Micromachines最新文献_第10页

An Organ-on-a-Chip Modular Platform with Integrated Immunobiosensors for Monitoring the Extracellular Environment. 一种集成免疫生物传感器的器官芯片模块化平台，用于监测细胞外环境。

IF 3 3区工程技术

Micromachines Pub Date : 2025-06-25 DOI: 10.3390/mi16070740

Anastasia Kanioura, Myrto Kyriaki Filippidou, Dimitra Tsounidi, Panagiota S Petrou, Stavros Chatzandroulis, Angeliki Tserepi

{"title":"An Organ-on-a-Chip Modular Platform with Integrated Immunobiosensors for Monitoring the Extracellular Environment.","authors":"Anastasia Kanioura, Myrto Kyriaki Filippidou, Dimitra Tsounidi, Panagiota S Petrou, Stavros Chatzandroulis, Angeliki Tserepi","doi":"10.3390/mi16070740","DOIUrl":"10.3390/mi16070740","url":null,"abstract":"OoC systems employing human cells mirror the functionality of human organs and faithfully simulate their physiological microfluidic environment. Despite the potential of OoC technology in emulating tissue complexity, a significant gap persists in the continuous real-time monitoring of cellular behaviors and their responses to external stimuli, arising from the lack of biosensors integrated onto OoC microfluidic platforms. Addressing this limitation constitutes the primary objective of this study. By developing and incorporating biosensors onto a modular integrated OoC platform, we aim to enable the monitoring of changes taking place in the cellular environment under various stimuli in real time. An in-series modular integration of a biosensor array into an OoC platform is demonstrated herein, along with its potential to sustain human cell proliferation and accommodate the detection of IL-6, as an example of a mediator protein secreted as part of the immune response to inflammation. The implementation of commercially fabricated PCB components also addresses the issue of cost efficiency and manufacturing scaling-up of sensor-integrated OoCs. This advancement will not only enhance the accuracy and reliability of preclinical studies, but also pave the way for improved drug development and disease treatment.","PeriodicalId":18508,"journal":{"name":"Micromachines","volume":"16 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12300027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Photonic Crystal Fiber-Based SPR Biosensors: Design Strategies, Plasmonic Materials, and Applications. 基于光子晶体光纤的SPR生物传感器的最新进展：设计策略、等离子体材料和应用。

IF 3 3区工程技术

Micromachines Pub Date : 2025-06-25 DOI: 10.3390/mi16070747

Ayushman Ramola, Amit Kumar Shakya, Vinay Kumar, Arik Bergman

{"title":"Recent Advances in Photonic Crystal Fiber-Based SPR Biosensors: Design Strategies, Plasmonic Materials, and Applications.","authors":"Ayushman Ramola, Amit Kumar Shakya, Vinay Kumar, Arik Bergman","doi":"10.3390/mi16070747","DOIUrl":"10.3390/mi16070747","url":null,"abstract":"This article presents a comprehensive overview of recent advancements in photonic crystal fiber (PCF)-based sensors, with a particular focus on the surface plasmon resonance (SPR) phenomenon for biosensing. With their ability to modify core and cladding structures, PCFs offer exceptional control over light guidance, dispersion management, and light confinement, making them highly suitable for applications in refractive index (RI) sensing, biomedical imaging, and nonlinear optical phenomena such as fiber tapering and supercontinuum generation. SPR is a highly sensitive optical phenomenon, which is widely integrated with PCFs to enhance detection performance through strong plasmonic interactions at metal-dielectric interfaces. The combination of PCF and SPR technologies has led to the development of innovative sensor geometries, including D-shaped fibers, slotted-air-hole structures, and internal external metal coatings, each optimized for specific sensing goals. These PCF-SPR-based sensors have shown promising results in detecting biomolecular targets such as excess cholesterol, glucose, cancer cells, DNA, and proteins. Furthermore, this review provides an in-depth analysis of key design parameters, plasmonic materials, and sensor models used in PCF-SPR configurations, highlighting their comparative performance metrics and application prospects in medical diagnostics, environmental monitoring, and chemical analysis. Thus, an exhaustive analysis of various sensing parameters, plasmonic materials, and sensor models used in PCF-SPR sensors is presented and explored in this article.","PeriodicalId":18508,"journal":{"name":"Micromachines","volume":"16 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12298052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress and Application Scenarios of Wire + Arc Additive Manufacturing: From Process Control to Performance Evaluation. 线材+电弧增材制造的研究进展与应用场景：从过程控制到性能评价。

