Nanoscale Advances最新文献

{"title":"Microfluidic generation of nanoparticles using standing wave induced ultrasonic spray drying.","authors":"Holger Bolze, Keiran Mc Carogher, Simon Kuhn","doi":"10.1039/d4na01012d","DOIUrl":"https://doi.org/10.1039/d4na01012d","url":null,"abstract":"<p><p>Spray drying is a well-established process for generating particles for various applications, including pharmaceuticals. In this process, atomization plays a crucial role by defining the size of the droplets and, consequently, particle size. While ultrasound is commonly used to enhance atomization by reducing droplet size, a novel approach has been introduced that utilizes plug flow to generate plugs resonating with an applied ultrasound frequency, triggering surface atomization. This study investigates the applicability of this method for microfluidic atomization and spray drying, particular for pharmaceutical carrier particles. The generated droplets exhibit a size of 7.24 μm and a PDI of 0.18, indicating a monodisperse distribution. The droplets are produced in discrete burst events, enabling an energy-efficient pulsed process with an applied power of less than 1 W. This approach successfully generates lipid nanoparticles with an average size of 140 nm, underscoring its potential for nanoparticle production.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11905916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexible nanoimprinted substrate integrating piezoelectric potential and photonic-plasmonic resonances.","authors":"Aeshah F Alotaibi, Rongcheng Gan, Eni Kume, Dominik Duleba, Ahmed Alanazi, Allan Finlay, Robert P Johnson, James H Rice","doi":"10.1039/d4na00942h","DOIUrl":"10.1039/d4na00942h","url":null,"abstract":"<p><p>Flexible substrates for sensing provide adaptable, lightweight, and highly sensitive platforms for detecting different substances. The flexibility of these substrates allows for seamless integration with complex shapes and dynamic surfaces, enabling monitoring in challenging conditions using methods such as surface-enhanced Raman spectroscopy (SERS). Here we outline a flexible metamaterial array sensor formed from plasmonic silver-coated nanoimprinted piezoelectric polyvinylidene fluoride film. We show that nanoscale array features can be prepared on the surface of the piezoelectric film using a facile nanoimprinting procedure. These nanoimprinted features act as polarization channels that enable plasmonic resonances, enhancing the SERS signal strength and improving reproducibility. We combine this effect with the inherent piezoelectric properties of polyvinylidene fluoride to further enhance the Raman signal strength upon mechanical deformation. Our results demonstrate a significant enhancement of the SERS signal when probed at a wavelength of 532 nm, achieving over an order of magnitude increase in signal strength for a range of analytes. This lightweight and flexible SERS substrate holds significant potential for applications in medical diagnostics, environmental monitoring, and trace detection, offering a highly sensitive and reproducible analytical platform.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chiral induction in the crystallization of KIO₃ and LiIO₃: the role of amino acids in controlling the chirality of inorganic crystals.","authors":"Matan Oliel, Yitzhak Mastai","doi":"10.1039/d4na01006j","DOIUrl":"10.1039/d4na01006j","url":null,"abstract":"<p><p>Chiral induction in crystals has attracted significant attention due to its implications for developing chiral materials and understanding mechanisms of symmetry-breaking enantioselective crystallization of naturally occurring chiral minerals. Despite its potential use in chiral discrimination, this area remains largely unexplored. Here, we investigate chiral induction during crystallization of naturally occurring chiral KIO₃ and LiIO₃ minerals using arginine and alanine as chiral inducers. The chiral nature of the crystallization and the effect of the chiral inducers were examined using circular dichroism, polarimetry, and low-frequency Raman spectroscopy. The impact of chiral molecules on the rate and final crystal structure was studied by electron microscopy including SEM and TEM. We demonstrate that it is possible to control the chirality with chiral exogenous molecules, mainly amino acids. Understanding chiral induction in crystal growth may open avenues for controlled assembly of chiral materials and development of novel functional materials with unique properties.