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An octahedral metal oxide nanoparticle-based dual-signal sensing platform for simultaneous detection of histidine and lysine in human blood plasma and urine.
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-02-10 DOI: 10.1039/d4na00932k
Robina Akhtar, Asim Yaqub, Zia Ul Haq Khan, Ali Turab Jafry, Huma Ajab
{"title":"An octahedral metal oxide nanoparticle-based dual-signal sensing platform for simultaneous detection of histidine and lysine in human blood plasma and urine.","authors":"Robina Akhtar, Asim Yaqub, Zia Ul Haq Khan, Ali Turab Jafry, Huma Ajab","doi":"10.1039/d4na00932k","DOIUrl":"10.1039/d4na00932k","url":null,"abstract":"<p><p>Histidine and lysine serve as essential amino acids in physiological processes and biomarkers for specific diseases, requiring precise detection methods in a variety of samples. This study presents an affordable single colorimetric probe that employs nickel oxide nanoparticles (NiONPs) as an artificial enzyme to detect histidine and lysine, improving conventional analytical limitations. The characterization of NiONPs was executed using SEM-EDX, FE-SEM, FTIR and XRD. The NiONPs demonstrated peroxidase-like catalytic activity on the conversion of TMB to oxidized TMB (oxTMB) in the presence of H<sub>2</sub>O<sub>2</sub>, utilizing optimization parameters like pH value (3), TMB concentration (10 mM), H<sub>2</sub>O<sub>2</sub> concentration (60 mM), and incubation time (18 min). The study revealed that Ni and O atoms are present on the surface of NiONPs, allowing for specific interactions with essential amino acids and temporarily hindering the catalytic activity of oxidized TMB. The method exhibited a low limit of detection (LOD) of 0.07 μM (10-100 μM) for histidine and 1.1 μM (15-150 μM) for lysine with good stability. The proposed strategy was validated with urine and plasma samples, yielding favorable recoveries of 93.6-98.2% in urine and 90.5-96.0% in plasma for histidine and 91.2-94.8% in urine and 88.4-93.3% in plasma for lysine, supporting its selectivity, feasibility, and reliability for practical applications. In the future, this methodology will facilitate the integration of histidine and lysine detection into microfluidic systems using NiONPs as a colorimetric probe.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Light driven water oxidation on silica supported NiO-TiO2 heteronanocrystals yields hydrogen peroxide.
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-02-10 DOI: 10.1039/d4na00906a
Nurul Muttakin, Shelton J P Varapragasam, Rashed Mia, Mahfuz A Swadhen, Michael Odlyzko, James D Hoefelmeyer
{"title":"Light driven water oxidation on silica supported NiO-TiO<sub>2</sub> heteronanocrystals yields hydrogen peroxide.","authors":"Nurul Muttakin, Shelton J P Varapragasam, Rashed Mia, Mahfuz A Swadhen, Michael Odlyzko, James D Hoefelmeyer","doi":"10.1039/d4na00906a","DOIUrl":"10.1039/d4na00906a","url":null,"abstract":"<p><p>Decomposition of nickel nitrate hexahydrate in the presence of rod-shape anatase TiO<sub>2</sub> nanocrystals led to the formation of NiO-TiO<sub>2</sub> heteronanocrystals confirmed with powder X-ray diffraction and electron microscopy. The heteronanocrystals were supported on amorphous fumed silica to provide a heterogeneous photocatalyst material SiO<sub>2</sub>/NiO-TiO<sub>2</sub>. The aqueous suspension of the catalyst, under argon atmosphere, irradiated with a Xe arc lamp led to the formation of H<sub>2</sub>O<sub>2</sub> with trace gaseous product formation. We observed an initial rate of formation of H<sub>2</sub>O<sub>2</sub> of 1.8 μmol g<sup>-1</sup> min<sup>-1</sup> that decays toward a steady-state concentration of 52 μM. Addition of AgNO<sub>3</sub> to the aqueous suspension gave fast reduction of silver ion, and higher initial rates of formation and steady state concentrations of H<sub>2</sub>O<sub>2</sub>. We report the concentration dependence of water oxidation <i>versus</i> [AgNO<sub>3</sub>] with the fastest initial rate of formation of H<sub>2</sub>O<sub>2</sub> as 9.1 μmol g<sup>-1</sup> min<sup>-1</sup> and a steady-state concentration of 174 μM.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reversible doping and fine-tuning of the Dirac point position in the topological crystalline insulator Pb1-x Sn x Se via sputtering and annealing process.
