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Disease prevention trials in IBD: feasibility to future outlook. IBD 疾病预防试验：从可行性到未来展望。
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-09-20 DOI: 10.1038/s41575-024-00984-3
Sailish Honap,Nelly Agrinier,Silvio Danese,Laurent Peyrin-Biroulet
{"title":"Disease prevention trials in IBD: feasibility to future outlook.","authors":"Sailish Honap,Nelly Agrinier,Silvio Danese,Laurent Peyrin-Biroulet","doi":"10.1038/s41575-024-00984-3","DOIUrl":"https://doi.org/10.1038/s41575-024-00984-3","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":65.1,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A resource for the food microbiome and its links with the human microbiome 有关食物微生物群及其与人类微生物群联系的资源。
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-09-20 DOI: 10.1038/s41575-024-00993-2
Katrina Ray
{"title":"A resource for the food microbiome and its links with the human microbiome","authors":"Katrina Ray","doi":"10.1038/s41575-024-00993-2","DOIUrl":"10.1038/s41575-024-00993-2","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":45.9,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142275221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strengthening the foundation of African microbiome research: strategies for standardized data collection 加强非洲微生物组研究的基础：标准化数据收集战略
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-09-19 DOI: 10.1038/s41575-024-00986-1
Soumaya Kouidhi, Ovokeraye H. Oduaran
{"title":"Strengthening the foundation of African microbiome research: strategies for standardized data collection","authors":"Soumaya Kouidhi, Ovokeraye H. Oduaran","doi":"10.1038/s41575-024-00986-1","DOIUrl":"10.1038/s41575-024-00986-1","url":null,"abstract":"The current state of microbiome research in Africa can be leveraged to encourage the development and implementation of standardized processes for data collection and management. In this Comment, we provide some recommendations to enable the research community to fully harness the richness of the microbiome of African populations and potential opportunities therein.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":45.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142245518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A greener gastroenterology: challenges and opportunities for an eco-sustainable approach to digestive diseases 更环保的肠胃病学：采用生态可持续方法治疗消化系统疾病的挑战与机遇
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-09-12 DOI: 10.1038/s41575-024-00983-4
Giovanni Cammarota, Gianluca Ianiro
{"title":"A greener gastroenterology: challenges and opportunities for an eco-sustainable approach to digestive diseases","authors":"Giovanni Cammarota, Gianluca Ianiro","doi":"10.1038/s41575-024-00983-4","DOIUrl":"10.1038/s41575-024-00983-4","url":null,"abstract":"Gastroenterology as a specialty can make a substantial contribution to reducing the carbon footprint of the health-care system. Concrete actions are needed to increase awareness, education and evidence-based knowledge on eco-sustainable diagnostic and therapeutic approaches to digestive diseases.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":45.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterizing the genomic landscape of colorectal cancer 描述结直肠癌的基因组特征
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-09-09 DOI: 10.1038/s41575-024-00988-z
Jordan Hindson
{"title":"Characterizing the genomic landscape of colorectal cancer","authors":"Jordan Hindson","doi":"10.1038/s41575-024-00988-z","DOIUrl":"10.1038/s41575-024-00988-z","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":45.9,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142158960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ammonia-induced stress response in liver disease progression and hepatic encephalopathy 肝病进展和肝性脑病中氨诱导的应激反应
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-09-09 DOI: 10.1038/s41575-024-00970-9
Rocío Gallego-Durán, Anna Hadjihambi, Javier Ampuero, Christopher F. Rose, Rajiv Jalan, Manuel Romero-Gómez
{"title":"Ammonia-induced stress response in liver disease progression and hepatic encephalopathy","authors":"Rocío Gallego-Durán, Anna Hadjihambi, Javier Ampuero, Christopher F. Rose, Rajiv Jalan, Manuel Romero-Gómez","doi":"10.1038/s41575-024-00970-9","DOIUrl":"10.1038/s41575-024-00970-9","url":null,"abstract":"Ammonia levels are orchestrated by a series of complex interrelated pathways in which the urea cycle has a central role. Liver dysfunction leads to an accumulation of ammonia, which is toxic and is strongly associated with disruption of potassium homeostasis, mitochondrial dysfunction, oxidative stress, inflammation, hypoxaemia and dysregulation of neurotransmission. Hyperammonaemia is a hallmark of hepatic encephalopathy and has been strongly associated with liver-related outcomes in patients with cirrhosis and liver failure. In addition to the established role of ammonia as a neurotoxin in the pathogenesis of hepatic encephalopathy, an increasing number of studies suggest that it can lead to hepatic fibrosis progression, sarcopenia, immune dysfunction and cancer. However, elevated systemic ammonia levels are uncommon in patients with metabolic dysfunction-associated steatotic liver disease. A clear causal relationship between ammonia-induced immune dysfunction and risk of infection has not yet been definitively proven. In this Review, we discuss the mechanisms by which ammonia produces its diverse deleterious effects and their clinical relevance in liver diseases, the importance of measuring ammonia levels for the diagnosis of hepatic encephalopathy, the prognosis of patients with cirrhosis and liver failure, and how our knowledge of inter-organ ammonia metabolism is leading to the development of novel therapeutic approaches. This Review describes inter-organ ammonia metabolism in liver disease and mechanisms underlying the pathogenic effect of hyperammonaemia in hepatic encephalopathy, liver disease progression in metabolic dysfunction-associated steatotic liver disease, immune dysfunction and hepatocellular carcinoma. It also addresses the principles of treating hyperammonaemia.