Nanoscale Advances最新文献

{"title":"A mesoporous silica-based MRI/NIR-II fluorescence bimodal nanoprobe for precision detection and surgical navigation of sentinel lymph node metastasis.","authors":"Renhai Feng, Hui Wang, Siyi Tao, Kuang Xu, Ke Xu, Yongxiao Mou, Zhifa Shen, Jiaxi Ru, Can Shao","doi":"10.1039/d6na00444j","DOIUrl":"10.1039/d6na00444j","url":null,"abstract":"<p><p>Precise detection of sentinel lymph node (SLN) metastasis is critical for accurate cancer staging and effective surgical navigation. In this study, we developed a high-performance magnetic resonance imaging (MRI)/near-infrared (NIR)-II fluorescence imaging nanoplatform by integrating the NIR dye IR820 and the gadolinium-based MRI contrast agent (GdL) into mesoporous silica nanoparticles (MSNs) using bovine serum albumin (BSA) as the functional component. This nanoplatform exhibits strong NIR-II fluorescence tail emission and high longitudinal relaxivity, enabling dual-modality imaging for the diagnosis of primary tumors and metastatic lymph nodes, as well as NIR-II fluorescence-guided surgery (FGS). Within this system, BSA not only serves as a structural stabilizer but also significantly enhances IR820 fluorescence emission and improves GdL relaxivity. Notably, two types of surface-functionalized MSNs, amine- and thiol-modified, were systematically compared, and the thiol-modified MSNs exhibited superior imaging performance, including a red-shifted absorption peak and markedly enhanced NIR-II fluorescence emission. <i>In vitro</i> and <i>in vivo</i> experiments confirmed that the dual-modality nanoprobe accumulated efficiently in tumors and SLNs, enabling high-sensitivity MRI localization and high-resolution NIR-II fluorescence imaging of metastatic lesions. Overall, this study presents a surface-engineering strategy to enhance the imaging performance of MRI/NIR-II nanoprobes, offering a promising approach for accurate diagnosis of lymph node metastasis and real-time FGS.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13539382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic field-guided enhancement of nanoparticle uptake and hyperthermia efficacy in 3D tumour models.","authors":"Lilianne Beola, Lucía Gutiérrez, Raluca M Fratila, Jesús M de la Fuente, Laura Asín, Valeria Grazú","doi":"10.1039/d6na00172f","DOIUrl":"10.1039/d6na00172f","url":null,"abstract":"<p><p>Magnetic hyperthermia (MH) using iron oxide nanoparticles (MNPs) is a promising cancer treatment strategy, yet its efficacy strongly depends on efficient intracellular nanoparticle delivery. Here, we compared two strategies to enhance MNP uptake by tumour cells: (i) increasing the administered MNP dose and (ii) applying a static magnetic field (MF) gradient to promote nanoparticle-cell interactions and increase availability at the cell surface. Human tumour cell lines, representing distinct challenges for nanoparticle internalisation due to differences in growth behaviour and cellular organisation, were first incubated with glucose-functionalised 11 nm MNPs under two-dimensional (2D) culture conditions to control and quantify intracellular uptake under each strategy. Cells with pre-internalised MNPs were then embedded in collagen-based three-dimensional (3D) tumour models, where MH was applied and therapeutic efficacy was evaluated by confocal microscopy and flow cytometry. While both strategies increased intracellular MNP levels, only MF-assisted internalisation resulted in effective MH-induced cytotoxicity under mild conditions across all tested cell lines. These findings indicate that antitumour MH efficacy is not solely determined by nanoparticle uptake, but also by the strategy used to enhance internalisation, revealing an additional layer of complexity for designing efficient MH protocols.