Nanoscale Advances最新文献

{"title":"Biosynthesized iron oxide-nanoparticle encapsulated hydrogel functionalized with platelet-rich plasma (PRP) accelerates wound healing in an animal model.","authors":"Lipsa Leena Panigrahi, Siddharth Satpathy, Pallavi Samal, Shashank Shekhar, Shakti Ketan Prusty, Manoranjan Arakha","doi":"10.1039/d5na00621j","DOIUrl":"10.1039/d5na00621j","url":null,"abstract":"<p><p>Wound healing is rendered less effective mainly due to exudate overload, bacterial growth, and limited growth factors in most cases, resulting in delayed wound healing and complications. This study reveals a new class of smart wound-healing hydrogels encapsulated with biosynthesized iron oxide nanoparticles for accelerated antimicrobial activity and wound healing. Screening these organic hybrid hydrogels revealed promising wound healing and antimicrobial properties by controlled protein secretion from the hydrogel containing PRP, alongside the mitigation of infection due to the bacteria. The hydrogel antimicrobial activity was boosted <i>via</i> green-synthesized IONP incorporation, illustrating more pronounced killing in Gram-negative bacteria, which is highly consistent with TEM-morphological alterations in the bacteria's structure, cell wall, and membrane. The chitosan-based hydrogel exhibited the lowest half-maximal scavenging concentration. The hydrogels also exhibited high cell viability and growth. Further investigation into the wound healing activity of the hydrogel was conducted using an animal model, which showed healing in 18 days compared to the control and standard. Overall, this study demonstrates a feasible design for tailoring new surface-functionalized organic-inorganic hybrid hydrogels as promising antimicrobial and wound healing agents.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the chemical analysis of nitrite in environmental and biological samples","authors":"Nadeen Rajab, Hosny Ibrahim, Daohong Zhang, Ahmed F. A. Youssef and Rabeay Y. A. Hassan","doi":"10.1039/D5NA00503E","DOIUrl":"10.1039/D5NA00503E","url":null,"abstract":"<p >Nitrite, a potential environmental pollutant, poses a significant threat to human health. Thus, accurate and sensitive detection methods are essential for effective continuous monitoring and surveillance. In this regard, a wide range of instrumental methods for the precise determination of nitrite in different types of complex samples is collected and discussed. Besides the classical methods, chromatographic and spectroscopic techniques are included. Although these methods exhibit high sensitivity and selectivity, they involve high cost and complicated operating protocols, and warrant high caution in sample preparations. Other reported techniques, such as electrochemical and bio-electrochemical methods, could offer onsite detection and disposability, and involve handheld devices. Such features are required for simple optimization, field applicability for analysis of a large number of samples, fast response, simple device calibration, and validation. Thus, nanostructure-based electrochemical approaches are widely developed and applied in the analysis of target analytes in complex biological and environmental matrices using a few microlitres of the samples, without any prior sample preparation. Therefore, to consider the global market's needs, challenges, and perspectives on each reported method for nitrite, a comprehensive discussion has been included in this review.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 20","pages":" 6321-6372"},"PeriodicalIF":4.6,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A stepwise responsive Au-SS-PEG/Sor/ATP_aptamer/LHRH-MPG^ΔNLS drug delivery vector system for overcoming drug resistance in immunotherapy of hepatocellular carcinoma.","authors":"Mengting Tong, Guangpeng Chen, Yong Dong, Yubin Pan, Yanan Xue, Da Li","doi":"10.1039/d5na00056d","DOIUrl":"10.1039/d5na00056d","url":null,"abstract":"<p><p>Despite the progress made in novel immunotherapy for hepatocellular carcinoma (HCC), drug resistance remains a challenging problem. In this study, we developed a stepwise nanodrug delivery system, known as Au-SS-PEG/Sor/ATP_aptamer/LHRH-MPG^ΔNLS, to adapt to the high concentrations of glutathione (GSH) and adenine nucleoside triphosphate/adenosines (ATP/ADO) found in cancer cells and the tumor microenvironment (TME). This system utilizes novel Au nanoclusters conjugated with disulfide-linked PEG as vectors to transport sorafenib (Sor) and an ATP-binding nucleic acid aptamer (ATP_apt). It can enter HCC cells through luteinizing hormone-releasing hormone (LHRH)-MPG^ΔNLS (LM). Within the cells, the disulfide bonds of the nanoclusters are cleaved by the high levels of GSH, leading to the release of Sor/ATPapt. This release can be further triggered by ATP/ADO, resulting in a stepwise drug release mechanism. Furthermore, this nanodrug system has exhibited the ability to overcome αPD-1 resistance in HCC tumors. In summary, our novel drug delivery system demonstrates a dramatic anti-HCC effect and holds great potential for treating HCC patients.