Letters in Applied Microbiology最新文献_第3页

Ozonated water hydrogel: a promising therapeutic agent for targeting high-risk HPV infections. 臭氧水凝胶：一种针对高危HPV感染的有前途的治疗剂。

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-05-01 DOI: 10.1093/lambio/ovaf066

Nini Chen, Yong Xu, Zhongdong Zhang, Jing Leng, Chen Zhang

{"title":"Ozonated water hydrogel: a promising therapeutic agent for targeting high-risk HPV infections.","authors":"Nini Chen, Yong Xu, Zhongdong Zhang, Jing Leng, Chen Zhang","doi":"10.1093/lambio/ovaf066","DOIUrl":"10.1093/lambio/ovaf066","url":null,"abstract":"Cervical cancer, primarily caused by high-risk human papillomavirus (HPV) subtypes 16 and 18, remains a global health challenge, particularly in resource-limited regions where HPV vaccine accessibility is constrained by cost and logistical barriers. This study investigates ozonated water (OW) and its hydrogel formulation (H-OW2) as novel antiviral agents against HPV. OW exhibited dose-dependent inactivation of HPV16/18 pseudoviruses, achieving >98% inhibition at 1 mg/l (OW3). However, unformulated OW demonstrated significant cytotoxicity at higher concentrations (49.24% cell viability for OW3) and rapid ozone decay (80% loss within 6 h). To address these limitations, H-OW2 was developed using a chitosan-calcium chloride hydrogel matrix. Remarkably, H-OW2 maintained >97% antiviral efficacy against both HPV subtypes for 14 days at room temperature, with negligible ozone degradation. The hydrogel formulation of OW also reduced oxidative stress in human cells, lowering reactive oxygen species levels to 4.046% and preserving mitochondrial membrane potential (92.05% of control). Critically, H-OW2 production costs are substantially lower than HPV vaccine, and its stability eliminates cold-chain requirements. These findings position H-OW2 as a cost-effective, stable, and safe topical prophylactic, offering a practical alternative or adjunct to vaccines in underserved populations. Further studies should validate its efficacy in vivo and optimize dosing regimens for clinical translation.","PeriodicalId":17962,"journal":{"name":"Letters in Applied Microbiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A strain of Paenibacillus polysaccharolyticus XY5 promotes fiber component degradation in a co-fermentation system of mulberry leaves and distillers' grains. 一株解多糖芽孢杆菌XY5在桑叶和酒糟共发酵体系中促进纤维成分降解。

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-05-01 DOI: 10.1093/lambio/ovaf058

Yue Qiu, Xiaopeng Zhang, Ming Ying, Boyuan Tu, Kai Zhao, Die Hu, Pei Wang, Jingbo Liu, Yu Zeng

{"title":"A strain of Paenibacillus polysaccharolyticus XY5 promotes fiber component degradation in a co-fermentation system of mulberry leaves and distillers' grains.","authors":"Yue Qiu, Xiaopeng Zhang, Ming Ying, Boyuan Tu, Kai Zhao, Die Hu, Pei Wang, Jingbo Liu, Yu Zeng","doi":"10.1093/lambio/ovaf058","DOIUrl":"https://doi.org/10.1093/lambio/ovaf058","url":null,"abstract":"With the increasing emphasis on environment and the concept of sustainable development, the wasted distillers' grains (DG) and mulberry leaves (ML), via mixed fermentation, are further developed into new feed resources. However, addressing the high cellulose content in the products of fermentation presents a substantial challenge for effectively harnessing their vast potential. This study identified a cellulose-degrading bacterium named Paenibacillus polysaccharolyticus XY5 through 16S rDNA sequencing technology. The bacterium was used to ferment a mixture of DG and ML under anaerobic solid-state fermentation conditions, and the microbial community structure within the mixture was analyzed using high-throughput sequencing technology. The results indicate that the degradation rate increased by 21.97% compared to the natural fermentation control group. Analysis of the microbial community structure revealed that the relative abundance of Firmicutes increased from 22.53% to 39.68%, while that of Bacteroidetes changed from 66.44% to 51.89%. Additionally, the relative abundances of the genera Weizmannia and Paenibacillus increased. Redundancy analysis results revealed that Paenibacillus was the most correlated with neutral detergent fiber degradation. In summary, after inoculating with P. polysaccharolyticus, the mixed fermentation approach effectively reduced NDF content, altered microbial community structure, and enhanced potential feed value.","PeriodicalId":17962,"journal":{"name":"Letters in Applied Microbiology","volume":"78 5","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Staphylococcus aureus in Rwandan dogs predominantly representing human-associated lineages. 金黄色葡萄球菌在卢旺达狗主要代表人类相关谱系。

