Nanoscale Advances最新文献_第9页

Revolutionizing green catalysis: a novel amla seed derived biochar modified g-C₃N₄·SO₃H catalyst for sustainable and versatile synthesis of bis-indoles.

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-01-13 DOI: 10.1039/d4na00891j

Shivani Soni, Sunita Teli, Pankaj Teli, Shikha Agarwal

{"title":"Revolutionizing green catalysis: a novel amla seed derived biochar modified g-C3N4·SO3H catalyst for sustainable and versatile synthesis of bis-indoles.","authors":"Shivani Soni, Sunita Teli, Pankaj Teli, Shikha Agarwal","doi":"10.1039/d4na00891j","DOIUrl":"https://doi.org/10.1039/d4na00891j","url":null,"abstract":"Catalysis plays a vital role in green chemistry by improving process efficiency, reducing waste, and minimizing environmental impact. A biochar-modified g-C3N4·SO3H (BCNSA) catalyst was developed using biochar derived from amla seed powder and CNSA. CNSA was synthesized via the reaction of g-C3N4 with chlorosulfonic acid. Both components were combined, pyrolyzed, purified, and comprehensively characterized using FTIR, XRD, FE-SEM, EDX, elemental mapping, TGA, and DTA studies to confirm the successful synthesis and structural integrity. The catalyst demonstrated exceptional efficiency in synthesizing bis-indole derivatives through reactions between substituted indoles (indole, 1-methyl indole, and 6-chloro indole) and carbonyl-containing compounds, including isatins (isatin, 7-(trifluoromethyl)isatin, 5-bromo isatin, and 5-fluoro isatin), aldehydes, cyclo-ketones, dimedone, and acetophenones. These reactions were carried out under simplified conditions using water as a green solvent, promoting sustainability and versatility. A total of 21 bis-indole products were synthesized within 5-45 minutes, achieving yields of 80-98% showcasing the catalyst's outstanding performance. Furthermore, the method was scaled up to gram-level synthesis, and green chemistry metrics were evaluated for all the products, highlighting the environmental and economic benefits of this approach.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering Au single-atom sites embedded in TiO₂ nanostructures for boosting photocatalytic methane oxidation.

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-01-13 DOI: 10.1039/d4na00947a

Qui Thanh Hoai Ta, Ly Tan Nhiem

引用次数: 0

Pyrroloquinoline quinone-loaded coaxial nanofibers prevent oxidative stress after spinal cord injury.

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-01-09 DOI: 10.1039/d4na00885e

Sara Ibrahim, Mohammed Ismail, Taghrid Abdelrahman, Mona Sharkawy, Ahmed Abdellatif, Nageh K Allam

{"title":"Pyrroloquinoline quinone-loaded coaxial nanofibers prevent oxidative stress after spinal cord injury.","authors":"Sara Ibrahim, Mohammed Ismail, Taghrid Abdelrahman, Mona Sharkawy, Ahmed Abdellatif, Nageh K Allam","doi":"10.1039/d4na00885e","DOIUrl":"10.1039/d4na00885e","url":null,"abstract":"Oxidative stress plays a major role in the secondary injury of the spinal cord tissue due to the high lipid content of nervous tissue. In the present study, coaxial nanofibers were loaded with the natural antioxidant pyrroloquinoline quinone (PQQ) and used as an implantable drug-delivery system and a scaffold post-SCI. The obtained data show that the concentration of NO and the activity of inducible nitric oxide synthase (iNOS) were significantly (P < 0.05) increased in the spinal cord injury (SCI) group. These levels were significantly decreased following treatment with nanofibers/PQQ. Implantation of nanofibers/PQQ resulted in a significant (P < 0.05) drop in the level of malondialdehyde (MDA) compared to the SCI group. The application of nanofibers loaded with PQQ after SCI caused a significant (P < 0.05) elevation of superoxide dismutase (SOD) and catalase (CAT) activity in the spinal cord tissue. The present work shows the protective role of coaxial nanofibers loaded with PQQ against oxidative stress in spinal cord injury. The reversal of oxidative stress with PQQ can lead to better outcomes following spinal cord injury.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the structure-property correlations of pyrolyzed phenolic resin as a function of degree of carbonization.

