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A roadmap for clinical trials in MASH-related compensated cirrhosis MASH 相关代偿性肝硬化临床试验路线图
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-17 DOI: 10.1038/s41575-024-00955-8
Juan M. Pericàs, Quentin M. Anstee, Salvador Augustin, Ramón Bataller, Annalisa Berzigotti, Andreea Ciudin, Sven Francque, Juan G. Abraldes, Virginia Hernández-Gea, Mònica Pons, Thomas Reiberger, Ian A. Rowe, Peter Rydqvist, Elmer Schabel, Frank Tacke, Emmanuel A. Tsochatzis, Joan Genescà
{"title":"A roadmap for clinical trials in MASH-related compensated cirrhosis","authors":"Juan M. Pericàs, Quentin M. Anstee, Salvador Augustin, Ramón Bataller, Annalisa Berzigotti, Andreea Ciudin, Sven Francque, Juan G. Abraldes, Virginia Hernández-Gea, Mònica Pons, Thomas Reiberger, Ian A. Rowe, Peter Rydqvist, Elmer Schabel, Frank Tacke, Emmanuel A. Tsochatzis, Joan Genescà","doi":"10.1038/s41575-024-00955-8","DOIUrl":"10.1038/s41575-024-00955-8","url":null,"abstract":"Although metabolic dysfunction-associated steatohepatitis (MASH) is rapidly becoming a leading cause of cirrhosis worldwide, therapeutic options are limited and the number of clinical trials in MASH-related compensated cirrhosis is low as compared to those conducted in earlier disease stages. Moreover, designing clinical trials in MASH cirrhosis presents a series of challenges regarding the understanding and conceptualization of the natural history, regulatory considerations, inclusion criteria, recruitment, end points and trial duration, among others. The first international workshop on the state of the art and future direction of clinical trials in MASH-related compensated cirrhosis was held in April 2023 at Vall d’Hebron University Hospital in Barcelona (Spain) and was attended by a group of international experts on clinical trials from academia, regulatory agencies and industry, encompassing expertise in MASH, cirrhosis, portal hypertension, and regulatory affairs. The presented Roadmap summarizes important content of the workshop on current status, regulatory requirements and end points in MASH-related compensated cirrhosis clinical trials, exploring alternative study designs and highlighting the challenges that should be considered for upcoming studies on MASH cirrhosis. Metabolic dysfunction-associated steatohepatitis (MASH), a primary cause of chronic liver disease (CLD), often leads to advanced CLD stages such as cirrhosis. This Roadmap summarizes the current landscape and challenges of MASH-related compensated cirrhosis clinical trials and explores a way forward for future studies.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 11","pages":"809-823"},"PeriodicalIF":45.9,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141631321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disability inclusion in research and health care 将残疾问题纳入研究和医疗保健
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-15 DOI: 10.1038/s41575-024-00958-5
Hannah Kuper, Tom Shakespeare
{"title":"Disability inclusion in research and health care","authors":"Hannah Kuper, Tom Shakespeare","doi":"10.1038/s41575-024-00958-5","DOIUrl":"10.1038/s41575-024-00958-5","url":null,"abstract":"Globally, one in six people have a disability, and individuals with disabilities often experience a narrow margin of health, less financial security and health disparities. We call for action to improve access to health care for people with disabilities and show how this plan might be achieved.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 9","pages":"601-602"},"PeriodicalIF":45.9,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141618351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fgfbp1+ cells: upper crypt intestinal epithelial regeneration Fgfbp1+ 细胞：上隐窝肠上皮再生
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-11 DOI: 10.1038/s41575-024-00965-6
Jordan Hindson
{"title":"Fgfbp1+ cells: upper crypt intestinal epithelial regeneration","authors":"Jordan Hindson","doi":"10.1038/s41575-024-00965-6","DOIUrl":"10.1038/s41575-024-00965-6","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 8","pages":"534-534"},"PeriodicalIF":45.9,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141584531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neoadjuvant immunotherapy for mismatch repair-deficient colon cancer: a phase II study 错配修复缺陷结肠癌的新辅助免疫疗法：II 期研究