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered riboflavin-cerium oxide nanoparticles for enhanced phototoxicity toward triple-negative breast cancer cells.","authors":"Anongnat Wongpan, Sopon Nuchpun, Napasorn Tana-Atsawapon, Patraporn Luksirikul, Sarisa Suriyarak, Jintana Artsanthia, Kanlaya Prapainop Katewongsa","doi":"10.1039/d5na00555h","DOIUrl":"10.1039/d5na00555h","url":null,"abstract":"<p><p>Cerium oxide nanoparticles (CeO₂ NPs) are redox-active nanomaterials with promising applications in biomedical engineering. In this study, CeO₂ NPs are functionalized with riboflavin to enhance cellular uptake and introduce photoresponsive properties. <i>In vitro</i> studies demonstrate that the resulting riboflavin-modified CeO₂ (Rf-CeO₂) NPs exhibit low toxicity under dark conditions but exert significantly enhanced cytotoxicity against triple-negative breast cancer (TNBC) MDA-MB-231 cells upon ultraviolet (UV) irradiation. This light-triggered cytotoxic effect is attributed to the photoactive nature of riboflavin, which alters reactive oxygen species (ROS) generation upon UV exposure. Our findings highlight the potential of Rf-CeO₂ NPs as a selectively light-activated nanoplatform for targeted cancer therapy that integrates redox functionality and photoactivity into a single engineered nanomaterial, particularly for TNBC and other aggressive cancer subtypes.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12481217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying surface groups on aminated silica nanoparticles of different size, surface chemistry, and porosity with solution NMR, XPS, optical assays, and potentiometric titration.","authors":"Isabella Tavernaro, Isabelle Rajotte, Marie-Pier Thibeault, Philipp C Sander, Oltion Kodra, Gregory Lopinski, Jörg Radnik, Linda J Johnston, Andreas Brinkmann, Ute Resch-Genger","doi":"10.1039/d5na00794a","DOIUrl":"10.1039/d5na00794a","url":null,"abstract":"<p><p>We assessed the quantification of surface amino functional groups (FGs) for a large set of commercial and custom-made aminated silica nanoparticles (SiO₂ NPs) with sizes of 20-100 nm, prepared with different sol-gel routes, different amounts of surface amino FGs, and different porosity with four methods providing different, yet connected measurands in a bilateral study of two laboratories, BAM and NRC, with the overall aim to develop standardizable measurements for surface FG quantification. Special emphasis was dedicated to traceable quantitative magnetic resonance spectroscopy (qNMR) performed with dissolved SiO₂ NPs. For the cost efficient and automatable screening of the amount of surface amino FGs done in a first step of this study, the optical fluorescamine assay and a potentiometric titration method were utilized by one partner, <i>i.e.</i>, BAM, yielding the amount of primary amino FGs accessible for the reaction with a dye precursor and the total amount of (de)protonatable FGs. These measurements, which give estimates of the minimum and maximum number of surface amino FGs, laid the basis for quantifying the amount of amino silane molecules with chemo-selective qNMR with stepwise fine-tuned workflows, involving centrifugation, drying, weighting, dissolution, measurement, and data evaluation steps jointly performed by BAM and NRC. Data comparability and relative standard deviations (RSDs) obtained by both labs were used as quality measures for method optimization and as prerequisites to identify method-inherent limitations to be later considered for standardized measurement protocols. Additionally, the nitrogen (N) to silicon (Si) ratio in the near-surface region of the SiO₂ NPs was determined by both labs using X-ray photoelectron spectroscopy (XPS), a well established surface sensitive analytical method increasingly utilized for microparticles and nano-objects which is currently also in the focus of international standardization activities. Overall, our results underline the importance of multi-method characterization studies for quantifying FGs on NMs involving at least two expert laboratories for effectively identifying sources of uncertainty, validating analytical methods, and deriving NM structure-property relationships.