Nature Reviews Gastroenterology &Hepatology最新文献_第10页

EPC 2024 EPC 2024。

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-08-12 DOI: 10.1038/s41575-024-00979-0

Jordan Hindson

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Cellular and molecular basis of proximal small intestine disorders 近端小肠疾病的细胞和分子基础

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-08-08 DOI: 10.1038/s41575-024-00962-9

Tania Bildstein, Fabienne Charbit-Henrion, Aline Azabdaftari, Nadine Cerf-Bensussan, Holm H. Uhlig

{"title":"Cellular and molecular basis of proximal small intestine disorders","authors":"Tania Bildstein, Fabienne Charbit-Henrion, Aline Azabdaftari, Nadine Cerf-Bensussan, Holm H. Uhlig","doi":"10.1038/s41575-024-00962-9","DOIUrl":"10.1038/s41575-024-00962-9","url":null,"abstract":"The proximal part of the small intestine, including duodenum and jejunum, is not only dedicated to nutrient digestion and absorption but is also a highly regulated immune site exposed to environmental factors. Host-protective responses against pathogens and tolerance to food antigens are essential functions in the small intestine. The cellular ecology and molecular pathways to maintain those functions are complex. Maladaptation is highlighted by common immune-mediated diseases such as coeliac disease, environmental enteric dysfunction or duodenal Crohn’s disease. An expanding spectrum of more than 100 rare monogenic disorders inform on causative molecular mechanisms of nutrient absorption, epithelial homeostasis and barrier function, as well as inflammatory immune responses and immune regulation. Here, after summarizing the architectural and cellular traits that underlie the functions of the proximal intestine, we discuss how the integration of tissue immunopathology and molecular mechanisms can contribute towards our understanding of disease and guide diagnosis. We propose an integrated mechanism-based taxonomy and discuss the latest experimental approaches to gain new mechanistic insight into these disorders with large disease burden worldwide as well as implications for therapeutic interventions. The proximal small intestine is key for nutrition, metabolism and immune responses, and can be affected by a wide range of disorders. This Review describes the cellular and molecular bases of diseases of the proximal small intestine (including rare monogenic disorders), proposing a mechanism-based taxonomy.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 10","pages":"687-709"},"PeriodicalIF":45.9,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141904647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Risankizumab versus ustekinumab for Crohn’s disease: a phase IIIb study 利桑珠单抗与乌司他单抗治疗克罗恩病：IIIb 期研究

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-08-05 DOI: 10.1038/s41575-024-00973-6

Eleni Kotsiliti

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EASL Congress 2024 2024 年 EASL 大会

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-08-05 DOI: 10.1038/s41575-024-00971-8

Eleni Kotsiliti

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Metastatic pancreatic cancer and the liver 转移性胰腺癌和肝脏

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-08-05 DOI: 10.1038/s41575-024-00972-7

Eleni Kotsiliti

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Author Correction: A roadmap for clinical trials in MASH-related compensated cirrhosis 作者更正：MASH 相关代偿性肝硬化临床试验路线图。

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-08-05 DOI: 10.1038/s41575-024-00976-3

Juan M. Pericàs, Quentin M. Anstee, Salvador Augustin, Ramón Bataller, Annalisa Berzigotti, Andreea Ciudin, Sven Francque, Juan G. Abraldes, Virginia Hernández-Gea, Mònica Pons, Thomas Reiberger, Ian A. Rowe, Peter Rydqvist, Elmer Schabel, Frank Tacke, Emmanuel A. Tsochatzis, Joan Genescà

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Food inequity and insecurity and MASLD: burden, challenges, and interventions 粮食不公平和不安全与 MASLD：负担、挑战和干预措施

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-29 DOI: 10.1038/s41575-024-00959-4

Shira Zelber-Sagi, Patrizia Carrieri, Juan M. Pericàs, Dana Ivancovsky-Wajcman, Zobair M. Younossi, Jeffrey V. Lazarus

{"title":"Food inequity and insecurity and MASLD: burden, challenges, and interventions","authors":"Shira Zelber-Sagi, Patrizia Carrieri, Juan M. Pericàs, Dana Ivancovsky-Wajcman, Zobair M. Younossi, Jeffrey V. Lazarus","doi":"10.1038/s41575-024-00959-4","DOIUrl":"10.1038/s41575-024-00959-4","url":null,"abstract":"Liver disease prevalence, severity, outcomes and hepatic risk factors (for example, unhealthy diet) are heavily affected by socioeconomic status and food insecurity. Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent liver disease globally and is likely to co-occur with other liver diseases associated with food insecurity. Though weight reduction and adopting a healthy diet can reverse the course of MASLD, gaps between recommendations and practice transcend individual responsibility and preference. Broader sociocultural determinants of food choices (social nutrition) include food insecurity, community and social norms and the local environment, including commercial pressures that target people experiencing poverty, ethnic minorities and children. Food insecurity is a barrier to a healthy diet, as a low-quality diet is often less expensive than a healthy one. Consequently, food insecurity is an ‘upstream’ risk factor for MASLD, advanced fibrosis and greater all-cause mortality among patients with liver disease. Intervening on food insecurity at four major levels (environment, policy, community and health care) can reduce the burden of liver disease, thereby reducing social and health inequities. In this Review, we report on the current research in the field, the need for implementing proven interventions, and the role liver specialists can have. Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is increasing worldwide, and a crucial risk factor is food insecurity. This Review provides an extensive overview of food insecurity in the context of MASLD and discusses potential policies and procedures as interventions.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 10","pages":"668-686"},"PeriodicalIF":45.9,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41575-024-00959-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141791009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Mother-to-child transmission of hepatitis B: current status and the road forward 乙型肝炎的母婴传播：现状与未来之路

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-28 DOI: 10.1038/s41575-024-00956-7

Yvonne A. Nartey, Ansumana S. Bockarie

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Viral hepatitis elimination — time to act 消除病毒性肝炎--是时候采取行动了

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-28 DOI: 10.1038/s41575-024-00963-8

引用次数: 0

Western lifestyle, metaflammation and the cell of origin of colon cancer 西方生活方式、元炎症和结肠癌的起源细胞

IF 45.9 1区医学