Nanoscale Advances最新文献_第6页

Protein corona composition modulates uptake of polymeric micelles by colorectal cancer cells. 蛋白质电晕组成调节大肠癌细胞对聚合物胶束的摄取。

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-06-23 DOI: 10.1039/d4na01085j

Munira Sirazum, Ahmed Abdelfattah, Prashant Pandey, Aliakbar Ashkarran, Soheyl Tadjiki, Shahriar Sharifi, Hassan Gharibi, Amir Ata Saei, Morteza Mahmoudi, Afsaneh Lavasanifar

{"title":"Protein corona composition modulates uptake of polymeric micelles by colorectal cancer cells.","authors":"Munira Sirazum, Ahmed Abdelfattah, Prashant Pandey, Aliakbar Ashkarran, Soheyl Tadjiki, Shahriar Sharifi, Hassan Gharibi, Amir Ata Saei, Morteza Mahmoudi, Afsaneh Lavasanifar","doi":"10.1039/d4na01085j","DOIUrl":"10.1039/d4na01085j","url":null,"abstract":"Protein corona formation on nanoparticles affects their biological interactions and fate. Polymeric micelles (PMs), preferred nanocarriers for poorly water-soluble drugs, have unclear behaviors in biological environments. This study examines the protein corona compositions of PMs formed from poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-PCL) and PEO-block-poly(α-benzyl carboxylate-ε-caprolactone) (PEO-PBCL) copolymers with varying degrees of polymerization after incubation in human plasma, and explores their relationship with cellular uptake by colorectal cancer cells. Traceable block copolymers were synthesized, self-assembled into PMs (44-99 nm, slightly negative zeta potentials), and characterized. Protein coronas were formed by incubating PMs with human plasma; protein-coated micelles were separated and analyzed. Uptake of selected PMs, with and without human plasma pre-incubation, by colorectal cancer cells was assessed. PEO-PCL micelles exhibited higher cellular uptake than PEO-PBCL micelles. Human plasma significantly reduced the uptake of PEO-PCL micelles, while PEO-PBCL micelles' uptake remained low. Proteomic analysis identified 23 distinct proteins among the combined top 20 most abundant proteins from each PM corona, with 18 common across all micelle types. In the top 10 proteins, PEO-PCL micelles shared an identical profile, whereas PEO-PBCL micelles had two unique proteins not present in PEO-PCL coronas. Protein corona composition in both PMs was shown to influence their cellular uptake behavior.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12215469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sublingual microrobotic pills for rapid and efficient drug delivery† 舌下微型机器人药丸，快速有效地给药。

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-06-23 DOI: 10.1039/D5NA00313J

Nelly Askarinam, Chuanrui Chen, Vivian Vo, Michael Casares, Kyra Wu, Ethan Shen, Majd Iskandarani, Víctor de la Asunción-Nadal, An-Yi Chang, Tomohiro Yamamoto, Janna Sofia Sage-Sepulveda, Baha Öndeş, Zhenning Zhou, Zike Yan, Jesse Qualliotine and Joseph Wang

