{"title":"Diet-driven microbiome restoration associated with cardiometabolic benefits","authors":"Jordan Hindson","doi":"10.1038/s41575-025-01067-7","DOIUrl":null,"url":null,"abstract":"<p>The effects of industrialization on the human gut microbiome have been associated with an increased risk of non-communicable diseases. In a new study published in <i>Cell</i>, researchers have investigated the effect of a non-industrialized-type diet on the gut microbiome and on the risk of chronic diseases.</p><p>The researchers conducted a randomized controlled feeding trial in 30 healthy Canadian adults. Participants were randomized to consume either a non-industrialized-type diet or their normal diet, and to receive a dose of either <i>Limosilactobacillus reuteri</i> or placebo. The high-fibre, mostly plant-based diet, termed the non-industrialized microbiome restore (NiMe) diet, was designed based on foods consumed in rural Papau New Guinea. <i>L. reuteri</i> is a bacterium not commonly observed in industrialized gut microbiomes.</p>","PeriodicalId":18793,"journal":{"name":"Nature Reviews Gastroenterology &Hepatology","volume":"27 6 1","pages":""},"PeriodicalIF":45.9000,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Gastroenterology &Hepatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41575-025-01067-7","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
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Abstract
The effects of industrialization on the human gut microbiome have been associated with an increased risk of non-communicable diseases. In a new study published in Cell, researchers have investigated the effect of a non-industrialized-type diet on the gut microbiome and on the risk of chronic diseases.
The researchers conducted a randomized controlled feeding trial in 30 healthy Canadian adults. Participants were randomized to consume either a non-industrialized-type diet or their normal diet, and to receive a dose of either Limosilactobacillus reuteri or placebo. The high-fibre, mostly plant-based diet, termed the non-industrialized microbiome restore (NiMe) diet, was designed based on foods consumed in rural Papau New Guinea. L. reuteri is a bacterium not commonly observed in industrialized gut microbiomes.
期刊介绍：
Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication.
The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information.
Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.
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