Journal of Pain Research最新文献

{"title":"\"Zhibian (BL54) to Shuidao (ST28)\" Acupuncture Manipulation Combined with Analgesics in Postoperative Pain Management for Patients with Mixed Hemorrhoids: A Randomized Controlled Trial Protocol.","authors":"Te Wang, Jun Qiang Gao, Min Chang, Ming Chen Ma, Yu Tong Wang, Tu Ning Guo, Yan Lin Zhang, Zhen Gao, Hai Jun Wang, Yu Xia Cao","doi":"10.2147/JPR.S519232","DOIUrl":"https://doi.org/10.2147/JPR.S519232","url":null,"abstract":"<p><strong>Purpose: </strong>Mixed hemorrhoids patients often face severe postoperative pain, typically treated with Non-steroidal anti-inflammatory drugs (NSAIDs) or opioids, which may lead to gastrointestinal and Central Nervous System (CNS) side effects. The \"Zhibian (BL54) to Shuidao (ST28)\" manipulation acupuncture combined with analgesics shows promise as a safe and effective alternative. Thorough randomized controlled trials (RCTs) are crucial for determining the effectiveness and safety when used in conjunction with pain relievers.</p><p><strong>Patients and methods: </strong>This double-blind randomized controlled trial aims to assess the effectiveness and safety of the acupuncture method connecting the \"Zhibian (BL54)\" and \"Shuidao (ST28)\" points combined with analgesics in alleviating pain following surgery for mixed hemorrhoids. A total of 104 patients who meet diagnostic criteria and undergo Milligan-Morgan open hemorrhoidectomy (MMH) will be randomized into control (n = 52) or acupuncture (n = 52) groups. The control group will receive diclofenac sodium, while the acupuncture group will additionally undergo the \"Zhibian (BL54) to Shuidao (ST28)\" manipulation acupuncture. The intervention will span a duration of five days, with data collection occurring both prior to and following the intervention. Primary outcomes include Visual analogue scale (VAS) scores for pain, with secondary outcomes assessing analgesic efficiency, increased pain medication use, and pain interference in daily activities. Statistical analysis will be conducted utilizing SPSS software, version 26.0.</p><p><strong>Discussion: </strong>This forward-looking, randomized study aims to assess the effectiveness of combining acupuncture with medication in alleviating postoperative pain for individuals suffering from mixed hemorrhoids, wih the goal of establishing a safe and potent therapeutic strategy and broadening the clinical applications of this intervention.</p><p><strong>Conclusion: </strong>This randomized study evaluates the effectiveness of combining acupuncture with medication to relieve postoperative pain in patients with mixed hemorrhoids, aiming to establish a safe and effective treatment strategy and expand its clinical use.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2163-2174"},"PeriodicalIF":2.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Electroacupuncture Parameters for Irritable Bowel Syndrome: A Data Mining Approach.","authors":"Yang Tang, Xiao Tang, Qiao Wen","doi":"10.2147/JPR.S483750","DOIUrl":"https://doi.org/10.2147/JPR.S483750","url":null,"abstract":"<p><strong>Purpose: </strong>Irritable bowel syndrome (IBS), a prevalent functional bowel disorder, has increasingly seen acupuncture incorporated into its clinical management. Despite this, a comprehensive summary of electroacupuncture (EA) stimulation parameters and acupoint prescriptions tailored for IBS remains absent. This study endeavors to identify effective EA parameters for IBS through data mining methodologies.</p><p><strong>Methods: </strong>To retrieve randomized controlled trials (RCTs) on EA for IBS published between 2013 and 2024, a comprehensive search was conducted across nine databases. EA parameters from eligible studies were extracted and evaluated for quality using the Cochrane's risk of bias tool (RoB 2). Descriptive statistics were computed using MS-Excel^®. Association rule analysis was undertaken in SPSS Modeler, whereas complex network analysis and co-occurrence network analyses were performed using Gephi and Origin, respectively.