Oleg Yeshchenko, Léa Daoud, Pavlo Khort, Oles Fedotov, Julien-Bilal Zinoune, Georges Boudebs, Tony Breton, Catherine Passirani, Patrick Saulnier and Oksana Krupka
{"title":"Plasmonic behaviour of poly(2-ethyl-2-oxazoline)-coated gold nanoparticles for sensing and temperature-control applications†","authors":"Oleg Yeshchenko, Léa Daoud, Pavlo Khort, Oles Fedotov, Julien-Bilal Zinoune, Georges Boudebs, Tony Breton, Catherine Passirani, Patrick Saulnier and Oksana Krupka","doi":"10.1039/D5NA00243E","DOIUrl":"10.1039/D5NA00243E","url":null,"abstract":"<p >Gold nanoparticles functionalized with xanthate-poly(2-ethyl-2-oxazoline) (PEtOx-AuNPs) were investigated as thermoresponsive hybrid nanomaterials with tunable optical and thermal properties. The PEtOx-AuNPs exhibited changes in surface plasmon resonance (SPR) and amplified Surface-Enhanced Raman Scattering (SERS) signals during the reversible lower critical solution temperature (LCST) transition of the PEtOx ligand. The effect of the PEtOx coating on the photophysical properties of AuNPs, particularly on heat generation efficiency upon photoexcitation by Z-scan photothermal lens spectroscopy, was investigated. The results demonstrate the potential of PEtOx-AuNPs for applications in temperature-sensitive drug delivery, photothermal therapy, nanoscale heat generation, and photonic devices.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 13","pages":" 4018-4023"},"PeriodicalIF":4.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Debashree Roy, Helen C Larson, Brandi M Cossairt, Liane M Moreau
{"title":"Connecting the nanoseed defect structure and crystallinity with resulting nanoparticle products.","authors":"Debashree Roy, Helen C Larson, Brandi M Cossairt, Liane M Moreau","doi":"10.1039/d5na00418g","DOIUrl":"10.1039/d5na00418g","url":null,"abstract":"<p><p>Anisotropic gold (Au) nanocrystals (NCs) represent an interesting class of materials due to their shape and size dependent tunable optical properties as well as facet dependent catalytic and photocatalytic properties. The morphology of anisotropic Au NCs synthesized <i>via</i> the versatile seed-mediated synthesis is considered to be heavily dependent on the crystallinity and defect structure associated with the initial seed, modified in conjunction with surfactants and/or other shape-directing agents. The seeds can be considered as templates having well defined internal structure and crystal facets on which further atom deposition takes place <i>via</i> heterogeneous nucleation. While defect-structure directed morphological control has been established, the correlation of the seed crystal facets with the final morphology of Au NCs is rarely emphasized. In this study, we draw direct parallels between the crystal structure of the seed and the final morphology of Au NCs. We investigate this area by starting with seeds that have the same dominant crystal structure {111} but with four different morphologies and defect structures. Surprisingly, all the structures led to similar stellated NC products. Our findings open new avenues to evaluate NCs synthesized with seeds containing other crystal facets and exercise morphological control over Au NCs.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12146894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Praveen Kumar Kanti, Prashantha Kumar H G, V. Vicki Wanatasanappan, Abhinav Kumar and Melkamu Biyana Regasa
{"title":"Graphene's Frontier in aerospace: current applications, challenges, and future directions for space engineering","authors":"Praveen Kumar Kanti, Prashantha Kumar H G, V. Vicki Wanatasanappan, Abhinav Kumar and Melkamu Biyana Regasa","doi":"10.1039/D4NA00934G","DOIUrl":"10.1039/D4NA00934G","url":null,"abstract":"<p >Graphene is suitable for aerospace and space engineering because its single carbon layer exhibits excellent mechanical, electrical and thermal characteristics. Its tensile strength, which exceeds that of steel by 100 times, together with its high conductivity and thermal stability position graphene as an effective performance booster for spacecraft systems. Herein, we examine how graphene serves different