Journal of Pain Research最新文献

{"title":"Clinical Efficacy of Electroacupuncture in the Treatment of Chronic Neck Pain: A Randomized Clinical Trial.","authors":"Wenting Li, Xiaoyang Liu, Jiahui Lin, Jianpeng Huang, Sheng Li, Nenggui Xu, Wenbin Fu, Jianhua Liu","doi":"10.2147/JPR.S515679","DOIUrl":"10.2147/JPR.S515679","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic neck pain (CNP) is a common but challenging symptom in clinical practice. Acupuncture is widely used in alleviating the symptoms of CNP. The main objective of this study was to evaluate the efficacy and safety of electroacupuncture (EA) in patients with CNP and to quantify the specific effects of EA by controlling for placebo effects.</p><p><strong>Patients and methods: </strong>A randomized sham-controlled trial was conducted at the outpatient departments of single hospital in China from November 2019 to November 2020 and a total of 105 participants with CNP were enrolled. Participants were randomly assigned (1:1:1) to the EA group, sham electroacupuncture (SEA) group and waiting list (WL) group. The primary outcome was change in the Northwick Park Neck Pain Questionnaire (NPQ). Secondary outcomes included McGill Pain Questionnaire (MG), visual analogue scale (VAS) and pain threshold (PT).</p><p><strong>Results: </strong>This randomized clinical trial included 98 patients. The EA group demonstrated a greater reduction in NPQ scores compared to the SEA group after 10 sessions (-7.2564, 95% CI=-12.2875 to -2.2253, <i>P</i>=0.0054) and at 3-month follow up (-7.0090, 95% CI=-10.5039 to -3.5140, <i>P</i>=0.0002). After 10 sessions, the EA and SEA groups exhibited greater reductions in NPQ scores compared to the WL group (EA vs WL: <i>P</i> <b><</b>0.001, [95% CI=6.570 to 15.503]; SEA vs WL: <i>P</i>=0.027, [95% CI=0.578 to 9.580]). However, the EA group achieved clinically significant NPQ improvements (>25%), whereas the SEA group failed to meet this criterion.</p><p><strong>Conclusion: </strong>This randomized clinical trial found that, in patients with CNP, EA significantly improved the symptoms compared with SEA and WL groups both immediately and cumulatively (at 5 weeks), and these benefits persisted through week 17. These comparisons demonstrated that EA's clinical benefits exceeded placebo effects.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2909-2922"},"PeriodicalIF":2.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic Study on the Therapeutic Effects of Juanbi Lijieqing Formula in a Rat Model of Gouty Arthritis with Hyperuricemia.","authors":"Yifan Lu, Chengyin Lu, Gonghui Jian, Hui Xiong, Yang Shu","doi":"10.2147/JPR.S517711","DOIUrl":"10.2147/JPR.S517711","url":null,"abstract":"<p><strong>Background: </strong>This study evaluated the therapeutic effects and underlying mechanisms of Juanbi Lijieqing Formula (JBLJQF) in a rat model of gouty arthritis with hyperuricemia.</p><p><strong>Methods: </strong>Forty-two rats were randomly assigned to seven groups: control, model, etoricoxib, benzbromarone, and low-, medium-, and high-dose JBLJQF. General condition, joint swelling, behavioral performance, biochemical markers, and histopathology were assessed. Urate Anion Transporter 1(URAT1) expression was examined via immunofluorescence and Western blot.</p><p><strong>Results: </strong>JBLJQF improved general condition, reduced joint swelling, and alleviated kidney damage. Medium- and high-dose groups showed enhanced pain threshold and locomotor activity. Serum uric acid, TNF-α, and IL-1β levels were significantly decreased. URAT1 expression was downregulated, suggesting reduced renal urate reabsorption.</p><p><strong>Conclusion: </strong>JBLJQF exerts anti-inflammatory, uric acid-lowering, and organ-protective effects in gouty arthritis with hyperuricemia, highlighting its potential for clinical application.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2865-2877"},"PeriodicalIF":2.