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AI-enabled ‘endo-histo-omics’: breaking down intestinal barriers in IBD 人工智能 "肠组织组学"：打破肠道疾病的肠道屏障
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-03-03 DOI: 10.1038/s41575-025-01051-1
Marietta Iacucci, Yasuharu Maeda, Giovanni Santacroce, Subrata Ghosh
{"title":"AI-enabled ‘endo-histo-omics’: breaking down intestinal barriers in IBD","authors":"Marietta Iacucci, Yasuharu Maeda, Giovanni Santacroce, Subrata Ghosh","doi":"10.1038/s41575-025-01051-1","DOIUrl":"https://doi.org/10.1038/s41575-025-01051-1","url":null,"abstract":"The AI-driven ‘endo-histo-omics’ approach integrates clinical, endoscopic, histological and molecular data to improve management of inflammatory bowel disease. This strategy enables precise patient stratification and outcome prediction, paving the way for advanced intestinal barrier assessment and restoration, thereby driving progress in personalized care.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"195 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reframing obesity and MASLD
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-02-28 DOI: 10.1038/s41575-025-01046-y
{"title":"Reframing obesity and MASLD","authors":"","doi":"10.1038/s41575-025-01046-y","DOIUrl":"10.1038/s41575-025-01046-y","url":null,"abstract":"As the burden of obesity and metabolic dysfunction-associated steatotic liver disease increases, the focus is shifting to the wide spectrum of disease, more accurate diagnostic criteria and the systems that influence our health to advance care.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"22 3","pages":"147-147"},"PeriodicalIF":45.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41575-025-01046-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clusters of metabolic dysfunction-associated steatotic liver disease for precision medicine
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-02-26 DOI: 10.1038/s41575-025-01048-w
Norbert Stefan, Giovanni Targher
{"title":"Clusters of metabolic dysfunction-associated steatotic liver disease for precision medicine","authors":"Norbert Stefan, Giovanni Targher","doi":"10.1038/s41575-025-01048-w","DOIUrl":"10.1038/s41575-025-01048-w","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous disease regarding its pathophysiology and clinical outcomes. Two novel studies suggest that different clusters of people with MASLD exist, explaining part of this heterogeneity. These findings and future research applying data dimensionality reduction approaches might be beneficial for implementing precision medicine in MASLD.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"22 4","pages":"226-227"},"PeriodicalIF":45.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Helicobacter pylori, microbiota and gastric cancer — principles of microorganism-driven carcinogenesis
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-02-26 DOI: 10.1038/s41575-025-01042-2
Jonas Wizenty, Michael Sigal
{"title":"Helicobacter pylori, microbiota and gastric cancer — principles of microorganism-driven carcinogenesis","authors":"Jonas Wizenty, Michael Sigal","doi":"10.1038/s41575-025-01042-2","DOIUrl":"https://doi.org/10.1038/s41575-025-01042-2","url":null,"abstract":"<p>The demonstration that <i>Helicobacter pylori</i> is a pathogenic bacterium with marked carcinogenic potential has paved the way for new preventive approaches for gastric cancer. Although decades of research have uncovered complex interactions of <i>H. pylori</i> with epithelial cells, current insights have refined our view on <i>H. pylori</i>-associated carcinogenesis. Specifically, the cell-type-specific effects on gastric stem and progenitor cells deep in gastric glands provide a new view on the ability of the bacteria to colonize long-term, manipulate host responses and promote gastric pathology. Furthermore, new, large-scale epidemiological data have shed light on factors that determine why only a subset of carriers progress to gastric cancer. Currently, technological advances have brought yet another revelation: <i>H. pylori</i> is far from the only microorganism able to colonize the stomach. Instead, the stomach is colonized by a diverse gastric microbiota, and there is emerging evidence for the occurrence and pathological effect of dysbiosis resulting from an aberrant interplay between <i>H. pylori</i> and the gastric mucosa. With the weight of this evidence mounting, here we consider how the lessons learned from <i>H. pylori</i> research inform and synergize with this emerging field to bring a more comprehensive understanding of the role of microbes in gastric carcinogenesis.</p>","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"22 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of biological sex in inflammatory bowel diseases
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-02-17 DOI: 10.1038/s41575-025-01038-y
Diane M. Tshikudi, Charles N. Bernstein, Suresh Mishra, Jean-Eric Ghia, Heather K. Armstrong
{"title":"Influence of biological sex in inflammatory bowel diseases","authors":"Diane M. Tshikudi, Charles N. Bernstein, Suresh Mishra, Jean-Eric Ghia, Heather K. Armstrong","doi":"10.1038/s41575-025-01038-y","DOIUrl":"https://doi.org/10.1038/s41575-025-01038-y","url":null,"abstract":"<p>The incidence of inflammatory bowel disease (IBD) has risen in the past decades and has emerged as a global health issue. IBD is characterized by chronic inflammation of the gastrointestinal tract. There is compelling evidence for the role of biological sex in IBD epidemiology, pathophysiology, disease progression, symptoms and extra-intestinal diseases. IBD disease course, management and therapies differ between men and women, yet there is a paucity of analysis of sex as a factor. This Review discusses the known influence of sex-linked genetic factors, hormones and hormone receptors in IBD incidence, prevalence, disease burden and clinical manifestation. Furthermore, we review the mechanisms underlying these sex-dependent effects on the dysregulation of gastrointestinal mucosal immunity (immune, epithelial barrier and microbiota) in IBD. To support the progressive inclusion of sex in the study of IBD, we summarize the current standard research methodology that should be implemented to investigate sex as a biological variable in IBD studies. Enhanced comprehension of the influence of sex in IBD pathophysiology will advance the development of targeted therapies and improve patient care.</p>","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"11 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Μetabolic dysfunction-associated steatotic liver disease: a condition of heterogeneous metabolic risk factors, mechanisms and comorbidities requiring holistic treatment
