Nature Reviews Gastroenterology &Hepatology最新文献_第2页

Liver diseases and hepatocellular carcinoma in the Asia-Pacific region: burden, trends, challenges and future directions 亚太地区的肝病和肝细胞癌：负担、趋势、挑战和未来方向

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-08-15 DOI: 10.1038/s41575-024-00967-4

Lung-Yi Mak, Ken Liu, Sakkarin Chirapongsathorn, Kuo Chao Yew, Nobuharu Tamaki, Ruveena Bhavani Rajaram, Mara Teresa Panlilio, Rashid Lui, Hye Won Lee, Jimmy Che-To Lai, Anand V. Kulkarni, Madhumita Premkumar, Cosmas Rinaldi Adithya Lesmana, Yao Chun Hsu, Daniel Q. Huang

{"title":"Liver diseases and hepatocellular carcinoma in the Asia-Pacific region: burden, trends, challenges and future directions","authors":"Lung-Yi Mak, Ken Liu, Sakkarin Chirapongsathorn, Kuo Chao Yew, Nobuharu Tamaki, Ruveena Bhavani Rajaram, Mara Teresa Panlilio, Rashid Lui, Hye Won Lee, Jimmy Che-To Lai, Anand V. Kulkarni, Madhumita Premkumar, Cosmas Rinaldi Adithya Lesmana, Yao Chun Hsu, Daniel Q. Huang","doi":"10.1038/s41575-024-00967-4","DOIUrl":"https://doi.org/10.1038/s41575-024-00967-4","url":null,"abstract":"Globally, nearly half of deaths from cirrhosis and chronic liver diseases (CLD) and three-quarters of deaths from hepatocellular carcinoma (HCC) occur in the Asia-Pacific region. Chronic hepatitis B is responsible for the vast majority of liver-related deaths in the region. Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common form of CLD, affecting an estimated 30% of the adult population. Compared with people of European descent, people from the Asia-Pacific region carry more genetic variants associated with MASLD and its progression. Alcohol is a fast-growing cause of CLD and HCC in Asia as a result of the rising per-capita consumption of alcohol. Drug-induced liver injury is under-recognized and probably has a high prevalence in this region. The epidemiological and outcome data of acute-on-chronic liver failure are heterogeneous, and non-unified definitions across regions contribute to this heterogeneity. CLDs are severely underdiagnosed, and effective treatments and vaccinations are underutilized. In this Review, we highlight trends in the burden of CLD and HCC in the Asia-Pacific region and discuss the rapidly changing aetiologies of liver disease. We examine the multiple gaps in the care cascade and propose mitigating strategies and future directions.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":65.1,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141986364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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EPC 2024 EPC 2024。

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-08-12 DOI: 10.1038/s41575-024-00979-0

Jordan Hindson

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Cellular and molecular basis of proximal small intestine disorders 近端小肠疾病的细胞和分子基础

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-08-08 DOI: 10.1038/s41575-024-00962-9

Tania Bildstein, Fabienne Charbit-Henrion, Aline Azabdaftari, Nadine Cerf-Bensussan, Holm H. Uhlig

{"title":"Cellular and molecular basis of proximal small intestine disorders","authors":"Tania Bildstein, Fabienne Charbit-Henrion, Aline Azabdaftari, Nadine Cerf-Bensussan, Holm H. Uhlig","doi":"10.1038/s41575-024-00962-9","DOIUrl":"https://doi.org/10.1038/s41575-024-00962-9","url":null,"abstract":"The proximal part of the small intestine, including duodenum and jejunum, is not only dedicated to nutrient digestion and absorption but is also a highly regulated immune site exposed to environmental factors. Host-protective responses against pathogens and tolerance to food antigens are essential functions in the small intestine. The cellular ecology and molecular pathways to maintain those functions are complex. Maladaptation is highlighted by common immune-mediated diseases such as coeliac disease, environmental enteric dysfunction or duodenal Crohn’s disease. An expanding spectrum of more than 100 rare monogenic disorders inform on causative molecular mechanisms of nutrient absorption, epithelial homeostasis and barrier function, as well as inflammatory immune responses and immune regulation. Here, after summarizing the architectural and cellular traits that underlie the functions of the proximal intestine, we discuss how the integration of tissue immunopathology and molecular mechanisms can contribute towards our understanding of disease and guide diagnosis. We propose an integrated mechanism-based taxonomy and discuss the latest experimental approaches to gain new mechanistic insight into these disorders with large disease burden worldwide as well as implications for therapeutic interventions.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":65.1,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141904647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Risankizumab versus ustekinumab for Crohn’s disease: a phase IIIb study 利桑珠单抗与乌司他单抗治疗克罗恩病：IIIb 期研究

