Nanoscale Advances最新文献

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Microwave characterization of plasmonic antennas through electron energy loss spectroscopy† 等离子体天线的微波特性的电子能量损失谱。
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-03-19 DOI: 10.1039/D4NA00960F
Igor Getmanov, Qingxiao Wang, Heng Wang, Atif Shamim and Dalaver H. Anjum
{"title":"Microwave characterization of plasmonic antennas through electron energy loss spectroscopy†","authors":"Igor Getmanov, Qingxiao Wang, Heng Wang, Atif Shamim and Dalaver H. Anjum","doi":"10.1039/D4NA00960F","DOIUrl":"10.1039/D4NA00960F","url":null,"abstract":"<p >The absence of suitable equipment has long hindered traditional microwave characterization of nano-antennas and their effective design at frequencies beyond several terahertz, limiting the exploration of the myriad applications of plasmonic antennas by the microwave engineering community and necessitating a paradigm shift in characterization methods. This work addresses this challenge by introducing a novel approach employing electron energy loss spectroscopy (EELS) to characterize input impedance and scattering parameters of plasmonic antennas from mid-infrared to optical frequencies. Central to this method is a newly developed theoretical framework that links electron energy loss probability with microwave scattering parameters, crucial for antenna design. We validated this approach through a study of a single plasmonic dipole, finding a good correspondence between the measured EEL spectra and our theoretical model, supported by our developed simulation model. Drawing upon this correlation, we proposed an algorithm for the reverse procedure of extracting <em>S</em>-parameters and input impedance from experimental EEL probability. Spatial profiles of input impedance and <em>S</em>-parameters for a single plasmonic dipole were experimentally characterized across the broad frequency spectrum ranging from 25 to 150 THz and compared with simulation results, revealing a robust correlation, particularly at resonant frequencies. Our non-contact method could serve as an alternative approach to microwave parameters characterization, functioning similarly to a vector network analyzer (VNA) but extending its capabilities to much higher frequencies, where VNAs are not available.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 9","pages":" 2695-2708"},"PeriodicalIF":4.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949246/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plant extract-mediated green-synthesized CuO nanoparticles for environmental and microbial remediation: a review covering basic understandings to mechanistic study 植物提取物介导的绿色合成氧化铜纳米颗粒用于环境和微生物修复:从基本认识到机理研究的综述
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-03-19 DOI: 10.1039/D5NA00035A
Mashrafi Bin Mobarak, MD. Foysal Sikder, Khandakar Sidratul Muntaha, Shariful Islam, S. M. Fazle Rabbi and Fariha Chowdhury
{"title":"Plant extract-mediated green-synthesized CuO nanoparticles for environmental and microbial remediation: a review covering basic understandings to mechanistic study","authors":"Mashrafi Bin Mobarak, MD. Foysal Sikder, Khandakar Sidratul Muntaha, Shariful Islam, S. M. Fazle Rabbi and Fariha Chowdhury","doi":"10.1039/D5NA00035A","DOIUrl":"https://doi.org/10.1039/D5NA00035A","url":null,"abstract":"<p >This review provides a comprehensive overview of nanoparticles, with a particular focus on plant extract-mediated green-synthesized copper oxide nanoparticles (CuO NPs). This article is one of the simplest to read as it aims at beginner researchers, who may not have advanced knowledge on topics like nanoparticles, including metal and metal oxide nanoparticles, their classification, and techniques to prepare them. Various synthesis procedures are discussed, emphasizing green synthesis methods that utilize plant extracts as reducing and stabilizing agents. Subsequently, the mechanisms involved in the formation of CuO NPs are highlighted. Their significant applications with a mechanistic overview on environmental remediation, especially in the eradication of textile dyes and pharmaceutical wastes, and their antimicrobial properties are elucidated. By carefully scrutinizing the information available in the literature, this article aims to equip novice researchers with a foundational understanding of nanoparticles, their synthesis, and their practical applications, fostering further exploration in the field of nanotechnology.