Nanoscale Advances最新文献

{"title":"Advanced nanofiber therapy: multifunctional silver-nanoparticles@polyacrylonitrile incorporating Syzygium guineense extracts for enhanced in vivo diabetic wound-healing and robust antimicrobial defense","authors":"Teshale Ayano Begeno, Yaqi Zhang, Abdurohman Mengesha Yessuf, Tibebu Shiferaw Kassa, Ahmed M. Salama, Weiguo Wang and Zhenxia Du","doi":"10.1039/D5NA00343A","DOIUrl":"10.1039/D5NA00343A","url":null,"abstract":"<p >Green-synthesized silver nanoparticles (Bio-Ag NPs) derived from <em>Syzygium guineense</em> offer an eco-friendly, cost-effective platform with potent antibacterial activity and biocompatibility. These nanoparticles were integrated into electrospun polyacrylonitrile (PAN) nanofibers, creating Bio-Ag NPs@PAN nanocomposites for enhanced diabetic wound healing applications. The synthesized materials were systematically characterized using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The antibacterial efficacy of Bio-Ag NPs was evaluated against Gram-positive <em>Staphylococcus aureus</em> and Gram-negative <em>Escherichia coli</em>, demonstrating inhibition zones of 17.0 ± 0.310 mm and 16.3 ± 0.290 mm, respectively. Additionally, the antioxidant potential of Bio-Ag NPs was confirmed using the DPPH assay, highlighting their physiological benefits. <em>In vivo</em> studies on a diabetic rat revealed the remarkable wound-healing efficiency of Bio-Ag NPs@PAN nanofibers. Over 3, 7, 11, and 14 days, these nanofibers significantly enhanced wound closure by promoting re-epithelialization, fibroblast proliferation, and extracellular matrix formation. Notably, Bio-Ag NPs(B)@PAN nanofibers accelerated diabetic wound healing by 52%, 68%, 88%, and 99% on days 3, 7, 11, and 14, respectively, with increased collagen deposition. This study demonstrates the multifunctional capabilities of Bio-Ag NPs@PAN nanofibers in addressing the challenges associated with diabetic wound healing, offering faster recovery and improved wound closure. Furthermore, the findings underscore the potent antioxidant and antibacterial properties of Bio-Ag NPs, emphasizing their potential for diverse biomedical applications.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 19","pages":" 6158-6178"},"PeriodicalIF":4.6,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibrin/MoS2-nanosheet conductive hydrogels with programmed time scales and pathways for bioresorption","authors":"Vidushi Shukla, Willis T. Bilderback, Deisy Fernandes, Mark Daley, Rojry Basnet, Pushkaraj Joshi, Zidan Yang, Anubhav Tripathi, Jacob K. Rosenstein, Kareen Coulombe and Robert H. Hurt","doi":"10.1039/D5NA00377F","DOIUrl":"10.1039/D5NA00377F","url":null,"abstract":"<p >Electrically conductive hydrogels are of interest as scaffolds for tissue engineering applications involving the growth, implantation, or attachment of electrically active cells. Such hydrogels should exhibit soft mechanics, tunable conductivity to match native tissue, biocompatibility, and biodegradability into non-toxic, clearable species. Common conductors based on metals or polymers can be challenged by insufficient biocompatibility or biodegradability. A potential new alternative is the use of composites containing 1T-phase MoS<small>₂</small> nanosheet fillers, which have a metallic nature and undergo oxidative biodegradation over clinically useful time scales. Chemically exfoliated MoS<small>₂</small> is introduced into assembly protocols for fibrin hydrogels and the composites characterized by electrochemical impedance spectroscopy, which reveals a 400% increase in conductivity in the physiologically important mid-band region of 10<small>³</small>–10<small>⁴</small> hertz. <em>In vitro</em> studies on fibrin/MoS<small>₂</small> composite hydrogels show complex multipath biodegradation behaviors. Matrix metalloprotease action degrades fibrin to soluble protein, without attacking the nanosheets. The nanosheets degrade separately by H<small>₂</small>O<small>₂</small> oxidation to soluble molybdate in a self-limiting reaction inhibited by the catalysis of peroxide decomposition by the molybdate product. Genipin cross-linking is demonstrated as a method to stabilize the fibrin network, control the overall hydrogel monolith lifetime, and control the biodegradation pathway to avoid nanosheet release by early loss of the fibrin network. The composite degradation products were found to be non-cytotoxic to primary cardiac fibroblasts by the MTT assay. Overall, 1T-phase MoS<small>₂</small> nanosheets offer an attractive alternative to currently available inorganic or polymeric additives for creating conductive, bioresorbable, and biocompatible hydrogels.