Journal of Pain Research最新文献

{"title":"Effectiveness of Electromagnetic Field Therapy in Mechanical Low Back Pain: A Randomized Controlled Trial [Letter].","authors":"Bibhujit Mishra, Amita Aggarwal, Aarunee Srivastava","doi":"10.2147/JPR.S553133","DOIUrl":"10.2147/JPR.S553133","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"4105-4106"},"PeriodicalIF":2.5,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study of the Safety of Low Temperature Plasma Radiofrequency Ablation on Rat Sciatic Nerve.","authors":"Ke Zhang, Yujie Xu, Tianze Yin, Feng Ji, Hua Xu","doi":"10.2147/JPR.S535883","DOIUrl":"10.2147/JPR.S535883","url":null,"abstract":"<p><strong>Purpose: </strong>Low temperature plasma radiofrequency ablation (LTPRA) has been widely applied for widespread clinical use in a variety of disciplines. However, the safe distance to act in the vicinity of neural tissue has not been determined.</p><p><strong>Methods: </strong>Adult male Sprague-Dawley rats were subjected to LTPRA surgery performed at 0mm, 1mm and 2mm from the sciatic nerve or by cutting only the skin muscle to expose the sciatic nerve. Paw withdrawal thresholds (PWT) were determined at different time points, neurophysiology was examined, and the sciatic nerve was harvested for light and electron microscopic evaluation and Elisa for expression of proinflammatory cytokines and pain-related markers.</p><p><strong>Results: </strong>At 14 days postoperatively, both the 0mm and 1mm groups showed a decrease in PWT, a reduction in the peak amplitude of compound muscle action potentials (CMAPs), a decline in the number of Schwann cells, the area of myelin sheaths, and thinner myelin thickness, additionally, both groups exhibited upregulation of TNF-α, IL-1β, NGF, and C-fos in the sciatic nerve; furthermore, the 0mm group also exhibited slowed nerve conduction velocity, prolonged latency, and myelin vacuolization. The 2mm group exhibited transient reductions in PWT and elevated IL-1β and C-fos at 14 days, and all of these indicators fully recovered on postoperative day 28.</p><p><strong>Conclusion: </strong>LTPRA causes only temporary and reversible changes 2 mm away from the sciatic nerve in rats, which can be recovered within 28 days. This study identifies a 2mm safety threshold for LTPRA to mitigate neurological sequelae, informing surgical guidelines.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"4109-4121"},"PeriodicalIF":2.5,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platelet-Rich Plasma-Induced Analgesia in Peripheral Nerve Repair: Mechanisms, Cautions, and Clinical Promise [Letter].","authors":"Zhiyu Shi, Liyu Shan, Changlong Yang","doi":"10.2147/JPR.S559007","DOIUrl":"10.2147/JPR.S559007","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"4107-4108"},"PeriodicalIF":2.5,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12360382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Borneol's Pre-Clinical Analgesic Efficacy: Mediated by Receptor and Immune Mechanisms.","authors":"Yichen Zhou, Xinyue Mei, Changming Wang","doi":"10.2147/JPR.S533901","DOIUrl":"10.2147/JPR.S533901","url":null,"abstract":"<p><p>Chronic pain affects over 10% of the global population, yet current analgesics face limitations such as addiction and systemic toxicity. Borneol, a traditional Chinese medicine (TCM) with over a millennium history, has emerged as a promising alternative due to its multi-target mechanisms. This review synthesizes preclinical evidence demonstrating borneol's dual analgesic pathways: (1) receptor-mediated actions (eg, TRPM8 activation, GABA agonism) and (2) immune modulation (eg, NF-κB suppression, ROS inhibition). Notably, comparative analysis with menthol reveals borneol's superior TRPM8 specificity and lack of opioid-related side effects. By elucidating these mechanisms, we advocate for borneol's integration into modern pain management strategies, highlighting its potential as a safe, multi-modal therapeutic.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"4085-4104"},"PeriodicalIF":2.5,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Programmed Intermittent Bolus versus Continuous Infusion for Regional Analgesia Following Thoracoscopic Surgery: A Systematic Review and Meta-Analysis.","authors":"Dongqing Ren, Zhilong Liu, Yanjun Gao, Na Xie, Yu Lu, Li Ge","doi":"10.2147/JPR.S530018","DOIUrl":"10.2147/JPR.S530018","url":null,"abstract":"<p><strong>Background: </strong>Continuous regional analgesia techniques have emerged as a more effective alternative for postoperative analgesia, but the clinical efficacy of infusion modes in thoracoscopic surgery remains controversial. This systematic review and meta-analysis to compare the efficacy of programmed intermittent bolus infusion (PIBI) with continuous infusion (CI) for regional analgesia in patients undergoing thoracoscopic surgery.