Nature Reviews Gastroenterology &Hepatology最新文献

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Author Correction: Classifying compounds as prebiotics — scientific perspectives and recommendations 作者更正:将化合物归类为益生元--科学视角和建议
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-10-16 DOI: 10.1038/s41575-024-01012-0
Robert Hutkins, Jens Walter, Glenn R. Gibson, Cassandre Bedu-Ferrari, Karen Scott, Daniel J. Tancredi, Anisha Wijeyesekera, Mary Ellen Sanders
{"title":"Author Correction: Classifying compounds as prebiotics — scientific perspectives and recommendations","authors":"Robert Hutkins, Jens Walter, Glenn R. Gibson, Cassandre Bedu-Ferrari, Karen Scott, Daniel J. Tancredi, Anisha Wijeyesekera, Mary Ellen Sanders","doi":"10.1038/s41575-024-01012-0","DOIUrl":"https://doi.org/10.1038/s41575-024-01012-0","url":null,"abstract":"<p>Correction to: <i>Nature Reviews Gastroenterology &amp; Hepatology</i> https://doi.org/10.1038/s41575-024-00981-6, published online 2 October 2024.</p>","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"24 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142439734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liraglutide treatment in children with obesity 利拉鲁肽治疗儿童肥胖症
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-10-15 DOI: 10.1038/s41575-024-01010-2
Eleni Kotsiliti
{"title":"Liraglutide treatment in children with obesity","authors":"Eleni Kotsiliti","doi":"10.1038/s41575-024-01010-2","DOIUrl":"10.1038/s41575-024-01010-2","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 12","pages":"829-829"},"PeriodicalIF":45.9,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142435977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liver transplantation plus chemotherapy improved survival in patients with colorectal liver metastasis 肝移植加化疗可提高结直肠肝转移患者的生存率
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-10-15 DOI: 10.1038/s41575-024-01011-1
Eleni Kotsiliti
{"title":"Liver transplantation plus chemotherapy improved survival in patients with colorectal liver metastasis","authors":"Eleni Kotsiliti","doi":"10.1038/s41575-024-01011-1","DOIUrl":"10.1038/s41575-024-01011-1","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 12","pages":"829-829"},"PeriodicalIF":45.9,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142435978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An expert panel Consensus Statement on ALD without experts by experience 无专家经验的 ALD 专家小组共识声明
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-10-14 DOI: 10.1038/s41575-024-00994-1
Tamar Avades, Victoria Allgar, Tom Thompson, Ashwin Dhanda
{"title":"An expert panel Consensus Statement on ALD without experts by experience","authors":"Tamar Avades,&nbsp;Victoria Allgar,&nbsp;Tom Thompson,&nbsp;Ashwin Dhanda","doi":"10.1038/s41575-024-00994-1","DOIUrl":"10.1038/s41575-024-00994-1","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 12","pages":"885-885"},"PeriodicalIF":45.9,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41575-024-00994-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to ‘An expert panel Consensus Statement on ALD without experts by experience’ 对 "没有专家经验的 ALD 专家小组共识声明 "的答复
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-10-14 DOI: 10.1038/s41575-024-00995-0
Katie Witkiewitz, Jessica L. Mellinger, Brian P. Lee, Srinivasan Dasarathy, Laura E. Nagy, Mack C. Mitchell
{"title":"Reply to ‘An expert panel Consensus Statement on ALD without experts by experience’","authors":"Katie Witkiewitz,&nbsp;Jessica L. Mellinger,&nbsp;Brian P. Lee,&nbsp;Srinivasan Dasarathy,&nbsp;Laura E. Nagy,&nbsp;Mack C. Mitchell","doi":"10.1038/s41575-024-00995-0","DOIUrl":"10.1038/s41575-024-00995-0","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 12","pages":"886-886"},"PeriodicalIF":45.9,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41575-024-00995-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anticoagulants in cirrhosis: main concerns 肝硬化患者的抗凝剂:主要关注点
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-10-11 DOI: 10.1038/s41575-024-00998-x
Elena Campello, Luca Fabris, Paolo Simioni
{"title":"Anticoagulants in cirrhosis: main concerns","authors":"Elena Campello,&nbsp;Luca Fabris,&nbsp;Paolo Simioni","doi":"10.1038/s41575-024-00998-x","DOIUrl":"10.1038/s41575-024-00998-x","url":null,"abstract":"Management of anticoagulation in cirrhosis is challenging because of the concomitant risk of both thromboembolism and bleeding complications. Randomized controlled studies are lacking. Direct oral anticoagulants seem to be the most manageable option. However, for patients with Child C cirrhosis, the only safer anticoagulant strategy, currently, is low-molecular-weight heparin.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 12","pages":"827-828"},"PeriodicalIF":45.9,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142404907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Hepatic immune regulation and sex disparities 作者更正:肝脏免疫调节与性别差异
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-10-10 DOI: 10.1038/s41575-024-01007-x
Patrizia Burra, Alberto Zanetto, Bernd Schnabl, Thomas Reiberger, Aldo J. Montano-Loza, Rosanna Asselta, Tom Hemming Karlsen, Frank Tacke
{"title":"Author Correction: Hepatic immune regulation and sex disparities","authors":"Patrizia Burra,&nbsp;Alberto Zanetto,&nbsp;Bernd Schnabl,&nbsp;Thomas Reiberger,&nbsp;Aldo J. Montano-Loza,&nbsp;Rosanna Asselta,&nbsp;Tom Hemming Karlsen,&nbsp;Frank Tacke","doi":"10.1038/s41575-024-01007-x","DOIUrl":"10.1038/s41575-024-01007-x","url":null,"abstract":"","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 12","pages":"887-887"},"PeriodicalIF":45.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41575-024-01007-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142397831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digital twins are integral to personalizing medicine and improving public health 数字双胞胎是个性化医疗和改善公共卫生不可或缺的一部分
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-10-09 DOI: 10.1038/s41575-024-00992-3
