Nature Reviews Gastroenterology &Hepatology最新文献

{"title":"Steatotic liver disease in Latin America: current views and perspectives","authors":"Francisco Idalsoaga, Luis Antonio Díaz, Francisco Barrera, Adrian Gadano, Claudia P. Oliveira, Juan Pablo Arab, Marco Arrese","doi":"10.1038/s41575-026-01219-3","DOIUrl":"10.1038/s41575-026-01219-3","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease, alcohol-associated liver disease and metabolic dysfunction and alcohol-related liver disease represent the principal subtypes of steatotic liver disease (SLD), together constituting a rapidly growing global health challenge. Latin America bears a disproportionately high burden of SLD, driven by the convergence of increasing prevalence of obesity and type 2 diabetes, high levels of harmful alcohol consumption, and a high frequency of genetic risk variants, particularly in the gene encoding patatin-like phospholipase domain-containing protein 3 (PNPLA3). These factors interact synergistically to accelerate disease progression, increasing the risk of steatohepatitis, advanced fibrosis, cirrhosis and hepatocellular carcinoma. Despite this substantial burden, the region faces major structural and health-system constraints, including fragmented health-care delivery, limited hepatology capacity, restricted access to diagnostic and therapeutic technologies, and low participation in clinical trials, all of which hinder early detection and the generation of region-specific evidence. This Review summarizes current data on the epidemiology and clinical burden of SLD in Latin America, identifies critical gaps in research and surveillance, and highlights priorities for prevention, harm reduction and health-system strengthening, including the implementation of effective public policies to reduce morbidity and mortality and improve health outcomes in the region. Steatotic liver disease (SLD) burden is rising worldwide, and Latin America is disproportionately affected. This Review provides a detailed summary of SLD epidemiology in the region, identifies gaps in clinical management and research, and provides suggestions to improve health outcomes.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"23 9","pages":"722-736"},"PeriodicalIF":57.5,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive results for daraxonrasib for previously treated metastatic pancreatic cancer","authors":"Katrina Ray","doi":"10.1038/s41575-026-01222-8","DOIUrl":"10.1038/s41575-026-01222-8","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"23 7","pages":"525-525"},"PeriodicalIF":57.5,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary perturbation and microbial adaptation in the gut","authors":"Yancong Zhang","doi":"10.1038/s41575-026-01220-w","DOIUrl":"10.1038/s41575-026-01220-w","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"23 8","pages":"607-607"},"PeriodicalIF":57.5,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148226681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"European Congress on Obesity 2026","authors":"Eleni Kotsiliti","doi":"10.1038/s41575-026-01221-9","DOIUrl":"10.1038/s41575-026-01221-9","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"23 7","pages":"525-525"},"PeriodicalIF":57.5,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148211941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A people-first, systems-oriented approach to liver disease in HIV infection","authors":"Trenton M. White, Giada Sebastiani, Giovanni Guaraldi, Juan M. Pericàs, Maria J. Fuster-Ruizdeapodaca, Jeffrey V. Lazarus","doi":"10.1038/s41575-026-01218-4","DOIUrl":"10.1038/s41575-026-01218-4","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"23 7","pages":"600-601"},"PeriodicalIF":57.5,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148163777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying MASLD patient eligibility for pharmacological therapy: the need to integrate evidence into clinical practice","authors":"Javier Ampuero, Manuel Romero-Gomez","doi":"10.1038/s41575-026-01214-8","DOIUrl":"10.1038/s41575-026-01214-8","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease is a leading cause of chronic liver disease, with rising liver transplantation rates. New therapies such as resmetirom and semaglutide mark a shift in treatment. However, identifying suitable patients remains challenging, requiring integrated approaches combining fibrosis stage, metabolic factors and non-invasive tools in real-world practice.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"23 7","pages":"523-524"},"PeriodicalIF":57.5,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequencing what we eat","authors":"Lawrence A. David, Brenda M. Davy","doi":"10.1038/s41575-026-01215-7","DOIUrl":"10.1038/s41575-026-01215-7","url":null,"abstract":"Dietary assessment commonly relies on asking people what they remember eating. Genomic methods can change this assessment, paralleling how DNA sequencing revolutionized microbiology. By identifying consumed foods directly from stool, these approaches offer an objective, scalable alternative that gastroenterology researchers can begin using today.