Nanoscale Advances最新文献

{"title":"Correction: Development and in vitro and ex vivo characterization of a twin nanoparticulate system to enhance ocular absorption and prolong retention of dexamethasone in the eye: from lab to pilot scale optimization","authors":"Muhammad Sarfraz, Gautam Behl, Sweta Rani, Niall O'Reilly, Peter McLoughlin, Orla O'Donovan, Alison L. Reynolds, John Lynch and Laurence Fitzhenry","doi":"10.1039/D5NA90032H","DOIUrl":"https://doi.org/10.1039/D5NA90032H","url":null,"abstract":"<p >Correction for ‘Development and <em>in vitro</em> and <em>ex vivo</em> characterization of a twin nanoparticulate system to enhance ocular absorption and prolong retention of dexamethasone in the eye: from lab to pilot scale optimization’ by Muhammad Sarfraz <em>et al.</em>, <em>Nanoscale Adv.</em>, 2025, https://doi.org/10.1039/d4na01086h.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 10","pages":" 3143-3143"},"PeriodicalIF":4.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/na/d5na90032h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization, and evaluation of low molecular weight poly(β-amino ester) nanocarriers for enhanced T cell transfection and gene delivery in cancer immunotherapy.","authors":"Alireza Gharatape, Ali Sayadmanesh, Hamid Sadeghi-Abandansari, Hossein Ghanbari, Mohsen Basiri, Reza Faridi-Majidi","doi":"10.1039/d5na00169b","DOIUrl":"https://doi.org/10.1039/d5na00169b","url":null,"abstract":"<p><p>Cancer immunotherapy represents a revolutionary approach in cancer treatment by leveraging the body's immune system to target and eliminate cancer cells. An emerging strategy within this field is gene delivery, which can enhance the efficacy of immune cells. Nanocarrier-based gene delivery methods have gained prominence due to their ability to protect and transport genetic material into cells efficiently. Polymeric nanocarriers, in particular, offer significant advantages, such as customizable physical and chemical properties, biocompatibility, and the potential for targeted delivery. Among polymeric nanocarriers, poly(β-amino ester) (PBAE) polymers are notable for their biodegradability, low cytotoxicity, and high gene transfection efficiency. This study investigates the synthesis and characterization of low molecular weight PBAE nanocarriers, assessing their potential in gene delivery applications for Jurkat and primary T cells-both crucial in cancer immunotherapy. Our research involved synthesizing PBAE polymer and creating nanocarriers at various DNA-to-polymer ratios. We characterized these nanocarriers in terms of size, zeta potential, and encapsulation efficiency. Confocal microscopy and flow cytometry were utilized to evaluate cellular uptake and transfection efficiency. The results demonstrated appropriate transfection efficiency and significant gene expression in both hard-to-transfect cell types (jurkat up to 37% and primary T cell 5%), with optimized DNA-to-polymer ratios showing minimal cytotoxicity. This study highlights the potential of PBAE nanocarriers in enhancing gene delivery for cancer immunotherapy. By effectively transfecting T cells, these nanocarriers could improve the therapeutic outcomes of immunotherapy, offering a promising pathway for developing more effective cancer treatments.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The electronic properties of functionalized MXene M2XT2 (M = Ti, Zr, Sc; X = C; T = O, F) nanoribbon/striped borophene nanoribbon heterojunctions","authors":"Mahdi Shirazinia and Edris Faizabadi","doi":"10.1039/D4NA00629A","DOIUrl":"10.1039/D4NA00629A","url":null,"abstract":"<p >The van der Waals heterojunctions and heterostructures developed from diverse materials demonstrate unparalleled potential by combining the favorable properties of their structural layers. In this investigation, we initially showcase the findings and evaluations derived from Density Functional Theory (DFT) of selected functionalized MXene nanoribbons (Ti<small>₂</small>CO<small>₂</small>, Zr<small>₂</small>CO<small>₂</small>, and Sc<small>₂</small>CF<small>₂</small>), along with four types of striped borophene nanoribbons. Nanoribbons come in two forms (armchair and zigzag) and have a variety of widths. Except for 9-, 12-, and 15-MZNRs, there are no band gaps on MXene nanoribbons arranged in a zigzag pattern. Contrastingly, band gaps emerge in MXene nanoribbons with armchair-shaped edges. It is also discovered that every selected SBNR is metallic in nature. Lastly, we