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-11 DOI: 10.1038/s41575-024-00966-5
Jordan Hindson
{"title":"Neoadjuvant immunotherapy for mismatch repair-deficient colon cancer: a phase II study","authors":"Jordan Hindson","doi":"10.1038/s41575-024-00966-5","DOIUrl":"10.1038/s41575-024-00966-5","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 8","pages":"534-534"},"PeriodicalIF":45.9,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141584526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incretin-based therapies for liver disease 基于胰岛素的肝病疗法
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-08 DOI: 10.1038/s41575-024-00961-w
Eleni Kotsiliti
{"title":"Incretin-based therapies for liver disease","authors":"Eleni Kotsiliti","doi":"10.1038/s41575-024-00961-w","DOIUrl":"10.1038/s41575-024-00961-w","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 8","pages":"533-533"},"PeriodicalIF":45.9,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A bloody disgrace — time to change patient safety culture 血淋淋的耻辱--是改变患者安全文化的时候了
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-08 DOI: 10.1038/s41575-024-00957-6
Stuart Cantrill
{"title":"A bloody disgrace — time to change patient safety culture","authors":"Stuart Cantrill","doi":"10.1038/s41575-024-00957-6","DOIUrl":"10.1038/s41575-024-00957-6","url":null,"abstract":"After decades of institutional deceit, deflection, defensiveness and delay, publication of the final report of the Infected Blood Inquiry lays bare the failings of the British state and its National Health Service. Now, it is time for justice, accountability and a change in patient safety culture.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 8","pages":"530-530"},"PeriodicalIF":45.9,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141556765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ETS2 regulates human inflammatory macrophages in IBD ETS2 调节 IBD 中的人类炎症巨噬细胞
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-02 DOI: 10.1038/s41575-024-00960-x
Katrina Ray
{"title":"ETS2 regulates human inflammatory macrophages in IBD","authors":"Katrina Ray","doi":"10.1038/s41575-024-00960-x","DOIUrl":"10.1038/s41575-024-00960-x","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 8","pages":"534-534"},"PeriodicalIF":45.9,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141489616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digestive Disease Week 2024 2024 年消化系统疾病周
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-06-17 DOI: 10.1038/s41575-024-00954-9
Katrina Ray
{"title":"Digestive Disease Week 2024","authors":"Katrina Ray","doi":"10.1038/s41575-024-00954-9","DOIUrl":"10.1038/s41575-024-00954-9","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 8","pages":"534-534"},"PeriodicalIF":45.9,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141334420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Next generation of gastrointestinal electrophysiology devices 新一代胃肠电生理设备
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-06-14 DOI: 10.1038/s41575-024-00952-x
Haitao Liu, Siheng Sean You, Zhigang Gao, Ning Hu, Yunlong Zhao
{"title":"Next generation of gastrointestinal electrophysiology devices","authors":"Haitao Liu, Siheng Sean You, Zhigang Gao, Ning Hu, Yunlong Zhao","doi":"10.1038/s41575-024-00952-x","DOIUrl":"10.1038/s41575-024-00952-x","url":null,"abstract":"This Comment reviews the evolution from early electrophysiological studies to advanced diagnostic tools, highlighting the challenges and innovations shaping the future of gastrointestinal diagnostics.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 7","pages":"457-458"},"PeriodicalIF":45.9,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141319913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intermittent fasting for NASH and HCC in mice 间歇性禁食治疗小鼠 NASH 和 HCC
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-06-14 DOI: 10.1038/s41575-024-00953-w
Jordan Hindson
{"title":"Intermittent fasting for NASH and HCC in mice","authors":"Jordan Hindson","doi":"10.1038/s41575-024-00953-w","DOIUrl":"10.1038/s41575-024-00953-w","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 7","pages":"461-461"},"PeriodicalIF":45.9,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141319850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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