Journal of Pain Research最新文献

{"title":"The Predictive Value and Influencing Factors of Craniocervical Flexion Test for Patients with Chronic Non-Specific Neck Pain: A Case Control Study.","authors":"Maodong Wu, Wenchao Yi, Qinglun Su, Yiming Huang, Qin Zhao, Shouguo Liu","doi":"10.2147/JPR.S482325","DOIUrl":"10.2147/JPR.S482325","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to examine the predictive value of Craniocervical Flexion Test (CCFT) scores in individuals with chronic non-specific neck pain (CNNP) and to identify factors that may affect CCFT scores.</p><p><strong>Methods: </strong>This case-control study included 73 patients with CNNP and 127 healthy controls. We assessed baseline information such as demographics, duration and frequency of CNNP onset, Neck Disability Index (NDI), and Visual Analog Scale (VAS) scores. All subjects were evaluated by the same rater for CCFT, maximal muscle strength, and endurance of the deep cervical flexors. Head and neck posture was measured using two-dimensional videography, capturing sagittal head angle (SHA), forward head angle (FHA), and protracted shoulder angle (PSA). The predictive capacity of CCFT for CNNP was evaluated using the ROC curve and area under the curve (AUC). Univariate and multivariate ordered logistic regression models were employed to analyze factors influencing CCFT scores.</p><p><strong>Results: </strong>The final analysis included 70 participants in the CNNP group and 123 in the control group. The CNNP group demonstrated lower CCFT scores, reduced maximal muscle strength, and decreased endurance of the deep cervical muscles (<i>P</i><0.05). Among maximum muscle strength, endurance, and CCFT scores, the latter exhibited the highest AUC. Univariate and multivariate ordered logistic regression analyses revealed that maximal muscle strength, muscle endurance, FHA, and lower NDI scores significantly increased the likelihood of higher CCFT scores (<i>P</i><0.05), while SHA significantly decreased this likelihood <i>(P</i><0.05).</p><p><strong>Conclusion: </strong>CCFT demonstrates good predictive value for CNNP, surpassing muscle strength and endurance. Maximal muscle strength, muscle endurance, FHA, and lower NDI scores were positive influencing factors for CCFT scores, whereas SHA was a negatively influencing factor.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3817-3828"},"PeriodicalIF":2.5,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathophysiology of Pain and Mechanisms of Neuromodulation: A Narrative Review (A Neuron Project).","authors":"Marcin Karcz, Alaa Abd-Elsayed, Krishnan Chakravarthy, Mansoor M Aman, Natalie Strand, Mark N Malinowski, Usman Latif, David Dickerson, Tolga Suvar, Timothy Lubenow, Evan Peskin, Ryan D'Souza, Eric Cornidez, Andrew Dudas, Christopher Lam, Michael Farrell Ii, Geum Yeon Sim, Mohamad Sebai, Rosa Garcia, Lucas Bracero, Yussr Ibrahim, Syed Jafar Mahmood, Marco Lawandy, Daniel Jimenez, Leili Shahgholi, Kamil Sochacki, Mohamed Ehab Ramadan, Vinicius Tieppo Francio, Dawood Sayed, Timothy Deer","doi":"10.2147/JPR.S475351","DOIUrl":"10.2147/JPR.S475351","url":null,"abstract":"<p><p>Pain serves as a vital innate defense mechanism that can significantly impact an individual's quality of life. Understanding the physiological effects of pain well plays an important role in developing novel pain treatments. Nociceptor neurons play a key role in pain and inflammation. Interactions between nociceptors and the immune system occur both at the site of injury and within the central nervous system. Modulating chemical mediators and nociceptor activity offers promising new approaches to pain management. Essentially, the sensory nervous system is essential for modulating the body's protective response, making it critical to understand these interactions to discover new pain treatment strategies. New innovations in neuromodulation have led to alternatives to opioids individuals with chronic pain with consequent improvement in disease-based treatment and nerve targeting. New neural targets from cellular and structural perspectives have revolutionized the field of neuromodulation. This narrative review aims to elucidate the mechanisms of pain transmission and processing, examine the characteristics and properties of nociceptors, and explore how the immune system influences pain perception. It further provides an updated overview of the physiology of pain and neuromodulatory mechanisms essential for managing acute and chronic pain. We assess the current understanding of different pain types, focusing on key molecules involved in each type and their physiological effects. Additionally, we compare painful and painless neuropathies and discuss the neuroimmune interactions involved in pain manifestation.