space-based functions, starting with reinforcement supports and moving to thermal applications and radiative safety, before investigating energy storage methods. Since graphene has a very low weight, it serves as an excellent material to lower spacecraft weight, which consequently enhances fuel consumption and payload transportation. Graphene shows unique advantages by supporting composite structures and controlling heat in critical systems to adapt to the complex operating conditions in space. Graphene-based power systems, ranging from supercapacitors to batteries, provide high stored energy and long battery life for long space missions. However, many barriers slow the progress of graphene, including the production of large amounts at low cost with stability under harsh space conditions. Scientists are exploring ways to tackle the challenges associated with graphene while incorporating composite materials to design better spacecraft. Space exploration will progress further because improvements in graphene technology have created better spacecraft materials that resist damage.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 12","pages":" 3603-3618"},"PeriodicalIF":4.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenchao Zhao, Xiaowei Lv, Qianqian Xu, Zhengji Wen, Yuchuan Shao, Changlong Liu and Ning Dai
{"title":"Multifunctional terahertz metamaterials device based on a dual-tunable structure incorporating graphene and vanadium oxide","authors":"Wenchao Zhao, Xiaowei Lv, Qianqian Xu, Zhengji Wen, Yuchuan Shao, Changlong Liu and Ning Dai","doi":"10.1039/D5NA00278H","DOIUrl":"10.1039/D5NA00278H","url":null,"abstract":"<p >This paper presents a multifunctional terahertz device based on a dual-tunable structure incorporating graphene and vanadium oxide (VO<small><sub>2</sub></small>). This device enables the switching between narrowband perfect absorption and ultra-broadband performance through the phase transition characteristics of VO<small><sub>2</sub></small> and the adjustment of graphene Fermi level. Simulation results demonstrate that when VO<small><sub>2</sub></small> is in its metallic state, the THz device exhibits ultra-broadband absorption, achieving a high absorption rate exceeding 0.9 within the frequency range of 2.9–7.67 THz. Conversely, when VO<small><sub>2</sub></small> is in its insulating state, the THz device displays perfect absorption peaks at 2.8 and 8.41 THz. In the broadband mode, the absorption band can be broadened to an ultra-broadband range by adjusting the Fermi level of graphene. Furthermore, the structural parameters of terahertz devices, as well as the incident and polarization angles of electromagnetic waves, were investigated. The results demonstrated that the terahertz devices exhibit a certain degree of manufacturing tolerance, stability against variations in incident angles, and favorable polarization insensitivity. Overall, this design holds promising application prospects in fields such as terahertz absorption, refractive index sensing, and terahertz detection.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 12","pages":" 3817-3827"},"PeriodicalIF":4.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Sirichandana, R. Silviya, S. Venkataprasad Bhat, Nainesh Patel and Gurumurthy Hegde
{"title":"Biomass-derived carbon supported cobalt-phospho-boride as a bifunctional electrocatalyst for enhanced alkaline water splitting†","authors":"B. Sirichandana, R. Silviya, S. Venkataprasad Bhat, Nainesh Patel and Gurumurthy Hegde","doi":"10.1039/D5NA00213C","DOIUrl":"10.1039/D5NA00213C","url":null,"abstract":"<p >Developing efficient and low-cost bifunctional electrocatalysts for overall water splitting in order to reduce the future energy crisis is crucial and challenging. Herein, a facile two-step fabrication <em>via</em> pyrolysis and chemical reduction was used for the synthesis of biomass-derived carbon-based electrocatalyst (MT) from mulberry bark and its subsequent modification with cobalt phospho-boride (MT/CoPB) for efficient bifunctional electrocatalysis in alkaline media. The effect of <em>B</em>/<em>P</em> ratios and carbon-to-metal ratios