carried out a computational analysis of the electronic characteristics of the MNR/SBNR heterojunctions. The significant thermodynamic stability of MNR/SBNR heterojunctions is suggested by the small lattice mismatch in the periodic direction and the negative formation energies. Our research demonstrates that all heterojunction samples exhibit metallic behavior. Additionally, we observed significant changes in total magnetization when applying electric fields of different directions and amplitudes to the heterojunction samples. These findings present promising avenues for enhancing and controlling multiferroics or electrically controllable antiferromagnets, as well as advancing spintronic devices. Moreover, they hold potential for memory devices and sensors.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 11","pages":" 3546-3557"},"PeriodicalIF":4.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atomic layer deposition of Ru in nanoTSV with high coverage and low resistivity.","authors":"Zhao Chen, Feifeng Huang, Biao Wang, Qiancheng Wang, Hongbin Chen, Qiu Shao, Bo Feng, Ming Ji, Huigao Duan","doi":"10.1039/d5na00051c","DOIUrl":"https://doi.org/10.1039/d5na00051c","url":null,"abstract":"<p><p>With the advancement of Moore's Law, the metal linewidth has gradually reduced and Cu interconnection has lost its advantages. This paper explores the advantage of ruthenium (Ru) as a next-generation interconnection material. An Ru film with a resistivity of 15 μΩ cm and roughness of 0.8 nm was fabricated <i>via</i> atomic layer deposition (ALD) using the metal-organic precursor (bis(ethylcyclopentadienyl)ruthenium [Ru(EtCp)₂]) and oxygen as the reactant. Excellent step coverage and filling in nanoTSV arrays with a critical dimension (CD) of 30 nm and an aspect ratio (AR) of approximately 15 demonstrate that the reported process is highly promising for fabricating Ru as a replacement for Cu interconnects in advanced integrated circuits (ICs).</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphology and property tuning in ZnO–Ni hybrid metamaterials in vertically aligned nanocomposite (VAN) form†","authors":"Nirali A. Bhatt, Lizabeth Quigley, Shiyu Zhou, Anirutha Gnanasabai, Abhijeet Choudhury, Yizhi Zhang, Jianan Shen, Juanjuan Lu, Aleem Siddiqui, Raktim Sarma and Haiyan Wang","doi":"10.1039/D5NA00207A","DOIUrl":"10.1039/D5NA00207A","url":null,"abstract":"<p >ZnO thin films have attracted significant interest in the past decades owing to their unique wide band gap properties, piezoelectric properties, non-linearity and plasmonic properties. Recent efforts have been made in coupling ZnO with secondary phases to enhance its functionalities, such as Au–ZnO nanocomposite thin films with tunable optical and plasmonic properties. In this work, magnetic nanostructures of Ni are incorporated in ZnO thin films in a vertically aligned nanocomposite (VAN) form to couple magnetic and plasmonic response in a complex hybrid metamaterial system. Nickel (Ni) is of interest due to its ferromagnetic and plasmonic properties along with gold (Au) which is also plasmonic. Therefore, two approaches, namely, tuning of the deposition pressure and use of a ZnO–Au seeding layer have been attempted to achieve unique Ni nanostructures in addition to tuning of the microstructure. Together, both approaches demonstrate a range of microstructures such as core–shell, nanodisk, nanocup, and nanocube-like morphologies not previously attempted. Additionally, there is effective tuning of properties. Specifically, the seeding layer thickness causes hyperbolic behavior as well as redshift in the surface plasmon resonance (SPR) wavelength. The addition of the ZnO–Au seeding layer directly influences the optical properties. Plus, regardless of the different approaches, the films demonstrate magnetic anisotropy based on the composition and microstructure of the film which impacted the saturation magnetization and coercivity. This study demonstrates the potential of ZnO-based complex hybrid metamaterials with coupled electro-magneto-optical properties for integrated photonic devices.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 11","pages":" 3528-3538"},"PeriodicalIF":4.