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 9","pages":" 2418-2445"},"PeriodicalIF":4.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/na/d5na00035a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the antimicrobial activity of chitosan- and curcumin-capped copper oxide nanostructures against multi-drug-resistant microorganisms† 壳聚糖和姜黄素覆盖氧化铜纳米结构对多重耐药微生物的抗菌活性评价。
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-03-19 DOI: 10.1039/D4NA00955J
Noura El-Kattan, Mostafa A. Ibrahim, Ahmed N. Emam, Khaled Metwally, Fady Sayed Youssef, Nourelhuda Ahmed Nassar and Ahmed S. Mansour
{"title":"Evaluation of the antimicrobial activity of chitosan- and curcumin-capped copper oxide nanostructures against multi-drug-resistant microorganisms†","authors":"Noura El-Kattan, Mostafa A. Ibrahim, Ahmed N. Emam, Khaled Metwally, Fady Sayed Youssef, Nourelhuda Ahmed Nassar and Ahmed S. Mansour","doi":"10.1039/D4NA00955J","DOIUrl":"10.1039/D4NA00955J","url":null,"abstract":"<p >The emergence of multi-drug-resistant microorganisms presents a serious threat to infection control, for which new antimicrobial strategies are urgently needed. Herein, the antimicrobial activities of copper oxide nanoparticles capped with curcumin (Cur-CuO NPs) and copper oxide nanoparticles capped with chitosan (CS-CuO NPs) were investigated. They were prepared <em>via</em> the co-precipitation method. A total of 180 clinical ICU patients were found to have 70% Gram-negative and 30% Gram-positive isolates. Antimicrobial susceptibility testing indicated resistance of these isolates to 14 among the 21 tested antibiotics. Physicochemical properties of the curcumin-capped (Cur-CuO NPs) and chitosan-capped (CS-CuO NPs) copper oxide nanoparticles were identified using UV-vis spectroscopy, transmission electron microscopy (TEM), dynamic light scattering (DLS), zeta-potential (<em>ζ</em>), and Fourier transform infrared (FT-IR) spectroscopy. Cur-CuO- and CS-CuO-NPs exhibited potent antimicrobial efficacy, wherein CS-CuO NPs were found to possess a lower minimum inhibitory concentration (MIC) (3.9–15.6 μg mL<small><sup>−1</sup></small>) than Cur-CuO NPs (14.5–31.2 μg mL<small><sup>−1</sup></small>). Biocompatibility assay showed that Cur-CuO NPs were safer with an IC<small><sub>50</sub></small> dose of 74.17 μg mL<small><sup>−1</sup></small> than CS-CuO NPs with an IC<small><sub>50</sub></small> dose of 41.01 μg mL<small><sup>−1</sup></small>. Results revealed that the Cur-CuO- and CS-CuO-NPs have the potential to be safely used as effective antimicrobial agents in clinical applications at low concentrations (6.25–12.5 μg mL<small><sup>−1</sup></small>).</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 10","pages":" 2988-3007"},"PeriodicalIF":4.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive review on nano-fertilizers: preparation, development, utilization, and prospects for sustainable agriculture in Ethiopia 纳米肥料综合综述:埃塞俄比亚可持续农业的制备、开发、利用和前景。
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-03-19 DOI: 10.1039/D4NA01068J
Eyasu Derbew Demeke, Natei Ermias Benti, Mintesnot Gizaw Terefe, Teshome Taye Anbessa, Wondimagegne Mamo Mengistu and Yedilfana Setarge Mekonnen