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13523097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the thermal and aqueous stability of 1D lepidocrocite titania.","authors":"Risha A Iythichanda, Sukanya Maity, Mustafa Mahmoud Aboulsaad, Tomas Edvinsson, Johanna Rosen, Per O Å Persson","doi":"10.1039/d6na00382f","DOIUrl":"https://doi.org/10.1039/d6na00382f","url":null,"abstract":"<p><p>One-dimensional (1D) lepidocrocite titanium dioxide (TiO₂) filaments are investigated with respect to their thermal and aqueous stability. Structural and phase evolution are examined by <i>in situ</i> heating in vacuum using (scanning) transmission electron microscopy combined with electron energy loss spectroscopy and under ambient conditions using Raman spectroscopy. The filaments retain their lepidocrocite structure up to ∼300 °C, above which localized sintering and amorphization occur at filament overlap junctions. With further heating, the amorphous regions crystallize into anatase TiO₂, with Raman spectroscopy corroborating the onset of structural disorder. Long-term aqueous storage (>100 days) under ambient conditions induces transformation into flake-like anatase nanoparticles. This process is strongly suppressed under refrigerated storage, where no structural changes are observed over the same period. These results establish critical thermal and environmental stability thresholds that define operational advantages and limits for emerging applications of 1D lepidocrocite TiO₂ filaments.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13492517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-dimensional molybdenum disulfide nanoparticles intercalated between graphite layers: TEM observation and desulfurization behaviour.","authors":"Koya San-Yoshi, Takehiko Sasaki, Takeshi Kubota, Norihito Sakaguchi, Masayuki Shirai","doi":"10.1039/d6na00539j","DOIUrl":"10.1039/d6na00539j","url":null,"abstract":"<p><p>Two-dimensional molybdenum disulfide nanoparticles were formed in graphite interlayers by sulfurization and reduction-sulfurization treatments of a molybdenum chloride-intercalated graphite compound (MoCl₅-GIC). When MoCl₅-GIC was treated at 623 or 823 K under a flowing mixed gas of hydrogen sulfide and hydrogen, molybdenum disulfide nanosheets (MoS₂-GIC(i)) with a thickness of 1-2 layers and lateral dimensions extending over several hundred nanometers were obtained. In contrast, when MoCl₅-GIC was first reduced at 873 K under a hydrogen flow and subsequently sulfurized at 823 K under a mixed gas of hydrogen sulfide and hydrogen, molybdenum disulfide clusters (MoS₂-GIC(ii)) with lateral dimensions of several tens of nanometers and consisting of 4-5 stacked layers were formed in the graphite interlayers. MoS₂-GIC(i) and MoS₂-GIC(ii) exhibited comparable catalytic activities for the hydrogenation of naphthalene; however, in the hydrodesulfurization of dibenzothiophene, MoS₂-GIC(ii) showed higher desulfurization selectivity.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13501475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Casimir-mediated amplification of flexural modes in suspended graphene.","authors":"Sofia Ribeiro, Hugo Terças","doi":"10.1039/d6na00471g","DOIUrl":"https://doi.org/10.1039/d6na00471g","url":null,"abstract":"<p><p>We develop a minimal theoretical framework to describe near-field Casimir-mediated coupling between two suspended nanomembranes: a graphene sheet and a gold-coated GaAs membrane separated by a micrometer-scale vacuum gap. Coherent excitation of flexural (out-of-plane) modes in the gold membrane, provided by an external piezoelectric drive, enables efficient energy transfer to graphene through static vacuum electromagnetic coupling. Using a coupled-mode description equivalent to the classical equations of motion, we identify hybridized flexural modes exhibiting avoided crossings, tunable spectral response, and drive-dependent energy exchange. Under experimentally accessible conditions, Casimir-mediated mode hybridisation transfers energy from the driven gold membrane to graphene at rates comparable to or exceeding the intrinsic mechanical losses of graphene, resulting in a strong enhancement of its flexural response and linewidth narrowing. The Casimir interaction acts here solely as a static, non-contact coupling mechanism, while all energy is supplied externally through coherent mechanical driving, yielding drive-induced amplification without intrinsic negative damping. Our results establish Casimir coupling as a practical resource for controlling flexural dynamics in graphene nanomembranes and provide a platform for non-contact energy transfer and mode-selective amplification in two-dimensional mechanical systems.