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Nature Reviews Gastroenterology &Hepatology最新文献

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Moving towards more personalized approaches in locally advanced and metastatic colorectal cancer 在局部晚期和转移性结直肠癌的治疗中采用更加个性化的方法
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-11-28 DOI: 10.1038/s41575-024-01025-9
Chelsie K. Sievers, Cathy Eng
{"title":"Moving towards more personalized approaches in locally advanced and metastatic colorectal cancer","authors":"Chelsie K. Sievers, Cathy Eng","doi":"10.1038/s41575-024-01025-9","DOIUrl":"https://doi.org/10.1038/s41575-024-01025-9","url":null,"abstract":"Colorectal cancer remains a challenging heterogeneous disease with substantial morbidity and mortality. However, progressive advances over the past year have led to marked improvements and overcome challenges previously considered insurmountable. Here, we review key clinical trials in colorectal cancer in 2024, leading to personalized approaches in locally advanced and metastatic disease.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"37 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ins and outs of tumour resistance 肿瘤抗药性的来龙去脉
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-11-22 DOI: 10.1038/s41575-024-01027-7
Michael Attwaters
{"title":"The ins and outs of tumour resistance","authors":"Michael Attwaters","doi":"10.1038/s41575-024-01027-7","DOIUrl":"10.1038/s41575-024-01027-7","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"22 1","pages":"7-7"},"PeriodicalIF":45.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The gut–brain axis and pain signalling mechanisms in the gastrointestinal tract 胃肠道中的肠脑轴和疼痛信号机制
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-11-22 DOI: 10.1038/s41575-024-01017-9
Kimberly A. Meerschaert, Isaac M. Chiu
{"title":"The gut–brain axis and pain signalling mechanisms in the gastrointestinal tract","authors":"Kimberly A. Meerschaert, Isaac M. Chiu","doi":"10.1038/s41575-024-01017-9","DOIUrl":"https://doi.org/10.1038/s41575-024-01017-9","url":null,"abstract":"<p>Visceral pain is a major clinical problem and one of the most common reasons patients with gastrointestinal disorders seek medical help. Peripheral sensory neurons that innervate the gut can detect noxious stimuli and send signals to the central nervous system that are perceived as pain. There is a bidirectional communication network between the gastrointestinal tract and the nervous system that mediates pain through the gut–brain axis. Sensory neurons detect mechanical and chemical stimuli within the intestinal tissues, and receive signals from immune cells, epithelial cells and the gut microbiota, which results in peripheral sensitization and visceral pain. This Review focuses on molecular communication between these non-neuronal cell types and neurons in visceral pain. These bidirectional interactions can be dysregulated during gastrointestinal diseases to exacerbate visceral pain. We outline the anatomical pathways involved in pain processing in the gut and how cell–cell communication is integrated into this gut–brain axis. Understanding how bidirectional communication between the gut and nervous system is altered during disease could provide new therapeutic targets for treating visceral pain.</p>","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"15 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-canonical metastatic colorectal cancer 非典型转移性结直肠癌
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-11-21 DOI: 10.1038/s41575-024-01026-8
Eleni Kotsiliti
{"title":"Non-canonical metastatic colorectal cancer","authors":"Eleni Kotsiliti","doi":"10.1038/s41575-024-01026-8","DOIUrl":"10.1038/s41575-024-01026-8","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"22 1","pages":"7-7"},"PeriodicalIF":45.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-density lipoprotein lipidome: a neglected source of hepatic lipids 高密度脂蛋白脂质体：被忽视的肝脏脂质来源
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-11-18 DOI: 10.1038/s41575-024-01020-0
Gabriele Mocciaro
{"title":"High-density lipoprotein lipidome: a neglected source of hepatic lipids","authors":"Gabriele Mocciaro","doi":"10.1038/s41575-024-01020-0","DOIUrl":"10.1038/s41575-024-01020-0","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"22 1","pages":"8-8"},"PeriodicalIF":45.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transforming the landscape of liver cancer detection and care 改变肝癌检测和护理的格局
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-11-18 DOI: 10.1038/s41575-024-01018-8
Terry Cheuk-Fung Yip, Grace Lai-Hung Wong
