Journal of Traditional and Complementary Medicine最新文献

{"title":"Mulberry leaf extract inhibits obesity and protects against diethylnitrosamine-induced hepatocellular carcinoma in rats","authors":"Yun-Ching Chang ,&nbsp;Meng-Hsun Yu ,&nbsp;Hui-Pei Huang ,&nbsp;Dong-Hui Chen ,&nbsp;Mon-Yuan Yang ,&nbsp;Chau-Jong Wang","doi":"10.1016/j.jtcme.2024.01.007","DOIUrl":"10.1016/j.jtcme.2024.01.007","url":null,"abstract":"<div><p>Mulberry leaf has been recognized as a traditional Chinese medicinal plant, which was distributed throughout the Asia. The aqueous extract of mulberry leaf extract (MLE) has various biologically active components such as polyphenols and flavonoids. However, the inhibitory effect of MLE in hepatocarcinogenesis is poorly understood. In this study, we determined the role of MLE supplementation in preventing hepatocarcinogenesis in a carcinogen-initiated high-fat diet (HFD)-promoted Sprague-Dawley (SD) rat model. The rats were fed an HFD to induce obesity and spontaneous hepatomas by administering 0.01% diethylnitrosamine (DEN) in their drinking water for 12 weeks (HD group), and also to fed MLE through oral ingestion at daily doses of 0.5%, 1%, or 2%. At the end of the 12-week experimental period, the liver tumors were analyzed to identify markers of oxidative stress and antioxidant enzyme activities, and their serum was analyzed to determine their nutritional status and liver function. Histopathological analysis revealed that MLE supplementation significantly suppressed the severity and incidence of hepatic tumors. Furthermore, compared with the HFD + DEN groups, the expression of protein kinase C (PKC)-α and Rac family small GTPase 1 (Rac1) was lower in the MLE groups. These findings suggest that MLE prevents obesity-enhanced, carcinogen-induced hepatocellular carcinoma development, potentially through the protein kinase C (PKC)α/Rac1 signaling pathway. MLE might be an effective chemoprevention modality for nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH)-related hepatocarcinogenesis.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 3","pages":"Pages 266-275"},"PeriodicalIF":4.5,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411024000075/pdfft?md5=263666bb48fdb3aa146228c5fb152be9&pid=1-s2.0-S2225411024000075-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139640128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural 7,8-secolignans from Schisandra sphenanthera fruit potently inhibit SARS-CoV-2 3CLpro and inflammation","authors":"","doi":"10.1016/j.jtcme.2024.01.005","DOIUrl":"10.1016/j.jtcme.2024.01.005","url":null,"abstract":"<div><p>The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), turned into a global pandemic, and there remains an urgent demand for specific/targeted drugs for the disease. The 3C-like protease (3CL^pro) is a promising target for developing anti-coronavirus drugs. <em>Schisandra sphenanthera</em> fruit is a well-known traditional Chinese medicine (TCM) with good antiviral activity. This study found that the ethanolic extract displayed a significant inhibitory effect against SARS-CoV-2 3CL^pro. Forty-four compounds were identified in this extract using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS). Combining molecular docking and <em>in vitro</em> experiments, we found that two epimeric 7,8-secolignans, rel-(1<em>S</em>,2<em>R</em>)-1-(3,4-dimethoxyphenyl)-2-methyl-3-oxobutyl-3,4-dimethoxybenzoate (<strong>2</strong>) and rel-(1<em>S</em>,2<em>S</em>)-1-(3,4-dimethoxyphenyl)-2-methyl-3-oxobutyl-3,4-dimethoxybenzoate (<strong>4)</strong>, potently inhibited 3CL^pro with IC₅₀ values of 4.88 ± 0.60 μM and 4.75 ± 0.34 μM, respectively. Moreover, <em>in vivo</em> and <em>in vitro</em> experiments indicated that compounds <strong>2</strong> and <strong>4</strong> were potent in regulating the inflammatory response and preventing lung injury. Our findings indicate that compounds <strong>2</strong> and <strong>4</strong> may emerge as promising SARS-CoV-2 inhibitors via 3CL^pro inhibition and anti-inflammatory mechanisms.