Journal of Pain Research最新文献

{"title":"Addressing Limitations and Future Directions in the Use of Glucocorticoids for Pediatric Nuss Procedure Analgesia: A Critical Appraisal [Letter].","authors":"Zi-Heng Li","doi":"10.2147/JPR.S522919","DOIUrl":"10.2147/JPR.S522919","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"815-816"},"PeriodicalIF":2.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical Role of p38α MAPK Subclass in the Development of Pain Hypersensitivity After Hind Paw Incision.","authors":"Daiki Ishikawa, Shunsuke Yamakita, Kentaro Oh-Hashi, Fumimasa Amaya","doi":"10.2147/JPR.S488494","DOIUrl":"10.2147/JPR.S488494","url":null,"abstract":"<p><strong>Background: </strong>Deeper understanding of the mechanisms of postoperative pain is critical for developing more effective pain management strategies. The present animal study explored the function of four p38 mitogen-activated protein kinase (MAPK) subclasses (α, β, γ, and δ) in dorsal root ganglion (DRG) in the development of post-incisional pain hypersensitivity.</p><p><strong>Methods: </strong>The amount of p38 MAPK subclass mRNA in the DRG of male Sprague-Dawley rats was quantified using real-time PCR. Localization of p38 MAPK expression was analyzed by immunohistochemistry using subclass-selective antibodies. The effects of a p38α MAPK inhibitor on plantar incision-induced pain hypersensitivity was assessed using behavioral tests to measure mechanical and thermal sensitivity. The impact of the inhibitor on phosphorylated p38 MAPK expression was also analyzed by immunohistochemistry.</p><p><strong>Results: </strong>Four p38 MAPK subclass mRNA were identified in the DRG, with p38α, β, and γ MAPK showing significant expression. p38α and γ MAPK were identified in the DRG neurons, whereas p38β MAPK was distributed in satellite glial cells. Selective inhibition of p38α MAPK reduced both mechanical and thermal hypersensitivity following plantar incision. Treatment with the p38α MAPK inhibitor decreased the expression of phosphorylated p38 MAPK in the DRG.</p><p><strong>Conclusion: </strong>These results demonstrated the distinct roles of p38 MAPK subclasses in the DRG, with p38α MAPK playing a dominant role in the development of pain hypersensitivity after tissue injury. Targeting p38α MAPK might be a promising therapeutic strategy for managing postoperative pain.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"869-878"},"PeriodicalIF":2.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain Intensity in Patients with Opioid Use Disorder on Extended-Release Naltrexone or Opioid Agonists; The Role of COMT rs4680 and OPRM1 rs1799971: An Exploratory Study.","authors":"Farid Juya, Ann Christin Sannes, Kristin Klemmetsby Solli, Bente Weimand, Johannes Gjestad, Lars Tanum, Jon Mordal","doi":"10.2147/JPR.S500984","DOIUrl":"10.2147/JPR.S500984","url":null,"abstract":"<p><strong>Purpose: </strong>To examine whether reported pain intensity over time is related to the single nucleotide polymorphisms of the catechol-O-methyltransferase (COMT rs4680) and mu-opioid receptor (OPRM1 rs1799971) in patients with opioid use disorder (OUD) choosing treatment with extended-release naltrexone (XR-NTX) or opioid agonist treatment (OAT).</p><p><strong>Patients and methods: </strong>This exploratory study was part of a 24-week, open-label clinical prospective trial of patients with OUD who chose intramuscular XR-NTX, and patients receiving OAT. Men and women aged 18 to 65 years with OUD per the Diagnostic and Statistical Manual of Mental Disorders, fifth edition were included. Pain intensity was measured at baseline and at 24-week follow-up using the Numerical Pain Rating Scale-11 and genotyping was performed by TaqMan technology. Data were analyzed with ordinal logistic regression.</p><p><strong>Results: </strong>Of 317 participants included at baseline, 210 samples were obtained and analyzed. In the OAT group, there was a negative significant association between pain intensity and having the Val/Val allele of COMT rs4680 (wild-type = most common type) and the rare allele G of OPRM1 rs1799971 at 24-week follow-up. No such effects were seen in the XR-NTX group.