Intestinal pH: a major driver of human gut microbiota composition and metabolism

IF 45.9 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Julius E. Brinck, Anurag K. Sinha, Martin F. Laursen, Lars O. Dragsted, Jeroen Raes, Ruben Vazquez Uribe, Jens Walter, Henrik M. Roager, Tine R. Licht
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Abstract

In the human gastrointestinal tract, pH is a key factor in shaping gut microbial composition and activity, while also being influenced by microbial metabolism. pH varies substantially along the gastrointestinal tract within an individual and between different individuals due to a combination of host, diet, microbial and external factors. The importance of pH on microbiota composition and metabolic response has been widely explored over the past century. Here, we review the literature to explore the major physiological and dietary factors that influence pH along the gastrointestinal tract. From a microbial ecology perspective, we discuss how gastrointestinal pH affects microbiota composition and metabolism. We explore mechanisms by which pH can influence bacterial acid response systems, gene expression and the production of microbial metabolites important for health. Finally, we review the literature regarding the potential role of gastrointestinal pH in human diseases. We propose that we can advance our understanding of the gut microbiota in health and disease by considering gastrointestinal pH. We argue that pH-mediated gut microbial metabolic variation is highly important for predicting and manipulating metabolic output relevant to human health.

Abstract Image

肠道pH值:人类肠道菌群组成和代谢的主要驱动因素
在人体胃肠道中,pH值是塑造肠道微生物组成和活性的关键因素,同时也受到微生物代谢的影响。由于宿主、饮食、微生物和外部因素的综合作用,pH值在个体内和不同个体之间沿着胃肠道变化很大。在过去的一个世纪里,pH对微生物群组成和代谢反应的重要性得到了广泛的探讨。在此,我们回顾文献,探讨影响胃肠道pH值的主要生理和饮食因素。从微生物生态学的角度,我们讨论了胃肠道pH值如何影响微生物群组成和代谢。我们探索了pH值影响细菌酸反应系统、基因表达和对健康重要的微生物代谢物产生的机制。最后,我们回顾了有关胃肠道pH值在人类疾病中的潜在作用的文献。我们建议,我们可以通过考虑胃肠道ph来推进我们对健康和疾病中肠道微生物群的理解。我们认为ph介导的肠道微生物代谢变异对于预测和操纵与人类健康相关的代谢输出非常重要。
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来源期刊
CiteScore
52.30
自引率
0.60%
发文量
147
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.
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