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 5","pages":"Pages 501-509"},"PeriodicalIF":3.3,"publicationDate":"2024-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411024000051/pdfft?md5=914963c5062bc3674328c441064b5621&pid=1-s2.0-S2225411024000051-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139539070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular study of the KCNJ11 gene and its correlation with Prakriti to preventing and managing type 2 diabetes","authors":"","doi":"10.1016/j.jtcme.2024.01.004","DOIUrl":"10.1016/j.jtcme.2024.01.004","url":null,"abstract":"<div><p>In Ayurveda, every individual is believed to possess a unique entity known as <em>Prakriti,</em> which distinguishes them from others physically, physiologically, and psychologically. This entity also determines an individual's response to a particular stimulus, and it is believed that such responses are not solely determined by genetics. The present research aims to validate the Ayurvedic concept of <em>Prakriti</em> from a modern molecular perspective to strengthen the personalized and precise treatment approach. A study was conducted to investigate the role of the KCNJ11gene in the susceptibility of individuals to type 2 diabetes mellitus (T2DM) with their metabolic status. The research involved allele mining on three major <em>Prakriti</em> groups - <em>Vata, Pitta</em>, and <em>Kapha -</em> in 112 patients with T2DM and 112 healthy individuals. The KCNJ11 gene, responsible for insulin secretion membrane pore formation, was analyzed to determine the susceptibility of different <em>Prakriti</em> types to T2DM. The MutPred tool predicted the molecular cause of disease-related amino acid substitution. According to the study, only <em>Pitta</em> and <em>Kapha Prakriti</em> were diagnosed with diabetes, while all three <em>Prakriti</em> types were present in the control group of healthy individuals. A protein model was prepared, and the changes resulting from mutations were observed for each group in their protein sequence, both as synonymous and non-synonymous mutations. Ultimately, these changes contributed to the manifestation of T2DM. Based on the findings, it appears that <em>Prakriti</em> groups may experience changes in protein function due to nonsynonymous mutations and differences in amino acids at the protein level.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 5","pages":"Pages 494-500"},"PeriodicalIF":3.3,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S222541102400004X/pdfft?md5=ff2558027762bc3465f9e76e0fb66b99&pid=1-s2.0-S222541102400004X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140523385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin in treatment of hematological cancers: Promises and challenges","authors":"Maliheh Entezari ,&nbsp;Armita Tayari ,&nbsp;Mahshid Deldar Abad Paskeh ,&nbsp;Simin Khorsand Kheirabad ,&nbsp;Sahar Naeemi ,&nbsp;Afshin Taheriazam ,&nbsp;Hossein Dehghani ,&nbsp;Shokooh Salimimoghadam ,&nbsp;Mehrdad Hashemi ,&nbsp;Sepideh Mirzaei ,&nbsp;Saeed Samarghandian","doi":"10.1016/j.jtcme.2023.10.004","DOIUrl":"10.1016/j.jtcme.2023.10.004","url":null,"abstract":"<div><p>Hematological cancers include leukemia, myeloma and lymphoma and up to 178.000 new cases are diagnosed with these tumors each year. Different kinds of treatment including radiotherapy, chemotherapy, immunotherapy and stem cell transplantation have been employed in the therapy of hematological cancers. However, they are still causing death among patients. On the other hand, curcumin as an anti-cancer agent for the suppression of human cancers has been introduced. The treatment of hematological cancers using curcumin has been followed. Curcumin diminishes viability and survival rate of leukemia, myeloma and lymphoma cells. Curcumin stimulates apoptosis and G2/M arrest to impair progression of tumor. Curcumin decreases levels of matrix metalloproteinases in suppressing cancer metastasis. A number of downstream targets including VEGF, Akt and STAT3 undergo suppression by curcumin in suppressing progression of hematological cancers. Curcumin stimulates DNA damage and reduces resistance of cancer cells to irradiation. Furthermore, curcumin causes drug sensitivity of hematological tumors, especially myeloma. For targeted delivery of curcumin and improving its pharmacokinetic and anti-cancer features, nanostructures containing curcumin and other anti-cancer agents have been developed.