Journal of Pain Research最新文献

{"title":"Postoperative Sore Throat After Tracheal Intubation: An Updated Narrative Review and Call for Action.","authors":"Zheping Chen, Zhenxiang Zuo, Le Zhang, Moxuan Gong, Yuyang Ye, Yanwu Jin, Xin Zhao","doi":"10.2147/JPR.S498933","DOIUrl":"https://doi.org/10.2147/JPR.S498933","url":null,"abstract":"<p><strong>Background: </strong>Postoperative sore throat (POST) represents a common airway complication closely related to endotracheal tube (ETT), exhibiting a higher incidence following tracheal intubation compared to other airway apparatuses. Nevertheless, considering its mild and self-limiting character, POST is often overlooked. This study provides an updated narrative review on the latest perspectives regarding POST, including a comprehensive summary of its mechanisms, risk factors, clinical assessment methods, prevention and treatment strategies. Additionally, directions for future research are proposed.</p><p><strong>Methods: </strong>A comprehensive search was conducted using keywords such as \"postoperative sore throat\" and \"tracheal intubation\" in PubMed, Web of Science, and Cochrane databases from their inception to October 2024. Two groups of reviewers independently performed data search and cleaning after standard training. To address gaps in knowledge or potential biases, the literature was thoroughly screened based on established criteria, and a comprehensive synthesis, analysis, and summary of the relevant findings was conducted.</p><p><strong>Results: </strong>The precise cause of POST remains unknown, and its potential mechanism is believed to involve secondary inflammation triggered by irritation, mechanical trauma, tracheal intubation, and cuff inflation. The risk factors for POST encompass preoperative, intraoperative, and postoperative factors. Currently, effective prevention methods for POST consist of pharmacological interventions, non-pharmacological interventions, and traditional Chinese medicine (TCM) therapy. In terms of pharmacological interventions, non-steroidal anti-inflammatory drugs (NSAIDs) and steroid can effectively prevent the occurrence of POST through their anti-inflammatory properties. However, given the unavoidable side effects of medications, non-pharmacological interventions and non-invasive methods may offer greater benefits for POST and related hoarseness. For example, proficient and gentle intubation techniques can prevent mechanical injury caused by repeated intubation attempts. Currently, several studies have demonstrated the potential role of TCM in managing POST. Nonetheless, the precise mechanisms underlying its effects remain to be elucidated, and the available clinical evidence is still limited.</p><p><strong>Conclusion: </strong>Given that POST is prevalent following tracheal intubation but frequently overlooked, we advocate heightened awareness of its occurrence and progression, and recommend integrating the prevention and management of POST into routine clinical practice.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2285-2306"},"PeriodicalIF":2.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-Analysis of Randomized Controlled Trials for Electroacupuncture Treatment of Migraine.","authors":"ShiWei Song, Hao Chen","doi":"10.2147/JPR.S518294","DOIUrl":"https://doi.org/10.2147/JPR.S518294","url":null,"abstract":"<p><strong>Purpose: </strong>Numerous clinical studies have shown that patients with migraine can benefit from electroacupuncture treatment. However, there are no published systematic reviews and meta-analyses of pure electroacupuncture for migraine. Therefore, we conducted a meta-analysis to evaluate the efficacy of pure electroacupuncture as a standalone treatment for migraine patients.</p><p><strong>Patients and methods: </strong>We searched Six electronic databases. All from the inception to August 1st, 2024. In the literature, clinical investigators evaluated the efficacy and safety of electroacupuncture as the primary treatment for migraine. Researchers assessed the quality of the studies using the Cochrane Handbook for Systematic Reviews of Interventions. The Review Manager 5.4 software was used to perform statistical analysis.