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-02-10 DOI: 10.1039/d4na00821a
Artem Odobesko, Johannes Jung, Andrzej Szczerbakow, Jędrzej Korczak, Tomasz Story, Matthias Bode
{"title":"Reversible doping and fine-tuning of the Dirac point position in the topological crystalline insulator Pb<sub>1-<i>x</i></sub> Sn <sub><i>x</i></sub> Se <i>via</i> sputtering and annealing process.","authors":"Artem Odobesko, Johannes Jung, Andrzej Szczerbakow, Jędrzej Korczak, Tomasz Story, Matthias Bode","doi":"10.1039/d4na00821a","DOIUrl":"10.1039/d4na00821a","url":null,"abstract":"<p><p>In this study, we utilize scanning tunneling microscopy and spectroscopy to detail a sputter- and annealing methodology for preparing atomically clean Pb<sub>1-<i>x</i></sub> Sn <sub><i>x</i></sub> Se(001) surfaces. We examine the impact these processes have on the surface quality, the composition, and the electronic properties. Our findings demonstrate that annealing temperatures between 250 °C and 280 °C produce smooth surfaces while maintaining the topological properties of Pb<sub>1-<i>x</i></sub> Sn <sub><i>x</i></sub> Se. Fine control of the annealing temperature also allows for a reversible tuning of the doping level, enabling a positive or negative shift of the Dirac point energy with respect to the Fermi level. Our results highlight the effectiveness of these cleaning methods and demonstrate their potential for future research and applications in topological crystalline insulator materials.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High performance supercapacitors driven by the synergy of a redox-active electrolyte and core-nanoshell zeolitic imidazolate frameworks.
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-02-10 DOI: 10.1039/d4na00805g
Mansi, Vishal Shrivastav, Prashant Dubey, Aristides Bakandritsos, Shashank Sundriyal, Umesh K Tiwari, Akash Deep
{"title":"High performance supercapacitors driven by the synergy of a redox-active electrolyte and core-nanoshell zeolitic imidazolate frameworks.","authors":"Mansi, Vishal Shrivastav, Prashant Dubey, Aristides Bakandritsos, Shashank Sundriyal, Umesh K Tiwari, Akash Deep","doi":"10.1039/d4na00805g","DOIUrl":"10.1039/d4na00805g","url":null,"abstract":"<p><p>The selection of appropriate electrolytes plays a crucial role in improving the electrochemical performance of the supercapacitor electrode. The electrolyte helps to select an appropriate potential window of the device, which is directly related to its energy density. Also, the selection of an appropriate electrode material targets the specific capacitance. Therefore, in this work, we targeted an electrode material based on a ZIF-8@ZIF-67 (Z867) core-nanoshell structure and tested its performance in redox active electrolyte (RAE), <i>i.e.</i>, 0.2 M K<sub>3</sub>[Fe(CN)<sub>6</sub>] in 1 M Na<sub>2</sub>SO<sub>4</sub>. The synergy between the core-nanoshell electrode having ZIF-8 as a core and ZIF-67 as a nanoshell along with RAE further complements the redox active sites, resulting in the improved charge transport. Therefore, when the Z867 core-nanoshell electrode is tested in a three-electrode system, it outperforms pristine ZIF-8 and ZIF-67 electrode materials. The working electrode modified with the Z867 core-nanoshell showed a maximum specific capacitance of 496.4 F g<sup>-1</sup> at 4.5 A g<sup>-1</sup> current density with the RAE, which is much higher than that of the aqueous electrolyte. A Z867-modified working electrode was assembled as the positive and negative electrode in a symmetrical cell configuration to create a redox supercapacitor device for practical application. The constructed device displayed maximal energy and power densities of 49.6 W h kg<sup>-1</sup> and 3.2 kW kg<sup>-1</sup> respectively, along with a capacitance retention of 92% after 10 000 charge-discharge cycles. Hence, these studies confirm that using RAE can improve the electrochemical performance of electrodes to a greater extent than that of aqueous electrolyte-based supercapacitors.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direct chemical lithography writing on 2D materials by electron beam induced chemical reactions.
