Nanoscale Advances最新文献

{"title":"A novel fullerene-lysine derivative with noticeable ROS scavenging capabilities for improving type 2 diabetes mellitus","authors":"Jiaqi Weng, Wei Guo, Jie Liu, Kollie Larwubah, Jianjun Guo, Yanrong Jia and Meilan Yu","doi":"10.1039/D4NA01081G","DOIUrl":"10.1039/D4NA01081G","url":null,"abstract":"<p >As some of the most promising candidates available, fullerene-derived bioactive agents have been explored as new drugs with high efficacy and safety for biomedical applications. In this study, a fullerene-lysine derivative (C<small>₆₀</small>-Lys) was synthesized successfully and proved to be good at treating type 2 diabetes mellitus (T2DM). C<small>₆₀</small>-Lys could alleviate oxidative stress both in streptozotocin (STZ)-induced MIN6 cells and in STZ-induced T2DM mice subjected to a high-fat diet, and it significantly normalized glucose uptake and reduced blood glucose. In addition, C<small>₆₀</small>-Lys can alleviate insulin resistance, hyperinsulinemia and lipid levels in T2DM mice. It was further confirmed that C<small>₆₀</small>-Lys could alleviate oxidative stress by increasing the activities of antioxidant enzymes and stabilizing the mitochondrial membrane potential (MMP) of pancreatic β-cells to reduce the overproduction of ROS. The results provide compelling evidence that C<small>₆₀</small>-Lys possesses promising applications for T2DM treatment.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 11","pages":" 3462-3475"},"PeriodicalIF":4.6,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of emerging trends in nanomaterial-driven AI for biomedical applications.","authors":"Subhendu Chakroborty, Nibedita Nath, Sameeta Sahoo, Bhanu Pratap Singh, Trishna Bal, Karunesh Tiwari, Yosief Kasshun Hailu, Sunita Singh, Pravin Kumar, Chandra Chakraborty","doi":"10.1039/d5na00032g","DOIUrl":"https://doi.org/10.1039/d5na00032g","url":null,"abstract":"<p><p>The field of artificial intelligence (AI) is expanding quickly. To mimic the structure and biological evolution of the human brain, AI was developed to enable computers to acquire knowledge and manipulate their surroundings. There have been notable developments in the use of AI in healthcare; it can enhance diagnosis and treatment in various medical specialties. The cost of prompt diagnosis and treatment is hampered by the absence of efficient, dependable, and reasonably priced detection and real-time monitoring. Smart health tracking systems integrating AI and nanoscience are an emerging frontier that solves these obstacles. Targeted delivery of drug systems, biosensing, imaging, and other diagnostic and therapeutic fields can widely benefit abundantly from nanoscience in healthcare. AI technology has the potential to expand biomedical applications by analyzing and interpreting biological data, speeding up drug discovery, and identifying novel molecules with predictive behavior. This review outlines the current obstacles and potential opportunities for delivering personal healthcare using AI-assisted clinical decision support systems.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12071765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing the cavity architecture in double gate junctionless field effect transistors for enhanced biomolecule detection.","authors":"Shahriar Khan, Ehsanur Rahman","doi":"10.1039/d4na00928b","DOIUrl":"https://doi.org/10.1039/d4na00928b","url":null,"abstract":"<p><p>This study has investigated double-gate junctionless field effect transistor (DG-JLFET) designs with different cavity configurations and assessed their impact on biosensing performance. Through simulations and analysis of the electrical properties, this study has identified structures that significantly enhance biosensing performance compared to traditional DG-JLFETs. Different cavity architectures have been simulated and evaluated using key biosensing metrics, including the threshold voltage, change in threshold voltage, percentage change in threshold voltage, change in the minimum point of surface potential, <i>I</i> _on-off ratio, and sensitivity. Analysis of all the structures has revealed that no single structure has outperformed others across all the metrics when the dielectric constant is varied over a wide range. Notably, structure D, featuring drain side cavities, has shown the highest <i>I</i> _on-off ratio, with values of 3.03 × 10⁷-3.73 × 10⁷ for keratin. In contrast, structure E, with an asymmetrical cavity arrangement featuring an upper cavity on the left and a lower cavity on the right, has exhibited the highest sensitivity, achieving 98.63%-99.25% for the same biomolecule. When considering sensitivity as the key biosensing metric, structures E, F (alternating cavities on the vertical axis), and G (a central upper cavity and bilateral lower cavities) have shown better performance than all the other configurations. This study has further investigated the effect of varying the dielectric constant and channel occupancy of biomolecules on biosensing performance. For the above parametric variations, structure E has shown the highest change in the threshold voltage, while structure G has achieved the highest percentage change in the threshold voltage. These results contribute to the systematic design of DG-JLFET-based biosensors, providing a framework for optimizing cavity architectures to enhance biomolecule detection sensitivity.