</p><p><strong>Results: </strong>Ten randomized controlled trials involving 1161 people were included. The meta-analysis yielded a substantial result: the application of pure electroacupuncture significantly improved the effective rate compared to the control group. In the visual analogue scale score, the present study found no significant difference between electroacupuncture and Western medicine as standalone treatments. Regarding migraine-associated symptom scores, the experimental group exhibited no superiority in comparison to the control group. Moreover, following the intervention, several significant changes were observed in the secondary outcome indicators between the two groups, including cerebral arterial blood flow velocity, the migraine attack days, the lasting time of headache remission, mean time of the headache attack, duration of the headache attack, and the migraine-specific quality of life questionnaire score, with the results proving to be statistically significant.</p><p><strong>Conclusion: </strong>The results of the analysis suggested that pure electroacupuncture is beneficial for migraine patients, but it remains difficult to obtain comprehensive data. Our study is supported by evidence of low to moderate quality. It is necessary to further confirm the efficacy of pure electroacupuncture for migraine with higher-quality clinical research.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2321-2333"},"PeriodicalIF":2.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized, Sham-Controlled Trial on the Efficacy and Safety of Electroacupuncture for Lumbar Disc Herniation with Radiculopathy: Rationale and Study Protocol.","authors":"Yuwei Yang, Liting Liu, Lixia Yuan, Xiaoya Liu, Haoying Ding, Xu Zhou, Qianan Cao","doi":"10.2147/JPR.S512711","DOIUrl":"https://doi.org/10.2147/JPR.S512711","url":null,"abstract":"<p><strong>Introduction: </strong>Electroacupuncture, validated in preclinical studies, is a promising alternative approach for lumbar disc herniation with radiculopathy (LDHR). This trial aims to evaluate the efficacy and safety of electroacupuncture in patients with LDHR.</p><p><strong>Methods: </strong>This randomized, single-blind, sham-controlled trial will enroll 170 participants diagnosed with LDHR and who present Numerical Rating Scale (NRS) scores ≥4 for both lower back and leg pain. Participants will be allocated at a 1:1 ratio to receive either electroacupuncture or sham electroacupuncture (superficial needling at nonacupoint sites). The sample size was determined based on pilot study data and power calculations. Treatments will be administered three times weekly over 8 weeks (24 sessions total), with blinding maintained throughout. An 18-week noninterventional follow-up will be extended to address the knowledge gap regarding the durability of neuromodulatory effects of electroacupuncture. The following outcomes will be evaluated: 1) primary outcome: the proportion of responders achieving ≥ a 2-point NRS reduction in both lower back and leg pain from baseline at weeks 8 and 24; 2) secondary outcomes: changes from baseline at weeks 4, 8, 16, and 24 in the intensity of low back pain and leg pain, level of disability, severity of depression and anxiety, sleep quality, as well as the incidence of lumbar spine surgery and the proportion of use of analgesics at weeks 8 and 24; and 3) safety outcome: the incidence of adverse events. The efficacy outcomes will be analyzed based on the full analysis set with the modified intention-to-treat principle. Treatment effects will be estimated using a generalized linear mixed-effects model for repeated measures. Blinding validity will be assessed via James's and Bang's indices.</p><p><strong>Conclusion: </strong>This rigorously designed randomized controlled trial will generate confirmatory evidence to support the efficacy and safety of electroacupuncture in the treatment of LDHR.</p><p><strong>Trial registration no: </strong>NCT06611332 (https://clinicaltrials.gov/study/NCT06611332).</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2307-2319"},"PeriodicalIF":2.5,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation Factors Mediate Association of Muscle Mass and Migraine: NHANES 1999-2004 and Mendelian Randomization.","authors":"Chunyan Jia, Hong Li, Shaonan Yang, Yue Liu, Lijun Liu, Aijun Ma, Liang Zhang","doi":"10.2147/JPR.S516748","DOIUrl":"https://doi.org/10.2147/JPR.S516748","url":null,"abstract":"<p><strong>Purpose: </strong>The relationship between adipose-muscle distribution and its effect on migraine remains unclear. This study examines the association between muscle mass and migraine prevalence and evaluates potential mediation by systemic inflammatory biomarkers.</p><p><strong>Methods: </strong>Using a cross-sectional design, we analyzed data from 10,400 participants in the National Health and Nutrition Examination Survey (NHANES) (1999-2004). The association between appendicular lean mass normalized to body mass index (ALM/BMI) and migraine prevalence was evaluated through weighted logistic regression and subgroup analyses. Mediation analyses were conducted to examine the potential mediating roles of inflammatory markers, including C-reactive protein (CRP), white blood cell count (WBC), and neutrophils, in the relationship between ALM/BMI and migraine prevalence. Genetic causality was investigated via two-sample Mendelian randomization (MR) using genome-wide association study (GWAS) data.