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial and photocatalytic activities of fruit-extract-mediated synthesized ZnO nanoparticles†","authors":"Ngoan Thi Thao Nguyen, Anh Nguyen Quynh Phan, Thuan Van Tran and Thuy Thi Thanh Nguyen","doi":"10.1039/D5NA00211G","DOIUrl":"10.1039/D5NA00211G","url":null,"abstract":"<p >ZnO nanoparticles were produced using <em>Morinda citrifolia</em> fruit extract and evaluated for their performance in the removal of Congo red (CR) dye under visible light, as well as their antibacterial activity against different pathogenic strains. The ZnO photocatalyst was characterized according to crystallinity, surface elements and morphology. Various factors related to photocatalytic activity, namely contact time, photocatalyst dosage, initial CR concentration, and pH, were investigated. Under optimal conditions, a moderate ZnO loading achieved a high CR degradation efficiency of 95.23% within 60 min of light irradiation, as determined using response surface methodology (RSM) coupled with face-centered design (CCF). Additionally, a scavenger study confirmed that superoxide radicals (˙O<small>₂</small><small>⁻</small>) and holes (h<small>⁺</small>) were major reactive species in the photodegradation of CR. Furthermore, the antibacterial activity was remarkable, with the highest inhibition zone measuring 20.7 mm against <em>Salmonella typhimurium</em>. This study provides a promising approach for developing highly efficient photocatalysts with strong adsorption capabilities whilst also broadening their application as antibacterial agents.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 11","pages":" 3514-3527"},"PeriodicalIF":4.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of the synergism between eggshells and copper in nanotechnology.","authors":"Priyanka Sharma, Mainak Ganguly, Ankita Doi","doi":"10.1039/d5na00400d","DOIUrl":"10.1039/d5na00400d","url":null,"abstract":"<p><p>Eggshells, the non-edible part of an egg, have immense uses in nanotechnology. Copper being an inexpensive metal has versatile applications in nanotechnology. However, its susceptibility to oxidation limits its practical applications. Eggshells are an efficient candidate to synthesize cap copper nanoparticles and copper nanoclusters, which are used in various arenas (dye degradation, antibacterial activity, nitrophenol adsorption, copper adsorption, and sensing). Reports on the edible part of an egg for passivating copper nanoparticles are rare. Usually, chicken eggshells are mostly used in this regard. Moreover, eggshells can be used for the adsorption of ionic copper. Thus, the synergism between eggshells and copper is a very pivotal aspect. The use of biological waste in association with copper in various applications may open a new pathway towards the circular economy. This review article summarizes applications that evolved from copper-eggshell synergism.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metasurface-enabled small-satellite polarisation imaging†","authors":"Sarah E. Dean, Josephine Munro, Neuton Li, Robert Sharp, Dragomir N. Neshev and Andrey A. Sukhorukov","doi":"10.1039/D5NA00298B","DOIUrl":"10.1039/D5NA00298B","url":null,"abstract":"<p >Polarisation imaging is used to distinguish objects and surface characteristics that are otherwise not visible with black-and-white or colour imaging. Full-Stokes polarisation imaging allows complex image processing like water glint filtering, which is particularly useful for remote Earth observations. The relatively low cost of small-satellites makes their use in remote sensing more accessible. However, their size and weight limitations cannot accommodate the bulky conventional optics needed for full-Stokes polarisation imaging. We present the modelling of an ultra-thin topology-optimised diffractive metasurface that encodes polarisation states in five different diffraction orders. Positioning the metasurface in a telescope's pupil plane allows the diffraction orders to be imaged onto a single detector, resulting in the capability to perform single-shot full-Stokes polarisation imaging of the Earth's surface. The five rectangular image swaths are designed to use the full width of the camera, and then each successive frame can be stitched together as the satellite moves over the Earth's surface, restoring the full field of view achievable with any chosen camera without comprising the on-ground resolution. Each set of four out of the five orders enables the reconstruction of the full polarisation state, and their simultaneous reconstructions allow for error monitoring. The lightweight design and compact footprint of the polarisation imaging optical system achievable with a metasurface is a novel approach to increase the functionality of small satellites while working within their weight and volume constraints.