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Brain Functional Connectivity and Neurometabolite Correlations in Orofacial Chronic Pain with Central Sensitization.","authors":"Makoto Terumitsu, Yuhei Takado, Ken-Ichi Fukuda, Eisuke Kato, Sei Tanaka, Khin Khin Tha","doi":"10.2147/JPR.S507893","DOIUrl":"10.2147/JPR.S507893","url":null,"abstract":"<p><strong>Purpose: </strong>Central sensitization (CS) is one of the causes of refractory chronic orofacial pain (COFP). Chronic pain reportedly alters resting-state functional connectivity (FC) in the brain. The salience network (SN) overlaps with brain regions involved in chronic pain. Moreover, excitatory and inhibitory neural activities can alter FC. This study investigated the correlations between FC of the SN and other neural circuits, neurometabolites in anterior cingulate cortex (ACC), and CS Inventory (CSI) scores.</p><p><strong>Patients and methods: </strong>Participants were 21 COFP patients and 21 healthy sex- and age-matched volunteers. We conducted a combined study of CSI scores, resting-state functional magnetic resonance imaging, and proton magnetic resonance spectroscopy of ACC.</p><p><strong>Results: </strong>FC between the nucleus accumbens within the mesolimbic system and SN regions was significantly stronger in patients compared with that in controls. In patients, the results revealed positive correlations between CSI scores and FC in four pairs of regions: ACC-right putamen and ACC-right globus pallidus, left insula-right putamen, and right anterior supramarginal gyrus-right lateral prefrontal cortex. Regarding correlations between neurometabolites in ACC and FC between ACC and other cortical regions, the results revealed that bilateral ACC-anterior insula FC was negatively correlated with glutamate, glutamine, and glutathione. Additionally, aspartate, an N-methyl-D-aspartic acid receptor agonist, was negatively correlated with FC of ACC-right parietal cortex in the default mode network. Regarding FC of bilateral ACC-posterior parietal cortex in the frontoparietal network, FC on the right side was positively correlated with glutathione associated with excitatory neuronal activity, whereas that on the left side was negatively correlated with gamma-aminobutyric acid / total creatine associated with inhibitory neural activity.</p><p><strong>Conclusion: </strong>Connectivity within the SN, and between the SN and the mesolimbic system and other networks, may be involved in CS in COFP. Neurometabolites in the ACC may modulate FC linked to the ACC.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2849-2863"},"PeriodicalIF":2.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Racial Disparities in Chronic Pain Management.","authors":"Anthony J Vargas, Leah Tobey-Moore, Geoffrey M Curran, Rania Elkhateb, Kevin W Sexton, Brett J Bailey, Corey Nagel, Johnathan H Goree","doi":"10.2147/JPR.S493664","DOIUrl":"10.2147/JPR.S493664","url":null,"abstract":"<p><strong>Introduction: </strong>Addressing racial disparities in chronic pain management referrals and prescribing is critical for ensuring equitable healthcare outcomes. Understanding these disparities is crucial for developing effective, patient-centered treatment strategies.</p><p><strong>Patients and methods: </strong>A cross-sectional retrospective study of 19,919 patients diagnosed with chronic non-cancer pain between 7/1/2020 and 7/1/2022 was conducted at a major academic medical center. Patients' demographics, pain types, and treatment modalities were analyzed using chi-square tests and logistic regression models to evaluate racial differences in pain management referrals and opioid prescriptions.</p><p><strong>Results: </strong>Non-Hispanic Black (NHB) and Hispanic patients had significantly lower odds of receiving interventional pain (Odds Ratio [OR] = 0.72 and 0.40, respectively) and neurosurgical referrals (OR = 0.66 and 0.49, respectively) compared to Non-Hispanic White (NHW) patients. Conversely, NHB patients were more likely to receive orthopedic surgery (OR = 1.40) and physical therapy referrals (OR = 1.16). Additionally, both NHB and Hispanic patients had lower odds of receiving opioid therapy (OR = 0.75 and 0.47, respectively) compared to NHW patients.</p><p><strong>Conclusion: </strong>This study highlights significant racial disparities in chronic pain management, with NHB and Hispanic patients receiving fewer referrals to specialist care and lower opioid prescription rates compared to NHW patients. Strategies to address these disparities include provider education on implicit bias, cultural sensitivity training, and ensuring equitable access to healthcare resources. Further research is needed to explore the root causes of these disparities and develop targeted interventions to improve healthcare equity for all patients.