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent progress in the synthesis of nanostructured Ti₃C₂T _<i>x</i> MXene for energy storage and wastewater treatment: a review.","authors":"Qui Thanh Hoai Ta, Jianbin Mao, Ngo Thi Chau, Ngoc Hoi Nguyen, Dieu Linh Tran, Thi My Huyen Nguyen, Manh Hoang Tran, Hoang Van Quy, Soonmin Seo, Dai Hai Nguyen","doi":"10.1039/d5na00021a","DOIUrl":"https://doi.org/10.1039/d5na00021a","url":null,"abstract":"<p><p>MXene-based functional 2D materials hold significant potential for addressing global challenges related to energy and water crises. Since their discovery in 2011, Ti₃C₂T _<i>x</i> MXenes have demonstrated promising applications due to their unique physicochemical properties and distinctive morphology. Recent advancements have explored innovative strategies to enhance Ti₃C₂T _<i>x</i> into multifunctional materials, enabling applications in gas sensing, electromagnetic interference shielding, supercapacitors, batteries, water purification, and membrane technologies. Unlike previous reviews that primarily focused on the synthesis, properties, and individual applications of MXenes, this work provides a fundamental discussion of their role in wastewater treatment, recent advancements in energy harvesting, and their broader implications. Additionally, this review offers a comparative analysis of MXene-based systems with other state-of-the-art materials, providing new insights into their future development and potential applications.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and in vitro and ex vivo characterization of a twin nanoparticulate system to enhance ocular absorption and prolong retention of dexamethasone in the eye: from lab to pilot scale optimization†","authors":"Muhammad Sarfraz, Goutam Behl, Sweta Rani, Niall O'Reilly, Peter McLoughlin, Orla O'Donovan, Alison L. Reynolds, John Lynch and Laurence Fitzhenry","doi":"10.1039/D4NA01086H","DOIUrl":"https://doi.org/10.1039/D4NA01086H","url":null,"abstract":"<p >Conventional eye drops show low bioavailability (below 20%) due to the eye's inherent tissue barriers and unique microenvironment. Recent advancements in pharmaceutical nanotechnology have explored various nanoparticle systems, such as micelles, liposomes, and nanoemulsions, to enhance corneal permeation and prolong drug retention. In this study, we propose a twin nanoparticulate system, combining the advantages of two nanoparticles to improve drug targeting and therapeutic efficacy. A dexamethasone-loaded liposome–microemulsion (LME) twin nanoparticulate system was developed using high-pressure homogenization and successfully scaled up. Both liposomes and microemulsions were of similar size (∼60 nm) and displayed uniform distribution (polydispersity index &lt; 0.2) upon combination. The final formulation was hypo-osmolar (osmolality &lt; 100 mOsm per Kg), making it ideal for dry eye relief. Drug release was extended for up to 8 h, following a non-Fickian diffusion pattern. The LME formulation, tested under different conditions (2–8 °C and 25 °C with 60% relative humidity), was found to be stable for 6 months. It showed no cytotoxicity in human corneal epithelial cells up to 10 μM drug concentration. Fluorescence microscopy revealed rapid nanoparticle uptake by cells within 5 minutes. Human corneal epithelial cells showed a marked reduction in inflammatory biomarkers (IL-6, IL-8, and TNF-α) after drug-loaded LME treatments, compared to the control. Corneal tissue imaging confirmed prolonged retention of nanoparticles within the tissue. A whole eye <em>ex vivo</em> permeation study demonstrated higher drug concentrations in the aqueous humour of LME drug-treated rabbit eyes compared to a reference product. This twin nanoparticulate system, loaded with dexamethasone, offers a promising next-generation treatment for dry eye disease (DED).</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 10","pages":" 3125-3142"},"PeriodicalIF":4.