{"title":"Incorporating genetic variations in alcohol-associated liver disease trials for East Asian populations","authors":"Bossng Kang","doi":"10.1038/s41575-025-01060-0","DOIUrl":null,"url":null,"abstract":"<p>I read with great interest the article by Lee et al. (Lee, B. P. et al. Designing clinical trials to address alcohol use and alcohol-associated liver disease: an expert panel Consensus Statement. <i>Nat. Rev. Gastroenterol. Hepatol</i>. <b>21</b>, 626–645 (2024))<sup>1</sup>. In their Consensus Statement<sup>1</sup>, the authors are to be commended for their comprehensive framework, which integrates methodologies from alcohol use disorder and alcohol-associated liver disease (ALD) research to enhance the quality and efficacy of clinical trials. This effort represents a major step towards addressing the dual challenges of alcohol use and liver disease. However, further refinement is warranted regarding the application of heavy drinking thresholds, particularly in populations with unique genetic predispositions such as East Asian individuals, a population in which aldehyde dehydrogenase 2 (<i>ALDH2</i>) polymorphisms are highly prevalent<sup>2,3</sup>.</p>","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"3 1","pages":""},"PeriodicalIF":45.9000,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Gastroenterology &Hepatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41575-025-01060-0","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
我饶有兴趣地阅读了 Lee 等人的文章（Lee, B. P. et al. Designing clinical trials to address alcohol use and alcohol-associated liver disease: an expert panel Consensus Statement.Nat.Rev. Gastroenterol.Hepatol.21, 626-645 (2024))1.在《共识声明》1 中，作者们提出的综合框架值得称赞，该框架整合了酒精使用障碍和酒精相关肝病 (ALD) 研究的方法，以提高临床试验的质量和疗效。这一努力是应对酒精使用和肝病双重挑战的重要一步。然而，重度饮酒阈值的应用还需要进一步完善，尤其是在东亚人等具有独特遗传倾向的人群中，因为东亚人中醛脱氢酶 2 (ALDH2) 多态性非常普遍2,3。
Incorporating genetic variations in alcohol-associated liver disease trials for East Asian populations
I read with great interest the article by Lee et al. (Lee, B. P. et al. Designing clinical trials to address alcohol use and alcohol-associated liver disease: an expert panel Consensus Statement. Nat. Rev. Gastroenterol. Hepatol. 21, 626–645 (2024))1. In their Consensus Statement1, the authors are to be commended for their comprehensive framework, which integrates methodologies from alcohol use disorder and alcohol-associated liver disease (ALD) research to enhance the quality and efficacy of clinical trials. This effort represents a major step towards addressing the dual challenges of alcohol use and liver disease. However, further refinement is warranted regarding the application of heavy drinking thresholds, particularly in populations with unique genetic predispositions such as East Asian individuals, a population in which aldehyde dehydrogenase 2 (ALDH2) polymorphisms are highly prevalent2,3.
期刊介绍：
Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication.
The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information.
Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.
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