</p><p><strong>Results: </strong>20% of total participants reported migraines. A higher ALM/BMI ratio was inversely associated with migraine after full adjustment (OR = 0.243; 95% CI: 0.122-0.487, <i>p</i> < 0.001). Vigorous activity reduced migraine susceptibility by 24% (OR = 0.760; 95% CI: 0.663-0.872, <i>p</i> < 0.001). CRP, WBC and neutrophils mediated 2.0% (<i>p</i> = 0.024), 3.1% (<i>p</i> = 0.011), and 2.8% (<i>p</i> = 0.019) of the ALM/BMI-migraine association, respectively. The inverse-variance weighted approach (IVW) in MR analysis indicated that higher basal metabolic rate (BMR) reduced migraine risk (OR = 0.996, 95% CI: 0.992-0.998, <i>p</i> = 0.004) and headache risk (OR = 0.998, 95% CI: 0.997-1.000, <i>p</i> = 0.018). Fat-free mass also exhibited protective effects on migraines (OR = 0.997, 95% CI: 0.994-1.000, <i>p</i> = 0.045).</p><p><strong>Conclusion: </strong>Increased muscle mass is associated with reduced migraine risk, partially mediated by attenuating systemic inflammation. These findings provide us with an approach of health management to prevent migraines.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2269-2283"},"PeriodicalIF":2.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Prevalence of Small-Fiber Neuropathy in Patients with Tarlov Cysts: Toward a More Comprehensive Clinical Understanding.","authors":"Mieke Hulens, Peter Zajonc, Frans Bruyninckx, Ricky Rasschaert, Peter De Mulder, Chris Bervoets, Wim Dankaerts","doi":"10.2147/JPR.S513705","DOIUrl":"https://doi.org/10.2147/JPR.S513705","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the prevalence of small-fiber neuropathy (SFN) and the clinical characteristics of patients with Tarlov cysts (PTCs), focusing on symptoms related to SFN and increased cerebrospinal pressure.</p><p><strong>Patients and methods: </strong>In this retrospective study, 126 surveys assessing symptoms in women (30-69 years) with Tarlov cysts (TCs) ≥ 7 mm seeking treatment for chronic back, pelvic or leg pain and skin biopsy results from 75 patients assessing intraepidermal nerve fiber density (IENFD) were reviewed.</p><p><strong>Results: </strong>IENFD < 5th percentile was documented in 80% of PTCs according to the normative reference data of Collongues et al and 72% according to the worldwide dataset of Lauria et al Questionnaires revealed high incidences of neuropathic pain (80%), allodynia (76%), pain while sitting (93%), anal sphincter (11%) and urinary sphincter (66%) problems, persistent genital arousal (27%), and restless legs (54%). Autonomic dysfunctions included early satiety (41%), bladder (93%) and bowel (88%) dysfunction, increased sweating (51%), and Raynaud's phenomenon (45%). Other symptoms potentially associated with increased cerebrospinal fluid pressure (CSFP) were headaches (57%), fatigue (86%), cognitive issues (86%), and pulsatile tinnitus (59%).</p><p><strong>Conclusion: </strong>This study revealed a high prevalence of SFN in PTCs (72-80%). Although the TCs may not cause radicular pain in the corresponding dermatomes directly, individuals with TCs frequently report a range of symptoms that have previously been linked to symptomatic TCs, including bladder, bowel, sphincter, and sexual symptoms, as well as local pain. Additionally, seemingly unrelated symptoms, such as headaches, fatigue, cognitive difficulties, neuropathic pain localized in other parts of the body, and autonomic dysfunctions, are commonly reported. These symptoms may be associated with elevated CSFP within the nerve root sheath. Elevated pulsatile CSFP underlies the formation of TCs at the dorsal root ganglion and may gradually contribute to small-fiber dysfunction by irritating, compressing and damaging small nerve fibers within the dorsal root ganglion.