Journal of Traditional and Complementary Medicine最新文献

{"title":"Therapeutic efficacy of jeoryeong-tang in dextran sulfate sodium-induced mouse model of inflammatory bowel disease.","authors":"Il-Woong Jang, Seung Mok Ryu, Do-Hyun Kim, Sun-Young Hwang, Kwanhwan Wi, Soong-In Lee, Mee-Hyun Lee","doi":"10.1016/j.jtcme.2024.11.018","DOIUrl":"10.1016/j.jtcme.2024.11.018","url":null,"abstract":"<p><strong>Background: </strong>Jeoryeong-tang (JRT) was first recorded in <i>Shanghanlun</i>. It is composed of Polyporus Sclerotium, Poria, Asini Corii Colla, Alisma Rhizome, and Talcum at the same weight ratio. These medicinal materials are known for diuretic and hemostatic effects and have been traditionally used to treat kidney and bladder diseases. However, their potential therapeutic effects on colon diseases, particularly inflammatory bowel disease (IBD), have not been extensively studied. Therefore, this study aimed to investigate the therapeutic efficacy of JRT in IBD and explore its underlying anti-inflammatory mechanisms using a murine model of colitis induced by dextran sulfate sodium (DSS).</p><p><strong>Methods: </strong>Mice were treated with 3.0 % or 2.5 % DSS for 6 days to induce colitis and JRT extract was then administered at a low level of 40 mg/kg (JRT-L), a medium level of 120 mg/kg (JRT-M), or a high level of 400 mg/kg (JRT-H) once a day. During the administration period, clinical disease activity index (DAI) reflecting survival rate, diarrhea, bloody stool, and weight loss rate was evaluated. The degree of colonic tissue damage was scored and evaluated through hematoxylin and eosin staining. Cyclooxygenase-2 (COX-2), p-STAT3 and p-ERK expression were examined with immunohistochemistry. Tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and -1β levels were analyzed using a cytokine enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>Among mice treated with 3.0 % DSS, JRT-M significantly improved the survival rate compared to other treatments as a result of observation for a total of 14 days. While, in the 2.5 % DSS-treated model, the average body weights of mice in both of JRT-M and JRT-H groups were significantly higher than that in the DSS group. In addition, the JRT-M group showed significantly lower DAI score than that in the DSS group. As a result of evaluating the extent of colon tissue damage, JRT-M and JRT-H groups both showed significantly lower inflammatory index and thinner muscular externa thickness than the DSS group. The expression of COX-2, p-STAT3 and p-ERK in colon tissue were significantly suppressed in JRT-M and JRT-H groups compared to that in the DSS group. Moreover, serum TNF-α was significantly suppressed in the JRT-H group compared to that in the DSS group.</p><p><strong>Conclusions: </strong>Jeoryeong-tang has a promising therapeutic potential for treating IBD through its anti-inflammatory properties. Findings of this study suggest that JRT could be a valuable candidate for further clinical investigations in the treatment of IBD.</p>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"15 1","pages":"62-72"},"PeriodicalIF":3.3,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Integrated skin metabolomics and network pharmacology to explore the mechanisms of Goupi Plaster for treating knee osteoarthritis\" [J Tradit, Complementary Altern Med 14 (6) (2024) 675-686].","authors":"Jia Liu, Yingpeng Li, Jiajing Wang, Bixi Guan, Zhaoliang Chen, Ziheng Liu, Yunfeng Xue, Yongji Li, Feng Guan, Yanhong Wang","doi":"10.1016/j.jtcme.2024.11.003","DOIUrl":"https://doi.org/10.1016/j.jtcme.2024.11.003","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.jtcme.2024.04.004.].</p>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"15 1","pages":"106"},"PeriodicalIF":3.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of tiger milk mushroom extract (xLr®) against UVB irradiation in <i>Caenorhabditis elegans via</i> DAF-16 anti-oxidant regulation.","authors":"Panthakarn Rangsinth, Rajasekharan Sharika, Chanin Sillapachaiyaporn, Sunita Nilkhet, Kamonwan Chaikhong, Kanika Verma, Anchalee Prasansuklab, Szu-Ting Ng, Chon-Seng Tan, Shin-Yee Fung, Tewin Tencomnao, Siriporn Chuchawankul","doi":"10.1016/j.jtcme.2024.11.004","DOIUrl":"10.1016/j.jtcme.2024.11.004","url":null,"abstract":"<p><strong>Background and aim: </strong>A critical causative factor of oxidative stress and inflammation leading to several skin complications is ultraviolet-B (UVB) irradiation. <i>Lignosus rhinocerus</i> (LR), or tiger milk mushroom, is native to Southeast Asia. Cold water extract of an LR cultivar, TM02® (xLr®) is a promising anti-oxidant and anti-inflammatory source. However, the effects of xLr® on UVB-induced photoaging have never been elucidated.