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13484937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applications of conductive hydrogels in sports performance monitoring.","authors":"Jiahang Liu, Xiuya Zhang, Shijun Liu","doi":"10.1039/d6na00545d","DOIUrl":"10.1039/d6na00545d","url":null,"abstract":"<p><p>Conductive hydrogels, as functional materials with softness, electrical conductivity, and biocompatibility, have attracted increasing attention in the field of sports performance monitoring in recent years. Compared with traditional rigid sensors, conductive hydrogels can better conform to the skin and soft tissues, enabling stable and continuous signal acquisition during high-intensity exercise and in complex environments. This review comprehensively summarizes recent advances in the application of conductive hydrogels for sports monitoring, with a particular focus on material design strategies, conductive mechanisms, and key performance characteristics. Furthermore, typical application scenarios are discussed, including joint posture tracking, impact force measurement, electromyographic signal acquisition, sweat analysis, and feedback during rehabilitation training. The major challenges currently facing this field are also analyzed, such as insufficient durability, performance degradation in high-humidity environments, technical bottlenecks in multimodal synchronous signal acquisition, complex fabrication processes, and the lack of standardized evaluation systems. Finally, potential future development directions are proposed, including intelligence, multimodal integration, industrial translation, and green sustainable development. Conductive hydrogels are expected to become core materials for next-generation wearable sports monitoring devices, providing strong support for scientific training, injury prevention, and personalized rehabilitation.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13519909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introducing a CoFe₂O₄@CS-BAPT/Cu^II nanocomposite as an efficient catalyst for the synthesis of 4<i>H</i>-pyran derivatives.","authors":"Mohammad Ali Bodaghifard, Najmieh Ahadi, Mojdeh Ordouzadeh","doi":"10.1039/d6na00486e","DOIUrl":"10.1039/d6na00486e","url":null,"abstract":"<p><p>This study introduces the development of an innovative and environmentally friendly bio-nanocatalyst (CoFe₂O₄@CS-BAPT/Cu^II nanocomposite), designed and employed for three-component synthesis of 2-amino-3-cyano-4<i>H</i>-pyrans. Chitosan (CS) as a biodegradable polymer was functionalized with bis(2-aminopyridine)triazine (BAPT) moieties. Subsequently, CoFe₂O₄ magnetic nanoparticles (MNPs) were incorporated and copper ions were immobilized on the composite to form the final magnetic nanocomposite (CoFe₂O₄@CS-BAPT/Cu^II). Characterization techniques such as Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray (EDX) analysis, vibrating sample magnetometry (VSM), inductively coupled plasma atomic emission spectroscopy (ICP-OES), dynamic light scattering (DLS), and zeta potential were used to analyze the nanocomposite structure. XRD analysis showed a near-amorphous structure after functionalizing CoFe₂O₄ with chitosan. FE-SEM images revealed uniform particles without aggregation, with an average size of 12-14 nm. TGA indicated thermal stability up to 300 °C. CoFe₂O₄@CS-BAPT/Cu^II was successfully used in the green synthesis of 2-amino-3-cyano-4<i>H</i>-pyrans with potential biological properties. The desired products were synthesized with high yields (83-95%) in short reaction times (20-45 minutes). Furthermore, the catalyst exhibited easy magnetic separation and good reusability, highlighting its potential as an efficient and sustainable heterogeneous catalyst. Key advantages of this approach include the use of an easily accessible bio-polymer, environmentally friendly catalytic protocols, a simplified and cost-effective synthesis process, clean reactions that generate no additional waste, and the reusable nature of the catalyst.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A synergistic antioxidant nanozyme platform for corneal neovascularization treatment.","authors":"Min Su, Tingxiu Ye, Wei Yuan, Bochao Zhang, Jinfa Ye, Chuan Chen, Chengchao Chu","doi":"10.1039/d6na00297h","DOIUrl":"10.1039/d6na00297h","url":null,"abstract":"<p><p>Corneal neovascularization (CNV) is recognized as one of the most common blinding eye diseases, afflicting millions of individuals globally each year. Substantial evidence has demonstrated that oxidative stress and inflammation constitute pivotal pathogenic factors in the initiation and progression of CNV. In this study, we prepared a synergistic nanozyme