Nanoscale Advances最新文献

{"title":"Fn14-targeting, NIR-II responsive nanomaterials for enhanced radiotherapy against glioblastomas.","authors":"Wei Fu, Qing Liang, Yuxi Ma, Shiqiong Lei, Ruiqi Li, Xin Zheng, Lian Chen, Jiayuan Chen, Xing Cai, Xiaofang Dai, Hongwei Duan, Wenshan He, Jinghua Ren","doi":"10.1039/d4na00788c","DOIUrl":"10.1039/d4na00788c","url":null,"abstract":"<p><p>Radiotherapy is a common treatment option for patients with glioblastoma multiforme. However, tumor heterogeneity causes varying responses to radiation among different tumor subpopulations. Cancer cells that endure radiotherapy exhibit radioresistance, resulting in the ineffectiveness of radiation therapy and eventual tumor relapse. In this study, we discovered that the fibroblast growth factor-inducible 14 (Fn14)-positive tumor cells were enriched in tumor residual foci after radiation, ultimately leading to treatment failure. Fn14-expressing glioma cells survived ionizing radiation through preferential activation of DNA damage checkpoint response. We have thus engineered an Fn14-targeting and NIR-II responsive plasmonic gold nanosystem named Fn14-AuNPs, which can precisely internalize into Fn14-overexpressed glioma cells and have an excellent BBB-crossing capability. As gold nanoparticles, by inhibition of DNA repair processes and induction of G₂/M cells cycle arrest, Fn14-AuNPs nanoparticles improved the radiosensitivity of tumor cells. Meanwhile, Fn14-AuNPs induced localized heat under NIR-II photoirradiation, thus impeding RT-induced DNA damage checkpoint response. This versatile nanosensitizer, combined with NIR-II laser photoirradiation, can eradicate radioresistant subpopulations of glioblastoma and improve the therapeutic effect of radiotherapy. This finding presents an effective radiosensitization strategy by targeting radioresistant subpopulations, which can efficiently overcome the constraints imposed in clinical radiotherapy and offer a hopeful avenue to enhance the treatment effectivity of radiotherapy in glioblastoma.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green procedures for synthesizing potential <i>h</i>NMDA receptor allosteric modulators through reduction and one-pot reductive acetylation of nitro(hetero)arenes using a superparamagnetic Fe₃O₄@APTMS@Cp₂ZrCl _{<i>x</i> (<i>x</i> = 0, 1, 2)} nanocatalyst.","authors":"Hossein Mousavi, Behzad Zeynizadeh, Farhad Sepehraddin","doi":"10.1039/d4na00882k","DOIUrl":"10.1039/d4na00882k","url":null,"abstract":"<p><p>The conversion of nitro(hetero)arenes to corresponding (hetero)aryl amines and other practical organic compounds plays a crucial role in various sciences, especially environmental remediation and public health. In the current research work, diverse green and efficient strategies for the convenient reduction (hydrogenation) and one-pot two-step reductive acetylation of nitro(hetero)arenes using a core-shell-type mesoporous zirconocene-containing magnetically recoverable nanocomposite (<i>viz.</i> Fe₃O₄@APTMS@Cp₂ZrCl _{<i>x</i> (<i>x</i> = 0, 1, 2)}) as a powerful nanocatalytic system have been developed. In the presented organic transformations, the superparamagnetic Fe₃O₄@APTMS@Cp₂ZrCl _{<i>x</i> (<i>x</i> = 0, 1, 2)} nanocomposite exhibited satisfactory turnover numbers (TONs) and turnover frequencies (TOFs), along with acceptable reusability. On the other hand, we investigated the potential biological effect of the synthesized (hetero)aryl amines and <i>N</i>-(hetero)aryl acetamides against the transmembrane domain (TMD) of the human <i>N</i>-methyl-d-aspartate (<i>h</i>NMDA) receptor based on molecular docking studies. Furthermore, the drug-likeness properties of our hit compound (<i>viz. N</i>-(3-(1-hydroxyethyl)phenyl)acetamide) have been scrutinized by <i>in silico</i> ADMET analyses.