</p><p><strong>Experimental procedure: </strong>This study investigated the protective effects of xLr® and its high, medium, and low molecular weight (HLR, MLR, and LLR, respectively) fractions against UVB irradiation using <i>in vivo Caenorhabditis elegans</i> (<i>C. elegans</i>) model.</p><p><strong>Results and conclusion: </strong>The investigation revealed a significant lifespan extension of xLr® and its fractions in UVB-irradiated <i>C. elegans</i>, which could be mediated by the regulation of genes associated with anti-oxidant (<i>daf-16</i> and <i>sod-3</i>) and apoptosis (<i>cep-1</i>, <i>hus-1</i>, <i>ced-13</i>, and <i>egl-1</i>) pathways. xLr® significantly reduced the ROS production in <i>C. elegans</i> and increased the DAF-16 nuclear translocation compared to untreated worms. Additionally, the SOD-3 expression was increased in the xLr®-treated worms. Hence, it suggests that the different components in xLr® work synergistically to protect against UVB irradiation. Our findings may be beneficial for the application of xLr® as a treatment against UVB-induced cellular damage and photoaging.</p>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"15 1","pages":"73-83"},"PeriodicalIF":3.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Chinese herbal medicine may reduce major adverse cardiovascular events in patients with dialysis hypotension: A Taiwan nationwide cohort study\" [J Tradit Complementary Med 14, Issue 5 (September 2024), 550-557].","authors":"Ming-Yen Tsai, Po-Yu Huang, Wen-Chin Lee, Ben-Chung Cheng, Fuu-Jen Tsai, Chun-Ting Liu","doi":"10.1016/j.jtcme.2024.09.001","DOIUrl":"https://doi.org/10.1016/j.jtcme.2024.09.001","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.jtcme.2024.03.009.].</p>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"15 1","pages":"105"},"PeriodicalIF":3.3,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From \"traditional\" to modern medicine: A medical and historical analysis of <i>Tagetes erecta</i> L. (Cempasúchil).","authors":"Daniel López Estrada, Wen-Te Chang, Michael Heinrich","doi":"10.1016/j.jtcme.2024.08.001","DOIUrl":"10.1016/j.jtcme.2024.08.001","url":null,"abstract":"<p><p>The medicinal value of herbal products is often rooted in their \"traditional\" use, recontextualized by modern biomedical research granting them certain medical uses. <i>Tagetes erecta</i> L. (Asteraceae), native to Mexico, exemplifies such historical developments of a species that played a key role in developing a major pharmacologically active compound - lutein. T. <i>erecta</i> (Cempasúchil in Nahuatl) has held ritual and medicinal importance in Mesoamerica and was associated with the rain god Tláloc. The species' historical use spans ancient texts with varied medicinal applications, including treating cold-related ailments and promoting menstruation and urination. However, the Spanish conquest redefined it culturally, medicinally, and religiously, mainly as an ornamental flower. The discovery of lutein in <i>T</i>. <i>erecta</i> marked a significant shift, emphasizing its role in macular health and preventing aging-related macular degeneration. Clinically, lutein trials reveal cognitive, visual, cardiovascular, and systemic health enhancements, substantiating its potential therapeutic benefits. Pharmacologically, it demonstrates significant anti-inflammatory, antiparasitic, and anticancer properties. Today, <i>T</i>. <i>erecta</i> is recognized globally for its rich carotenoid content. This multifunctional metabolite is also used in poultry feed and health supplements. In contemporary culture, cempasúchil, also known as the \"flower of the dead,\" has been adapted for ornamental, medicinal, ceremonial, and industrial uses. However, its traditional medicinal uses in pre-Conquest Mexico remain largely unexplored, with its current applications influenced by global research. T. erec<i>ta</i>'s evolution beyond traditional medical and ritual uses in Mesoamerica demonstrates the dynamic development of a medicinal plant's role in medicine, as well as a range of other spheres of daily life.