on electrocatalytic performance of HER was investigated. Notably, the optimized MT/CoPB catalyst (<em>B</em>/<em>P</em> = 5, C : M = 2 : 1) exhibited a lower overpotential of −86 mV for HER and 310 mV for OER to reach the current density of 10 mA cm<small><sup>−2</sup></small>. The robust electrocatalytic performance of MT/CoPB towards the HER and OER was attributed to the combined effect of carbon and CoPB. Notably, it achieved a low cell voltage of 1.59 V to reach a current density of 10 mA cm<small><sup>−2</sup></small>, also maintaining reliable long-term stability. Characterization studies revealed that the enhanced performance was due to the amorphous structure of the catalyst, high electrochemical surface area, and efficient charge transfer. This work demonstrates the potential of biomass-derived carbon-based materials in the development of cost-effective and durable electrocatalysts for water splitting and green hydrogen production.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 13","pages":" 4056-4066"},"PeriodicalIF":4.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Copper(ii) complex-decorated ZrFe2O4 nanoparticles as a recyclable magnetic nanocatalyst for synthesis of N-containing heterocycles†","authors":"Tara Miladi and Masoomeh Norouzi","doi":"10.1039/D4NA01058B","DOIUrl":"10.1039/D4NA01058B","url":null,"abstract":"<p >In this study, a novel and magnetic nanocatalyst [ZrFe<small><sub>2</sub></small>O<small><sub>4</sub></small>@SiO<small><sub>2</sub></small>@GLYMO-oPD-Cu(<small>II</small>)] was developed by immobilization of an <em>o</em>-phenylenediamine–copper complex on ZrFe<small><sub>2</sub></small>O<small><sub>4</sub></small>@SiO<small><sub>2</sub></small> nanoparticles. The as-prepared nanocatalyst was identified by physicochemical techniques such as FT-IR, BET, SEM, VSM, XRD, TEM, TGA, DSC, ICP EDX, and EDX elemental mapping. This nanocomposite exhibited remarkable efficiency in promoting the green synthesis of nitrogen-rich heterocycles, including 5-substituted 1<em>H</em>-tetrazoles and 2,3-dihydroquinazolin-4(1<em>H</em>)-one derivatives, through click and cyclization reactions, respectively. The reactions were conducted under mild conditions, affording high yields in short reaction times. Furthermore, the catalyst demonstrated excellent stability and reusability, with minimal copper leaching observed across multiple catalytic cycles.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 13","pages":" 4104-4116"},"PeriodicalIF":4.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ilaria Zanoni, Sara Amadori, Andrea Brigliadori, Anna Luisa Costa, Simona Ortelli, Pierluigi Giacò, Costanza Baldisserotto, Simonetta Pancaldi and Magda Blosi
{"title":"Hybrid materials for wastewater treatment: synergistic coupling of Neochloris oleoabundans and TiO2 nanoparticles†","authors":"Ilaria Zanoni, Sara Amadori, Andrea Brigliadori, Anna Luisa Costa, Simona Ortelli, Pierluigi Giacò, Costanza Baldisserotto, Simonetta Pancaldi and Magda Blosi","doi":"10.1039/D5NA00236B","DOIUrl":"10.1039/D5NA00236B","url":null,"abstract":"<p >In this work, we combined microalgae's sorptive properties with titania-based nanoparticles' photocatalytic capabilities to develop technologies applicable to wastewater treatment while also providing valuable insights into the innovation of adsorption technologies. The coupling of <em>Neochloris oleoabundans</em> biomass with an inorganic nanophase enables the formation of hybrid materials integrating heavy metal adsorption with photocatalytic action. To prepare the samples, we employed a water-based colloidal method followed by a spray freeze granulation treatment. The preparation process was followed by comprehensive physicochemical characterization from the wet precursors to the final hybrid granules. Key performance indicators, including adsorption and photocatalytic activity, were assessed using two model contaminants: copper ions (for heavy metal adsorption) and Rhodamine B (for photocatalysis). The results revealed a synergistic effect of the hybrid nanomaterials, significantly enhancing the Cu<small><sup>2+</sup></small> adsorption