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-01-09 DOI: 10.1039/d4na00824c

Ivan Gallegos, Vikas Varshney, Josh Kemppainen, Gregory M Odegard

{"title":"Investigating the structure-property correlations of pyrolyzed phenolic resin as a function of degree of carbonization.","authors":"Ivan Gallegos, Vikas Varshney, Josh Kemppainen, Gregory M Odegard","doi":"10.1039/d4na00824c","DOIUrl":"10.1039/d4na00824c","url":null,"abstract":"Carbon-carbon (C/C) composites are attractive materials for high-speed flights and terrestrial atmospheric reentry applications due to their insulating thermal properties, thermal resistance, and high strength-to-weight ratio. It is important to understand the evolving structure-property correlations in these materials during pyrolysis, but the extreme laboratory conditions required to produce C/C composites make it difficult to quantify the properties in situ. This work presents an atomistic modeling methodology to pyrolyze a crosslinked phenolic resin network and track the evolving thermomechanical properties of the skeletal matrix during simulated pyrolysis. First, the crosslinked resin is pyrolyzed and the resulting char yield and mass density are verified to match experimental values, establishing the model's powerful predictive capabilities. Young's modulus, yield stress, Poisson's ratio, and thermal conductivity are calculated for the polymerized structure, intermediate pyrolyzed structures, and fully pyrolyzed structure to reveal structure-property correlations, and the evolution of properties are linked to observed structural features. It is determined that reduction in fractional free volume and densification of the resin during pyrolysis contribute significantly to the increase in thermomechanical properties of the skeletal phenolic matrix. A complex interplay of the formation of six-membered carbon rings at the expense of five and seven-membered carbon rings is revealed to affect thermal conductivity. Increased anisotropy was observed in the latter stages of pyrolysis due to the development of aligned aromatic structures. Experimentally validated predictive atomistic models are a key first step to multiscale process modeling of C/C composites to optimize next-generation materials.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143059632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective modal excitation in a multimode nanoslit by interference of surface plasmon waves 表面等离子体波干涉下多模纳米狭缝的选择性模态激发。

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-01-09 DOI: 10.1039/D4NA00862F

Marcos Valero, Luis-Angel Mayoral-Astorga, Howard Northfield, Hyung Woo Choi, Israel De Leon, Mallar Ray and Pierre Berini

{"title":"Selective modal excitation in a multimode nanoslit by interference of surface plasmon waves","authors":"Marcos Valero, Luis-Angel Mayoral-Astorga, Howard Northfield, Hyung Woo Choi, Israel De Leon, Mallar Ray and Pierre Berini","doi":"10.1039/D4NA00862F","DOIUrl":"10.1039/D4NA00862F","url":null,"abstract":"Interference of surface plasmons has been widely utilized in optical metrology for applications such as high-precision sensing. In this paper, we introduce a surface plasmon interferometer with the potential to be arranged in arrays for parallel multiplexing applications. The interferometer features two grating couplers that excite surface plasmon polariton (SPP) waves traveling along a gold–air interface before converging at a gold nanoslit where they interfere. A key innovation lies in the ability to tune the interference pattern by altering the geometrical properties of the gold nanoslit such that one, two or more resonance modes are supported in the nanoslit. Our experimental results validate the approach of our design and modelling process, demonstrating the potential to fine-tune geometrical parameters such as grating coupler pitch, depth, duty cycle, and nanoslit dimensions to alter the transmitted radiation pattern and the transmittance. We demonstrate the ability of a grating coupler to induce focusing of SPP waves to an arbitrary location on chip by illuminating with a converging Gaussian beam. Additionally, we observed far-field interference patterns linked to the multimodal operation of the nanoslit.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 5","pages":" 1305-1317"},"PeriodicalIF":4.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11718371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microwave-assisted synthesis of highly photoluminescent core/shell CuInZnSe/ZnS quantum dots as photovoltaic absorbers† 微波辅助合成高光致发光核/壳型CuInZnSe/ZnS量子点作为光伏吸收剂。