{"title":"Sublingual microrobotic pills for rapid and efficient drug delivery†","authors":"Nelly Askarinam, Chuanrui Chen, Vivian Vo, Michael Casares, Kyra Wu, Ethan Shen, Majd Iskandarani, Víctor de la Asunción-Nadal, An-Yi Chang, Tomohiro Yamamoto, Janna Sofia Sage-Sepulveda, Baha Öndeş, Zhenning Zhou, Zike Yan, Jesse Qualliotine and Joseph Wang","doi":"10.1039/D5NA00313J","DOIUrl":"10.1039/D5NA00313J","url":null,"abstract":"Rapid drug delivery is critical in emergency medical circumstances where delays can result in adverse or life-threatening outcomes. The sublingual route holds significant promise for the swift systemic delivery of drugs, but is limited by slow passive diffusion mechanisms that hinder efficient drug transport. To address these challenges, we introduce here a novel sublingual microrobotic pill platform designed for rapid and efficient drug delivery. Our system incorporates magnesium-based microstirrers that accelerate pill disintegration and drug release via an active propulsion mechanism. Such bubble-propelled microstirrers generate strong hydrodynamic flows, enhancing local mixing and drug transport, allowing them to overcome the limitations of traditional diffusion-dominated delivery systems. Optimized through in vitro studies, this platform demonstrated robust motion capabilities in complex human saliva and accelerated drug release kinetics. In a rabbit model, using epinephrine as the model drug, the sublingual microrobotic pill achieved significantly faster drug delivery speed, efficiency, and bioavailability compared to a conventional pill. Moreover, when compared against the gold standard intramuscular injections, the microstirring pill provides competitive delivery speed and enhanced absorption profile, demonstrating its potential for use in the treatment of conditions like anaphylactic shock. Such user-friendly, non-invasive sublingual microrobotic pills can be readily employed for delivering a wide range of drugs, offering a versatile solution for acute conditions requiring rapid therapeutic onset or when enteral absorption is not feasible.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 15","pages":" 4730-4739"},"PeriodicalIF":4.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12199271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of ion intercalation materials on advancing capacitive deionization: from theory to practical 离子插入材料对推进电容性去离子的影响：从理论到实践。

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-06-19 DOI: 10.1039/D5NA00311C

Mahima S., Manjunatha Kumar K. S., Prajwal Sherugar, Xuezhu Xu, Gurunatha K. L., Mahesh Padaki and D. H. Nagaraju

{"title":"Impact of ion intercalation materials on advancing capacitive deionization: from theory to practical","authors":"Mahima S., Manjunatha Kumar K. S., Prajwal Sherugar, Xuezhu Xu, Gurunatha K. L., Mahesh Padaki and D. H. Nagaraju","doi":"10.1039/D5NA00311C","DOIUrl":"10.1039/D5NA00311C","url":null,"abstract":"Capacitive deionization (CDI) is an innovative technology that relies on the electrostatic adsorption of ions onto the electrode surface. Recently, the use of ion intercalation materials has been shown to be a viable method for increasing electrosorption capacity, which can greatly improve CDI performance. In this review, the most recent developments in ion intercalation, synthesis techniques, electrode performance, applications, and cell design in CDI systems are examined. Furthermore, this review highlights the economic feasibility, cost-effectiveness and development of technologies that use seawater sources to produce drinkable water compared with traditional desalination methods. Additionally, it draws attention to the function of advanced electrode materials in CDI, which highlights the possibilities of composite engineering for increased desalination efficiency. It also discusses the development of reliable and scalable CDI systems with improved capacities for environmentally friendly water filtration.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 14","pages":" 4270-4292"},"PeriodicalIF":4.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-assembled Ac-FFA-NH2 based hydrogels with strong immunostimulating activity for vaccine delivery† 自组装Ac-FFA-NH2基水凝胶，具有强免疫刺激活性，用于疫苗递送。

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-06-19 DOI: 10.1039/D5NA00033E

Nika Gazdek Serdar, Tihomir Pospišil, Marcela Šišić, Ivo Crnolatac, Petra Maleš, Ruža Frkanec and Leo Frkanec

