Nanoscale Advances最新文献

{"title":"Impact of synthesis methods on the functionality of antibody-conjugated gold nanoparticles for targeted therapy.","authors":"Adi Anaki, Chen Tzror-Azankot, Menachem Motiei, Tamar Sadan, Rachela Popovtzer","doi":"10.1039/d4na00134f","DOIUrl":"https://doi.org/10.1039/d4na00134f","url":null,"abstract":"<p><p>Gold nanoparticles (GNPs) are emerging as promising modular platforms for antibody-based cancer therapeutics. Their unique physiochemical properties enable efficient binding of multiple antibodies upon a single particle, thereby enhancing therapeutic potential. However, the effect of widely used synthesis techniques on the characteristics and functionality of antibody-GNP platforms has yet to be fully understood. Here, we investigated the effect of key synthesis approaches, namely, covalent binding and physical adsorption, on the properties and anti-cancer functionality of antibody-coated GNPs. By carefully manipulating synthesis variables, including antibody mass in reaction and linker compositions, we revealed a direct impact of these synthesis methods on antibody binding efficiency and anti-cancer functionality. We found that covalent binding of antibodies to GNPs generated a platform with increased cancer cell killing functionality as compared to the adsorption approach. Additionally, a higher antibody mass in the synthesis reaction and a higher polyethylene glycol linker ratio upon covalently bound antibody-GNPs led to increased cell death. Our findings emphasize the critical role of synthesis strategies in determining the functionality of targeted GNPs for effective cancer therapy.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11372556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and bioactivity of a novel surfactin-based lipopeptide for mRNA delivery.","authors":"Mohammed S Alqahtani, Rabbani Syed, Ali S Alqahtani, Omer M Almarfadi, Monzurul A Roni, Satya S Sadhu","doi":"10.1039/d4na00404c","DOIUrl":"https://doi.org/10.1039/d4na00404c","url":null,"abstract":"<p><p>The effective delivery of messenger ribonucleic acid (mRNA) to specific cell types and target tissues poses a significant challenge in nonviral therapeutic strategies. Lipid-based nanoparticles (LNPs) have emerged as a leading carrier system for delivering mRNA, particularly for infectious diseases, such as COVID-19. This study aimed to describe the synthesis of a novel lipopeptide based on surfactin, a naturally occurring surfactant. Additionally, a series of novel LNPs were rationally designed, based on the modified surfactin, OleSurf, and were formulated and optimized. The physicochemical properties, morphologies, and stabilities of the particles were evaluated. All formulations containing OleSurf produced particles with a diameter <80 nm and an encapsulation efficiency >95%. OleSurf LNPs demonstrated excellent transfection efficiency and luciferase expression with no cytotoxicity, compared to lipofectamine 2000, a known transfection reagent, and were comparable to the DLin-MC3-DMA lipid. OleSurf-based LNPs behaved as efficient mRNA carriers and showed enhanced mRNA-binding capabilities, associated with facilitated intracellular release, endosomal escape, and protection from endonuclease degradation. In addition, OleSurf-LNPs showed a higher mRNA delivery efficiency, a more advantageous biodistribution pattern, and an improved safety profile <i>in vivo</i>. Overall, the novel OleSurf LNPs presented an optimal delivery platform for mRNA therapeutics.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth mechanism of 2D heterostructures of polypyrrole grown on TiO₂ nanoribbons for high-performance supercapacitors.","authors":"Abeer Enaiet Allah, Fatma Mohamed","doi":"10.1039/d4na00121d","DOIUrl":"https://doi.org/10.1039/d4na00121d","url":null,"abstract":"<p><p>The patterning of functional structures is crucial in the field of materials science. Despite the enticing nature of two-dimensional surfaces, the task of directly modeling them with regular structures remains a significant challenge. Here we present a novel method to pattern a two-dimensional polymer in a controlled way assisted by chemical polymerization, which is confirmed through discernible observation. The fabrication process involves <i>in situ</i> polymerization to create 2D layers of polypyrrole (PPy) on extended 2D TiO₂ nanoribbons, resulting in oriented arrays known as 2D PPy/TiO₂. These arrays