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in RNAi-based nanoformulations: revolutionizing crop protection and stress tolerance in agriculture","authors":"Shivangi Mathur, Ambika Chaturvedi and Rajiv Ranjan","doi":"10.1039/D5NA00044K","DOIUrl":"10.1039/D5NA00044K","url":null,"abstract":"<p >Nucleic acid-based therapeutics have the ability to tackle a wide range of diseases and stress tolerance that present significant obstacles for conventional approaches in agriculture. RNA-based medicines have become a promising approach, using nanoformulation treatments to specifically target certain diseases. Nanoformulations offer numerous benefits in comparison to alternative treatment methods, such as precise administration, minimal toxicity, and medication loading compatibility due to their bioactivity. There are a variety of nanoformulations available today, such as liposomes, polymeric nanoparticles (NPs), magnetic NPs, nanogels, and solid lipid nanoparticles (SLNs). RNA-based therapy employs intracellular gene nanoparticles containing messenger RNA (mRNA), which play an important role in stress management and pest as well as disease control. The adoption of mRNA-based technology paves the way for future technological progress. This review focuses on elucidating the process underlying the development of RNA interference (RNAi) and the diverse array of nanocarriers employed for the transportation of RNAi. Currently, this technique is being employed in the field of crop protection to combat diseases, pests, and environmental stress. The article highlights the benefits of RNAi mediated nanoformulations and discusses the significant obstacles that must be overcome to improve the viability of this technology for future applications.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 7","pages":" 1768-1783"},"PeriodicalIF":4.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mangrove pneumatophores as biocatalysts for the fabrication of silver nanoparticles and their potential applications against biofilm formation and hepatic carcinoma.","authors":"Debasis Nayak, Awdhesh Kumar Mishra, Kunal Biswas, Asmita Sen, Chandana Malakar, Jibanjyoti Panda, Neelam Amit Kungwani, Sarvesh Rustagi, Bibhu Prasad Panda, Yugal Kishore Mohanta","doi":"10.1039/d4na00722k","DOIUrl":"10.1039/d4na00722k","url":null,"abstract":"<p><p>The current study demonstrates the biogenic synthesis of silver nanoparticles using the pneumatophores of <i>Acanthus ilicifolius</i> (AiP-AgNPs), which is cost-effective and biocompatible. <i>A. ilicifolius</i> possesses remarkable features to endure the harshest conditions for its entire life cycle and generates secondary metabolites for its sustainability in hostile mangrove ecosystems. The presence of a prominent UV-visible absorption band at 420 nm supported the distinct color change inference for the synthesized AiP-AgNPs. The size of the synthesized AiP-AgNPs was determined to be ∼15 nm through field emission-scanning electron microscopy (FE-SEM), transmission electron microscopy (cryo-TEM), and atomic force microscopy (AFM). The presence of secondary metabolites such as 2-bromo-1,1-dichloroethene, hemin and <i>N</i>-(sulfanylacetyl)-l-seryl-l-argininamide was indicated by prominent peaks in liquid chromatography, suggesting their probable roles in the synthesis of AgNPs. The synthesized AiP-AgNPs demonstrated a distinct zone of inhibition against <i>Pseudomonas aeruginosa</i> (15.33 mm), <i>Vibrio cholerae</i> (9.83 mm), and <i>Bacillus subtilis</i> (12 mm). They also exhibited concentration-dependent antioxidant activity in DPPH, nitric oxide, and hydrogen peroxide scavenging assays. The anticancer potential of the synthesized AiP-AgNPs against HepG2 hepatocarcinoma cells determined through MTT colorimetric assay and flow cytometry revealed their dose-dependent cytotoxicity with the occurrence of the sub-G₀ phase (25.6%). Subsequent analysis using fluorescence microscopy, DNA damage, comet assay, and migration assay indicated that AiP-AgNPs hold significant potential and the ability to serve as a therapeutic candidate to pave the way for further in-depth investigations for pre-clinical and clinical research purposes.