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2241-2263"},"PeriodicalIF":2.5,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspective Articles as Catalysts for Innovation: Addressing Critiques on Traditional Chinese Rehabilitation Exercise for Myofascial Pain [Response to Letter].","authors":"Xueen Liu, Jiale Zhang","doi":"10.2147/JPR.S534896","DOIUrl":"https://doi.org/10.2147/JPR.S534896","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2265-2267"},"PeriodicalIF":2.5,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Stratification for Postoperative Opioid Induced Respiratory Depression: A Retrospective Case-Control Analysis of Existing Validated Tools.","authors":"Sam Hutcheson, Aimee Pehrson, Robert B Gassert, Ethan Guffey, Paul C Shanahan, Laura Sisk, Samuel Patton, Che Antonio Solla","doi":"10.2147/JPR.S495181","DOIUrl":"https://doi.org/10.2147/JPR.S495181","url":null,"abstract":"<p><strong>Purpose: </strong>Postoperative opioid-induced respiratory depression (POIRD) is a preventable perioperative cause of morbidity and mortality. A validated POIRD risk stratification tool could reduce these complications. 3 pre-existing validated opioid tools; and specific risk factors identified from these tools; were examined in this retrospective case-control study to determine if they could assess POIRD risk in patients discharged to hospital floors from the Post-Anesthesia Care Unit (PACU).</p><p><strong>Patients and methods: </strong>Our dataset includes 126 matched patients who underwent surgery at the University of Tennessee Medical Center from January 2019 to December 2021. All patients that were related to active traumas or burns were excluded from this study. Escalation of care secondary to respiratory failure (an increase in respiratory support with movement to an intensive care unit/stepdown unit or patient expiration secondary to respiratory failure) with and without naloxone administration was the primary endpoint; with the subgroup that received naloxone being the surrogate POIRD endpoint. Escalation of care secondary to respiratory failure; regardless of naloxone use; was a secondary endpoint.</p><p><strong>Results: </strong>There was no association between the 3 opioid tools evaluated with the POIRD surrogate endpoint or escalation of care. Bipolar disorder (OR 3.68; 95% CI 1.11-9.56) and a history of substance abuse (OR 26.33; 95% CI 5.18-119.02) were significant risk factors that contributed to escalation of care secondary to respiratory failure. A history of substance abuse was found to have a significant association with escalation of care secondary to respiratory failure with naloxone administration (OR=6.886; 95% CI 2.02-23.56).</p><p><strong>Conclusion: </strong>While we were unable to identify a tool to stratify POIRD risk; patients with bipolar disorder and a history of substance abuse are at an increased risk of postoperative respiratory failure requiring escalation of care; with a history of substance abuse being associated with POIRD.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2233-2240"},"PeriodicalIF":2.5,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12047283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiofrequency for Chronic Knee Pain: A Literature Review.","authors":"Chao Shang, Ning Sun, Zixu Lv, Donghua Yin, Chunlin Feng","doi":"10.2147/JPR.S512813","DOIUrl":"https://doi.org/10.2147/JPR.S512813","url":null,"abstract":"<p><strong>Objective: </strong>This review aimed to explore the current applications of radiofrequency (RF) therapy in managing chronic knee pain and to compare different treatment strategies.</p><p><strong>Methods: </strong>A comprehensive review of recent literature was conducted, concentrating on variations in target selection, guidance techniques, and treatment parameters that influence therapeutic outcomes.</p><p><strong>Results: </strong>RF therapy is a minimally invasive and effective treatment for chronic knee pain, providing faster recovery compared with traditional interventions. However, differences in treatment options can lead to significant variability in the efficacy and safety.</p><p><strong>Conclusion: </strong>A thorough understanding of the distinct characteristics of various RF therapy strategies is required for optimizing chronic knee pain management. Future research should emphasize systematic evaluation of these approaches to refine clinical practice and establish evidence-based pain management protocols.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2203-2213"},"PeriodicalIF":2.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Efficacy and Complications Between Biportal Endoscopic Lumbar Interbody Fusion and Minimally Invasive Transforaminal Lumbar Interbody Fusion for Lumbar Degenerative Diseases: A Systematic Review and Meta-Analysis.","authors":"Qianqin Hu, Keyi Xiao, Jin-Niang Nan, Shang-Wun Jhang, Chien-Min Chen, Guang-Xun Lin","doi":"10.2147/JPR.S472975","DOIUrl":"https://doi.org/10.2147/JPR.S472975","url":null,"abstract":"<p><strong>Objective: </strong>To effectuate a comprehensive juxtaposition of the clinical implications, incidence of complications, and successful fusion rates observed in the context of biportal endoscopic lumbar interbody fusion (BE-LIF) and minimally invasive transforaminal lumbar interbody fusion (MI-TLIF).