{"title":"A comprehensive review on nano-fertilizers: preparation, development, utilization, and prospects for sustainable agriculture in Ethiopia","authors":"Eyasu Derbew Demeke, Natei Ermias Benti, Mintesnot Gizaw Terefe, Teshome Taye Anbessa, Wondimagegne Mamo Mengistu and Yedilfana Setarge Mekonnen","doi":"10.1039/D4NA01068J","DOIUrl":"10.1039/D4NA01068J","url":null,"abstract":"<p >With their many benefits including better crop yield and nutrient delivery, nano fertilizers are a promising option in the agriculture sector. The production and formulation of nanoparticles with regulated size, shape, and content are required to prepare nano fertilizers. Metals, metal oxides, and polymers are among the materials from which nanoparticles are made using chemical and physical processes. Subsequently, these nanoparticles are mixed into fertilizers to enhance plant absorption and availability of nutrients. Nano-fertilizers have several benefits, including efficient nutrient absorption, reduced nutrient losses, minimized environmental pollution, optimized resource utilization, and controlled release of nutrients for sustained plant nourishment. Studies have demonstrated that by boosting nutrient availability, encouraging root development, and strengthening stress tolerance, nano fertilizers can greatly enhance crop yields. Moreover, it has been discovered that they increase microbial activity and soil fertility, which improves soil health and long-term sustainability. Nano-fertilizers can be applied in different ways, like foliar spraying, seed coating, soil integration, or irrigation systems. They are beneficial in precision agriculture for better nutrient management, soil restoration, and addressing nutrient deficiencies. Furthermore, they potentially lessen the negative environmental effects of traditional fertilization methods. Nevertheless, there are still several issues that need to be resolved before nano fertilizers may be commercialized and widely used. Regulatory frameworks, environmental destiny, potential toxicity of nanoparticles, and cost-effectiveness are some of these challenges. The purpose of this review is to provide readers with a comprehensive understanding of the benefits of nano fertilizers. It will cover topics such as their preparation and characterization, potential side effects, and a diverse range of applications. Additionally, it will present an overview of the importation of chemical fertilizers and explore the prospects of utilizing fertilizers in the Ethiopian context.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 8","pages":" 2131-2144"},"PeriodicalIF":4.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A nitrogen and phosphorus enriched inorganic–organic hybrid material for electrochemical detection of selenium(iv) ions† 富氮富磷无机-有机杂化材料电化学检测硒离子。
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-03-18 DOI: 10.1039/D5NA00079C
Arun Kumar, Prakriti Thakur, Nisha Dhiman, Sachin Balhara and Paritosh Mohanty
{"title":"A nitrogen and phosphorus enriched inorganic–organic hybrid material for electrochemical detection of selenium(iv) ions†","authors":"Arun Kumar, Prakriti Thakur, Nisha Dhiman, Sachin Balhara and Paritosh Mohanty","doi":"10.1039/D5NA00079C","DOIUrl":"10.1039/D5NA00079C","url":null,"abstract":"<p >A heteroatom (nitrogen and phosphorus) enriched pyridinic bridged inorganic–organic hybrid material (HPHM) was synthesized by polycondensing phosphonitrilic chloride trimer (PNC) and 2,6-diaminopyridine in DMSO at 140 °C. The synthesized material was used as an efficient electrode material for the electrochemical detection of selenium(<small>IV</small>) ions [Se(<small>IV</small>)] in aqueous solution. The HPHM electrode (active mass loading of 4.1 mg cm<small><sup>−2</sup></small>) achieves a detection range of 5–50 ppb at a deposition potential of −1.2 V and a deposition time of 170 s with a lower limit of detection (LOD) of 2.18 ppb. This LOD is significantly below the World Health Organization's (WHO) recommended maximum level for selenium in drinking water. Moreover, the electrode material maintains high selectivity for Se(<small>IV</small>) ions in the presence of various interfering ions and high sensitivity over 200 cycles with only a minimal (∼6.83%) decline in current density response. The higher Se(<small>IV</small>) ion detection capability is attributed to the strategic incorporation of nitrogen and phosphorus heteroatoms, enhancing the material's electrochemical properties.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 9","pages":" 2626-2633"},"PeriodicalIF":4.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical synthesis of NdxCo1−xFe2O4 hybrid nanoparticles for permanent magnet applications: structural, magnetic and electrical properties 用于永磁体的Nd x Co1-x Fe2O4杂化纳米粒子的化学合成:结构、磁性和电学性质。