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 2","pages":"Pages 121-134"},"PeriodicalIF":4.5,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411023001116/pdfft?md5=36b06bea4a56b44b2e924690885ea89c&pid=1-s2.0-S2225411023001116-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139392481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico anti-viral assessment of phytoconstituents in a traditional (Siddha Medicine) polyherbal formulation – Targeting Mpro and pan-coronavirus post-fusion Spike protein","authors":"Sumit Kumar Mandal ,&nbsp;MD Muzaffar-Ur Rehman ,&nbsp;Ashish Katyal ,&nbsp;Kanishk Rajvanshi ,&nbsp;Manoj Kannan ,&nbsp;Mohit Garg ,&nbsp;Sankaranarayanan Murugesan ,&nbsp;P.R. Deepa","doi":"10.1016/j.jtcme.2023.07.004","DOIUrl":"10.1016/j.jtcme.2023.07.004","url":null,"abstract":"<div><h3>Background and aim</h3><p>Novel nature of the viral pathogen SARS-CoV-2 and the absence of standard drugs for treatment, have been a major challenge to combat this deadly infection. Natural products offer safe and effective remedy, for which traditional ethnic medicine can provide leads. An indigenous poly-herbal formulation, Kabasura Kudineer from Siddha system of medicine was evaluated here using a combination of computational approaches, to identify potential inhibitors against two anti-SARS-CoV-2 targets – post-fusion Spike protein (structural protein) and main protease (Mpro, non-structural protein).</p></div><div><h3>Experimental procedure</h3><p>We docked 32 phytochemicals from the poly-herbal formulation against viral post-fusion Spike glycoprotein and Mpro followed by molecular dynamics using Schrodinger software. Drug-likeness analysis was performed using machine learning (ML) approach and pkCSM.</p></div><div><h3>Results</h3><p>The binding affinity of the phytochemicals in Kabasura Kudineer revealed the following top-five bioactives: Quercetin &gt; Luteolin &gt; Chrysoeriol &gt; 5-Hydroxy-7,8-Dimethoxyflavone &gt; Scutellarein against Mpro target, and Gallic acid &gt; Piperlonguminine &gt; Chrysoeriol &gt; Elemol &gt; Piperine against post-fusion Spike protein target. Quercetin and Gallic acid exhibited binding stability in complexation with their respective viral-targets and favourable free energy change as revealed by the molecular dynamics simulations and MM-PBSA analysis. <em>In silico</em> predicted pharmacokinetic profiling of these ligands revealed appropriate drug-likeness properties.</p></div><div><h3>Conclusion</h3><p>These outcomes provide: (a) potential mechanism for the anti-viral efficacy of the indigenous Siddha formulation, targeting Mpro and post-fusion Spike protein (b) top bioactive lead-molecules that may be developed as natural product-based anti-viral pharmacotherapy and their pleiotropic protective effects may be leveraged to manage co-morbidities associated with COVID-19.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 1","pages":"Pages 55-69"},"PeriodicalIF":4.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411023000809/pdfft?md5=b2b56e439f1e7184f71e102a2a8580e4&pid=1-s2.0-S2225411023000809-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46287800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative traditional Chinese medicine treatment for children with obstructive sleep apnea","authors":"Wan-Yu Lai ,&nbsp;Chang-Ching Wei ,&nbsp;Chien-Heng Lin ,&nbsp;Liang- Wen Hang ,&nbsp;Ying-Hsiu Shih ,&nbsp;Fen-Wei Huang ,&nbsp;Hung-Rong Yen","doi":"10.1016/j.jtcme.2023.08.002","DOIUrl":"10.1016/j.jtcme.2023.08.002","url":null,"abstract":"<div><h3>Purpose</h3><p>Obstructive sleep apnea (OSA) is a chronic disease that affects 1%–6% of children. Our study aims to explore the effectiveness and clinical characteristics of integrative Traditional Chinese Medicine (ITCM) for pediatric OSA.