Nanoscale Advances最新文献

{"title":"Effect of molecular adsorption on the conductivity of selectively grown, interconnected 2D-MoS2 atomically thin flake structures","authors":"Ionel Stavarache, Catalin Palade, Adrian Slav, Ioana Dascalescu, Ana-Maria Lepadatu, Elena Matei, Cristina Besleaga, Magdalena Lidia Ciurea, Beata E. Kardynal and Toma Stoica","doi":"10.1039/D5NA00138B","DOIUrl":"10.1039/D5NA00138B","url":null,"abstract":"<p >The gas sensitivity of field-effect structures with 2D-MoS<small>₂</small> channels selectively grown between Mo electrodes using the Mo-CVD method was investigated by measuring the effect of molecular adsorption from air on the device source-drain current (<em>I</em><small>_sd</small>). The channels were composed of interconnected atomically thin MoS<small>₂</small> grains, with their density and average thickness varied by choosing two different distances (15 and 20 μm) between the Mo contacts. A high response to the tested stimuli, including molecule adsorption, illumination and gate voltage changes, was observed. A significant, persistent photoconduction was induced by positive charge accumulation on traps, most likely at grain boundaries and associated defects. <em>I</em><small>_sd</small> increased under high vacuum, both in the dark and under illumination. The relative dark current response to the transition from air to high vacuum reached up to 1000% at the turn-on voltage. When monitored during the gradual change in air pressure, <em>I</em><small>_sd</small> exhibited a non-monotonic function, sharply peaking at about 10<small>⁻²</small> mbar, suggesting molecular adsorption on different defect sites and orientations of adsorbed H<small>₂</small>O molecules, which were capable of inducing electron accumulation or depletion. Despite the screening of disorder by extra electrons, the #20 μm sample remained more sensitive to air molecules on its surface. The high vacuum state was also investigated by annealing devices at temperatures up to 340 K in high vacuum, followed by measurements down to 100 K. This revealed thermally stimulated currents and activation energies of trapping electronic states assigned to sulfur vacancies (230 meV) and other shallow levels (85–120 meV), possibly due to natural impurities, grain boundaries or disorder defects. The results demonstrate the high sensitivity of these devices to molecular adsorption, making the technology promising for the easy fabrication of chemical sensors.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 8","pages":" 2368-2380"},"PeriodicalIF":4.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binding affinity and transport studies of engineered photocrosslinkable affibody-enzyme-nanoparticle constructs†","authors":"Shane D. Curry, Bryce M. Bower, Sven A. Saemundsson, Andrew P. Goodwin and Jennifer N. Cha","doi":"10.1039/D4NA00823E","DOIUrl":"10.1039/D4NA00823E","url":null,"abstract":"<p >Nanoparticle accumulation at tumor sites has been well reported <em>in vivo</em>, where targeting typically shows increased retention, but challenges remain for clinical translation. This work examines the effect of targeting ligand binding affinities and nanoparticle size on retention and transport through a solid tumor. We first show using cell affinity assays that modifying a wildtype (WT) anti-epidermal growth factor receptor (EGFR) affibody-enzyme fusion protein into a UV-photocrosslinkable (N23BP) version led to a significant decrease in affinity, whether as a free protein or as a conjugate to silica nanoparticles. Despite the reduced EGFR affinity, all protein conjugated nanoparticles showed binding and uptake to EGFR-overexpressing HTB9 bladder cancer cells as detected by confocal microscopy and flow cytometry. Next, transport studies of the protein conjugated nanoparticles using monoculture spheroids revealed that spheroid binding was higher for 17 nm particles bound with the WT proteins than N23BP, which was expected based on their respective <em>K</em><small>_D</small> values. However, the 17 nm particles conjugated with the photocrosslinkable N23BP affibody-enzymes showed an altered distribution profile that peaked further into the spheroid than the WT nanoparticle conjugates or in the absence of UV treatment. We correlate this finding with increased transport and retention of the photocrosslinked N23BP-nanoparticle conjugates in 3D spheroids to both the lower binding affinity of the affibodies for EGFR and the ability to introduce covalent linkages between the affibody and cell receptor. The larger 40 nm protein-conjugated nanoparticles showed limited penetration regardless of affinity or photocrosslinking on a 12 h timescale but did show overall increased transport after 24 h.