capacity of the biomass, which increases from 30 mg g<small><sup>−1</sup></small> to 250 mg g<small><sup>−1</sup></small> when coupled with the inorganic phase and is likely due to the supporting and dispersing role of the inorganic nanoparticles on the biomass. The adsorption experimental values followed the Freundlich isothermal model and pseudo-second-order kinetic model, indicating that the adsorption occurred primarily through a multimolecular layer adsorption process, consistent with chemisorption mechanisms. The photocatalytic performance of the inorganic counterpart was preserved when coupled with the microalgae, with TiO<small><sub>2</sub></small>–SiO<small><sub>2</sub></small>/biomass achieving complete Rhodamine B degradation within 1 hour.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 12","pages":" 3803-3816"},"PeriodicalIF":4.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Green synthesis and characterization of Blumea sinuata silver nanoparticles: antibacterial, antifungal, and antioxidant properties†","authors":"Umakant Pradhan, Jagdish Prasad Prajapati, Purusottam Majhi, Dibyasha Sahu, Rajesh Kumar Singh, Sadhucharan Mallick and Awadhesh Kumar Shukla","doi":"10.1039/D4NA01063A","DOIUrl":"10.1039/D4NA01063A","url":null,"abstract":"<p >The plant <em>Blumea sinuata</em> (Lour.) Merr. harbours high amounts of phytoconstituents, some of which have strong reduction and capping potential. Eco-friendly and nontoxic silver nanoparticles have been synthesized using the plant extract of <em>B. sinuata</em>. The formation of <em>B. sinuata</em> silver nanoparticles (BS-Ag<small><sub>2</sub></small>O NPs) was confirmed through various techniques. UV-visible spectroscopy revealed an absorbance band at 408 nm, Fourier transform infrared spectroscopy (FTIR spectroscopy) identified functional groups serving as stabilizing and capping agents, essential for the formation of silver nanoparticles, dynamic light scattering (DLS) measurement indicated that the nanoparticles had a mean hydrodynamic diameter of 102.50 nm, and the evaluated zeta potential for surface charge analysis of BS-Ag<small><sub>2</sub></small>O NPs was found to be −16.4 mV. High-resolution transmission electron microscopy (HRTEM) showed an average particle size of 7.98 nm, and X-ray diffraction (XRD) analysis confirmed the face-centred cubic (FCC) structure of Ag<small><sub>2</sub></small>O NPs. The antibacterial activity of BS-Ag<small><sub>2</sub></small>O NPs against phytopathogenic bacteria <em>Erwinia carotovora</em>, <em>Ralstonia solanacearum</em>, and <em>Xanthomonas oryzae</em> was assessed by the agar-well diffusion method. At 400 μg concentration of BS Ag<small><sub>2</sub></small>O NPs, the maximum zones of inhibition were 20.66 mm and 20.33 mm against <em>E. carotovora</em> and <em>R. solanacearum</em>, respectively. While a zone of inhibition of 14.33 mm was observed against <em>X. oryzae</em>. Biogenic BS-Ag<small><sub>2</sub></small>O NPs exhibited remarkable antifungal activity against phytopathogenic fungi, namely <em>Alternaria alternata</em>, <em>Aspergillus niger</em>, <em>Aspergillus flavus</em>, and <em>Fusarium oxysporum</em>. At a concentration of 1.5 mg mL<small><sup>−1</sup></small> BS-Ag<small><sub>2</sub></small>O NPs, the percentage of inhibition was 91.70, 62.65, 58.96, and 50.45 on the growth of <em>A. alternata</em>, <em>A. flavus</em>, <em>A. niger</em>, and <em>F. oxysporum</em>, respectively. The antioxidant activity of BS-Ag<small><sub>2</sub></small>O NPs was evaluated by 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) as well as 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods. The reported DPPH free radical scavenging activity was 25.85 ± 0.36% at 80 μg mL<small><sup>−1</sup></small> concentration of BS-Ag<small><sub>2</sub></small>O NPs, and in the case of ABTS, it was found to be 40.28% at 80 μg mL<small><sup>−1</sup></small> concentration of BS-Ag<small><sub>2</sub></small>O NPs.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 12","pages":" 3732-3745"},"PeriodicalIF":4.