{"title":"Self-assembled Ac-FFA-NH2 based hydrogels with strong immunostimulating activity for vaccine delivery†","authors":"Nika Gazdek Serdar, Tihomir Pospišil, Marcela Šišić, Ivo Crnolatac, Petra Maleš, Ruža Frkanec and Leo Frkanec","doi":"10.1039/D5NA00033E","DOIUrl":"10.1039/D5NA00033E","url":null,"abstract":"Recent research has demonstrated that peptide self-assemblies are effective as vaccine adjuvants, playing a critical role in enhancing vaccine efficacy. In our prior studies, the Ac-FFA-NH2 peptide gelator was identified as a biocompatible material suitable for tissue engineering applications. In this study, we reveal that the self-assembled Ac-FFA-NH2 hydrogel functions as a potent vaccine delivery system, as evidenced by its strong immunostimulatory activity in vivo. Mice vaccinated with OVA antigen incorporated into the hydrogel produced significantly higher IgG titers compared to both the unadjuvanted control group and those treated with traditional adjuvants. This suggests that the Ac-FFA-NH2 hydrogel effectively induces a robust humoral immune response. Moreover, the hydrogel not only enhances humoral immunity but also stimulates a cellular immune response, as indicated by the production of the IgG2a subtype, further establishing it as an excellent vaccine delivery platform. Additionally, we describe a composite hydrogel developed through the stepwise self-assembly of the Ac-FFA-NH2 peptide and liposomes. Structural characterization using TEM, DSC, and FTIR confirmed that both peptide nanofibers and lipid vesicles retain their structural integrity within the composite gel. Importantly, morphological analysis demonstrated that the mechanical robustness of the hydrogel remains largely unaffected by the presence of liposomes at lipid concentrations lower than the Ac-FFA-NH2 concentration.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 15","pages":" 4660-4672"},"PeriodicalIF":4.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A nanomagnetic triazole-based Schiff-base complex of palladium(0) as an efficient heterogeneous catalyst for the Mizoroki-Heck C-C cross-coupling reaction under green conditions. 纳米磁性三唑基希夫碱配合物钯(0)作为绿色条件下Mizoroki-Heck C-C交叉偶联反应的高效非均相催化剂。

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-06-18 DOI: 10.1039/d5na00364d

Yassin T H Mehdar, Fatimah Mohammed Alshamsan, Asma Ahmad Nashawi, Hussein Eledum, Ahmed Mohajja Alshammari, Jawza A Almutairi

{"title":"A nanomagnetic triazole-based Schiff-base complex of palladium(0) as an efficient heterogeneous catalyst for the Mizoroki-Heck C-C cross-coupling reaction under green conditions.","authors":"Yassin T H Mehdar, Fatimah Mohammed Alshamsan, Asma Ahmad Nashawi, Hussein Eledum, Ahmed Mohajja Alshammari, Jawza A Almutairi","doi":"10.1039/d5na00364d","DOIUrl":"10.1039/d5na00364d","url":null,"abstract":"A novel magnetically recoverable palladium(0) catalyst, [Fe3O4@triazole-Schiff-base-Pd(0)], was synthesized via a simple three-step functionalization. Magnetite nanoparticles were first modified with a haloalkane silane linker to introduce C-Cl functionalities, followed by nucleophilic substitution with a triazole-Schiff-base ligand derived from 3-amino-1,2,4-triazole and salicylaldehyde. Finally, coordination with palladium chloride and in situ reduction to Pd(0) afforded a stable, magnetically separable catalyst. Comprehensive characterization (FT-IR, XRD, TGA, EDX, ICP-OES, WDX, FE-SEM, TEM, and VSM) confirmed its successful synthesis. The catalyst demonstrated outstanding activity in the Mizoroki-Heck C-C cross-coupling reaction, resulting in efficient coupling of a diverse range of aryl iodides, bromides, and chlorides with butyl acrylate in PEG-400 as a green solvent and co-catalyst. It exhibited superior selectivity for aryl iodides and bromides and maintained high efficiency over eight consecutive cycles with minimal metal leaching. The use of cost-effective materials, facile magnetic recovery, and scalability make this catalyst an eco-friendly and economically viable alternative to conventional palladium-based methodologies.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Switching of supramolecular nanostructures at the solid-liquid interface: interplay of bias polarity and solution concentration. 固液界面超分子纳米结构的切换：偏置极性和溶液浓度的相互作用。

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-06-17 DOI: 10.1039/d5na00289c

Baoxin Jia, Mihaela Enache, Bettina D Gliemann, Angelina Jocic, Milan Kivala, Meike Stöhr