</p>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"15 1","pages":"6-14"},"PeriodicalIF":3.3,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The chemical composition of Diwu YangGan capsule and its potential inhibitory roles on hepatocellular carcinoma by microarray-based transcriptomics","authors":"Qingxin Shi ,&nbsp;Jiangcheng He ,&nbsp;Guangya Chen ,&nbsp;Jinlin Xu ,&nbsp;Zhaoxiang Zeng ,&nbsp;Xueyan Zhao ,&nbsp;Binbin Zhao ,&nbsp;Xiang Gao ,&nbsp;Zhihua Ye ,&nbsp;Mingzhong Xiao ,&nbsp;Hanmin Li","doi":"10.1016/j.jtcme.2023.12.002","DOIUrl":"10.1016/j.jtcme.2023.12.002","url":null,"abstract":"<div><p>The Traditional Chinese Medicine compound preparation known as Diwu Yanggan capsule (DWYG) can effectively hinder the onset and progression of hepatocellular carcinoma (HCC), which is recognized worldwide as a significant contributor to fatalities associated with cancer. Nevertheless, the precise mechanisms implicated have remained ambiguous. In present study, the model of HCC was set up by the 2-acetylaminofluorene (2-AAF)/partial hepatectomy (PH) in rats. To confirm the differentially expressed genes (DEGs) identified in the microarray analysis, real-time quantitative reverse transcription PCR (qRT-PCR) was conducted. In the meantime, the liquid chromatography-quadrupole time of flight mass spectrometry (LC-QTOF-MS/MS) was employed to characterize the component profile of DWYG. Consequently, the DWYG treatment exhibited the ability to reverse 51 variation genes induced by 2-AAF/PH. Additionally, there was an overlap of 54 variation genes between the normal and model groups. Upon conducting RT-qPCR analysis, it was observed that the expression levels of all genes were increased by 2-AAF/PH and subsequently reversed after DWYG treatment. Notably, the fold change of expression levels for all genes was below 0.5, with 3 genes falling below 0.25. Moreover, an investigation was conducted to determine the signaling pathway that was activated/inhibited in the HCC group and subsequently reversed in the DWYG group. Moreover, the component profile of DWYG encompassed a comprehensive compilation of 206 compounds that were identified or characterized. The findings of this study elucidated the potential alleviative mechanisms of DWYG in the context of HCC, thereby holding significant implications for its future clinical utilization and widespread adoption.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 4","pages":"Pages 381-390"},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411023001360/pdfft?md5=bfa76b9673e97a298fbe5a8c4cb54ab9&pid=1-s2.0-S2225411023001360-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139193418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture improves articular microcirculation and attenuates cartilage hypoxia in a male rabbit model of knee osteoarthritis","authors":"Ma Weiwei ,&nbsp;Du Mei ,&nbsp;Lu Juan ,&nbsp;Xing Longfei ,&nbsp;Chen Xilin ,&nbsp;Hu Tingyao ,&nbsp;Zhu Wenting ,&nbsp;Guo Changqing","doi":"10.1016/j.jtcme.2024.01.002","DOIUrl":"10.1016/j.jtcme.2024.01.002","url":null,"abstract":"<div><h3>Background and aim</h3><p>Hypoxia of the cartilage has been considered as a potential pathogenic factor in knee osteoarthritis (KOA). Studies have shown that impaired blood perfusion of joint leads to cartilage hypoxia. Electroacupuncture (EA) has proven effects on pain relief and improving microcirculation. This study aimed to explore the effect of EA on articular microcirculation and cartilage anoxic and the underlying mechanisms.</p></div><div><h3>Procedures</h3><p>Videman's method was used for 6 weeks to establish the KOA model. EA intervention was performed in four points around the knee for 3 weeks after KOA modeling. The Lequesne MG score was used to assess ethology. We recorded the oxygen tension of synovial fluid and the synovial microcirculation in vivo. HE-staining was used to assess cartilage morphology, and immunohistochemistry (IHC), Western blotting, and RT-PCR were used to assess expression of the major glycolytic enzymes glucosetransporter1 (GLUT1), pyruvate kinase M2(PKM2), and lactate dehydrogenase A (LDHA). Enzyme-linked immunosorbent assay (Elisa) was used to detect lactate content.