Nanoscale Advances最新文献

{"title":"Revolutionizing cancer therapy: nanoformulation of miRNA-34 – enhancing delivery and efficacy for various cancer immunotherapies: a review","authors":"Marola Paula Fawzy, Hatem A. F. M. Hassan, Nada K. Sedky, Mohamed S. Nafie, Rana A. Youness and Sherif Ashraf Fahmy","doi":"10.1039/D4NA00488D","DOIUrl":"10.1039/D4NA00488D","url":null,"abstract":"<p >Despite recent advancements in cancer therapies, challenges such as severe toxic effects, non-selective targeting, resistance to chemotherapy and radiotherapy, and recurrence of metastatic tumors persist. Consequently, there has been considerable effort to explore innovative anticancer compounds, particularly in immunotherapy, which offer the potential for enhanced biosafety and efficacy in cancer prevention and treatment. One such avenue of exploration involves the miRNA-34 (miR-34) family, known for its ability to inhibit tumorigenesis across various cancers. Dysregulation of miR-34 has been observed in several human cancers, and it is recognized as a tumor suppressor microRNA due to its synergistic interaction with the well-established tumor suppressor p53. However, challenges have arisen with the therapeutic application of miR-34a. These include its susceptibility to degradation by RNase in serum, limiting its ability to penetrate capillary endothelium and reach target cells, as well as reports of immunoreactive adverse reactions. Furthermore, unexpected side effects may occur, such as the accumulation of therapeutic miRNAs in healthy tissues due to interactions with serum proteins on nano-vector surfaces, nanoparticle breakdown in the bloodstream due to shearing stress, and unsuccessful extravasation of nanocarriers to target cells owing to interstitial fluid pressure. Despite these challenges, miR-34a remains a promising candidate for cancer therapy, and other members of the miR-34 family have also shown potential in inhibiting tumor cell proliferation. While the <em>in vivo</em> applications of miR-34b/c are limited, they warrant further exploration for oncotherapy. Recently, procedures utilizing nanoparticles have been developed to address the challenges associated with the clinical use of miR-34, demonstrating efficacy both <em>in vitro</em> and <em>in vivo</em>. This review highlights emerging trends in nanodelivery systems for miR-34 targeting cancer cells, offering insights into novel nanoformulations designed to enhance the anticancer therapeutic activity and targeting precision of miR-34. As far as current knowledge extends, no similar recent review comprehensively addresses the diverse nanoformulations aimed at optimizing the therapeutic potential of miR-34 in anticancer strategies.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11414826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142291508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effect of Zn-AgIn5S8/CdS Z-scheme heterojunction and S-doped rGO for efficient removal of chromium from contaminated water","authors":"Soumya Mishra, Naresh Sahoo, Satyanjib Sahoo, Prasanta Kumar Sahoo, Prangya Ranjan Rout, Goutam Rath","doi":"10.1039/d4na00350k","DOIUrl":"https://doi.org/10.1039/d4na00350k","url":null,"abstract":"This study aimed to synthesize a Zn-AgIn5S8/CdS/SrGO nanocomposite for Cr (VI) removal from contaminated water under solar irradiation. To prevent photo corrosion of CdS, a Z-scheme heterojunction was formed between CdS and Zn-AgIn5S8. The introduction of Ag2+ plasmonic materials extended the light absorption range and stabilized the photocatalyst. Further, to improve the catalytic surface area, electrical conductivity, and minimize the rate of electron and hole pair recombination, the Zn-AgIn5S8/CdS Z-scheme heterojunction was loaded onto S-doped rGO. The morphological and structural analysis of the synthesized nanomaterials (NMs) was done using various techniques, including XRD, FT-IR, UV-VIS DRS, FESEM, TEM, EDAX, photoluminescence, and Raman spectroscopy. Results revealed that the Zn-AgIn5S8/CdS/SrGO nanocomposite removed 85% of Cr (VI) at an initial concentration of 50 mg/L in 180 min when exposed to solar irradiation. The simulated first-order kinetic model fitted to the experimental data for Cr (VI) reduction by the nanocomposite exhibits a high correlation coefficient (R2 ≥ 0.97) and the Kapp value for Zn-AgIn5S8/CdS/SrGO (Kapp = 0.0114 min-1) is around 1.6 times larger than that of bare ZnAgIn5S8. Moreover, Zn-AgIn5S8/CdS/SrGO heterojunctions show excellent reusability up to 4 cycles. Further, the possible photocatalytic mechanism of Cr (VI) reduction has been proposed. Therefore, the Zn-AgIn5S8/CdS/SrGO nanocomposite could serve as an alternative photocatalyst system driven by solar light for Cr (VI) reduction.