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MASLD: a disease in flux MASLD：变化中的疾病
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-10-02 DOI: 10.1038/s41575-024-00990-5
Alina M. Allen, Juan Pablo Arab, Vincent Wai-Sun Wong
{"title":"MASLD: a disease in flux","authors":"Alina M. Allen, Juan Pablo Arab, Vincent Wai-Sun Wong","doi":"10.1038/s41575-024-00990-5","DOIUrl":"10.1038/s41575-024-00990-5","url":null,"abstract":"To coincide with the 20th anniversary of Nature Reviews Gastroenterology & Hepatology, we asked three experts to reflect on the past, present and future of metabolic dysfunction-associated steatotic liver disease (MASLD) research and clinical management. They comment on how MASLD research and clinical management has changed over the past 20 years, the strengths and limitations of the MASLD field today, and their predictions for progress over the next 20 years. In this Viewpoint, Alina M. Allen, Juan Pablo Arab and Vincent Wai-Sun Wong reflect on the past, present and future of metabolic dysfunction-associated steatotic liver disease (MASLD) research and clinical management.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 11","pages":"747-750"},"PeriodicalIF":45.9,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41575-024-00990-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary and metabolic effects on intestinal stem cells in health and disease 饮食和新陈代谢对健康和疾病中肠干细胞的影响
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-10-02 DOI: 10.1038/s41575-024-00980-7
Jessica E. S. Shay, Ömer H. Yilmaz
{"title":"Dietary and metabolic effects on intestinal stem cells in health and disease","authors":"Jessica E. S. Shay, Ömer H. Yilmaz","doi":"10.1038/s41575-024-00980-7","DOIUrl":"https://doi.org/10.1038/s41575-024-00980-7","url":null,"abstract":"<p>Diet and nutritional metabolites exhibit wide-ranging effects on health and disease partly by altering tissue composition and function. With rapidly rising rates of obesity, there is particular interest in how obesogenic diets influence tissue homeostasis and risk of tumorigenesis; epidemiologically, these diets have a positive correlation with various cancers, including colorectal cancer. The gastrointestinal tract is a highly specialized, continuously renewing tissue with a fundamental role in nutrient uptake and is, in turn, influenced by diet composition and host metabolic state. Intestinal stem cells are found at the base of the intestinal crypt and can generate all mature lineages that comprise the intestinal epithelium and are uniquely influenced by host diet, metabolic by-products and energy dynamics. Similarly, tumour growth and metabolism can also be shaped by nutrient availability and host diet. In this Review, we discuss how different diets and metabolic changes influence intestinal stem cells in homeostatic and pathological conditions, as well as tumorigenesis. We also discuss how dietary changes and composition affect the intestinal epithelium and its surrounding microenvironment.</p>","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"58 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapy affects tumour microenvironment in pancreatic cancer 治疗会影响胰腺癌的肿瘤微环境
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-10-01 DOI: 10.1038/s41575-024-00999-w
Eleni Kotsiliti
{"title":"Therapy affects tumour microenvironment in pancreatic cancer","authors":"Eleni Kotsiliti","doi":"10.1038/s41575-024-00999-w","DOIUrl":"10.1038/s41575-024-00999-w","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 11","pages":"746-746"},"PeriodicalIF":45.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142330385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuft cells in the intestine, immunity and beyond 肠道中的簇细胞、免疫力及其他
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-09-26 DOI: 10.1038/s41575-024-00978-1
Xiaogang Feng  , Pascal Flüchter, Jeshua C. De Tenorio, Christoph Schneider
{"title":"Tuft cells in the intestine, immunity and beyond","authors":"Xiaogang Feng \u0000 ,&nbsp;Pascal Flüchter,&nbsp;Jeshua C. De Tenorio,&nbsp;Christoph Schneider","doi":"10.1038/s41575-024-00978-1","DOIUrl":"10.1038/s41575-024-00978-1","url":null,"abstract":"Tuft cells have gained substantial attention over the past 10 years due to numerous reports linking them with type 2 immunity and microorganism-sensing capacity in many mucosal tissues. This heightened interest is fuelled by their unique ability to produce an array of biological effector molecules, including IL-25, allergy-related eicosanoids, and the neurotransmitter acetylcholine, enabling downstream responses in diverse cell types. Operating through G protein-coupled receptor-mediated signalling pathways reminiscent of type II taste cells in oral taste buds, tuft cells emerge as chemosensory sentinels that integrate luminal conditions, eliciting appropriate responses in immune, epithelial and neuronal populations. How tuft cells promote tissue alterations and adaptation to the variety of stimuli at mucosal surfaces has been explored in multiple studies in the past few years. Since the initial recognition of the role of tuft cells, the discovery of diverse tuft cell effector functions and associated feedback loops have also revealed the complexity of tuft cell biology. Although earlier work largely focused on extraintestinal tissues, novel genetic tools and recent mechanistic studies on intestinal tuft cells established fundamental concepts of tuft cell activation and functions. This Review is an overview of intestinal tuft cells, providing insights into their development, signalling and interaction modules in immunity and other states. Tuft cells have important roles in type 2 immunity and antimicrobial responses in mucosal tissues. This Review provides an overview of intestinal tuft cells, providing insights into their phenotype, function and role in the intestine in immunity and other states.