</p></div><div><h3>Materials and methods</h3><p>In this retrospective cohort study, we assessed differences of polysomnography (PSG) parameters and clinical characteristics between 2009 and 2020. Children &lt;12 years old diagnosed with OSA (n = 508) were included and were categorized into ITCM cohort, western medicine (WM) cohort ,and surgery cohort. Outcomes were apnea-hypopnea index (AHI), respiratory disturbance index (RDI), and body mass index (BMI).</p></div><div><h3>Results</h3><p>There were 56 (11%), 324 (63.8%), and 128 (25.2%) patients in the ITCM, WM, and surgery cohorts. Among 17, 26, and 33 patients in the ITCM, WM, and surgery cohorts underwent follow-up PSG studies, respectively. In the ITCM follow-up cohort, AHI were significantly reduced (9.59 to 5.71, p &lt; 0.05). BMI significantly increased in the WM follow-up cohort (19.46 to 20.50, p &lt; 0.05) and the surgery follow-up cohort (18.04 to 18.85, p &lt; 0.01). Comparing ITCM to WM cohort, a significant difference was found between the changes in RDI (ITCM: −6.78, WM: 0.51, p &lt; 0.05) after treatment. Among ITCM follow-up cohort, the most prescribed TCM formula was Forsythia and Laminaria Combination. The most prescribed TCM herb was Ephedrae Herba.</p></div><div><h3>Conclusions</h3><p>ITCM therapy can significantly reduce RDI and control BMI. We identified potential TCM treatments for pediatric OSA. Further study of the pharmacological mechanisms and clinical efficacy is warranted.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 1","pages":"Pages 109-120"},"PeriodicalIF":4.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411023000858/pdfft?md5=f7a182db60c7fd7bcfeba8bd506e2e94&pid=1-s2.0-S2225411023000858-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42386999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zhilong Huoxue Tongyu capsule alleviates myocardial fibrosis by improving endothelial cell dysfunction","authors":"Tao Bi ,&nbsp;Yanan Zhou ,&nbsp;Linshen Mao ,&nbsp;Pan Liang ,&nbsp;Jiali Liu ,&nbsp;Luyin Yang ,&nbsp;Guilin Ren ,&nbsp;Maryam Mazhar ,&nbsp;Hongping Shen ,&nbsp;Ping Liu ,&nbsp;Roman Spáčil ,&nbsp;Qing Guo ,&nbsp;Gang Luo ,&nbsp;Sijin Yang ,&nbsp;Wei Ren","doi":"10.1016/j.jtcme.2023.07.001","DOIUrl":"10.1016/j.jtcme.2023.07.001","url":null,"abstract":"<div><h3>Background and aim</h3><p>Zhilong Huoxue Tongyu (ZL) capsule is a classical traditional Chinese medicine (TCM) with satisfactory curative effects. Endothelial cell (EC) dysfunction plays an important role during myocardial fibrosis (MF). But the therapeutic effect of ZL capsule on EC dysfunction remains unknown in the development of MF. This study aims to investigate the effect of ZL capsule on EC dysfunction during MF <em>in vivo</em>.</p></div><div><h3>Experimental procedure</h3><p>The model of MF is established <em>in vivo</em> by injecting isoproterenol for 14 days, simultaneously, we examined the therapeutic effect of ZL capsule on MF <em>in vivo</em>. An integrative approach combining biomarker examination, echocardiography and myocardial fibrosis condition using Hematoxylin-eosin staining, Masson staining, and Sirius red staining were performed to assess the efficacy of ZL capsule against MF. Subsequently, comprehensive immunofluorescence staining was performed to evaluate the therapeutic effect of ZL capsule on EC dysfunction.</p></div><div><h3>Results and conclusion</h3><p>Prior to experiments, analysis of the published single-cell sequencing data was performed and it was discovered that EC dysfunction plays an important role. Further pharmacological results showed that ZL capsule could alleviate fibrosis injury and collagen fiber deposition. The mechanism investigation results showed that the endothelial-to-mesenchymal transition (EndMT) and MHC class-II (MHC-II) expression in EC were improved. In addition, ZL capsule can attenuate the inflammatory response during MF by intervening the activation of CD4⁺T cell mediated by EC. For the first time, we provided evidence that ZL capsule could improve MF by alleviating EC dysfunction via the regulation of EndMT and expression of MHC-II.</p></div><div><h3>Taxonomy (classification by evise)</h3><p>Myocardial fibrosis, Chinese Herbal Medicine, Traditional Medicine, Endothelium, dysfunction, Endothelial-to-mesenchymal transition.