Nature Reviews Gastroenterology &Hepatology最新文献

Incorporating genetic variations in alcohol-associated liver disease trials for East Asian populations

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-03-24 DOI: 10.1038/s41575-025-01060-0

Bossng Kang

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Reply to ‘Incorporating genetic variations in alcohol-associated liver disease trials for East Asian populations’

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-03-24 DOI: 10.1038/s41575-025-01059-7

Mack C. Mitchell, Brian P. Lee, Jessica Mellinger, Laura E. Nagy

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Cell therapy for liver disorders: past, present and future

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-03-18 DOI: 10.1038/s41575-025-01050-2

M. Carmen Ortuño-Costela, Massimo Pinzani, Ludovic Vallier

{"title":"Cell therapy for liver disorders: past, present and future","authors":"M. Carmen Ortuño-Costela, Massimo Pinzani, Ludovic Vallier","doi":"10.1038/s41575-025-01050-2","DOIUrl":"https://doi.org/10.1038/s41575-025-01050-2","url":null,"abstract":"The liver fulfils a plethora of vital functions and, due to their importance, liver dysfunction has life-threatening consequences. Liver disorders currently account for more than two million deaths annually worldwide and can be classified broadly into three groups, considering their onset and aetiology, as acute liver diseases, inherited metabolic disorders and chronic liver diseases. In the most advanced and severe forms leading to liver failure, liver transplantation is the only treatment available, which has many associated drawbacks, including a shortage of organ donors. Cell therapy via fully mature cell transplantation is an advantageous alternative that may be able to restore a damaged organ’s functionality or serve as a bridge until regeneration can occur. Pioneering work has shown that transplanting adult hepatocytes can support liver recovery. However, primary hepatocytes cannot be grown extensively in vitro as they rapidly lose their metabolic activity. Therefore, different cell sources are currently being tested as alternatives to primary cells. Human pluripotent stem cell-derived cells, chemically induced liver progenitors, or ‘liver’ organoids, hold great promise for developing new cell therapies for acute and chronic liver diseases. This Review focuses on the advantages and drawbacks of distinct cell sources and the relative strategies to address different therapeutic needs in distinct liver diseases.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"7 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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EASL Liver Cancer Summit 2025

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-03-12 DOI: 10.1038/s41575-025-01057-9

Jordan Hindson

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Author Correction: Μetabolic dysfunction-associated steatotic liver disease: a condition of heterogeneous metabolic risk factors, mechanisms and comorbidities requiring holistic treatment

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-03-07 DOI: 10.1038/s41575-025-01056-w

Christopher D. Byrne, Angelo Armandi, Vanessa Pellegrinelli, Antonio Vidal-Puig, Elisabetta Bugianesi

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Estimating dietary intake from human stool DNA

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-03-07 DOI: 10.1038/s41575-025-01054-y

Katrina Ray

{"title":"Estimating dietary intake from human stool DNA","authors":"Katrina Ray","doi":"10.1038/s41575-025-01054-y","DOIUrl":"https://doi.org/10.1038/s41575-025-01054-y","url":null,"abstract":"Accurately determining dietary and nutrient intake in nutrition research is challenging, and usually reliant on self-reported methods such as dietary questionnaires that can introduce bias. A new study published in Nature Metabolism reports a method for quantifying food-derived DNA in human stool — Metagenomic Estimation of Dietary Intake (MEDI) — by examining faecal metagenomes. This new, semi-quantitative method could be an alternative approach for approximating dietary intake.Diener et al. constructed a comprehensive metagenomic food database (>450 foods mapped) and showed that DNA-containing food components can be detected in stool-derived metagenomic data, even at low abundance. Moreover, MEDI dietary intake profiles could be converted into detailed metabolic representations of nutrient intake. In validation experiments, MEDI estimates showed agreement with food and nutrient intake from two controlled-feeding studies and food frequency questionnaire data in infant and adult populations. Furthermore, as a proof-of-concept, the researchers demonstrated that specific dietary features associated with metabolic syndrome could be determined in a large clinical cohort (n = 533, 274 healthy individuals and 259 individuals with metabolic syndrome in the METACARDIS study) without dietary records.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"14 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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RNA vaccine induces long-lived anti-tumour T cells in pancreatic cancer

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-03-07 DOI: 10.1038/s41575-025-01055-x