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-05-01 DOI: 10.1093/lambio/ovaf065

Lydia Marek, Emmanuel Irimaso, Jean Bosco Turikumwenayo, Beatrice Mukamulisa, Prudence Ndishimye, Flora Muragijemariya, Adriana Cabal-Rosel, Amelie Desvars-Larrive, Otto W Fischer, Michael P Szostak, Elke Müller, Sascha D Braun, Monika Ehling-Schulz, Joachim Spergser, Tom Grunert, Werner Ruppitsch, Andrea T Feßler, Stefan Schwarz, Stefan Monecke, Ralf Ehricht, Frank Künzel, Igor Loncaric

{"title":"Staphylococcus aureus in Rwandan dogs predominantly representing human-associated lineages.","authors":"Lydia Marek, Emmanuel Irimaso, Jean Bosco Turikumwenayo, Beatrice Mukamulisa, Prudence Ndishimye, Flora Muragijemariya, Adriana Cabal-Rosel, Amelie Desvars-Larrive, Otto W Fischer, Michael P Szostak, Elke Müller, Sascha D Braun, Monika Ehling-Schulz, Joachim Spergser, Tom Grunert, Werner Ruppitsch, Andrea T Feßler, Stefan Schwarz, Stefan Monecke, Ralf Ehricht, Frank Künzel, Igor Loncaric","doi":"10.1093/lambio/ovaf065","DOIUrl":"https://doi.org/10.1093/lambio/ovaf065","url":null,"abstract":"The present study aimed at examining the nasal and ear carriage of Staphylococcus aureus of Rwandan dogs and cats. Sixty-five S. aureus isolates were detected, all originating from the nostrils of dogs. Resistance to penicillin, penicillin/erythromycin/clindamycin, penicillin/tetracycline, and tetracycline solely was observed. The isolates were assigned to 23 different spa types, among them three novel (t21589, t21661, and t21662) variants, associated with eleven clonal complexes (CCs) (CC1, CC5, CC12, CC15, CC22, CC30, CC45, CC97, CC152, CC707, and CC834). Four isolates could not be assigned to any known CC. MLST revealed that one of them belonged to the new sequence type (ST) 9069. Panton-Valentine leukocidin (PVL) genes (lukF-PV/lukS-PV), the bovine leukocidin genes (lukM/lukF-P83), the toxic shock syndrome toxin gene tst-1, and various virulence-associated genes were detected. These findings demonstrate the dogs are colonized with human lineages of S. aureus. Coupled with the limited availability of S. aureus data from human medicine in Rwanda underscores the importance of hygiene measures and supports the need for a rigorous One-Health Surveillance program of the companion animals-human interface.","PeriodicalId":17962,"journal":{"name":"Letters in Applied Microbiology","volume":"78 5","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbiota dysbiosis and the anti-inflammatory effects of probiotic-derived cell-free supernatants in HT-29 cells: insights into early stage colorectal cancer. 肠道菌群失调和HT-29细胞中益生菌来源的无细胞上清液的抗炎作用：对早期结直肠癌的见解

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-05-01 DOI: 10.1093/lambio/ovaf060

Nafiseh Erfanian, Tahmine Tavakoli, Mohammad A Mahdiabadi, Saeed Nasseri, Hossein Safarpour, Tahereh Fakharian, Mohammad H Namaei