Brian Johnson, Kit Curtius
{"title":"Digital twins are integral to personalizing medicine and improving public health","authors":"Brian Johnson,&nbsp;Kit Curtius","doi":"10.1038/s41575-024-00992-3","DOIUrl":"10.1038/s41575-024-00992-3","url":null,"abstract":"Digital twins provide a framework to advance the field of personalized medicine by generating clinically actionable strategies that leverage individualized data as well as current and emerging research. Strong interdisciplinary teamwork, specific funding mechanisms and integration of key biological details such as somatic evolution are necessary for the effective adoption of digital twins in medicine.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 11","pages":"740-741"},"PeriodicalIF":45.9,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142385079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interpreting modern randomized controlled trials of medical therapy in inflammatory bowel disease 解读炎症性肠病医学疗法的现代随机对照试验
IF 45.9 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-10-08 DOI: 10.1038/s41575-024-00989-y
Christopher Ma, Vipul Jairath, Brian G. Feagan, Laurent Peyrin-Biroulet, Silvio Danese, Bruce E. Sands, Remo Panaccione
{"title":"Interpreting modern randomized controlled trials of medical therapy in inflammatory bowel disease","authors":"Christopher Ma,&nbsp;Vipul Jairath,&nbsp;Brian G. Feagan,&nbsp;Laurent Peyrin-Biroulet,&nbsp;Silvio Danese,&nbsp;Bruce E. Sands,&nbsp;Remo Panaccione","doi":"10.1038/s41575-024-00989-y","DOIUrl":"10.1038/s41575-024-00989-y","url":null,"abstract":"Treatment options for the medical management of inflammatory bowel disease (IBD) have expanded substantially over the past decade. Multiple classes of advanced therapies, including both monoclonal antibodies and novel oral small molecules, are now available for the treatment of moderately-to-severely active Crohn’s disease and ulcerative colitis, highlighted by the approvals of the first IL23p19 antagonists, selective Janus kinase inhibitors and sphingosine-1-phosphate receptor modulators. These advances have been accompanied by the identification of novel targets and the rapid growth in both the number and size of IBD clinical trials. Over a dozen landmark randomized controlled trials (RCTs) have been completed in the past 5 years, including the first head-to-head biologic trials, the first combination biologic studies, and multiple phase III registrational trials of novel compounds with new co-primary and composite end points that will change the treatment landscape for years to come. Importantly, the methodology of RCTs in IBD has evolved substantially, with new trial designs, evaluation of unique patient populations, and different types of efficacy and safety end points being key innovations. In this Review, we provide a comprehensive evaluation of how modern RCTs of IBD medical therapies have evolved and the implications for their appraisal that will help guide the application of these data to clinical practice. In this Review, Ma and colleagues discuss the evolution in clinical trial designs for inflammatory bowel disease (IBD), their implications for clinical care, and identify future directions for the next generation of IBD studies.","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"21 11","pages":"792-808"},"PeriodicalIF":45.9,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41575-024-00989-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142384301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Classifying compounds as prebiotics — scientific perspectives and recommendations 将化合物分类为益生元--科学视角和建议
IF 65.1 1区 医学
Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-10-02 DOI: 10.1038/s41575-024-00981-6
Robert Hutkins, Jens Walter, Glenn R. Gibson, Cassandre Bedu-Ferrari, Karen Scott, Daniel J. Tancredi, Anisha Wijeyesekera, Mary Ellen Sanders
{"title":"Classifying compounds as prebiotics — scientific perspectives and recommendations","authors":"Robert Hutkins, Jens Walter, Glenn R. Gibson, Cassandre Bedu-Ferrari, Karen Scott, Daniel J. Tancredi, Anisha Wijeyesekera, Mary Ellen Sanders","doi":"10.1038/s41575-024-00981-6","DOIUrl":"https://doi.org/10.1038/s41575-024-00981-6","url":null,"abstract":"<p>Microbiomes provide key contributions to health and potentially important therapeutic targets. Conceived nearly 30 years ago, the prebiotic concept posits that targeted modulation of host microbial communities through the provision of selectively utilized growth substrates provides an effective approach to improving health. Although the basic tenets of this concept remain the same, it is timely to address certain challenges pertaining to prebiotics, including establishing that prebiotic-induced microbiota modulation causes the health outcome, determining which members within a complex microbial community directly utilize specific substrates in vivo and when those microbial effects sufficiently satisfy selectivity requirements, and clarification of the scientific principles on which the term ‘prebiotic’ is predicated to inspire proper use. In this Expert Recommendation, we provide a framework for the classification of compounds as prebiotics. We discuss ecological principles by which substrates modulate microbiomes and methodologies useful for characterizing such changes. We then propose statistical approaches that can be used to establish causal links between selective effects on the microbiome and health effects on the host, which can help address existing challenges. We use this information to provide the minimum criteria needed to classify compounds as prebiotics. Furthermore, communications to consumers and regulatory approaches to prebiotics worldwide are discussed.</p>","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"191 1","pages":""},"PeriodicalIF":65.1,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142363258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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