Katrina Ray

{"title":"RNA vaccine induces long-lived anti-tumour T cells in pancreatic cancer","authors":"Katrina Ray","doi":"10.1038/s41575-025-01055-x","DOIUrl":"https://doi.org/10.1038/s41575-025-01055-x","url":null,"abstract":"Vaccines to treat cancer are currently in development, with the potential for personalized treatments targeting specific mutations in various cancer types. A previous phase I trial reported that a personalized RNA neoantigen vaccine was safe and stimulated anti-tumour CD8+ T cells in patients with pancreatic cancer that correlated with delayed recurrence of pancreatic adenocarcinoma (8 of 16, at 1.5-year follow-up). Patients underwent surgery and then treatment with atezolizumab (a PD-L1 inhibitory antibody), autogene cevumeran (a personalized neoantigen RNA vaccine) and modified FOLFIRINOX (chemotherapy). In this new study, published in Nature, the researchers analysed samples before and after treatment in an extended follow-up to further investigate the features of these vaccine-induced T cells.Treatment responders with vaccine-induced T cells (n = 8) had prolonged recurrence-free survival compared with non-responders without such T cells (median 13.4 months, P = 0.007), with 6 of the responders cancer-free at a median follow-up of 3.2 years. Autogene cevumeran induced long-lived and robust CD8+ T cell responses that correlated with delayed pancreatic adenocarcinoma recurrence at 3.2 years. Crucially, the vaccine induced long-lived T cell clones (with multi-year lifespans, median of 7.7 years) that persist as putative memory T cells and retained these effector functions long term. A global randomized phase II trial is now ongoing.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"3 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ECCO’25

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-03-06 DOI: 10.1038/s41575-025-01053-z

Eleni Kotsiliti

{"title":"ECCO’25","authors":"Eleni Kotsiliti","doi":"10.1038/s41575-025-01053-z","DOIUrl":"https://doi.org/10.1038/s41575-025-01053-z","url":null,"abstract":"In February 2025, Nature Reviews Gastroenterology & Hepatology attended the 20th Congress of the European Crohn’s and Colitis Organisation (ECCO’25) in Berlin, Germany. According to the organizers, 1,776 abstracts were submitted, of which 1,358 were posters and 176 were oral presentations. Compared with previous years, ECCO’25 had the highest attendance, with 8,156 delegates. This year, ECCO focused on the REACH goal for sustainability in the prevention and treatment of inflammatory bowel disease (IBD).Sections were dedicated to all things IBD, including nutrition, treatment strategies, surgery and endoscopy, and artificial intelligence tools. Single-cell RNA sequencing, multi-omics biomarkers and antibodies were among the research topics discussed, as well as combination therapy, personalized treatment and psychosocial factors associated with IBD. Richard Hansen and Vaios Svolos presented a summary of the upcoming ECCO consensus on diet and nutrition in IBD that involves, among others, diet recommendations for induction and maintenance. Roger Feakins, Torsten Kucharzik and Stuart Taylor presented a summary of the updated multi-society consensus on IBD diagnostic guidelines. In addition, notable trial results were presented, such as RELIEVE UCCD, GRAVITI and EFFICACI.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"4 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing an adaptive platform trial for evaluation of medical treatments for Crohn’s disease

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-03-05 DOI: 10.1038/s41575-025-01052-0

Nurulamin M. Noor, Shellie J. Radford, Babak Choodari-Oskooei, Morris Gordon, Ailsa L. Hart, Trish Hepburn, Ed Juszczak, James O. Lindsay, Nicholas A. Kennedy, Mahesh K. B. Parmar, Vipul Jairath, Gordon W. Moran

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A Consensus Statement on establishing causality, therapeutic applications and the use of preclinical models in microbiome research

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-03-03 DOI: 10.1038/s41575-025-01041-3

Amira Metwaly, Aicha Kriaa, Zahra Hassani, Federica Carraturo, Celine Druart, Kaline Arnauts, Paul Wilmes, Jens Walter, Stephan Rosshart, Mahesh S. Desai, Joel Dore, Hervé M. Blottiere, Emmanuelle Maguin, Dirk Haller

{"title":"A Consensus Statement on establishing causality, therapeutic applications and the use of preclinical models in microbiome research","authors":"Amira Metwaly, Aicha Kriaa, Zahra Hassani, Federica Carraturo, Celine Druart, Kaline Arnauts, Paul Wilmes, Jens Walter, Stephan Rosshart, Mahesh S. Desai, Joel Dore, Hervé M. Blottiere, Emmanuelle Maguin, Dirk Haller","doi":"10.1038/s41575-025-01041-3","DOIUrl":"https://doi.org/10.1038/s41575-025-01041-3","url":null,"abstract":"The gut microbiome comprises trillions of microorganisms and profoundly influences human health by modulating metabolism, immune responses and neuronal functions. Disruption in gut microbiome composition is implicated in various inflammatory conditions, metabolic disorders and neurodegenerative diseases. However, determining the underlying mechanisms and establishing cause and effect is extremely difficult. Preclinical models offer crucial insights into the role of the gut microbiome in diseases and help identify potential therapeutic interventions. The Human Microbiome Action Consortium initiated a Delphi survey to assess the utility of preclinical models, including animal and cell-based models, in elucidating the causal role of the gut microbiome in these diseases. The Delphi survey aimed to address the complexity of selecting appropriate preclinical models to investigate disease causality and to study host–microbiome interactions effectively. We adopted a structured approach encompassing a literature review, expert workshops and the Delphi questionnaire to gather insights from a diverse range of stakeholders. Experts were requested to evaluate the strengths, limitations, and suitability of these models in addressing the causal relationship between the gut microbiome and disease pathogenesis. The resulting consensus statements and recommendations provide valuable insights for selecting preclinical models in future studies of gut microbiome-related diseases.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"130 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0