Nanoscale Advances最新文献_第5页

The role of energy deposition on the luminescence sensitization in porphyrin-functionalized SiO₂/ZnO nanoparticles under X-ray excitation.

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-01-08 DOI: 10.1039/d4na00640b

Irene Villa, Roberta Crapanzano, Silvia Mostoni, Anne-Laure Bulin, Massimiliano D'Arienzo, Barbara Di Credico, Anna Vedda, Roberto Scotti, Mauro Fasoli

{"title":"The role of energy deposition on the luminescence sensitization in porphyrin-functionalized SiO2/ZnO nanoparticles under X-ray excitation.","authors":"Irene Villa, Roberta Crapanzano, Silvia Mostoni, Anne-Laure Bulin, Massimiliano D'Arienzo, Barbara Di Credico, Anna Vedda, Roberto Scotti, Mauro Fasoli","doi":"10.1039/d4na00640b","DOIUrl":"10.1039/d4na00640b","url":null,"abstract":"Hybrid nanoscintillators, which feature a heavy inorganic nanoparticle conjugated with an organic emitter, represent a promising avenue for advancements in diverse fields, including high-energy physics, homeland security, and biomedicine. Many research studies have shown the suitability of hybrid nanoscintillators for radiation oncology, showing potential to improve therapeutic results compared to traditional protocols. In this work, we studied SiO2/ZnO nanoparticles functionalized with porphyrin as a photosensitizer, capable of producing cancer cytotoxic reactive oxygen species for possible use in radio-oncological therapeutics. Radioluminescence measurements under increasing energy of the ionizing radiation beam up to 10 keV show sensitization of porphyrin moieties on SiO2/ZnO. This can be attributed to an increase in energy deposition promoted by the ZnO nanoparticles, which have a higher density and atomic number. This assumption was confirmed by computational simulations of energy deposition after the first interaction of ionizing radiation with SiO2, ZnO, and air. Indeed, Monte Carlo simulations evidence that, despite a decrease in the absolute number of X-rays interacting within the system while increasing the energy of the beam, at 10 keV, the presence of ZnO is dominant to enhance energy deposition. Hence, these experimental and computational studies evidence the importance of each hybrid nanosystem component in the scintillation process. This work shows how an appropriate choice of constituents, in terms of physicochemical properties and architecture, can favour energy deposition mechanisms under X-ray irradiation and thus can boost the hybrid nanosystems' performance for diverse biomedical scintillation-based applications.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A customizable wireless potentiostat for assessing Ni(OH)₂ decorated vertically aligned MoS₂ thin films for electrochemical sensing of dopamine.

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-01-08 DOI: 10.1039/d4na00914b

Topias Järvinen, Olli Pitkänen, Tomi Laurila, Minna Mannerkorpi, Simo Saarakkala, Krisztian Kordas

引用次数: 0

Hydrothermal carbonization synthesis of amorphous carbon nanoparticles (15-150 nm) with fine-tuning of the size, bulk order, and the consequent impact on antioxidant and photothermal properties.

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-01-08 DOI: 10.1039/d4na00923a

Francesco Barbero, Elena Destro, Aurora Bellone, Ludovica Di Lorenzo, Valentina Brunella, Guido Perrone, Alessandro Damin, Ivana Fenoglio