</p><p><strong>Results: </strong>A total of 30 RCTs involving 2906 participants were included. All included studies exhibit a low to high risk of bias. Key methodologic weaknesses are mainly attributed to insufficient randomization and lack of blinding. The frequently reported EA stimulation parameters were a frequency of 2 hz, using either dilatational or continuous waves, with a treatment duration of 30 minutes, a 4-week course, and once daily treatment. Across 32 acupoint prescriptions, 27 acupoints were identified, with the stomach and bladder meridians being the most frequently targeted. Acupoints ST25, ST37, and ST36 were most frequently used. The most supported combination of acupoints could be (ST25→ST37); <i>k</i>-core hierarchical analysis of complex networks revealed the core acupoints for IBS treatment, including ST25, ST37, ST36, SP6, LR3, BL25, LI11 and RN4.</p><p><strong>Conclusion: </strong>A regimen combining dilatational/continuous waves, 2 hz, a 30-minute stimulus, a 4-week course, and the acupoint combination (ST25→ST37) may serve as a primary EA protocol for IBS. However, methodological constraints may undermine the robustness of these findings. Therefore, the clinical application of these therapeutic modalities requires further validation.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2175-2189"},"PeriodicalIF":2.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12034281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opioid-Free versus Opioid-Sparing Anesthesia for Postoperative Pain and Early Recovery After Laparoscopic Cholecystectomy: A Randomized Controlled Trial.","authors":"Miaomiao Xiong, Yao Liu, Yingsi Liang, Hailang Wang, Lili Zhang, Zhongjun Zhang, Ming Fang","doi":"10.2147/JPR.S506147","DOIUrl":"https://doi.org/10.2147/JPR.S506147","url":null,"abstract":"<p><strong>Purpose: </strong>Enhanced recovery after surgery emphasizes effective analgesia while minimal opioid use. Opioid-free anesthesia (OFA) and opioid-sparing anesthesia (OSA) have been shown to enhance recovery by reducing opioid-induced side effects. This study compared the efficacy of OFA and OSA in managing postoperative pain and recovery after laparoscopic cholecystectomy (LC).</p><p><strong>Patients and methods: </strong>A single-center, randomized controlled trial was conducted with 86 adults undergoing LC. Patients received either OSA (sufentanil/remifentanil) or OFA (no opioids). Both groups received propofol, esketamine, dexmedetomidine, and erector spinae plane block. The primary outcome was pain area under the curve (AUCVAS) within 36 hours postsurgery. Secondary outcomes included hemodynamics, recovery times and bowel function.</p><p><strong>Results: </strong>Eighty-one patients (41 and 40 in the OFA and OSA groups, respectively) completed the study. The AUCVAS scores were similar between the OFA (7.3 ± 1.4) and OSA (6.9 ± 1.3) groups (P = 0.201), the difference in AUCVAS between the two groups was 0.384 (95% CI: -0.296, 1.064), which was significantly below the preset noninferiority threshold of 1.0, demonstrating the noninferiority of OFA. While early pain scores within the first 12 hours postanesthesia care unit (PACU) discharge were slightly higher in the OFA group, but overall pain control was sufficient in both groups. The VAS scores from PACU discharge to 36 hours postoperatively, intraoperative hemodynamic variables, and the need for rescue analgesia were comparable. OFA patients experienced a faster bowel recovery (13.8 ± 2.4 vs 15.5 ± 2.3 hours, P = 0.002). Recovery times, postoperative QoR-40 scores, and patient satisfaction were similar between the groups.</p><p><strong>Conclusion: </strong>OFA is noninferior to OSA in pain management and hemodynamic stability, with faster bowel recovery after LC.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2137-2146"},"PeriodicalIF":2.