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The changing metabolic landscape of bile acids – keys to metabolism and immune regulation 不断变化的胆汁酸代谢状况--新陈代谢和免疫调节的关键
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-04-04 DOI: 10.1038/s41575-024-00914-3
Ipsita Mohanty, Celeste Allaband, Helena Mannochio-Russo, Yasin El Abiead, Lee R. Hagey, Rob Knight, Pieter C. Dorrestein
{"title":"The changing metabolic landscape of bile acids – keys to metabolism and immune regulation","authors":"Ipsita Mohanty, Celeste Allaband, Helena Mannochio-Russo, Yasin El Abiead, Lee R. Hagey, Rob Knight, Pieter C. Dorrestein","doi":"10.1038/s41575-024-00914-3","DOIUrl":"10.1038/s41575-024-00914-3","url":null,"abstract":"Bile acids regulate nutrient absorption and mitochondrial function, they establish and maintain gut microbial community composition and mediate inflammation, and they serve as signalling molecules that regulate appetite and energy homeostasis. The observation that there are hundreds of bile acids, especially many amidated bile acids, necessitates a revision of many of the classical descriptions of bile acids and bile acid enzyme functions. For example, bile salt hydrolases also have transferase activity. There are now hundreds of known modifications to bile acids and thousands of bile acid-associated genes, especially when including the microbiome, distributed throughout the human body (for example, there are >2,400 bile salt hydrolases alone). The fact that so much of our genetic and small-molecule repertoire, in both amount and diversity, is dedicated to bile acid function highlights the centrality of bile acids as key regulators of metabolism and immune homeostasis, which is, in large part, communicated via the gut microbiome. Bile acids have important roles in human metabolism and immune regulation. In this Perspective, Dorrestein and colleagues discuss the technologies and data science-related approaches that are improving our understanding of the diversity of bile acids and their multifaceted roles.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":45.9,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140346182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Publisher Correction: Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis 出版商更正：胃肠道与大脑屏障：打开微生物群-肠-脑轴之间的交流之门
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-04-04 DOI: 10.1038/s41575-024-00929-w
María R. Aburto, John F. Cryan
{"title":"Publisher Correction: Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis","authors":"María R. Aburto, John F. Cryan","doi":"10.1038/s41575-024-00929-w","DOIUrl":"10.1038/s41575-024-00929-w","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":65.1,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41575-024-00929-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140814314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving culturally safe engagement with sexual and gender minority populations 改善与性少数群体和性别少数群体的文化安全接触
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-04-02 DOI: 10.1038/s41575-024-00927-y
Newsha Nikzad, Nikki Duong, Sonali Paul
{"title":"Improving culturally safe engagement with sexual and gender minority populations","authors":"Newsha Nikzad, Nikki Duong, Sonali Paul","doi":"10.1038/s41575-024-00927-y","DOIUrl":"10.1038/s41575-024-00927-y","url":null,"abstract":"Cultural safety seeks to remediate health inequities through empowering marginalized and minoritized patient populations, minimizing implicit bias and incorporating social determinants of health into practice. Here, we propose a cultural safety framework to guide communication with patients from sexual and gender minorities.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":65.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140340781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New understanding of hepatobiliary MRI 肝胆磁共振成像的新认识
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-04-02 DOI: 10.1038/s41575-024-00926-z
Catherine M. Pastor, Valérie Vilgrain
{"title":"New understanding of hepatobiliary MRI","authors":"Catherine M. Pastor, Valérie Vilgrain","doi":"10.1038/s41575-024-00926-z","DOIUrl":"10.1038/s41575-024-00926-z","url":null,"abstract":"Magnetic resonance imaging following injection of hepatobiliary contrast agents improves the detection of hepatocellular carcinomas when contrast agent accumulations in tumours and the surrounding pathological liver differ. However, tissue accumulation is poorly investigated, and this Clinical Outlook article highlights experimental data to understand better contrast agent accumulation in human pathological livers.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":45.9,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140340782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tackling sorbitol intolerance 解决山梨醇不耐受问题
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-03-25 DOI: 10.1038/s41575-024-00921-4
Maria Papatriantafyllou
{"title":"Tackling sorbitol intolerance","authors":"Maria Papatriantafyllou","doi":"10.1038/s41575-024-00921-4","DOIUrl":"10.1038/s41575-024-00921-4","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":65.1,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140209840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacteriophages and host inflammation in IBD 噬菌体与 IBD 中的宿主炎症
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-03-22 DOI: 10.1038/s41575-024-00925-0
Eleni Kotsiliti
{"title":"Bacteriophages and host inflammation in IBD","authors":"Eleni Kotsiliti","doi":"10.1038/s41575-024-00925-0","DOIUrl":"10.1038/s41575-024-00925-0","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":65.1,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140192591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Seladelpar in primary biliary cholangitis 原发性胆汁性胆管炎中的 Seladelpar。
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-03-22 DOI: 10.1038/s41575-024-00922-3
Eleni Kotsiliti
{"title":"Seladelpar in primary biliary cholangitis","authors":"Eleni Kotsiliti","doi":"10.1038/s41575-024-00922-3","DOIUrl":"10.1038/s41575-024-00922-3","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":65.1,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140194192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HCC genomic landscape in Chinese individuals 中国人的 HCC 基因组状况
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-03-22 DOI: 10.1038/s41575-024-00924-1
Eleni Kotsiliti
{"title":"HCC genomic landscape in Chinese individuals","authors":"Eleni Kotsiliti","doi":"10.1038/s41575-024-00924-1","DOIUrl":"10.1038/s41575-024-00924-1","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":65.1,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140192677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomarker shows no clinical use in guiding treatment for Crohn’s disease 生物标志物在指导克罗恩病治疗方面没有临床用途
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-03-22 DOI: 10.1038/s41575-024-00923-2
Eleni Kotsiliti
{"title":"Biomarker shows no clinical use in guiding treatment for Crohn’s disease","authors":"Eleni Kotsiliti","doi":"10.1038/s41575-024-00923-2","DOIUrl":"10.1038/s41575-024-00923-2","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":65.1,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140192641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Towards unifying fatty liver nomenclature: a voice from the Middle East and North Africa 统一脂肪肝命名法：来自中东和北非的声音
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-03-18 DOI: 10.1038/s41575-024-00918-z
Yasser Fouad, Salma Barakat, Almoutaz Hashim, Hasmik Ghazinyan
{"title":"Towards unifying fatty liver nomenclature: a voice from the Middle East and North Africa","authors":"Yasser Fouad, Salma Barakat, Almoutaz Hashim, Hasmik Ghazinyan","doi":"10.1038/s41575-024-00918-z","DOIUrl":"10.1038/s41575-024-00918-z","url":null,"abstract":"Fatty liver disease is one of the most common liver diseases in the Middle East and North Africa region, and globally. Unfortunately, there is a lack of awareness regarding this condition. The nomenclature changes for NAFLD (to MAFLD or MASLD) have gained considerable attention in the hepatology community. Here, we present our point of view on this ongoing change and debate.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":65.1,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140146073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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