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering a multivariate cobalt metal-organic framework for high photocatalytic activity: the impact of mixed ligands and metal incorporation in a visible light-driven heterogeneous photo-Fenton reaction for water treatment.","authors":"Noelia Rodríguez-Sánchez, Biswajit Bhattacharya, Franziska Emmerling, Carsten Prinz, Paula Prieto-Laria, A Rabdel Ruiz-Salvador, Menta Ballesteros","doi":"10.1039/d4na00954a","DOIUrl":"https://doi.org/10.1039/d4na00954a","url":null,"abstract":"<p><p>Metal-organic frameworks (MOFs) have attracted increasing attention for the removal of organic pollutants in wastewater <i>via</i> photocatalysis. Here, we design a multivariate modification of ZIF-9 to tune its electronic properties for use in visible light photocatalysis. A controllable synthesis of ZIF-9 and its multivariate forms with the incorporation of copper and the 2-imidazolecarboxaldehyde (ica) ligand was carried out. The materials are tested for the removal of the model dye methylene blue (MB) by a heterogeneous photo-Fenton-like reaction at neutral pH and room temperature. Cu-ZIF-9-ica (UPO-3) shows high photocatalytic activity under both visible and ultraviolet A (UVA) light, achieving 94% MB degradation in 45 min, compared to 65% MB degradation in 120 min using bare ZIF-9. The study revealed a first-order rate constant of 0.0475 min^-1 for Cu-ZIF-9-ica compared to 0.0088 min^-1 for ZIF-9 under visible light. The improvement of the catalyst was clearly attributed to the co-incorporation of Cu and the ica ligand in the MOF, which reduces the band gap, in agreement with DFT calculations. Reproducibility and recyclability tests proved that Cu-ZIF-9-ica can be used for at least 3 cycles without a significant loss of efficiency, making it a promising material for the study and application of wastewater treatment.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of carbon nanodots on the cellular redox reaction and immune system","authors":"Surabhi Verma, Manini Bhatt and Bodhisatwa Das","doi":"10.1039/D4NA00860J","DOIUrl":"10.1039/D4NA00860J","url":null,"abstract":"<p >Carbon nanodots are ultra-small carbonaceous nanostructures with excellent photoluminescence and cytocompatibility properties, making them suitable for developing excellent bioimaging probes. They exhibit dual properties, generating and scavenging reactive oxygen species, and are used as photosensitizers to produce reactive oxygen species under light and as photothermal agents that transform light energy into heat. This makes it possible to use them in photothermal and photodynamic therapies to treat cancer. They may enter the body by various means, including inhalation, ingestion, or intravenous injection. Once inside, they travel through the bloodstream, infiltrating tissues where they come into contact with the immune system, similar to infectious agents. These nanodots are identified by several receptors on the surface of innate immune cells, such as monocytes and macrophages, which attempt to engulf these nanodots. This interaction can induce a pro-inflammatory (M1) or anti-inflammatory (M2) response, modulating immune activity. This review explores the immuno-toxic potential of carbon nanodots, focusing on their ability to modulate redox balance by catalase, glutathione peroxidase, and superoxide dismutase, which are examples of antioxidant enzymes. Although carbon nanodots have demonstrated a wide range of applications, their effect on the cellular immune system remains largely unexplored. In this study, we primarily addressed the sophisticated impacts of carbon nanodots on the immune system and their diverse processes, such as the many cellular redox reactions implicated in antibacterial and antiviral treatment, wound healing, drug administration, and tumor therapy. As a result, we outline the benefits and difficulties of carbon nanodots in the biomedical domain and discuss their potential in the future development of clinical medicine.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 7","pages":" 1784-1802"},"PeriodicalIF":4.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucose reduced nano-Se mitigates Cu-induced ROS by upregulating antioxidant genes in zebrafish larvae.","authors":"Suganiya Umapathy, Ieshita Pan","doi":"10.1039/d4na00644e","DOIUrl":"10.1039/d4na00644e","url":null,"abstract":"<p><p>This study compares the therapeutic efficiency of bovine serum albumin-stabilized selenium nanoparticles in reducing oxidative stress and improving cellular health. The nanoparticles were synthesized using mussel-extracted selenium with two reducing agents: d-glucose and orange. Inductively coupled plasma-optical emission spectroscopy and X-ray diffraction analyses confirmed the presence of selenium. The reducing agent and duration influenced the nanoparticle size. Reduction with d-glucose for 1 hour revealed that the particles exhibited an average size of 10 nm. Copper sulfate-induced malformations such as yolk sac and pericardial edema were observed with 25 μg ml^-1 of orange-reduced nanoparticles, while d-glucose-reduced nanoparticles mitigated these malformations at 25 μg ml^-1. Treatment