Nanoscale Advances最新文献

{"title":"An AlFe₂O₄@SiO₂-SO₃H innovative nanocatalyst: a sustainable approach for the A3 coupling reaction in a DES for 2-thioarylbenzoazoles.","authors":"Ahmad Sajjadi, Suranjana V Mayani, Suhas Ballal, Shaker Al-Hasnaawei, Abhayveer Singh, Kattela Chennakesavulu, Kamal Kant Joshi","doi":"10.1039/d5na00247h","DOIUrl":"10.1039/d5na00247h","url":null,"abstract":"<p><p>The A3 coupling reaction, which facilitates the synthesis of 2-thioarylbenzoazoles, represents a significant transformation in organic chemistry with implications in drug discovery and materials science. In this study, we introduce a novel nanocatalyst, AlFe₂O₄@SiO₂-SO₃H, designed to enhance the efficiency and sustainability of this reaction. The catalyst is synthesized by functionalizing aluminum ferrite (AlFe₂O₄) with chlorosulfonic acid (Cl-SO₃H), promoting its role as an effective acid catalyst. Utilizing deep eutectic solvents (DESs) as a green reaction medium further contributes to the sustainability of the process by providing a biodegradable and non-toxic environment. Optimization studies were conducted to determine the optimal reaction conditions, including catalyst loading, temperature, and solvent composition. Characterization of the nanocatalyst was performed using techniques such as X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier-transform infrared spectroscopy (FTIR) to confirm successful synthesis and functionalization. The AlFe₂O₄@SiO₂-SO₃H nanocatalyst exhibited excellent catalytic activity, resulting in high yields of 2-thioarylbenzoazoles under mild conditions while allowing for easy recovery and reuse without significant loss of activity. This work demonstrates the potential of AlFe₂O₄@SiO₂-SO₃H as a sustainable catalytic system for A3 coupling reactions, contributing to the development of environmentally friendly methodologies in organic synthesis.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced photocatalytic degradation of methylene blue dye <i>via</i> valorization of a polyethylene terephthalate plastic waste-derived metal-organic framework-based ZnO@Co-BDC composite catalyst.","authors":"Biniyam Abdu Berehe, Ali Ahmed Desalew, Getahun Worku Derbe, Derese Moges Misganaw, Kedir Seid Mohammed, Jia-Yaw Chang, Wubshet Mekonnen Girma","doi":"10.1039/d4na01071j","DOIUrl":"10.1039/d4na01071j","url":null,"abstract":"<p><p>The growth of industrialization contributes to the pollution of natural water bodies. Among these pollutants, organic dyes and plastic waste materials account for the majority of contaminants and are associated with health risks. This research explores a metal-organic framework (MOF)-based composite catalyst, ZnO@Co-BDC, for the degradation of methylene blue (MB). We developed a Co-BDC MOF synthesized through a solvothermal route using terephthalic acid (BDC) as a linker, which was extracted from polyethylene terephthalate plastic waste <i>via</i> alkaline hydrolysis, and using cobalt nitrate hexahydrate as a cobalt source. The ZnO@Co-BDC composite catalyst was synthesized through a solvothermal route using cobalt, BDC and zinc precursors. The obtained products were characterized using powder X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, and ultraviolet diffuse reflectance spectroscopy (UV-DRS). The performance of ZnO@Co-BDC was assessed for the degradation of MB and showed 87.5% under visible light irradiation for 80 min, surpassing pristine ZnO (74%) and Co-BDC MOF (39%) under the same conditions. The kinetic study indicated that the degradation followed first-order kinetics with a rate constant of 2.501 × 10^-2 min^-1. Furthermore, the effects of catalyst dose, irradiation time, pH, and MB concentration were optimized for the efficient composite catalyst ZnO@Co-BDC. The photodegradation mechanism was also investigated through UV-DRS and quenching experiments in the presence of different scavengers. Meanwhile, the developed composite demonstrated excellent recovery and reuse capabilities for up to six cycles under optimal conditions. The developed MOF-based composite catalyst enabled the simultaneous valorization of plastic waste and remediation of environmental pollutants by converting waste to wealth.