The evolution of integrated magnetic hyperthermia and chemodynamic therapy for combating cancer: a comprehensive viewpoint.

Abstract

Magnetic hyperthermia therapy (MHT) and chemodynamic therapy (CDT) are emerging non-invasive cancer treatments that leverage reactive oxygen species (ROS) to induce tumor cell death. While MHT uses magnetic nanoparticles to generate localized heat under an alternating magnetic field, its efficacy can be limited by low ROS levels in hypoxic tumor microenvironments. CDT complements MHT by inducing toxic hydroxyl radicals through Fenton reactions, enhancing ROS production and antitumor effects. This mini-review discusses the synergistic potential of combining MHT with CDT using multifunctional nanomaterials, offering insights into enhanced ROS-mediated cancer therapy and future directions for clinical applications.