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-01-09 DOI: 10.1039/D4NA00893F

Shubham Shishodia, Hervé Rinnert, Lavinia Balan, Jordane Jasniewski, Stéphanie Bruyère, Ghouti Medjahdi, Thomas Gries and Raphaël Schneider

引用次数: 0

Impact of gold nanoparticle size and coating on radiosensitization and generation of reactive oxygen species in cancer therapy† 金纳米颗粒尺寸和涂层对肿瘤治疗中放射敏化和活性氧生成的影响。

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-01-09 DOI: 10.1039/D4NA00773E

E. Loscertales, R. López-Méndez, J. Mateo, L. M. Fraile, J. M. Udias, A. Espinosa and S. España

{"title":"Impact of gold nanoparticle size and coating on radiosensitization and generation of reactive oxygen species in cancer therapy†","authors":"E. Loscertales, R. López-Méndez, J. Mateo, L. M. Fraile, J. M. Udias, A. Espinosa and S. España","doi":"10.1039/D4NA00773E","DOIUrl":"10.1039/D4NA00773E","url":null,"abstract":"Radiation therapy is a common cancer treatment but often damages surrounding healthy tissues, leading to unwanted side effects. Despite technological advancements aimed at improving targeting, minimizing exposure to normal cells remains a major challenge. High-Z nanoparticles, such as gold nanoparticles (AuNPs), are being explored as nano-radiosensitizers to enhance cancer treatment through physical, biological, and chemical mechanisms. This study focuses on evaluating the chemical and biological radiosensitizing effects of AuNPs exposed to ionizing radiation (0–50 Gy), specifically their production of reactive oxygen species (ROS) and their impact on cancer cells. ROS generated by AuNPs of varying sizes and coatings were quantified using fluorescence probes for hydroxyl radicals (HO·) and singlet oxygen (1O2). The radiosensitizing effects on MDA-MB-231 cancer cells were assessed via clonogenic assays. Our results show a clear dependence of ROS production on AuNP size. Interestingly, PEG-capped AuNPs did not significantly enhance HO· production but greatly increased 1O2 production, suggesting that multiple reactive species contribute to the radiosensitization process. Clonogenic assays confirmed that PEG-capped AuNPs produced stronger radiosensitizing effects than citrate-capped AuNPs, with smaller AuNPs providing more pronounced biological effects. This study underscores the importance of conducting both chemical and biological evaluations to fully understand the radiosensitization efficacy of AuNPs.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 4","pages":" 1204-1214"},"PeriodicalIF":4.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11712209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymeric nanoparticles with a thermoresponsive shell loaded with fluorescent molecules allow for thermally enhanced fluorescence imaging and singlet oxygen generation.

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-01-09 DOI: 10.1039/d4na00687a

Oksana Chepurna, Artem Yakovliev, Roman Ziniuk, Anna Grebinyk, Hao Xu, Olena A Nikolaeva, Andrii I Marynin, Liudmyla O Vretik, Junle Qu, Tymish Y Ohulchanskyy