</p><p><strong>Methods: </strong>We searched PubMed, Embase, Web of Science, and the Cochrane Library for relevant research from inception to March 2025. Randomized controlled trials (RCTs) comparing PIBI with CI for regional analgesia following thoracoscopic surgery were included. The meta-analysis was made by using ReMan 5.4 software.</p><p><strong>Results: </strong>We included 7 RCTs with 394 patients. For resting VAS at 6 h, there was no significant difference between PIBI and CI (MD = -0.52, 95% CI: -1.23 to 0.20). PIBI was more likely to reduce the resting VAS at 12 h, movement VAS at 12 h, and morphine consumption in first 24 h. PIBI had lower local anesthetic consumption and wider range of sensory blockade than CI. However, there were no significant difference between PIBI and CI in terms of the resting VAS at 24 h, resting VAS at 48 h, movement VAS at 6 h, movement VAS at 24 h, movement VAS at 48 h, morphine consumption in second 24 h, and number of people using additional analgesics.</p><p><strong>Conclusion: </strong>PIBI provided a lower local anesthetic consumption and a wider sensory blockade compared to CI for regional analgesia following thoracoscopic surgery, although no significant clinical differences were observed in postoperative pain scores, opioid consumptions, and number of people using additional analgesics.</p><p><strong>Limitation: </strong>The heterogeneity may influence the pooled estimates, the conclusion was only suitable for pulmonary surgery, the lack of long-term follow-up data on chronic pain outcomes.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"4073-4083"},"PeriodicalIF":2.5,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Pain Clinical Specialists' Perspectives on Opioid Optimization for Chronic Non-Malignant Pain in England.","authors":"Aziza Alenezi, Vibhu Paudyal, Asma Yahyouche","doi":"10.2147/JPR.S512418","DOIUrl":"10.2147/JPR.S512418","url":null,"abstract":"<p><strong>Background: </strong>The use of opioids for chronic non-malignant pain (CNMP) offers limited efficacy and carries the potential for addiction. Healthcare professionals in both primary and secondary care settings face challenges when attempting to optimise opioid medications. There are limited studies that investigated the barriers and enablers to opioid reduction, cessation, and optimisation, specifically from a pain clinical specialist perspective.</p><p><strong>Objective: </strong>This study explores pain clinical specialists' views on challenges in opioid prescription management-including optimization and tapering-and their interactions with patients and prescribers.</p><p><strong>Methods: </strong>Participants were recruited through pain clinic, webinars Email outreach, and professional networks. Semi-structured interviews were conducted using a guide based on the Theoretical Domains Framework (TDF) with 11 pain clinical specialists (8 consultants and 3 pharmacists) from NHS England, out of 15 participants who initially expressed interest, recruited via professional networks. Thematic analysis employed Framework Approach with dual coding.</p><p><strong>Key findings: </strong>Eleven participants, comprising eight pain doctors and three clinical pharmacists, provided insights. Analysis revealed four key findings: (1) A paradigm shift away from long-term opioid therapy due to concerns about dependency and inadequate pain relief; (2) Strong preference for multidisciplinary, personalized treatment approaches; (3) Significant system-level barriers including care fragmentation and inadequate consultation time; (4) Critical need for enhanced clinician training and patient education programs.</p><p><strong>Conclusion: </strong>Optimizing opioid use for CNMP requires fundamental changes to current practice, including implementation of integrated care pathways, extended consultation times, and comprehensive education initiatives. These findings provide evidence-based recommendations for improving pain management while reducing inappropriate opioid prescribing.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"4037-4051"},"PeriodicalIF":2.5,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of Aromatherapy on Pain and Anxiety During Needle-Related Procedures in Adults: A Systematic Review and Meta-Analysis.","authors":"Chenxi Sun, Changdong Fei, Ronghua Lin, Xueling Qiu, Weifeng Wang, Xiaochen Jiang, Fan Sun, Yuchen Wang, Lu Tang","doi":"10.2147/JPR.S533076","DOIUrl":"10.2147/JPR.S533076","url":null,"abstract":"<p><strong>Background: </strong>Pain and anxiety resulting from needle-related manipulation are major causes of patient refusal and missed optimal treatment. This study focuses on assessing the effectiveness and benefits of aromatherapy in adult patients undergoing needle-related manipulation for pain and anxiety.