IF 3 3区工程技术

Micromachines Pub Date : 2025-06-25 DOI: 10.3390/mi16070749

Chun Guo, Qingcheng Lin, Ruizhang Hu, Suisong Wu

引用次数: 0

Theoretical Prediction of the Impact of Phosphorus Doping on the Elastic Constants of Silicon. 磷掺杂对硅弹性常数影响的理论预测。

IF 3 3区工程技术

Micromachines Pub Date : 2025-06-25 DOI: 10.3390/mi16070748

Azadeh Jafari, Behraad Bahreyni

{"title":"Theoretical Prediction of the Impact of Phosphorus Doping on the Elastic Constants of Silicon.","authors":"Azadeh Jafari, Behraad Bahreyni","doi":"10.3390/mi16070748","DOIUrl":"10.3390/mi16070748","url":null,"abstract":"Accurately controlling the mechanical properties of silicon is essential for developing high-performance micro-devices and systems. In this study, we investigate the influence of phosphorus doping on the elastic constants of silicon across a wide temperature range using a combination of tight-binding simulations and deformation potential theory. The mechanical properties were derived using Keyes's framework integrated with Fermi-Dirac statistics. The Goodwin-Skinner-Pettifor functional form was applied to estimate dopant-induced stress potentials and their effect on lattice stiffness. In particular, we investigated the change in elastic constants and their temperature dependence under ultra-high doping concentrations. The results show a monotonic decrease in c11 and a non-monotonic increase in c12 with both temperature and doping, while c44 remains relatively unaffected, consistent with experimental and theoretical studies. These changes are attributed to anisotropic carrier redistribution among conduction band valleys and strain-modulated interactions between valleys. The novelty of this work lies in the explicit, atomistically informed calculation of deformation potential constants using tight-binding parameters specific to phosphorus doping in silicon, enabling the accurate prediction of temperature-dependent elastic constants and anisotropic mechanical behaviour in emerging microsystem applications.","PeriodicalId":18508,"journal":{"name":"Micromachines","volume":"16 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12298610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A High Dynamic Range and Fast Response Logarithmic Amplifier Employing Slope-Adjustment and Power-Down Mode. 一种采用斜率调节和下电模式的高动态范围和快速响应对数放大器。

IF 3 3区工程技术

Micromachines Pub Date : 2025-06-25 DOI: 10.3390/mi16070741

Yanhu Wang, Rui Teng, Yuanjie Zhou, Mengchen Lu, Wei Ruan, Jiapeng Li

引用次数: 0

Double-Sided Fabrication of Low-Leakage-Current Through-Silicon Vias (TSVs) with High-Step-Coverage Liner/Barrier Layers. 具有高台阶覆盖衬垫/阻挡层的低漏电流硅通孔（tsv）的双面制造。

IF 3 3区工程技术

Micromachines Pub Date : 2025-06-25 DOI: 10.3390/mi16070750

Baoyan Yang, Houjun Sun, Kaiqiang Zhu, Xinghua Wang

引用次数: 0

A Dialysis Membrane-Integrated Microfluidic Device for Controlled Drug Retention and Nutrient Supply. 透析膜集成微流控装置控制药物保留和营养供应。

