formulation demonstrates a blood-glucose-lowering effect for one day in a pig model of type 1 diabetes without observable hypoglycaemia, showing promise for the safe and effective management of type 1 diabetes.</p>","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"37 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhimeng Liu, Yuqiang Zeng, Junyang Tan, Hailong Wang, Yudong Zhu, Xin Geng, Peter Guttmann, Xu Hou, Yang Yang, Yunkai Xu, Peter Cloetens, Dong Zhou, Yinping Wei, Jun Lu, Jie Li, Bilu Liu, Martin Winter, Robert Kostecki, Yuanjing Lin, Xin He
{"title":"Revealing the degradation pathways of layered Li-rich oxide cathodes","authors":"Zhimeng Liu, Yuqiang Zeng, Junyang Tan, Hailong Wang, Yudong Zhu, Xin Geng, Peter Guttmann, Xu Hou, Yang Yang, Yunkai Xu, Peter Cloetens, Dong Zhou, Yinping Wei, Jun Lu, Jie Li, Bilu Liu, Martin Winter, Robert Kostecki, Yuanjing Lin, Xin He","doi":"10.1038/s41565-024-01773-4","DOIUrl":"https://doi.org/10.1038/s41565-024-01773-4","url":null,"abstract":"<p>Layered lithium-rich transition metal oxides are promising cathode candidates for high-energy-density lithium batteries due to the redox contributions from transition metal cations and oxygen anions. However, their practical application is hindered by gradual capacity fading and voltage decay. Although oxygen loss and phase transformation are recognized as primary factors, the structural deterioration, chemical rearrangement, kinetic and thermodynamic effects remain unclear. Here we integrate analysis of morphological, structural and oxidation state evolution from individual atoms to secondary particles. By performing nanoscale to microscale characterizations, distinct structural change pathways associated with intraparticle heterogeneous reactions are identified. The high level of oxygen defects formed throughout the particle by slow electrochemical activation triggers progressive phase transformation and the formation of nanovoids. Ultrafast lithium (de)intercalation leads to oxygen-distortion-dominated lattice displacement, transition metal ion dissolution and lithium site variation. These inhomogeneous and irreversible structural changes are responsible for the low initial Coulombic efficiency, and ongoing particle cracking and expansion in the subsequent cycles.</p>","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"58 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nonlinear Hall effect in an insulator","authors":"Cheng-Ping Zhang, K. T. Law","doi":"10.1038/s41565-024-01755-6","DOIUrl":"10.1038/s41565-024-01755-6","url":null,"abstract":"The third-order nonlinear Hall effect is observed in the quantum Hall states in graphene.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 10","pages":"1432-1433"},"PeriodicalIF":38.1,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142090262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"DNA nanoswitches pack an anti-cancer punch","authors":"Kun Zhou, Chenxiang Lin","doi":"10.1038/s41565-024-01749-4","DOIUrl":"https://doi.org/10.1038/s41565-024-01749-4","url":null,"abstract":"A DNA origami nanodevice presents its hidden death ligand pattern in the acidic tumour microenvironment to kill cancerous cells, opening opportunities for effective and safe cancer therapy.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"59 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142090276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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