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-02-10 DOI: 10.1039/d5na00036j
Iryna Danylo, Lukáš Koláčný, Kristína Kissíková, Tomáš Hartman, Martina Pitínová, Jiří Šturala, Zdeněk Sofer, Martin Veselý
{"title":"Direct chemical lithography writing on 2D materials by electron beam induced chemical reactions.","authors":"Iryna Danylo, Lukáš Koláčný, Kristína Kissíková, Tomáš Hartman, Martina Pitínová, Jiří Šturala, Zdeněk Sofer, Martin Veselý","doi":"10.1039/d5na00036j","DOIUrl":"10.1039/d5na00036j","url":null,"abstract":"<p><p>Due to their high surface-to-volume ratio and native band gaps, two-dimensional (2D) materials are widely used as supports for metal nanoparticle (NP) catalysts. Various synthesis methods exist to prepare such materials, but controlling the amount, size, and distribution of the deposited NPs remains a challenge. Here, we investigate the use of electron beam lithography (EBL) for this purpose. A dual-beam focused ion beam-scanning electron microscope (FIB-SEM) was used to direct the deposition of platinum NPs (Pt NPs) onto 2D graphene oxide, functionalized with epoxy and hydroxyl (HUGO) or carboxyl (TOGO) groups, and black phosphorus (BP) sheets. According to NP size, the deposition was conducted for various exposure times and several types of particle distribution. EDS confirmed the required chemical composition of all of the prepared materials. SEM showed the amount and distribution of the supported NPs, and TEM confirmed their size. Raman spectroscopy revealed a strong bonding between the NPs and the support sheets according to the type of 2D support. These results suggest that EBL is a promising method for the target-controlled deposition of metal NPs of targeted amount, size, and spatial distribution onto 2D materials, which enables evaluating the specific influence of the NP-support interaction on enhanced catalytic activity.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Without a grain of salt: micropatterning clean MXene thin-film electronics.
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-02-07 DOI: 10.1039/d4na00983e
Bar Favelukis, Barak Ratzker, Rebeca Miyar, Jürgen Jopp, Alexander Upcher, Pini Shekhter, Nitzan Maman, Maxim Sokol
{"title":"Without a grain of salt: micropatterning clean MXene thin-film electronics.","authors":"Bar Favelukis, Barak Ratzker, Rebeca Miyar, Jürgen Jopp, Alexander Upcher, Pini Shekhter, Nitzan Maman, Maxim Sokol","doi":"10.1039/d4na00983e","DOIUrl":"10.1039/d4na00983e","url":null,"abstract":"<p><p>MXenes exhibit remarkable electrical, mechanical, and thermal properties, positioning them as strong candidates for high-performance electrodes and interconnects. Deposited 2D MXene thin-films suffer from a persistent issue of crystalline salt residues that originate from dissolved intercalation salts used for the exfoliation process during synthesis. These 3D salt by-products can cause issues during further nanofabrication processing and be detrimental to integrated device performance. This study introduces a three-step approach involving spin-coating deposition, HCl spin-cleaning, and lift-off. Rigorous morphological characterization of the patterned MXene was performed, confirming that the spin-cleaning step effectively removed all halide salt residues. Transparent sub-10 nm-thick MXene thin-film electrodes, down to a width of 5 μm with ∼1.5 μm resolution, were produced. The electrical properties were probed, showcasing exceptional conductivity (∼1350 S cm<sup>-1</sup> for a 50 μm-wide electrode) with high photosensitivity at the MXene-Si junction. The proposed method yields clean patterned MXene thin films, enabling easier integration of MXene or other 2D materials into future microelectronic devices.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
hBN/TiO2 water-based nanolubricants: a solution for stick-slip mitigation in tribological applications.