with stabilized Se-NPs reduced with d-glucose for 30 minutes showed 33% dose-dependent radical scavenging activities, upregulated approximately 2-fold of superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase encoding genes and restored homeostasis by decreasing lipid peroxidation (27.32 nmol mg^-1 ml^-1) and nitric oxide levels (6.71 μM). They also had the potential to restore cognitive properties such as larval movement (93.40 m) without altering larval behaviour. Live cell imaging indicated a significant decrease in cellular reactive oxygen species and lipid peroxidation levels in the gut and liver. These findings suggest that Se-NPs reduced for 30 minutes with d-glucose are promising candidates for oxidative stress-induced neurodegeneration.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High specific surface area MMT/NO₂ intercalated modified MgAl-LDH core-shell composites: effective inhibition for steel in Cl^- contaminated saturated Ca(OH)₂ solution.","authors":"Xiaoyi Zhang, Binxin Gan, Chen Wu, Guoliang Lin, Shenglan Ma, Yongbin Ye, Wanxi Jiang, Wenjin Huang","doi":"10.1039/d4na01011f","DOIUrl":"10.1039/d4na01011f","url":null,"abstract":"<p><p>This study developed nitrate-intercalated layered double hydroxides (NO₂-LDHs) and their core-shell composites (NO₂-LDHs@MMT) through an <i>in situ</i> co-precipitation method with montmorillonite (MMT). The corrosion inhibition performance for Q235 steel in simulated concrete pore solutions (saturated Ca(OH)₂ + 3.5 wt% NaCl) was systematically investigated. Comprehensive characterization <i>via</i> scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), high-resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and Fourier-transform infrared spectroscopy (FTIR) confirmed the successful construction of core-shell architecture and effective intercalation of nitrite anions between LDH layers. Nitrogen physisorption analysis revealed that the NO₂-LDHs@MMT composite possesses a specific surface area of 84.74 m² g^-1 with a pore volume of 0.284 cm³ g^-1, forming a hierarchical pore structure conducive to chloride ion entrapment. Electrochemical assessments including electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization demonstrated that both materials significantly improved the corrosion resistance of steel substrates, with NO₂-LDHs@MMT exhibiting superior performance (98.9% inhibition efficiency). The enhanced anticorrosion mechanism originates from: (1) the MMT core providing enlarged surface area for LDH growth, increasing active sites for Cl^- adsorption; (2) sustained release of NO₂ ^- from LDH galleries enabling stable passivation layer formation. These findings suggest that NO₂-LDHs@MMT composites hold promise as high-efficiency, durable corrosion inhibitors for steel reinforcement in chloride-contaminated alkaline environments.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the roles of pressure, oxidation state, and morphology in CO₂ electroreduction to C₂₊ gaseous products over copper oxides.","authors":"Asghar Ali, Ali S Alnaser","doi":"10.1039/d4na01019a","DOIUrl":"10.1039/d4na01019a","url":null,"abstract":"<p><p>This study provides compelling experimental evidence of the synergistic effects of reaction pressure, oxidation state, and catalyst morphology on the C₂₊ selectivity of copper (Cu) oxide catalysts in electrochemical CO₂ reduction (ECR). We employed femtosecond laser structuring and thermal treatments to synthesize Cu(0), Cu(i), Cu(ii), and a mixed oxidation state catalyst Cu(<i>x</i>) with characteristic micro- and nano-morphologies. The optimal CO₂ pressure for maximizing C₂₊ productivity in aqueous bicarbonate media was established by assessing the reaction products at different imposed pressures in a custom-designed, pressurizable two-compartment cell. Among Cu(0), Cu(i), and Cu(ii), thermally produced Cu(i) was the only unstructured catalyst exhibiting ethylene gas-phase selectivity. Nanostructuring enhanced the C₂₊ selectivity such that all three oxidation states could produce ethylene. More importantly, the nanostructured Cu(<i>x</i>) comprising well-dispersed Cu(0), Cu(i), and Cu(ii), exhibited ethylene as well as ethane production - a characteristic associated with the synergistic effects of undercoordinated Cu states in stabilizing reaction intermediates and facilitating charge transfer to yield longer C₂₊ products. This work provides important insights into the key factors influencing C₂₊ selectivity in Cu-based catalysts, establishing the basis for an informed design to yield high-energy density products.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}