</p><p><strong>Methods: </strong>The researchers conducted detailed searches of a total of five databases, the Cochrane Library, Web of Science, Embase Databases, and Scopus, from the period of the library's construction until November 23, 2024. Inclusion criteria involved adults undergoing needle-related manipulation, aromatherapy as an intervention, and outcome indicators such as pain, anxiety, and satisfaction. And the results were analyzed in subgroups. This study used RevMan 5.4.1 software to analyse the included data.</p><p><strong>Results: </strong>This meta-analysis and systematic review included a total of 9 studies. A meta-analysis demonstrated that aromatherapy as an intervention significantly reduced pain (MD = -1.82, 95% CI [-2.35, -1.30], p < 0.00001) and anxiety (SMD = -0.92, 95% CI [-1.71, -0.14], p = 0.02) in adult patients undergoing needle-related invasive procedures compared to placebo and conventional interventions. Subgroup analyses indicated aromatherapy reduced pain during needle procedures for arteriovenous fistulae (AVF) and catheter placement, and alleviated anxiety in AVF patients. Lavender oil effectively reduced both pain and anxiety. The 5-minute duration of action is superior to the 3-minute duration of action. Both inhalation and topical application reduced pain.</p><p><strong>Conclusion: </strong>This meta-analysis supports aromatherapy for needle-related pain relief and targeted anxiety reduction. However, protocol standardization in future RCTs is needed to address high heterogeneity and methodological limitations.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"4053-4072"},"PeriodicalIF":2.5,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Musculoskeletal Pain Management in the General Practitioner's Office & E-Referral: A Multidisciplinary Expert Opinion.","authors":"Fabrizio Gervasoni, Giacomo Farì, Massimiliano Franco, Sara Liguori, Luca Maschietto, Raffaella Michieli, Emanuela Raimondo, Dalila Scaturro, Giuseppe Ventriglia, Alberto Magni","doi":"10.2147/JPR.S515501","DOIUrl":"10.2147/JPR.S515501","url":null,"abstract":"<p><strong>Purpose: </strong>Musculoskeletal pain (MP) is a significant burden in primary care, often presenting challenges for general practitioners (GPs) in providing timely and effective management. Despite MP's prevalence, GPs face limitations in diagnostic resources and access to specialists, which can delay intervention and increase the risk of pain chronicity. This multidisciplinary expert opinion aims to establish a structured approach for the management of MP within general practice, using three targeted algorithms: (1) early management of acute MP in the GP's office, (2) post-surgical MP management to support recovery, and (3) MP management following emergency discharge.</p><p><strong>Patients and methods: </strong>A panel of GPs, physiatrists, and orthopedists collaborated to develop practical recommendations based on current clinical guidelines, emphasizing early diagnosis, initial pain control, and effective e-referral pathways. During an onsite meeting, they created an algorithm to identify waiting therapy for patients with pain, in order to help GPs in this difficult task.</p><p><strong>Results: </strong>The first algorithm focuses on early intervention for acute MP in primary care, with recommendations for both pharmacological and non-pharmacological approaches. The second algorithm addresses post-surgical MP management to enhance recovery and reduce complications. The third algorithm outlines post-emergency management strategies, emphasizing immediate pain relief and integrating patient education to support home management. E-referral and teleconsultation are incorporated throughout to enhance care coordination.</p><p><strong>Conclusion: </strong>These three algorithms provide a structured framework for MP management in primary care, placing GPs at the centre of early intervention. The inclusion of telemedicine and e-referral pathways allows for timely specialist input, ultimately aiming to improve patient outcomes and minimize chronic pain risks.