Nanoscale Advances最新文献

{"title":"A rapid one-step synthesis of silver and copper coordinated chlorine functionalized fullerene nanoparticles with enhanced antibacterial activity.","authors":"Abed Alqader Ibrahim, Tariq Khan, Kyle Nowlin, Jared Averitt, Gayani Pathiraja, Dennis LaJeunesse, Sherine O Obare, Anthony L Dellinger","doi":"10.1039/d4na00732h","DOIUrl":"10.1039/d4na00732h","url":null,"abstract":"<p><p>Nanoparticle modification demonstrates a remarkable synergetic effect in combating bacteria, particularly resistant bacteria, enhancing their efficacy by simultaneously targeting multiple cellular pathways. This approach positions them as a potent solution against the growing challenge of antimicrobial-resistant (AMR) strains. This research presents an investigation into the synthesis, characterization, and antibacterial evaluation of silver-coordinated chloro-fullerenes nanoparticles (Ag-C₆₀-Cl) and copper-coordinated chloro-fullerenes nanoparticles (Cu-C₆₀-Cl). Utilizing an innovative, rapid one-step synthesis approach, the nanoparticles were rigorously characterized using X-ray Photoelectron Spectroscopy (XPS), Scanning Electron Microscopy-Energy Dispersive X-ray Spectrometer (SEM-EDS), High-Resolution Transmission Electron Microscopy (HR-TEM), Fourier-Transform Infrared Spectroscopy (FTIR), and Raman spectroscopy. In conjunction with the analytical techniques, a computational approach was utilized to corroborate the findings from Raman spectroscopy as well as the surface potential of these nanoparticles. Moreover, the antibacterial activities of the synthesized nanoparticles were assessed against <i>Escherichia coli</i> (<i>E. coli</i>) and Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA). These findings demonstrated that the synthesized Ag-C₆₀-Cl and Cu-C₆₀-Cl nanoparticles exhibited minimum inhibitory concentrations (MIC) of 3.9 μg mL^-1 and 125 μg mL^-1, respectively. Reactive oxygen species (ROS) quantification, catalase assay, and efflux pump inhibition results revealed promising broad-spectrum antibacterial effects.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive review of challenges and advances in exosome-based drug delivery systems.","authors":"Sushesh Srivatsa Palakurthi, Brijesh Shah, Sumedha Kapre, Nitin Charbe, Susan Immanuel, Sindhura Pasham, Maharshi Thalla, Ankit Jain, Srinath Palakurthi","doi":"10.1039/d4na00501e","DOIUrl":"10.1039/d4na00501e","url":null,"abstract":"<p><p>Exosomes or so-called natural nanoparticles have recently shown enormous potential for targeted drug delivery systems. Several studies have reported that exosomes as advanced drug delivery platforms offer efficient targeting of chemotherapeutics compared to individual polymeric nanoparticles or liposomes. Taking structural constituents of exosomes, <i>viz.</i>, proteins, nucleic acids, and lipids, into consideration, exosomes are the most promising carriers as genetic messengers and for treating genetic deficiencies or tumor progression. Unfortunately, very little attention has been paid to the factors like source, scalability, stability, and validation that contribute to the quality attributes of exosome-based drug products. Some studies suggested that exosomes were stable at around -80 °C, which is impractical for storing pharmaceutical products. Currently, no reports on the shelf-life and <i>in vivo</i> stability of exosome formulations are available. Exosomes are quickly cleared from blood circulation, and their <i>in vivo</i> distribution depends on the source. Considering these challenges, further studies are necessary to address major limitations such as poor drug loading, reduced <i>in vivo</i> stability, a need for robust, economical, and scalable production methods, <i>etc.</i>, which may unlock the potential of exosomes in clinical applications. A few reports based on hybrid exosomes involving hybridization between different cell/tumor/macrophage-derived exosomes with synthetic liposomes through membrane fusion have shown to overcome some limitations associated with natural or synthetic exosomes. Yet, sufficient evidence is indispensable to prove their stability and clinical efficacy.