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/na/d4na01086h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical role of precursor flux in modulating nucleation density in 2D material synthesis revealed by a digital twin†","authors":"Abhinav Sinha, Manvi Verma, Nandeesh Kumar K. M., Keerthana S. Kumar, Ananth Govind Rajan and Akshay Singh","doi":"10.1039/D5NA00202H","DOIUrl":"10.1039/D5NA00202H","url":null,"abstract":"<p >Chemical vapor deposition (CVD) is the most widespread approach for two-dimensional (2D) material synthesis, yet control of nucleation density remains a major hurdle towards large-area growth. We find that precursor flux, a function of gas velocity and precursor concentration, is the critical parameter controlling nucleation. We observe that for a vertically aligned substrate, the presence of a cavity/slot in the substrate-supporting plate creates an enhanced growth zone for 2D-MoS<small>₂</small>. The effect of this confined space on nucleation density is experimentally verified by electron microscopy. To understand this intriguing observation, we developed a hyper-realistic multiphysics computational fluid dynamics model, <em>i.e.</em>, a digital twin of our CVD reactor, which reveals that space confinement achieves nearly-zero gas velocities. Digital twin-informed calculations indicate a significantly lower metal precursor flux at the confined space during the initial stages of growth, while precursor concentration is uniform across the substrate. The digital twin also makes an important prediction regarding a large time-lag between the set temperature, reactor environmental temperature, and substrate temperature, with implications for nucleation and growth. We offer a framework for designing confined spaces to control nucleation <em>via</em> regulating precursor flux, and for simulating reactor parameters for rapid optimization <em>via</em> the digital-twin model.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 11","pages":" 3568-3578"},"PeriodicalIF":4.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in molecular imaging for the diagnosis and treatment of pancreatic ductal adenocarcinoma","authors":"Xun Hu, Zihua Wang, Yuting Zhu, Zhangfu Li, Hao Yan, Xinming Zhao and Qian Wang","doi":"10.1039/D4NA01080A","DOIUrl":"https://doi.org/10.1039/D4NA01080A","url":null,"abstract":"<p >Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant tumor characterized by poor overall patient survival and prognosis, largely due to challenges in early diagnosis, limited surgical options, and a high propensity for therapy resistance. The integration of various imaging modalities through molecular imaging techniques, particularly multimodal molecular imaging, offers the potential to provide more precise and comprehensive information about the lesion. With advances in nanomedicine, new imaging and drug delivery approaches that allow the development of multifunctional theranostic agents offer opportunities for improving pancreatic cancer treatment using precision oncology. Herein, we review the diagnostic and therapeutic applications of molecular imaging for PDAC and discuss the adoption of multimodal imaging approaches that combine the strengths of different imaging techniques to enhance diagnostic accuracy and therapeutic efficacy. We emphasize the significant role of nanomedicine technology in advancing multimodal molecular imaging and theranostics, and their potential impact on PDAC management. This comprehensive review aims to serve as a valuable reference for researchers and clinicians, offering insights into the current state of molecular imaging in PDAC and outlining future directions for improving early diagnosis, combination therapies, and prognostic evaluations.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 10","pages":" 2887-2903"},"PeriodicalIF":4.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/na/d4na01080a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143944099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic hyperthermia-triggered multi-functional thermo-responsive lipid nanoparticles for enhanced paclitaxel release and cytotoxicity.","authors":"Muhammad Tayyab, Naveed Ahmed, Muhammad Hisham Al Nasir, Ayesha Ihsan, Asim Ur Rehman, Khurram Shahzad Munawar, Daniel Jaque Garcia, Maria Del Carmen Iglesias de la Cruz, Mubashar Rehman","doi":"10.1039/d5na00072f","DOIUrl":"10.1039/d5na00072f","url":null,"abstract":"<p><p>The inadequate safety and efficacy of chemotherapy have led cancer medicine to focus on localizing drug delivery to the target. Thermoresponsive nanocarriers (liposomes and polymeric networks) exploit local hyperthermia to trigger targeted payload release; however, their low stability and unpredictable fate <i>in vivo</i> have led to failure in clinical studies. To overcome these