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Device Evaluation, Treatment, and Explantation Recommendations (DETER): Review and Best Practices for Managing Neuromodulation Device Infections.","authors":"Scott G Pritzlaff, Johnathan Heck Goree, Ryan Keith Dare, Ryan S D'Souza, David W Lee, Andrew Adams Dudas, Hemant Kalia, Vwaire Orhurhu, Naileshni Singh, Jonathan Michael Hagedorn, Arman Mousavi, Whitney James, Michael Spencer Leong, Kathleen W Meacham, Amitabh Gulati, Samir J Sheth, Israel Pena, Jarna R Shah, Melissa Zhu Murphy, Sara E Nashi, Morad Nasseri, Andrew M Khoury, Michael J Dorsi, Steven Michael Falowski, Erika A Petersen, Nestor D Tomycz, Sayed Wahezi, Krishnan V Chakravarthy, Jason E Pope, Michael E Schatman, Kasra Amirdelfan, Dawood Sayed, Timothy Ray Deer","doi":"10.2147/JPR.S509623","DOIUrl":"https://doi.org/10.2147/JPR.S509623","url":null,"abstract":"<p><p>Infections related to neuromodulation devices such as spinal cord stimulators (SCS) and intrathecal pumps (ITPs) present complex challenges due to potential complications such as localized infections, deep infections, sepsis, and neurological injury. Prompt diagnosis requires patients and providers to be educated on wound management and sepsis symptoms for immediate medical attention. Antibiotic therapy and duration vary based on infection severity, with deep infections often requiring device removal despite recent improvements in salvage rates with aggressive initial intervention. Deep infections necessitate timely diagnosis through imaging modalities such as magnetic resonance imaging (MRI) or computed tomography (CT), followed by device removal and culture-guided antibiotic therapy, often in collaboration with infectious disease specialists and spine surgeons. ITP infections pose similar challenges along with the risk of meningitis and may require careful management of medication withdrawal symptoms during emergent pump removal. Lab monitoring may aid treatment assessment, although negative cultures can occur due to post-antibiotic exposure. Postoperative recommendations stress standardized guidelines, patient education, and vigilant surveillance, with close follow-up crucial for early infection detection and intervention. Managing device-related infections demands a multi-specialty approach to minimize complications and optimize outcomes. This paper outlines best practices for diagnosing, managing, and treating neuromodulation device infections, focusing on guiding clinical decision-making from the onset of infection through treatment and potential reimplantation.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2147-2161"},"PeriodicalIF":2.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Articaine Needle - Free Anesthesia Vs Conventional Anesthesia in Root Canal Treatment of Irreversible Pulpitis in Permanent Teeth: A Prospective Study on Anesthetic Efficacy and Effects on Pain.","authors":"Suhui Qian, Ziying Meng, Haiyan Zhang, Kaicheng Li, Fei Zhang, Sen Zhang, Jianfei Liu, Zhou Zhou","doi":"10.2147/JPR.S514944","DOIUrl":"https://doi.org/10.2147/JPR.S514944","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to compare the anesthetic efficacy of articaine needle-free anesthesia with conventional lidocaine nerve block anesthesia for root canal treatment in permanent teeth with irreversible pulpitis.</p><p><strong>Methods: </strong>In this prospective clinical trial, 94 patients were randomly allocated to receive either articaine needle-free anesthesia (n=47) or lidocaine nerve block anesthesia (n=47). Anesthetic effectiveness was evaluated through onset time, success rate, and visual analog scale (VAS) pain scores during crown opening and pulp removal procedures. Secondary outcomes included hemodynamic stability (heart rate, systolic and diastolic blood pressure) and incidence of adverse reactions.</p><p><strong>Results: </strong>The articaine group exhibited significantly faster anesthesia onset (7.62±1.28 minutes vs 9.35±2.04 minutes, p<0.05) and higher success rate (93.62% vs 80.85%, p<0.05). Patients receiving articaine reported significantly lower pain scores during crown opening (4.31±1.13 vs 5.48±1.06) and pulp removal (3.18±1.07 vs 4.26±1.12) (both p<0.05). Both groups maintained comparable hemodynamic stability throughout the procedure (p>0.05), with no significant difference in adverse reaction rates (11.49% vs 10.64%, p>0.05).</p><p><strong>Conclusion: </strong>Articaine needle-free anesthesia demonstrates superior clinical performance compared to conventional lidocaine nerve block, offering faster onset, improved success rate, and enhanced pain control during root canal treatment of irreversible pulpitis, while maintaining equivalent safety parameters. These findings support its adoption as an effective alternative for dental anesthesia in endodontic procedures.