Engineered riboflavin-cerium oxide nanoparticles for enhanced phototoxicity toward triple-negative breast cancer cells.

IF 4.6 3区材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Nanoscale Advances Pub Date : 2025-09-10 DOI:10.1039/d5na00555h

Anongnat Wongpan, Sopon Nuchpun, Napasorn Tana-Atsawapon, Patraporn Luksirikul, Sarisa Suriyarak, Jintana Artsanthia, Kanlaya Prapainop Katewongsa

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Abstract

Cerium oxide nanoparticles (CeO₂ NPs) are redox-active nanomaterials with promising applications in biomedical engineering. In this study, CeO₂ NPs are functionalized with riboflavin to enhance cellular uptake and introduce photoresponsive properties. In vitro studies demonstrate that the resulting riboflavin-modified CeO₂ (Rf-CeO₂) NPs exhibit low toxicity under dark conditions but exert significantly enhanced cytotoxicity against triple-negative breast cancer (TNBC) MDA-MB-231 cells upon ultraviolet (UV) irradiation. This light-triggered cytotoxic effect is attributed to the photoactive nature of riboflavin, which alters reactive oxygen species (ROS) generation upon UV exposure. Our findings highlight the potential of Rf-CeO₂ NPs as a selectively light-activated nanoplatform for targeted cancer therapy that integrates redox functionality and photoactivity into a single engineered nanomaterial, particularly for TNBC and other aggressive cancer subtypes.

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工程核黄素-氧化铈纳米颗粒增强对三阴性乳腺癌细胞的光毒性。

氧化铈纳米颗粒（CeO2 NPs）是一种具有氧化还原活性的纳米材料，在生物医学工程中具有广阔的应用前景。在这项研究中，CeO2 NPs被核黄素功能化，以增强细胞摄取并引入光响应特性。体外研究表明，核黄素修饰的CeO2 (Rf-CeO2) NPs在黑暗条件下表现出低毒性，但在紫外线（UV）照射下对三阴性乳腺癌（TNBC） MDA-MB-231细胞具有显著增强的细胞毒性。这种光触发的细胞毒性作用归因于核黄素的光活性，核黄素在紫外线照射下改变活性氧（ROS）的产生。我们的研究结果突出了Rf-CeO2 NPs作为靶向癌症治疗的选择性光激活纳米平台的潜力，该平台将氧化还原功能和光活性整合到单个工程纳米材料中，特别是对于TNBC和其他侵袭性癌症亚型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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