</p></div><div><h3>Results and conclusion</h3><p>There was a significant decrease in Lequesne MG score and improvement in Mankin score after EA intervention (P &lt; 0.01), a significant increase in synovial microcirculation (P &lt; 0.05) and synovial fluid oxygen tension (P &lt; 0.01), and there was significant decrease in the expression of GLUT1, PKM2 and LDHA (P &lt; 0.01) and lactate (P &lt; 0.05). This study suggested that EA ameliorate cartilage hypoxia and regulate glycolytic metabolism in chondrocytes in KOA model rabbits by improving articular microcirculation and oxygen tension.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 4","pages":"Pages 414-423"},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411024000026/pdfft?md5=fc573f1adf9c6cdfa3fad8fda1b0460f&pid=1-s2.0-S2225411024000026-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139394091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sophorae tonkinensis radix polysaccharide attenuates acetaminophen-induced liver injury by regulating the miR-140-5p-related antioxidant mechanism","authors":"Liangliang Cai ,&nbsp;Lixing Xu ,&nbsp;Kai Shen ,&nbsp;Qin Wang ,&nbsp;Ronghua Ni ,&nbsp;Xin Xu ,&nbsp;Xiaofei Ma","doi":"10.1016/j.jtcme.2024.01.006","DOIUrl":"10.1016/j.jtcme.2024.01.006","url":null,"abstract":"<div><p>STRP1, a polysaccharide active ingredient isolated from the traditional Chinese medicine <em>Sophorae tonkinensis radix</em>, has demonstrated a protective effect against acetaminophen (APAP)-induced liver injury (AILI). The underlying molecular mechanism was investigated in this study. Here, an acute liver damage mouse model was generated by APAP (400 mg/kg) and used to identify the protective effect of STRP1 (200 mg/kg) on mouse livers. In vitro cell experiments were used to further verify the related signaling pathways. Initially, in our study, STRP1 treatment reduced APAP-induced liver injury by decreasing aminotransferase activity and cell apoptosis and increasing cell proliferation. Furthermore, STRP1 treatment significantly increased <em>Nrf2</em> expression and alleviated oxidative stress caused by reactive oxygen species in AILI. Based on bioinformatics and experimental studies, miR-140-5p was identified and found to be reduced by STRP1, increasing <em>Nrf2</em> expression. Additionally, <em>Nrf2</em> played an important role in the protective impact of STRP1-suppressed miR-140-5p expression. Generally, these results showed that STRP1-mediated suppression of miR-140-5p expression mitigates AILI by activating the <em>Nrf2</em>-mediated Nrf2-Keap1 pathway. This study revealed that STRP1 might be a potential treatment agent for AILI.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 4","pages":"Pages 467-476"},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411024000063/pdfft?md5=6344fc8428deb46231aa1beaad07448e&pid=1-s2.0-S2225411024000063-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139540029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atractylodes macrocephala Koidz. and Cuscuta chinensis Lam. extract relieves insulin resistance via PI3K/Akt signalling in diabetic Drosophila","authors":"Yinghong Li ,&nbsp;Ye Xu ,&nbsp;Biwei Zhang ,&nbsp;Zhigang Wang ,&nbsp;Leilei Ma ,&nbsp;Longyu Sun ,&nbsp;Xiuping Wang ,&nbsp;Yimin Lin ,&nbsp;Ji-an Li ,&nbsp;Chenxi Wu","doi":"10.1016/j.jtcme.2024.01.010","DOIUrl":"10.1016/j.jtcme.2024.01.010","url":null,"abstract":"<div><h3>Background and aim</h3><p>Type-2 diabetes mellitus (T2DM) is mainly characterized by insulin resistance (IR) induced by hyperglycaemia and insufficient insulin secretion. We employed a diabetic fly model to examine the effect and molecular mechanism of <em>Atractylodes macrocephala</em> Koidz. and <em>Cuscuta chinensis</em> Lam. (AMK–CCL) extract as traditional Chinese medicine in treating IR and T2DM.