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2115-2125"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12024466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on the Developmental Trajectory of Movement-Evoked Pain and Its Potential Predictors in Patients After Knee Arthroplasty.","authors":"Shanshan Ai, Sumin Zhao, Lihui Yan, Hangying Hu, Pengli Niu, Yueli Zhu, Meifang Zheng","doi":"10.2147/JPR.S510554","DOIUrl":"https://doi.org/10.2147/JPR.S510554","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the developmental trajectory of movement-evoked pain after knee arthroplasty and analyze the predictors of different developmental trajectory categories.</p><p><strong>Patients and methods: </strong>In this study, a total of 178 patients undergoing knee arthroplasty were recruited from the Department of Joint Surgery at a tertiary care hospital in China. Participants completed the General Data Questionnaire, the Social Support Revaluated Scale, and the Pain Catastrophizing Scale on the day before surgery (T1). Movement-evoked pain was assessed using the Pain Numerical Rating Scale at 24 hours (T2), 48 hours (T3), and 72 hours (T4) after knee arthroplasty. The growth mixture model was utilized to identify the developmental trajectories of movement-evoked pain after knee arthroplasty.</p><p><strong>Results: </strong>Three developmental trajectories of movement-evoked pain after knee arthroplasty were identified: the moderate pain-rise then decline group (47.75%), the moderate pain-continuous decline group (11.80%), and the severe pain-continuous stable group (40.45%). Multivariate logistic regression analysis indicated that social support, pain catastrophization, education, disease duration, and operation time were significant predictors of the types of movement-evoked pain in knee arthroplasty patients (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>This study identifies three potential categories of movement-evoked pain developmental trajectories after knee arthroplasty, with the moderate pain-rising then falling group being the most common. Significant predictors include social support, pain catastrophization, education, disease duration, and operation time.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2127-2136"},"PeriodicalIF":2.5,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12024463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Clinical Symptoms of Unilateral S1 Nerve Injury Caused by Disc Herniation the via High Resolution MRI and DTI.","authors":"ChaoYang Zhang, Wei Hao, Xiaobo Guo, Yuna Zhang, Hao Fu, Jiashan Zhang","doi":"10.2147/JPR.S507867","DOIUrl":"https://doi.org/10.2147/JPR.S507867","url":null,"abstract":"<p><strong>Background: </strong>The status of the herniated disc or nucleus pulposus and the extent of injury and clinical symptoms of the compressed S1 nerve fiber bundle were evaluated by high-resolution Magnetic resonance imaging (MRI) and Diffusion tensor imaging (DTI) techniques.</p><p><strong>Methods: </strong>Forty-two clinically proven patients with unilateral S1 nerve root compression were selected as the case group (n=42), and 20 healthy volunteers were selected as the control group (n=20). The general data, MRI features and DTI parameters were compared between groups. The effective indicators of S1 neurologic fiber bundle damage were screened by univariate logistic regression analysis and receiver operating characteristic (ROC) curve, and multi-factor logistic regression models were constructed to analyze the diagnostic efficiency of each model.</p><p><strong>Results: </strong>There were no significant differences in age, gender, height, weight, fractional anisotropy (FA) value and apparent diffusion coefficient (ADC) value on both sides of S1 nerve root between groups (P >0.05). The FA value and ADC value of the nerve root on the affected side of the patient were significantly different from those on the healthy side and those on the corresponding side of the control group (all P <0.05), and all of them were effective indicators of the damage of S1 nerve. The sensitivity, specificity and area under the curve of the damaged nerve fiber bundle were detected by multi-factor logistic regression models constructed with FA+rFA and FA+rFA+rADC of the affected nerve root, respectively 95.20%, 72.00%, 0.939, and 97.60%, 80.00%, 0.944.