感觉神经元-胃癌回路

IF 51 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-04-04 DOI:10.1038/s41575-025-01066-8

Eleni Kotsiliti

引用次数: 0

摘要

发表在《自然》杂志上的一项新研究探讨了感觉神经在胃癌中的作用。该研究的通讯作者Timothy Wang说：“颅外实体瘤中的癌细胞与感觉神经系统形成了一个电路。”通过使用多种胃癌小鼠模型，研究人员发现，表达降钙素基因相关肽（CGRP）的感觉神经在胃肿瘤细胞周围形成了一个神经网络。体内和体外敲除实验表明，CGRP+神经扩张依赖于NGF-TRK信号，胃细胞优先吸引CGRP+肽能伤害性神经元。

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来源期刊

Nature Reviews Gastroenterology &Hepatology 医学-胃肠肝病学

CiteScore

52.30

自引率

0.60%

发文量

147

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.