Nanoscale Advances最新文献_第10页

A tilapia skin-derived gelatin hydrogel combined with the adipose-derived stromal vascular fraction for full-thickness wound healing† 罗非鱼皮衍生明胶水凝胶与脂肪衍生基质血管部分相结合，用于全厚伤口愈合

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2024-07-08 DOI: 10.1039/D4NA00332B

Yanan Luo, Manfei Fu, Ziyi Zhou, Xiaopei Zhang, Qingxia Guo, Yawen Wang, Weina Zhang, Yuanfei Wang, Zhenyu Chen and Tong Wu

{"title":"A tilapia skin-derived gelatin hydrogel combined with the adipose-derived stromal vascular fraction for full-thickness wound healing†","authors":"Yanan Luo, Manfei Fu, Ziyi Zhou, Xiaopei Zhang, Qingxia Guo, Yawen Wang, Weina Zhang, Yuanfei Wang, Zhenyu Chen and Tong Wu","doi":"10.1039/D4NA00332B","DOIUrl":"10.1039/D4NA00332B","url":null,"abstract":"Biomaterials are widely used in regenerative medicine to repair full-thickness skin defect wounds. The adipose-derived stromal vascular fraction (SVF) shows pro-regenerative properties, however, the ex vivo biological activity of SVF is suppressed due to the lack of an external scaffold. Tilapia skin, as a sustained and recyclable biomaterial with low immunogenicity, was applied in the preparation of a hydrogel. The mixture of tilapia skin-derived gelatin and methacrylic anhydride as a scaffold facilitated the paracrine function of SVF and exerted a synergistic effect with SVF to promote wound healing. In this study, 30% (w/v) SVF was added to methacrylate-functionalized tilapia skin gelatin and subsequently exposed to UV irradiation to form a three-dimensional nano-scaffolding composite hydrogel (FG-SVF-3). The effects of paracrine growth factors, neovascularization, and collagen production on wound healing were extensively discussed. FG-SVF-3 displayed a pronounced wound healing ability via in vivo wound models. The FG-SVF-3 hydrogel enhanced the biocompatibility and the expression of EGF, bFGF, and VEGF. FG-SVF-3, as a promising wound dressing, exhibited superior ability to accelerate wound healing, skin regeneration, and wound closure.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/na/d4na00332b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141571632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mn-ferrite nanoparticles as promising magnetic tags for radiofrequency inductive detection and quantification in lateral flow assays† 锰铁氧体纳米粒子有望成为侧流检测中射频感应检测和定量的磁性标签

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2024-07-08 DOI: 10.1039/D4NA00445K

Vanessa Pilati, María Salvador, Leyre Bei Fraile, José Luis Marqués-Fernández, Franciscarlos Gomes da Silva, Mona Fadel, Ricardo López Antón, María del Puerto Morales, José Carlos Martinez-García and Montserrat Rivas

{"title":"Mn-ferrite nanoparticles as promising magnetic tags for radiofrequency inductive detection and quantification in lateral flow assays†","authors":"Vanessa Pilati, María Salvador, Leyre Bei Fraile, José Luis Marqués-Fernández, Franciscarlos Gomes da Silva, Mona Fadel, Ricardo López Antón, María del Puerto Morales, José Carlos Martinez-García and Montserrat Rivas","doi":"10.1039/D4NA00445K","DOIUrl":"10.1039/D4NA00445K","url":null,"abstract":"Lateral flow assays are low-cost point-of-care devices that are stable, easy to use, and provide quick results. They are mostly used as qualitative screening tests to detect biomarkers for several diseases. Quantification of the biomarkers is sometimes desirable but challenging to achieve. Magnetic nanoparticles can be used as tags, providing both visual and magnetic signals that can be detected and quantified by magnetic sensors. In the present work, we synthesized superparamagnetic MnFe2O4 nanoparticles using the hydrothermal coprecipitation route. MnFe2O4 presents low magnetic anisotropy and high saturation magnetization, resulting in larger initial magnetic susceptibility, which is crucial for optimizing the signal in inductive sensors. We functionalized the coprecipitated nanoparticles with citric acid to achieve colloidal stability in a neutral pH and to provide carboxyl groups to their surface to bioconjugate with biomolecules, such as proteins and antibodies. The nanomaterials were characterized by several techniques, and we correlated their magnetic properties with their sensitivity and resolution for magnetic detection in radiofrequency inductive sensors. We considered the NeutrAvidin/biotin model of biorecognition to explore their potential as magnetic labels in lateral flow assays. Our results show that MnFe2O4 nanoparticles are more sensitive to inductive detection than magnetite nanoparticles, the most used nanotags in magnetic lateral flow assays. These nanoparticles present high potential as magnetic tags for the development of sensitive lateral flow immunoassays for detecting and quantifying biomarkers.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/na/d4na00445k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141571637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coalescence behavior of size-selected gold and tantalum nanoclusters under electron beam irradiation: insights into nano-welding mechanisms 电子束辐照下尺寸精选的金和钽纳米团簇的凝聚行为：纳米焊接机制的启示