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-03-18 DOI: 10.1039/D5NA00197H
Saleh M. Matar, Galal H. Ramzy, Muhammad Arif, Ibrahim M. Maafa, Ayman Yousef, Nasser Zouli, Ahmed F. F. Abouatiaa, Abdel Samed M. Adam, Isam Y. Qudsieh, Ahmed I. Ali, Elbadawy A. Kamoun and Amr Ali
{"title":"Chemical synthesis of NdxCo1−xFe2O4 hybrid nanoparticles for permanent magnet applications: structural, magnetic and electrical properties","authors":"Saleh M. Matar, Galal H. Ramzy, Muhammad Arif, Ibrahim M. Maafa, Ayman Yousef, Nasser Zouli, Ahmed F. F. Abouatiaa, Abdel Samed M. Adam, Isam Y. Qudsieh, Ahmed I. Ali, Elbadawy A. Kamoun and Amr Ali","doi":"10.1039/D5NA00197H","DOIUrl":"10.1039/D5NA00197H","url":null,"abstract":"<p >Nd-doped CoFe<small><sub>2</sub></small>O<small><sub>4</sub></small> spinel ferrites were synthesized <em>via</em> the sol–gel method, confirming a cubic spinel structure. Increasing Nd concentration expanded the lattice parameter (8.3900–8.4231 Å) and unit cell volume while reducing grain size. FT-IR analysis validated the spinel phase. Nd doping enhanced the dielectric constant by affecting space charge polarization and charge hopping, with conductivity following a Debye-type relaxation mechanism. Cole–Cole plots indicated grain boundary effects and polaron hopping conduction. Magnetic properties improved with Nd<small><sup>3+</sup></small> content, with <em>M</em><small><sub>s</sub></small> and <em>H</em><small><sub>c</sub></small> reaching 5.621 emu g<small><sup>−1</sup></small> and 143.43 Oe at 4% doping. A transition from an antiferromagnetic to a ferromagnetic state was observed, with a high Curie temperature (<em>T</em><small><sub>m</sub></small>) of 292 °C, confirming a stable ferromagnetic phase. These findings highlight Nd-doped CoFe<small><sub>2</sub></small>O<small><sub>4</sub></small> as a promising candidate for permanent magnet applications.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 9","pages":" 2725-2741"},"PeriodicalIF":4.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polarity-sensitive dual emissive fluorescent carbon dots as highly specific targeting probes for lipid droplets in live cells† 极性敏感双发射荧光碳点作为活细胞中脂滴的高度特异性靶向探针。
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-03-18 DOI: 10.1039/D5NA00061K
Aminakutty Neerkattil, M. M. Bijeesh, K. K. Ghosh, Parasuraman Padmanabhan, Balázs Gulyás, V. M. Murukeshan and Jayeeta Bhattacharyya
{"title":"Polarity-sensitive dual emissive fluorescent carbon dots as highly specific targeting probes for lipid droplets in live cells†","authors":"Aminakutty Neerkattil, M. M. Bijeesh, K. K. Ghosh, Parasuraman Padmanabhan, Balázs Gulyás, V. M. Murukeshan and Jayeeta Bhattacharyya","doi":"10.1039/D5NA00061K","DOIUrl":"10.1039/D5NA00061K","url":null,"abstract":"<p >Polarity-sensitive fluorescent nanoparticles with intrinsic dual emission are invaluable tools for investigating microenvironmental polarity. Ratiometric fluorescent sensors, with their built-in self-calibration characteristics, offer higher sensitivity and more obvious visual detection in qualitative and quantitative analysis. In this context, we report the synthesis of polarity-sensitive, dual-emitting carbon dots <em>via</em> a solvothermal method and demonstrate their application in ratiometric polarity sensing. These carbon dots exhibit characteristic solvatochromic effects with emissions in both the blue and red spectral regions. Notably, we observed a remarkable 