challenges, we reported first-of-its-kind thermoresponsive lipid nanoparticles (TLNs) that undergo solid-liquid phase transition under hyperthermia to release the payload. This study enabled TLNs with on-demand drug delivery functionality to breast cancer cells by incorporating magnetically activated iron oxide nanoparticles (γ-Fe₂O₃) into a lauric and oleic acid-based phase-changing lipid-matrix to synthesize paclitaxel (PTX)- and γ-Fe₂O₃-loaded TLNs (P-γ-TLN). Critical independent variables were selected and then optimized using a central composite design to obtain the optimized formulation, P-γ-TLN 12, with a size of ∼183 nm, polydispersity of 0.50, zeta potential of -22 mV, and encapsulation efficiencies of 85% for PTX and 60.49% for γ-Fe₂O₃. Thermoresponsive delivery was confirmed, with TLNs remaining relatively stable at 37 °C for 72 h, releasing only 34.26% of the drug, whereas exposure to 45 °C resulted in more than a two-fold increase, releasing 79.35% over the same period. Under an external alternating magnetic field, γ-Fe₂O₃ generated hyperthermia and induced a phase transition in P-γ-TLN, leading to abrupt drug release. Both γ-Fe₂O₃ and TLNs exhibited high biocompatibility, but TLN encapsulation significantly improved uptake in MCF-7 breast cancer cells. Under AMF, P-γ-TLN showed enhanced PTX release, resulting in more potent cytotoxicity against MCF-7 cells. The combination of high payload capacity, stimuli-responsive release, thermotherapy, and enhanced chemotherapeutic response highlights the substantial potential for TLNs in cancer therapy.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An organometallic approach to sub-2 nm thiolate-protected Au nanoclusters with enhanced catalytic and therapeutic properties†","authors":"Irene del-Campo, Alba Sorroche, Nina Allen, Mattia Ghirardello, Francisco Corzana, M. Carmen Galán, Miguel Monge and José M. López-de-Luzuriaga","doi":"10.1039/D5NA00123D","DOIUrl":"10.1039/D5NA00123D","url":null,"abstract":"<p >Thiolate-protected gold nanoclusters (AuNCs) of sub-2 nm size have been synthesized through a novel bottom-up approach using the organometallic precursor [Au(C<small>₆</small>F<small>₅</small>)(tht)] (tht = tetrahydrothiophene) in a one-pot reaction under mild conditions. This protocol is simple, rapid (1 h), versatile (applicable to thiolate ligands of varying molecular sizes), and reproducible, yielding AuNCs with low size dispersion. Furthermore, the resulting nanomaterials exhibited remarkable catalytic activity, effectively reducing the pollutant 4-nitrophenol to 4-aminophenol, as well as promising photothermal and photodynamic properties upon exposure to an 808 nm laser, converting light into thermal energy and generating reactive oxygen species (ROS). Additionally, AuNCs stabilized with a nonapeptide demonstrated efficient catalase-like activity, thereby potentially enhancing the efficacy of photodynamic therapy. The cytotoxic effects against cancer (HeLa) and healthy cells (HDF) were also evaluated, showing greater selectivity for HeLa cells, with higher toxicity and increased ROS generation.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 11","pages":" 3228-3235"},"PeriodicalIF":4.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12053774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cycloaddition reaction of NaN₃ with nitriles toward the synthesis of tetrazoles catalyzed by a copper complex on boehmite nanoparticles.","authors":"Arida Jabbari, Bahman Tahmasbi, Elham Mohseni, Mitra Darabi","doi":"10.1039/d5na00081e","DOIUrl":"https://doi.org/10.1039/d5na00081e","url":null,"abstract":"<p><p>In the present study, the synthesis of boehmite nanoparticles was done using a hydrothermal method using an aluminum source in water solvent. The synthesized boehmite support was modified using (3-iodopropyl)trimethoxysilane (3-IPTMS), and then the modified boehmite was functionalized using a Schiff-base ligand. Finally, copper ions were immobilized on the functionalized boehmite denoted as a boehmite@Schiff-base-Cu nanocatalyst. The synthesized catalyst was identified and confirmed using SEM, FT-IR, TGA, EDXS, WDX, XRD, and BET techniques. The activity of boehmite@Schiff-base-Cu was investigated in preparing 5-substituted tetrazoles using nitrile derivatives and sodium azide, in which short reaction times and high yields were observed in described reactions. Also, the many advantages of the boehmite@Schiff-base-Cu nanocatalyst are ease of operation, compatibility with the environment, its easy separation from the reaction medium, and the ability to reuse it several times without significantly reducing its catalytic activity.</p>","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}