An autoimmune response against transglutaminase 2 in coeliac disease

IF 51 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Nature Reviews Gastroenterology &Hepatology Pub Date : 2025-07-30 DOI:10.1038/s41575-025-01109-0

Eleni Kotsiliti

引用次数: 0

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乳糜泻患者对转谷氨酰胺酶2的自身免疫反应

发表在《胃肠病学》（Gastroenterology）杂志上的一项新研究调查了乳糜泻中针对谷氨酰胺转酶2 （TG2）的自身免疫反应机制，重点关注TG2特异性B细胞如何与肠道中的谷蛋白肽相互作用。研究人员使用HLA-DQ2.5（一种与乳糜泻风险增加相关的变体）敲入小鼠模型，通过过继性转移设计，携带tg2特异性B细胞和谷蛋白特异性CD4+ T细胞。随后，通过口服一种叫做troybody的抗原复合物对小鼠进行免疫。troybody是一种旨在将麸质T细胞表位传递给B细胞的抗体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Gastroenterology &Hepatology 医学-胃肠肝病学

CiteScore

52.30

自引率

0.60%

发文量

147

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.