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3879-3889"},"PeriodicalIF":2.5,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonic Bone Scalpel vs Turbine Drill in Mandibular Third Molar Extraction: Impact on Postoperative Pain and Inflammation.","authors":"Ge Wang, Hui Wang, Jie Xu, Xiaoyan Zhang","doi":"10.2147/JPR.S534667","DOIUrl":"10.2147/JPR.S534667","url":null,"abstract":"<p><strong>Objective: </strong>To compare postoperative outcomes between ultrasonic bone scalpel and turbine drill techniques for impacted mandibular third molar extraction, focusing on pain, inflammation, and recovery parameters.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed 109 patients treated between 2020 and 2022, divided into an ultrasonic group (n=55; piezoelectric osteotomy) and a turbine group (n=54; high-speed drilling). Primary outcomes included operative time, intraoperative blood loss, facial swelling, maximum mouth opening, and pain scores assessed using the Visual Analog Scale (VAS) at 6, 24, and 72 hours postoperatively. Gingival crevicular fluid samples were collected preoperatively and on postoperative day 3 to quantify levels of calcitonin gene-related peptide (CGRP), substance P (SP), serotonin (5-hydroxytryptamine, 5-HT), tumor necrosis factor-alpha (TNF-α), intercellular adhesion molecule-1 (ICAM-1), and myeloperoxidase (MPO).</p><p><strong>Results: </strong>The ultrasonic group demonstrated 35% shorter operative time (20.04 vs 31.06 min; P<0.001, Cohen's d=2.84), 21% less blood loss (7.94 vs 10.01 mL; P<0.001, d=2.95), significantly lower VAS scores at 24h (3.25 vs 3.65; P=0.036) and 72h (0.52 vs 0.85; P=0.009), and 40% reduced analgesic use (2.1 vs 3.5 tablets; P<0.001), alongside biomarker reductions including 41% lower CGRP and 33% lower TNF-α (P<0.001).</p><p><strong>Conclusion: </strong>The ultrasonic bone scalpel demonstrates superior clinical outcomes including reduced operative duration, attenuated pain/inflammation, and faster recovery, though limitations include retrospective design and short-term follow-up.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"4029-4036"},"PeriodicalIF":2.5,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Dexmedetomidine as an Adjuvant to Ropivacaine for Intercostal Nerve Block in Elderly Patients Undergoing Video-Assisted Thoracoscopic Esophagectomy: A randomized Double-Blinded Trial.","authors":"Fayin Li, Pengfei Gao, Xianlong Zhang","doi":"10.2147/JPR.S542327","DOIUrl":"10.2147/JPR.S542327","url":null,"abstract":"<p><strong>Background: </strong>Esophagectomy is associated with significant postoperative pain and a pronounced perioperative stress response. Dexmedetomidine (DEX) has been widely recognized as an effective adjuvant to regional anesthesia across various surgical procedures. However, its efficacy and safety as an adjuvant to ropivacaine in elderly patients undergoing thoracoscopic esophagectomy remain unclear. This study aimed to evaluate the effectiveness and safety of DEX.</p><p><strong>Methods: </strong>A total of 89 patients with the American Society of Anesthesiologists (ASA) physical status I-III were randomly assigned to two groups. The DR group received an intercostal nerve block with a mixture of 20 mL of 0.25% ropivacaine and 2 μg/kg of DEX, while the RP group received 20 mL of 0.25% ropivacaine alone. Plasma levels of epinephrine (E), norepinephrine (NE), and cortisol (COR) were measured perioperatively. Postoperative analgesia was assessed using the Visual Analog Scale (VAS), the cumulative dose of rescue analgesics, and the pump pressure required for rescue analgesia. Additionally, adverse events and satisfaction scores from both patients and thoracic surgeons were recorded. The Shapiro-Wilk test was applied for uniformly distributed. The values for baseline information were presented as the mean ±standard (SD), and compared using one-way ANOVA. Enumeration data were expressed as percentages or frequencies and compared using the Chi-square test.</p><p><strong>Results: </strong>Postoperatively, plasma levels of E, NE, and COR decreased significantly in the DR group compared to the RP group. The duration of analgesia was longer in the DR group, with fewer requirements for rescue analgesia and a significantly extended time to the first analgesic request. VAS scores were significantly lower in the DR group. No significant adverse events were observed, and patient satisfaction with analgesia was significantly higher in the DR group.</p><p><strong>Conclusion: </strong>DEX, when used as an adjuvant to intercostal nerve block, prolongs analgesic duration, improves pain control, and attenuates the perioperative stress response in elderly patients undergoing thoracoscopic esophagectomy.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"4019-4027"},"PeriodicalIF":2.5,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12357599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}