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transition in morphology and properties in bottom-up HPHT nanodiamonds synthesized from chloroadamantane.","authors":"Stepan Stehlik, Petr Belsky, Tomas Kovarik, Zuzana Nemeckova, Jiri Henych, Egor Ukraintsev, Ales Vlk, Martin Ledinsky, Evgeny Ekimov","doi":"10.1039/d4na00802b","DOIUrl":"https://doi.org/10.1039/d4na00802b","url":null,"abstract":"<p><p>Direct bottom-up high pressure high temperature (BU_HPHT) synthesis of nanodiamonds (NDs) from organic precursors excels in the ability to control the size of the resulting BU_HPHT NDs <i>via</i> the temperature of the synthesis. Here we investigated size-dependent thermal, colloidal, and structural properties of the BU_HPHT NDs and focused on the transition in morphology and properties occurring at around 900 °C (≈2 nm). Using transmission electron microscopy, small angle X-ray scattering and atomic force microscopy we show that the sub-900 °C samples (<2 nm NDs) do not have nanoparticle character but 2D platelet morphology with sub-nm unit thickness. Correspondingly, sub-900 °C samples (<2 nm NDs) have a negative zeta potential and hydrophobic character and should be considered as a form of a molecular diamond. The above-900C (>2 nm NDs) samples have nanocrystalline character, positive zeta potential and are dispersible in water similarly to other types of hydrogenated NDs. By <i>in situ</i> Raman spectroscopy experiments, we show that the transition is also related to the structural instability of the oxidized sub-2 nm BU_HPHT NDs.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomagnetic nickel complex based on salicylamide and l-proline ligands as an efficient heterogeneous catalyst for synthesis of tetrazoles.","authors":"Chou-Yi Hsu, Ghusoon Faidhi Hameed, Irfan Ahmad, Abhinav Kumar, Subbulakshmi Ganesan, Aman Shankhyan, S Sunitha, Rajashree Panigrahi","doi":"10.1039/d5na00168d","DOIUrl":"10.1039/d5na00168d","url":null,"abstract":"<p><p>A novel salicylamide-l-proline-nickel(ii) complex, supported on magnetic iron oxide [Fe₃O₄@salicylamide-l-proline-Ni(ii)], was synthesized through a three-step procedure. This included the functionalization of Fe₃O₄ with amine groups using glycine as a linker, followed by direct amidation of salicylic acid and its subsequent coordination with Ni(ii) and l-proline as a co-ligand to form the nanomagnetic Ni(ii) complex. The resulting catalyst was comprehensively characterized by several techniques. The catalyst exhibited outstanding catalytic performance in the homoselective synthesis of 5-substituted-1<i>H</i>-tetrazoles from benzonitriles. Notably, it demonstrated excellent recyclability, maintaining high efficiency over eight reaction cycles. The use of a low-cost linker, ligand, and complex catalyst, combined with easy magnetic separation, minimal leaching, and scalability, renders this approach both environmentally sustainable and economically advantageous compared to traditional Ni-based methods.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fe₂O₃-rice straw carbon dot composite for simultaneous electrochemical detection of dopamine and salbutamol.","authors":"Nguyen Van Hop, Nguyen Le My Linh, Vo Chau Ngoc Anh, Do Mai Nguyen, Tran Thanh Tam Toan","doi":"10.1039/d5na00065c","DOIUrl":"10.1039/d5na00065c","url":null,"abstract":"<p><p>A novel electrochemical sensor was developed using a composite of iron oxide (Fe₂O₃) and rice straw-based carbon dots (RSCD) for the simultaneous detection of dopamine (DPM) and salbutamol (SBT). By modifying a glassy carbon electrode (GCE) with the synthesized composite, the sensor achieved detection limits of 0.02 μM for DPM and 0.03 μM for SBT, with a linear range extending from 0.1 to 92 μM. Differential pulse voltammetry (DPV) demonstrated the sensor's enhanced sensitivity, selectivity, and resolution of overlapping oxidation peaks, overcoming key limitations of existing methods. Practical applications in neurotransmitter monitoring and food safety were validated using actual samples, highlighting the sensor's accuracy and reliability. This study introduces a scalable and cost-effective solution for electrochemical sensing with significant potential for broader societal impact.