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-08-05 DOI: 10.1038/s41575-024-00973-6

Eleni Kotsiliti

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EASL Congress 2024 2024 年 EASL 大会

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-08-05 DOI: 10.1038/s41575-024-00971-8

Eleni Kotsiliti

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Metastatic pancreatic cancer and the liver 转移性胰腺癌和肝脏

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-08-05 DOI: 10.1038/s41575-024-00972-7

Eleni Kotsiliti

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Author Correction: A roadmap for clinical trials in MASH-related compensated cirrhosis. 作者更正：MASH 相关代偿性肝硬化临床试验路线图。

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-08-05 DOI: 10.1038/s41575-024-00976-3

Juan M Pericàs, Quentin M Anstee, Salvador Augustin, Ramón Bataller, Annalisa Berzigotti, Andreea Ciudin, Sven Francque, Juan G Abraldes, Virginia Hernández-Gea, Mònica Pons, Thomas Reiberger, Ian A Rowe, Peter Rydqvist, Elmer Schabel, Frank Tacke, Emmanuel A Tsochatzis, Joan Genescà

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Food inequity and insecurity and MASLD: burden, challenges, and interventions 粮食不公平和不安全与 MASLD：负担、挑战和干预措施

IF 65.1 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-29 DOI: 10.1038/s41575-024-00959-4

Shira Zelber-Sagi, Patrizia Carrieri, Juan M. Pericàs, Dana Ivancovsky-Wajcman, Zobair M. Younossi, Jeffrey V. Lazarus

{"title":"Food inequity and insecurity and MASLD: burden, challenges, and interventions","authors":"Shira Zelber-Sagi, Patrizia Carrieri, Juan M. Pericàs, Dana Ivancovsky-Wajcman, Zobair M. Younossi, Jeffrey V. Lazarus","doi":"10.1038/s41575-024-00959-4","DOIUrl":"https://doi.org/10.1038/s41575-024-00959-4","url":null,"abstract":"Liver disease prevalence, severity, outcomes and hepatic risk factors (for example, unhealthy diet) are heavily affected by socioeconomic status and food insecurity. Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent liver disease globally and is likely to co-occur with other liver diseases associated with food insecurity. Though weight reduction and adopting a healthy diet can reverse the course of MASLD, gaps between recommendations and practice transcend individual responsibility and preference. Broader sociocultural determinants of food choices (social nutrition) include food insecurity, community and social norms and the local environment, including commercial pressures that target people experiencing poverty, ethnic minorities and children. Food insecurity is a barrier to a healthy diet, as a low-quality diet is often less expensive than a healthy one. Consequently, food insecurity is an ‘upstream’ risk factor for MASLD, advanced fibrosis and greater all-cause mortality among patients with liver disease. Intervening on food insecurity at four major levels (environment, policy, community and health care) can reduce the burden of liver disease, thereby reducing social and health inequities. In this Review, we report on the current research in the field, the need for implementing proven interventions, and the role liver specialists can have.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":65.1,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141791009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Mother-to-child transmission of hepatitis B: current status and the road forward 乙型肝炎的母婴传播：现状与未来之路

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-28 DOI: 10.1038/s41575-024-00956-7

Yvonne A. Nartey, Ansumana S. Bockarie

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Viral hepatitis elimination — time to act 消除病毒性肝炎--是时候采取行动了

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-28 DOI: 10.1038/s41575-024-00963-8

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