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2901-2908"},"PeriodicalIF":2.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior Percutaneous Endoscopic Cervical Discectomy for Single-Segment Cervical Spondylotic Radiculopathy: A Retrospective Study with Minimum 3-Year Follow-Up.","authors":"Xiangbin Wang, Tao Li, Yong Li, Yubin Long","doi":"10.2147/JPR.S519127","DOIUrl":"10.2147/JPR.S519127","url":null,"abstract":"<p><strong>Background: </strong>Posterior percutaneous endoscopic cervical discectomy (P-PECD) has been increasingly used for cervical spondylotic radiculopathy (CSR), while few studies have reported on its medium-long-term outcomes. This study aims to investigate the medium-long-term efficacy and imaging findings of P-PECD in the treatment of single-segment CSR.</p><p><strong>Methods: </strong>The data of 51 patients with single-segment CSR treated with P-PECD were retrospectively analyzed. Efficacy was evaluated using visual analog scale (VAS) scores of neck and arm, Japanese Orthopaedic Association (JOA) score, neck disability index (NDI), and modified Macnab criteria. Radiologic parameters were measured before and after the operation, including cervical Cobb angle, range of motion (ROM), intervertebral space height, as well as horizontal and angular displacement at the operative level.</p><p><strong>Results: </strong>The VAS scores of neck and arm, JOA score, and NDI were significantly improved postoperatively compared with those before the operation, and the differences were statistically significant (<i>P <</i>0.05). Based on the modified Macnab criteria at the final follow-up, 94.12% showed excellent to good outcomes. Postoperatively, the cervical Cobb angle was 10.63 ± 1.79^°, ROM was 6.33 ± 1.11^°, the intervertebral space height was 4.63 ± 0.85 mm, horizontal and angular displacement at the operative level were 0.88 ± 0.68 mm and 4.25 ± 1.04^°, respectively, and there were no significantly changed at the final follow-up.</p><p><strong>Conclusion: </strong>P-PECD for single-segment CSR has the advantages of less trauma, less bleeding, a low complication rate, faster postoperative recovery, and less impact on cervical mobility and stability, which has excellent medium-long-term efficacy.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2879-2888"},"PeriodicalIF":2.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture as an Adjunctive Therapy to Etoricoxib for Patients with Acute Gouty Arthritis: Protocol for a Multicenter Randomized Controlled Trial.","authors":"Yi-Ran Wang, Cun-Zhi Liu, Yan Cong, Ya-Wei Xi, Ying-Ying Xu, Bo Li, Yi Zhou, Jian-Feng Tu, Yi-Ming Fu, Wen Chen, Li-Qiong Wang, Guang-Xia Shi","doi":"10.2147/JPR.S523657","DOIUrl":"10.2147/JPR.S523657","url":null,"abstract":"<p><strong>Purpose: </strong>Acute gouty arthritis (AGA) is often managed with non-steroidal anti-inflammatory drugs. However, patients still tolerate severe pain before the analgesic takes effect. Early adjuvant analgesia is necessary in the pharmacological management of AGA. Acupuncture has the advantage of quick analgesia; nevertheless, the evidence to support the use of early-acupuncture as an adjunctive therapy for AGA is limited. This study aims to assess the efficacy of acupuncture compared with sham acupuncture on pain relief among AGA patients who are concurrently receiving etoricoxib.</p><p><strong>Patients and methods: </strong>In this multicenter, randomized, controlled trial, total 160 eligible patients with AGA will be randomly allocated into acupuncture group and sham acupuncture group in a 1:1 ratio. All patients will receive oral etoricoxib followed by 30-minute acupuncture or sham acupuncture for 1 session. The primary outcome is the change in pain intensity (Visual Analogue Scale) after the 30-minute acupuncture treatment from baseline. The secondary outcomes include tenderness of study joint, swelling of study joint, rescue medicine, credibility and expectation evaluation and blinding assessment. Adverse events will be recorded during the trial. All the patients who are randomized in this study will be included in the intention-to-treat analysis.