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 19","pages":" 6205-6219"},"PeriodicalIF":4.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural engineering of silver nanoparticles for enhanced photoacoustic imaging","authors":"Rui Zhang, Manuel Dias, Yanchen Li, Stephan Rütten, Fabian Kiessling, Twan Lammers and Roger M. Pallares","doi":"10.1039/D5NA00636H","DOIUrl":"10.1039/D5NA00636H","url":null,"abstract":"<p >Photoacoustic (PA) imaging is a diagnostic tool widely explored in (pre)clinical settings, as it combines the strengths of optical and ultrasound imaging, resulting in high contrast resolution and deep tissue penetration. Although PA imaging can directly visualize some endogenous molecules (<em>e.g.</em> deoxygenated and oxygenated hemoglobin), most of its applications require the administration of external probes, including organic dyes and inorganic nanoparticles. Despite being historically used for antimicrobial and wound healing applications, silver nanoparticles (AgNPs) possess clear merits for PA imaging, including tunable optical properties, high-quality localized surface plasmon (LSP) resonances, strong photothermal conversions, and photostability. In this study, we explored new PA imaging probes based on silver nanocores (with different morphologies and sizes) and polymer shells, and identified the structural features that provide improved biocompatibility, stability, and probe performance. Notably, the size and morphology of the cores strongly impacted the PA signal of the silver probes. For example, among the different particles tested, plate-shaped AgNPs generated up to 3-fold greater signal, as their optical properties, specifically LSP bands and extinction coefficients, were better suited for PA imaging. Even if nanoconstructs displayed apparent inadequate optical features, <em>e.g.</em> in the case of spherical AgNPs with LSP bands centered in the blue region of the spectrum, a strong PA signal could still be obtained by manipulating the core size, resulting in up to 2-fold greater signal for larger particles in comparison to their smaller counterparts. All AgNPs were stable in biological environments, did not photobleach, and preserved strong PA imaging signals in <em>ex vivo</em> setups. Taken together, our results exemplify the merits of AgNPs as PA imaging agents, providing a better understanding of the nanoengineering of new imaging probes and thereby extending the applications of AgNPs beyond traditional antimicrobial and wound healing applications. Since some of the nanoconstructs we explored in this study are currently being investigated as photothermal agents in clinical trials, new opportunities may arise in intraoperative imaging and image-guided therapy.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 19","pages":" 6110-6119"},"PeriodicalIF":4.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic activity of silver nanoparticles and antibiotics: apramycin against Escherichia coli","authors":"Ana C. Gimenez-Ingalaturre, Isabel Abad-Álvaro, Patricia Chueca, Pilar Goñi and Francisco Laborda","doi":"10.1039/D5NA00404G","DOIUrl":"10.1039/D5NA00404G","url":null,"abstract":"<p >The combination of silver nanoparticles and conventional antibiotics could be a promising alternative strategy to fight against antimicrobial resistance. The occurrence of synergistic bactericidal activity between these combinations is supported by a large number of studies, but there is still a great lack of information about the action mechanisms. In this study, a direct analytical method for the detection and quantification of silver content in cells based on single cell inductively coupled plasma mass spectrometry (SC-ICP-MS), in combination with microscopy and microbiological techniques, has been used. Quantification of silver accumulated in <em>Escherichia coli</em> bacteria exposed to combinations of silver(<small>I</small>) or silver nanoparticles and apramycin can help elucidate the synergistic mechanisms of silver–antibiotic combinations. The combination of silver with apramycin resulted in the occurrence of synergistic effects, allowing the reduction of silver(<small>I</small>), silver nanoparticle and apramycin concentrations (from 4- to 16-fold) while preserving the individual bactericidal effects of each antimicrobial. Severe damage in bacteria walls, including double membrane rupture and cytoplasm leakage, was observed when the combination of apramycin and silver was used. In general, the presence of apramycin has promoted silver uptake by bacteria.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 19","pages":" 6120-6131"},"PeriodicalIF":4.