Journal of Pain Research最新文献

{"title":"Efficacy of Selective Nerve Root Block for Different Types of Lumbar Disc Herniation: Study Protocol for a Single-Blind, Prospective Cohort Study.","authors":"Hongping Tan, Jing Zhou, Yijin Pu, Lin He, Liu Wang","doi":"10.2147/JPR.S494496","DOIUrl":"10.2147/JPR.S494496","url":null,"abstract":"<p><strong>Background: </strong>Lumbar disc herniation (LDH) is a common cause of low back pain and radiculopathy. Selective Nerve Root Block (SNRB) has been widely used as a treatment for LDH; however, its efficacy across different types of LDH remains unclear. This study aims to evaluate the clinical efficacy of SNRB in treating various LDH subtypes, classified according to the Michigan State University (MSU) classification system, and to explore its potential as a safe and minimally invasive percutaneous treatment option.</p><p><strong>Methods: </strong>This is a single-blind, Prospective Cohort Study. A total of 200 patients diagnosed with LDH will be recruited and allocated into 10 groups (20 patients per group) based on their MSU classification (1-A, 1-B, 1-C, 2-AB, 2-A, 2-B, 2-C, 3-AB, 3-A, and 3-B). All patients will receive SNRB treatment under fluoroscopic guidance. Primary outcomes will include the Visual Analogue Scale (VAS) for pain intensity. Secondary outcomes will include the Oswestry Disability Index (ODI), health-related quality of life (Short Form-36, SF-36) and average weekly analgesic consumption. Assessments will be conducted at baseline, 1 day, 1 week, 2 weeks, 1 month, 3 months, 6 months, and 1 year post-treatment.</p><p><strong>Discussion: </strong>This study will provide high-quality evidence on the efficacy of SNRB in different LDH subtypes, classified according to the MSU system. The findings will guide clinical decision-making and promote the adoption of SNRB as a minimally invasive, safe, and effective treatment option for LDH.</p><p><strong>Trial registration: </strong>This clinical trial is registered on the Chinese Clinical Trial Registry platform (ChiCTR) at https://www.chictr.org.cn/index.html, identifier: ChiCTR2200067212.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1035-1043"},"PeriodicalIF":2.5,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interlaminar Endoscopic Treatment of Adjacent Segment Disease After Posterior Instrumented Lumbar Fusion.","authors":"Min Liang, Xinyang Shao, RenHan Zhu, Kun Li, Liangchen Shi, Yansong Wang","doi":"10.2147/JPR.S498800","DOIUrl":"10.2147/JPR.S498800","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the feasibility of interlaminar endoscopic surgery for the treatment of adjacent segment disease (ASD) after posterior instrumented lumbar fusion.</p><p><strong>Materials and methods: </strong>Between January 2019 and March 2023, the data of 22 patients with ASD who underwent revision interlaminar technique (R-ILT) endoscopic surgery after posterior instrumented lumbar fusion were retrospectively analyzed. For comparison, the data of 30 patients with single segment lumbar spinal stenosis who underwent primary interlaminar technique (P-ILT) endoscopic surgery were collected. The patient demographics and perioperative indicators were recorded and the clinical outcomes were analyzed with relevant evaluation scales. The surgical satisfaction was assessed using the modified MacNab criteria, lumbar stability was evaluated using the change in dynamic position radiographs of the spine at the final follow-up.</p><p><strong>Results: </strong>There were no statistical differences in patient demographics. The operation time, blood loss, fluoroscopy time, and the incidence of dural sac tears were higher in R-ILT group (<i>p</i> < 0.05). Both groups had significant relief in their lower back and leg pain symptoms, but the relief of the low back pain in R-ILT group was not as good as that in P-ILT group. Regarding recovery of lower limb function, the results of both groups were similar, according to the modified MacNab criteria, the good-to-excellent rate was 81.82% in R-ILT group and 86.66% in P-ILT group. The change in dynamic position X-ray of the spine proved that ILT would not destroy the stability of the spine.</p><p><strong>Conclusion: </strong>Interlaminar endoscopic surgery is a feasible option for treating ASD. However, due to the impact of the initial operation, the difficulty and risk of reoperation have increased; therefore, surgical indications must be strictly controlled, and superb surgical skills are required.