{"title":"Transforming the landscape of liver cancer detection and care","authors":"Terry Cheuk-Fung Yip, Grace Lai-Hung Wong","doi":"10.1038/s41575-024-01018-8","DOIUrl":"https://doi.org/10.1038/s41575-024-01018-8","url":null,"abstract":"In 2024, important studies highlighted the ongoing global battle against liver cancer, a deadly yet common cancer. Despite advances in treatments, obstacles persist in early detection and equity in healthcare access. The journey towards improving patient outcomes remains bumpy. Gaining insights from failures is critical for effectively tackling this persistent health threat.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"60 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142665368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unlocking CD8+ T cell potential in chronic hepatitis B virus infection. 释放 CD8+ T 细胞在慢性乙型肝炎病毒感染中的潜能。
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-11-18 DOI: 10.1038/s41575-024-01015-x
Valeria Fumagalli, Matteo Iannacone
{"title":"Unlocking CD8<sup>+</sup> T cell potential in chronic hepatitis B virus infection.","authors":"Valeria Fumagalli, Matteo Iannacone","doi":"10.1038/s41575-024-01015-x","DOIUrl":"https://doi.org/10.1038/s41575-024-01015-x","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":" ","pages":""},"PeriodicalIF":45.9,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new treatment and updated clinical practice guidelines for MASLD MASLD 的新疗法和最新临床实践指南
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-11-11 DOI: 10.1038/s41575-024-01014-y
Elizabeth E. Powell
{"title":"A new treatment and updated clinical practice guidelines for MASLD","authors":"Elizabeth E. Powell","doi":"10.1038/s41575-024-01014-y","DOIUrl":"https://doi.org/10.1038/s41575-024-01014-y","url":null,"abstract":"The year 2024 was momentous for metabolic dysfunction-associated steatotic liver disease (MASLD): the approval of the first medication for treatment of at-risk metabolic dysfunction-associated steatohepatitis, updated guidelines on the screening, diagnosis and treatment of MASLD, and liver stiffness measurement as an important surrogate marker for liver-related outcomes in MASLD.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"18 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic health across the ages: how microbiota members support our well-being 各年龄段的代谢健康：微生物群成员如何支持我们的健康
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-11-11 DOI: 10.1038/s41575-024-01004-0
Carolina Tropini
{"title":"Metabolic health across the ages: how microbiota members support our well-being","authors":"Carolina Tropini","doi":"10.1038/s41575-024-01004-0","DOIUrl":"https://doi.org/10.1038/s41575-024-01004-0","url":null,"abstract":"The microbiota is critical for metabolic health. Studies published in 2024 have revealed mechanisms by which key bacterial and micro-eukaryotic organisms optimize energy production in our body and ensure efficient metabolic function.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"18 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142596981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transport functions of intestinal lymphatic vessels 肠道淋巴管的运输功能
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-11-04 DOI: 10.1038/s41575-024-00996-z
Patrick Tso, Jeremiah Bernier-Latmani, Tatiana V. Petrova, Min Liu
{"title":"Transport functions of intestinal lymphatic vessels","authors":"Patrick Tso, Jeremiah Bernier-Latmani, Tatiana V. Petrova, Min Liu","doi":"10.1038/s41575-024-00996-z","DOIUrl":"https://doi.org/10.1038/s41575-024-00996-z","url":null,"abstract":"<p>Lymphatic vessels are crucial for fluid absorption and the transport of peripheral immune cells to lymph nodes. However, in the small intestine, the lymphatic fluid is rich in diet-derived lipids incorporated into chylomicrons and gut-specific immune cells. Thus, intestinal lymphatic vessels have evolved to handle these unique cargoes and are critical for systemic dietary lipid delivery and metabolism. This Review covers mechanisms of lipid absorption from epithelial cells to the lymphatics as well as unique features of the gut microenvironment that affect these functions. Moreover, we discuss details of the intestinal lymphatics in gut immune cell trafficking and insights into the role of inter-organ communication. Lastly, we highlight the particularities of fat absorption that can be harnessed for efficient lipid-soluble drug distribution for novel therapies, including the ability of chylomicron-associated drugs to bypass first-pass liver metabolism for systemic delivery. In all, this Review will help to promote an understanding of intestinal lymphatic–systemic interactions to guide future research directions.</p>","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"65 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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