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heavy boron doping effects on biaxially tensile strained germanium (>1.5%) investigated <i>via</i> structural characterization, effective lifetime assessment and atomistic modeling.","authors":"Shuvodip Bhattacharya, Steven W Johnston, Mantu K Hudait","doi":"10.1039/d5na00414d","DOIUrl":"10.1039/d5na00414d","url":null,"abstract":"<p><p>Highly tensile strained germanium (ε-Ge) represents an essential material system for emerging electronic and photonics applications. Moreover, adjusting the doping levels to moderate or high concentrations can effectively tailor the properties of ε-Ge for specific applications. This article combines experimental characterization with a theoretical framework to examine the effects of heavy elemental boron (B) doping on pseudomorphic sub-50 nm ε-Ge. High resolution X-ray diffractometry is used to validate tensile strain levels of 1.53% and 1.68% in Ge epilayers, surpassing the indirect-to-direct band gap crossover point at ∼1.5% biaxial tensile strain. Cross-sectional transmission electron microscopy revealed visual evidence of stacking faults and surface roughening in 1.68% ε-Ge, although a coherent and abrupt Ge/III-V heterointerface is observed, devoid of interfacial misfit dislocations. Effective lifetime measurements demonstrated approximately twofold enhancement in 1.53% B-doped ε-Ge (<i>N</i> _B ∼7 × 10¹⁹ cm^-3) compared to its unstrained B-doped counterpart, while no such improvement was observed in 1.68% B-doped ε-Ge. This lack of enhancement is attributed to the presence of stacking faults and surface roughness within the ε-Ge epilayer. Through density functional theory calculations, we independently demonstrate that substitutional B atoms induce local deformation of Ge-Ge bonds in both unstrained Ge and ε-Ge epilayers, resulting in an additive tensile strain. This phenomenon could potentially lead to dynamic reduction and overcoming of the critical layer thickness for the system, facilitating the nucleation and subsequent glide of 90° leading Shockley partial dislocations, thereby generating stacking faults. In essence, these findings establish an upper limit on the B-doping concentration that can be achieved in highly ε-Ge epilayers, and collectively, offer valuable insights into the significance of heavy doping in Ge-based heterostructures. As such, this study delineates a fundamental constraint for integrating heavily doped ε-Ge in high-performance optoelectronic systems, necessitating precise strain-doping co-optimization to avoid performance degradation.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12447295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hierarchically porous RhB-encapsulated ZIF-7 as a dual-emission fluorescence probe for ultrasensitive detection of melamine in infant formulations.","authors":"Sreevidhya K B, Suvardhan Kanchi","doi":"10.1039/d5na00633c","DOIUrl":"10.1039/d5na00633c","url":null,"abstract":"<p><p>Melamine is an unauthorized food additive and a highly concerning adulterant in foods that can occur either accidently or intentionally in dairy products, with potential health risks upon exposure to higher concentrations. An ultrasensitive fluorescent probe based on dual emissive RhB _<i>x</i> @ZIF-7 was developed to detect melamine. In this study, a fluorescent dye, Rhodamine B (RhB), was successfully encapsulated into the metal-organic framework (MOF) pores of ZIF-7 to form a fluorescent probe (RhB₃₀@ZIF-7), with dual emission properties to enable the detection of melamine at low concentrations. RhB₃₀@ZIF-7 was optimized by varying experimental parameters, including temperature (25 °C), pH (7.0), incubation time (10 min), and probe concentration (1 mg mL^-1), to enhance its sensitivity and selectivity. The observed fluorescent quenching towards melamine was primarily attributed to the mechanisms of the internal filtering effect (IFE), due to absorption of the excitation wavelength by melamine, causing a turn-off response in the system. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.47 μM and 1.4 μM, respectively, with an <i>R</i> ² of 0.99. This study reveals the previously unexplored enhanced fluorescence of RhB₃₀@ZIF-7 and elucidates the contribution of the intermolecular interaction between RhB and ZIF-7 to fluorescence sensing, paving the way for food safety monitoring.