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Magnetically recoverable Fe3O4@chitosan@Ni2B: a bio-based catalyst for one-pot green and efficient synthesis of tetrahydrobenzo[b]pyrans†","authors":"Bashir Mashhourzad and Behzad Zeynizadeh","doi":"10.1039/D4NA01020E","DOIUrl":"10.1039/D4NA01020E","url":null,"abstract":"<p >This study investigates the development of a novel and environmentally friendly catalyst, Fe<small><sub>3</sub></small>O<small><sub>4</sub></small>@chitosan@Ni<small><sub>2</sub></small>B nanocomposite, for multicomponent reactions (MCRs). Chitosan (CS), a biopolymer, is used because it is biocompatible, abundant, and has functional groups that can be complexed with metals. Nickel boride (Ni<small><sub>2</sub></small>B) is used in hydrogenation reactions due to its catalytic properties. The magnetic properties of Fe<small><sub>3</sub></small>O<small><sub>4</sub></small> nanoparticles enable easy separation. Herein, we describe the successful synthesis of the Fe<small><sub>3</sub></small>O<small><sub>4</sub></small>@CS@Ni<small><sub>2</sub></small>B nanocomposite and its use in MCRs for the green synthesis of tetrahydrobenzo[<em>b</em>]pyran derivatives. These heterocyclic compounds impress with their diverse biological activities. The research has several advantages, including the implementation of environmentally friendly catalyst protocols, the simplification and cost-effectiveness of the synthesis process, the use of an easily accessible biopolymer, the successful performance of efficient one-pot reactions without additional waste generation, and the easy recycling of the catalyst. This research demonstrates the potential of Fe<small><sub>3</sub></small>O<small><sub>4</sub></small>@CS@Ni<small><sub>2</sub></small>B as a promising catalyst for sustainable and selective MCRs.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 12","pages":" 3701-3721"},"PeriodicalIF":4.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144001983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marco Ricci, Fabio Carniato, Alessia Corrado, Giuseppe Ferrauto, Enza Di Gregorio, Giovanni Battista Giovenzana and Mauro Botta
{"title":"Comprehensive relaxometric analysis of Fe(iii) coordination polymer nanoparticles for T1-MRI: unravelling the impact of coating on contrast enhancement†","authors":"Marco Ricci, Fabio Carniato, Alessia Corrado, Giuseppe Ferrauto, Enza Di Gregorio, Giovanni Battista Giovenzana and Mauro Botta","doi":"10.1039/D5NA00250H","DOIUrl":"10.1039/D5NA00250H","url":null,"abstract":"<p >Coordination polymer-based systems, particularly Fe(<small>III</small>)-based polymers, are attracting increasing interest due to their well-controlled morphology, biocompatibility, and versatile surface functionalization. With five unpaired electrons, Fe(<small>III</small>) offers a promising and safer alternative to Gd(<small>III</small>) for MRI applications. While some studies have investigated low molecular weight Fe(<small>III</small>) chelates for MRI, the exploration of Fe(<small>III</small>)-based nanosystems as <em>T</em><small><sub>1</sub></small> MRI probes remains limited. This study focuses on the synthesis of Fe(<small>III</small>)/gallic acid nanoparticles functionalized with a low molecular weight polyethylene glycol (PEG) shell, designed to enhance the second-sphere water interaction and improve <em>r</em><small><sub>1</sub></small> relaxivity at clinical magnetic fields. The <small><sup>1</sup></small>H NMR relaxometric properties of these nanoparticles were systematically analyzed as a function of proton Larmor frequencies and temperature, and their performance was compared with a similar system stabilized by polyvinylpyrrolidone (PVP). We aimed to determine the frequency dependence of relaxivity in Fe(<small>III</small>)-based coordination polymers, and to assess the impact of coating modifications on their MRI contrast efficacy. This knowledge is crucial for the rational design of improved Fe(<small>III</small>)-based nanoprobes, allowing for optimized performance in future MRI applications.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 12","pages":" 3792-3802"},"PeriodicalIF":4.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}