Short-Chain Fatty Acids and Their Role in Modulating Autoimmune Responses in Psoriasis: Insights from Recent Microbiota Research.

IF 2 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Narges Fallahi, Mitra Rafiee, Seyedeh Sindokht Hosseini, Nasrin Sereshki, Gholamreza Anani Sarab, Nafiseh Erfanian
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引用次数: 0

Abstract

Psoriasis, a chronic skin autoimmune disease characterized by abnormal immune responses, is influenced by genetic and environmental factors. Recent microbiota research has revealed that short-chain fatty acids (SCFAs), metabolites produced by gut microbiota, play a pivotal role in regulating immune function and inflammation. This review examines the current literature on the relationship between gut dysbiosis, SCFA production, and immune modulation in psoriasis, focusing on emerging evidence from microbiota and immunological studies. SCFAs have been shown to influence key immune pathways, including T-cell activation and cytokine production, which are critical in psoriasis pathogenesis. Reduced SCFA levels have been observed in psoriasis, highlighting the role of gut dysbiosis in disease progression. Understanding the gut-skin axis and the role of SCFAs offers novel insights into developing effective, safe, and accessible treatments for psoriasis. Restoring microbial balance and SCFA production may serve as a promising therapeutic approach for managing psoriasis.

短链脂肪酸及其在调节银屑病自身免疫反应中的作用:来自最近微生物群研究的见解。
牛皮癣是一种以免疫反应异常为特征的慢性皮肤自身免疫性疾病,受遗传和环境因素的影响。最近的微生物群研究表明,短链脂肪酸(SCFAs)是肠道微生物群产生的代谢物,在调节免疫功能和炎症中起着关键作用。本文回顾了目前关于牛皮癣肠道生态失调、SCFA产生和免疫调节之间关系的文献,重点关注微生物群和免疫学研究的新证据。scfa已被证明影响关键的免疫途径,包括t细胞活化和细胞因子的产生,这是银屑病发病的关键。在牛皮癣中观察到SCFA水平降低,强调了肠道生态失调在疾病进展中的作用。了解肠道-皮肤轴和scfa的作用为开发有效、安全和可及的牛皮癣治疗方法提供了新的见解。恢复微生物平衡和SCFA的产生可能是治疗牛皮癣的一种有前途的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Letters in Applied Microbiology
Letters in Applied Microbiology 工程技术-生物工程与应用微生物
CiteScore
4.40
自引率
4.20%
发文量
225
审稿时长
3.3 months
期刊介绍: Journal of & Letters in Applied Microbiology are two of the flagship research journals of the Society for Applied Microbiology (SfAM). For more than 75 years they have been publishing top quality research and reviews in the broad field of applied microbiology. The journals are provided to all SfAM members as well as having a global online readership totalling more than 500,000 downloads per year in more than 200 countries. Submitting authors can expect fast decision and publication times, averaging 33 days to first decision and 34 days from acceptance to online publication. There are no page charges.
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