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supramolecular chirality in self-organised systems and thin films","authors":"G. Giancane, S. Bettini and L. Valli","doi":"10.1039/D4NA90108H","DOIUrl":"10.1039/D4NA90108H","url":null,"abstract":"<p >A graphical abstract is available for this content</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142550077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable pH-responsive polypeptide hydrogels for local delivery of doxorubicin.","authors":"Yijun Guo, Yong Chen, Yiqun Wu, Ying Zhu, Shiyao Luo, Juan Shen, Yongjun Luo","doi":"10.1039/d4na00719k","DOIUrl":"10.1039/d4na00719k","url":null,"abstract":"<p><p>Cancer, as a global health threat, is often treated with chemotherapy, but its effect is limited, especially the drugs such as doxorubicin (DOX) are limited by their non-specificity and side effects. This study focuses on developing a new drug delivery system to overcome these challenges. Based on the self-assembling peptide hemopressin (HP), we designed and screened FOK peptide, which serves as a pH-responsive carrier with excellent pH sensitivity and mechanical stability. At a concentration of 20 mg mL^-1, FOK can spontaneously form a stable hydrogel, efficiently encapsulating DOX with an encapsulation rate exceeding 95%. This system can gradually release the drug in the tumor-specific mildly acidic environment, achieving precise delivery and sustained release of the drug. Rheological analysis revealed the superior mechanical and self-healing properties of FOK hydrogel, suitable for injection delivery with long-lasting stability. Mouse experiments showed that DOX/FOK hydrogel significantly inhibited tumor growth while greatly reducing toxicity. In conclusion, FOK hydrogel, as a delivery vehicle for DOX, not only optimizes the precise delivery and sustained release mechanism of DOX, but also reduces treatment side effects, opening up new avenues for the application of peptide hydrogels in cancer therapy and providing a scientific basis for designing efficient drug delivery systems.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of a novel nanomagnetic N₄ bis schiff base complex of copper(ii) as an efficient catalyst for click synthesis of tetrazoles.","authors":"Chou-Yi Hsu, Ahmed Rafiq AlBajalan, Sameer A Awad, Muath Suliman, Nizomiddin Juraev, Carlos Rodriguez-Benites, Hamad AlMohamadi, Abed J Kadhim","doi":"10.1039/d4na00642a","DOIUrl":"10.1039/d4na00642a","url":null,"abstract":"<p><p>In this study, we have prepared a novel bis-Schiff-base copper(ii) complex by modifying Fe₃O₄ with acetylacetone functionalities and subsequently forming a Schiff base with 2-picolylamine and CuCl₂ through a template method. Immobilization of 2,4-pentanedione and its reaction with 2-picolylamine enabled the synthesis of 1,3-diketimines (HNacNac) as an anionic ligand. This unique design resulted in a tetradentate N₄ coordination sphere for copper(ii) ion complexation. The resulting heterogeneous catalyst, [Fe₃O₄@Sil-Schiff-base-Cu(ii)], efficiently catalyzed the click condensation of diverse aryl nitriles with sodium azide to produce 5-substituted 1<i>H</i>-tetrazoles in high yields and selectivity. The catalyst demonstrated remarkable stability and recyclability without appreciable loss of catalytic activity, as confirmed by hot filtration and reusability studies.