Nanoscale Advances最新文献

{"title":"Stretchable heat-dissipation sheet based on insulating graphene and boron nitride composites: asymmetric elastomeric networks for stable thermal conductivity under repeated tensile strain.","authors":"Sang-Mi Jeong, Taekyung Lim, Jonguk Yang, Hee Sung Seo, Sanghyun Ju","doi":"10.1039/d5na00373c","DOIUrl":"https://doi.org/10.1039/d5na00373c","url":null,"abstract":"<p><p>As modern electronic devices become smaller and more highly integrated, stable thermal management is emerging as a key development approach, including in applications considering mechanical deformation. In this study, a flexible heat-dissipating sheet was developed using composites of insulating graphene (I-Gr), plate-like boron nitride (BN-P), and aggregated spherical BN (BN-A) based on a high-elasticity styrene-(ethylene-butylene)-styrene (SEBS) elastomer. The unique asymmetric two-dimensional layered structure of I-Gr and BN improved the heat transfer properties of the composite by maintaining the continuity of the heat-conducting network despite tensile deformation. In addition, the spherical shape and disordered structure of the aggregated BN-A promoted the formation of an extended heat-conducting path and enhanced the bonding between the fillers. At the optimal composition, the composite maintained an initial thermal conductivity (TC) of 2.0 W m^-1 K^-1 or higher, and the TC reduction (ΔTC) was less than 8% and 10% at 50% and 100% elongation, respectively, demonstrating excellent TC stability. In addition, owing to the interfacial affinity and network reinforcing effect of I-Gr, the TC performance and structural stability were maintained even after 500 cycles of 50% tensile strain and 400% elongation. In contrast, the CNT-based composite showed limitations such as low initial TC, large ΔTC, and low elongation. This study presents a design strategy for a heat-dissipating material with high elasticity, high TC, and excellent durability, offering considerable potential for use in next-generation flexible electronic devices such as wearable electronics, freeform displays, and soft robotics.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of interface dielectric disorder on interlayer excitons in mixed binary/ternary TMD heterostructures.","authors":"Mohammed Adel Aly, Emmanuel Oghenevo Enakerakpor, Hilary Masenda, Martin Koch","doi":"10.1039/d4na00786g","DOIUrl":"10.1039/d4na00786g","url":null,"abstract":"<p><p>In this paper, we study the excitonic linewidths and peak energies in two transition metal dichalcogenide heterostructures of Mo_0.5W_0.5Se₂ and its binary counterparts, MoSe₂ and WSe₂. We observe spectra composed of several individual excitonic transitions in temperature-dependent photoluminescence measurements. Among these are transitions of neutral excitons and trions from the binary layers and the interlayer excitons from the heterostructures. The luminescence linewidth of the interlayer excitons is significantly broader than the linewidths of the excitonic transitions from the binary layers. We attribute this additional line broadening to dielectric disorder caused by spatial inhomogeneity at the interface.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12290915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evolution of integrated magnetic hyperthermia and chemodynamic therapy for combating cancer: a comprehensive viewpoint.","authors":"Anjali Chauhan, Anamika Saini, Deepika Sharma","doi":"10.1039/d4na01004c","DOIUrl":"10.1039/d4na01004c","url":null,"abstract":"<p><p>Magnetic hyperthermia therapy (MHT) and chemodynamic therapy (CDT) are emerging non-invasive cancer treatments that leverage reactive oxygen species (ROS) to induce tumor cell death. While MHT uses magnetic nanoparticles to generate localized heat under an alternating magnetic field, its efficacy can be limited by low ROS levels in hypoxic tumor microenvironments. CDT complements MHT by inducing toxic hydroxyl radicals through Fenton reactions, enhancing ROS production and antitumor effects. This mini-review discusses the synergistic potential of combining MHT with CDT using multifunctional nanomaterials, offering insights into enhanced ROS-mediated cancer therapy and future directions for clinical applications.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12285877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outstanding Reviewers for <i>Nanoscale Advances</i> in 2024.","authors":"","doi":"10.1039/d5na90045j","DOIUrl":"https://doi.org/10.1039/d5na90045j","url":null,"abstract":"<p><p>We would like to take this opportunity to thank all of <i>Nanoscale Advances</i> reviewers for helping to preserve quality and integrity in the chemical science literature. We would also like to highlight the Outstanding Reviewers for <i>Nanoscale Advances</i> in 2024.