</p><p><strong>Conclusion: </strong>High-resolution MRI and DTI can quantitatively evaluate the degree of nerve fiber bundle injury and clinical symptoms caused by lumbar disc herniation.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2105-2114"},"PeriodicalIF":2.5,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12013630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Multifactorial Predictors of Pain in Chronic Musculoskeletal Pain: A Regression-Based Study.","authors":"Angel González-de-la-Flor, María Bravo-Aguilar, Jaime Almazán-Polo, Guillermo García-Pérez-de-Sevilla, Pedro Martínez-Lozano, Carlos Romero-Morales","doi":"10.2147/JPR.S500636","DOIUrl":"https://doi.org/10.2147/JPR.S500636","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess differences in pain neurophysiology knowledge between individuals with chronic musculoskeletal pain (CMP) and those without CMP, and to explore associations between pain knowledge, pain intensity, and demographic and lifestyle factors.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with 171 participants, including 120 with CMP and 51 without CMP. Sociodemographic, pain-related, and lifestyle data were collected. Pain knowledge was assessed using the Revised Neurophysiology of Pain Questionnaire (R-NPQ). Statistical analyses included t-tests, chi-squared tests, Pearson's correlation, and stepwise regression models to identify predictors of pain intensity and CMP presence.</p><p><strong>Results: </strong>Significant differences were found between participants with and without CMP in BMI (p<0.001), physical activity (p=0.023), education level (p=0.002), and alcohol consumption (p=0.017). Participants with CMP scored lower on the R-NPQ (mean 4.40 ± 2.1) than those without CMP (mean 6.31 ± 2.03; p<0.001). Pain intensity was negatively associated with R-NPQ scores (r=-0.315; p<0.001), physical activity (r=-0.199; p=0.030), and education level (rho=0.236; p=0.010). Stepwise regression analysis revealed that R-NPQ scores (20.7%), BMI (6.7%), education level (3.9%), and physical activity (2.6%) collectively explained 33.9% of the variance in pain intensity (adjusted R²=0.339). Binary logistic regression identified BMI, R-NPQ scores, and education level as significant predictors of CMP presence, with higher BMI and lower R-NPQ scores increasing the odds of CMP, while higher education levels and physical activity were predictive factors.</p><p><strong>Conclusion: </strong>Individuals with CMP exhibited lower knowledge of pain neurophysiology, higher BMI, reduced physical activity levels, and lower educational attainment, all of which were associated with increased pain intensity and a greater likelihood of CMP presence.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2081-2091"},"PeriodicalIF":2.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous Endoscopic Backhand Holding (EBH) Technique for Extraforaminal Lumbar Disc Herniations: A Modified Operative Technique.","authors":"Meng Kong, Changtong Gao, Meng Hao, Xuexiao Ma, Jindong Zhao, Jian Luan, Yong Lin, Canghai Jin, Qiang Li","doi":"10.2147/JPR.S498090","DOIUrl":"https://doi.org/10.2147/JPR.S498090","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous endoscopic lumbar discectomy (PELD) is a minimally invasive surgical (MIS) procedure rapidly improved in the surgical treatment of lumbar disc herniation (LDH). For the treatment of extraforaminal lumbar disc herniations (ELDH), microendoscopic discectomy (MED) or traditional Transforaminal Lumbar Interbody Fusion (MIS-TLIF) are commonly used, but limitations exist due to bony resection. Many classic surgical approaches for PELD have inherent disadvantage when removing migrated ELDH.</p><p><strong>Objective: </strong>We aimed to present the results of a series of PELD cases that were operated using a modified endoscopic backhand holding (EBH) approach for the treatment of ELDH.</p><p><strong>Methods: </strong>Seventy-two patients diagnosed with ELDH who underwent PELD via the EBH approach from January 2018 to December 2022 were retrospectively assessed. Pre- and postoperative clinical data, radiographic findings, and surgical techniques were investigated. Neurological recovery examinations were performed preoperatively and at 3 days, 1 month, 3 months, 6 months, 1 year postoperatively.