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3757-3790"},"PeriodicalIF":2.5,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11581984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophil-to-Lymphocyte Ratio and Eosinophil Count as New Predictive Markers for Osteoarthritis.","authors":"Jingkai Di, Liying Song, Yaru Liu, Zhibo Zhang, Yawen Wu, Tingting Chen, Chuan Xiang","doi":"10.2147/JPR.S480925","DOIUrl":"10.2147/JPR.S480925","url":null,"abstract":"<p><strong>Purpose: </strong>Despite the association between peripheral blood inflammatory biomarkers and a range of inflammatory diseases, the role of these biomarkers in osteoarthritis (OA) progression remains unclear. Additionally, whether alterations in these inflammatory markers impact the prognosis of OA patients remains an understudied area. The aim of our study was to investigate the specific associations between peripheral blood inflammatory markers and OA progression and OA-related mortality.</p><p><strong>Methods: </strong>Data were obtained from the National Health and Nutrition Examination Survey (NHANES) database from 1999 through 2018. The primary outcomes were all-cause mortality, cardiac mortality, and renal disease mortality, with information on the corresponding mortality rates for each participant obtained through association with the National Death Index (NDI). Multivariate logistic regression models were used to examine the relationship between peripheral blood lymphocyte counts and OA, and restricted cubic spline (RCS) analysis was utilized to assess whether there was a nonlinear relationship with OA and mortality of OA patients. Interaction and stratified analyses were employed to explore the association between peripheral blood leukocyte counts and OA.</p><p><strong>Results: </strong>This study included 1077 OA patients and 21,612 non-OA participants. In model 3 fully adjusted for covariates, eosinophil-to-lymphocyte ratio (ELR) and eosinophil (EOS) were positive risk factors promoting the development of OA (OR = 3.26, 95% CI: 1.49-7.14; OR = 1.79, 95% CI: 1.12-2.88). In stratified models for age, sex, BMI, smoking status, and alcohol consumption, the associations of ELR and EOS with OA were significantly different. RCS curves showed a J-shaped relationship between ELR and EOS and all-cause mortality in patients with OA. ELR was also found to significantly up-regulate cardiac mortality and renal mortality in patients with OA (OR = 3.92, 95% CI: 1.68-9.14; OR = 22.55, 95% CI: 6.55-77.70), while EOS was only significantly positively correlation (OR = 3.68, 95% CI: 1.94-7.01).</p><p><strong>Conclusion: </strong>A significant relationship was found between ELR, EOS and OA. In addition, ELR and EOS were identified as potential predictors of mortality from different causes in patients with OA.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3803-3815"},"PeriodicalIF":2.5,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Causal Relationship Between Immune Cells and Temporomandibular Related Pain by Bi‑Directional Mendelian Randomization Analysis.","authors":"Jianquan He, Xiayun Chen","doi":"10.2147/JPR.S486817","DOIUrl":"10.2147/JPR.S486817","url":null,"abstract":"<p><strong>Introduction: </strong>Even with significant progress has been made in elucidating the pathogenesis of temporomandibular disorders (TMD), the pathophysiology of temporomandibular joint (TMJ) pain is still obscure. Our study aimed to explore whether there is a causal link between immune cells and TMD-related pain.</p><p><strong>Materials and methods: </strong>Based on the TMD-related pain data obtained from the FinnGen Research Consortium and the 731 immune traits extracted from the GWAS Catalog and utilized a two sample Mendelian Randomization (MR) method, with immune cell as the exposure and TMD-related pain as the outcome. MR analyses were conducted employing the inverse-variance weighting method (IVW) as the primary analytical method to evaluate the causal association. Sensitivity analyses were conducted to enhance the robustness, heterogeneity and horizontal pleiotropy of the results. A reverse MR analysis was also conducted for immune cell traits identified in the initial MR analysis.</p><p><strong>Results: </strong>After false discovery rate (FDR) correction, two immune traits were observed and found to be significantly associated with TMD-related pain: Hematopoietic Stem Cell absolute count (OR=0.954, 95% CI= 0.933~0.976), and HLA DR+ CD4+ T cell (OR=1.040, 95% CI=1.019~1.061). On the reverse MR analysis, no significantly associated results were found in causal effects of TMD-related pain on immune traits.</p><p><strong>Conclusion: </strong>Our study showed a potential causal relationship between immune cells and TMD-related pain, eliminating reverse causality. These discoveries significantly enhance our knowledge of the interaction between immune traits and TMD-related pain, opening new possibilities for designing treatment from an immunological perspective.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3791-3800"},"PeriodicalIF":2.5,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Commentary on \"Chitosan, a Natural Polymer, is an Excellent Sustained-Release Carrier for Amide Local Anesthetics\" [Letter].","authors":"Yanlin Wu, Junhao Fang, Ying Jian","doi":"10.2147/JPR.S504807","DOIUrl":"10.2147/JPR.S504807","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3801-3802"},"PeriodicalIF":2.5,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Intravenous Lidocaine Compared with Quadratus Lumborum Block on Postoperative Analgesia Following Laparoscopic Renal Surgery: Protocol for a Randomized Noninferiority Trial\" [Letter].","authors":"Xuefan Zeng, Yiwei Wang","doi":"10.2147/JPR.S504993","DOIUrl":"10.2147/JPR.S504993","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3755-3756"},"PeriodicalIF":2.