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"23 8","pages":"604-605"},"PeriodicalIF":57.5,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147974110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digestive Disease Week 2026","authors":"Katrina Ray","doi":"10.1038/s41575-026-01217-5","DOIUrl":"10.1038/s41575-026-01217-5","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"23 7","pages":"525-525"},"PeriodicalIF":57.5,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147974064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision nutrition for the prevention and management of inflammatory bowel disease","authors":"Jie Chen \u0000 (, ), Lintao Dan \u0000 (, ), Judith Wellens, Vipul Jairath, Henit Yanai, Hamed Khalili, Silvio Danese, Laurent Peyrin-Biroulet, Xiaoyan Wang \u0000 (, ), Xue Li \u0000 (, ), Fernando Magro","doi":"10.1038/s41575-026-01213-9","DOIUrl":"10.1038/s41575-026-01213-9","url":null,"abstract":"The rising disease burden of inflammatory bowel disease (IBD) parallels the changing dietary landscape accompanying industrialization, underscoring the growing relevance of nutritional science in disease prevention and management. Precision nutrition has emerged as a promising approach to prevent and manage IBD through tailored dietary recommendations based on multidimensional individual characteristics, including demographics, disease natural history and multiomics traits. In this Review, we investigate the sources of heterogeneity in dietary responses and propose a stepwise framework for precision nutrition: phenotype-based precision nutrition, informed by general phenotypes in clinical and community settings; omics-based precision nutrition, targeting subgroups with shared biological features identified via omics and complementary approaches; and integrated precision nutrition, providing personalized dietary strategies informed by comprehensive, multidimensional phenotypes. Advances in large-scale longitudinal multiomics cohorts, biomarker detection and artificial intelligence are transforming data acquisition and interpretation, thereby facilitating both interventional research and real-world application of precision nutrition. Key considerations for implementing precision nutrition in IBD are discussed. This Review outlines a holistic and translational framework, aiming to advance both research and clinical practice in the prevention and management of IBD. Diet and nutrition have emerged as promising approaches for the prevention and management of inflammatory bowel disease (IBD). This Review outlines a stepwise framework for precision nutrition for IBD, highlighting how dietary recommendations can be tailored to the individual based on a range of characteristics (including demographics and multiomics data) and key considerations for clinical translation.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"23 9","pages":"703-721"},"PeriodicalIF":57.5,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147974178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding development and cellular plasticity in the pancreas in health and disease","authors":"Alejo Torres-Cano, Francesca M. Spagnoli","doi":"10.1038/s41575-026-01211-x","DOIUrl":"10.1038/s41575-026-01211-x","url":null,"abstract":"Pancreatic development is a dynamic process shaped by coordinated interactions between surrounding non-pancreatic tissues and intrinsic transcription factors, integrated through gene regulatory networks. Advances in single-cell genomics and lineage-tracing technologies have substantially expanded our understanding of pancreatic biology, elucidating the ontogeny of pancreatic cells, their diversity and the intercellular interactions that govern them. In this Review, we examine the emergence of pancreatic cell lineages in the embryo through the lens of cellular plasticity, emphasizing how reciprocal interactions with the microenvironment influence lineage decisions. We also draw parallels between developmental and pathological processes, highlighting the dual role of plasticity: enabling lineage specification during development and supporting regenerative responses upon injury or in disease states. A deeper appreciation of the mechanisms underlying pancreatic cell identity and plasticity holds the potential to inform the development of new therapeutic modalities for pancreatic diseases, such as diabetes and pancreatic cancer. Pancreatic development is a dynamic process. This Review discusses the development and cellular plasticity that occurs in the pancreas in health and disease, with insights into early development, endocrine and exocrine lineages and the pancreatic microenvironment.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"23 9","pages":"674-687"},"PeriodicalIF":57.5,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147931529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}