</p><p><strong>Results: </strong>No major intraoperative complications were noted. Significant improvement in back and leg pain was observed in visual analogue scale (VAS) score, and the mean ODI was decreased from preoperative 78% (range = 60-98%) to postoperative 30% (20-40%) (<i>P</i> < 0.001) at 1-month follow-up and obtained further improvement at 1 year (mean ODI = 11%; range = 2-20%). All patients showed progressive improvement in their initial neurological deficits, with complete recovery of motor weakness. According to the Macnab criteria, overall excellent and good outcomes were obtained in 67 patients (95.7%) - 57 excellent (81.4%), and 10 (14.3%) good - with fair outcomes in three patients (4.3%) at the time of last follow-up.</p><p><strong>Conclusion: </strong>Percutaneous endoscopic backhand holding is a minimally invasive, safe, valuable, and efficacious surgical procedure for treating ELDH. It is important that surgeons perform PELD using the technique they know best to ensure successful implementation of the surgery.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2069-2080"},"PeriodicalIF":2.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Migraine Headache and Its Related Disability Factors Among University Students in Jordan: A Cross-Sectional Study.","authors":"Miral A Almomani, Basima A Almomani, Nour A Al-Sawalha, Ahmad A Alqudah","doi":"10.2147/JPR.S504602","DOIUrl":"https://doi.org/10.2147/JPR.S504602","url":null,"abstract":"<p><strong>Introduction: </strong>Headache is a common complaint in medical practice that affects daily activity and quality of life. University students, especially, face psychological and academic stressors that may trigger migraine, leading to functional impairment. This can hinder concentration, studying, and academic performance, resulting in disability, reduced productivity, and absenteeism. Understanding the factors contributing to headache-related disability in Jordanian students is essential for improving mental health and guiding policies to promote academic success and overall well-being.</p><p><strong>Aim: </strong>The purpose of this study was to investigate the prevalence, features, and determinants of migraine headache-related disability among university students in Jordan.</p><p><strong>Methods: </strong>A cross-sectional survey was conducted among university students in Jordan. An online questionnaire was distributed using social media. A convenient sample of students from different universities across geographical areas in Jordan was invited to participate in the study.</p><p><strong>Results: </strong>Out of 1276 recruited participants, 64.97% of them have a history of headache in the previous 3 months. Of those, 80.22% probably have a diagnosis of migraine headache and 46% of them have an aura. Photophobia was the most common associated symptom (~90%) and sleep disturbance was the most reported factor trigger migraine attacks (83%). Most of the participants (82%) used analgesic medications, mainly OTC drugs (66.8%). Students with severe migraine intensity were more likely to have moderate-severe disability than those with mild/moderate intensity (OR = 1.69, 95 CI% = 1.23-2.34, p value = 0.001). In addition, the presence of an aura was associated with moderate-severe disability (OR = 1.57, 95 CI% = 1.14-2.16, p value = 0.006).</p><p><strong>Conclusion: </strong>This study highlights the high prevalence of migraine headache among university students in Jordan, with photophobia and sleep disturbances identified as common triggers. The findings suggest that students with severe migraine intensity and those experiencing aura are more likely to face moderate-to-severe disability. The widespread use of analgesic medications, particularly over-the-counter drugs, underscores the need for targeted interventions to manage migraine symptoms and enhance the quality of life for affected students.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2093-2104"},"PeriodicalIF":2.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}