{"title":"Gut microbiota dysbiosis and the anti-inflammatory effects of probiotic-derived cell-free supernatants in HT-29 cells: insights into early stage colorectal cancer.","authors":"Nafiseh Erfanian, Tahmine Tavakoli, Mohammad A Mahdiabadi, Saeed Nasseri, Hossein Safarpour, Tahereh Fakharian, Mohammad H Namaei","doi":"10.1093/lambio/ovaf060","DOIUrl":"https://doi.org/10.1093/lambio/ovaf060","url":null,"abstract":"Colorectal cancer (CRC), the third most common cancer globally, is linked to gut microbiota imbalances. This study explores the association between gut microbiota composition and CRC, focusing on the therapeutic potential of probiotic-derived cell-free supernatants (CFSs). 50 participants, including 25 CRC patients and 25 healthy controls, were recruited and assessed for the relative abundance of six targeted gut bacterial species, including three probiotic strains (Lactobacillus acidophilus, Lacticaseibacillus rhamnosus, and Bifidobacteriumbreve) and three non-probiotic bacteria (Enterococcus faecalis, Streptococcus bovis, and Porphyromonas gingivalis), using absolute quantification real-time PCR (qRT-PCR). Additionally, the in vitro studies investigated the anti-inflammatory effects of CFSs extracted from cultured L. acidophilus, L. rhamnosus, and B. breve, both individually and as a combined cocktail. The results showed that CRC patients exhibited significant increases in non-probiotic bacteria alongside reductions in the beneficial probiotics. Moreover, while the CFSs from all three probiotics exhibited anti-inflammatory properties, the combined CFS cocktail demonstrated the most pronounced effect, significantly downregulating pro-inflammatory cytokines IL-6 and TNF-α in HT-29 colon epithelial cells. These findings emphasize microbial imbalances as potential biomarkers for early CRC detection and underscore the therapeutic promise of probiotic-derived CFSs, presenting innovative, non-invasive strategies for managing CRC-associated inflammation.","PeriodicalId":17962,"journal":{"name":"Letters in Applied Microbiology","volume":"78 5","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the virulence, genetic links, and enzyme profiles of bivalve-associated Vibrio parahaemolyticus from the southwest coast of India. 揭示了印度西南海岸双壳类相关副溶血性弧菌的毒力、遗传联系和酶谱。

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-05-01 DOI: 10.1093/lambio/ovaf069

Remya Bhaskaran, Krupesha Sharma Sulumane Ramachandra, Reynold Peter, Sumithra T Gopakumar, Murugadas Vaiyapuri, Rajan Vineeth, Ardhra Vijayan, Rithin R M, Sreenath K Ramanathan

{"title":"Unveiling the virulence, genetic links, and enzyme profiles of bivalve-associated Vibrio parahaemolyticus from the southwest coast of India.","authors":"Remya Bhaskaran, Krupesha Sharma Sulumane Ramachandra, Reynold Peter, Sumithra T Gopakumar, Murugadas Vaiyapuri, Rajan Vineeth, Ardhra Vijayan, Rithin R M, Sreenath K Ramanathan","doi":"10.1093/lambio/ovaf069","DOIUrl":"10.1093/lambio/ovaf069","url":null,"abstract":"The study investigated the virulence, enzymatic activity, and genetic variants of Vibrio parahaemolyticus isolates from bivalves. Isolates were screened for the tdh, trh, T3SS1, T3SS2 (α and β), and T6SS1 genes associated with human infections. The tdh was found in 2.6% of isolates and trh in 3.5%. None carried both tdh and trh, and no isolates harbored T3SS2α or T3SS2β genes. All isolates contained T3SS1 genes, and 64% expressed T6SS1. Enzyme profiling revealed significant lipase, gelatinase, amylase, cellulase, lecithinase, DNase, and caseinase production, implying their ability to function as virulence factors by helping pathogens invade tissues, damage cells, and evade the host's immune defenses, thereby promoting disease development. Additionally, pulsed field gel electrophoresis and ERIC-PCR analyses examined genetic variability and linkages among the isolates. These findings demonstrate the genetic and enzymatic heterogeneity of V. parahaemolyticus in bivalves, underscoring potential risks to human health.","PeriodicalId":17962,"journal":{"name":"Letters in Applied Microbiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibition of quorum sensing related virulence factor production in Pseudomonas aeruginosa PAO1 by Naringenin. 柚皮素对铜绿假单胞菌PAO1群体感应相关毒力因子产生的抑制作用。

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-04-09 DOI: 10.1093/lambio/ovaf041

Changquan Chen, Jinping Xiong, Meixin Wen, Fei Shi, Gang Ye, Ling Zhao, Wei Zhang, Fei Cao, Hongmei Yin, Yinglun Li, Huaqiao Tang