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":45.9,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142158949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GLP1 agonists: current and future landscape of clinical trials for patients with metabolic dysfunction GLP1 激动剂：针对代谢功能障碍患者的临床试验现状与未来展望
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-09-06 DOI: 10.1038/s41575-024-00977-2
Jonathan Goldney, Melanie J. Davies
{"title":"GLP1 agonists: current and future landscape of clinical trials for patients with metabolic dysfunction","authors":"Jonathan Goldney, Melanie J. Davies","doi":"10.1038/s41575-024-00977-2","DOIUrl":"10.1038/s41575-024-00977-2","url":null,"abstract":"Guidelines currently recommend organ-specific management of obesity-related complications. Agents that agonize glucagon-like peptide 1 receptors, including those that co-agonize other anorexigenic hormone receptors, lead to substantial weight loss and benefits in people with varying obesity-related complications, with further trials underway. These medications enable cause-specific management of obesity complications.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":45.9,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142144269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI-based tool for scoring MASH histology 基于人工智能的 MASH 组织学评分工具
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-09-06 DOI: 10.1038/s41575-024-00987-0
Jordan Hindson
{"title":"AI-based tool for scoring MASH histology","authors":"Jordan Hindson","doi":"10.1038/s41575-024-00987-0","DOIUrl":"10.1038/s41575-024-00987-0","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":45.9,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142142617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatic immune regulation and sex disparities 肝脏免疫调节与性别差异
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-09-05 DOI: 10.1038/s41575-024-00974-5
Patrizia Burra, Alberto Zanetto, Bernd Schnabl, Thomas Reiberger, Aldo J. Montano-Loza, Rosanna Asselta, Tom Hemming Karlsen, Frank Tacke
{"title":"Hepatic immune regulation and sex disparities","authors":"Patrizia Burra, Alberto Zanetto, Bernd Schnabl, Thomas Reiberger, Aldo J. Montano-Loza, Rosanna Asselta, Tom Hemming Karlsen, Frank Tacke","doi":"10.1038/s41575-024-00974-5","DOIUrl":"https://doi.org/10.1038/s41575-024-00974-5","url":null,"abstract":"<p>Chronic liver disease is a major cause of morbidity and mortality worldwide. Epidemiology, clinical phenotype and response to therapies for gastrointestinal and liver diseases are commonly different between women and men due to sex-specific hormonal, genetic and immune-related factors. The hepatic immune system has unique regulatory functions that promote the induction of intrahepatic tolerance, which is key for maintaining liver health and homeostasis. In liver diseases, hepatic immune alterations are increasingly recognized as a main cofactor responsible for the development and progression of chronic liver injury and fibrosis. In this Review, we discuss the basic mechanisms of sex disparity in hepatic immune regulation and how these mechanisms influence and modify the development of autoimmune liver diseases, genetic liver diseases, portal hypertension and inflammation in chronic liver disease. Alterations in gut microbiota and their crosstalk with the hepatic immune system might affect the progression of liver disease in a sex-specific manner, creating potential opportunities for novel diagnostic and therapeutic approaches to be evaluated in clinical trials. Finally, we identify and propose areas for future basic, translational and clinical research that will advance our understanding of sex disparities in hepatic immunity and liver disease.</p>","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":65.1,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142138029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Consequences of bathroom restriction on transgender individuals with gastrointestinal conditions in the United States 浴室限制对美国患有肠胃疾病的变性人的影响
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-09-02 DOI: 10.1038/s41575-024-00975-4
Cass D. Condray, Kira L. Newman, Victor G. Chedid
{"title":"Consequences of bathroom restriction on transgender individuals with gastrointestinal conditions in the United States","authors":"Cass D. Condray,&nbsp;Kira L. Newman,&nbsp;Victor G. Chedid","doi":"10.1038/s41575-024-00975-4","DOIUrl":"10.1038/s41575-024-00975-4","url":null,"abstract":"Bathroom ban legislation is increasing throughout the United States, and little is known about the effect on transgender and gender-nonconforming individuals with chronic gastrointestinal conditions. Efforts should be made to raise awareness and address the knowledge gaps.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":null,"pages":null},"PeriodicalIF":45.9,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142117993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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