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12368801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-friendly fabrication of hydrophobic and breathable nanofibrous membranes via molecularly engineered WPU/PAM composites","authors":"Li Wang, Fajun Peng, Di Jin, Sen Fang and Yan Wang","doi":"10.1039/D5NA00467E","DOIUrl":"10.1039/D5NA00467E","url":null,"abstract":"<p >As demands increase for multifunctional textiles and breathable coatings in high-humidity and high-mobility environments, the development of membranes that combine waterproofing, breathability, and mechanical durability has become a critical challenge. This study presents a novel, organic solvent-free electrospinning approach to fabricate waterborne polyurethane (WPU)-based nanofiber membranes, enhanced by polyacrylamide (PAM) as a dual-functional additive. By leveraging hydrogen bonding interactions between the –COO<small>⁻</small>, –NHCOO– groups in WPU and the –CONH<small>₂</small> groups in PAM, the resulting composite achieved stable electrospinning, improved fiber morphology, and a significantly higher water contact angle (86.9°), compared to conventional WPU/PVA systems (&lt;10°). The optimized WPU/PAM-3 membrane maintained high air permeability and excellent tensile strength, while also showing low water absorption (∼18%) and strong structural stability under thermal, mechanical, and environmental cycling. Structural analyses <em>via</em> FTIR, XRD, and XPS confirmed enhanced interfacial compatibility and molecular interaction. Notably, this work eliminates the need for volatile organic solvents and hygroscopic additives like PVA, solving common limitations in traditional WPU systems. The resulting membrane offers a sustainable, high-performance solution for protective textiles, medical materials, and flexible barrier coatings, marking a significant advancement in eco-friendly, breathable membrane technology.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 19","pages":" 6239-6247"},"PeriodicalIF":4.6,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferrocene-based covalent organic framework-carbon nanotube hybrid modified with Cu(OAc)2 as a robust catalyst for the preparation of tetrazoles","authors":"Zahra Alishahi, Mohammad Ali Zolfigol, Saeid Azizian, Morteza Torabi and Yanlong Gu","doi":"10.1039/D5NA00566C","DOIUrl":"10.1039/D5NA00566C","url":null,"abstract":"<p >The emergence of covalent organic framework-carbon nanotube hybrid composites (COF-CNT) has opened up a promising approach for the development of heterogeneous catalysis. In this research, a new ferrocene-based COF was wrapped onto the surface of a carbon nanotube and modified with Cu(OAc)<small>₂</small> (denoted as FCOF-CNT-Cu(OAc)<small>₂</small>) for boosting the catalytic performance for the preparation of tetrazoles. Ferrocene segments played a decisive role in assisting Cu(OAc)<small>₂</small> as catalytically active sites for the preparation of 5-substituted 1<em>H</em>-tetrazoles and acrylonitrile-linked tetrazoles. FCOF-CNT-Cu(OAc)<small>₂</small> had a high specific surface area of 117 m<small>²</small> g<small>⁻¹</small>, which accelerated the catalytic process. Field emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM) analyses revealed that the catalyst was ordered with a tubular morphology and spherical COF grown on the outer surface of the CNT. This work presents FCOF-CNT-Cu(OAc)<small>₂</small> as a superior catalyst toward the preparation of 5-substituted 1<em>H</em>-tetrazoles and acrylonitrile-linked tetrazole derivatives. Consequently, tetrazole derivatives were synthesized in short reaction times under green and mild reaction conditions.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 19","pages":" 6084-6097"},"PeriodicalIF":4.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12366523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Halogen bonding-guided growth of heteroatom-rich polycarbazole wires on Au(111)","authors":"Frank Palmino, Vincent Luzet, Judicaël Jeannoutot, Alain Rochefort and Frédéric Chérioux","doi":"10.1039/D5NA00708A","DOIUrl":"10.1039/D5NA00708A","url":null,"abstract":"<p >The growth of conjugated polymers has been widely investigated on metal surfaces in ultrahigh vacuum. Here, we report that pre-organized halogen-bonded templates, based on a selecting bent molecular geometry, enable the on-surface synthesis of long, defect-free polycarbazole wires, laterally decorated with nitrogen-bound substituents as revealed by scanning tunnelling microscopy.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 19","pages":" 5951-5955"},"PeriodicalIF":4.