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation, Cultural Adaptation and Validation of the Medication Adherence Report Scale (MARS-5) in Nepalese Cancer Patients Experiencing Pain.","authors":"Sunil Shrestha, Simit Sapkota, Vibhu Paudyal, Zoe Moon, Rob Horne, Siew Hua Gan","doi":"10.2147/JPR.S455852","DOIUrl":"10.2147/JPR.S455852","url":null,"abstract":"<p><strong>Background: </strong>Adherence to pain medication is crucial for cancer patients, since non-adherence can lead to increased suffering, reduced quality of life and increased healthcare costs. Although the five-item Medication Adherence Report Scale (MARS-5) is a validated tool for assessing medication adherence, but it has not been translated and validated into the Nepalese language. This study aimed to translate, culturally adapt and validate the MARS-5 in Nepalese language for Nepalese cancer patients who were experiencing pain.</p><p><strong>Materials and methods: </strong>The cross-sectional validation study utilized a convenience sampling method. Initially, a pre-test was conducted with 25 patients. The MARS-5 was then forward and backward translated following the EORTC QLG translation procedure. The final translated version was reviewed by experts and subjected to a second pre-test. Construct validity was assessed through principal component analysis, and internal consistency was measured using Cronbach's alpha coefficient. Inter-rater reliability was evaluated using the Intra-Class Correlation coefficient (ICC).</p><p><strong>Results: </strong>The study included 204 cancer patients (ages 18-86, 55% female). The Nepalese version of the MARS-5 was translated without significant issues and underwent pre-testing with participants. Participants discussed the scale during these pre-tests, providing feedback on its clarity and comprehensibility. While formal assessment tools were not employed, the iterative nature of the pre-testing process allowed for the refinement of the translation based on participant feedback, indicating a robust understanding of the scale among participants. The ICC of test-retest reliability was found to be 0.860. The Kaiser Meyer Olkin's value was 0.690, and Cronbach's alpha was 0.72, indicating good construct validity and high internal consistency. The medication non-adherence rate was 11.3%.</p><p><strong>Conclusion: </strong>The MARS-5 was successfully translated, culturally adapted, and validated in Nepalese for use among Nepalese cancer patients experiencing pain. The Nepalese version of MARS-5 is a reliable tool for evaluating medication adherence in this population.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3741-3753"},"PeriodicalIF":2.5,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous Adductor Canal Block Compared to Epidural Anesthesia for Total Knee Arthroplasty.","authors":"Isaac G Freedman, Michael R Mercier, Anoop R Galivanche, Mani Ratnesh S Sandhu, Mark Hocevar, Harold Gregory Moore, Jonathan N Grauer, Lee E Rubin, Jinlei Li","doi":"10.2147/JPR.S462079","DOIUrl":"10.2147/JPR.S462079","url":null,"abstract":"<p><strong>Aim: </strong>To compare the efficacy of a postoperative continuous adductor canal block (cACB) with and without a steroid adjuvant to that of epidural analgesia (EA).</p><p><strong>Methods: </strong>Patients who underwent primary total TKA at a single institution between July 2011-November 2017 were included for retrospective analysis. TKA patients were stratified into one of the three analgesia approaches: EA, cACB without steroid adjuvant, and cACB with steroid adjuvant. Hospital length of stay (LOS), discharge disposition, incidence of postoperative adverse events, and total milligram morphine equivalents (MME) requirements were compared between strata. Logistic regressions were performed to assess the independent effect of analgesia approach on prolonged LOS greater than 3 days (pLOS), non-home discharge, and total and daily MME requirements (tMME and dMME) following TKA.</p><p><strong>Results: </strong>Of the 4345 patients undergoing TKA, 1556 (35.83%) received EA, 2087 (48.03%) received cACB without steroids, and 702 (16.13%) cACB with steroids. cACB patients experienced lower rates of pLOS, higher rates of discharge to home than EA patients, and lower tMME and dMME. On multivariable analysis, cACB groups were at a lower odds of experiencing a pLOS compared to EA patients without steroids (OR = 0.64; 95% CI 0.49-0.84; with steroids: OR = 0.54; 95% CI 0.38-0.76). cACB groups had lower odds of a non-home discharge when compared to EA patients (without steroids OR = 0.42; 95% CI 0.36-0.48; with steroids: OR 0.22; 95% CI 0.18-0.27). On multivariable analysis, cACB groups required less tMME compared to the EA group (without steroids β=-290 mmE; 95% CI: -313 to -268 mmE; with steroids: β=-261 mmE; 95% CI: -289 to -233 mmE) as well as lower dMME (without steroids: β=-66 mmE/day; 95% CI -72 to -60 mmE/day; with steroids: β=-48 mmE/day; 95% CI -55 to -40 mmE/day).