</p><p><strong>Methods: </strong>The present research initiative involved an exhaustive exploration of pertinent scholarly literature in renowned databases, which lasted until April 2023. The evaluative framework encompassed a diverse array of parameters, including but not limited to operation time, hospitalization, quantification of estimated blood loss, the assessment of outcomes via the application of the Visual Analog Scale (VAS) to gauge pain intensity, and the utilization of the Oswestry Disability Index (ODI) to measure functional impairment.</p><p><strong>Results: </strong>The current meta-analysis included ten studies with a total of 736 participants. In comparison of the BE-LIF and MI-TLIF techniques, no substantial differences were observed in the parameters studied, included VAS for leg pain (P > 0.05), as well as the assessment of complication rates (7.76% versus 7.97%; P = 0.71) and fusion rates (89.59% versus 88.60%; P = 0.90). However, the early postoperative VAS for back pain (P < 0.0001) and the early postoperative ODI score (P = 0.007) were significantly lower in the BE-LIF group than in the MI-TLIF group. Additionally, a significant difference in blood loss was observed (P < 0.0001), with less blood loss in the BE-LIF group compared to the MI-TLIF group. Furthermore, the complex surgical procedure of BE-LIF resulted in a longer duration of surgery (P = 0.02) but shorter hospitalization compared with MI-TLIF (P < 0.0001).</p><p><strong>Conclusion: </strong>Within the context of the management of lumbar degenerative diseases, BE-LIF surgery exhibits clinical effectiveness and incidence of complications comparable to MI-TLIF. In contrast to MI-TLIF, BE-LIF offers distinctive merits, including reduced blood loss, abbreviated hospitalization durations, expedited relief from postoperative back pain, and an accelerated trajectory towards functional recuperation.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2215-2231"},"PeriodicalIF":2.5,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Relationship Between Psychosocial Factors and Neck Pain: A Two-Sample Mendelian Randomization Study.","authors":"Haibo Liang, Qihang Wu, Shu Yang, Shuhao Zhang, Jiansen Miao, Haiming Jin, Xiangyang Wang","doi":"10.2147/JPR.S508287","DOIUrl":"https://doi.org/10.2147/JPR.S508287","url":null,"abstract":"<p><strong>Purpose: </strong>Neck pain (NP) is a multifactorial disorder that leads to severe disability. This study aimed to investigate whether potential risk factors have a causal effect on NP at the genetic level using a two-sample Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>Summary-level data for potential risk factors, including distress, anxiety disorder, depression, mood, sleep disorder, loneliness, education, alcohol consumption, smoking, time spent using the computer, and physical activity, as well as NP, were obtained from multiple large-scale Genome-Wide Association Studies (GWAS). Instrumental variables (IVs) were extracted from these datasets. We employed inverse variance weighting (IVW), weighted median, and MR-Egger regression methods to assess causal effects. Heterogeneity was evaluated using MR-Egger regression and IVW, while horizontal pleiotropy was assessed using MR-PRESSO analysis and MR-Egger regression.</p><p><strong>Results: </strong>The IVW results showed that major depressive disorder (OR = 1.51, 95% CI: 1.15, 1.98, p = 3.40×10^-3) and experiencing mood swings (OR = 2.73, 95% CI: 1.57, 4.75, p = 3.86×10^-4) were positively associated with NP and years of schooling (OR = 0.504, 95% CI: 0.410, 0.619, p = 6.55×10^-11) was negatively associated with NP. Additionally, loneliness (OR = 16.0, 95% CI: 1.29-198, p = 0.0307) showed a suggestive association with NP. As for the other factors we did not find a clear causal relationship (All p-values > 0.05).</p><p><strong>Conclusion: </strong>This two-sample MR study provides genetic evidence supporting a causal relationship between major depressive disorder, mood swings, and years of schooling with NP, while loneliness showed a potential association. These findings highlight the critical role of psychosocial factors, such as depression, mood swings, and education level, in the prevention and management of NP. Our results may offer new insights for clinicians to develop targeted intervention strategies aimed at reducing the incidence of NP.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2191-2201"},"PeriodicalIF":2.5,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12039842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}