{"title":"Switching of supramolecular nanostructures at the solid-liquid interface: interplay of bias polarity and solution concentration.","authors":"Baoxin Jia, Mihaela Enache, Bettina D Gliemann, Angelina Jocic, Milan Kivala, Meike Stöhr","doi":"10.1039/d5na00289c","DOIUrl":"10.1039/d5na00289c","url":null,"abstract":"The self-assembly of a carboxy-functionalized triarylamine derivative (CTA) at the nonanoic acid-highly oriented pyrolytic graphite (NA-HOPG) interface is investigated using scanning tunnelling microscopy (STM). The study reveals that CTA molecules can self-assemble into diverse two-dimensional long-range ordered networks at the NA-HOPG interface, with their formation influenced by the concentration of the solution and the bias voltage of the STM tip. Moreover, reversible switching between the porous structures and the close-packed structure is induced by changing the bias polarity. We identify that for this phenomenon to occur the negatively polarised O atoms of the carboxylic groups of CTA play an important role, enabling the CTA molecules at the interface to desorb and re-adsorb which is essential for switching from one ordered arrangement to the other. Our findings demonstrate that reversible switching can be controlled by manipulating the solution concentration as well as the applied bias voltage, which holds promise for controlling switchable molecular systems at the solid-liquid interface.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12208213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generation of optical frequency combs in optically injected integrated gain-switched semiconductor lasers and their applications in Doppler LIDAR 光注入集成增益开关半导体激光器中光频梳的产生及其在多普勒激光雷达中的应用。

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-06-17 DOI: 10.1039/D5NA00260E

Yunshan Zhang, Yibing Chen, Mengxi Zhou, Yitong Liu, Wenxuan Ma, Zeyu Gang, Zhenxing Sun, Jilin Zheng, Xiangfei Chen and Pu Li

{"title":"Generation of optical frequency combs in optically injected integrated gain-switched semiconductor lasers and their applications in Doppler LIDAR","authors":"Yunshan Zhang, Yibing Chen, Mengxi Zhou, Yitong Liu, Wenxuan Ma, Zeyu Gang, Zhenxing Sun, Jilin Zheng, Xiangfei Chen and Pu Li","doi":"10.1039/D5NA00260E","DOIUrl":"10.1039/D5NA00260E","url":null,"abstract":"This paper introduces an optical frequency comb (OFC) source. It is constructed using a monolithically integrated gain-switched semiconductor laser with the optical injection technique. The theoretical analysis of the working principle of this integrated OFC source based on optical injection is carried out. Fabricated via micro–nano processing technology, the proposed OFC source has been experimentally investigated. The results clearly show that the optical injection method can notably increase the number of comb teeth with a higher carrier-to-noise ratio. The measured phase noise of the beat-frequency signal between comb teeth is less than −102 dBc Hz−1 @ 10 kHz. Moreover, a Doppler velocity-measuring LIDAR system is designed based on this OFC source, and the velocity of a moving target is measured. Compared with single-frequency speed measurement, using multi-comb teeth for speed measurement can significantly reduce the error.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 15","pages":" 4740-4748"},"PeriodicalIF":4.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new palladium complex Schiff-base on functionalized nanoboehmite as a reusable and practical catalyst for selective Suzuki C-C bond formation. 功能化纳米薄水铝石钯配合物席夫碱的可重复使用和实用的选择性铃木C-C键形成催化剂。

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-06-17 DOI: 10.1039/d5na00362h

Samaneh Heydarian, Bahman Tahmasbi, Mitra Darabi

引用次数: 0

Synthesis, redox exfoliation, and magnetic nanoparticle decoration of VSe₂ and SnSe₂ nanosheets. VSe2和SnSe2纳米片的合成、氧化还原剥离和磁性纳米粒子修饰。

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-06-16 DOI: 10.1039/d5na00536a

Zhengxi Xuan, Zheng Fu, B Medini Rajapakse, Ali Jawaid, Shuo Liu, Richard A Vaia, Luis Velarde, Paras N Prasad, Mark T Swihart