30-fold enhancement in the red-to-blue emission intensity ratio as the solvent polarity shifted from 0.245 to 0.318. The dual-emitting carbon dots demonstrate the highly sensitive and inherently reliable (self-calibration) polarity dependence of the emission spectra, facilitating their application in ratiometric polarity sensing. These dual-emitting carbon dots exhibited a strong affinity for lipid droplets in live cells, demonstrating their potential as highly specific targeting probes for imaging lipid droplets in live cells, without the need for additional targeting ligands. The characteristics of excellent biocompatibility, photostability, and good cellular imaging capabilities make these dual-emitting carbon dots highly promising for biomedical and sensing applications.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 9","pages":" 2686-2694"},"PeriodicalIF":4.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Battery-type CuCo2O4/CoS nanograss arrays as a binder-free advanced electrode material for high-performance supercapacitors† 电池型CuCo2O4/CoS纳米草阵列作为高性能超级电容器的无粘结剂高级电极材料。
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-03-17 DOI: 10.1039/D5NA00070J
Chandu V. V. Muralee Gopi, Araveeti Eswar Reddy, Sunkara Srinivasa Rao, K. V. G. Raghavendra, Maduru Suneetha, Hee-Je Kim and R. Ramesh
{"title":"Battery-type CuCo2O4/CoS nanograss arrays as a binder-free advanced electrode material for high-performance supercapacitors†","authors":"Chandu V. V. Muralee Gopi, Araveeti Eswar Reddy, Sunkara Srinivasa Rao, K. V. G. Raghavendra, Maduru Suneetha, Hee-Je Kim and R. Ramesh","doi":"10.1039/D5NA00070J","DOIUrl":"10.1039/D5NA00070J","url":null,"abstract":"<p >This study uses a facile one-step hydrothermal method to successfully synthesize hierarchical dandelion flower-like CuCo<small><sub>2</sub></small>O<small><sub>4</sub></small>/CoS structures on Ni foam. The composite exhibits a unique dandelion flower-like architecture comprising interconnected nanograss arrays (NGAs), resulting in a significantly higher surface area than individual CuCo<small><sub>2</sub></small>O<small><sub>4</sub></small> and CoS electrodes. Electrochemical characterization reveals that the CuCo<small><sub>2</sub></small>O<small><sub>4</sub></small>/CoS electrode exhibits superior electrochemical performance, demonstrating battery-type behavior with well-defined redox peaks in cyclic voltammetry and distinct plateaus in galvanostatic charge–discharge curves. The composite electrode delivers a high specific capacity of 217.86 mA h g<small><sup>−1</sup></small> at a current density of 6 mA cm<small><sup>−2</sup></small>, surpassing the performance of individual CuCo<small><sub>2</sub></small>O<small><sub>4</sub></small> (142.54 mA h g<small><sup>−1</sup></small>) and CoS (160.37 mA h g<small><sup>−1</sup></small>) electrodes. Moreover, the composite electrodes exhibit outstanding cycling life, retaining 86.23% of their initial capacity in over 3000 cycles. Electrochemical impedance spectroscopy analysis confirms lower charge transfer resistance and solution resistance for the composite electrode, indicating improved charge transfer kinetics and ion diffusion. These findings demonstrate that the hierarchical CuCo<small><sub>2</sub></small>O<small><sub>4</sub></small>/CoS composite holds significant promise as a high-performance battery-type electrode material for supercapacitor applications.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 9","pages":" 2742-2750"},"PeriodicalIF":4.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Folate receptor-targeted pH-sensitive liposomes loaded with TGX-221 against prostate cancer by inhibiting PI3K/110β signaling. 叶酸受体靶向ph敏感脂质体负载TGX-221通过抑制PI3K/110β信号传导抑制前列腺癌。
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-03-14 DOI: 10.1039/d5na00009b
Weibo Xu, Xiaohan Li, Fujin He, Han Zhao, Jing Wu, Mengyu Li, Xiaoying Dai, Yanmin Li, Xiaojiao Hu, Xiaodong Li, Juan Cen, Peng Guo, Shaofeng Duan