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12091243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermal conductivity of graphene coated copper under uniaxial tensile mechanical strain.","authors":"Micah P Vallin, Hisato Yamaguchi, Rijan Karkee, Chanho Lee, Ramon M Martinez, Saryu J Fensin, Jun Beom Park, Hi Tin Vo, Richard Z Zhang, Michael T Pettes","doi":"10.1039/d5na00088b","DOIUrl":"10.1039/d5na00088b","url":null,"abstract":"<p><p>Graphene continues to demonstrate promise as a highly effective barrier coating, even at only one atom thick. The thermal properties of this coating are also promising to allow diffusion of heat across the surface, as the isolated graphene is an intrinsically good thermal conductor. However, this and its behavior under mechanical deformation have been less extensively studied. This report demonstrates that the in-plane thermal conductivity and interfacial thermal conductance of graphene coatings on copper are affected by mechanical strain. By inducing strain in the copper substrate, the Raman-active 2D peak exhibits a change in position and a change in laser power dependence as the copper substrate is uniaxially elongated to a maximum of 0.5%. Non-linear trends in thermal conductivity are observed with tensile strain in samples with differing strain transfer rates from the substrate, indicating the close correlation between intrinsic thermal conduction and interfacial properties in atomically thin coatings transferred onto metals.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymer/AgPt bimetallic nanoparticle synergy: optimizing plasmonic durability through controlled synthesis and matrix integration.","authors":"Abeer Fahes, Lavinia Balan, Caroline Andreazza-Vignolle, Claudia de Melo, Didier Zanghi, Pascal Andreazza","doi":"10.1039/d5na00187k","DOIUrl":"https://doi.org/10.1039/d5na00187k","url":null,"abstract":"<p><p>An innovative approach combining UV-induced polymerization and ultra-high vacuum (UHV) atomic vapor deposition was developed to synthesize and disperse 2-3 nm AgPt bimetallic nanoparticles (BNPs) within a non-porous poly (dipropylene glycol diacrylate) (PDGDA) matrix, surpassing conventional porous polymer strategies. This method offers unprecedented control over the structural properties of BNPs and in general nanoalloys, with the polymer matrix playing a critical role in regulating nanoparticle formation, spatial arrangement, and size uniformity. The PDGDA matrix enhances nanoparticle stability through steric stabilization and controlled diffusion, effectively maintaining small nanoparticle sizes (∼2.4-2.8 nm) and low dispersity (<i>σ</i> _D/<i>D</i> = 0.16) during extended high-temperature annealing. Confinement of nanoparticles (NPs) was significantly accelerated by successive thermal annealing to 320 °C, which increased polymer chain mobility and reduced viscosity, enabling rapid diffusion while preserving the structural integrity of the polymer matrix. This process dramatically reduced the embedding time from 12 days at room temperature to near-instantaneous incorporation upon heating. Successful confinement is attributed to key thermodynamic factors that promote interfacial interactions and particle mobility within the polymer network. Experimental results reveal distinctive UV plasmonic properties of the embedded AgPt BNPs with long-term stability. The produced AgPt BNPs exhibit significantly stronger localized surface plasmon resonances (LSPRs) than pure platinum nanoparticles, attributed to synergistic effects between the two metals. Factors contributing to this enhancement include silver's high electrical conductivity and relatively low optical losses, electromagnetic coupling, and localized electric field enhancement, highlighting the potential of these BNPs for advanced plasmonics. This research addresses the growing demand for surface-enhanced Raman scattering (SERS) detection of UV-absorbing biospecies and the development of more efficient broad-spectrum solar cells.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monodisperse spherical Ag⁺ doped Cs₂KBiCl₆ nanocrystals: utilizing steric hindrance engineering for inkjet printing of anti-counterfeiting patterns.","authors":"Shaoli Song, Youlun Zhu, Hanmei Jiang, Huichao He, Qian Yang, Jianbei Qiu, Tao Han","doi":"10.1039/d4na00988f","DOIUrl":"10.1039/d4na00988f","url":null,"abstract":"<p><p>Anti-counterfeiting is one of the critical application fields of luminescent materials. Nanocrystal luminescent materials are more suitable for anti-counterfeiting applications because they are tiny and more conducive to patterning. The preparation of monodisperse and spherical lead-free perovskite nanocrystals by a propagable method is a hot topic in anti-counterfeiting materials. In this work, monodisperse spherical Ag⁺ doped Cs₂KBiCl₆ nanocrystals with an average diameter of 3.51 nm were prepared by using the propagable ligand-assisted reprecipitation method at room temperature, attributed to steric hindrance engineering by increasing the ligand size. Due to relaxation of the transition barrier due to doping, excited with 365 nm ultraviolet light, the nanocrystals exhibit orange emission peaking at 600 nm, which is related to the transition recombination of Bi³⁺ (¹S₀ → ³P₁), and the maximum photoluminescence quantum yield is 3.80%. A printable ink is prepared by combining the nanocrystals with PDMS adhesive and its curing agent, which can be used for inkjet printing of anti-counterfeiting patterns.