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897740/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microfluidic generation of nanoparticles using standing wave induced ultrasonic spray drying.","authors":"Holger Bolze, Keiran Mc Carogher, Simon Kuhn","doi":"10.1039/d4na01012d","DOIUrl":"https://doi.org/10.1039/d4na01012d","url":null,"abstract":"<p><p>Spray drying is a well-established process for generating particles for various applications, including pharmaceuticals. In this process, atomization plays a crucial role by defining the size of the droplets and, consequently, particle size. While ultrasound is commonly used to enhance atomization by reducing droplet size, a novel approach has been introduced that utilizes plug flow to generate plugs resonating with an applied ultrasound frequency, triggering surface atomization. This study investigates the applicability of this method for microfluidic atomization and spray drying, particular for pharmaceutical carrier particles. The generated droplets exhibit a size of 7.24 μm and a PDI of 0.18, indicating a monodisperse distribution. The droplets are produced in discrete burst events, enabling an energy-efficient pulsed process with an applied power of less than 1 W. This approach successfully generates lipid nanoparticles with an average size of 140 nm, underscoring its potential for nanoparticle production.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexible nanoimprinted substrate integrating piezoelectric potential and photonic-plasmonic resonances†","authors":"Aeshah F. Alotaibi, Rongcheng Gan, Eni Kume, Dominik Duleba, Ahmed Alanazi, Allan Finlay, Robert P. Johnson and James H. Rice","doi":"10.1039/D4NA00942H","DOIUrl":"10.1039/D4NA00942H","url":null,"abstract":"<p >Flexible substrates for sensing provide adaptable, lightweight, and highly sensitive platforms for detecting different substances. The flexibility of these substrates allows for seamless integration with complex shapes and dynamic surfaces, enabling monitoring in challenging conditions using methods such as surface-enhanced Raman spectroscopy (SERS). Here we outline a flexible metamaterial array sensor formed from plasmonic silver-coated nanoimprinted piezoelectric polyvinylidene fluoride film. We show that nanoscale array features can be prepared on the surface of the piezoelectric film using a facile nanoimprinting procedure. These nanoimprinted features act as polarization channels that enable plasmonic resonances, enhancing the SERS signal strength and improving reproducibility. We combine this effect with the inherent piezoelectric properties of polyvinylidene fluoride to further enhance the Raman signal strength upon mechanical deformation. Our results demonstrate a significant enhancement of the SERS signal when probed at a wavelength of 532 nm, achieving over an order of magnitude increase in signal strength for a range of analytes. This lightweight and flexible SERS substrate holds significant potential for applications in medical diagnostics, environmental monitoring, and trace detection, offering a highly sensitive and reproducible analytical platform.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 8","pages":" 2360-2367"},"PeriodicalIF":4.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chiral induction in the crystallization of KIO₃ and LiIO₃: the role of amino acids in controlling the chirality of inorganic crystals.","authors":"Matan Oliel, Yitzhak Mastai","doi":"10.1039/d4na01006j","DOIUrl":"10.1039/d4na01006j","url":null,"abstract":"<p><p>Chiral induction in crystals has attracted significant attention due to its implications for developing chiral materials and understanding mechanisms of symmetry-breaking enantioselective crystallization of naturally occurring chiral minerals. Despite its potential use in chiral discrimination, this area remains largely unexplored. Here, we investigate chiral induction during crystallization of naturally occurring chiral KIO₃ and LiIO₃ minerals using arginine and alanine as chiral inducers. The chiral nature of the crystallization and the effect of the chiral inducers were examined using circular dichroism, polarimetry, and low-frequency Raman spectroscopy. The impact of chiral molecules on the rate and final crystal structure was studied by electron microscopy including SEM and TEM. We demonstrate that it is possible to control the chirality with chiral exogenous molecules, mainly amino acids. Understanding chiral induction in crystal growth may open avenues for controlled assembly of chiral materials and development of novel functional materials with unique properties.