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 12","pages":"852-868"},"PeriodicalIF":45.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142321384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Justice, equity, diversity and inclusion in gastroenterology and hepatology 肠胃病学和肝病学的公正、公平、多样性和包容性
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-09-26 DOI: 10.1038/s41575-024-00985-2
{"title":"Justice, equity, diversity and inclusion in gastroenterology and hepatology","authors":"","doi":"10.1038/s41575-024-00985-2","DOIUrl":"10.1038/s41575-024-00985-2","url":null,"abstract":"Nature Reviews Gastroenterology &amp; Hepatology is launching a new Series on justice, equity, diversity and inclusion in an effort to increase awareness and advance equitable health.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 10","pages":"661-661"},"PeriodicalIF":45.9,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41575-024-00985-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142317206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A resource for the food microbiome and its links with the human microbiome 有关食物微生物群及其与人类微生物群联系的资源。
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-09-20 DOI: 10.1038/s41575-024-00993-2
Katrina Ray
{"title":"A resource for the food microbiome and its links with the human microbiome","authors":"Katrina Ray","doi":"10.1038/s41575-024-00993-2","DOIUrl":"10.1038/s41575-024-00993-2","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 11","pages":"746-746"},"PeriodicalIF":45.9,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disease prevention trials in IBD: feasibility to future outlook. IBD 疾病预防试验：从可行性到未来展望。
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-09-20 DOI: 10.1038/s41575-024-00984-3
Sailish Honap,Nelly Agrinier,Silvio Danese,Laurent Peyrin-Biroulet
{"title":"Disease prevention trials in IBD: feasibility to future outlook.","authors":"Sailish Honap,Nelly Agrinier,Silvio Danese,Laurent Peyrin-Biroulet","doi":"10.1038/s41575-024-00984-3","DOIUrl":"https://doi.org/10.1038/s41575-024-00984-3","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strengthening the foundation of African microbiome research: strategies for standardized data collection 加强非洲微生物组研究的基础：标准化数据收集战略
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-09-19 DOI: 10.1038/s41575-024-00986-1
Soumaya Kouidhi, Ovokeraye H. Oduaran
{"title":"Strengthening the foundation of African microbiome research: strategies for standardized data collection","authors":"Soumaya Kouidhi,&nbsp;Ovokeraye H. Oduaran","doi":"10.1038/s41575-024-00986-1","DOIUrl":"10.1038/s41575-024-00986-1","url":null,"abstract":"The current state of microbiome research in Africa can be leveraged to encourage the development and implementation of standardized processes for data collection and management. In this Comment, we provide some recommendations to enable the research community to fully harness the richness of the microbiome of&nbsp;African populations&nbsp;and potential opportunities therein.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 11","pages":"742-743"},"PeriodicalIF":45.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A greener gastroenterology: challenges and opportunities for an eco-sustainable approach to digestive diseases 更环保的肠胃病学：采用生态可持续方法治疗消化系统疾病的挑战与机遇
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-09-12 DOI: 10.1038/s41575-024-00983-4
Giovanni Cammarota, Gianluca Ianiro
{"title":"A greener gastroenterology: challenges and opportunities for an eco-sustainable approach to digestive diseases","authors":"Giovanni Cammarota,&nbsp;Gianluca Ianiro","doi":"10.1038/s41575-024-00983-4","DOIUrl":"10.1038/s41575-024-00983-4","url":null,"abstract":"Gastroenterology as a specialty can make a substantial contribution to reducing the carbon footprint of the health-care system. Concrete actions are needed to increase awareness, education and evidence-based knowledge on eco-sustainable diagnostic and therapeutic approaches to digestive diseases.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 11","pages":"744-745"},"PeriodicalIF":45.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterizing the genomic landscape of colorectal cancer 描述结直肠癌的基因组特征
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-09-09 DOI: 10.1038/s41575-024-00988-z
Jordan Hindson
{"title":"Characterizing the genomic landscape of colorectal cancer","authors":"Jordan Hindson","doi":"10.1038/s41575-024-00988-z","DOIUrl":"10.1038/s41575-024-00988-z","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 10","pages":"667-667"},"PeriodicalIF":45.9,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142158960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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