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RuC nanosheet as a promising biosensing material for detecting the aromatic amino acids: a DFT study.","authors":"Mahmoud A A Ibrahim, Nada K M Ahmed, Amna H M Mahmoud, Mohamed A El-Tayeb, Ashraf M M Abdelbacki, Shahzeb Khan, Mahmoud E S Soliman, Tamer Shoeib","doi":"10.1039/d4na00670d","DOIUrl":"10.1039/d4na00670d","url":null,"abstract":"<p><p>Density functional theory (DFT) calculations were performed to examine the potential of the RuC nanosheet as a biosensor towards the aromatic amino acids (AAA; tryptophan (TRP), histidine (HIS), tyrosine (TYR), and phenylalanine (PHE)). The AAA molecules were placed vertically and horizontally with respect to the RuC surface and then subjected to geometrical relaxation. According to the geometry relaxation results, it was found that all AAA molecules preferred to be adsorbed on the RuC surface in a horizontal configuration rather than a vertical one, except the HIS molecule, which desired to be vertically adsorbed on the RuC nanosheet. From the energy manifestations, the adsorption process within the TRP⋯RuC complexes had the greatest desired negative adsorption energy (<i>E</i> _ads), followed by HIS⋯, TYR⋯, and then PHE⋯RuC complexes (<i>E</i> _ads = -40.22, -36.54, -23.95, and -16.62 kcal mol^-1, respectively). As indicated by the FMO data, changes in the <i>E</i> _HOMO, <i>E</i> _LUMO, and <i>E</i> _gap values of the RuC nanosheet following the adsorption process demonstrated the capacity of the RuC nanosheet to adsorb the AAA molecules. The outcomes of Bader charge transfer revealed that the RuC nanosheet had the ability to donate electrons to the AAA molecules during the adsorption process, supported by the positive <i>Q</i> _t values. Consistent with the <i>E</i> _ads conclusions, the TRP⋯RuC complexes had the largest <i>Q</i> _t values, indicating the potential affinity of the RuC nanosheet to adsorb the TRP molecule. Following the adsorption of AAA molecules on the RuC nanosheet, new peaks and bands were discovered based on the DOS and the band structure plots, respectively, revealing the validity of the adsorption process. Additionally, the current adsorption findings on the RuC nanosheet were compared to those on the graphene (GN) nanosheet. The outcomes of the comparison demonstrated the outperformance of the RuC nanosheet over the GN nanosheet in adsorbing the AAA molecules. These outcomes provide a solid foundation for further research on the RuC nanosheets to detect small biomolecules.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Freon-CO₂-assisted purification of single-walled carbon nanotubes.","authors":"Yiman Huang, Xiao Zhu, Tao Chen, Hongyan Li, Liang Han, Xilai Jia","doi":"10.1039/d4na00610k","DOIUrl":"10.1039/d4na00610k","url":null,"abstract":"<p><p>With the rapidly growing applications, efficient purification of single-walled carbon nanotubes (SWCNTs) has become one of the key problems. This paper proposes Freon-CO₂-assisted purification of SWCNTs, where CO₂ can oxidize the graphitized carbon layer to expose iron (Fe) impurities, while the chlorine from Freon can react with the Fe impurities to form low-boiling-point metal chlorides that can be eliminated in a gas stream. After an acid washing with a very small amount of hydrochloric acid, the last remaining metal impurities are removed and highly pure SWCNTs are produced. Compared with traditional strong-acid-oxidation purification or high-temperature-vacuum purification, this method can maintain the structure and length of the SWCNTs. Raman spectra show that an <i>I</i> _G/<i>I</i> _D ratio of more than 100 can be obtained. This purification method can maintain the microstructure and excellent properties of SWCNTs and provide a solution for the preparation of high-quality SWCNTs to exert their properties.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-counterfeiting labels of photonic crystals with versatile structural colors.","authors":"Nguyen Hoang Minh, Kwanoh Kim, Do Hyun Kang, Yeong-Eun Yoo, Jae Sung Yoon","doi":"10.1039/d4na00814f","DOIUrl":"10.1039/d4na00814f","url":null,"abstract":"<p><p>Labels with structural color based on photonic crystals (PCs) have drawn significant attention due to their unique color emission, offering promising solutions for anti-counterfeiting applications. However, to meet the demands of future high-security applications, conventional structural color labels require further improvement. This study introduces a novel approach to fabricate highly encrypted anti-counterfeiting labels by combining close-packed and non-close-packed monolayers of nanoparticles (NPs) onto