Letters in Applied Microbiology最新文献

The overlooked hazard: Clostridioides difficile in preterm infants and immature immune systems-harnessing postbiotics for safer therapeutic strategies. 被忽视的危害：艰难梭菌对早产儿和未成熟免疫系统的影响——利用后生物制剂获得更安全的治疗策略。

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-07-02 DOI: 10.1093/lambio/ovaf083

Roya Abedi Soleimani, Payam Gonbari Milani, Nader Khani, Aziz Homayouni-Rad

{"title":"The overlooked hazard: Clostridioides difficile in preterm infants and immature immune systems-harnessing postbiotics for safer therapeutic strategies.","authors":"Roya Abedi Soleimani, Payam Gonbari Milani, Nader Khani, Aziz Homayouni-Rad","doi":"10.1093/lambio/ovaf083","DOIUrl":"10.1093/lambio/ovaf083","url":null,"abstract":"Clostridioides difficile is a potentially harmful bacterium that can affect preterm infants more seriously than full-term infants, largely due to their immature immune systems and underdeveloped gut microbiota. Although colonization with C. difficile is often harmless in healthy babies, preterm infants are more likely to develop infections, which can lead to serious health problems. This review looks at how an immature immune system and an imbalanced gut microbiome increase the risk of C. difficile infection (CDI) in early life. To reduce this risk, researchers are exploring postbiotics-non-living bacterial products or byproducts-as a safer alternative to traditional treatments like antibiotics. Postbiotics can help by strengthening the gut barrier, reducing inflammation, and supporting the growth of beneficial bacteria. They are also considered safe for use in vulnerable populations, including infants. This review discusses the types of postbiotics, their functions, and how they may help prevent or manage CDI. It also highlights their potential for use in infant formula as a preventative strategy. Overall, postbiotics may offer a promising new way to protect preterm infants from C. difficile and support healthier immune and gut development.","PeriodicalId":17962,"journal":{"name":"Letters in Applied Microbiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-Chain Fatty Acids and Their Role in Modulating Autoimmune Responses in Psoriasis: Insights from Recent Microbiota Research. 短链脂肪酸及其在调节银屑病自身免疫反应中的作用：来自最近微生物群研究的见解。

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-06-25 DOI: 10.1093/lambio/ovaf091

Narges Fallahi, Mitra Rafiee, Seyedeh Sindokht Hosseini, Nasrin Sereshki, Gholamreza Anani Sarab, Nafiseh Erfanian

{"title":"Short-Chain Fatty Acids and Their Role in Modulating Autoimmune Responses in Psoriasis: Insights from Recent Microbiota Research.","authors":"Narges Fallahi, Mitra Rafiee, Seyedeh Sindokht Hosseini, Nasrin Sereshki, Gholamreza Anani Sarab, Nafiseh Erfanian","doi":"10.1093/lambio/ovaf091","DOIUrl":"https://doi.org/10.1093/lambio/ovaf091","url":null,"abstract":"Psoriasis, a chronic skin autoimmune disease characterized by abnormal immune responses, is influenced by genetic and environmental factors. Recent microbiota research has revealed that short-chain fatty acids (SCFAs), metabolites produced by gut microbiota, play a pivotal role in regulating immune function and inflammation. This review examines the current literature on the relationship between gut dysbiosis, SCFA production, and immune modulation in psoriasis, focusing on emerging evidence from microbiota and immunological studies. SCFAs have been shown to influence key immune pathways, including T-cell activation and cytokine production, which are critical in psoriasis pathogenesis. Reduced SCFA levels have been observed in psoriasis, highlighting the role of gut dysbiosis in disease progression. Understanding the gut-skin axis and the role of SCFAs offers novel insights into developing effective, safe, and accessible treatments for psoriasis. Restoring microbial balance and SCFA production may serve as a promising therapeutic approach for managing psoriasis.","PeriodicalId":17962,"journal":{"name":"Letters in Applied Microbiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of inoculum composition on bacteria and bacteriophage UVC inactivation at 222 nm and 254 nm. 接种量组成对细菌和噬菌体在222 nm和254 nm灭活UVC的影响。