</p><p><strong>Conclusion: </strong>The results of this study will provide evidence for acupuncture used in the treatment of acute gouty arthritis and promote clinical decisions to physicians and patients.</p><p><strong>Trial registration: </strong>The protocol has been approved by the Medical Ethical Committee of Beijing University of Chinese Medicine (2023BZYLL0103) and registered at International Traditional Medicine Clinical Trial Registry (ITMCTR2024000218; http://itmctr.ccebtcm.org.cn/zh-CN/UserPlatform/ProjectView?pid=1749b951-b101-418f-8f82-77be3c72ea00).</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2889-2900"},"PeriodicalIF":2.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12165196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cost Effectiveness Analysis of Spinal Cord Stimulation versus Conventional Medical Management for the Treatment of Low Back Pain Using Data from DISTINCT RCT and Medical Claims from a U.S. Commercial Payer Database.","authors":"Timothy Deer, Robert Heros, Keith Scarfo, Christopher Gilligan, Jessica Jameson, Julie G Pilitsis, Mehul J Desai, Thadchaigeni Panchalingam, Scott Goates, Alexander M Benison, Udoka Okaro, Steven Falowski","doi":"10.2147/JPR.S486759","DOIUrl":"10.2147/JPR.S486759","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the healthcare utilization (HCU) and costs for passive recharge burst Spinal Cord Stimulation (SCS) and conventional medical management (CMM) cohorts in patients with chronic low back pain (LBP) to a matched real-world cohort of similar indication. The null hypothesis is that SCS is equally or less cost-effective than CMM in treating LBP.</p><p><strong>Patients and methods: </strong>DISTINCT is a prospective, multi-center, randomized study. Data was collected during in-clinic visits at baseline, one, three, and six months. The DISTINCT \"completer cohort\" included 79 DISTINCT SCS patients and 55 DISTINCT CMM patients who completed the six-month visit. An external real-world cohort (n = 71) with similar characteristics to DISTINCT CMM patients was identified from a claims database (Optum's de-identified Market Clarity Data). Accessed data included healthcare resource utilization (HCU), pain-related medication usage, pain scale, and quality of life. HCU data covered physical therapy, chiropractic therapy, massage therapy, occupational therapy, acupuncture, injection treatments, radiofrequency ablation procedures, and opioid and anticonvulsant usage.</p><p><strong>Results: </strong>The DISTINCT study demonstrated superior outcomes in pain relief, function, and other symptoms with SCS compared to CMM in the treatment of persistent (at least 6 months) low back pain. DISTINCT SCS patients utilized fewer healthcare resources and incurred lower costs than DISTINCT CMM patients. Real-world CMM patients exhibited higher utilization of certain therapies, suggesting potential pre-crossover bias. SCS resulted in significant cost savings and improved quality of life compared to CMM. Including device costs, cost-effectiveness could be achieved within 2.7 years based on DISTINCT data. The real-world CMM arm used more high-priced interventional therapies, suggesting a pre-crossover bias in the CMM cohort.</p><p><strong>Conclusion: </strong>This analysis supports the long-term benefits and cost-effectiveness of SCS in managing chronic LBP compared to CMM.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2823-2838"},"PeriodicalIF":2.5,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Telemedicine-Supported Structured Exercise Program in Patients with Chronic Low Back Pain: Study Protocol for a Randomized Controlled Trial.","authors":"Yuan Feng, Chengsen Jia, Huizhen Liu, Tianjie Bao, Chongyang Wang, Zezhang Wang, Jielei Huang, Yiwen Jiang, Xiaoyi Wang, Ruishi Zhang, Yujia Zhang, Shaojun Zhang, Siyi Zhu, Chengqi He","doi":"10.2147/JPR.S518072","DOIUrl":"10.2147/JPR.S518072","url":null,"abstract":"<p><strong>Purpose: </strong>Telemedicine-based structured exercise programs have the potential to benefit patients with chronic low back pain (CLBP). However, evidence-practice gaps persist, including low exercise adherence and insufficient focus on mental health. Consequently, further research is warranted to clarify the impact of telemedicine-supported structured exercise programs on patients with CLBP.