IF 3 3区工程技术

Micromachines Pub Date : 2025-06-25 DOI: 10.3390/mi16070745

Hajime Miyashita, Yuya Ito, Kenta Shinha, Hiroko Nakamura, Hiroshi Kimura

{"title":"A Dialysis Membrane-Integrated Microfluidic Device for Controlled Drug Retention and Nutrient Supply.","authors":"Hajime Miyashita, Yuya Ito, Kenta Shinha, Hiroko Nakamura, Hiroshi Kimura","doi":"10.3390/mi16070745","DOIUrl":"10.3390/mi16070745","url":null,"abstract":"Traditional pre-clinical drug evaluation methods, including animal experiments and static cell cultures using human-derived cells, face critical limitations such as interspecies differences, ethical concerns, and poor physiological relevance. More recently, microphysiological systems (MPSs) that use microfluidic devices to mimic in vivo conditions have emerged as promising platforms. By enabling perfusion cell culture and incorporating human-derived cells, MPSs can evaluate drug efficacy and toxicity in a more human-relevant manner. However, standard MPS protocols rely on discrete medium changes, causing abrupt changes in drug concentrations that do not reflect the continuous pharmacokinetics seen in vivo. To overcome this limitation, we developed a Dialysis Membrane-integrated Microfluidic Device (DMiMD) which maintains continuous drug concentrations through selective medium change via a dialysis membrane. The membrane's molecular weight cut-off (MWCO) enables the retention of high-molecular-weight drugs while facilitating the passage of essential low-molecular-weight nutrients such as glucose. We validated the membrane's molecular selectivity and confirmed effective nutrient supply using cells. Additionally, anticancer drug efficacy was evaluated under continuously changing drug concentrations, demonstrating that the DMiMD successfully mimics in vivo drug exposure dynamics. These results indicate that the DMiMD offers a robust in vitro platform for accurate assessment of drug efficacy and toxicity, bridging the gap between conventional static assays and the physiological complexities of the human body.","PeriodicalId":18508,"journal":{"name":"Micromachines","volume":"16 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12299900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advancements in Metal-Organic Framework-Based Microfluidic Chips for Biomedical Applications. 生物医学用金属有机框架微流控芯片的研究进展。

IF 3 3区工程技术

Micromachines Pub Date : 2025-06-24 DOI: 10.3390/mi16070736

Alemayehu Kidanemariam, Sungbo Cho

{"title":"Recent Advancements in Metal-Organic Framework-Based Microfluidic Chips for Biomedical Applications.","authors":"Alemayehu Kidanemariam, Sungbo Cho","doi":"10.3390/mi16070736","DOIUrl":"10.3390/mi16070736","url":null,"abstract":"The integration of metal-organic frameworks (MOFs) with microfluidic technologies has opened new frontiers in biomedical diagnostics and therapeutics. Microfluidic chips offer precise fluid control, low reagent use, and high-throughput capabilities features further enhanced by MOFs' ample surface area, adjustable porosity, and catalytic activity. Together, they form powerful lab-on-a-chip platforms for sensitive biosensing, drug delivery, tissue engineering, and microbial detection. This review highlights recent advances in MOF-based microfluidic systems, focusing on material innovations, fabrication methods, and diagnostic applications. Particular emphasis is placed on MOF nanozymes, which enhance biochemical reactions for multiplexed testing and rapid pathogen identification. Challenges such as stability, biocompatibility, and manufacturing scalability are addressed, along with emerging trends like responsive MOFs, AI-assisted design, and clinical translation strategies. By bridging MOF chemistry and microfluidic engineering, these systems hold great promise for next-generation biomedical technologies.","PeriodicalId":18508,"journal":{"name":"Micromachines","volume":"16 7","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12298669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of Three-Dimensional Electric Field Sensors. 三维电场传感器研究进展。

IF 3 3区工程技术

Micromachines Pub Date : 2025-06-24 DOI: 10.3390/mi16070737

Xiaonan Li, Yu Gu, Zehao Li, Zijian He, Pengfei Yang, Chunrong Peng

引用次数: 0

Fruit-Fly-Optimized Weighted Averaging Algorithm for Data Fusion in MEMS IMU Array. 基于果蝇优化的MEMS IMU阵列数据融合加权平均算法。

IF 3 3区工程技术

Micromachines Pub Date : 2025-06-24 DOI: 10.3390/mi16070739

Ting Zhu, Gao Peng, Jianping Li, Jiawei Xuan, Jingbei Tian

引用次数: 0