adhesive surfaces. The photonic crystals, arranged in specific geometric shapes, exhibit overt-covert characteristics. The hidden label is only revealed under specific external triggers, such as attaching or removing a transparent cover film. The principle of color modulation of the photonic crystal is elucidated, highlighting the role of packing density and refractive index matching. Additionally, the scalability and cost-effectiveness of the fabrication process in this study are expected to facilitate future commercialization. Various anti-counterfeiting applications, including water-responsive labels and multi-layer authentication, are demonstrated also, which enables higher security levels and versatility of this study.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MoS₂ quantum dot-decorated CNT networks as a sulfur host for enhanced electrochemical kinetics in advanced lithium-sulfur batteries.","authors":"Meng Wei, Hanqing Lu, Zhen Wang, Baowen Lu, Pengtao Wang, Xinxin Zhang, Bingjie Feng, Yingjie Xie, Tao Zhang, Guanghui Liu, Song Xu","doi":"10.1039/d4na00068d","DOIUrl":"10.1039/d4na00068d","url":null,"abstract":"<p><p>The slow redox kinetics and shuttle effect of polysulfides severely obstruct the further development of lithium-sulfur (Li-S) batteries. Constructing sulfur host materials with high conductivity and catalytic capability is well acknowledged as an effective strategy for promoting polysulfide conversion. Herein, a well-designed MoS₂ QDs-CNTs/S@Ni(OH)₂ (labeled as MoS₂ QDs-CNTs/S@NH) cathode was synthesized <i>via</i> a hydrothermal process, in which conductive polar MoS₂ quantum dot-decorated carbon nanotube (CNT) networks coated with an ultrathin Ni(OH)₂ layer acted as an efficient electrocatalyst. MoS₂ QD nanoparticles with a high conductivity and catalytic nature can enhance the kinetics of polysulfide conversion, expedite Li₂S nucleation, and decrease the reaction energy barrier. The thin outer Ni(OH)₂ layer physically confines active sulfur and meanwhile provides abundant sites for adsorption and conversion of polysulfides. Benefiting from these merits, a battery using MoS₂ QDs-CNTs/S@NH as the sulfur host cathode exhibits excellent electrochemical performances with rate capabilities of 953.7 mA h g^-1 at 0.1C and 606.6 mA h g^-1 at 2.0C. A prominent cycling stability of a 0.052% decay rate per cycle after 800 cycles is achieved even at 2C.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the catalytic potency of a novel hydrazone-linked covalent organic framework for the highly efficient one-pot synthesis of 1,2,4-triazolidine-3-thiones†","authors":"Pankaj Teli, Shivani Soni, Sunita Teli and Shikha Agarwal","doi":"10.1039/D4NA00650J","DOIUrl":"10.1039/D4NA00650J","url":null,"abstract":"<p >A novel hydrazone-linked covalent organic framework (TRIPOD-DHTH COF) was synthesized through the ultrasonic treatment of 2,5-dihydroxyterephthalohydrazide (DHTH) and 4,4′,4′′-[1,3,5-triazine-2,4,6-triyltris(oxy)]tris-benzaldehyde (TRIPOD). The COF was extensively analyzed using FT-IR, PXRD, SEM, TEM, BET, XPS, TGA, and DTA techniques. The characterization studies revealed the presence of mesoporous properties and high thermal stability, with a surface area measuring 2.78 m<small>²</small> g<small>⁻¹</small> and an average pore size of 8.88 nm. The developed COF demonstrated exceptional catalytic activity in synthesizing 1,2,4-triazolidine-3-thiones from thiosemicarbazide and various ketones and aldehydes using a water : ethanol (1 : 2) medium at room temperature. A significant yield (80–98%) of 1,2,4-triazolidine-3-thiones was obtained in a low reaction time (4–20 min). The role of TRIPOD as a precursor in the synthesis of the COF and as a reactant in the synthesis of 1,2,4-triazolidine-3-thione (<strong>3l</strong>) was found to be fascinating. The synthesized COF maintained its catalytic activity over eight runs, underscoring its efficiency and reusability, highlighting its potential for sustainable chemical syntheses.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}