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2024-07-08 DOI: 10.1039/D4NA00373J

Shengyong Hu, Syed Adil Shah, Syed Niaz Ali Shah, Zixiang Zhao, Wuwen Zhu, Yongxin Zhang, Siqi Lu, Sichen Tang, Kuo-Juei Hu and Fengqi Song

{"title":"Coalescence behavior of size-selected gold and tantalum nanoclusters under electron beam irradiation: insights into nano-welding mechanisms","authors":"Shengyong Hu, Syed Adil Shah, Syed Niaz Ali Shah, Zixiang Zhao, Wuwen Zhu, Yongxin Zhang, Siqi Lu, Sichen Tang, Kuo-Juei Hu and Fengqi Song","doi":"10.1039/D4NA00373J","DOIUrl":"10.1039/D4NA00373J","url":null,"abstract":"The emerging technique of nano-welding (NW) via precisely regulating the fusion of nanoclusters (NCs) in nanotechnology has attracted significant attention for its innovative approach. Employing the gas-phase condensation cluster source with a lateral time-of-flight (TOF) mass-selector, size-selected gold (Au), and tantalum (Ta) NCs were prepared. This study explores the coalescence behavior of size-selected Au and Ta NCs under electron beam irradiation, aiming to investigate the related mechanism governing the welding process. Intrinsically driven by the reduction of excess surface energy, electron beam induces atomic thermal migration, fostering sintering neck growth at cluster interfaces. During this process, atomic diffusion and recrystallization enable NCs to alter shape while retaining stable facet planes. Aberration-corrected scanning transmission electron microscopy (AC-STEM) showcases the formation of single or polycrystalline sintered clusters, during which some lattice distortions can be eliminated. Interestingly, oxidized Ta clusters experience knock-on damage caused by elastic scattering of electron beams, partially deoxidizing them. Additionally, electron–phonon inelastic scattering transforms oxidized Ta clusters from amorphous to crystalline structures. Moreover, the quantum size effect and surface effect of NCs facilitate the surpassing of miscibility limits during Au–Ta heterogeneous welding processes. This investigation bridges the gap between fundamental research on cluster materials and their practical applications.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/na/d4na00373j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141571635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In situ investigation of ruthenium doped lanthanum nickel titanium double perovskite and its exsolution behaviour† 原位研究掺钌镧镍钛双包晶及其溶出行为

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2024-07-08 DOI: 10.1039/D4NA00349G

Jia Guo, Andrey Berenov and Stephen J. Skinner

{"title":"In situ investigation of ruthenium doped lanthanum nickel titanium double perovskite and its exsolution behaviour†","authors":"Jia Guo, Andrey Berenov and Stephen J. Skinner","doi":"10.1039/D4NA00349G","DOIUrl":"10.1039/D4NA00349G","url":null,"abstract":"Exsolution, an innovative method for fabricating perovskite-based oxides decorated with metal nanoparticles, has garnered significant interest in the fields of catalyst fabrication and electrochemical devices. Although dopant exsolution from single perovskite structures has been extensively studied, the exsolution behaviour of double perovskite structures remains insufficiently understood. In this study, we synthesized B-site double perovskite Ru-doped lanthanum nickel titanates with a 7.5 at% A-site deficiency, and systematically investigated the exsolution process that formed nickel metal nanoparticles on the material surface, across a broad reduction temperature range of 350–1000 °C. Both Ex situ and in situ characterization revealed that small, uniform Ni nanoparticles exsolved at low temperatures, whereas the exsolution of ruthenium required higher reduction temperatures beyond 1000 °C. Within the reduction temperature range of 350–500 °C, a notable finding is the reconstruction of exsolved nanoparticles, implying that Ni particles exist in a thermodynamically metastable state. Electrochemical impedance spectroscopy (EIS) showed a decreased area specific resistance (ASR) during the progress of exsolution. The increase in current density of a full solid oxide cell (SOC) in electrolysis mode and the doubling of peak power density in fuel cell mode attributed to the exsolution of Ni nanoparticles highlight the potential application of metal exsolution in electrode materials for SOCs.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/na/d4na00349g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141571636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Controlled synthesis, properties, and applications of ultralong carbon nanotubes 超长碳纳米管的可控合成、特性和应用

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2024-07-05 DOI: 10.1039/D4NA00437J