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of CsPbBr₃ decorated ZIF-8 nanocomposite for enhanced photocatalytic performance.","authors":"Alen Sam Thomas, Philip Nathaniel Immanuel, Neena Prasad, Achiad Goldreich, Jonathan Prilusky, Raanan Carmieli, Lena Yadgarov","doi":"10.1039/d5na00217f","DOIUrl":"https://doi.org/10.1039/d5na00217f","url":null,"abstract":"<p><p>CsPbBr₃ (CPB) perovskite nanocrystals (NCs) have attracted considerable interest due to their outstanding charge carrier mobility, long diffusion lengths, and efficient visible light absorption, making them ideal candidates for photocatalysis, light-emitting diodes (LEDs), solar cells, and photodetectors. However, their practical applications are limited by poor environmental stability. To address this challenge, we employ a zeolitic imidazolate framework (ZIF), specifically ZIF-8, as a stabilizing matrix for its exceptional thermal and chemical stability, high surface area, and versatile synthesis routes. The CPB/ZIF-8 nanocomposite was synthesized by integrating hot-injection-produced CPB NCs with ZIF-8 using an optimized mixing approach, ensuring a uniform NCs distribution. Electron microscopy (EM) analysis confirmed the well-controlled and uniform distribution of the NCs on the surface of the ZIF-8. Moreover, the Fourier-transform infrared spectroscopy (FTIR) revealed ligand exchange, where the imidazole linkers of the ZIF-8 structure replace the NCs ligands. The process advances almost epitaxial attachment of the latter, thus promoting effective charge interactions in the integration process. Indeed, we observe that upon formation of the composite, there is a 92% quenching in the photoluminescence (PL) of the NCs. This finding further indicates efficient charge separation and reduced electron-hole recombination. To gain deeper insight into the charge transfer mechanisms, we conducted electron paramagnetic resonance (EPR) measurements to compare the radical generation capabilities of CPB and ZIF with those of the CPB/ZIF composite. The composite exhibited superior radical generation capabilities, particularly hydroxyl radicals (˙OH), indicating enhanced charge transfer. These findings suggest that the composite is a highly promising candidate for photocatalysis. Building on these findings, we explored the photocatalytic abilities of the composite through dye degradation experiments, using methyl orange (MO) and bromocresol green (BCG) as model dyes. The CPB/ZIF nanocomposite demonstrated significantly enhanced photocatalytic performance compared to pristine ZIF and CPB NCs. Specifically, its degradation rates were 1.48× and 1.75× higher for MO and BCG, respectively, than those of CPB NCs. This improvement highlights the effective interaction between CPB NCs and ZIF, establishing the CPB/ZIF nanocomposite as a promising material for photocatalysis and optoelectronic applications.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simple, scalable protocol for the synthesis of ricinoleic acid-functionalised superparamagnetic nanoparticles with tunable size, shape, and hydrophobic or hydrophilic properties.","authors":"Sohel Reja","doi":"10.1039/d5na00150a","DOIUrl":"10.1039/d5na00150a","url":null,"abstract":"<p><p>Vegetable oils such as oleic acid have been widely used in the synthesis of nanomaterials as they are environmentally benign, cheap, and biodegradable. Ricinoleic acid (RA), which differs from oleic acid by the presence of an additional hydroxyl group, has surprisingly remained unexplored in the preparation of metal oxide nanoparticles, although it offers the advantage over oleic acid of easy functionalization due to the presence of the hydroxyl group. Here is a simple one-pot procedure for the synthesis of a variety of superparamagnetic nanoparticles, iron oxides and ferrites, using RA both as a precursor complexing agent and as a capping agent outlined. This procedure overcomes the challenges associated with the traditional thermal decomposition method, which demands separate precursor preparation and purification steps, thus promoting a simple yet scalable economic production of various magnetic nanoparticles. Minor changes in the reaction conditions allowed for the production of nanoparticles with different sizes, ranging from 5 to 17 nm, as well as different shapes, spherical and cuboid. Iron oxide nanospheres with an average particle size of 10 nm were superparamagnetic at room temperature with a saturation magnetization of 41 emu g^-1. The as-prepared RA-coated nanoparticles are hydrophobic and dispersible in non-polar solvents but may easily be rendered hydrophilic and water dispersible; epoxidation, followed by alkaline ring-opening, produced hydroxylated nanoparticles with a positive zeta potential of 31 eV, whereas exchange of the capping RA with nitrilotriacetic acid (NTA) gave nanoparticles with a negative zeta potential of -25 eV. The present study highlights the uniqueness of using RA in the preparation of magnetic nanoparticles; apart from the ease and economics of scaling, it offers the possibility of the nanoparticles being either hydrophobic or hydrophilic.