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A highly reactive soybean oil-based superhydrophobic polyurethane film with long-lasting antifouling and abrasion resistance†","authors":"Junming Huang, Genzheng Sha, Minghui Cui, Mengqiu Quan, Yuqing Wang, Yao Lu, Jin Zhu and Jing Chen","doi":"10.1039/D4NA00674G","DOIUrl":"10.1039/D4NA00674G","url":null,"abstract":"<p >Superhydrophobic polyurethanes offer robust hydrophobicity and corrosion resistance. However, it is essential to consider the durability and environmental constraints associated with these materials. This study prepared a bio-based superhydrophobic polyurethane coating film using epoxidized soybean oil, superhydrophobically modified silica nanoparticles, and OH–PDMS–OH as surface modifiers. The coating film exhibited sustained super-hydrophobicity and an excellent antifouling effect for pu-erh tea and edible oils, among other substances, after 14 days of immersion in solutions with different pH values, 28 days of exposure to air, and 2000 abrasion cycles. This finding can be applied to the development of daily indoor and outdoor antifouling protective coatings and provides a new method for the preparation of green and durable superhydrophobic antifouling coating films.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/na/d4na00674g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photocatalytic activity of 2D copper porphyrin metal-organic framework for visible light overall water splitting","authors":"Andres Uscategui-Linares, Horatiu Szalad, Josep Albero, Hermenegildo Garcia","doi":"10.1039/d4na00594e","DOIUrl":"https://doi.org/10.1039/d4na00594e","url":null,"abstract":"A 2D cupper tetrakis (4-carboxyphenyl)prophyrin metal-organic framework has been prepared and used as photocatalyst for overall water splitting, measuring under visible light irradiation (λ&gt;450 nm) at one sun power a H2 production rate of 120 molH2 gcatalyst-1 h-1 that is among the highest ever reported. While the 2D Cu porphyrin MOF undergoes substantial degradation in 3 h upon UV irradiation (320-380 nm) exposed to the air, it appears to be photo stable under the conditions of the overall water splitting and visible light exposure, exhibiting similar temporal profiles for H2 and O2 evolution. Photocurrent experiments and band energy measurements indicates that the photocatalytic efficiency derives from an efficient charge separation in the visible region (apparent electron charge extraction efficiency at 540 nm of 0.1 %) and adequate alignment of the redox potential of the conduction (-0.59 V vs. NHE) and valence (+1.48 V vs. NHE) bands for water splitting.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications","authors":"Mostafa Ghafori Gorab, Hooman Aghamirza Moghim Aliabadi, Amir Kashtiaray, Mohammad Mahdavi, Milad Salimi Bani, Andisheh Etminan, Nabi Salehpour, Reza Eivazzadeh-Keihan and Ali Maleki","doi":"10.1039/D4NA90100B","DOIUrl":"10.1039/D4NA90100B","url":null,"abstract":"<p >Expression of concern for ‘Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications’ by Mostafa Ghafori Gorab <em>et al.</em>, <em>Nanoscale Adv.</em>, 2023, <strong>5</strong>, 153–159, https://doi.org/10.1039/D2NA00394E.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/na/d4na90100b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D nanoplasmonic structure for ultrahigh enhanced SERS with less variability, polarization independence, and multimodal sensing applied to picric acid detection†","authors":"Anand M. Shrivastav, Mohammad Abutoama and Ibrahim Abdulhalim","doi":"10.1039/D4NA00387J","DOIUrl":"10.1039/D4NA00387J","url":null,"abstract":"<p >Surface-enhanced Raman scattering (SERS) is recognized as a powerful analytical method. However, its efficacy is hindered by considerable signal variability stemming from factors like surface irregularities, temporal instability of the substrate, interference with substrate signal, polarization sensitivity and uneven molecular