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12284593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molybdenum carbide supported metal-organic framework-derived Ni, Co phosphosulphide heterostructures as efficient OER and HER catalysts.","authors":"Muhammad Ahsan Naseeb, Maida Murtaza, Komal Farooq, Waqas Ali Shah, Amir Waseem","doi":"10.1039/d5na00510h","DOIUrl":"10.1039/d5na00510h","url":null,"abstract":"<p><p>Molybdenum carbide (Mo _<i>x</i> C) has gained attention for water splitting due to its electronic structure resembling to Pt and have high electrochemical performance. We designed porous nanostructured phosphorus/sulfur co-doped Ni, Co phosphosulphide and molybdenum carbide heterostructures Mo _<i>x</i> C(Mo₂C-MoC) through confined carburization within a metal-organic framework (MOF) matrix combined with a phosphosulfurization strategy. Starting from a carbon source consisting of NiCo-MOF incorporating molybdenum trioxide, we prepared MOF-derived NiCo-Mo _<i>x</i> C nanorods <i>via</i> carbonization, which exhibited decent electrocatalytic performance for the hydrogen evolution reaction (HER) by electrochemical water splitting. The NiCo-Mo _<i>x</i> C showed low overpotentials of 153 mV and 157 mV <i>vs.</i> RHE at a current density of 10 mA cm^-2 in 0.5 M H₂SO₄ and 1 M KOH, respectively. Phosphosulfurization of NiCo-Mo _<i>x</i> C, performed under controlled conditions, resulted in the formation of NiPS-CoPS-Mo _<i>x</i> C, which demonstrated superior HER performance than the precursor NiCo-Mo _<i>x</i> C with overpotentials of 75.2 mV and 86.6 mV in 0.5 M H₂SO₄ and 1 M KOH, respectively and an overpotential of 184.5 mV at 10 mA cm^-2 for the oxygen evolution reaction (OER). The durability of the NCMCSP-based electrolyzer for the overall water splitting was evaluated by measuring the voltage over time at a constant current density of 20 mA cm^-2 for 12 h.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the impact of bioinspired counterion inclusion on silk nanoparticle physicochemical attributes and physical stability.","authors":"Napaporn Roamcharern, Panida Punnabhum, F Philipp Seib, Zahra Rattray","doi":"10.1039/d5na00365b","DOIUrl":"https://doi.org/10.1039/d5na00365b","url":null,"abstract":"<p><p>Silk fibroin is a promising material for nanocarrier-based drug delivery applications due to its biocompatibility, biodegradability, and mechanical properties, which can be fine-tuned through processing conditions. In this study, we explore the impact of Ca²⁺ and K⁺ inclusion on the morphology of silk nanoparticles and evaluate the short- and long-term stability of silk nanoparticles formed by antisolvent precipitation in deionized water and sodium phosphate buffer. Using advanced electric asymmetric flow field-flow fractionation multiplexed with online detectors (EAF4-UV-MALS-DLS) and orthogonal analytics (DLS, ELS, NTA, FE-SEM), we analyze the physicochemical attributes of silk nanoparticles. We find significant differences in nanoparticle architecture and stability in different buffers, with notable differences in particle size (<i>R</i> _g and <i>R</i> _h), charge, and shape measured over 56 days. Notably, nanoparticles formulated with 0.7 mg Ca²⁺ and 1.1 mg K⁺ maintained superior physicochemical stability, making them promising candidates for future nanocarrier-based applications.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triazoles synthesis using nanocatalyst triazine-pyrimidine-modified cobalt-based metal-organic frameworks.","authors":"Mahtab Amirian, Ramin Ghorbani-Vaghei, Sedigheh Alavinia","doi":"10.1039/d5na00299k","DOIUrl":"https://doi.org/10.1039/d5na00299k","url":null,"abstract":"<p><p>This research introduces a recyclable and environmentally friendly catalyst, Co(BDC-NH₂)-TA-PY, for the efficient synthesis of triazoles <i>via</i> the reaction of benzaldehydes, nitromethane, and sodium azide. The synthesis of Co(BDC-NH₂)-TA-PY was carried out through the post-synthetic modification of Co(BDC-NH₂), incorporating triazine-pyrimidine (TA-PY) functional groups. The key advantage of this catalyst lies in its dual functionality: the Lewis acidic sites of the Co(BDC-NH₂) metal-organic framework (MOF) are complemented by the Brønsted basic sites of the triazine and pyrimidine groups. This study represents the first example of a post-synthetic modification of the Co(BDC-NH₂) metal-organic framework (MOF) by integrating triazine and pyrimidine functional groups, which significantly enhanced its catalytic performance. The abundant TA-PY ligand increased the catalytic activity from 42% to 94%. Co(BDC-NH₂) nanocrystals were successfully synthesized and characterized, exhibiting a highly crystalline structure. Following the post-synthetic modification to synthesize Co(BDC-NH₂)-TA-PY, the catalyst retained its uniform morphology, ensuring consistent structural integrity. Furthermore, the structural integrity, morphology, and chemical composition of the reused Co(BDC-NH₂)-TA-PY were thoroughly examined, revealing no significant differences between the fresh and reused catalysts. These results highlight the potential of functionalized cobalt-based metal-organic frameworks as versatile and sustainable catalysts for broader organic reactions.