exhibit enhanced electrochemical performance, making them ideal for supercapacitor applications. The skeleton structure of this material is distinctive, characterized by a homogeneous distribution of layers containing various elements. Additionally, it possesses a large contact surface, which effectively reduces the distance for ion transport and electron transfer. The 2D PPy/TiO₂ electrode has a maximum specific capacitance of 280 F g^-1 at an applied current density of 0.5 A g^-1. Moreover, it demonstrates excellent rate capability and cycling stability. Therefore, this approach will open an avenue for improving polymerization-based patterning toward recommended applications.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tunable Insulator-Metal transition in Epitaxial VO2 thin film via strain and defect engineering","authors":"Aditya Kamat, Gurukrishna Kaleyathodi, Rishow Kumar, Abhishek Mishra, Amit K. Verma, Shivam Tripathi, Ashish Garg, Shikhar Misra","doi":"10.1039/d4na00682h","DOIUrl":"https://doi.org/10.1039/d4na00682h","url":null,"abstract":"The Metal to Insulator Transition (MIT) in materials, particularly Vanadium Dioxide (VO2), has garnered significant research interest due to its potential applications in smart windows, memristors, transistors, sensors, and optical switches. The transition from an insulating, monoclinic phase to a conducting, tetragonal phase involves changes in optical and electrical properties, opening up avenues in adaptive radiative coolers, optical memories, photodetectors, and optical switches. VO2 exhibits MIT near 68°C, thereby requiring tunable transition temperatures (Tc) in VO2 thin films for practical device applications. In this work, we explore the role of strain and defect engineering towards tuning the MIT temperature in epitaxial VO2 thin films deposited on c-cut sapphire using Pulsed Laser Deposition (PLD). The study involves tuning the metal-to-insulator transition (MIT) by varying growth parameters, mainly temperature and oxygen partial pressure. Strain engineering along the b-axis helped tune the transition temperature from 65°C to 82°C with the out-of-plane b-strain varying from -0.71% to -0.44%. Comprehensive structural and property analyses, including X-ray diffraction (XRD), Reciprocal Space Mapping (RSM), X-ray Dispersive Spectroscopy (XPS), Raman spectroscopy, and Resistivity-Temperature (R-T) measurements, were performed to correlate structural properties with Tc. Additionally, ab-initio DFT calculations were performed on Quantum Espresso using generalized gradient approximation of the revised Perdew-Burke-Ernzerhof (PBEsol) to provide theoretical validity to the experimentally obtained results. Our study provides critical insights of the interplay between strain and oxygen vacancies and their effect on the physical properties in VO2 thin films with DFT calculations supporting the experimental findings.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Polymorphism vs Shape of Titania Nanocrystals towards Hydrogen Evolution Reaction","authors":"Ankur Yadav, Vivek Agrahari, Yuriy Pihosh, Mamiko Nakabayashi, Wojciech Nogala, Balendu Giri, Kazunari Domen, Daya Shankar Pandey, Bhavana Gupta, Subha Sadhu","doi":"10.1039/d4na00479e","DOIUrl":"https://doi.org/10.1039/d4na00479e","url":null,"abstract":"In this report, we investigated the impact of polymorphism vs dimension control of titania nanocrystals towards hydrogen generation. Two different forms of titania nanoparticles have been synthesized following solvothermal method leading to the formation of two distinct physicochemical features. Detail structural, morphological, and optical studies revealed the formation of titania nanorods correspond to rutile while granular particles correspond to anatase phase. Among various titania polymorphs anatase is well known for superior photocatalytic activity but to our surprise, the as-synthesized rutile nanorods exhibited higher catalytic activity in comparison to anatase spheres and hydrogen evolution was significantly enhanced after addition of diminutive amount of Pt as co-catalyst. Thus, despite of higher catalytic activity of anatase, the enhanced hydrogen evolution of rutile nanorods may be related to the creation of a1D structure. Our study highlights the importance of considering not only TiO2 polymorphism, but also shape and dimension, in optimizing photocatalytic H2 production.