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 8","pages":" 2239-2247"},"PeriodicalIF":4.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dynamic broadband plasmonic absorber enabled by electrochemical lithium metal batteries†","authors":"Huiling Yu","doi":"10.1039/D4NA00950A","DOIUrl":"10.1039/D4NA00950A","url":null,"abstract":"<p >As plasmonic absorbers attract considerable attention in the fields of solar energy harvesting, sensors, and cloaking technology, achieving dynamic tuning holds promise for multifunctional applications. However, existing designs face challenges in achieving real-time dynamic regulation across the visible band. In this study, we propose an innovative approach to achieve dynamic broadband absorption at visible wavelengths <em>via</em> an electrochemical lithium metal battery. Through rigorous experimentation and simulation, we demonstrate that the dynamic absorber achieves remarkable reversibility, with 80% absorption at lithium deposition states and a 40% modulation amplitude in reflectance over 30 cycles. At the intersection of the plasmonic absorber and lithium battery, our results may provide insights for light detection such as the monitoring environment.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 8","pages":" 2322-2328"},"PeriodicalIF":4.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study on the synthesis strategies and electrochemical features of bimetallic Cu/Co-MOFs†","authors":"Mohan Rao Tamtam, Rui Wang, Ravindranadh Koutavarapu, Gyu Sang Choi, Jaesool Shim, Nguyen To Hoai and Nam Nguyen Dang","doi":"10.1039/D5NA00019J","DOIUrl":"10.1039/D5NA00019J","url":null,"abstract":"<p >In this work, three distinct synthetic procedures—step-by-step (CC-1), single-step (CC-2), and simple mixing (CC-3)—were utilized to investigate their effects on the formation of heterostructures in bimetallic Cu/Co-MOFs. The resulting MOF crystal structures revealed a 1 : 1 ratio of Co to Cu metal ions, and compared their electrochemical activities with a simple mixture of individual MOFs. To maximize the benefits of these synthesis approaches for supercapacitor uses, electrochemical analyses were conducted. Results revealed that the capacitance of CC-1 was 438 F g<small>⁻¹</small> at 1 A g<small>⁻¹</small>, which was 1.14 times and 2.76 times higher than those of the CC-2 and CC-3 samples, respectively. This notable performance was attributed to the synergistic contributions from each 2D material component and the formation of a stable heterostructure that resulted from an optimal metal-ion loading. The best-performing CC-1 electrode was further tested in both asymmetric (AD) and symmetric (SD) coin cell devices. AD demonstrated an energy density (ED) of 40.4 W h kg<small>⁻¹</small> through a power density (PD) of 302.3 W kg<small>⁻¹</small> with 75% stability, while the SD device displayed an ED of 15.7 W h kg<small>⁻¹</small> and a PD of 346.7 W kg<small>⁻¹</small> with 88% stability.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 9","pages":" 2585-2598"},"PeriodicalIF":4.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced electrochemical sensing of methyl parathion using AgNPs@IL/GO nanocomposites in aqueous matrices†","authors":"Saddam Weheabby, Ziyuan Liu, Igor A. Pašti, Vladimir Rajić, Marcio Vidotti and Olfa Kanoun","doi":"10.1039/D4NA00919C","DOIUrl":"10.1039/D4NA00919C","url":null,"abstract":"<p >Methyl parathion (MP) is a widely used pesticide; it is recognized as being toxic to both target and non-target species, posing serious risks to environmental and human health. Monitoring and controlling MP residues is thus essential, necessitating the development of innovative sensors that are highly sensitive, selective, and reproducible. In the present study, an efficient electrochemical MP sensor is proposed based on silver nanoparticles (AgNPs) in conjunction with graphene oxide/ionic liquid (GO/IL) on screen printed electrodes (AgNPs@GO/IL@SPCE). The AgNPs were synthesized <em>via</em> a cost-effective wet-chemical process and characterized using UV-Vis spectroscopy and transmission electron microscopy (TEM). The modified electrodes were characterized by scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX). The active surface area and charge transfer were examined by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), respectively. The modified electrodes' electrocatalytic performance towards the reduction of MP was investigated by CV, complemented by semiempirical quantum chemistry calculations to elucidate the interaction and the electrochemical reduction mechanism of MP. The sensor demonstrates a remarkable limit of detection of 0.009 μmol L<small>⁻¹</small> within a linear range of 0.025 to 200 μmol L<small>⁻¹</small>. It has an excellent analytical performance in terms of selectivity, reproducibility, and long-term stability over 60 days. The designed sensor was effectively used to inspect MP in groundwater and surface water samples, with recovery values ranging from 95.60% to 99.68%.