{"title":"Hydrothermal carbonization synthesis of amorphous carbon nanoparticles (15-150 nm) with fine-tuning of the size, bulk order, and the consequent impact on antioxidant and photothermal properties.","authors":"Francesco Barbero, Elena Destro, Aurora Bellone, Ludovica Di Lorenzo, Valentina Brunella, Guido Perrone, Alessandro Damin, Ivana Fenoglio","doi":"10.1039/d4na00923a","DOIUrl":"10.1039/d4na00923a","url":null,"abstract":"Hydrothermal carbonization (HTC) of carbohydrates has been reported as a sustainable and green technique to produce carbonaceous micro- and nano-materials. These materials have been developed for several applications, including catalysis, separation science, metal ion adsorption and nanomedicine. Carbon nanoparticles (CNPs) obtained through HTC are particularly interesting for the latter application since they exhibit photothermal properties when irradiated with near-infrared (NIR) light, act as an antioxidant by scavenging reactive oxygen species (ROS), and present good colloidal stability and biocompatibility. However, due to the highly disordered structure, there is still a poor understanding of the mechanism of synthesis of CNPs. Consequently, the modulation of the CNP properties by controlling the synthetic parameters is still a challenge. In this work, a novel and simplified HTC synthetic strategy to obtain non-aggregated glucose derived CNPs in the 15-150 nm size range with precise control of the diameter is presented, together with an advance in the understanding of the reaction mechanism behind the synthesis. Modifications of the synthetic parameters and a post-synthesis hydrothermal process were applied to increase the bulk order of CNPs, resulting in an increase of the photothermal and ROS scavenging activities, without affecting the morphological and colloidal properties of the nanomaterial.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-particle tracking of polymer aggregates inside disordered porous media† 无序多孔介质中聚合物聚集体的单粒子跟踪。

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-01-08 DOI: 10.1039/D4NA00873A

Yusaku Abe, Naoki Tomioka and Yu Matsuda

引用次数: 0

Pre-validation of a novel reconstructed skin equivalent model for skin irritation and nanoparticle risk assessment. 一种用于皮肤刺激和纳米颗粒风险评估的新型重建皮肤等效模型的预验证。

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-01-08 DOI: 10.1039/d4na00804a

Priscila Laviola Sanches, Rosana Bizon Vieira Carias, Gutember Gomes Alves, Carolina Motter Catarino, Bruna Bosquetti, Meg Cristina De Castilho Costa, Andrezza Di Pietro Micali, Desirée Cigaran Schuck, José Mauro Granjeiro, Ana R Ribeiro

{"title":"Pre-validation of a novel reconstructed skin equivalent model for skin irritation and nanoparticle risk assessment.","authors":"Priscila Laviola Sanches, Rosana Bizon Vieira Carias, Gutember Gomes Alves, Carolina Motter Catarino, Bruna Bosquetti, Meg Cristina De Castilho Costa, Andrezza Di Pietro Micali, Desirée Cigaran Schuck, José Mauro Granjeiro, Ana R Ribeiro","doi":"10.1039/d4na00804a","DOIUrl":"10.1039/d4na00804a","url":null,"abstract":"In alignment with the global movement toward reducing animal testing, several reconstructed human epidermis (RHE) models have been created for conducting skin irritation tests. These models have undergone development, verification, validation, and integration into OECD TG 439. Our team has introduced a novel in-house RHE named GB-RHE, and we adhere to OECD TG 439 to pre-validate the model and test its potential employment for nanoparticle irritation studies. GB-RHE exhibits morphological, biochemical, and physiological attributes equivalent to the human epidermis, featuring well-differentiated multilayered viable keratinocytes with a robust barrier function. The performance of the GB-RHE model was evaluated using ten reference chemicals, following the performance standard of OECD TG 439. The results demonstrated commendable predictive capacity and showed that titanium dioxide nanoparticles (TiO2 NPs) are 'non-irritant' to the human epidermis following the globally harmonized classification system. However, although the histological analysis did not show morphological changes, transmission electron micrographs demonstrated that TiO2 NPs can be internalized, reaching the external viable layers of the epidermis. This study demonstrates that in addition to the potential of the GB-RHE model to evaluate skin irritation, this model also has the potential to evaluate the skin toxicity of NPs and carry out cell internalization studies.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly selective ethanol gas sensor based on CdS/Ti₃C₂T _x MXene composites.

