Journal of Pain Research最新文献

{"title":"Validation of the Thai Version of the Chronic Pain Acceptance Questionnaire-8 (CPAQ-8T) in Chronic Pain Patients.","authors":"Koravee Pasutharnchat, Rattaphol Seangrung, Prateep Lertmongkonaksorn, Sirima Kamdeang","doi":"10.2147/JPR.S500597","DOIUrl":"10.2147/JPR.S500597","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic pain significantly affects patients' quality of life, leading to the avoidance of activities that exacerbate their pain. Embracing pain acceptance and willingness is crucial to maintain patients' functionality. This study aimed to translate and validate the Chronic Pain Acceptance Questionnaire-8 (CPAQ-8) into the Thai language and to facilitate the assessment of pain acceptance in Thai patients.</p><p><strong>Patients and methods: </strong>The study involved the translation of the English CPAQ-8 into a Thai version, subsequently, referred to as the CPAQ-8T. The psychometric properties of the CPAQ-8T were examined. Study participants were administered a set of questionnaires, including the 100-mm Visual Analog Scale (VAS), CPAQ-8T, and the Barthel Index for Activities of Daily Living (ADL). Test-retest reliability was assessed by readministering the CPAQ-8T two weeks after the initial test. The validity and overall reliability of the CPAQ-8T were thoroughly assessed.</p><p><strong>Results: </strong>A total of 160 patients with chronic pain at pain clinic, Ramathibodi Hospital completed all the questionnaires. The mean CPAQ-8T score was 24.2 (SD = 7.26). The CPAQ-8T score exhibited the expected correlation with the Barthel Index for ADL but showed no significant correlation with the VAS score, indicating moderate convergent validity. The internal consistency and test-retest reliability findings support the validity and reliability of the CPAQ-8T.</p><p><strong>Conclusion: </strong>The translation and validation of the CPAQ-8 into the Thai language offers a reliable and valid instrument for assessing pain acceptance in Thai patients with chronic pain. The results suggested that the CPAQ-8T is a valuable tool for healthcare professionals and researchers working in the field of chronic pain management.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"947-957"},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and Experimental Verification of Potential Immune Cell-Associated Gene Biomarkers in Human Intervertebral Disc Degeneration.","authors":"Wei-Han Shi, Hui-Shuang Zou, Xiang-Yu Wang, Jie Lu, Hua-Qi Yu, Ping-Ping Zhang, Li-Li Huang, Peng-Cheng Chu, Da-Chuan Liang, Ya-Ning Zhang, Bin Li","doi":"10.2147/JPR.S505859","DOIUrl":"10.2147/JPR.S505859","url":null,"abstract":"<p><strong>Objective: </strong>Intervertebral disc degeneration (IDD) is one of the most common diseases in the elderly population. Recently, immune disorders have been considered to play an important role in IDD. This study aimed to conduct a bioinformatic analysis to identify biomarkers associated with IDD immune cells.</p><p><strong>Methods: </strong>We obtained the gene expression profiles of IDD by downloading the Gene Expression Omnibus Series (GSE)150408 and GSE124272 from the Gene Expression Omnibus (GEO) database. IDD and immune cell-related hub genes were identified via multiple bioinformatics analyses, and their diagnostic performance was evaluated using receiver operating characteristic (ROC) analysis. In addition, a long non-coding RNA (lncRNA)-signature gene co-expression network was constructed. Finally, the diagnostic accuracy of the biomarkers was verified using Real-time quantitative PCR (RT-qPCR).</p><p><strong>Results: </strong>ASAP1-IT1, IKZF2, KLHL14, lnc-C10orf131-1, and LOC101927805 were identified as signature genes of IDD. Further, ROC analysis revealed that the five signature gene models had a strong ability to discriminate between the IDD and healthy control samples. We also found that the five signature genes were significantly associated with immune-inflammatory feedback, cell cycle, and skeletal system. Furthermore, an lncRNA signature gene network was constructed to reveal the regulatory mechanisms of the biomarkers. Finally, RT-qPCR results verified that IKZF2 and KLHL14 were significantly downregulated in patients with IDD, and ASAP1-IT1 was significantly upregulated.</p><p><strong>Conclusion: </strong>This study identified ASAP1-IT1, IKZF2, and KLHL14 as the key signature genes of IDD. These key hub genes may serve as potential therapeutic targets for IDD.