ssri类药物与抑郁症:肠脑通讯的作用

IF 51 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Lin Y. Hung
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引用次数: 0

摘要

抗抑郁药物的发展很大程度上是基于一种观念,即单胺能功能的缺乏,特别是去甲肾上腺素的缺乏,被认为是导致抑郁症的原因。第一代抗抑郁药物,三环抗抑郁药和单胺氧化酶抑制剂,因此被开发出来分别抑制单胺再摄取或其降解。虽然这两类药物都有一定的效果,但它们都有副作用(如头晕、便秘和单胺氧化酶抑制剂的高毒性),这在很大程度上是由于它们缺乏目标特异性。除了去甲肾上腺素,5-羟色胺(也被称为5-HT)是另一种尚未被发现的单胺,它对情绪有重要的调节作用。1974年,一项开创性的研究描述了第一种选择性5-羟色胺再摄取抑制剂(SSRI),盐酸氟西汀,专门抑制5-羟色胺的摄取。Wong等人利用离体大鼠脑,发现氟西汀治疗的大脑(大脑皮层和脑干)突触体对5-HT摄取的选择性抑制,而不影响其他单胺的摄取。与另一种三环抗抑郁药氯丙咪嗪(也称为氯丙咪嗪)相比,氟西汀在抑制5-羟色胺摄取方面明显更有效(56%对24%),并具有持续24小时的抑制作用。在确定抑制5-羟色胺再摄取可以治疗抑郁症后,同一研究小组后来成功地用氟西汀治疗了重度抑郁症患者,同时观察到其他抗抑郁药常见的最小不良反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
SSRIs and depression: role of gut–brain communication
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来源期刊
CiteScore
52.30
自引率
0.60%
发文量
147
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.
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