</p></div><div><h3>Experimental procedure</h3><p>The contents of the active ingredients (rhamnose, xylose, mannose, and hyperoside) in AMK–CCL extract were determined by high-performance liquid chromatography. Wild-type (<em>Cg-</em>GAL4/+) or diabetic (<em>Cg</em> &gt; InR^K1409A) <em>Drosophila</em> flies were divided into the control group or metformin group and AMK–CCL (0.0125, 0.025, 0.05, 0.1 g/ml) groups. Food intake, haemolymph glucose and trehalose, protein, weight, triglycerides (TAG), and glycogen were measured to assess glycolipid metabolism. Phosphatidylinositol-3-kinase (PI3K)/Akt signalling was detected using fluorescent reporters [tGPH, <em>Drosophila</em> forkhead box O (dFoxO)–green fluorescent protein (GFP), <em>Glut1</em>–GFP, 2-NBDG] <em>in vivo</em>. <em>Glut1/</em>3 mRNA levels and Akt phosphorylation levels were detected by quantitative polymerase chain reaction and western blotting, respectively, <em>in vitro</em>.</p></div><div><h3>Results</h3><p>AMK–CCL extract contained 0.038 % rhamnose, 0.017 % xylose, 0.69 % mannose, and 0.039 % hyperoside. AMK–CCL at 0.0125 g/mL significantly suppressed the increase in circulating glucose, and the decrease in body weight, TAG, and glycogen contents of diabetic flies. AMK–CCL improved PI3K activity, Akt phosphorylation, Glut1/3 expression, and glucose uptake in diabetic flies, and also rescued diabetes-induced dFoxO nuclear localisation.</p></div><div><h3>Conclusions</h3><p>These findings indicate that AMK–CCL extract ameliorates IR-induced diabetes via the PI3K/Akt signalling pathway, providing an experimental basis for clinical treatment.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 4","pages":"Pages 424-434"},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411024000105/pdfft?md5=6b23edcc8ec860e3dba0c8b648b13f51&pid=1-s2.0-S2225411024000105-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140527368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective effects of Tradescantia spathacea tea bioactives in Parkinson’s disease: In vivo proof-of-concept","authors":"Lorenna E.S. Lopes ,&nbsp;Sheilla da Silva Barroso ,&nbsp;Joanny K.M. Caldas ,&nbsp;Paulo R. Vasconcelos ,&nbsp;Kirley M. Canuto ,&nbsp;Claudio Dariva ,&nbsp;Klebson S. Santos ,&nbsp;Patricia Severino ,&nbsp;Juliana C. Cardoso ,&nbsp;Eliana B. Souto ,&nbsp;Margarete Z. Gomes","doi":"10.1016/j.jtcme.2024.01.003","DOIUrl":"10.1016/j.jtcme.2024.01.003","url":null,"abstract":"<div><h3>Background and aim</h3><p><em>Tradescantia spathacea</em> (<em>T. spathacea</em>) is a traditional medicinal plant from Central America and its tea, obtained by infusion, has been recognized as a functional food. The aim of this work was to investigate the effects of dry tea containing biocompounds from <em>T. spathacea</em> tea on motor and emotional behavior, as well as tyrosine hydroxylase (TH) and glial fibrillary acidic protein (GFAP) expression in 6-hydroxydopamine (6-OHDA)-lesioned rats.</p></div><div><h3>Experimental procedure</h3><p>Bioactives were identified by Ultra Performance Liquid Chromatography (UPLC) and an <em>in vivo</em> study in male Wistar rats was run as proof of concept of neuroprotective effects of DTTS.</p></div><div><h3>Results and conclusion</h3><p>We found 15 biocompounds that had not been previously reported in <em>T. spathacea</em>: the UPLC-QTOF-MS/MS allowed identification five phenolic acids, one coumarin, two flavonoids, one iridoid, one phenylpropanoid glycoside, and six fatty acid derivatives. The dry tea of <em>T. spathacea</em> (DTTS) presented significant antioxidant activity and high contents of phenolic compounds and flavonoids. Doses of 10, 30, and 100 mg/kg of DTTS were protective against dopaminergic neurodegeneration and exhibited modulatory action on the astrocyte-mediated neuroinflammatory response. Behavioral tests showed that 30 mg/kg of DTTS counteracted motor impairment, while 100 mg/kg produced an anxiolytic effect. The DTTS could be, therefore, a promising strategy for the management of Parkinson's disease.</p></div>","PeriodicalId":17449,"journal":{"name":"Journal of Traditional and Complementary Medicine","volume":"14 4","pages":"Pages 435-445"},"PeriodicalIF":3.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2225411024000038/pdfft?md5=60ab07b9c5f33562dd6de3c77145b80a&pid=1-s2.0-S2225411024000038-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139458247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}