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"993-1007"},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analgesic Quality Improvement in Paravertebral Blocks for Pediatric Nuss Procedure: An Exploratory Report on the Effects of Perineural Combined Glucocorticoids [Response to Letter].","authors":"XueWei Zhang, Evan Jin, Jinlei Li","doi":"10.2147/JPR.S523930","DOIUrl":"https://doi.org/10.2147/JPR.S523930","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1009-1010"},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diaphragm Fatigue Does Not Impact Breathing Mechanics or Function in People with Chronic Low Back Pain.","authors":"Ulrike H Mitchell, Lindsey T Robinson, Jared Brinkman, Dustin A Bruening, Anton E Bowden, Steven P Allen","doi":"10.2147/JPR.S496917","DOIUrl":"10.2147/JPR.S496917","url":null,"abstract":"<p><strong>Background and objective: </strong>The diaphragm is an important respiratory muscle that also plays a crucial role in developing intra-abdominal pressure and assisting in spinal stability. Chronic low back pain (CLBP) is a complex musculoskeletal condition and has been associated with respiratory problems and altered breathing mechanics. The purpose of this comparative cross-sectional study is to investigate whether diaphragm fatigue affects breathing mechanics and function in individuals with CLBP.</p><p><strong>Methods: </strong>Volunteers were recruited between the ages of 35-65 years old with and without CLBP. Participants performed 30 minutes of exercises intended to fatigue the diaphragm. The following respiratory parameters were measured: Breathing mechanics (chest and abdominal movement and respiratory rate), diaphragm function (forced expiratory volume in 1 second (FEV1) using a handheld spirometer), and diaphragm movement as measured by sub-diaphragm (L1 to diaphragm domes) volume changes at the end of exhalation and inhalation using MRI scans.</p><p><strong>Results: </strong>A total of 36 participants were recruited (n = 21M; n = 15F), with 18 participants suffering from CLBP (n = 10M; 8F) and 18 participants serving as a comparison group (n = 11M; n = 7F). There were no differences in breathing mechanics, diaphragm function or excursion (volumetrics) between people with and without CLBP after 30 minutes of exercises intended to fatigue the diaphragm.</p><p><strong>Conclusion: </strong>The lack of differences suggests that the diaphragm, regardless of its fatigue status as a spinal stabilizer, will not relinquish or weaken its function as a breathing muscle, though it may be less effective as a spinal stabilizer. Individuals with chronic or recurrent low back pain might therefore be more susceptible to subsequent pain flare-ups than non-symptomatic individuals. A potential clinical implication of these findings is that incorporating diaphragmatic breathing exercises to enhance diaphragm function may offer an effective treatment option for patients with CLBP.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"963-974"},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectories of mHealth-Tracked Mental Health and Their Predictors in Female Chronic Pelvic Pain Disorders.","authors":"Emily L Leventhal, Nivedita Nukavarapu, Noemie Elhadad, Suzanne R Bakken, Michal A Elovitz, Robert P Hirten, Jovita Rodrigues, Matteo Danieletto, Kyle Landell, Ipek Ensari","doi":"10.2147/JPR.S499102","DOIUrl":"10.2147/JPR.S499102","url":null,"abstract":"<p><strong>Background: </strong>Female chronic pelvic pain disorders (CPPDs) affect 1 in 7 women worldwide and are characterized by psychosocial comorbidities, including a reduced quality of life and 2-10-fold increased risk of depression and anxiety. Despite its prevalence and morbidity, CPPDs are often inadequately managed with few patients experiencing relief from any medical intervention. Characterizing mental health symptom trajectories and lifestyle predictors of mental health is a starting point for enhancing patient self-efficacy in managing symptoms. Here, we investigate the association between mental health, pain, and physical activity (PA) in females with CPPD and demonstrate a method for handling multi-modal mobile health (mHealth) data.</p><p><strong>Methods: </strong>The study sample included 4270 person-level days and 799 person-level weeks of data from CPPD participants (N=76). Participants recorded PROMIS global mental health (GMH) and physical functioning and pain weekly for 14 weeks using a research mHealth app, and moderate-to-vigorous PA (MVPA) was passively collected via activity trackers.