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-02-06 DOI: 10.1039/d4na01049c
Afshana Morshed, Fei Lin, Hui Wu, Zhao Xing, Sihai Jiao, Md Mahadi Hasan, Zhengyi Jiang
{"title":"hBN/TiO<sub>2</sub> water-based nanolubricants: a solution for stick-slip mitigation in tribological applications.","authors":"Afshana Morshed, Fei Lin, Hui Wu, Zhao Xing, Sihai Jiao, Md Mahadi Hasan, Zhengyi Jiang","doi":"10.1039/d4na01049c","DOIUrl":"10.1039/d4na01049c","url":null,"abstract":"<p><p>In this study, the stick-slip behaviour of synthesised water-based nanolubricants was investigated <i>via</i> an Rtec ball-on-disk tribometer. By varying the lubricating conditions, including the concentration of hBN/TiO<sub>2</sub> as nanoadditives, the tribological properties and lubrication mechanisms were analysed, especially the stick-slip phenomenon. Compared with dry and wet conditions, the hBN/TiO<sub>2</sub> nanolubricant presented better efficiency in mitigating stick-slip and achieving friction stability. The relationship between anti-stick-slip properties and lubrication assisted in the selection of high-performance water-based nanoadditives. At a concentration of 0.5 wt% hBN/TiO<sub>2</sub>, the nanolubricant achieved the lowest average coefficient of friction (COF) of up to 78% compared to that under dry conditions. Additionally, the 0.5 wt% hBN/TiO<sub>2</sub> nanolubricant showed an excellent anti-stick-slip effect, with the overall stick-slip phenomenon and threshold speed reduced by 77% and 72%, respectively, compared with those under dry conditions. Moreover, the findings indicate that the anti-stick-slip effect under wet conditions is superior to that under dry conditions. The mechanism of hBN/TiO<sub>2</sub> nanoadditives in inhibiting stick-slip behaviour involves trapping wear debris and forming uniform tribofilms. It can be predicted that an optimal concentration of hBN/TiO<sub>2</sub> (0.5 wt%) can eliminate the stick-slip phenomenon and effectively improve the friction state of the sliding interface.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11826335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cuprous iodide implanted in hot-water-soluble-starch coating of ferrite nanoparticles: efficient catalysts for on-water click synthesis of 1,2,3-triazoles.
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-02-06 DOI: 10.1039/d4na00883a
Seyyed Mohammad Rezapour Mousavi, Kurosh Rad-Moghadam
{"title":"Cuprous iodide implanted in hot-water-soluble-starch coating of ferrite nanoparticles: efficient catalysts for on-water click synthesis of 1,2,3-triazoles.","authors":"Seyyed Mohammad Rezapour Mousavi, Kurosh Rad-Moghadam","doi":"10.1039/d4na00883a","DOIUrl":"10.1039/d4na00883a","url":null,"abstract":"<p><p>Conglomerates of CuI nanoparticles combined with ferrous ferrite (FF) and cobalt ferrite (CF) nanoparticles were obtained using hot-water-soluble starch (HWSS) as a green adhesive possessing a strong complexing affinity for both the ferrites and CuI nanoparticles. Our findings indicate that the size of the CuI nanoparticles is closely related to the size of the ferrite nanoparticles, suggesting that the CuI nanoparticles grafted from the HWSS coating of the ferrite nanoparticles. The TEM image, size histograms derived from FE-SEM images and XRD patterns of the resulting composites revealed that the growth of CuI nanoparticles led to formation of conglomerates and not encapsulation of the ferrite nanoparticles. More interestingly, HWSS impacts oppositely on coercivities of the ferrites. The catalytic efficacy of the resulting nano-composites, CuI@HWSS@CF and CuI@HWSS@FF, in the one-pot synthesis of 1,2,3-triazoles through the click reaction of alkyl halides, sodium azide, and phenylacetylene \"on water\" is described. The use of a biocompatible nano-catalyst, easy catalyst recycling and high yields of the triazoles within short reaction times are the significant advantages of the synthetic method presented here.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep co-deposition of polydopamine in PVDF hydrogel to enhance photothermal evaporation efficiency.