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbon quantum dot-based fluorometric detection of nitrosamine impurities in active pharmaceutical ingredients","authors":"Gayathri Loganathan, Pirangi Srikanth, Khaja Moinuddin Shaik and Sukhendu Nandi","doi":"10.1039/D5NA00490J","DOIUrl":"10.1039/D5NA00490J","url":null,"abstract":"<p >Nitrosamines are genotoxic, mutagenic impurities and are widely encountered in the global landscape of the pharmaceutical industry. There is a need for rapid detection of nitrosamines in a pharmaceutical product. Here, we report the synthesis of carbon quantum dots (CQDs) using a readily available carbon precursor. These CQDs showed attractive fluorescence properties and were employed to fabricate a portable device for the fluorometric detection of nitrosamine impurities in a drug matrix.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 20","pages":" 6412-6416"},"PeriodicalIF":4.6,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel advancements in nanomaterials-based contrast agents across multimodal imaging and theranostic applications.","authors":"Harshita Tiwari, Swati Singh, Rajiv Kumar, Abhijit Mandal, Abhishek Pathak, Navin Kumar Verma, Lalit Kumar, Vibhav Gautam","doi":"10.1039/d5na00596e","DOIUrl":"10.1039/d5na00596e","url":null,"abstract":"<p><p>Nanomaterials offer significant potential for non-invasive multimodal imaging due to their multifunctionality and tunable nanoscale features. Advances in their design and conjugation with organic and inorganic materials have enhanced their production and utility. Functionalizing nanoparticles (NPs) with imaging agents enables high-contrast imaging with spatial precision. Plasmonic NPs, lanthanide NPs, semiconductor-based quantum dots (QDs), and biogenic NPs have been employed as contrast agents for sensitive and specific imaging. Diseases such as cancer, neurological, gastrointestinal, and cardiovascular conditions demand early diagnosis for effective therapy. Therefore, functionalized NPs are employed to enhance molecular imaging by penetrating cells and targeting biomolecules thereby improving imaging modalities like positron emission tomography (PET), X-ray computed tomography (CT), near-infrared fluorescence (NIRF), magnetic resonance imaging (MRI), and photoacoustic imaging (PAI). This review highlights novel NP applications for image-guided surgery and treatment, emphasizing their role in combining imaging techniques for precision diagnostics. Challenges such as clinical translation and toxicity are discussed, underscoring the need for further research. NP-based contrast agents have emerged as an effective tool for bridging the gap between traditional diagnostics and personalized treatments, enabling real-time therapeutic monitoring and early stage theranostics.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12455492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145138220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anomalous Raman signals in multilayer hexagonal boron nitride grown by chemical vapour deposition on metal foil catalysts.","authors":"Takara Okonai, Pablo Solís-Fernández, Satoru Fukamachi, Haiming Sun, Yeri Lee, Yung-Chang Lin, Toshiaki Kato, Sunmin Ryu, Kazu Suenaga, Hiroki Ago","doi":"10.1039/d5na00283d","DOIUrl":"10.1039/d5na00283d","url":null,"abstract":"<p><p>Hexagonal boron nitride (hBN), a two-dimensional (2D) wide bandgap material, serves as an ideal insulating substrate and a protection layer for other 2D materials, such as graphene and transition metal dichalcogenides (TMDs). Here, we report for the first time the emergence of an anomalous Raman peak in single-crystal, multilayer pyramidal hBN grains grown on Fe-Ni alloy foil by chemical vapour deposition (CVD). This peak is located near the characteristic E_2g band (1367 cm^-1) and shifts to higher wavenumbers with the increasing number of hBN layers, peaking at ∼1415 cm^-1 at the centre of hBN grains. The appearance of this Raman peak is attributed to a blue shift of the E_2g phonon caused by compressive strain induced during the cooling step in the CVD process. Triangular hBN grains are epitaxially grown on the alloy catalyst and hence are strongly affected by the volume change of the Fe-Ni alloy catalyst and by lateral compression induced by the steps of the Fe-Ni surface. The maximum strain calculated from the peak shift is -1.23%, which is much higher than the values previously reported for strained hBN, indicating a strong impact of the metal catalyst on the growing hBN structure. These results demonstrate the feasibility of strain engineering in hBN <i>via</i> CVD growth.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12434615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}