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 8","pages":" 2195-2208"},"PeriodicalIF":4.6,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143502680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel synthesis approach for highly crystalline CrCl3/MoS2 van der Waals heterostructures unaffected by strain†","authors":"Mahmoud M. Hammo, Samuel Froeschke, Golam Haider, Daniel Wolf, Alexey Popov, Bernd Büchner, Michael Mertig and Silke Hampel","doi":"10.1039/D4NA00935E","DOIUrl":"10.1039/D4NA00935E","url":null,"abstract":"<p >Controlling the layer-by-layer chemistry and structure of nanomaterials remains a crucial focus in nanoscience and nanoengineering. Specifically, the integration of atomically thin semiconductors with antiferromagnetic two-dimensional materials holds great promise for advancing research. In this work, we successfully demonstrate a new synthesis approach for high-crystallinity CrCl<small>₃</small>/MoS<small>₂</small> van der Waals heterostructures <em>via</em> a thermodynamically optimized chemical vapor transport (CVT) process on <em>c</em>-sapphire (0001) substrates. The 2H-MoS<small>₂</small> layers can be grown as monolayers or with varying twist angles whereas the deposition of CrCl<small>₃</small> layers in a second step forms the well-defined heterostructure. Of particular significance are the sharp and clean edges and faces of the crystals, indicating high-quality interfaces in the heterostructures. Raman spectroscopy, AFM and HRTEM confirm the monocrystalline character and precise structure of these layered nanomaterials, in which their intrinsic properties are preserved and unaffected by strain. This can pave the way for next-generation applications, particularly in valleytronics, opto-spintronics, and quantum information processing.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 8","pages":" 2351-2359"},"PeriodicalIF":4.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction to carbon nanomaterials for smart applications","authors":"Zhenyuan Xia, Yeye Wen and Muqiang Jian","doi":"10.1039/D5NA90013A","DOIUrl":"10.1039/D5NA90013A","url":null,"abstract":"<p >A graphical abstract is available for this content</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 6","pages":" 1487-1488"},"PeriodicalIF":4.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of clopidogrel and clonidine interactions for cardiovascular formulations: progress from DFT modeling","authors":"B. Ocampo Cárdenas, G. Román, E. Noseda Grau and S. Simonetti","doi":"10.1039/D4NA00776J","DOIUrl":"10.1039/D4NA00776J","url":null,"abstract":"<p >The drugs clopidogrel and clonidine are frequently used to treat cardiovascular diseases, which are the leading cause of mortality worldwide. Since these medications are frequently taken in combination, it is crucial to examine their molecular interactions. Therefore, herein, the bandgap energy, chemical potential, chemical hardness and softness parameters were calculated using a density functional theory (DFT)-based method. In addition, infrared (IR) spectrum, natural bond orbital (NBO), molecular electrostatic potential (MEP), electron localization function (ELF) and total density of states (TDOS) plots complemented the analysis. Clonidine exhibited greater sensitivity to electrophilic attack, while the electronic affinity of clopidogrel was slightly higher. According to the MEP map, negative charge density was located on the oxygen atoms of clopidogrel, and the positive charge was located on the nitrogen atoms of clonidine. Notably, both the drugs exhibited similar reactivity in water. Clopidogrel was less reactive than clonidine, and the interaction between the molecules occurred <em>via</em> physisorption, which was in agreement with the TDOS plot. NBO analysis revealed a low charge variation, in accordance with the physical adsorption-like bonding between the drugs. The lowest energy for the clopidogrel–clonidine interaction was attained <em>via</em> the formation of four H bonds, as indicated by a significant intensive peak at 3360 cm<small>⁻¹</small> in the IR spectrum. Hydrogen bonds played a crucial role in the controlled drug delivery application as it allowed moderate and reversible drug adsorption, facilitating drug release in the biological environment. IR spectra also supported the absence of degradation or chemical reaction between the drugs, confirming the preservation of the individual active pharmaceutical ingredient.