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 1","pages":"Pages 40-54"},"PeriodicalIF":4.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411023000767/pdfft?md5=bf9f9f9739dc0336dec8ea2eb8c47af3&pid=1-s2.0-S2225411023000767-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49142563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boswellic acid formulations are not suitable for treatment of pediatric high-grade glioma due to tumor promoting potential","authors":"Maria Wiese ,&nbsp;Bente Pohlmeier ,&nbsp;Klaudia Kubiak ,&nbsp;Fatma E. El-Khouly ,&nbsp;Maren Sitte ,&nbsp;Angel M. Carcaboso ,&nbsp;Joshua N. Baugh ,&nbsp;Thomas Perwein ,&nbsp;Gunther Nussbaumer ,&nbsp;Michael Karremann ,&nbsp;Gerrit H. Gielen ,&nbsp;Gabriela Salinas ,&nbsp;Christof M. Kramm","doi":"10.1016/j.jtcme.2023.07.007","DOIUrl":"10.1016/j.jtcme.2023.07.007","url":null,"abstract":"<div><h3>Background and aim</h3><p>Pediatric high-grade gliomas (pedHGG) comprise a very poor prognosis. Thus, parents of affected children are increasingly resorting to complementary and alternative medicine (CAM), among those Boswellia extracts. However, nothing is known about the therapeutic effectiveness of their active substances, Boswellic acids (BA) in pedHGG. Thus, we aimed to investigate if the three main Boswellic acids (BA) present in Boswellia plants, alpha-boswellic acid (α-BA), beta-boswellic acid (β-BA) and 3-acetyl-11-keto-beta-boswellic acid (AKBA) hold any promising potential for treatment of affected pedHGG patients.</p></div><div><h3>Experimental procedure</h3><p>Histone 3 (H3)-wildtype and H3.3K27M-mutant pedHGG cell lines were treated with BA, either alone or in combination with radio-chemotherapy with temozolomide. Cell viability, stemness properties, apoptosis, <em>in ovo</em> tumor growth and the transcriptome was investigated upon BA treatment.</p></div><div><h3>Results and conclusion</h3><p>Interestingly, α-BA and β-BA treatment promoted certain tumor properties in both pedHGG cells. AKBA treatment reduced cell viability and colony growth accompanied by induction of slight anti-inflammatory effects especially in H3.3K27M-mutant pedHGG cells. However, no effects on apoptosis and in ovo tumor growth were found. In conclusion, besides positive anti-tumor effects of AKBA, tumor promoting effects were observed upon treatment with α-BA and β-BA. Thus, only pure AKBA formulations may be used to exploit any potential positive effects in pedHGG patients. In conclusion, the use of commercially available supplements with a mixture of different BA cannot be recommended due to detrimental effects of certain BA whereas pure AKBA formulations might hold some potential as therapeutic supplement for treatment of pedHGG patients.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 1","pages":"Pages 101-108"},"PeriodicalIF":4.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411023000822/pdfft?md5=05c514f2d5989c0ef6e0fbf44e63ccf9&pid=1-s2.0-S2225411023000822-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49428929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-derived natural medicines for the management of osteoporosis: A comprehensive review of clinical trials","authors":"Seyedeh Mahnaz Karimi ,&nbsp;Mohammad Bayat ,&nbsp;Roja Rahimi","doi":"10.1016/j.jtcme.2023.08.001","DOIUrl":"10.1016/j.jtcme.2023.08.001","url":null,"abstract":"<div><h3>Background</h3><p>Osteoporosis is a chronic and systemic skeletal disease that is defined by low bone mineral density (BMD) along with an increase in bone fragility and susceptibility to fracture. This study aimed to overview clinical evidence on the use of herbal medicine for management of osteoporosis.</p></div><div><h3>Methods</h3><p>Electronic databases including Pubmed, Medline, Cochrane library, and Scopus were searched until November 2022 for any clinical studies on the efficacy and/or safety of plant-derived medicines in the management of osteoporosis.