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1011-1019"},"PeriodicalIF":2.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Non-Pharmacological Therapies for Primary Dysmenorrhea: A Network Meta-Analysis.","authors":"Jun Liu, Yu Wang, Juncha Zhang, Xisheng Fan, Hao Chen, Guang Zuo, Xuesong Wang, Yanfen She","doi":"10.2147/JPR.S498184","DOIUrl":"10.2147/JPR.S498184","url":null,"abstract":"<p><strong>Background: </strong>This network meta-analysis (NMA) aimed to explore the impact of Non-pharmacological therapies (NPT) on alleviating primary dysmenorrhea (PD) symptoms and assess the effectiveness differences among various NPT.</p><p><strong>Methods: </strong>We searched seven databases and summarized clinical trials of PD treated with NPT from inception to September 6, 2023. Randomized controlled clinical trials (RCTs) of PD treated with NPT. The outcomes were the Visual Analog Scale (VAS), the Cox menstrual symptom scale (CMSS), and response rate. Quality was assessed using the Cochrane risk of bias assessment tool. Pairwise meta-analysis and network meta-analysis (NMA) was performed by RevMan (5.4), Stata (15.0), and WinBUGS (1.4.3). The ranking probabilities for all treatment interventions were performed using the Surface Under the Cumulative Ranking curve (SUCRA).</p><p><strong>Results: </strong>A total of 16 RCTs were finally included, involving 8 kinds of NPT. Results of pairwise meta-analyses: For the VAS score results, moxibustion (SMD: -0.591,95% CI: -0.916, -0.266) was more effective than acupuncture, acupuncture (SMD: -0.948,95% CI: -1.853, -0.044) was more effective than placebo, and yoga (SMD: 2.634,95% CI: -4.28, -0.988) was more effective than the blank control. NMA results: Compared to the blank control, acupuncture (SMD: -4.81; 95% CI: -6.63, -3.00), auricular point therapy (SMD: -4.36; 95% CI: -7.18, -1.60), yoga (SMD: -2.12; 95% CI: -3.13, -1.09), moxibustion (SMD:5.54; 95% CI: 3.33, 7.68), and placebo (SMD: 3.10; 95% CI: 1.03, 5.27) proved to be a superior reduction in VAS. The use of acupressure (SMD: 2.49; 95% CI: 0.03, 5.03), moxibustion (SMD: -2.45; 95% CI: -4.06, -0.71), and acupuncture (SMD: -1.72; 95% CI: -2.75, -0.56) demonstrated a greater decrease in VAS efficacy than placebo. The consolidated ranking outcomes indicate that moxibustion, acupuncture, and auricular acupoint therapy occupy high SUCRA positions across various outcome metrics.</p><p><strong>Conclusion: </strong>Acupuncture, moxibustion and auricular point may be the best treatment for PD. In the future, more trials are needed to obtain higher-quality evidence and the best protocols.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"975-991"},"PeriodicalIF":2.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on Pain Management Strategies After Hepatectomy, a Narrative Review of Therapeutic Options [Response to Letter].","authors":"Yuqin Wang, Xiuxiu Song","doi":"10.2147/JPR.S520193","DOIUrl":"https://doi.org/10.2147/JPR.S520193","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"961-962"},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethink of the New Treatment for Refractory Painful Diabetic Peripheral Neuropathy [Response to Letter].","authors":"Weisheng Xu, Jiying Wang, Fuqing Lin","doi":"10.2147/JPR.S521253","DOIUrl":"https://doi.org/10.2147/JPR.S521253","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"959-960"},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the Progression of Pain Pathways and Identifying Chronification of Pain Predictors After an Isolated Lateral Ankle Sprain: Project RECOIL.","authors":"Kyle B Kosik, Matthew C Hoch, Ilana Patlan, Stacey Slone, Danielle M Torp, Joshua J Van Wyngaarden, Megan H Roach","doi":"10.2147/JPR.S488420","DOIUrl":"10.2147/JPR.S488420","url":null,"abstract":"<p><p>Persistent pain is a common complaint among civilians and military personnel after a lateral ankle sprain (LAS). Most individuals who experience pain after an LAS self-report a moderate pain intensity level that interferes with activity. This pain experience is mostly described through study designs and outcomes that limit the understanding of the acute to chronic pain transition after an LAS. The purpose of this prospective study is to quantify the prevalence rate of chronic ankle pain at 6-months post-injury and identify susceptibility and