Nature Reviews Gastroenterology &Hepatology最新文献_第7页

Risankizumab versus ustekinumab for Crohn’s disease: a phase IIIb study 利桑珠单抗与乌司他单抗治疗克罗恩病：IIIb 期研究

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-08-05 DOI: 10.1038/s41575-024-00973-6

Eleni Kotsiliti

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EASL Congress 2024 2024 年 EASL 大会

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-08-05 DOI: 10.1038/s41575-024-00971-8

Eleni Kotsiliti

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Metastatic pancreatic cancer and the liver 转移性胰腺癌和肝脏

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-08-05 DOI: 10.1038/s41575-024-00972-7

Eleni Kotsiliti

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Author Correction: A roadmap for clinical trials in MASH-related compensated cirrhosis 作者更正：MASH 相关代偿性肝硬化临床试验路线图。

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-08-05 DOI: 10.1038/s41575-024-00976-3

Juan M. Pericàs, Quentin M. Anstee, Salvador Augustin, Ramón Bataller, Annalisa Berzigotti, Andreea Ciudin, Sven Francque, Juan G. Abraldes, Virginia Hernández-Gea, Mònica Pons, Thomas Reiberger, Ian A. Rowe, Peter Rydqvist, Elmer Schabel, Frank Tacke, Emmanuel A. Tsochatzis, Joan Genescà

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Food inequity and insecurity and MASLD: burden, challenges, and interventions 粮食不公平和不安全与 MASLD：负担、挑战和干预措施

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-29 DOI: 10.1038/s41575-024-00959-4

Shira Zelber-Sagi, Patrizia Carrieri, Juan M. Pericàs, Dana Ivancovsky-Wajcman, Zobair M. Younossi, Jeffrey V. Lazarus

{"title":"Food inequity and insecurity and MASLD: burden, challenges, and interventions","authors":"Shira Zelber-Sagi, Patrizia Carrieri, Juan M. Pericàs, Dana Ivancovsky-Wajcman, Zobair M. Younossi, Jeffrey V. Lazarus","doi":"10.1038/s41575-024-00959-4","DOIUrl":"10.1038/s41575-024-00959-4","url":null,"abstract":"Liver disease prevalence, severity, outcomes and hepatic risk factors (for example, unhealthy diet) are heavily affected by socioeconomic status and food insecurity. Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent liver disease globally and is likely to co-occur with other liver diseases associated with food insecurity. Though weight reduction and adopting a healthy diet can reverse the course of MASLD, gaps between recommendations and practice transcend individual responsibility and preference. Broader sociocultural determinants of food choices (social nutrition) include food insecurity, community and social norms and the local environment, including commercial pressures that target people experiencing poverty, ethnic minorities and children. Food insecurity is a barrier to a healthy diet, as a low-quality diet is often less expensive than a healthy one. Consequently, food insecurity is an ‘upstream’ risk factor for MASLD, advanced fibrosis and greater all-cause mortality among patients with liver disease. Intervening on food insecurity at four major levels (environment, policy, community and health care) can reduce the burden of liver disease, thereby reducing social and health inequities. In this Review, we report on the current research in the field, the need for implementing proven interventions, and the role liver specialists can have. Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is increasing worldwide, and a crucial risk factor is food insecurity. This Review provides an extensive overview of food insecurity in the context of MASLD and discusses potential policies and procedures as interventions.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 10","pages":"668-686"},"PeriodicalIF":45.9,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41575-024-00959-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141791009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Mother-to-child transmission of hepatitis B: current status and the road forward 乙型肝炎的母婴传播：现状与未来之路

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-28 DOI: 10.1038/s41575-024-00956-7

Yvonne A. Nartey, Ansumana S. Bockarie

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Viral hepatitis elimination — time to act 消除病毒性肝炎--是时候采取行动了

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-28 DOI: 10.1038/s41575-024-00963-8

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Western lifestyle, metaflammation and the cell of origin of colon cancer 西方生活方式、元炎症和结肠癌的起源细胞

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-24 DOI: 10.1038/s41575-024-00964-7

Mathijs P. Verhagen, Mark Schmitt, Riccardo Fodde

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Shifting targets for eosinophilic oesophagitis 嗜酸性粒细胞食管炎治疗目标的转变

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-22 DOI: 10.1038/s41575-024-00969-2

Katrina Ray

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Hepatitis E virus: from innate sensing to adaptive immune responses 戊型肝炎病毒：从先天性感应到适应性免疫反应

IF 45.9 1区医学

Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-07-22 DOI: 10.1038/s41575-024-00950-z

Yannick Brüggemann, Mara Klöhn, Heiner Wedemeyer, Eike Steinmann

{"title":"Hepatitis E virus: from innate sensing to adaptive immune responses","authors":"Yannick Brüggemann, Mara Klöhn, Heiner Wedemeyer, Eike Steinmann","doi":"10.1038/s41575-024-00950-z","DOIUrl":"10.1038/s41575-024-00950-z","url":null,"abstract":"Hepatitis E virus (HEV) infections are a major cause of acute viral hepatitis in humans worldwide. In immunocompetent individuals, the majority of HEV infections remain asymptomatic and lead to spontaneous clearance of the virus, and only a minority of individuals with infection (5–16%) experience symptoms of acute viral hepatitis. However, HEV infections can cause up to 30% mortality in pregnant women, become chronic in immunocompromised patients and cause extrahepatic manifestations. A growing body of evidence suggests that the host immune response to infection with different HEV genotypes is a critical determinant of distinct HEV infection outcomes. In this Review, we summarize key components of the innate and adaptive immune responses to HEV, including the underlying immunological mechanisms of HEV associated with acute and chronic liver failure and interactions between T cell and B cell responses. In addition, we discuss the current status of vaccines against HEV and raise outstanding questions regarding the immune responses induced by HEV and treatment of the disease, highlighting areas for future investigation. Many aspects of the biology and pathogenesis of hepatitis E virus (HEV) infection remain underexplored. In this Review, Steinmann and colleagues summarize the role of the innate and adaptive immune systems in HEV infection.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 10","pages":"710-725"},"PeriodicalIF":45.9,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141736891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0