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical phonon confinement significantly lowers the hot electron energy loss rate in III-nitride (InN, GaN, and AlN) and GaAs nanoscale structures","authors":"Huynh Thi Phuong Thuy and Nguyen Dinh Hien","doi":"10.1039/D5NA00483G","DOIUrl":"10.1039/D5NA00483G","url":null,"abstract":"<p >This investigation presents a detailed comparative analysis of the energy loss rate (ELR) in the III-nitride (InN, AlN, and GaN) and GaAs quantum well (QW) heterostructures of hot electrons because of confined and bulk optical phonon (OP) scattering based on the electronic temperature model. This analysis is conducted because of the impact of a quantizing magnetic field and utilizes the framework of OP confinement proposed by Huang and Zhu. The following results are what we have obtained: firstly, the explicit expression of the average ELR in the III-nitride (InN, AlN, and GaN) and GaAs QW heterostructures of hot electrons because of confined OP interaction. Secondly, the graphs describe the dependencies of the ELR in the InN, GaN, and AlN, and GaAs QW heterostructures of hot electrons on the quantizing magnetic field, two-dimensional electronic concentration, temperature of the two-dimensional electrons, and QW heterostructure width for both the aforementioned OP types. Thirdly, the comparative graphs of the above dependencies between the InN, AlN, and GaN, and GaAs material QW heterostructures in all three cases of OPs, including bulk, confinement, and both bulk and confinement are presented. Finally, the various contributions from individual phonon modes to the ELR in the III-nitride (InN, AlN, and GaN) and GaAs QW heterostructures of hot electrons are analyzed. Our research offers insightful knowledge that will support the development and manufacturing of optoelectronic devices.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 20","pages":" 6620-6639"},"PeriodicalIF":4.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scalable synthesis and optical tuning of CsPbBr3 nanocrystal inks for dual-color anti-counterfeiting applications","authors":"Tianming Sun†, Yining Zhao, Yujia Fan, Xiaoyu Guo, Zhexin Tang and Mingqing Wang","doi":"10.1039/D5NA00602C","DOIUrl":"10.1039/D5NA00602C","url":null,"abstract":"<p >We present a scalable, ambient-air synthesis of CsPbBr<small>₃</small> perovskite nanocrystal (NC) inks with enhanced optical performance and environmental stability, enabled by post-synthetic surface modification using oleylamine (OAm). Systematic tuning of OAm concentration led to NCs with reduced particle size, improved crystallinity, and effective defect passivation, yielding a peak photoluminescence quantum yield (PLQY) of 93.1% and a prolonged carrier lifetime of 84.02 ns. These modified NCs exhibited significantly improved long-term structural stability compared to unmodified samples. Furthermore, halide exchange <em>via</em> iodine incorporation enabled controlled emission tuning from green to red. Dual-color emissive inks were digitally printed into high-resolution patterns on flexible substrates, which remained inconspicuous under visible light but displayed vivid fluorescence under UV illumination. This dual-mode visibility offers a secure and versatile platform for next-generation anti-counterfeiting technologies and information encryption, demonstrating the potential of perovskite NCs in advanced functional ink applications.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 20","pages":" 6422-6425"},"PeriodicalIF":4.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic selenium vacancies and bismuth metal centers on Bi2Se3 for enhanced photocatalytic CO2 reduction","authors":"Yanjun Zhu, Qiutong Han and Yong Zhou","doi":"10.1039/D5NA00526D","DOIUrl":"10.1039/D5NA00526D","url":null,"abstract":"<p >Ultrathin inorganic nanosheets possess a novel electronic structure that enables exceptional performance in the catalytic reduction of carbon dioxide (CO<small>₂</small>), representing a promising strategy to mitigate global warming. Bismuth selenide (Bi<small>₂</small>Se<small>₃</small>) nanosheets are important topological insulators exhibiting high electrical conductivity. Through a solvothermal method followed by hydrogen annealing, selenium-vacancy-rich Bi<small>₂</small>Se<small>₃</small> nanosheets with <em>in situ</em> formed bismuth metal clusters are prepared. In this system, surface Se vacancies function as active centers for electron trapping and CO<small>₂</small> adsorption, while Bi metal clusters serve as reactive sites to facilitate charge transfer and catalytic reactions. This dual-functional design establishes a unidirectional electron transfer pathway from selenium vacancies to Bi metal through the topological conductive surface, thereby concentrating electrons at the Bi interface and providing abundant reducing equivalents to enhance CO yield.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 20","pages":" 6640-6645"},"PeriodicalIF":4.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}