</p><p><strong>Patients and methods: </strong>This randomized controlled trial will include patients with CLBP who have not received exercise therapy in the past three months. Participants in the trial group will receive patient education, health coaching, and home-based exercise therapy via mobile health (mHealth) applications loaded with wearable device integration. Those in the control group will receive conventional treatment, comprising patient education and written instructions for home exercises. Disability including pain intensity will be assessed as primary outcomes using the Roland-Morris Disability Questionnaire (RMDQ) and the Numerical Rating Scale (NRS) at baseline, 4 weeks, and 8 weeks. Statistical analyses will depend on assumptions such as homogeneity of variance and sphericity: if met, a two-factor, three-level repeated measures analysis of variance will be used; otherwise, a linear mixed-effects model will be employed.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2809-2822"},"PeriodicalIF":2.5,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12153955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning Analysis to Identify Predictive Factors of Caudal Epidural Pulse Radiofrequency in the Treatment of Coccygodynia.","authors":"Ender Sir, Sena Aydogan, Gul Didem Batur Sir, Alp Eren Celenlioglu","doi":"10.2147/JPR.S521331","DOIUrl":"10.2147/JPR.S521331","url":null,"abstract":"<p><strong>Background: </strong>This study aims to use machine learning (ML) to explore predictive parameters related to the efficacy of caudal epidural pulsed radiofrequency (CEPRF) treatment for coccygodynia.</p><p><strong>Methods: </strong>Five different ML methods were used to predict treatment success at 6 months after CEPRF. The findings generated by these algorithms are compared with respect to the accuracy of the results.</p><p><strong>Results: </strong>Symptom duration, angular deformation and NRS at admission are the most significant factors impacting therapy success in coccygodynia patients. Success rates are obtained for relatively short symptom durations to be 71.83%, for longer periods to be 16.67%; for short durations together with no angular deformity to be 79.55%, with angular deformity to be 59.26%; and for NRS level at admission less than 8 together with angular deformity to be 91.67%, with no angular deformity to be 33.33%.</p><p><strong>Conclusion: </strong>This research reveals the potential of ML methods to improve treatment outcome prediction in coccygodynia. When a new patient is admitted, the ML-generated decision trees provide a quick and precise assessment of the possible success rate of CEPRF treatment.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2839-2848"},"PeriodicalIF":2.5,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12154530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suzetrigine Approval Breaks a 25-Year Silence: A New Era in Non-Opioid Acute Pain Management.","authors":"Olivier Sibomana, Melody Okereke, Clyde Moono Hakayuwa","doi":"10.2147/JPR.S526851","DOIUrl":"10.2147/JPR.S526851","url":null,"abstract":"<p><p>Pain management remains a critical priority in clinical practice. Meanwhile, traditional analgesics, including non-opioid and opioid medications, often pose substantial risks, including adverse effects and potential for addiction. The recent approval of Suzetrigine by the US Food and Drugs Administration (FDA) represents a pivotal advancement in non-opioid analgesia for the treatment of moderate-to-severe acute pain. Suzetrigine, a selective NaV1.8 sodium channel inhibitor, provides effective pain relief by targeting peripheral pain pathways, minimizing the risk of addiction commonly associated with opioids, and has good safety profile according to clinical trials. Given the growing concerns surrounding opioid use, Suzetrigine offers a promising therapeutic alternative in acute pain management, with future research needed to assess its long-term effectiveness in diverse populations.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2805-2808"},"PeriodicalIF":2.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}