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 11","pages":" 3579-3587"},"PeriodicalIF":4.6,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuning the phase separation of cellulose nanocrystals with hydrolysis times: influence of effective dimensions†","authors":"Shiyao Hong, Ashley Bean, Yuan Fang, Nathalie Lavoine and Lucian Lucia","doi":"10.1039/D5NA00069F","DOIUrl":"10.1039/D5NA00069F","url":null,"abstract":"<p >This study attempts to quantify a relatively unexplored and very important subject: cellulose nanocrystal (CNC) bundles and their effective dimensions on phase separation and subsequent chiral resolution in CNC suspensions. Currently, there is little data discussing how effective bundle dimensions affect the onset of chiral nematic phase formation despite the fact that theory and experimental data indicate they are important factors. The effect of the extent of hydrolysis on the phase behavior of CNC suspensions was analyzed by correlating it with the critical weight concentration (<em>w</em><small>₀</small>), which is the CNC weight corresponding to the onset of the chiral nematic phase. From Onsager theory and its extension, <em>w</em><small>₀</small> is primarily a function of CNC size while surface charge exerts a non-negligible effect. CNCs were produced from never-dried bleached softwood pulp under varying acid hydrolysis times to systematically alter sizes and surface charges. Concentration-dependent phase diagrams were mapped to ascertain the <em>w</em><small>₀</small> of the produced suspensions. The data revealed a clear decrease in <em>w</em><small>₀</small> when the hydrolysis time increased from 25 to 90 minutes, despite similar individual CNC size and increasing surface charges. This latter discovery following shape and size distribution indicated an increased area-equivalent (AE) diameter from extended hydrolysis, suggesting particle aggregation/bundling. This result was corroborated by elevated particle surface charges from enhanced lateral adherence between CNCs. In contrast to our findings that higher surface charge reduces the effective diameter, the observed decrease in <em>w</em><small>₀</small> suggests that an earlier onset of the anisotropic phase is driven by CNC bundles, which were more prevalent in samples with elevated surface charge. These observations indicate that CNC bundles play a significant role in promoting the anisotropic phase, counteracting the effect of surface charge on <em>w</em><small>₀</small>. This work therefore provides invaluable insights into the complex interplay of CNC surface charge, shape, and size by shedding light on the importance of hydrolysis time on particle aggregation and phase behavior in CNC suspensions.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 11","pages":" 3476-3484"},"PeriodicalIF":4.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel fullerene-lysine derivative with noticeable ROS scavenging capabilities for improving type 2 diabetes mellitus","authors":"Jiaqi Weng, Wei Guo, Jie Liu, Kollie Larwubah, Jianjun Guo, Yanrong Jia and Meilan Yu","doi":"10.1039/D4NA01081G","DOIUrl":"10.1039/D4NA01081G","url":null,"abstract":"<p >As some of the most promising candidates available, fullerene-derived bioactive agents have been explored as new drugs with high efficacy and safety for biomedical applications. In this study, a fullerene-lysine derivative (C<small>₆₀</small>-Lys) was synthesized successfully and proved to be good at treating type 2 diabetes mellitus (T2DM). C<small>₆₀</small>-Lys could alleviate oxidative stress both in streptozotocin (STZ)-induced MIN6 cells and in STZ-induced T2DM mice subjected to a high-fat diet, and it significantly normalized glucose uptake and reduced blood glucose. In addition, C<small>₆₀</small>-Lys can alleviate insulin resistance, hyperinsulinemia and lipid levels in T2DM mice. It was further confirmed that C<small>₆₀</small>-Lys could alleviate oxidative stress by increasing the activities of antioxidant enzymes and stabilizing the mitochondrial membrane potential (MMP) of pancreatic β-cells to reduce the overproduction of ROS. The results provide compelling evidence that C<small>₆₀</small>-Lys possesses promising applications for T2DM treatment.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 11","pages":" 3462-3475"},"PeriodicalIF":4.6,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}