</p><p><strong>Conclusion: </strong>The wild-type allele Val/Val of COMT rs4680 and the rare allele G of OPRM1 rs1799971 may have a possible protective effect regarding pain intensity in patients with OUD receiving OAT. Given relatively low sample size, particularly low number of female participants in the XR-NTX group and other possible confounders, our findings should be interpreted with caution.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"827-836"},"PeriodicalIF":2.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Analysis of the Minimum Clinically Important Difference in the Brief Pain Inventory After Total Knee Arthroplasty.","authors":"Shunxing Wang, Shuxin Yao, Peng Xiao, Lei Shang, Chao Xu, Jianbing Ma","doi":"10.2147/JPR.S501219","DOIUrl":"10.2147/JPR.S501219","url":null,"abstract":"<p><strong>Purpose: </strong>Research on the Minimum Clinically Important Difference (MCID) of the Brief Pain Inventory (BPI) following Total Knee Arthroplasty (TKA) is limited. This study addresses this gap by determining the MCID of the BPI for patients undergoing primary TKA.</p><p><strong>Patients and methods: </strong>This study was designed to quantitatively determine the MCID of the BPI for patients undergoing primary TKA. A prospective cohort of 288 patients was evaluated, with the BPI administered both preoperatively and at a one-year follow-up. The MCID was calculated using two primary approaches: the anchor-based method, considered the gold standard, and the distribution-based method. Additionally, this study explored various calculation approaches within the distribution-based framework, benchmarking them against the anchor-based method. The distribution-based methods included calculations based on Standard Deviation (SD), Effect Size (ES), Standardized Response Mean (SRM), and Standard Error of Measurement (SEM). All statistical calculations were performed using established formulas.</p><p><strong>Results: </strong>The anchor-based method determined the MCID for BPI pain severity to be 3.9 points, the pain interference dimension to be 5.8 points, and the total score to be 9.7 points. Comparisons with the gold standard highlighted the 0.65ES, 1.96SEM, and 0.5SRM methods as the most suitable approaches for distribution-based MCID estimation.</p><p><strong>Conclusion: </strong>The MCID for BPI in TKA patients was established using both anchor-based and distribution-based methods. When anchor-based determination is impractical, the distribution-based methods-0.65ES, 1.96SEM, and 0.5SRM-are recommended for MCID calculation.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"803-813"},"PeriodicalIF":2.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which Kind of Prognosis is Better in the Treatment of Cervical and Lumbar Disc Herniation with Coblation Nucleoplasty?","authors":"Rongyi Zhang, Shi Chen, Liuhu Han, Bingbing Xu, Yuyu Guo, Likui Wang","doi":"10.2147/JPR.S500287","DOIUrl":"10.2147/JPR.S500287","url":null,"abstract":"<p><strong>Introduction: </strong>Coblation nucleoplasty is a minimally invasive procedure developed for the treatment of symptomatic disc herniation.</p><p><strong>Methods: </strong>We evaluated 118 cases of cervical and lumbar intervertebral discs treated with coblation nucleoplasty. The clinical results were assessed using the visual analogue scale (VAS), modified MacNab criteria, and efficacy. Complications and the re-surgery rate were also evaluated. The procedure was carried out under CT guidance, and the patients were followed up for 1 day, 1 month, 6 months, and 5 years postoperative.</p><p><strong>Results: </strong>At the 5-year follow-up, the VAS score in the cervical and lumbar groups significantly decreased from 6.20 to 2.43 and 6.11 to 3.29, respectively. While MacNab scores were indistinguishable at the 6-month follow-up, they differed significantly between the cervical (58.2%) and lumbar (34.9%) groups at the 5-year follow-up. At the 5-year follow-up, 6 patients in the cervical group and 11 in the lumbar group underwent conventional operation. The efficacy of coblation nucleoplasty at the 5-year follow-up was higher in cervical group (81.82%) compared with lumbar group (61.90%).</p><p><strong>Conclusion: </strong>The results of this study suggest that coblation nucleoplasty is a safe and effective treatment option for patients with cervical and lumbar disc herniation. The long-term benefits of this procedure were more pronounced in patients with cervical disc herniation.