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Author Correction: Μetabolic dysfunction-associated steatotic liver disease: a condition of heterogeneous metabolic risk factors, mechanisms and comorbidities requiring holistic treatment
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-03-07 DOI: 10.1038/s41575-025-01056-w
Christopher D. Byrne, Angelo Armandi, Vanessa Pellegrinelli, Antonio Vidal-Puig, Elisabetta Bugianesi
{"title":"Author Correction: Μetabolic dysfunction-associated steatotic liver disease: a condition of heterogeneous metabolic risk factors, mechanisms and comorbidities requiring holistic treatment","authors":"Christopher D. Byrne, Angelo Armandi, Vanessa Pellegrinelli, Antonio Vidal-Puig, Elisabetta Bugianesi","doi":"10.1038/s41575-025-01056-w","DOIUrl":"https://doi.org/10.1038/s41575-025-01056-w","url":null,"abstract":"<p>Correction to: <i>Nature Reviews Gastroenterology &amp; Hepatology</i> https://doi.org/10.1038/s41575-025-01045-z, published online 17 February 2025.</p>","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"7 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estimating dietary intake from human stool DNA
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-03-07 DOI: 10.1038/s41575-025-01054-y
Katrina Ray
{"title":"Estimating dietary intake from human stool DNA","authors":"Katrina Ray","doi":"10.1038/s41575-025-01054-y","DOIUrl":"10.1038/s41575-025-01054-y","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"22 4","pages":"225-225"},"PeriodicalIF":45.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RNA vaccine induces long-lived anti-tumour T cells in pancreatic cancer
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-03-07 DOI: 10.1038/s41575-025-01055-x
Katrina Ray
{"title":"RNA vaccine induces long-lived anti-tumour T cells in pancreatic cancer","authors":"Katrina Ray","doi":"10.1038/s41575-025-01055-x","DOIUrl":"10.1038/s41575-025-01055-x","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"22 4","pages":"225-225"},"PeriodicalIF":45.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ECCO’25
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-03-06 DOI: 10.1038/s41575-025-01053-z
Eleni Kotsiliti
{"title":"ECCO’25","authors":"Eleni Kotsiliti","doi":"10.1038/s41575-025-01053-z","DOIUrl":"10.1038/s41575-025-01053-z","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"22 4","pages":"225-225"},"PeriodicalIF":45.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing an adaptive platform trial for evaluation of medical treatments for Crohn’s disease
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-03-05 DOI: 10.1038/s41575-025-01052-0
Nurulamin M. Noor, Shellie J. Radford, Babak Choodari-Oskooei, Morris Gordon, Ailsa L. Hart, Trish Hepburn, Ed Juszczak, James O. Lindsay, Nicholas A. Kennedy, Mahesh K. B. Parmar, Vipul Jairath, Gordon W. Moran
{"title":"Developing an adaptive platform trial for evaluation of medical treatments for Crohn’s disease","authors":"Nurulamin M. Noor, Shellie J. Radford, Babak Choodari-Oskooei, Morris Gordon, Ailsa L. Hart, Trish Hepburn, Ed Juszczak, James O. Lindsay, Nicholas A. Kennedy, Mahesh K. B. Parmar, Vipul Jairath, Gordon W. Moran","doi":"10.1038/s41575-025-01052-0","DOIUrl":"https://doi.org/10.1038/s41575-025-01052-0","url":null,"abstract":"There is emerging interest in adaptive platform trials for inflammatory bowel disease. In this Comment, we present the results of a workshop that was convened to consider the opportunities and challenges of developing a platform trial in Crohn’s disease.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"29 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Consensus Statement on establishing causality, therapeutic applications and the use of preclinical models in microbiome research
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-03-03 DOI: 10.1038/s41575-025-01041-3
Amira Metwaly, Aicha Kriaa, Zahra Hassani, Federica Carraturo, Celine Druart, Kaline Arnauts, Paul Wilmes, Jens Walter, Stephan Rosshart, Mahesh S. Desai, Joel Dore, Hervé M. Blottiere, Emmanuelle Maguin, Dirk Haller
{"title":"A Consensus Statement on establishing causality, therapeutic applications and the use of preclinical models in microbiome research","authors":"Amira Metwaly, Aicha Kriaa, Zahra Hassani, Federica Carraturo, Celine Druart, Kaline Arnauts, Paul Wilmes, Jens Walter, Stephan Rosshart, Mahesh S. Desai, Joel Dore, Hervé M. Blottiere, Emmanuelle Maguin, Dirk Haller","doi":"10.1038/s41575-025-01041-3","DOIUrl":"https://doi.org/10.1038/s41575-025-01041-3","url":null,"abstract":"<p>The gut microbiome comprises trillions of microorganisms and profoundly influences human health by modulating metabolism, immune responses and neuronal functions. Disruption in gut microbiome composition is implicated in various inflammatory conditions, metabolic disorders and neurodegenerative diseases. However, determining the underlying mechanisms and establishing cause and effect is extremely difficult. Preclinical models offer crucial insights into the role of the gut microbiome in diseases and help identify potential therapeutic interventions. The Human Microbiome Action Consortium initiated a Delphi survey to assess the utility of preclinical models, including animal and cell-based models, in elucidating the causal role of the gut microbiome in these diseases. The Delphi survey aimed to address the complexity of selecting appropriate preclinical models to investigate disease causality and to study host–microbiome interactions effectively. We adopted a structured approach encompassing a literature review, expert workshops and the Delphi questionnaire to gather insights from a diverse range of stakeholders. Experts were requested to evaluate the strengths, limitations, and suitability of these models in addressing the causal relationship between the gut microbiome and disease pathogenesis. The resulting consensus statements and recommendations provide valuable insights for selecting preclinical models in future studies of gut microbiome-related diseases.</p>","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"130 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI-enabled ‘endo-histo-omics’: breaking down intestinal barriers in IBD 人工智能 "肠组织组学"：打破肠道疾病的肠道屏障