{"title":"Synthesis, redox exfoliation, and magnetic nanoparticle decoration of VSe2 and SnSe2 nanosheets.","authors":"Zhengxi Xuan, Zheng Fu, B Medini Rajapakse, Ali Jawaid, Shuo Liu, Richard A Vaia, Luis Velarde, Paras N Prasad, Mark T Swihart","doi":"10.1039/d5na00536a","DOIUrl":"10.1039/d5na00536a","url":null,"abstract":"Nanostructures exfoliated from layered van der Waals materials have attracted attention based upon their thickness-dependent optical and electronic properties. While magnetism has been observed in such 2D materials, available approaches to modulate or enhance their magnetic response remain limited. Thus, the magnetic response of 2D materials is of particular interest. Relatively few reports focus on colloidal routes to synthesize layered materials from which 2D nanostructures can be obtained by exfoliation. Herein, we present a general method to synthesize bulk vanadium diselenide (VSe2) and dual-phase tin diselenide SnSe2-SnSe followed by liquid phase redox exfoliation to delaminate these materials into 2D nanostructures of different thicknesses. The delamination process induces phase changes, affecting the overall magnetic and optical behavior. The magnetization of these 2D nanostructures of different thicknesses increases with an increasing exfoliation degree (decreasing size and thickness). Moreover, we decorated these 2D nanostructures with colloidally synthesized iron oxide dots (Fe x O y , ∼4 nm diameter). This enhanced the magnetic response, which reached a saturation magnetization of 32 emu g-1 for VSe2-Fe x O y and 2.7 emu g-1 for SnSe2-Fe x O y . A synergistic effect is observed, in which the magnetization of the Fe x O y decorated VSe2 significantly exceeds that of either Fe x O y itself or VSe2 alone. This report provides a general method to synthesize 2D nanostructures of varied thickness and to decorate them with magnetic nanoparticles to achieve synergistic magnetic response.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diesel exhaust particles modulate bone remodeling and worsen osteoporosis: in vitro and in vivo investigations† 柴油废气颗粒调节骨重塑和加重骨质疏松症：在体外和体内的调查。

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-06-16 DOI: 10.1039/D5NA00254K

Vaishnavi N, Saravanan Sekaran, Renugaa Suresh babu, Swathi Sudhakar and Selvaraj Vimalraj

{"title":"Diesel exhaust particles modulate bone remodeling and worsen osteoporosis: in vitro and in vivo investigations†","authors":"Vaishnavi N, Saravanan Sekaran, Renugaa Suresh babu, Swathi Sudhakar and Selvaraj Vimalraj","doi":"10.1039/D5NA00254K","DOIUrl":"10.1039/D5NA00254K","url":null,"abstract":"Air pollution poses significant risks to public health, with diesel exhaust particles (DEP) contributing to a variety of systemic effects, including potential impacts on bone metabolism. This study investigates DEP's osteogenic and bone toxic effects using both in vitro pre-osteoblast models and in vivo Zebrafish models under healthy and osteoporotic conditions. Pre-osteoblasts treated with DEP exhibited enhanced calcium deposition and upregulated osteogenic markers, including Runx2 and type I collagen, at 25–50 μg ml−1 concentrations. Zebrafish larvae and adult models demonstrated similar concentration-dependent responses, with increased mineralization observed at lower DEP doses and reduced mineralization at higher concentrations (≥100 μg ml−1). Notably, DEP exposure in osteoporotic Zebrafish consistently impaired bone regeneration and fracture healing, as evidenced by diminished calcium deposition, reduced alkaline phosphatase activity, and increased osteoclast activity. Mechanistically, DEP was shown to act through the aryl hydrocarbon receptor (AhR) pathway, disrupting the balance between osteoblast and osteoclast activity. At higher doses or under pathological conditions such as osteoporosis, DEP significantly impairs bone regeneration, delays fracture healing, and promotes bone resorption. The distinct responses elicited by these particles in healthy compared to osteoporotic bone highlight their dualistic nature and underscore the need for condition-specific investigation. This research underscores the importance of the risks associated with chronic DEP exposure in vulnerable populations. Future studies should focus on elucidating the molecular mechanisms underlying DEP's biphasic effects and exploring mitigation strategies for its adverse impacts on bone health.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 15","pages":" 4577-4590"},"PeriodicalIF":4.6,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12168921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0