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic atom co-sharing and S-scheme heterojunction: constructing Cu/CuO/Cu₂O with ultrathin graphene-like carbon derived from basil seeds for enhanced photo-oxidation of benzyl alcohols to aldehydes.","authors":"Zahra Kohansal Nalkyashree, Nadiya Koukabi, Kheibar Dashtian, Farzad Seidi","doi":"10.1039/d4na00283k","DOIUrl":"https://doi.org/10.1039/d4na00283k","url":null,"abstract":"<p><p>This study is centered on the oxidative transformation of alcohols into their respective aldehyde compounds, employing an S-scheme heterostructure featuring CuO/Cu₂O on graphene-like carbon (GLC) derived from a basil seed hydrogel. Experimental characterization and theoretical calculations highlight that the implementation of S-scheme heterostructures achieves not only enhanced charge-separation efficiency, facilitated by the interfacial built-in electric field, Cu co-sharing at the CuO/Cu₂O interface, and electron carrier activity of the GLC support, but also maintains a strong driving force for photocatalytic organic conversion. The resulting nanocomposites play a crucial role in transferring and reducing the recombination of photoexcited charge carriers, preserving the oxidizability of CuO holes and the reducibility of Cu₂O electrons. Through meticulous adjustment of precursor amounts, the CuO-Cu₂O/GLC heterojunction exhibited the highest photocurrent at 6.83 mA cm^-2, demonstrating optimal performance in the photocatalytic selective oxidation of benzyl alcohol with an average conversion rate of 95.0%. Furthermore, the stability of CuO-Cu₂O/GLC was thoroughly investigated, revealing sustained high conversion even after five repeated experiments, underscoring its potential for practical applications. The study also proposes a plausible mechanism for the transformation of benzyl alcohol into benzaldehyde through capture experiments of active species. Importantly, this research introduces a straightforward <i>in situ</i> hydrothermal growth protocol for efficiently constructing metal oxide heterostructures wrapped in an rGO support. It provides valuable insights into designing new synthetic strategies for preparing efficient photocatalysts and hints at the development of novel, efficient, and practical photocatalytic systems.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atomic diffraction by nanoholes in hexagonal boron nitride.","authors":"Eivind Kristen Osestad, Ekaterina Zossimova, Michael Walter, Bodil Holst, Johannes Fiedler","doi":"10.1039/d4na00322e","DOIUrl":"10.1039/d4na00322e","url":null,"abstract":"<p><p>Fabricating patterned nanostructures with matter waves can help to realise new nanophotonic devices. However, due to dispersion effects, designing patterns with nanoscale features is challenging. Here, we consider the propagation of a helium matter wave through different holes in hexagonal boron nitride (h-BN) as a case study for the weakest dispersion interaction and the matter wave's diffraction as it passes through the holes. We use a quantum-mechanical model to calculate the polarisability of edge atoms around the holes, where we observe polarisation ripples of enhanced and reduced polarisabilities around the holes. We use these values to calculate van der Waals dispersion coefficients for the scattered helium atoms. We find that the resulting diffraction patterns are affected by the shape and size of the holes, where the smallest holes have a radius of just 6 Å. These results can be used to predict the resolution limits of nano-hole patterns on nanophotonic materials.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of silver-decorated PLGA nanoparticles on Staphylococcus epidermidis biofilms and evaluation of detoxification limit of bacteria against these nanoparticles","authors":"Chisato Takahashi, Keiichi Moriguchi","doi":"10.1039/d4na00249k","DOIUrl":"https://doi.org/10.1039/d4na00249k","url":null,"abstract":"Silver nanoparticles exert high antibacterial activity and thus have been used in polymeric formulations for drug delivery. In recent years, polymeric formulations containing silver nanoparticles have been found to be highly effective against biofilm infections, which are difficult to treat with drugs only. However, the antibacterial effects of silver nanoparticles in polymer composites depending on administration time are still unknown. In this study, we used transmission electron microscopy to investigate the antibacterial activity of silver decorated