</p><p><strong>Data analysis: </strong>We used penalized functional regression (PFR) to regress weekly GMH-T (GMH-T) on MVPA and weekly pain outcomes while adjusting for baseline measures, time in study, and the random intercept of the individual. We converted 7-day MVPA data into a single smooth using spline basis functions to model the potential non-linear relationship.</p><p><strong>Results: </strong>MVPA was a significant, curvilinear predictor of GMH-T (F=18.989, p<0.001), independent of pain measures and prior psychiatric diagnosis. Physical functioning was positively associated with GMH-T, while pain was negatively associated with GMH-T (B=2.24, B<i>=-</i>1.16, respectively; p<0.05).</p><p><strong>Conclusion: </strong>These findings suggest that engaging in MVPA is beneficial to the mental health of females with CPPD. Additionally, this study demonstrates the potential of ambulatory mHealth-based data combined with functional models for delineating inter-individual and temporal variability.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"899-913"},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethink of the New Treatment for Refractory Painful Diabetic Peripheral Neuropathy [Letter].","authors":"Yuhao Wang, Yihui Zhang, Jueying Chen","doi":"10.2147/JPR.S518245","DOIUrl":"https://doi.org/10.2147/JPR.S518245","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"897-898"},"PeriodicalIF":2.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on 'Treatment of Painful Diabetic Neuropathy with 10 kHz Spinal Cord Stimulation: Long-Term Improvements in Hemoglobin A1c, Weight, and Sleep Accompany Pain Relief for People with Type 2 Diabetes' [Letter].","authors":"Hui Li, Xinxin Luo, Juntong Liu","doi":"10.2147/JPR.S519228","DOIUrl":"https://doi.org/10.2147/JPR.S519228","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"929-930"},"PeriodicalIF":2.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Nonsurgical Neurolytic Procedures for Neuropathic Pain.","authors":"Mayank Gupta, Rany T Abdallah, Alaa Abd-Elsayed, Krishnan Chakravarthy, Miles Day, Timothy Deer, Sudhir Diwan, Nebojsa Nick Knezevic, Neel D Mehta, Michael E Schatman, Amol Soin, Peter Staats","doi":"10.2147/JPR.S491330","DOIUrl":"https://doi.org/10.2147/JPR.S491330","url":null,"abstract":"<p><strong>Introduction: </strong>Ideally, a physical or chemical nonsurgical neurolytic procedure provides targeted neurolysis to relieve pain for a suitable length of time without causing complications. This narrative review focuses on five nonsurgical neurolytic procedures that are well-established and well-documented in the literature for the treatment of refractory neuropathic pain and peripheral neuropathies, in particular: two physical nonsurgical neurolytic techniques (cryoablation and radiofrequency ablation) and three chemoneurolytic agents (alcohol injection, phenol injection, and a high-concentration capsaicin 8% topical system).</p><p><strong>Methods: </strong>Using the definition of nonsurgical physical and chemical neurolytic procedures for neuropathic pain, a focused literature search of the PubMed database for English-language, human studies published through July 2024 included, but was not limited to, the following search terms: \"neuropathic pain\" AND \"cryoablation\", \"cryoneurolysis\", \"radiofrequency ablation\", \"alcohol neurolysis\", \"alcohol injection\", \"phenol neurolysis\", \"phenol injection\", \"chemoneurolysis\", \"topical capsaicin\", and \"TRPV1.\" While attempts were made to identify prospective clinical trials for each type of neurolytic procedure, information regarding the conduct and safety and efficacy of some of these nonsurgical neurolytic procedures was primarily limited to case studies and anecdotal evidence.</p><p><strong>Results: </strong>The risk benefit basis of each technique is discussed, and recommendations for proper use based on the literature are summarized. Most techniques require ultrasound or fluoroscopy guidance. Pain relief typically ranges from 3 to 12 months, with repeat neurolytic procedures often required to maintain suitable levels of pain relief.</p><p><strong>Conclusion: </strong>The authors provide their insights as to the best utilization of these identified nonsurgical physical and chemoneurolytic procedures for the treatment of refractory neuropathic pain in different patient populations based on neural targets. Together, these five nonsurgical neurolytic techniques provide patients and physicians with a variety of options for the treatment of refractory neuropathic pain.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"879-895"},"PeriodicalIF":2.