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cobalt-nickel metal-organic frameworks (CNMs) as drug delivery agents for triple-negative breast cancer.","authors":"Shaik Sameer Basha, Abhishek Sasmal, Subastri Ariraman, Mukilarasi B, Thilak Raj, Vimalraj Selvaraj, A Arockiarajan, Swathi Sudhakar","doi":"10.1039/d5na00193e","DOIUrl":"https://doi.org/10.1039/d5na00193e","url":null,"abstract":"<p><p>Breast cancer is one of the most prevalent cancers worldwide, with triple-negative breast cancer (TNBC) representing a particularly aggressive subtype, making it difficult to treat, and is associated with a poor prognosis. However, chemotherapy is associated with challenges such as drug resistance, off-target toxicity, and limited efficacy, highlighting the need for more effective therapies. Nanocarriers, including liposomes, micelles, and dendrimers, offer improved drug delivery efficacy and reduced toxicity but face challenges in terms of stability and scalability. Metal-organic frameworks (MOFs) have emerged as promising drug delivery systems, particularly for combination therapies to overcome resistance in TNBC. In this study, cobalt-nickel metal-organic frameworks (CNMs) were synthesized and loaded with a combination of cisplatin (Cis), doxorubicin (Dox), and 5-fluorouracil (5-Fu) (MD-CNM) to develop a novel multidrug delivery system. The MD-CNM exhibited high biocompatibility, an efficient drug loading capacity of 95.44 ± 4.05%, and sustained release over 96 h. Moreover, the MD-CNM demonstrated potent cytotoxicity against MDA-MB-231 breast cancer cells, with an IC₅₀ concentration of 461 nM, which is two- to five-fold less than the IC₅₀ value of individual drugs (Cis, Dox, and 5-Fu) loaded with the CNM, indicating enhanced therapeutic efficacy. Additionally, flow cytometry analysis revealed that the MD-CNM induced necrosis (77.59%) and late apoptosis (12.37%) with cell cycle arrest in the G₀/G₁ phase, further confirming its anticancer potential. Furthermore, the <i>ex ovo</i> chorioallantoic membrane (CAM) assay demonstrated that the MD-CNM significantly inhibited tumor angiogenesis by downregulating key pro-angiogenic factors, including vascular endothelial growth factor A (VEGFA), fibroblast growth factor 2 (FGF2), and angiopoietin 1 (ANG1) within the tumor microenvironment. These findings underscore the potential of CNMs as an innovative and efficient multidrug delivery platform for targeted cancer therapy, particularly for treating TNBC, offering a promising alternative to conventional chemotherapy with improved efficacy and reduced toxicity.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144743156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: A nanomagnetic triazole-based Schiff-base complex of palladium(0) as an efficient heterogeneous catalyst for the Mizoroki-Heck C-C cross-coupling reaction under green conditions.","authors":"Yassin T H Mehdar, Fatimah Mohammed Alshamsan, Asma Ahmad Nashawi, Hussein Eledum, Ahmed Mohajja Alshammari, Jawza A Almutairi","doi":"10.1039/d5na90046h","DOIUrl":"https://doi.org/10.1039/d5na90046h","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1039/D5NA00364D.].</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12268600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flame-made nanoparticles for magnetic hyperthermia and MRI in colorectal cancer theranostics.","authors":"Yuming Zhang, Christina Paraskeva, Qianying Chen, Anano Maisuradze, Shaquib Rahman Ansari, Tapati Sarkar, Vasiliki Koliaraki, Alexandra Teleki","doi":"10.1039/d5na00603a","DOIUrl":"10.1039/d5na00603a","url":null,"abstract":"<p><p>Magnetic hyperthermia therapy using superparamagnetic iron oxide nanoparticles (SPIONs) offers a promising strategy for treating cancers resistant to chemo- and radiotherapy. However, oral delivery of SPIONs for localized treatment of gastrointestinal cancers has not been widely explored. Here, we report the development of methoxy polyethylene glycol (mPEG) functionalized SPIONs (mPEG-Mn_0.6Zn_0.4Fe₂O₄) engineered for oral administration with combined theranostic functionalities for magnetic hyperthermia treatment and magnetic resonance imaging (MRI) in colorectal cancer (CRC). The SPIONs achieved consistent heating performance in biorelevant colonic environments, exceeding a 5 °C temperature increase within 10 min under an alternating magnetic field (AMF). They also demonstrated superior <i>r</i> ₂ relaxivity compared to γ-Fe₂O₃, highlighting their potential as effective <i>T</i> ₂ MRI contrast agents. <i>In vitro</i> studies using CRC SW480 and Caco-2 cell lines assessed nanoparticle cytotoxicity, cellular uptake, and magnetic hyperthermia efficacy in both upright and inverted cell culture configurations. Magnetic hyperthermia induced significant CRC cell death <i>in vitro</i>, particularly in upright configurations, attributed to enhanced localized heating caused by nanoparticle sedimentation and enhanced SPION contact with cell surfaces. This emphasizes the importance of <i>in vitro</i> experimental parameters such as cell line, configuration, and AMF exposure time for systematic optimization of theranostic SPIONs during preclinical development. Finally, <i>in vivo</i> studies using a colorectal tumor xenograft mouse model demonstrated a marked therapeutic effect of magnetic hyperthermia by intratumorally injected SPIONs. The tumor volume was reduced by 63% following a single 20-minute AMF exposure. These findings demonstrate the potential of mPEG-Mn_0.6Zn_0.4Fe₂O₄ nanoparticles as a promising platform for non-invasive, image-guided magnetic hyperthermia therapy in CRC theranostics.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12281419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}