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-06-23 DOI: 10.1093/lambio/ovaf090

Katherine Ratliff, Michael Worth Calfee, Ahmed Abdel-Hady, Mariela Monge, Denise Aslett, Lukas Oudejans

{"title":"Impact of inoculum composition on bacteria and bacteriophage UVC inactivation at 222 nm and 254 nm.","authors":"Katherine Ratliff, Michael Worth Calfee, Ahmed Abdel-Hady, Mariela Monge, Denise Aslett, Lukas Oudejans","doi":"10.1093/lambio/ovaf090","DOIUrl":"https://doi.org/10.1093/lambio/ovaf090","url":null,"abstract":"Using technologies that emit ultraviolet-C (UVC) radiation to inactivate pathogens has gained increasing interest as a strategy for reducing the risk of disease transmission, but it can be difficult to predict their performance in applied settings. Directly irradiating occupied spaces with emerging far-UVC has been proposed, as its shorter wavelength (200-230 nm) is reportedly less damaging to human eyes and skin than longer wavelengths. In this study, we conducted surface tests to evaluate the impact of different inoculum compositions (with and without soil loads) and conditions (wet vs. dried droplets) to determine how these factors affect efficacy of UVC sources with peak emissions at 254 nm and 222 nm against five bacteria and two bacteriophages. The presence of a soil load reduced 222 nm UVC efficacy more than 254 nm, and both UVC sources were generally less effective against microbes in dried (vs. wet) inoculum. Given that pathogens will often be exposed to UVC in the presence of proteins, salts, and other constituents depending on how they are emitted, it is important to consider these challenges when quantifying efficacy.","PeriodicalId":17962,"journal":{"name":"Letters in Applied Microbiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cervical cancer pathology and vaginal and gut microbiota: conception of the association. 子宫颈癌病理与阴道和肠道微生物群：关联的概念。

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-06-18 DOI: 10.1093/lambio/ovaf088

Samaneh Mazinani, Mohammad Aghazadeh, Vahdat Poortahmasebi, Vahid Arafi, Alka Hasani

{"title":"Cervical cancer pathology and vaginal and gut microbiota: conception of the association.","authors":"Samaneh Mazinani, Mohammad Aghazadeh, Vahdat Poortahmasebi, Vahid Arafi, Alka Hasani","doi":"10.1093/lambio/ovaf088","DOIUrl":"https://doi.org/10.1093/lambio/ovaf088","url":null,"abstract":"The role of gut and vaginal microbiota has been examined as potential markers in the progression of cervical cancer and inspired heightened attention. We attempted to identify the current status, the influence of changing trends in the gut and vaginal microbiota, and their impact on cervical cancer. All publications were searched in online databases such as PubMed, Scopus, Medline, and Google Scholar using the keywords \"cervical cancer,\" \"vaginal microbiota,\" \"gut microbiota,\" \"dysbiosis,\" \"cervical intraepithelial neoplasia,\" and \"HPV.\" Growing evidence that gut microbiota dysbiosis is involved in many diseases has attracted many researchers. The vaginal microbiome is a micro-ecosystem complex that undergoes continuous fluctuations throughout a woman's life. Decrease in Lactobacilli spp. Levels can lead to an overgrowth of anaerobic bacteria, resulting in bacterial vaginosis that accounts for adverse health outcomes, including increased susceptibility to sexually transmitted infections, including human papillomavirus, and cervical intraepithelial neoplasia, leading to cervical cancer. Thus, dysbiosis, characterized by an imbalance of beneficial and harmful bacteria, can negatively affect health. Understanding the intricate interactions between the microbiota and cervical cancer can provide valuable insights into potential therapeutic strategies and the development of preventive measures.","PeriodicalId":17962,"journal":{"name":"Letters in Applied Microbiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bactericidal and anti-biofilm activity of ebastine against Staphylococcus aureus. 依巴斯汀对金黄色葡萄球菌的杀菌和抗生物膜活性。

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-06-12 DOI: 10.1093/lambio/ovaf086