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Ultrasound Imaging Reveals Activation Properties of Clinical Spinal Cord Stimulation Therapy Programming.","authors":"Koeun Lim, Sean J Slee, Andrew Kibler, Steven Falowski, Kasra Amirdelfan","doi":"10.2147/JPR.S502432","DOIUrl":"10.2147/JPR.S502432","url":null,"abstract":"<p><strong>Objective: </strong>Spinal cord stimulation (SCS) therapy is an established treatment for chronic neuropathic pain, but methodological limitations have prohibited detailed investigation of activation patterns it produces in the SC. Functional ultrasound imaging (fUS) is an emerging technology that monitors local hemodynamic changes in the brain with high sensitivity and spatiotemporal resolution that are tightly coupled to neural functional activity. In this study, fUS was used to investigate neuromodulation patterns produced by clinical SCS paradigms in an ovine model that enabled testing with implanted clinical hardware.</p><p><strong>Materials and methods: </strong>Activation of local superficial dorsal horn (SDH) regions during SCS therapy was evaluated using fUS to detect hemodynamic changes in spinal blood volume (∆SBV). Standard SCS leads were percutaneously implanted midline overlying the dura of the exposed cord (T12-L1) to enable stimulation and recording evoked compound action potentials (eCAPs). Hemodynamic activation patterns were mapped across two vertebral segments at amplitudes between 100-200% eCAP threshold for conventional tonic, multiphase, burst, high frequency and multi-frequency SCS paradigms.</p><p><strong>Results: </strong>SCS stimulation resulted in significant activation of the SDH in differing patterns across two vertebral segments. The magnitude and volume of ∆SBV increased at higher amplitudes and was typically maximal in the SDH regions underlying the active electrodes. Therapy mode significantly influenced total area and depth of ∆SBV. Multiphase therapy produced the largest area of ∆SBV followed by multi-frequency and other SCS modes. Multiphase therapy also produced the greatest depth of ∆SBV followed by multi-frequency and burst therapies.</p><p><strong>Conclusion: </strong>This work demonstrates that fUS can effectively measure SCS neural response patterns in the pain processing laminae of a large animal model implanted with a clinical SCS system. Hemodynamic responses in the SC varied significantly across SCS therapy modes, with multiphase stimulation providing a greater area of coverage and depth of response versus other common stimulation types.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"849-867"},"PeriodicalIF":2.5,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomogram for Predicting Severe Abdominal Pain During Percutaneous Radiofrequency Ablation for Hepatocellular Carcinoma: A Retrospective Study.","authors":"Jin-Ming Tian, Jianan Zhang, Hang Liu, Fuming Wang, Qing-Song Yang, Rong Luo, Ji-Jin Yang","doi":"10.2147/JPR.S506099","DOIUrl":"https://doi.org/10.2147/JPR.S506099","url":null,"abstract":"<p><strong>Objective: </strong>To develop and validate a nomogram for identification of hepatocellular carcinoma (HCC) patients unsuitable for percutaneous radiofrequency ablation (RFA) due to severe abdominal pain.</p><p><strong>Methods: </strong>In this retrospective study, 530 patients with HBV-HCC underwent RFA between February, 2014, and April, 2024, and treated in the affiliated hospital of Changhai Hospital, Naval Medical University. Patients were divided into a modeling group (373 cases) and a validation group (157 cases) at a 7:3 ratio. Pain severity during the heating process of the radiofrequency ablation system was assessed using the Visual Analog Scale (VAS). Logistic regression was used to determine risk factors for severe pain, based on which a nomogram was developed.</p><p><strong>Results: </strong>Key predictors of severe abdominal pain included tumor distance to capsule <1cm, tumor distance to portal vein <1cm, and history of transarterial chemoembolization (TACE) (<i>P</i><0.05). The nomogram showed excellent predictive performance with an AUC-ROC of 0.756 for the modeling group and 0.714 for the validation group.</p><p><strong>Conclusion: </strong>Tumor distance to capsule, tumor distance to portal vein, and TACE history are independent factors influencing severe abdominal pain during radiofrequency ablation in HBV-HCC patients. The nomogram effectively identifies HCC patients at risk of severe pain during RFA, facilitating doctors to decide on better alternative locoregional therapies.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"837-847"},"PeriodicalIF":2.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}