{"title":"Polymeric nanoparticles with a thermoresponsive shell loaded with fluorescent molecules allow for thermally enhanced fluorescence imaging and singlet oxygen generation.","authors":"Oksana Chepurna, Artem Yakovliev, Roman Ziniuk, Anna Grebinyk, Hao Xu, Olena A Nikolaeva, Andrii I Marynin, Liudmyla O Vretik, Junle Qu, Tymish Y Ohulchanskyy","doi":"10.1039/d4na00687a","DOIUrl":"10.1039/d4na00687a","url":null,"abstract":"A thermosensitive polymeric nanoformulation (NF) was fabricated for thermally enhanced near-infrared (NIR) fluorescence imaging (FLI). It comprised core-shell nanoparticles (NPs) with a polystyrene core and a thermosensitive shell of a co-polymer of N-isopropylacrylamide and acrylamide [poly(NIPAM-co-AA)], which underwent a reversible conformational transition at 38-40 °C (corresponding to a lower critical solution temperature, LCST), leading to a reversible shrinkage of NPs from ∼250 nm to ∼140 nm for temperatures above LCST. The NIR dye 3782SL or photosensitizer HPPH were loaded to the NP shells. While the fluorescence of 3782SL and HPPH was quenched in water, it recovered in the NPs dispersion as a result of adsorption by NPs. Fluorescence for 3782SL and HPPH in NF increased when the temperature increased above LCST. Heating of HPPH-loaded NFs led to the elongation of the HPPH fluorescence lifetime and increased the generation of singlet oxygen (1O2). This occurred as a result of the NP shrinkage, corresponding shell compaction and NP aggregation, which hindered the internal conversion for photoexcited molecules adsorbed by NPs, and resulted in an increase in other deactivation pathways, namely fluorescence emission and intersystem crossing. The latter led to an increase in the triplet yield and, consequently, in singlet oxygen generation. Fluorescence microscopy revealed a 2-3-fold increase in the 3782SL or HPPH fluorescence signal from the NF-treated cells after they were heated up to 40 °C. Comparable results were obtained for the FLI of mice in vivo, after subcutaneous, intravenous, or intratumoral NF injections and localized heating by NIR (1.3 μm) laser irradiation. The developed NF holds immense potential for thermally enhanced FLI and photodynamic therapy.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engaging a highly fluorescent conjugated polymer network for probing endogenous hypochlorite in macrophage cells: improved sensitivity via signal amplification† 利用高荧光共轭聚合物网络探测巨噬细胞内源性次氯酸盐：通过信号放大提高灵敏度。

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-01-08 DOI: 10.1039/D4NA00728J

Rikitha S. Fernandes, Neelam Gupta, Ch Sanjay, Anamika, Ambati Himaja, Balaram Ghosh, Biplab Kumar Kuila and Nilanjan Dey

{"title":"Engaging a highly fluorescent conjugated polymer network for probing endogenous hypochlorite in macrophage cells: improved sensitivity via signal amplification†","authors":"Rikitha S. Fernandes, Neelam Gupta, Ch Sanjay, Anamika, Ambati Himaja, Balaram Ghosh, Biplab Kumar Kuila and Nilanjan Dey","doi":"10.1039/D4NA00728J","DOIUrl":"10.1039/D4NA00728J","url":null,"abstract":"We have employed a triazine-based conjugated polymer network (CPN) for the selective detection of hypochlorite in a semi-aqueous environment. CPNs have been widely employed in gas capture, separation, and adsorption, but the fluorescent properties of CPNs possessing extensive π-conjugated systems tend to be unexplored. Herein, we report the photophysical properties of the CPN and investigate its sensing capability towards hypochlorite. Spectroscopic investigations reveal that the CPN forms π-stacked aggregates in aqueous medium, while loose aggregates were observed to be formed in hydrophobic solvents. The fluorogenic CPN demonstrates remarkable selectivity via fluorescence quenching and a blueshift response towards hypochlorite in a semi-aqueous medium, accompanied by a color change under UV light. Such a turn-off fluorescence response, along with the blue shift upon hypochlorite sensing, was attributed to the oxidation of the sulfur atom of the thiophene functionality of the CPN, consequently resulting in suppression of Intramolecular Charge Transfer (ICT) in the corresponding oxidized adduct. The fluorescence intensity of the CPN exhibits a linear response to hypochlorite concentration, achieving a low detection limit of 1.2 nM. Furthermore, the practical applicability was demonstrated by the detection of hypochlorite in water samples and fluorescent test-paper strips. Additionally, the present system is utilized for bio-imaging of endogenous hypochlorite in RAW 264.7 cells.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 4","pages":" 1183-1194"},"PeriodicalIF":4.6,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11708206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A customizable wireless potentiostat for assessing Ni(OH)2 decorated vertically aligned MoS2 thin films for electrochemical sensing of dopamine†

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-01-08 DOI: 10.1039/D4NA00914B

Topias Järvinen, Olli Pitkänen, Tomi Laurila, Minna Mannerkorpi, Simo Saarakkala and Krisztian Kordas

引用次数: 0