Liping Zhao, Hui Zhang, Li Zha, Xicheng Zhou, Meng Yang

{"title":"Bactericidal and anti-biofilm activity of ebastine against Staphylococcus aureus.","authors":"Liping Zhao, Hui Zhang, Li Zha, Xicheng Zhou, Meng Yang","doi":"10.1093/lambio/ovaf086","DOIUrl":"https://doi.org/10.1093/lambio/ovaf086","url":null,"abstract":"Drug repurposing, offers promising opportunities to address infections caused by multidrug-resistant bacteria. This study was to evaluate the bactericidal activity, anti-biofilm properties, and potential mechanisms of the antihistamine drug ebastine against S. aureus. The minimum inhibitory concentrations of ebastine against standard and clinical S. aureus isolates were determined using the broth microdilution method. The MIC values ranged from 2 to 8 µg·mL-1, indicating good activity against clinical drug-resistant strains. Time-kill curve analyses revealed a dose-dependent bactericidal effect. Regarding anti-biofilm activity, ebastine significantly inhibited biofilm formation at higher concentrations and demonstrated a moderate ability to eradicate preformed biofilms. Mechanistic studies revealed that ebastine exerted the antimicrobial effects by causing disruption to bacterial membrane integrity and inducing reactive oxygen species generation. Furthermore, safety evaluations showed that ebastine exhibited limited toxicity to mammalian cells, with negligible hemolytic effects and good overall safety profiles. This study provided new insights into the potential applications of ebastine in the field of antimicrobial therapy, highlighting its promise as a non-traditional antibacterial agent.","PeriodicalId":17962,"journal":{"name":"Letters in Applied Microbiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of a bacterial lysate on composition of the lung microbiota in a mouse model of asthma exposed to titanium dioxide as one of air pollutants. 细菌裂解物对暴露于二氧化钛作为空气污染物之一的哮喘小鼠模型中肺微生物群组成的影响。

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-06-02 DOI: 10.1093/lambio/ovaf089

Da-Yeon Hwang, Min-Hyeok An, Pureun-Haneul Lee, Ae-Rin Baek, Shinhee Park, Yunha Nam, June-Hyuk Lee, Sung-Woo Park, Do-Jin Kim, An-Soo Jang

{"title":"The impact of a bacterial lysate on composition of the lung microbiota in a mouse model of asthma exposed to titanium dioxide as one of air pollutants.","authors":"Da-Yeon Hwang, Min-Hyeok An, Pureun-Haneul Lee, Ae-Rin Baek, Shinhee Park, Yunha Nam, June-Hyuk Lee, Sung-Woo Park, Do-Jin Kim, An-Soo Jang","doi":"10.1093/lambio/ovaf089","DOIUrl":"https://doi.org/10.1093/lambio/ovaf089","url":null,"abstract":"Environmental microbes have been linked to both beneficial and harmful effects on the lungs in relation to asthma. The aim of our study was to characterize the bacterial microbiome in lung samples from a mouse model of asthma exposed to titanium dioxide (TiO2) particles, and the effect of OM-85 Broncho-Vaxom®, a bacterial lysate on lung microbiome in mice. The mice were divided randomly into four groups of 6-8 mice per group. To identify the microbial communities in lung samples the upper right lung of all groups, we amplified and sequenced the rRNA gene regions from bacterial DNA (16S). The amplified 16S region was sequenced using the Roche-454 Life Sciences Titanium pyrosequencing platform. In the OVA + TiO2 + OM-85 group, airway hyperresponsiveness and inflammatory cells in bronchoalveolar lavage fluid (BALF) decreased compared to the OVA + TiO2 group. Inflammatory cytokine levels were lower in the OVA + TiO2 + OM-85 group. Certain bacteria, and Collinsella aerofaciens, decreased in the OVA + TiO2 + OM-85 group, while Neisseria perflava and Fusobacterium periodonticum increased. Lactic acid bacteria groups decreased in the OVA + TiO2 + OM-85 group. TiO2 particles exposure changed lung microbial taxa, and modified by a bacterial lysate, suggesting that a probiotic can be helpful in reducing exacerbation of airway disease exposed to air pollutants.","PeriodicalId":17962,"journal":{"name":"Letters in Applied Microbiology","volume":"78 6","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are foliar extracts of mycorrhizal Hymenaea martiana toxic to human peripheral blood mononuclear cells? 菌根膜菌叶提取物对人外周血单核细胞有毒性吗？