platform for the antioxidant therapy of CNV. Specifically, we co-assembled manganese(iii) <i>meso</i>-tetra(4-carboxyphenyl)porphine (Mn-TCPP) with octahydrated zirconium(iv) chloride, followed by surface modification with platinum nanoparticles (Pt NPs), preparing the Pt NPs-Mn-TCPP@Zr (PMTZ) nanomedicine. The prepared PMTZ nanomedicine showed enhanced antioxidant performance, which could inhibit the migration of human umbilical vein epithelial cells and eliminate excessive reactive oxygen species produced by oxidative stress cells. Finally, PMTZ was applied in the treatment of CNV, and its therapeutic efficacy was confirmed through experimental validation.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13523096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148851029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep eutectic solvent-enabled green synthesis of gold nanoparticle-decorated ZIF-L composites for colorimetric detection of trimethoprim.","authors":"Trung Hieu Vu, Ngoc Xuan Dat Mai, Nhu Hoa Thi Tran, Nae Yoon Lee, Kieu The Loan Trinh","doi":"10.1039/d6na00106h","DOIUrl":"10.1039/d6na00106h","url":null,"abstract":"<p><p>Developing environmentally friendly synthesis strategies for metal-organic frameworks (MOF) and their hybrid nanocomposites is critical to creating sustainable, high-performance materials for analytical sensing applications. In this study, a gold nanoparticle-decorated ZIF-L (ZIF-L/Au) composite was synthesized <i>via</i> a deep eutectic solvent (DES)-assisted green synthesis, thereby providing enhanced stability and improved dispersion of Au nanoparticles and minimizing the use of hazardous organic solvents. The DES-stabilized ZIF-L/Au composite exhibited strong peroxidase-like activity toward ABTS˙⁺ radical scavenging, effectively decolorizing it from green to transparent. Notably, the presence of trimethoprim (TMP) inhibited this catalytic decolorization, leading to a concentration-dependent restoration of the green color. Under optimized conditions, the ZIF-L/Au composite enabled colorimetric detection of TMP with high sensitivity and selectivity, with a limit of detection of 4.38 nM. This work provides a sustainable strategy for constructing functional MOF-based hybrid nanomaterials and demonstrates their strong potential for practical, on-site monitoring of antibiotic residues.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":6.3,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular dynamics insights into the interfacial interactions of natural rubber and nylon 6,6 with carbon nanotubes.","authors":"Rima Biswas, Surya S Urs","doi":"10.1039/d6na00426a","DOIUrl":"10.1039/d6na00426a","url":null,"abstract":"<p><p>The microscopic structure, interfacial energetics, and localized transport kinetics of natural rubber (NR) and nylon 6,6 (NY) matrices close to bare, hydroxylated (-OH), and carboxylated (-COOH) carbon nanotubes (CNTs) were examined using molecular dynamics simulations (MD). Surface functionalization significantly modifies interfacial polymer physics, as shown by radial and spatial distribution functions, which act through completely different mechanisms for polar thermoplastics and non-polar elastomers. The hierarchy of diffusivity for non-polar NR is <i>D</i> _COOH-CNT > <i>D</i> _OH-CNT > <i>D</i> _bare-CNT. On bare CNTs, hydrophobic wetting encourages dense packing and severe mobility suppression, while polar modifications increase the local free volume by introducing steric hindrance and thermodynamic de-wetting. On the other hand, transport kinetics are completely inverted in polar NY (<i>D</i> _bare-CNT > <i>D</i> _OH-CNT > <i>D</i> _COOH-CNT). Strong, multi-point interfacial hydrogen bonds and an intense nonbonded binding energy of -262.433 kcal mol^-1 are established by carboxyl groups, which energetically trap the polyamide segments and significantly limit molecular hopping. Additionally, surface functionalization causes both matrices to undergo a conformational change that results in a strictly parallel alignment along the nanotube axis. These insights provide crucial design rules for tailoring interfacial shear strength and load transfer in high-performance nanocomposites.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":"4945-4956"},"PeriodicalIF":6.3,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13470682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}