{"title":"Inhibition of quorum sensing related virulence factor production in Pseudomonas aeruginosa PAO1 by Naringenin.","authors":"Changquan Chen, Jinping Xiong, Meixin Wen, Fei Shi, Gang Ye, Ling Zhao, Wei Zhang, Fei Cao, Hongmei Yin, Yinglun Li, Huaqiao Tang","doi":"10.1093/lambio/ovaf041","DOIUrl":"https://doi.org/10.1093/lambio/ovaf041","url":null,"abstract":"The P. aeruginosa, widely spread and highly detrimental nosocomial pathogen, exhibits extensive intrinsic and acquired antibiotics resistance. Naringenin, a flavonoid compound, exhibits diverse pharmacological activities, especially in inhibiting the growth of many pathogenic bacteria. Our study revealed that naringenin showed significant inhibition on the virulence factors of P. aeruginosa at non bactericidal concentrations. At the concentration of 200 μg·mL-1, naringenin inhibited the swarming and swimming motility of P. aeruginosa, reduced pyocyanin secretion, and flagella assembly. Quantitative real-time polymerase chain reaction experiment was conducted, and the results showed that naringenin could reduce the expression of bacterial virulence factors related to P. aeruginosa. Naringenin inhibited bacterial adherence capability to cells in vitro. The larvae of Galleria mellonella showed a higher survival rate in treatment with naringenin in vivo. These findings suggested a promising role of naringenin in suppressing the virulence of P. aeruginosa, which encompasses the growth inhibition of various pathogenic bacteria. This indicates substantial potential for future therapeutic interventions targeting bacterial virulence.","PeriodicalId":17962,"journal":{"name":"Letters in Applied Microbiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing blueberries' safety: antimicrobial effects of alkyltrimethylammonium bromide against foodborne pathogens. 提高蓝莓的安全性：烷基三甲溴化铵对食源性病原体的抗菌作用。

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-04-01 DOI: 10.1093/lambio/ovaf042

Syed Ammar Hussain, Majher I Sarker, Tony Z Jin

引用次数: 0

Screening of drugs with potential antifungal activity for repurposing in the treatment of cryptococcosis. 隐球菌病治疗中潜在抗真菌活性药物的筛选。

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-04-01 DOI: 10.1093/lambio/ovaf045

Emanuel Almeida Moreira de Oliveira, Gabriella Freitas Ferreira, Karen Luise Lang

{"title":"Screening of drugs with potential antifungal activity for repurposing in the treatment of cryptococcosis.","authors":"Emanuel Almeida Moreira de Oliveira, Gabriella Freitas Ferreira, Karen Luise Lang","doi":"10.1093/lambio/ovaf045","DOIUrl":"10.1093/lambio/ovaf045","url":null,"abstract":"Current therapeutic alternatives for the treatment of cryptococcosis are scarce, highly toxic, expensive, and difficult to access. Therefore, the aim of this study was to evaluate the anticryptococcal potential of a collection of 27 drugs in vitro against several strains of Cryptococcus neoformans and Cryptococcus gattii. We investigated several parameters to evaluate the antifungal activity of the drugs: determination of minimum inhibitory concentration (MIC), combinatorial effects with fluconazole, kinetics of growth inhibition, post-antifungal effect (PAFE), and morphometric analyses at subinhibitory concentrations. Antiparasitics albendazole, fenbendazole, flubendazole, mebendazole, and antidepressants duloxetine and paroxetine showed antifungal activity with an MIC of 100 µmol l-1 or less for most strains tested. The results of the zero-interaction power model indicated additive effects for combination of fluconazole with drugs finasteride, hydroxyzine, and paroxetine. The combined treatments significantly improved the ability of fluconazole to kill C. neoformans ATCC H99. Same phenomenon occurred in the in vitro PAFE, as the combinations suppressed fungal growth more effectively than fluconazole alone. A significant reduction in capsule size was observed. Screening of the drug collection showed interesting results, with benzimidazoles antiparasitics and serotonin and norepinephrine reuptake inhibitors in foreground. Finasteride, hydroxyzine, and paroxetine significantly improved activity of fluconazole in vitro.","PeriodicalId":17962,"journal":{"name":"Letters in Applied Microbiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioprospecting for probiotics and other technological aspects of the bacteria isolated from goat milk. 羊奶中益生菌及其分离技术的生物勘探。