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-06-02 DOI: 10.1093/lambio/ovaf075

Brena Coutinho Muniz, Carlos André Ribeiro Costa, Caio Bezerra Barreto, Jefferlone Lopes da Silva Filho, Maria Rafaele Oliveira Bezerra da Silva, Silvana de Fátima Ferreira da Silva, Daniela de Araújo Viana Marques, Qiang-Sheng Wu, Fábio Sérgio Barbosa da Silva

{"title":"Are foliar extracts of mycorrhizal Hymenaea martiana toxic to human peripheral blood mononuclear cells?","authors":"Brena Coutinho Muniz, Carlos André Ribeiro Costa, Caio Bezerra Barreto, Jefferlone Lopes da Silva Filho, Maria Rafaele Oliveira Bezerra da Silva, Silvana de Fátima Ferreira da Silva, Daniela de Araújo Viana Marques, Qiang-Sheng Wu, Fábio Sérgio Barbosa da Silva","doi":"10.1093/lambio/ovaf075","DOIUrl":"10.1093/lambio/ovaf075","url":null,"abstract":"Arbuscular mycorrhizal fungi (AMF) are known to enhance the accumulation of bioactive compounds with medicinal properties in plants. However, the potential cytotoxic effects of extracts from mycorrhizal plants on peripheral blood mononuclear cells (PBMC) remain unexplored. Therefore, this study aimed to verify the cytotoxic potential of foliar extract from Hymenaea martiana Hayne seedlings, either associated or not associated with AMF on PBMC. A greenhouse experiment was conducted with two treatments: a control group (without AMF) and a group inoculated with Acaulospora longula Spain and N.C. Schenck. After 148 days, leaves were collected to prepare aqueous extracts, and cytotoxicity of the extracts was assessed using the MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) assay. Additionally, the antioxidant potential and the content of soluble carbohydrates, flavonoids, flavonols, flavonones, dihydroflavonols, and saponins were assessed. Hymenaea martiana seedlings associated with A. longula exhibited a more than 50% increase in the accumulation of phenolic compounds compared to the control. However, no toxicity was detected for PBMC under any of the conditions evaluated. This study provides the first evidence of the effect of mycorrhizal plant extracts on human blood cells, highlighting their potential safety for medicinal and cosmetic applications.","PeriodicalId":17962,"journal":{"name":"Letters in Applied Microbiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The dual role of Bacillus thuringiensis RZ2MS9: its effectiveness as an entomopathogen and a plant growth promoter in vitro and in field conditions. 苏云金芽孢杆菌RZ2MS9在体外和田间条件下的双重作用：昆虫病原和植物生长促进剂。

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-06-02 DOI: 10.1093/lambio/ovaf076

Daniel Prezotto Longatto, Adriana Sturion Lorenzi, Helena Gutierrez Oliveira, Mauricio Santos Rosa, Joelma Marcon, João Lucio Azevedo, Maria Carolina Quecine

