回复“将遗传变异纳入东亚人群酒精相关肝病试验”

IF 45.9 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-03-24 DOI:10.1038/s41575-025-01059-7

Mack C. Mitchell, Brian P. Lee, Jessica Mellinger, Laura E. Nagy

{"title":"回复“将遗传变异纳入东亚人群酒精相关肝病试验”","authors":"Mack C. Mitchell, Brian P. Lee, Jessica Mellinger, Laura E. Nagy","doi":"10.1038/s41575-025-01059-7","DOIUrl":null,"url":null,"abstract":"We thank Kang for their comments on our recent Consensus Statement (Lee, B. P. et al. Designing clinical trials to address alcohol use and alcohol-associated liver disease: an expert panel Consensus Statement. Nat. Rev. Gastroenterol. Hepatol. 21, 626–645 (2024))1 to incorporate genetic variations into consideration (Kang, B. Incorporating genetic variations in alcohol-associated liver disease trials for East Asian populations. Nat. Rev. Gastroenterol. Hepatol. https://doi.org/10.1038/s41575-025-01060-0 (2025))2. We agree that people who are deficient in ALDH2 and drink alcohol might be at increased risk of cancer of the upper digestive tract, oesophagus and liver. The increased risk of cancer in those who are ALDH2-deficient noted by Kang was not the focus of our initiative, but we appreciate the acknowledgement of the increased risk for this population.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"33 1","pages":""},"PeriodicalIF":45.9000,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Reply to ‘Incorporating genetic variations in alcohol-associated liver disease trials for East Asian populations’\",\"authors\":\"Mack C. Mitchell, Brian P. Lee, Jessica Mellinger, Laura E. Nagy\",\"doi\":\"10.1038/s41575-025-01059-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We thank Kang for their comments on our recent Consensus Statement (Lee, B. P. et al. Designing clinical trials to address alcohol use and alcohol-associated liver disease: an expert panel Consensus Statement. Nat. Rev. Gastroenterol. Hepatol. 21, 626–645 (2024))1 to incorporate genetic variations into consideration (Kang, B. Incorporating genetic variations in alcohol-associated liver disease trials for East Asian populations. Nat. Rev. Gastroenterol. Hepatol. https://doi.org/10.1038/s41575-025-01060-0 (2025))2. We agree that people who are deficient in ALDH2 and drink alcohol might be at increased risk of cancer of the upper digestive tract, oesophagus and liver. The increased risk of cancer in those who are ALDH2-deficient noted by Kang was not the focus of our initiative, but we appreciate the acknowledgement of the increased risk for this population.\",\"PeriodicalId\":18793,\"journal\":{\"name\":\"Nature Reviews Gastroenterology &Hepatology\",\"volume\":\"33 1\",\"pages\":\"\"},\"PeriodicalIF\":45.9000,\"publicationDate\":\"2025-03-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Reviews Gastroenterology &Hepatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41575-025-01059-7\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Gastroenterology &Hepatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41575-025-01059-7","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

我们感谢Kang对我们最近的共识声明（Lee, b.p. et al.）的评论。设计临床试验以解决酒精使用和酒精相关肝病：专家小组共识声明。Nat Rev. Gastroenterol。国际肝病杂志，21,626-645(2024))1纳入遗传变异考虑(Kang， B.纳入东亚人群酒精相关肝病试验的遗传变异。Nat Rev. Gastroenterol。乙醇。https://doi.org/10.1038/s41575 - 025 - 01060 - 0(2025)) 2。我们同意，缺乏ALDH2并饮酒的人患上消化道、食道癌和肝癌的风险可能会增加。Kang指出的aldh2缺陷患者癌症风险的增加并不是我们研究的重点，但我们对这一人群风险增加的认识表示赞赏。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Reply to ‘Incorporating genetic variations in alcohol-associated liver disease trials for East Asian populations’

We thank Kang for their comments on our recent Consensus Statement (Lee, B. P. et al. Designing clinical trials to address alcohol use and alcohol-associated liver disease: an expert panel Consensus Statement. Nat. Rev. Gastroenterol. Hepatol. 21, 626–645 (2024))¹ to incorporate genetic variations into consideration (Kang, B. Incorporating genetic variations in alcohol-associated liver disease trials for East Asian populations. Nat. Rev. Gastroenterol. Hepatol. https://doi.org/10.1038/s41575-025-01060-0 (2025))². We agree that people who are deficient in ALDH2 and drink alcohol might be at increased risk of cancer of the upper digestive tract, oesophagus and liver. The increased risk of cancer in those who are ALDH2-deficient noted by Kang was not the focus of our initiative, but we appreciate the acknowledgement of the increased risk for this population.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nature Reviews Gastroenterology &Hepatology 医学-胃肠肝病学

CiteScore

52.30

自引率

0.60%

发文量

147

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.