</p><p><strong>Clinical trial registration: </strong>The trial was registered on ClinicalTrials.gov (ChiCTR2400089145).</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"817-826"},"PeriodicalIF":2.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143492391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Commentary on \"The Association Between Specific Oral Behaviors and the Number of Temporomandibular Disorder Symptoms in the General Population: A Cross-Sectional Study\" [Response to Letter].","authors":"Yanyue Tan, Yihong Tian, Ming Yang, Xiayang Lv, Xin Xiong","doi":"10.2147/JPR.S519992","DOIUrl":"10.2147/JPR.S519992","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"783-784"},"PeriodicalIF":2.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Berberine Enhances Neuroregeneration in a Rat Model of Peroneal Nerve Transection Injury: An Animal Study.","authors":"Hyun-Ju Chung, Dong-Jin Kim, Yeon-Seo Kim, Sang-Ho Lee, Kang-Il Kim, Jae-Hoon Lee, Myung-Seo Kim","doi":"10.2147/JPR.S483968","DOIUrl":"10.2147/JPR.S483968","url":null,"abstract":"<p><strong>Background: </strong>Berberine has therapeutic potential in central nervous system disorders, however, few studies have investigated the effect of berberine on axonal regeneration in PNS injury models. Thus, this study aims to assess the effects of berberine on axonal regeneration in a peroneal nerve transection rat model.</p><p><strong>Methods: </strong>Sprague-Dawley rats were divided into two groups: group B, berberine (20 mg/kg) intraperitoneal injection after peroneal nerve transection; and group C, normal saline injection as a control. The sciatic nerve functional index (SNFI) was used to assess functional recovery after nerve injury at 2, 4, and 6 weeks post-transection. Electromyography (EMG) was performed to evaluate quantitative neuromuscular function (latency and amplitude) and the regeneration ratio of the injured nerve was evaluated through histological analysis at 6 weeks post-transection. To analyze the effect of various concentrations of berberine on nerve regeneration, Schwann cell viability was analyzed at 0, 0.1, 0.5, 1.0, 5.0 and 10.0 μM of berberine.</p><p><strong>Results: </strong>At 2 and 4 weeks post-transection, SNFI showed no significant difference between groups B and C. However, at 6 weeks post-transection, the SNFI was significantly higher in group B than in group C. On EMG, the latency and amplitude was significantly lower and higher, respectively, in group B than in group C. Histological analysis showed that the regeneration ratio was significantly higher in group B than in group C. Schwann cell viability was highest when 1.0 μM of berberine was administered (136.7±3.5%), and was significantly higher compared to the groups administered with 0.1 μM (114.5±10.6%) and 0.5 μM (118.5±4.8%).</p><p><strong>Conclusion: </strong>Berberine injections have a therapeutic effect on nerve regeneration after peripheral nerve transection. In in vitro studies, a minimum dose of 1.0 μM berberine was required to obtain optimal nerve regeneration. Further in vivo studies are needed to analyze the optimal concentration.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"749-758"},"PeriodicalIF":2.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Initial Validation of Mindfulness-Based Pain Reduction (MBPR) in Patients With Chronic Low Back Pain.","authors":"Wolf E Mehling, Carrie E Brintz, Wendy Hartogensis, Christiane Wolf, Kirsten Rogers, Shelley R Adler, Irina A Strigo, Frederick M Hecht","doi":"10.2147/JPR.S507003","DOIUrl":"10.2147/JPR.S507003","url":null,"abstract":"<p><strong>Purpose: </strong>Mindfulness-Based Stress Reduction (MBSR) has shown efficacy for alleviating chronic low back pain (cLBP) and is included in current treatment guidelines. However, benefits are moderate. We aimed to optimize MBSR for chronic pain by using recent research to develop Mindfulness-Based Pain Reduction (MBPR) and test it in patients with cLBP.