Nature Reviews Gastroenterology &Hepatology最新文献_第9页

A gut–liver axis in intestinal stem cell fitness 肠道干细胞健康的肠道-肝脏轴。

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-02-14 DOI: 10.1038/s41575-024-00910-7

Katrina Ray

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Sugemalimab with chemotherapy for advanced ESCC 苏格玛单抗联合化疗治疗晚期 ESCC

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-02-14 DOI: 10.1038/s41575-024-00912-5

Katrina Ray

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Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis 胃肠道和大脑屏障：打开微生物群-肠-脑轴之间的沟通之门。

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-02-14 DOI: 10.1038/s41575-023-00890-0

María R. Aburto, John F. Cryan

{"title":"Gastrointestinal and brain barriers: unlocking gates of communication across the microbiota–gut–brain axis","authors":"María R. Aburto, John F. Cryan","doi":"10.1038/s41575-023-00890-0","DOIUrl":"10.1038/s41575-023-00890-0","url":null,"abstract":"Crosstalk between gut and brain has long been appreciated in health and disease, and the gut microbiota is a key player in communication between these two distant organs. Yet, the mechanisms through which the microbiota influences development and function of the gut–brain axis remain largely unknown. Barriers present in the gut and brain are specialized cellular interfaces that maintain strict homeostasis of different compartments across this axis. These barriers include the gut epithelial barrier, the blood–brain barrier and the blood–cerebrospinal fluid barrier. Barriers are ideally positioned to receive and communicate gut microbial signals constituting a gateway for gut–microbiota–brain communication. In this Review, we focus on how modulation of these barriers by the gut microbiota can constitute an important channel of communication across the gut–brain axis. Moreover, barrier malfunction upon alterations in gut microbial composition could form the basis of various conditions, including often comorbid neurological and gastrointestinal disorders. Thus, we should focus on unravelling the molecular and cellular basis of this communication and move from simplistic framing as ‘leaky gut’. A mechanistic understanding of gut microbiota modulation of barriers, especially during critical windows of development, could be key to understanding the aetiology of gastrointestinal and neurological disorders. The gut microbiota is an important modulator of the gut–brain axis. This Review provides an overview of barrier function across this axis and examines the role of the gut microbiota in communication across and between these specialized gastrointestinal and brain barriers in health and disease.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":65.1,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41575-023-00890-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139735644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sintilimab as adjuvant therapy for patients with resected HCC at high risk of recurrence 将辛替利马单抗作为辅助疗法，用于高复发风险的切除型 HCC 患者

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-02-12 DOI: 10.1038/s41575-024-00904-5

Jordan Hindson

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HCV direct-acting antiviral therapy adherence in people who inject drugs 注射吸毒者坚持接受 HCV 直接作用抗病毒疗法的情况

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-02-12 DOI: 10.1038/s41575-024-00905-4

Jordan Hindson

引用次数: 0

Linaclotide for functional constipation in paediatric patients: phase III results 利那洛肽治疗儿科功能性便秘：III 期研究结果

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-02-12 DOI: 10.1038/s41575-024-00903-6

Jordan Hindson

引用次数: 0

Evidence-based alcohol policies are the answer 基于证据的酒精政策是答案

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-02-09 DOI: 10.1038/s41575-024-00898-0

William Gilmore, Ian Gilmore

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Tolerance-inducing therapies in coeliac disease — mechanisms, progress and future directions 乳糜泻的耐受诱导疗法--机制、进展和未来方向

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-02-09 DOI: 10.1038/s41575-024-00895-3

Ludvig M. Sollid

{"title":"Tolerance-inducing therapies in coeliac disease — mechanisms, progress and future directions","authors":"Ludvig M. Sollid","doi":"10.1038/s41575-024-00895-3","DOIUrl":"10.1038/s41575-024-00895-3","url":null,"abstract":"Coeliac disease is an autoinflammatory condition caused by immune reactions to cereal gluten proteins. Currently, the only available treatment for the condition is a lifelong avoidance of gluten proteins in the diet. There is an unmet need for alternative therapies. Coeliac disease has a strong association with certain HLA−DQ allotypes (DQ2.5, DQ2.2 and DQ8), and these disease-associated HLA-DQ molecules present deamidated gluten peptides to gluten-specific CD4+ T cells. The gluten-specific CD4+ T cells are the drivers of the immune reactions leading to coeliac disease. Once established, the clonotypes of gluten-specific CD4+ T cells persist for decades, explaining why patients must adhere to a gluten-free diet for life. Given the key pathogenic role of gluten-specific CD4+ T cells, tolerance-inducing therapies that target these T cells are attractive for treatment of the disorder. Lessons learned from coeliac disease might provide clues for treatment of other HLA-associated diseases for which the disease-driving antigens are unknown. Thus, intensive efforts have been and are currently implemented to bring an effective tolerance-inducing therapy for coeliac disease. This Review discusses mechanisms of the various approaches taken, summarizing the progress made, and highlights future directions in this field. Coeliac disease is an autoinflammatory disease, with the only available treatment being a lifelong gluten-free diet. Alternative therapeutic approaches are needed. This Review explores the concept of tolerance-inducing therapies for coeliac disease, highlighting the underlying mechanisms, progress, challenges and future directions.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":65.1,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139710792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of dietary fibre on metabolic health and obesity 膳食纤维对代谢健康和肥胖症的影响。

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-02-07 DOI: 10.1038/s41575-023-00891-z

Edward C. Deehan, Valentin Mocanu, Karen L. Madsen

{"title":"Effects of dietary fibre on metabolic health and obesity","authors":"Edward C. Deehan, Valentin Mocanu, Karen L. Madsen","doi":"10.1038/s41575-023-00891-z","DOIUrl":"10.1038/s41575-023-00891-z","url":null,"abstract":"Obesity and metabolic syndrome represent a growing epidemic worldwide. Body weight is regulated through complex interactions between hormonal, neural and metabolic pathways and is influenced by numerous environmental factors. Imbalances between energy intake and expenditure can occur due to several factors, including alterations in eating behaviours, abnormal satiation and satiety, and low energy expenditure. The gut microbiota profoundly affects all aspects of energy homeostasis through diverse mechanisms involving effects on mucosal and systemic immune, hormonal and neural systems. The benefits of dietary fibre on metabolism and obesity have been demonstrated through mechanistic studies and clinical trials, but many questions remain as to how different fibres are best utilized in managing obesity. In this Review, we discuss the physiochemical properties of different fibres, current findings on how fibre and the gut microbiota interact to regulate body weight homeostasis, and knowledge gaps related to using dietary fibres as a complementary strategy. Precision medicine approaches that utilize baseline microbiota and clinical characteristics to predict individual responses to fibre supplementation represent a new paradigm with great potential to enhance weight management efficacy, but many challenges remain before these approaches can be fully implemented. Obesity and metabolic syndrome are two complex and multifactorial conditions. This Review provides a comprehensive overview of dietary fibres, discussing physiochemical properties, microbiota interactions and therapeutic interventions for body weight and insulin resistance regulation.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":65.1,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139702978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Connecting with the community 与社区建立联系。

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-02-07 DOI: 10.1038/s41575-024-00902-7

引用次数: 0