distribution. To address these challenges, a new strategy is employed to enhance the reproducibility of SERS signals. Initially, a periodic 3D metallic structure is utilized to achieve polarization-independent ultrahigh enhancement. Additionally, signal averaging over multiple points and normalization are implemented. The integration of these techniques enables multimodal sensing (SERS, SEF, SPR) using a plasmonic chip, demonstrating ultrahigh enhancement through the interaction of extended and localized plasmons alongside nanoantenna-type resonances. The chip comprises a periodic silver 2D grating adorned with Au nanocubes, behaving as a 3D metasurface to amplify plasmonic local fields, thus facilitating SERS. Its uniformity and polarization independence together with signal averaging and normalization mitigate signal variability. Fabricated <em>via</em> electron beam lithography, the chip's performance is evaluated for surface-enhanced fluorescence (SEF) and SERS using Rhodamine 6G as the target molecule. Results exhibit two orders of magnitude enhancement factor for SEF and 2.5 × 10<small>⁷</small> for SERS. For chemical sensing, the chip is tested for picric acid detection across a concentration range from nanomolar to millimolar, demonstrating a detection limit of approximately 3 nM.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/na/d4na00387j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailoring surface morphology on anatase TiO2 supported Au nanoclusters: implications for O2 activation","authors":"Muhammed Fasil Puthiyaparambath, Julian Ezra Samuel, Raghu Chathanathodi","doi":"10.1039/d4na00744a","DOIUrl":"https://doi.org/10.1039/d4na00744a","url":null,"abstract":"Strong interaction between the support surface and metal clusters activates the adsorbed molecules at the metal cluster-support interface. Using plane-wave DFT calculations, we precisely model the interface between anatase TiO<small>₂</small> and small Au nanoclusters. Our study focusses on the adsorption and activation of oxygen molecules on anatase TiO<small>₂</small>, considering the influence of oxygen vacancies and steps on the surface. We find that the plane (101) and the stepped (103) surface do not support O<small>₂</small> activation, but the presence of oxygen vacancies results in strong adsorption and O-O bond length dilation. Modifying the TiO<small>₂</small> surface with supported small Au<small>_n</small> nanoclusters (n = 3 - 5) also significantly enhances O<small>₂</small> adsorption and stretches the O-O bond. We observe that manipulating the cluster orientation through discrete rotations results in improved O<small>₂</small> adsorption and promotes charge transfer from the surface to the molecule. We propose that the orientation of the supported cluster may be manipulated by getting the cluster to adsorb at the step-edge of (103) TiO<small>₂</small>. This results in activated O<small>₂</small> at the cluster-support interface, with a peroxide-ranged bond length and a low barrier for dissociation. Our modeling demonstrates a straightforward means of exploiting the interface morphology for O<small>₂</small> activation under low precious metal loading, which has important implications for electrocatalytic oxidation reactions and the rational design of supported catalysts.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and application of minocycline polymer micelle thermosensitive gel in spinal cord injury","authors":"Jun Gu, Xiaohu Cai, Faisal Raza, Hajra Zafar, Bo Chu, Haitao Yuan, Tianqi Wang, Jiapeng Wang, Xiaojun Feng","doi":"10.1039/d4na00625a","DOIUrl":"https://doi.org/10.1039/d4na00625a","url":null,"abstract":"Neuroprotection is one important approach for treatment of spinal cord injury (SCI). Minocycline (MC), a known neuroprotective agent has been utilized for SCI treatment, but its therapeutic effect is limited by instability and low bioavailability. Herein, we sought to incorporate MC into polyethylene glycol (PEG)- poly (lactate-co-glycolic acid) (PGLA) co-polymer to form micelles, and subsequently micellar thermosensitive MC-loaded hydrogel (MCPP-M-gel) for application in rat model of SCI. After incorporation of MC into micellar system (MCPP-M) via thin film hydration method, it was physically characterized using encapsulation rate, zeta potential, polydispersed index (PDI) and particle