{"title":"Folate receptor-targeted pH-sensitive liposomes loaded with TGX-221 against prostate cancer by inhibiting PI3K/110β signaling.","authors":"Weibo Xu, Xiaohan Li, Fujin He, Han Zhao, Jing Wu, Mengyu Li, Xiaoying Dai, Yanmin Li, Xiaojiao Hu, Xiaodong Li, Juan Cen, Peng Guo, Shaofeng Duan","doi":"10.1039/d5na00009b","DOIUrl":"https://doi.org/10.1039/d5na00009b","url":null,"abstract":"<p><p>Prostate cancer (PCa) is the most common cancer in men and the leading cause of cancer death worldwide. Overactivation of PI3K signaling has been reported to be associated with PCa. TGX221 is an effective specific inhibitor of PI3K, but its clinical application is greatly limited due to its poor solubility. Herein, by using folic acid-PEG-cholesterol semi-succinate (FA-PEG-CHEMS) as the targeting component, we developed a folate receptor-targeted pH-sensitive liposomal delivery system loaded with TGX221 (FA-Lip-TGX221) that could realize effective delivery and controlled release of drugs in the tumor. The prepared liposomes exhibited a uniform particle size and high stability. In addition, FA-Lip-TGX221 could be effectively internalized by PC-3 cells due to its ability to target folate receptors, thereby accumulating in tumor tissues. Meanwhile, <i>in vitro</i> and <i>in vivo</i> experiments suggested that FA-Lip-TGX221 could activate the PERK-ATF4-CHOP signaling pathway by inhibiting PI3K/110β signaling in PCa, thus significantly promoting endoplasmic reticulum (ER) stress-mediated cancer cell death. In conclusion, FA-Lip-TGX221 is a promising nano-delivery vehicle for the treatment of PCa, and also provide valuable references for all tumors overexpressing folate receptors.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comprehensive review on carbonylation reactions: catalysis by magnetic nanoparticle-supported transition metals. 磁性纳米颗粒负载过渡金属催化羰基化反应的研究进展。
IF 4.6 3区 材料科学
Nanoscale Advances Pub Date : 2025-03-14 DOI: 10.1039/d5na00040h
Irfan Ahmad, Munthar Kedhim, Yashwantsinh Jadeja, Gargi Sangwan, Kavitha V, Aditya Kashyap, Shirin Shomurotova, Mosstafa Kazemi, Ramin Javahershenas
{"title":"A comprehensive review on carbonylation reactions: catalysis by magnetic nanoparticle-supported transition metals.","authors":"Irfan Ahmad, Munthar Kedhim, Yashwantsinh Jadeja, Gargi Sangwan, Kavitha V, Aditya Kashyap, Shirin Shomurotova, Mosstafa Kazemi, Ramin Javahershenas","doi":"10.1039/d5na00040h","DOIUrl":"https://doi.org/10.1039/d5na00040h","url":null,"abstract":"<p><p>Magnetic catalysts have become a crucial innovation in carbonylation reactions, providing a sustainable and highly efficient means of synthesizing compounds that contain carbonyl groups. This review article explores the diverse and significant role of magnetic catalysts in various carbonylation processes, emphasizing their essential contributions to improving reaction rates, selectivity, and recyclability of catalysts. The distinctive magnetic properties of these catalysts enable straightforward separation and recovery, a feature that significantly mitigates waste and reduces environmental impact. As a result, magnetic catalysts' environmental and economic advantages position them as key players in contemporary synthetic chemistry, driving the evolution of green chemistry practices. Particularly noteworthy is the combination of magnetic nanoparticles with transition metals, resulting in the development of robust catalytic systems that exploit the complementary effects of magnetism and catalysis. Recent advances have showcased the adaptability of magnetic nanoparticles supported by transition metal catalysts in various carbonylation reactions, including carbonylative coupling, alkoxy carbonylation, thio carbonylation, and amino carbonylation. This review meticulously examines the mechanistic aspects of how magnetic fields influenced catalytic performance between 2014 and the end of 2024.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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