poly (DL-lactide-co-glycolide) (PLGA) (Ag PLGA) nanoparticles against <em>Staphylococcus epidermidis</em> biofilms at different treatment times. LIVE/DEAD assay result showed that approximately 85% of the bacteria in the biofilms was killed after 6 h of administering the Ag PLGA nanoparticles. The formulation comprising Ag PLGA nanoparticles was found to be highly effective and to exhibit low cytotoxicity. However, silver nanoparticles were ejected from the bacterial cells up to 4 h after treatment administration due to the self-protection properties of the bacteria. On the basis of the results, we propose a potential mechanism for the antibacterial activity of silver nanoparticles per treatment time, taking into account the detoxification activity of bacterial cells. This information can contribute not only to an understanding of foreign-body elimination but also to the design of effective formulations against biofilm infections.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142175721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrowetting on glassy carbon substrates.","authors":"Sittipong Kaewmorakot, Athanasios A Papaderakis, Robert A W Dryfe","doi":"10.1039/d4na00506f","DOIUrl":"https://doi.org/10.1039/d4na00506f","url":null,"abstract":"<p><p>The wetting properties of carbon surfaces are important for a number of applications, including in electrochemistry. An under-studied area is the electrowetting properties of carbon materials, namely the sensitivity of wetting to an applied potential. In this work we explore the electrowetting behaviour of glassy carbon substrates and compare and contrast the observed response with our previous work using highly oriented pyrolytic graphite. As with the graphite substrate, \"water-in-salt\" electrolytes are found to suppress faradaic processes, thereby enlarging the electrochemical potential window. A notable difference in response to positive and negative polarity was seen for the graphite and glassy carbon substrates. Moreover, whereas graphite has previously been shown to give a reversible electrowetting response over many cycles, an irreversible wetting was observed for glassy carbon. Similarly, the timescales of the wetting process were much faster on the graphitic substrate. Reasons underlying these marked changes in behaviour on the different carbon surfaces are suggested.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11378016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HF-free microwave-assisted synthesis of MXene as an electrocatalyst for hydrogen evolution in alkaline media.","authors":"Kajal Mahabari, Ranjit D Mohili, Monika Patel, Arvind H Jadhav, Kwangyeol Lee, Nitin K Chaudhari","doi":"10.1039/d4na00250d","DOIUrl":"https://doi.org/10.1039/d4na00250d","url":null,"abstract":"<p><p>MXenes, characterized by their robustness, flexibility, and large surface-to-volume ratio facilitating efficient energy transfer with fast response times, have emerged as promising electrocatalysts for hydrogen generation through electrochemical water-splitting. However, the conventional synthetic route to MXenes typically involves the use of hydrofluoric acid (HF) to obtain MXenes with terminal F-functional groups. Unfortunately, these fluorine groups can negatively impact the electrocatalytic performance of MXenes. Moreover, HF is highly toxic, necessitating the development of more environmentally friendly synthetic methods. In response to these challenges, we have developed a novel HF-free microwave-assisted synthesis approach for MXenes. This method harnesses the benefits of uniform heating, homogeneous nucleation, and rapid crystal development, resulting in MXene crystallites with limited size. Importantly, our microwave-assisted approach utilizes a fluoride-free, less hazardous etchant as compared to HF for the synthesis and functionalization of MXene. The as-obtained MXene exhibits significantly improved performance towards the electrochemical hydrogen evolution reaction in alkaline media. Specifically, it demonstrates an overpotential of 140 mV at a current density of 10 mA cm^-2 and a Tafel slope of 84 mV dec^-1. These results highlight the potential of our HF-free microwave-assisted synthesis approach for producing high-quality MXenes with enhanced electrocatalytic activity for hydrogen generation.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11376077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}