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-03-03 DOI: 10.1038/s41575-025-01051-1
Marietta Iacucci, Yasuharu Maeda, Giovanni Santacroce, Subrata Ghosh
{"title":"AI-enabled ‘endo-histo-omics’: breaking down intestinal barriers in IBD","authors":"Marietta Iacucci, Yasuharu Maeda, Giovanni Santacroce, Subrata Ghosh","doi":"10.1038/s41575-025-01051-1","DOIUrl":"https://doi.org/10.1038/s41575-025-01051-1","url":null,"abstract":"The AI-driven ‘endo-histo-omics’ approach integrates clinical, endoscopic, histological and molecular data to improve management of inflammatory bowel disease. This strategy enables precise patient stratification and outcome prediction, paving the way for advanced intestinal barrier assessment and restoration, thereby driving progress in personalized care.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"195 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reframing obesity and MASLD
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-02-28 DOI: 10.1038/s41575-025-01046-y
{"title":"Reframing obesity and MASLD","authors":"","doi":"10.1038/s41575-025-01046-y","DOIUrl":"10.1038/s41575-025-01046-y","url":null,"abstract":"As the burden of obesity and metabolic dysfunction-associated steatotic liver disease increases, the focus is shifting to the wide spectrum of disease, more accurate diagnostic criteria and the systems that influence our health to advance care.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"22 3","pages":"147-147"},"PeriodicalIF":45.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41575-025-01046-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clusters of metabolic dysfunction-associated steatotic liver disease for precision medicine
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-02-26 DOI: 10.1038/s41575-025-01048-w
Norbert Stefan, Giovanni Targher
{"title":"Clusters of metabolic dysfunction-associated steatotic liver disease for precision medicine","authors":"Norbert Stefan,&nbsp;Giovanni Targher","doi":"10.1038/s41575-025-01048-w","DOIUrl":"10.1038/s41575-025-01048-w","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous disease regarding its pathophysiology and clinical outcomes. Two novel studies suggest that different clusters of people with MASLD exist, explaining part of this heterogeneity. These findings and future research applying data dimensionality reduction approaches might be beneficial for implementing precision medicine in MASLD.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"22 4","pages":"226-227"},"PeriodicalIF":45.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Helicobacter pylori, microbiota and gastric cancer — principles of microorganism-driven carcinogenesis
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-02-26 DOI: 10.1038/s41575-025-01042-2
Jonas Wizenty, Michael Sigal
{"title":"Helicobacter pylori, microbiota and gastric cancer — principles of microorganism-driven carcinogenesis","authors":"Jonas Wizenty, Michael Sigal","doi":"10.1038/s41575-025-01042-2","DOIUrl":"https://doi.org/10.1038/s41575-025-01042-2","url":null,"abstract":"<p>The demonstration that <i>Helicobacter pylori</i> is a pathogenic bacterium with marked carcinogenic potential has paved the way for new preventive approaches for gastric cancer. Although decades of research have uncovered complex interactions of <i>H. pylori</i> with epithelial cells, current insights have refined our view on <i>H. pylori</i>-associated carcinogenesis. Specifically, the cell-type-specific effects on gastric stem and progenitor cells deep in gastric glands provide a new view on the ability of the bacteria to colonize long-term, manipulate host responses and promote gastric pathology. Furthermore, new, large-scale epidemiological data have shed light on factors that determine why only a subset of carriers progress to gastric cancer. Currently, technological advances have brought yet another revelation: <i>H. pylori</i> is far from the only microorganism able to colonize the stomach. Instead, the stomach is colonized by a diverse gastric microbiota, and there is emerging evidence for the occurrence and pathological effect of dysbiosis resulting from an aberrant interplay between <i>H. pylori</i> and the gastric mucosa. With the weight of this evidence mounting, here we consider how the lessons learned from <i>H. pylori</i> research inform and synergize with this emerging field to bring a more comprehensive understanding of the role of microbes in gastric carcinogenesis.</p>","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"22 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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