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in RNAi-based nanoformulations: revolutionizing crop protection and stress tolerance in agriculture","authors":"Shivangi Mathur, Ambika Chaturvedi and Rajiv Ranjan","doi":"10.1039/D5NA00044K","DOIUrl":"10.1039/D5NA00044K","url":null,"abstract":"<p >Nucleic acid-based therapeutics have the ability to tackle a wide range of diseases and stress tolerance that present significant obstacles for conventional approaches in agriculture. RNA-based medicines have become a promising approach, using nanoformulation treatments to specifically target certain diseases. Nanoformulations offer numerous benefits in comparison to alternative treatment methods, such as precise administration, minimal toxicity, and medication loading compatibility due to their bioactivity. There are a variety of nanoformulations available today, such as liposomes, polymeric nanoparticles (NPs), magnetic NPs, nanogels, and solid lipid nanoparticles (SLNs). RNA-based therapy employs intracellular gene nanoparticles containing messenger RNA (mRNA), which play an important role in stress management and pest as well as disease control. The adoption of mRNA-based technology paves the way for future technological progress. This review focuses on elucidating the process underlying the development of RNA interference (RNAi) and the diverse array of nanocarriers employed for the transportation of RNAi. Currently, this technique is being employed in the field of crop protection to combat diseases, pests, and environmental stress. The article highlights the benefits of RNAi mediated nanoformulations and discusses the significant obstacles that must be overcome to improve the viability of this technology for future applications.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 7","pages":" 1768-1783"},"PeriodicalIF":4.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mangrove pneumatophores as biocatalysts for the fabrication of silver nanoparticles and their potential applications against biofilm formation and hepatic carcinoma.","authors":"Debasis Nayak, Awdhesh Kumar Mishra, Kunal Biswas, Asmita Sen, Chandana Malakar, Jibanjyoti Panda, Neelam Amit Kungwani, Sarvesh Rustagi, Bibhu Prasad Panda, Yugal Kishore Mohanta","doi":"10.1039/d4na00722k","DOIUrl":"10.1039/d4na00722k","url":null,"abstract":"<p><p>The current study demonstrates the biogenic synthesis of silver nanoparticles using the pneumatophores of <i>Acanthus ilicifolius</i> (AiP-AgNPs), which is cost-effective and biocompatible. <i>A. ilicifolius</i> possesses remarkable features to endure the harshest conditions for its entire life cycle and generates secondary metabolites for its sustainability in hostile mangrove ecosystems. The presence of a prominent UV-visible absorption band at 420 nm supported the distinct color change inference for the synthesized AiP-AgNPs. The size of the synthesized AiP-AgNPs was determined to be ∼15 nm through field emission-scanning electron microscopy (FE-SEM), transmission electron microscopy (cryo-TEM), and atomic force microscopy (AFM). The presence of secondary metabolites such as 2-bromo-1,1-dichloroethene, hemin and <i>N</i>-(sulfanylacetyl)-l-seryl-l-argininamide was indicated by prominent peaks in liquid chromatography, suggesting their probable roles in the synthesis of AgNPs. The synthesized AiP-AgNPs demonstrated a distinct zone of inhibition against <i>Pseudomonas aeruginosa</i> (15.33 mm), <i>Vibrio cholerae</i> (9.83 mm), and <i>Bacillus subtilis</i> (12 mm). They also exhibited concentration-dependent antioxidant activity in DPPH, nitric oxide, and hydrogen peroxide scavenging assays. The anticancer potential of the synthesized AiP-AgNPs against HepG2 hepatocarcinoma cells determined through MTT colorimetric assay and flow cytometry revealed their dose-dependent cytotoxicity with the occurrence of the sub-G₀ phase (25.6%). Subsequent analysis using fluorescence microscopy, DNA damage, comet assay, and migration assay indicated that AiP-AgNPs hold significant potential and the ability to serve as a therapeutic candidate to pave the way for further in-depth investigations for pre-clinical and clinical research purposes.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}