</p><p><strong>Patients and methods: </strong>Phase 1: We modified the MBSR curriculum with theory-driven components and convened focus groups with local and international mindfulness and clinical pain management experts to refine an 8-week MBPR program. Phase 2: We recruited participants with cLBP from Northern California using outreach in newsletters, social media, and other methods to test and iteratively modify the curriculum. MBPR was delivered in a group format by videoconference. The first three groups received MBPR; a fourth group was randomized to MBSR or MBPR to assess randomization feasibility. We assessed feasibility and acceptability by attendance, practice logs, and exit interviews. We assessed changes in patient-reported outcome measures for low back pain trials using a single arm (treatment group only) approach at 2 and 6 months with linear mixed models (primary: pain intensity and interference (PEG) scores).</p><p><strong>Results: </strong>Phase 1: The MBPR curriculum included: 1) mindful interoceptive exposure to pain, 2) pain neuroscience education, and 3) yoga postures specifically for cLBP. Phase 2: we enrolled 58 patients in 4 cohorts; 49 completed post-intervention and 41 completed 6-month follow-up assessments; 29 of the 41 received MBPR. Participants attended a mean of 80% of sessions and 23 of 24 participants accepted randomization in the 4th cohort. Mean PEG scores improved for 20 of 29 MBPR participants in a clinically meaningful way (PEG scores >30%).</p><p><strong>Conclusion: </strong>MBPR was feasible and acceptable. Two-thirds of MBPR participants experienced clinically meaningful improvements in pain intensity and interference scores. MBPR warrants further investigation through a randomized, controlled trial.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"785-801"},"PeriodicalIF":2.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in Gut Microbiota Composition Depending on the Site of Pain in Patients with Chronic Pain.","authors":"Yukiko Shiro, Young-Chang Arai, Yuichiro Nakaso, Hiroki Sakurai, Masayuki Inoue, Keiko Owari, Jun Sato, Tatsunori Ikemoto, Takahiro Ushida","doi":"10.2147/JPR.S494984","DOIUrl":"10.2147/JPR.S494984","url":null,"abstract":"<p><strong>Background: </strong>There are many factors associated with chronic pain, including changes in the nervous and musculoskeletal systems and so on. Recently, it has become clear that the gut microbiota (GM) influences these factors, and there are many reports of GM dysbiosis in patients with chronic pain. However, the relationship between pain and GM remains unclear. Our previous study reported that defecation status, which reflects GM composition, was associated with pain intensity and that this relationship was different for each pain site. Our study investigated the association between pain site and the GM composition of feces in chronic pain patients.</p><p><strong>Methods: </strong>The subjects were 136 patients with chronic pain and 125 healthy controls. Patients were classified into four groups, whole body (WB) pain, lower back and lower extremity (LL) pain, headache, and upper back and upper extremity pain, based on the site of pain, and we investigated differences in GM taxonomy groups compared with healthy subject.</p><p><strong>Results: </strong>Chronic pain patients had a lower alpha diversity (effect size=0.16, p=0.02). But each pain site group did not differ in alpha diversity. WB pain patients showed higher Eggerthellaceae (LDA=3.09, p<0.01) and lower Halomonas (LDA =-2.72, p<0.01). LL pain patients had increased Fusobacterium and Sellimonas (LDA=4.09,3.03 p<0.01, 0.01) but reduced Halomonas (LDA=-2.59, p<0.01), and other key taxa.</p><p><strong>Conclusion: </strong>WB and LL patients may have GM compositions different from healthy controls, but larger studies are needed to confirm this.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"769-782"},"PeriodicalIF":2.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, Activity Limitations and Quality of Life in Patients with Non-Specific Neck Pain in Burundi: A Cross-Sectional Study [Response to Letter].","authors":"Gérard Ndacayisaba, Bénit Ndayishima, Jean Mapinduzi, Pierre Ndayishimiye, Alexis Sinzakaraye, Joachim Van Cant","doi":"10.2147/JPR.S520814","DOIUrl":"10.2147/JPR.S520814","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"747-748"},"PeriodicalIF":2.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}