</p><p><strong>Conclusion: </strong>cACB was associated with greater discharge to home rates, lower rates of pLOS, and lower tMME and dMME consumption.</p><p><strong>Level of evidence: </strong>Level III.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3729-3740"},"PeriodicalIF":2.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative Pain Observation of Hip Fracture Surgery Patients with Cheek Acupuncture.","authors":"Xingmei Xu, Libin Zhao, Yue Li, Li Zhan, Lidong Zheng, Jingxian Wang","doi":"10.2147/JPR.S491669","DOIUrl":"10.2147/JPR.S491669","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study is to investigate the impact of cheek acupuncture on perioperative pain in patients with hip fracture.</p><p><strong>Methods: </strong>A random number table was utilized to allocate the patients into three distinct cohorts: Only spinal anesthesia was performed (group S), cheek acupuncture was performed before spinal anesthesia (group C), and ultrasound-guided fascia iliaca block was performed before spinal anesthesia (group F). The primary outcome measure was the Visual Analogue Scale (VAS) score within 24 hours post-surgery, as well as the level of beta-endorphin. The secondary outcome measures included intraoperative mean arterial pressure (MAP), heart rate (HR), length of hospital stay, postoperative complications, levels of interleukin-6 (IL-6), and degree of motor block.</p><p><strong>Results: </strong>Compared to Group S, patients in group C and group F exhibited significantly lower Visual Analog Scale (VAS) scores at the following endpoints: when the patient is positioned in the spinal anesthesia position (T₂); 12 hours post-surgery (T₅); and 24 hours post-surgery (T₆). And patients in group C and group F demonstrated a decreased beta-endorphin level at the T₆. Compared to Group S, patients in group C and group F displayed reduced Mean Arterial Pressure (MAP) levels at T₂.</p><p><strong>Conclusion: </strong>The application of cheek acupuncture therapy in hip fracture surgery can effectively reduce the Visual Analog Scale (VAS) score, enhance perioperative safety, facilitate postoperative recovery, and optimize the overall medical experience for patients.</p><p><strong>Clinical trial: </strong>ChiCTR2100043194.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3719-3727"},"PeriodicalIF":2.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Controlled Non-Inferiority Trial Evaluating Opioid-Free versus Opioid-Sparing Analgesia for Orbital Fracture Reconstruction Under General Anesthesia.","authors":"Rui Zhang, Yongjian Mai, Huijing Ye, Xiufen Lian, Huasheng Yang, Yanling Zhu, Xiaoliang Gan","doi":"10.2147/JPR.S491994","DOIUrl":"10.2147/JPR.S491994","url":null,"abstract":"<p><strong>Background and objectives: </strong>Opioid-minimizing strategies are making their appearance in enhanced recovery after surgery. This study is aimed to explore the potential advantages of opioid-free analgesia (OFA) compared to opioid-sparing analgesia (OSA) in patients undergoing orbital fracture reconstruction.</p><p><strong>Methods: </strong>In this prospective, single-center, randomized controlled study, we randomly recruited 122 patients undergoing orbital fracture reconstruction under general anesthesia. Patients received total intravenous anesthesia with a flexible laryngeal mask airway, and multimodal analgesia with either OSA or OFA methods. The OSA group (n = 61) received low doses of fentanyl and nonsteroidal anti-inflammatory drugs (NSAIDs), and the OFA group (n = 61) received medial canthus peribulbar block (MCPB) combined with NSAIDs. The primary outcomes consisted of area-under-the-curve (AUC) of the numerical rating scale (NRS) pain score, and the incidence of postoperative nausea and vomiting (PONV) through the first 24h.</p><p><strong>Results: </strong>Compared to the OSA group, the OFA group demonstrated non-inferiority in postoperative analgesia through the first 24 postoperative hours (difference of the medians, -6; 95% confidence interval [CI], -12 to 6), but failed to meet the non-inferiority criterion in the incidence of PONV (difference ratio, 3%; 95% CI, -7% to 14%). The Quality of Recovery-40 questionnaire (QoR-40) scores on postoperative day 1 was significantly higher in group OFA compared to group OSA (188 [178 to 196] vs 181 [169 to 191], respectively; <i>P</i> = 0.005).</p><p><strong>Conclusion: </strong>In orbital fracture reconstruction, both OFA and OSA strategies provide effective postoperative pain relief, but OFA using MCPB combined NSAIDs enhances the quality of early postoperative recovery.</p><p><strong>Registered: </strong>Chinese Clinical Trial Registry ChiCTR1900028088.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3707-3717"},"PeriodicalIF":2.5,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}