size. Later, the micelles were developed into MCPP-M-gel and characterized with appropriate physico-mechanical properties. In vitro release testing was evaluated via diffusion method, while cytotoxicity was performed using neural-crest-derived ectoderm mesenchymal stem cells (EMSCs). Regarding results, controlled and prolonged MC release from MCPP-M-gel for 72 h was observed with the hydrogel exhibiting no cytotoxicity to EMSCs at the studied dose. Afterward, MC, MCPP-M, MCPP-M-gel and blank micellar thermosensitive gel were injected into the injured site of SCI rats. Histopathological evaluation demonstrated that MCPP-M-gel improved histological assessments which depicted that MCPP-M-gel could promote neuronal regeneration at the injured site of the SC after 28 days. Immunofluorescence techniques exhibited that MCPP-M-gel increased expression of neuronal class III β-tubulin (Tuj1), myelin-basic protein (MBP), growth associated protein 43 (GAP43), neurofilament protein-200 (NF-200) and Nestin, as well as reduced glial-fibrillary acidic protein (GFAP) expression in damaged areas of SC. This experimental work provides foundation for subsequent investigation and application of MCPP-M-gel in SCI models or other disorders of neurons.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.7,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing few-layered graphitic carbons with atomic-sized cobalt hydroxide by harnessing hollow metal–organic frameworks†","authors":"Eun Jin Cho, Bo-Min Kim, WooYeon Moon, Dong Gyu Park, Young-Wan Ju, Won Ho Choi and Jeeyoung Shin","doi":"10.1039/D4NA00203B","DOIUrl":"10.1039/D4NA00203B","url":null,"abstract":"<p >Graphitic carbon exhibits distinctive characteristics that can be modulated by varying the number of carbon layers. Here, we developed a method to control the growth of graphitic carbon layers through pyrolysis of zeolitic imidazolate frameworks (ZIFs). The key is to pyrolyze hollow-structured ZIF-8 containing Co ions to simultaneously obtain an amorphous carbon source for graphitic carbons and Co metal nanoparticles for catalyzing graphitization of amorphous carbons. Owing to sparsely distributed Co ions within ZIF-8, Co nanoparticles are formed, which leads to localized graphitization. The graphitic carbon obtained contained two to five layers, unlike carbonized ZIF-67. The few-layered graphitic carbon was subjected to KOH activation and employed as a support for atomic-sized Co(OH)<small>₂</small> owing to the short routes for Co nanoparticle egress and OH<small>⁻</small> ion movement. Our strategy does not involve any highly corrosive process for catalyst leaching and can even be used to produce atomic-sized Co(OH)<small>₂</small> with few-layered graphitic carbons.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/na/d4na00203b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmentally friendly PtNiCo nanocatalysts enhanced with multi-walled carbon nanotubes for sustainable methanol oxidation in an alkaline medium","authors":"Merve Akin, Anas El Attar, Ramazan Bayat, Muhammed Bekmezci, Badr Bouljoihel, Mama El Rhazi and Fatih Sen","doi":"10.1039/D4NA00274A","DOIUrl":"10.1039/D4NA00274A","url":null,"abstract":"<p >In this study, trimetallic PtNiCo/MWCNT and PtNiCo catalysts were synthesized using a microwave method to reduce the amount of precious Pt. The prepared catalysts were characterized using XRD, TEM, and EDX mapping and their electrochemical performances for methanol oxidation were investigated. The results showed that the MWCNT-supported catalyst showed 2.42 times higher electrochemical activity than the PtNiCo catalyst with a peak current density of 283.14 mA cm<small>⁻²</small> at −0.2 V potential. Moreover, in long-term stability tests, it exhibited high stability and 4.97 times higher current density at the end of 3600 s. The results showed that the MWCNT-supported catalyst offered improved electron transfer, 4.7 times higher surface area, and resistance to CO poisoning. These performance improvements due to the trimetallic structure are mostly thought to help accelerate the dehydrogenation of methanol. This study contains important findings for future functional catalyst design in the fields of catalysis and energy conversion.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2024/na/d4na00274a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}