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12096511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-resolved nanospectroscopy of III-V semiconductor nanowires.","authors":"Andrei Luferau, Alexej Pashkin, Stephan Winnerl, Maximilian Obst, Susanne C Kehr, Emmanouil Dimakis, Thales V A G de Oliveira, Lukas M Eng, Manfred Helm","doi":"10.1039/d5na00307e","DOIUrl":"https://doi.org/10.1039/d5na00307e","url":null,"abstract":"<p><p>We investigate ultrafast electron dynamics in individual GaAs/InGaAs core-shell nanowires using near-infrared pump-mid-infrared probe nanospectroscopy based on a scattering-type scanning near-field technique. Our results reveal a distinct blue shift in plasmon resonance frequency induced by photodoping. By extracting time-dependent electron densities and scattering rates, we gain insights into the effects of chemical doping and nanowire surface states on recombination dynamics and carrier mobility. Varying the pump power over two orders of magnitude reveals carrier recombination times in the range from a few ps at high power to 100 ps at low power, dominated by bimolecular recombination. Our findings highlight the potential of time-resolved nanoscopy for contactless probing of free carrier mobility and recombination dynamics on a local scale in individual semiconductor nanostructures or nanodevices.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144033482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Development and in vitro and ex vivo characterization of a twin nanoparticulate system to enhance ocular absorption and prolong retention of dexamethasone in the eye: from lab to pilot scale optimization","authors":"Muhammad Sarfraz, Gautam Behl, Sweta Rani, Niall O'Reilly, Peter McLoughlin, Orla O'Donovan, Alison L. Reynolds, John Lynch and Laurence Fitzhenry","doi":"10.1039/D5NA90032H","DOIUrl":"https://doi.org/10.1039/D5NA90032H","url":null,"abstract":"<p >Correction for ‘Development and <em>in vitro</em> and <em>ex vivo</em> characterization of a twin nanoparticulate system to enhance ocular absorption and prolong retention of dexamethasone in the eye: from lab to pilot scale optimization’ by Muhammad Sarfraz <em>et al.</em>, <em>Nanoscale Adv.</em>, 2025, https://doi.org/10.1039/d4na01086h.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 10","pages":" 3143-3143"},"PeriodicalIF":4.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/na/d5na90032h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization, and evaluation of low molecular weight poly(β-amino ester) nanocarriers for enhanced T cell transfection and gene delivery in cancer immunotherapy.","authors":"Alireza Gharatape, Ali Sayadmanesh, Hamid Sadeghi-Abandansari, Hossein Ghanbari, Mohsen Basiri, Reza Faridi-Majidi","doi":"10.1039/d5na00169b","DOIUrl":"https://doi.org/10.1039/d5na00169b","url":null,"abstract":"<p><p>Cancer immunotherapy represents a revolutionary approach in cancer treatment by leveraging the body's immune system to target and eliminate cancer cells. An emerging strategy within this field is gene delivery, which can enhance the efficacy of immune cells. Nanocarrier-based gene delivery methods have gained prominence due to their ability to protect and transport genetic material into cells efficiently. Polymeric nanocarriers, in particular, offer significant advantages, such as customizable physical and chemical properties, biocompatibility, and the potential for targeted delivery. Among polymeric nanocarriers, poly(β-amino ester) (PBAE) polymers are notable for their biodegradability, low cytotoxicity, and high gene transfection efficiency. This study investigates the synthesis and characterization of low molecular weight PBAE nanocarriers, assessing their potential in gene delivery applications for Jurkat and primary T cells-both crucial in cancer immunotherapy. Our research involved synthesizing PBAE polymer and creating nanocarriers at various DNA-to-polymer ratios. We characterized these nanocarriers in terms of size, zeta potential, and encapsulation efficiency. Confocal microscopy and flow cytometry were utilized to evaluate cellular uptake and transfection efficiency. The results demonstrated appropriate transfection efficiency and significant gene expression in both hard-to-transfect cell types (jurkat up to 37% and primary T cell 5%), with optimized DNA-to-polymer ratios showing minimal cytotoxicity. This study highlights the potential of PBAE nanocarriers in enhancing gene delivery for cancer immunotherapy. By effectively transfecting T cells, these nanocarriers could improve the therapeutic outcomes of immunotherapy, offering a promising pathway for developing more effective cancer treatments.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}