Reply to ‘Pregnancy and liver health: delivering new collaborations to advance the MASLD and MASH field’

IF 45.9 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-06-27 DOI:10.1038/s41575-025-01095-3

Alina M. Allen, Jeffrey V. Lazarus

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引用次数: 0

Abstract

We thank Borges Manna and Ovadia for their comments on our recent Perspective (Envisioning how to advance the MASH field. Nat. Rev. Gastroenterol. Hepatol. 21, 726–738 (2024))¹ and for highlighting the importance of including pregnancy as a lens through which to further the MASLD public health agenda (Pregnancy and liver health: delivering new collaborations to advance the MASLD and MASH field. Nat. Rev. Gastroenterol. Hepatol. https://doi.org/10.1038/s41575-025-01094-4 (2025))².

Metabolic dysfunction-associated steatotic liver disease (MASLD; formerly known as nonalcoholic fatty liver disease)³ is now the leading cause of end-stage liver disease requiring liver transplantation in women⁴. Owing to its slow progression, early identification — potentially decades before complications arise — presents a critical opportunity for timely intervention to prevent cirrhosis, adverse outcomes and mortality. Though rare, cirrhosis in pregnancy worsens fetal outcomes⁵. Antenatal and postpartum periods present ideal windows for early detection.

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回复“妊娠和肝脏健康：提供新的合作以推进MASLD和MASH领域”

我们感谢Borges Manna和Ovadia对我们最近的展望（设想如何推进MASH领域）的评论。Nat Rev. Gastroenterol。《国际肝病》，21,726-738(2024))1，并强调将妊娠作为进一步推进MASLD公共卫生议程的镜头的重要性（妊娠和肝脏健康：提供新的合作以推进MASLD和MASH领域）。Nat Rev. Gastroenterol。乙醇。https://doi.org/10.1038/s41575 - 025 - 01094 - 4(2025)) 2。代谢功能障碍相关脂肪变性肝病（MASLD）；以前被称为非酒精性脂肪性肝病(3)，现在是女性需要肝移植的终末期肝病的主要原因。由于其进展缓慢，早期识别（可能在并发症出现前几十年）为及时干预以预防肝硬化、不良后果和死亡率提供了关键机会。妊娠期肝硬化虽然罕见，但会使胎儿的预后恶化。产前和产后是早期发现的理想窗口期。

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来源期刊

Nature Reviews Gastroenterology &Hepatology 医学-胃肠肝病学

CiteScore

52.30

自引率

0.60%

发文量

147

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.