resiliency factors that contribute to pain chronification after an LAS. The objective of this study will be accomplished through a two-site prospective cohort study design with data collected at four timepoints (<7 days post-LAS, 3-, 6-, and 12-months post-LAS). A target sample size of 200 men or women (100 per site) between 18 and 45 years of age who sustain an acute LAS within the previous 7-days will be enrolled. Participants will complete a series of standardized electronic surveys at each timepoint to self-report the presence of chronic ankle pain, healthcare utilization patterns, subsequent musculoskeletal injury, and new co-morbid conditions. Additionally, participants will complete validated patient-reported outcomes (PROs) electronically to characterize the pain burden and undergo quantitative sensory testing to assess mechanical pain sensitivity via pressure pain thresholds, pain facilitation via temporal summation, and pain inhibition via a conditioned pain modulation response at all timepoints. Lastly, clinician-based outcomes will be completed at 3-, 6-, and 12-months post-LAS to examine dynamic postural control, functional performance, and walking mechanics. We hypothesize that 30% of participants will self-report chronic ankle pain at 6-months post-injury. In addition, chronic pain at 6-months will be predicted by a combination of healthcare utilization patterns, prolonged levels of peripheral sensitization and pain facilitation, and worse functional performance and PROs.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"931-945"},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Prophylactic Intrathecal or Epidural Normal Saline for Preventing Post-Dural Puncture Headache After Dural Puncture: A Meta-Analysis and Systematic Review.","authors":"Weiwei Jing, Yushan Ma, Yantong Wan, Hao Li","doi":"10.2147/JPR.S494237","DOIUrl":"https://doi.org/10.2147/JPR.S494237","url":null,"abstract":"<p><strong>Background: </strong>Post-dural puncture headache (PDPH) is the most common and troublesome complication following iatrogenic puncture of the dura. This study aims to evaluate the efficacy and safety of intrathecal or epidural saline injection to prevent PDPH.</p><p><strong>Methods: </strong>A systematic literature search was conducted in PubMed, Embase, Web of Science, and the Cochrane Library, supplemented by a manual search of reference lists of related articles. Studies were eligible if they compared intrathecal or epidural injection or continuous saline infusion with no intervention in patients with accidental or intentional dural puncture. Trials reporting PDPH outcomes were considered eligible. The type of surgeries and patient populations were not restricted. Risk ratios (RRs) with 95% confidence intervals (CI) were calculated for the risk estimate of dichotomous outcomes. The funnel plot, Egger, and Begg tests were performed to assess the publication bias.</p><p><strong>Results: </strong>We identified 13 studies involving 1589 patients, revealing a high publication bias. Normal saline injection reduced the incidence of PDPH (RR=0.57, 95% CI: 0.43 to 0.74, P<0.0001, I²=66%, P-heterogeneity=0.0004) and the requirement for an epidural blood patch (RR=0.37, 95% CI: 0.25 to 0.54, P<0.00001, I²=29%, P-heterogeneity=0.23).</p><p><strong>Conclusion: </strong>Saline administration after dural puncture appears to be a promising option for preventing PDPH. However, heterogeneity among the studies and publication bias with positive results limits the available evidence. Therefore, further large-scale randomized controlled trials are needed to confirm our findings.</p><p><strong>Register: </strong>CRD42022342509.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"915-927"},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Thai Version of the Chronic Pain Acceptance Questionnaire-8 (CPAQ-8T) in Chronic Pain Patients.","authors":"Koravee Pasutharnchat, Rattaphol Seangrung, Prateep Lertmongkonaksorn, Sirima Kamdeang","doi":"10.2147/JPR.S500597","DOIUrl":"10.2147/JPR.S500597","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic pain significantly affects patients' quality of life, leading to the avoidance of activities that exacerbate their pain. Embracing pain acceptance and willingness is crucial to maintain patients' functionality. This study aimed to translate and validate the Chronic Pain Acceptance Questionnaire-8 (CPAQ-8) into the Thai language and to facilitate the assessment of pain acceptance in Thai patients.