{"title":"The dual role of Bacillus thuringiensis RZ2MS9: its effectiveness as an entomopathogen and a plant growth promoter in vitro and in field conditions.","authors":"Daniel Prezotto Longatto, Adriana Sturion Lorenzi, Helena Gutierrez Oliveira, Mauricio Santos Rosa, Joelma Marcon, João Lucio Azevedo, Maria Carolina Quecine","doi":"10.1093/lambio/ovaf076","DOIUrl":"10.1093/lambio/ovaf076","url":null,"abstract":"Bacillus thuringiensis RZ2MS9, a plant growth-promoting rhizobacterium isolated from the rhizosphere of guarana plants, has shown significant growth enhancement in both soybean and maize crops. To explore its full potential, we investigated RZ2MS9's entomopathogenic properties against Lepidoptera and Coleoptera larvae in vitro, and against Hemiptera populations in both in vitro and field conditions. The strain was evaluated for insecticidal crystal proteins, which were found in cuboid and spherical forms. Comparative genomic analysis revealed that while RZ2MS9 did not share significant pesticidal protein genes with B. thuringiensis HD1, it has unique genes related to plant growth promotion and nutrient acquisition. RZ2MS9 also exhibited chitinolytic activity, linked to the presence of the chitosanase coding gene (chP). Under laboratory conditions, the larvae mortality under RZ2MS9 treatment was 90% for sugarcane borer (Diatraea saccharalis), 92.5% for old-world cotton bollworm (Helicoverpa armigera), 30% for Agrotis ipsilon, and 87.5% for Anthonomus grandis. In addition, RZ2MS9 caused severe wing deformities in 40% of Spodoptera frugiperda moths and repelled Piezodorus guildinii from its food source. In field trials, soybean plants inoculated with RZ2MS9 exhibited significative increased length. P. guildinii was more prevalent in the inoculated plants, while the incidence of Euchistus heros remained unchanged.","PeriodicalId":17962,"journal":{"name":"Letters in Applied Microbiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144111257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Singlet oxygen antioxidant capacity of carotenoids from Halorubrum salinarum. 盐碱地类胡萝卜素单线态氧抗氧化能力研究。

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-06-02 DOI: 10.1093/lambio/ovaf085

Nestly Anne M Cruz-Angeles, Mark Kevin P Devanadera, Kenshi Watanabe, Reuel M Bennett, Tsunehiro Aki, Gina R Dedeles

引用次数: 0

In vitro and in-planta bioefficacy of bacteriome isolated from diseased leaf lesions of two contrasting rice genotypes against sheath blight disease of rice. 两种不同基因型水稻叶片病变菌群对水稻纹枯病的体外和体内生物药效研究

IF 2 4区生物学

Letters in Applied Microbiology Pub Date : 2025-06-02 DOI: 10.1093/lambio/ovaf078

Indrajeet Usha, Devanna Pramesh, Adke Raghunandana, Muthakapalli Krishnareddy Prasannakumar, Gururaj Sunkad, Channappa Manjunatha

{"title":"In vitro and in-planta bioefficacy of bacteriome isolated from diseased leaf lesions of two contrasting rice genotypes against sheath blight disease of rice.","authors":"Indrajeet Usha, Devanna Pramesh, Adke Raghunandana, Muthakapalli Krishnareddy Prasannakumar, Gururaj Sunkad, Channappa Manjunatha","doi":"10.1093/lambio/ovaf078","DOIUrl":"10.1093/lambio/ovaf078","url":null,"abstract":"Rice leaves harbor a diverse agriculturally important bacteriome. Using different dilutions and media, 20 bacterial isolates were obtained from the diseased and healthy leaves of two rice cultivars (cv. BPT-5204 and cv. Tetep). Later, the taxonomy was deduced based on the 16S rDNA sequences, which revealed 17 bacterial species belonging to 13 genera. The antifungal activity of 17 bacteria was tested against Rhizoctonia solani, which showed that Bacillus cereus, Stenotrophomonas maltophilia, and Acinetobacter lwoffii exhibited the mycelial inhibition of 65.18%, 61.85%, and 61.85%, respectively. Further, six selected bacteria (treatments: T1-T6) in three different methods of inoculation (methods: M1-M3) were tested on-field against sheath blight (ShB) for two consecutive Kharif seasons (2022 and 2023). The two-season data indicated a statistically insignificant effect of methods on the % disease index (PDI) (40.51-42.47), whereas different bacteria treatments (T1-T6) showed a significant impact on PDI (29.15-52.08). S. maltophilia isolated from the diseased BPT-5204 was superior to all other strains in reducing the PDI (29.15). We successfully isolated and functionally characterized 17 bacteria from the artificially diseased contrasting genotypes. This study demonstrated that rice lesions naturally harbor a diverse bacterium with antifungal effects that can be used to develop non-chemical-based disease management strategies.","PeriodicalId":17962,"journal":{"name":"Letters in Applied Microbiology","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0