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-02-17 DOI: 10.1038/s41575-025-01045-z
Christopher D. Byrne, Angelo Armandi, Vanessa Pellegrinelli, Antonio Vidal-Puig, Elisabetta Bugianesi
{"title":"Μetabolic dysfunction-associated steatotic liver disease: a condition of heterogeneous metabolic risk factors, mechanisms and comorbidities requiring holistic treatment","authors":"Christopher D. Byrne, Angelo Armandi, Vanessa Pellegrinelli, Antonio Vidal-Puig, Elisabetta Bugianesi","doi":"10.1038/s41575-025-01045-z","DOIUrl":"https://doi.org/10.1038/s41575-025-01045-z","url":null,"abstract":"<p>Μetabolic dysfunction-associated steatotic liver disease (MASLD) comprises a heterogeneous condition in the presence of steatotic liver. There can be a hierarchy of metabolic risk factors contributing to the severity of metabolic dysfunction and, thereby, the associated risk of both liver and extrahepatic outcomes, but the precise ranking and combination of metabolic syndrome (MetS) traits that convey the highest risk of major adverse liver outcomes and extrahepatic disease complications remains uncertain. Insulin resistance, low-grade inflammation, atherogenic dyslipidaemia and hypertension are key to the mechanisms of liver and extrahepatic complications. The liver is pivotal in MetS progression as it regulates lipoprotein metabolism and secretes substances that affect insulin sensitivity and inflammation. MASLD affects the kidneys, heart and the vascular system, contributing to hypertension and oxidative stress. To address the global health burden of MASLD, intensified by obesity and type 2 diabetes mellitus epidemics, a holistic, multidisciplinary approach is essential. This approach should focus on both liver disease management and cardiometabolic risk factors. This Review examines the link between metabolic dysfunction and liver dysfunction and extrahepatic disease outcomes, the diverse mechanisms in MASLD due to metabolic dysfunction, and a comprehensive, personalized management model for patients with MASLD.</p>","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"24 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroimmune interactions influence pancreatic glucagon secretion in fasting mice
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-02-12 DOI: 10.1038/s41575-025-01049-9
Jordan Hindson
{"title":"Neuroimmune interactions influence pancreatic glucagon secretion in fasting mice","authors":"Jordan Hindson","doi":"10.1038/s41575-025-01049-9","DOIUrl":"10.1038/s41575-025-01049-9","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"22 3","pages":"152-152"},"PeriodicalIF":45.9,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Understanding the therapeutic toolkit for inflammatory bowel disease
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-02-10 DOI: 10.1038/s41575-025-01047-x
Sophie Vieujean, Vipul Jairath, Laurent Peyrin-Biroulet, Marla Dubinsky, Marietta Iacucci, Fernando Magro, Silvio Danese
{"title":"Author Correction: Understanding the therapeutic toolkit for inflammatory bowel disease","authors":"Sophie Vieujean, Vipul Jairath, Laurent Peyrin-Biroulet, Marla Dubinsky, Marietta Iacucci, Fernando Magro, Silvio Danese","doi":"10.1038/s41575-025-01047-x","DOIUrl":"https://doi.org/10.1038/s41575-025-01047-x","url":null,"abstract":"<p>Correction to: <i>Nature Reviews Gastroenterology &amp; Hepatology</i> https://doi.org/10.1038/s41575-024-01035-7, published online 31 January 2025.</p>","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"23 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bridging the gap between science and survival
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-02-07 DOI: 10.1038/s41575-025-01044-0
Ahsen Ustaoglu
{"title":"Bridging the gap between science and survival","authors":"Ahsen Ustaoglu","doi":"10.1038/s41575-025-01044-0","DOIUrl":"10.1038/s41575-025-01044-0","url":null,"abstract":"A scientist’s personal journey through breast cancer underscores the urgency for greater empathy in research and healthcare, a patient-centred approach to data dissemination, and more comprehensive, streamlined support for early-career researchers navigating health crises.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"22 4","pages":"223-224"},"PeriodicalIF":45.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143258069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New potent HBV replication inhibitors for the management of chronic hepatitis B are needed
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-02-05 DOI: 10.1038/s41575-025-01037-z
Timothy M. Block, Ju-Tao Guo, Fabien Zoulim, Charles M. Rice, Chloe L. Thio, William M. Schneider, Harvey J. Alter, Ira M. Jacobson, Robert G. Gish, Peter D. Block, Mark Sulkowski, Jordan J. Feld, Chari A. Cohen
{"title":"New potent HBV replication inhibitors for the management of chronic hepatitis B are needed","authors":"Timothy M. Block,&nbsp;Ju-Tao Guo,&nbsp;Fabien Zoulim,&nbsp;Charles M. Rice,&nbsp;Chloe L. Thio,&nbsp;William M. Schneider,&nbsp;Harvey J. Alter,&nbsp;Ira M. Jacobson,&nbsp;Robert G. Gish,&nbsp;Peter D. Block,&nbsp;Mark Sulkowski,&nbsp;Jordan J. Feld,&nbsp;Chari A. Cohen","doi":"10.1038/s41575-025-01037-z","DOIUrl":"10.1038/s41575-025-01037-z","url":null,"abstract":"With several drugs in use that inhibit the hepatitis B virus polymerases (nucleos(t)ide analogues (or NUCs)), some argue that new direct-acting antiviral drugs, and new NUCs in particular, are not necessary. Here, we make the counter-argument that additional direct-acting antiviral drugs that can potently suppress hepatitis B virus replication, ideally via distinct mechanisms, are still needed and can provide additional therapeutic benefits.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"22 3","pages":"150-151"},"PeriodicalIF":45.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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