Kangkang Wang, Fei Wang, Qinyuan Jiang, Ping Zhu, Khaixien Leu and Rufan Zhang

{"title":"Controlled synthesis, properties, and applications of ultralong carbon nanotubes","authors":"Kangkang Wang, Fei Wang, Qinyuan Jiang, Ping Zhu, Khaixien Leu and Rufan Zhang","doi":"10.1039/D4NA00437J","DOIUrl":"10.1039/D4NA00437J","url":null,"abstract":"Carbon nanotubes (CNTs) are typical one-dimensional nanomaterials which have been widely studied for more than three decades since 1991 because of their excellent mechanical, electrical, thermal, and optical properties. Among various types of CNTs, the ultralong CNTs which have lengths over centimeters and defect-free structures exhibit superior advantages for fabricating superstrong CNT fibers, CNT-based chips, transparent conductive films, and high-performance cables. The length, orientation, alignment, defects, cleanliness, and other microscopic characteristics of CNTs have significant impacts on their fundamental physical properties. Therefore, the controlled synthesis and mass production of high-quality ultralong CNTs is the key to fully exploiting their extraordinary properties. Despite significant progress made in the study of ultralong CNTs during the past three decades, the precise structural control and mass production of ultralong CNTs remain a great challenge. In this review, we systematically summarize the growth mechanism and controlled synthesis strategies of ultralong CNTs. We also introduce the progress in the applications of ultralong CNTs. Additionally, we summarize the scientific and technological challenges facing the mass production of ultralong CNTs and provide an outlook and in-depth discussion on the future development direction.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/na/d4na00437j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyimide as a biomedical material: advantages and applications 作为生物医学材料的聚酰亚胺：优势与应用

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2024-07-04 DOI: 10.1039/D4NA00292J

Junjie Shu, Zhongfu Zhou, Huaping Liang and Xia Yang

{"title":"Polyimide as a biomedical material: advantages and applications","authors":"Junjie Shu, Zhongfu Zhou, Huaping Liang and Xia Yang","doi":"10.1039/D4NA00292J","DOIUrl":"10.1039/D4NA00292J","url":null,"abstract":"Polyimides (PIs) are a class of polymers characterized by strong covalent bonds, which offer the advantages of high thermal weight, low weight, good electronic properties and superior mechanical properties. They have been successfully used in the fields of microelectronics, aerospace engineering, nanomaterials, lasers, energy storage and painting. Their biomedical applications have attracted extensive attention, and they have been explored for use as an implantable, detectable, and antibacterial material in recent years. This article summarizes the progress of PI in terms of three aspects: synthesis, properties, and application. First, the synthetic strategies of PI are summarized. Next, the properties of PI as a biological or medical material are analyzed. Finally, the applications of PI in electrodes, biosensors, drug delivery systems, bone tissue replacements, face masks or respirators, and antibacterial materials are discussed. This review provides a comprehensive understanding of the latest progress in PI, thereby providing a basis for developing new potentially promising materials for medical applications.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/na/d4na00292j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141547572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiplexed immunolabelling of cancer using bioconjugated plasmonic gold–silver alloy nanoparticles† 利用生物共轭等离子金银合金纳米粒子对癌症进行多重免疫标记

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2024-07-03 DOI: 10.1039/D4NA00052H

Cécile Darviot, Bryan Gosselin, Flavie Martin, Sergiy Patskovsky, Ivan Jabin, Gilles Bruylants, Dominique Trudel and Michel Meunier

{"title":"Multiplexed immunolabelling of cancer using bioconjugated plasmonic gold–silver alloy nanoparticles†","authors":"Cécile Darviot, Bryan Gosselin, Flavie Martin, Sergiy Patskovsky, Ivan Jabin, Gilles Bruylants, Dominique Trudel and Michel Meunier","doi":"10.1039/D4NA00052H","DOIUrl":"10.1039/D4NA00052H","url":null,"abstract":"Reliable protein detection methods are vital for advancing biological research and medical diagnostics. While immunohistochemistry and immunofluorescence are commonly employed, their limitations underscore the necessity for alternative approaches. This study introduces immunoplasmonic labelling, utilizing plasmonic nanoparticles (NPs), specifically designed gold and gold–silver alloy NPs (Au:Ag NPs), for multiplexed and quantitative protein detection. These NPs, when coupled with antibodies targeting proteins of interest, enable accurate counting and evaluation of protein expression levels while overcoming issues such as autofluorescence. In this study, we compare two nanoparticle functionalization strategies—one coating based on thiolated PEG and one coating based on calix[4]arenes—on gold and gold–silver alloy nanoparticles of varying sizes. Overall results tend to demonstrate a greater versatility for the calix[4]arene-based coating. With this coating and using the classical EDC/sulfo-NHS cross-linking procedure, we also demonstrate the successful multiplexed immunolabelling of Her2, CD44, and EpCAM in breast cancer cell lines (SK-BR-3 and MDA-MB-231). Furthermore, we introduce a user-friendly software for automatic NP detection and classification by colour, providing a promising proof-of-concept for the practical application of immunoplasmonic techniques in the quantitative analysis of biopsies in the clinical setting.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/na/d4na00052h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141518925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nickel coating on plasmonic copper nanoparticles lowers cytotoxicity and enables colorimetric pH readout for antibacterial wound dressing application† 等离子体纳米铜粒子上的镍涂层降低了细胞毒性，并实现了抗菌伤口敷料应用中的比色 pH 值读取功能