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-04-01 DOI: 10.1093/lambio/ovaf050

Namita Ashish Singh, Jyoti, Shakshi, Vidhi Jain, Jaya, Nitish Rai, Rahul Jain

{"title":"Bioprospecting for probiotics and other technological aspects of the bacteria isolated from goat milk.","authors":"Namita Ashish Singh, Jyoti, Shakshi, Vidhi Jain, Jaya, Nitish Rai, Rahul Jain","doi":"10.1093/lambio/ovaf050","DOIUrl":"10.1093/lambio/ovaf050","url":null,"abstract":"Goat milk is a superior nutritional source for human beings. It possesses probiotic, prebiotic, immunomodulatory actions and inhibits the adherence of pathogenic bacteria. The microbiota of raw goat milk is a rich source of novel bacteriocin-producing lactic acid bacteria (LAB). LAB were evaluated for their probiotic attributes, i.e. acid, bile tolerance, and safety assessment. The antimicrobial activity of LAB isolated from goat milk was assessed against the 10 most common indigenous bacterial pathogens confirmed through 16S rRNA sequencing. The strains LAB GM8 and GM121 showed high tolerance to acidic pH while GM121 showed tolerance to high bile salt concentrations. LAB GM121 showed susceptibility to eight antibiotics which meets the safety requirements regarding phenotypic resistance evaluation. Out of 10, 4 LAB GM8, GM26, GM121, GM122 displayed antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus, demonstrating their ability to produce bioactive compounds. So, based on acid, bile tolerance, and safety requirements, it can be concluded that the GM121 has the potential to be explored as probiotic strains in the dairy industry. Bacterial isolates (n-24) were screened for exopolysaccharide production and amylase activity; Bacillus paralicheniformis GM75 showed good exopolysaccharide production and antimicrobial activity while Bacillus cereus GM56 showed maximum amylase activity.","PeriodicalId":17962,"journal":{"name":"Letters in Applied Microbiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of Fe and Mn in organo-mineral-microbe interactions: evidence of carbon stabilization and transformation of organic matter leading to carbon greenhouse gas emissions. 铁和锰在有机矿物-微生物相互作用中的作用：碳稳定和有机物转化导致碳温室气体排放的证据。

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-04-01 DOI: 10.1093/lambio/ovaf044

Andrew Elohim Laloo, Abhishek Gupta, Valeria Verrone, Rama Kant Dubey

{"title":"Role of Fe and Mn in organo-mineral-microbe interactions: evidence of carbon stabilization and transformation of organic matter leading to carbon greenhouse gas emissions.","authors":"Andrew Elohim Laloo, Abhishek Gupta, Valeria Verrone, Rama Kant Dubey","doi":"10.1093/lambio/ovaf044","DOIUrl":"10.1093/lambio/ovaf044","url":null,"abstract":"Up to 90% of organic matter (OM) in soils and sediments are stabilized and protected against microbial decomposition through organo-mineral interactions, formation of soil aggregates, pH, and oxygen availability. In soils and sediment systems, OM is associated with mineral constituents promoting carbon persistence and sequestration of which iron (Fe) and manganese (Mn) are crucial components. Under anoxic condition, microbes couple the decomposition of OM to the oxidative/reductive transformation of Fe/Mn minerals leading to carbon greenhouse gas (C-GHG) emissions (i.e. CH4 and CO2). Although these organo-mineral-microbe interactions have been observed for decades, the bio-geochemical mechanisms governing the switch from OM stability toward OM degradation are not fully understood. Interest in this field have been growing steadily given the interest in global warming caused by OM decomposition leading to C-GHG emissions. This review emphasizes the dual role of Fe/Mn minerals in both OM stability and decomposition. Additionally, we synthesize the conceptual understanding of how Fe/Mn minerals govern OM dynamics and the resultant C-GHG emissions via microbial-mediated carbon transformation. We highlight the need for interdisciplinary research to better understand organo-Fe/Mn mineral-microbial interactions to develop management handles for climate mitigation strategies.","PeriodicalId":17962,"journal":{"name":"Letters in Applied Microbiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0