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 8","pages":" 2338-2350"},"PeriodicalIF":4.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel auxetic semiconductors with high carrier mobility: first principles prediction of Janus Ge2XY (X/Y = S, Se, Te) monolayers","authors":"Vo Q. Nha, Nguyen Q. San, Huynh T. T. Linh, Tuan V. Vu and Nguyen D. Hien","doi":"10.1039/D4NA00852A","DOIUrl":"10.1039/D4NA00852A","url":null,"abstract":"<p >Recently, auxetic materials have attracted attention due to their unusual behavior and multifunctional applications. A negative Poisson's ratio has been found in some two-dimensional (2D) asymmetric layered materials. In this work, we predict a new class of 2D auxetic materials with the chemical formula Ge<small>₂</small>XY (X/Y = S, Se, Te) using <em>ab initio</em> calculations. We construct the crystal structure and evaluate the stability of Janus Ge<small>₂</small>XY monolayers under ambient conditions. Phonon dispersion spectra, cohesive energy calculations, and molecular dynamics simulations confirm the high structural stability of Ge<small>₂</small>XY. At the ground state, Ge<small>₂</small>XY monolayers are semiconductors with narrow band gaps ranging from 0.11 to 1.09 eV. We also calculate the mechanical properties, including elastic constants, Young's modulus, and Poisson's ratio. Importantly, the Ge<small>₂</small>XY monolayers represent ideal auxetic materials with a large negative Poisson's ratio. All three Ge<small>₂</small>XY systems possess Poisson's ratio values of around −0.2 along the <em>x</em>-axis. Moreover, Ge<small>₂</small>XY monolayers are predicted to have high electron mobility up to 10.92 × 10<small>³</small> cm<small>²</small> V<small>⁻¹</small> s<small>⁻¹</small> (Ge<small>₂</small>STe). The combination of ideal auxetic behavior and tunable transport properties makes the Janus Ge<small>₂</small>XY structures promising materials for nanoelectronic and mechanical applications.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 8","pages":" 2301-2308"},"PeriodicalIF":4.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-activated nano-oxygen sensitizer for sonodynamic–radiotherapy of esophageal cancer†","authors":"Jiayin Liu, Manru Shi, Huijia Zhao, Xin Bai, Quan Lin, Xin Guan, Bolin Wu and Mingyan E.","doi":"10.1039/D5NA00042D","DOIUrl":"10.1039/D5NA00042D","url":null,"abstract":"<p > <em>Background</em>: owing to the intricate nature, variability, and persistent oxygen-deficient environment associated with esophageal cancer (EC) tissues, radiotherapy (RT) sometimes doesn't work as well because some cancer cells can resist the radiation to a certain extent. This can lead to the cancer coming back in the same spot or even making the treatment ineffective. The integration of RT with oxygenation strategies is a common approach in cancer treatment. The advent of oxygen-enhancing sonodynamic therapy (SDT), leveraging the cytotoxic effects of reactive oxygen species (ROS), has garnered significant attention as an innovative approach to inducing cell death. <em>Methods</em>: this study utilized nanobubbles (NBs) containing the acoustic sensitizer indocyanine green (ICG) to create a nanoplatform (ICG@O<small>₂</small> NBs) that incorporates oxygen-enhanced SDT and RT. Besides, NBs are paired with low-frequency ultrasound (LFUS), known as ultrasound-targeted nano-bubble destruction (UTND), for precise drug release and improved safety. <em>Results</em>: experimental findings, including JC-1/DCFH-DA assays, demonstrate that ICG@O<small>₂</small> NBs effectively enhance the performance of both RT and SDT. RNA sequencing (RNA-seq) demonstrated differential expression of mRNA and LncRNA prior to and after co-treatment. KEGG and GO pathway analysis were then conducted for enriching and recognizing target genes and pathways correlated with the sensitivity of RT, which were revealed to be remarkably clustered in RT-associated pathways. <em>Conclusion</em>: <em>in vitro</em> and <em>in vivo</em> investigations have indicated significant efficacy of synergistic treatments, highlighting the potential of combining NBs with SDT and RT for managing EC.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 8","pages":" 2209-2221"},"PeriodicalIF":4.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143502684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}