神经免疫相互作用影响空腹小鼠胰高血糖素分泌

IF 51 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-02-12 DOI:10.1038/s41575-025-01049-9

Jordan Hindson

引用次数: 0

摘要

在发表在《科学》杂志上的一项新研究中，研究人员在小鼠身上发现了一种机制，通过这种机制，神经系统和免疫系统相互作用，通过控制胰高血糖素的分泌来调节血糖水平。首先，他们观察到没有适应性淋巴细胞和先天淋巴样细胞（ILCs）（Rag2−/−Il2rg−/−）的小鼠在禁食期间血糖和胰高血糖素水平降低。但在缺乏适应性淋巴细胞的小鼠中没有观察到这种效应，适应性淋巴细胞暗示ILCs参与葡萄糖调节。具体而言，将2组ILCs （ILC2s）移植到缺乏淋巴细胞的小鼠体内，可增加空腹血糖水平和胰高血糖素（一种调节血糖水平的激素）的分泌。体外观察表明，胰岛il - c2s产生的细胞因子增加了朗格汉斯胰岛α-细胞分泌胰高血糖素。

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Neuroimmune interactions influence pancreatic glucagon secretion in fasting mice

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来源期刊

Nature Reviews Gastroenterology &Hepatology 医学-胃肠肝病学

CiteScore

52.30

自引率

0.60%

发文量

147

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.