</p></div><div><h3>Results</h3><p>The search yielded 57 results: 19 on single herbs, 16 on multi-component herbal preparations, and 22 on plant-derived secondary metabolites. Risk of fracture, bone alkaline phosphatase, BMD, and specific bone biomarkers are investigated outcomes in these studies. Medicinal plants including <em>Acanthopanax senticosus, Actaea racemosa, Allium cepa, Asparagus racemosus, Camellia sinensis, Cissus quadrangularis, Cornus mas, Nigella sativa, Olea europaea, Opuntia ficus-indica, Pinus pinaster, Trifolium pretense</em> and phytochemicals including isoflavones, ginsenoside, Epimedium prenyl flavonoids, tocotrienols are among plant-derived medicines clinically investigated on osteoporosis. It seems that multi-component herbal preparations were more effective than single-component ones; because of the synergistic effects of their constituents. The investigated herbal medicines demonstrated their promising results in osteoporosis via targeting different pathways in bone metabolism, including balancing osteoblasts and osteoclasts, anti-inflammatory, immunomodulatory, antioxidant, and estrogen-like functions.</p></div><div><h3>Conclusion</h3><p>It seems that plant-derived medicines have beneficial effects on bone and may manage osteoporosis by affecting different targets and pathways involved in osteoporosis; However, Future studies are needed to confirm the effectiveness and safety of these preparations.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 1","pages":"Pages 1-18"},"PeriodicalIF":4.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411023000846/pdfft?md5=86b398c02d1fe496ffcb183acd0f1b76&pid=1-s2.0-S2225411023000846-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42362207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response surface methodology based development of an optimized polyherbal formulation and evaluation of its anti-diabetic and anti-obesity potential in high-fat diet-induced obese mice","authors":"Tanisha,&nbsp;Sunil Venkategowda,&nbsp;Mala Majumdar","doi":"10.1016/j.jtcme.2023.07.002","DOIUrl":"10.1016/j.jtcme.2023.07.002","url":null,"abstract":"<div><h3>Background and aim</h3><p>The seeds of <em>Nelumbo nucifera, Chenopodium quinoa</em> and <em>Salvia hispanica</em> are known as super foods due to their various therapeutic properties. The present study aimed to develop an optimized polyherbal formulation from edible seeds aqueous extract and to evaluate its anti-diabetic and lipase inhibitory effect on diet-induced obese diabetic mice.</p></div><div><h3>Experimental procedure</h3><p>Response surface methodology based various formulations were evaluated for their potent anti-diabetic, lipase-inhibitory and antioxidant activities. Acute toxicity of the best optimized formulation was conducted. The mice were fed a high fat diet for 10 weeks resulting in hyperglycemia and obesity. Oral tolerance tests (sucrose, starch and lipid) of the formulation were performed. The mice were supplemented with different doses (125, 250 and 500 mg/kg) of the formulation for 6 weeks. The body weight and blood glucose level were monitored on a weekly basis. Finally, histological alterations and lipid profiles were analysed.</p></div><div><h3>Results and conclusion</h3><p>The formulation containing equal concentration (1.5 mg/ml) of each seed extract showed maximum bioactivities. The formulation was found to be safe during toxicity assay. The tolerance tests supported the anti-diabetic and anti-obesity effect. Higher dose (500 mg/kg) of the formulation significantly (<em>p &lt;</em> 0.01) lowered elevated fasting blood glucose, lipid indices and ameliorated the histological alterations in liver, kidney and pancreas caused by high fat diet. We demonstrated for the first time that the developed aqueous extract optimized formulation possess anti-diabetic and anti-obesity potential and thus could be used as adjuvant therapy for holistic management of type 2 diabetes mellitus.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 1","pages":"Pages 70-81"},"PeriodicalIF":4.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411023000779/pdfft?md5=0e8cfa4fc1ae3b20f7e40bb6763aff85&pid=1-s2.0-S2225411023000779-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43915318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}