</p><p><strong>Patients and methods: </strong>The study involved the translation of the English CPAQ-8 into a Thai version, subsequently, referred to as the CPAQ-8T. The psychometric properties of the CPAQ-8T were examined. Study participants were administered a set of questionnaires, including the 100-mm Visual Analog Scale (VAS), CPAQ-8T, and the Barthel Index for Activities of Daily Living (ADL). Test-retest reliability was assessed by readministering the CPAQ-8T two weeks after the initial test. The validity and overall reliability of the CPAQ-8T were thoroughly assessed.</p><p><strong>Results: </strong>A total of 160 patients with chronic pain at pain clinic, Ramathibodi Hospital completed all the questionnaires. The mean CPAQ-8T score was 24.2 (SD = 7.26). The CPAQ-8T score exhibited the expected correlation with the Barthel Index for ADL but showed no significant correlation with the VAS score, indicating moderate convergent validity. The internal consistency and test-retest reliability findings support the validity and reliability of the CPAQ-8T.</p><p><strong>Conclusion: </strong>The translation and validation of the CPAQ-8 into the Thai language offers a reliable and valid instrument for assessing pain acceptance in Thai patients with chronic pain. The results suggested that the CPAQ-8T is a valuable tool for healthcare professionals and researchers working in the field of chronic pain management.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"947-957"},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873014/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and Experimental Verification of Potential Immune Cell-Associated Gene Biomarkers in Human Intervertebral Disc Degeneration.","authors":"Wei-Han Shi, Hui-Shuang Zou, Xiang-Yu Wang, Jie Lu, Hua-Qi Yu, Ping-Ping Zhang, Li-Li Huang, Peng-Cheng Chu, Da-Chuan Liang, Ya-Ning Zhang, Bin Li","doi":"10.2147/JPR.S505859","DOIUrl":"10.2147/JPR.S505859","url":null,"abstract":"<p><strong>Objective: </strong>Intervertebral disc degeneration (IDD) is one of the most common diseases in the elderly population. Recently, immune disorders have been considered to play an important role in IDD. This study aimed to conduct a bioinformatic analysis to identify biomarkers associated with IDD immune cells.</p><p><strong>Methods: </strong>We obtained the gene expression profiles of IDD by downloading the Gene Expression Omnibus Series (GSE)150408 and GSE124272 from the Gene Expression Omnibus (GEO) database. IDD and immune cell-related hub genes were identified via multiple bioinformatics analyses, and their diagnostic performance was evaluated using receiver operating characteristic (ROC) analysis. In addition, a long non-coding RNA (lncRNA)-signature gene co-expression network was constructed. Finally, the diagnostic accuracy of the biomarkers was verified using Real-time quantitative PCR (RT-qPCR).</p><p><strong>Results: </strong>ASAP1-IT1, IKZF2, KLHL14, lnc-C10orf131-1, and LOC101927805 were identified as signature genes of IDD. Further, ROC analysis revealed that the five signature gene models had a strong ability to discriminate between the IDD and healthy control samples. We also found that the five signature genes were significantly associated with immune-inflammatory feedback, cell cycle, and skeletal system. Furthermore, an lncRNA signature gene network was constructed to reveal the regulatory mechanisms of the biomarkers. Finally, RT-qPCR results verified that IKZF2 and KLHL14 were significantly downregulated in patients with IDD, and ASAP1-IT1 was significantly upregulated.</p><p><strong>Conclusion: </strong>This study identified ASAP1-IT1, IKZF2, and KLHL14 as the key signature genes of IDD. These key hub genes may serve as potential therapeutic targets for IDD.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"993-1007"},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analgesic Quality Improvement in Paravertebral Blocks for Pediatric Nuss Procedure: An Exploratory Report on the Effects of Perineural Combined Glucocorticoids [Response to Letter].","authors":"XueWei Zhang, Evan Jin, Jinlei Li","doi":"10.2147/JPR.S523930","DOIUrl":"https://doi.org/10.2147/JPR.S523930","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1009-1010"},"PeriodicalIF":2.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}