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-02-05 DOI: 10.1039/d4na00963k
Yu Ma, Lan Yang, Shangdi Wu, Liran Xu, Hua Huang
{"title":"Deep co-deposition of polydopamine in PVDF hydrogel to enhance photothermal evaporation efficiency.","authors":"Yu Ma, Lan Yang, Shangdi Wu, Liran Xu, Hua Huang","doi":"10.1039/d4na00963k","DOIUrl":"10.1039/d4na00963k","url":null,"abstract":"<p><p>Polydopamine (PDA) is a widely utilized photothermal conversion material recognized for its ease of synthesis and environmental friendliness. However, its relatively weak light absorption capabilities lead to lower photothermal efficiency, restricting its application in solar steam generation (STG) processes. To effectively enhance light absorption, this study introduces a deep co-deposition method for the microstructural design of STG membranes. Unlike traditional surface co-deposition methods, which coat a layer of PDA on the membrane surface, the deep co-deposition method allows for the incorporation of PDA within the internal nanohydrogel structural units of the membrane. This approach significantly increases the PDA loading, resulting in a marked enhancement of light absorption capabilities. In the near-infrared region (800-2500 nm), where the light absorption of PDA is relatively weak, the absorbance improved from 70.18% (surface co-deposition) to 88.20% (deep co-deposition). While PDA has been extensively studied across various fields, its application as a structural and functional additive in hydrogels remains limited, particularly in comparison to the rapid advancements in PDA-based surface-engineered hydrogels. Thus, this study may provide valuable insights for related research areas.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11808334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Docetaxel-conjugated bile acid-derived nanomicelles can inhibit tumour progression with reduced toxicity.
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-02-04 DOI: 10.1039/d4na00715h
Devashish Mehta, Chhavi Dua, Ruchira Chakraborty, Poonam Yadav, Ujjaini Dasgupta, Avinash Bajaj
{"title":"Docetaxel-conjugated bile acid-derived nanomicelles can inhibit tumour progression with reduced toxicity.","authors":"Devashish Mehta, Chhavi Dua, Ruchira Chakraborty, Poonam Yadav, Ujjaini Dasgupta, Avinash Bajaj","doi":"10.1039/d4na00715h","DOIUrl":"10.1039/d4na00715h","url":null,"abstract":"<p><p>Docetaxel (DTX) is a highly effective chemotherapy drug commonly employed in the management of multiple cancers, such as breast, lung, and prostate cancer. However, its clinical usage is significantly hampered by its limited solubility, which limits its bioavailability, and its considerable toxic effects like neutropenia, neuropathy, and hypersensitive reactions. These limitations necessitate the development of innovative formulations to boost the therapeutic index of DTX. In this study, we aimed to enhance the tolerability and reduce the toxic effects of DTX by developing a novel hybrid scaffold (PIP-LCA-DTX), where we conjugated DTX to piperidine-derived lithocholic acid. This hybrid scaffold integrates the beneficial properties of bile acid-based drug conjugates and cationic amphiphiles to form stable and effective drug delivery systems. Our research demonstrates that PIP-LCA-DTX exhibits similar anticancer properties to DTX when tested against murine colon cancer (CT26) and melanoma (B16-F10) cell lines, indicating that the hybrid retains the therapeutic efficacy of the original drug. Our findings revealed that PIP-LCA-DTX forms stable nanomicelles (DTX-NMs) with an average hydrodynamic diameter of <150 nm and provides a promising delivery system by enhancing the solubility and stability of DTX. DTX-NMs showed significantly better tolerability and enhanced therapeutic efficacy (survival) compared to DTX alone. This improved tolerability, combined with the maintained therapeutic efficacy of DTX-NMs against murine cancer models, suggests that this hybrid scaffold could offer a more viable and safer option for cancer treatment.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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