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-01-08 DOI: 10.1039/d4na00927d

Ly Tan Nhiem, Jianbin Mao, Qui Thanh Hoai Ta, Soonmin Seo

{"title":"Highly selective ethanol gas sensor based on CdS/Ti3C2T x MXene composites.","authors":"Ly Tan Nhiem, Jianbin Mao, Qui Thanh Hoai Ta, Soonmin Seo","doi":"10.1039/d4na00927d","DOIUrl":"10.1039/d4na00927d","url":null,"abstract":"Sensing of hazardous gases has an important role in ensuring safety in a variety of industries as well as environments. Mainly produced by the combustion of fossil fuels and other organic matter, ethanol is a dangerous gas that endangers human health and the environment. Stability and sensing sensitivity are major considerations when designing gas sensors. Here, a superior ethanol sensor with a high response and fast recovery was synthesized by \"wrapping\" CdS nanoparticles on metallic Ti3C2T x MXene using a simple method. CdS nanoparticles were uniformly covered on the Ti3C2T x MXene surface, forming a \"rice crust\"-like heterostructure. The sensor displayed good detection of ethanol gas at room temperature. Response signals up to 31% were obtained for ethanol molecules (20 ppm) with quick recovery (41 s). The performance of the ethanol sensor was evaluated across a range of concentrations (5-100 ppm) and relative humidity (60% and 90% RH) at room temperature. Our method could open up a new strategy for the development of ethanol sensors.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Excitonic circular dichroism in boron-nitrogen cluster decorated graphene.

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2025-01-06 DOI: 10.1039/d4na00759j

Shneha Biswas, Souren Adhikary, Sudipta Dutta

引用次数: 0

High-porosity Pt-CeO₂ nanosponges as oxidation catalyst. 高孔隙率Pt-CeO2纳米海绵作为氧化催化剂。

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2024-12-30 DOI: 10.1039/d4na00525b

Simon Falkner, Carina B Maliakkal, Mareike Liebertseder, Joachim Czechowsky, Maria Casapu, Jan-Dierk Grunwaldt, Christian Kübel, Claus Feldmann

{"title":"High-porosity Pt-CeO2 nanosponges as oxidation catalyst.","authors":"Simon Falkner, Carina B Maliakkal, Mareike Liebertseder, Joachim Czechowsky, Maria Casapu, Jan-Dierk Grunwaldt, Christian Kübel, Claus Feldmann","doi":"10.1039/d4na00525b","DOIUrl":"https://doi.org/10.1039/d4na00525b","url":null,"abstract":"Pt-CeO2 nanosponges (1 wt% Pt) with high surface area (113 m2 g-1), high pore volume (0.08 cm3 g-1) and small-sized Pt nanoparticles (1.8 ± 0.4 nm) are prepared by thermal decomposition of a cerium oxalate precursor and examined for catalytic oxidation of CO, volatile organic compounds (VOCs), and NH3. The cerium oxalate precursor Ce2(C2O4)3·10H2O is prepared by aqueous precipitation from Ce(NO3)3·6H2O and K2C2O4·H2O and thermally converted to CeO2 nanosponges by heating in air. Optimal conditions for decomposition in terms of surface area and porosity are observed at 350 °C for 20 min. Finally, the CeO2 nanosponges are decorated with small-sized Pt nanoparticles, using a wet-chemical impregnation with Pt(ac)2 in methanol. Electron microscopy with tomography, electron spectroscopy and further methods (TG, XRD, FT-IR, sorption analysis) are used to characterize the catalyst composition and especially the structure and porosity of the Pt-CeO2 nanosponges as well as the uniform distribution of the Pt nanoparticles. The Pt-CeO2 nanosponges show good thermal stability (up to 400 °C) and, already as a new, non-optimized catalyst, promising activity for catalytic oxidation of CO, VOCs, NH3 as indicated by high activities in terms of low and stable light-out and light-off temperatures as well as a high selectivity to N2 (for NH3 oxidation) with >80% at 170-250 °C.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photocatalytic CO₂ reduction of Ag/Ag₂S/Ti₃C₂T _X heterojunctions with enhanced interfacial charge transfer. 增强界面电荷转移的Ag/Ag2S/ ti3c2tx异质结光催化CO2还原

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2024-12-30 DOI: 10.1039/d4na00969j