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2024-07-02 DOI: 10.1039/D4NA00244J

Bohan Zhang, Sladjana Slavkovic, Yumin Qiu, Chun Peng and Jennifer I-Ling Chen

{"title":"Nickel coating on plasmonic copper nanoparticles lowers cytotoxicity and enables colorimetric pH readout for antibacterial wound dressing application†","authors":"Bohan Zhang, Sladjana Slavkovic, Yumin Qiu, Chun Peng and Jennifer I-Ling Chen","doi":"10.1039/D4NA00244J","DOIUrl":"10.1039/D4NA00244J","url":null,"abstract":"Wound infection poses a significant challenge to the natural healing process. It can impede various stages of wound healing, thereby hindering tissue regeneration and increasing the risk of systemic complications. Wound dressings emerged as a crucial option in the management of infections. Herein, we investigate fabrics coated with copper-based nanoparticles for potential wound dressing application. We synthesized copper and copper–nickel (Cu–Ni) core–shell nanoparticles via a polyol synthesis and investigated their particle growth dynamics and chemical stability. The nickel coating stabilized the nanoparticles against oxidation and dissolution, while dampening the localized surface plasmon resonance of copper. When coated on the fabrics, we found that Cu–Ni NPs were slightly less effective as an antibacterial agent than Cu NPs, however the cytotoxicity of Cu–Ni NPs was significantly reduced compared to pure Cu. Additionally, we show that the discoloration of nanoparticle-coated fabrics depended on pH, thus enabling the visualization of pH levels of simulated wound fluids which can provide information on the inflammatory state of the wound. Our work contributes to the understanding of copper-based nanoparticles and their potential applications in healthcare.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/na/d4na00244j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the impact of different liposomal formulations on the plasma protein corona composition might give hints on the targeting capability of nanoparticles† 揭示不同脂质体配方对血浆蛋白电晕成分的影响可能有助于了解纳米粒子的靶向能力

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2024-07-02 DOI: 10.1039/D4NA00345D

Esther Imperlini, Luisa Di Marzio, Armando Cevenini, Michele Costanzo, Nicola d'Avanzo, Massimo Fresta, Stefania Orrù, Christian Celia and Francesco Salvatore

{"title":"Unraveling the impact of different liposomal formulations on the plasma protein corona composition might give hints on the targeting capability of nanoparticles†","authors":"Esther Imperlini, Luisa Di Marzio, Armando Cevenini, Michele Costanzo, Nicola d'Avanzo, Massimo Fresta, Stefania Orrù, Christian Celia and Francesco Salvatore","doi":"10.1039/D4NA00345D","DOIUrl":"10.1039/D4NA00345D","url":null,"abstract":"Nanoparticles (NPs) interact with biological fluids after being injected into the bloodstream. The interactions between NPs and plasma proteins at the nano-bio interface affect their biopharmaceutical properties and distribution in the organ and tissues due to protein corona (PrC) composition, and in turn, modification of the resulting targeting capability. Moreover, lipid and polymer NPs, at their interface, affect the composition of PrC and the relative adsorption and abundance of specific proteins. To investigate this latter aspect, we synthesized and characterized different liposomal formulations (LFs) with lipids and polymer-conjugated lipids at different molar ratios, having different sizes, size distributions and surface charges. The PrC composition of various designed LFs was evaluated ex vivo in human plasma by label-free quantitative proteomics. We also correlated the relative abundance of identified specific proteins in the coronas of the different LFs with their physicochemical properties (size, PDI, zeta potential). The evaluation of outputs from different bioinformatic tools discovered protein clusters allowing to highlight: (i) common as well as the unique species for the various formulations; (ii) correlation between each identified PrC and the physicochemical properties of LFs; (iii) some preferential binding determined by physicochemical properties of LFs; (iv) occurrence of formulation-specific protein patterns in PrC. Investigating specific clusters in PrC will help decode the multivalent roles of the protein pattern components in the drug delivery process, taking advantage of the bio-nanoscale recognition and identification for significant advances in nanomedicine.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/na/d4na00345d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141518927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outstanding Reviewers for Nanoscale Advances in 2023 2023 年纳米技术进展》杰出评审员

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2024-07-01 DOI: 10.1039/D4NA90067G

引用次数: 0