Bo Zhang, Yijun Chen, Fei Li, Yang Zhang, Xiang Li, Wuwan Xiong, Weili Dai

{"title":"Photocatalytic CO2 reduction of Ag/Ag2S/Ti3C2T X heterojunctions with enhanced interfacial charge transfer.","authors":"Bo Zhang, Yijun Chen, Fei Li, Yang Zhang, Xiang Li, Wuwan Xiong, Weili Dai","doi":"10.1039/d4na00969j","DOIUrl":"10.1039/d4na00969j","url":null,"abstract":"Photocatalytic reduction of CO2 to produce organic fuels is a promising strategy for addressing carbon reduction and energy scarcity. Transition metal carbides (Ti3C2T X ) are of particular interest due to their unique layered structures and excellent electrical conductivity. However, the practical application of Ti3C2T X is limited by the poor separation efficiency of photogenerated charge carriers and the low migration ability of photogenerated electrons. Herein, Ag/Ag2S/Ti3C2T X heterojunctions were synthesized by depositing Ag/Ag2S nanoparticles onto layered Ti3C2T X substrates using a combination of co-precipitation and photoreduction methods. Fluorescence spectra, UV diffuse reflection, and photoelectric chemical characterizations demonstrated that Ag/Ag2S/Ti3C2T X heterojunctions provided effective channels for the reverse and synergistic migration of electrons and holes, leading to improved spatial separation. Notably, the Ag component in the composite acts as an electron acceptor and reactive center, significantly enhancing the migration ability of photogenerated electrons. The total alcohol yield over Ag/Ag2S/Ti3C2T X (125.3 μmol gcatal. -1) was 5.1 times higher than that on Ag2S (24.7 μmol gcatal. -1) and 2.1 times higher than on Ti3C2T X (60.7 μmol gcatal. -1). This study offers valuable insights into designing efficient photocatalytic CO2 reduction catalysts.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11708830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142951832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone-derived nanoparticles (BNPs) enhance osteogenic differentiation via Notch signaling† 骨源性纳米颗粒（BNPs）通过Notch信号传导增强成骨分化。

IF 4.6 3区材料科学

Nanoscale Advances Pub Date : 2024-12-27 DOI: 10.1039/D4NA00797B

Austin Stellpflug, Justin Caron, Samantha Fasciano, Bo Wang and Shue Wang

{"title":"Bone-derived nanoparticles (BNPs) enhance osteogenic differentiation via Notch signaling†","authors":"Austin Stellpflug, Justin Caron, Samantha Fasciano, Bo Wang and Shue Wang","doi":"10.1039/D4NA00797B","DOIUrl":"10.1039/D4NA00797B","url":null,"abstract":"Mesenchymal stem cell (MSC)-based bone tissue regeneration has gained significant attention due to the excellent differentiation capacity and immunomodulatory activity of MSCs. Enhancing osteogenesis regulation is crucial for improving the therapeutic efficacy of MSC-based regeneration. By utilizing the regenerative capacity of bone ECM and the functionality of nanoparticles, we recently engineered bone-based nanoparticles (BNPs) from decellularized porcine bones. The effects of internalization of BNPs on MSC viability, proliferation, and osteogenic differentiation were first investigated and compared at different time points. The phenotypic behaviors, including cell number, proliferation, and differentiation were characterized and compared. By incorporating a LNA/DNA nanobiosensor and MSC live cell imaging, we monitored and compared Notch ligand delta-like 4 (Dll4) expression dynamics in the cytoplasm and nucleus during osteogenic differentiation. Pharmacological interventions are used to inhibit Notch signaling to examine the mechanisms involved. The results suggest that Notch inhibition mediates the osteogenic process, with reduced expression of early and late stage differentiation markers (ALP and calcium mineralization). The internalization of BNPs led to an increase in Dll4 expression, exhibiting a time-dependent pattern that aligned with enhanced cell proliferation and differentiation. Our findings indicate that the observed changes in BNP-treated cells during osteogenic differentiation could be associated with elevated levels of Dll4 mRNA expression. In summary, this study provides new insights into MSC osteogenic differentiation and the molecular mechanisms through which BNPs stimulate this process. The results indicate that BNPs influence osteogenesis by modulating Notch ligand Dll4 expression, demonstrating a potential link between Notch signaling and the proteins present in BNPs.","PeriodicalId":18806,"journal":{"name":"Nanoscale Advances","volume":" 3","pages":" 735-747"},"PeriodicalIF":4.6,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0