Journal of Pain Research最新文献

{"title":"Manipulative Treatment of Myofascial Pain Syndrome: A Network Meta-Analysis Based on Randomized Controlled Trials.","authors":"Jing Chen, Linyu Yin, Qing Hu, Songtao Liu, Lirong Zeng","doi":"10.2147/JPR.S517869","DOIUrl":"https://doi.org/10.2147/JPR.S517869","url":null,"abstract":"<p><strong>Objective: </strong>Myofascial pain syndrome (MPS) is a common condition. Manual therapy is preferred over other invasive treatments due to its noninvasiveness and safety, but evidence for its effectiveness is lacking. We here conducted a comprehensive search of randomized controlled trial studies related to manipulative therapy for MPS and conducted a network meta-analysis to provide a basis for clinical applications and experimental studies.</p><p><strong>Methods: </strong>Reports on randomized controlled trials of noninvasive therapy for MPS deposited in the China National Knowledge Infrastructure database, Chinese Science Citation Database(CSCD), Chinese Citation Database(CCD), Chinese Biomedical Database, PubMed, Embase, Cochrane Library, and Web of Science from their respective inception dates until November 10, 2024, were retrieved. A network meta-analysis was performed using Rv4.2.0 software.</p><p><strong>Results: </strong>Fourteen studies involving 588 patients overall were included. The interventions included pain point compression, massage, and ischemic compression. Visual analogue scale scores were reported in 12 studies and the pressure pain threshold was reported in five studies. The outcomes demonstrated that manipulation had a notable effect, although not statistically significant, as compared with conventional treatment and placebo. Overall, the effect of pain-point compression was favorable. The results were stable, with no significant publication bias.</p><p><strong>Conclusion: </strong>Manipulation was an effective treatment for MPS, but the effects were not statistically significant, based on the findings of this study. Owing to issues such as uneven methodological quality and the small sample size of the included studies, further high-quality multicenter, large-sample, randomized double-blind controlled trials are required to verify the reliability of this conclusion.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1923-1933"},"PeriodicalIF":2.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postulate of the Existence of a 'Nocistat': Rationale and Implications for Novel Analgesics.","authors":"Robert B Raffa, Wolfgang Fink, Anuj D Tripathi","doi":"10.2147/JPR.S524175","DOIUrl":"https://doi.org/10.2147/JPR.S524175","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1945-1947"},"PeriodicalIF":2.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LASSO Logistic Regression for Predicting Postoperative Severe Pain After Hepatic Hemangioma Ablation.","authors":"Ruize Gao, Fei Xu, Yuntang Song, Shan Ke, Jian Kong, Shaohong Wang, Wenbing Sun, Jun Gao","doi":"10.2147/JPR.S510668","DOIUrl":"https://doi.org/10.2147/JPR.S510668","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a least absolute shrinkage and selection operator (LASSO) logistic regression to predict postoperative severe pain after thermal ablation of hepatic hemangioma (HH).</p><p><strong>Patients and methods: </strong>From January 2014 to March 2024, 285 patients with HH treated by thermal ablation were retrospectively recruited. Forty-seven patients with postoperative severe pain [visual analogue scale (VAS) score ≥ 5] were matched 1:2 with 94 patients with mild pain (VAS score < 5). The LASSO and multivariate logistic regression identified independent risk factors for severe pain after thermal ablation for HH. The model's performance was evaluated using receiver operating characteristic (ROC) curves, calibration plots, and decision curve analysis (DCA). Internal validation was performed using the Bootstrap method.</p><p><strong>Results: </strong>The ablation time (OR = 1.070, p = 0.046), postoperative levels of aspartate aminotransferase (AST) (OR = 1.012, p < 0.001), lactate dehydrogenase (LDH) (OR = 1.009, p = 0.001), neutrophil to lymphocyte ratio (NLR) (OR = 1.266, p = 0.034) were independent risk factors of severe pain. The model's area under the curve (AUC) = 0.985 (95% CI, 0.971-0.998). After internal verification by the Bootstrap method, the model still had a high discriminative ability (AUC = 0.979, 95% CI, 0.971-0.985). The calibration curve illustrated good agreement between the predicted and observed probability of severe pain. DCA verified that the model possesses significant predictive value.</p><p><strong>Conclusion: </strong>Our nomogram predicts postoperative severe pain for HH with good discrimination and calibration based on the easily available risk factors.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1909-1921"},"PeriodicalIF":2.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Durability of Supplemental Nucleus Pulposus Allograft in Patients with Lumbar Discogenic Pain.","authors":"Shrif Costandi, Douglas P Beall, Timothy T Davis, Kasra Amirdelfan, Ramana K Naidu, Michael J DePalma, Edward S Yoon, Jacob W Fleming, Jon E Block, Nagy Mekhail","doi":"10.2147/JPR.S516571","DOIUrl":"https://doi.org/10.2147/JPR.S516571","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to determine the degree of improvement in lumbar discogenic pain severity and associated back impairment in patients with chronic axial low back pain treated with intradiscally delivered allogeneic nucleus pulposus (NP) at up to two vertebral levels (L1-S1).</p><p><strong>Methods: </strong>Prospective, single-arm clinical study conducted at 6 sites in the US involving 28 participants with discogenic pain (mean age: 44 ± 13 yrs) and modified Pfirrmann grade 3-7 on magnetic resonance imaging. This report includes the final participant follow up at 24 months post procedure. Back pain severity was evaluated using an 11-point numeric rating scale (NRS) and back function using the Oswestry Disability Index (ODI). Minimal clinically important difference (MCID) and substantial clinical benefit (SCB) were set at ≥30% and ≥50% over baseline, respectively. The patient acceptable symptom state (PASS) threshold for pain severity was ≤3.</p><p><strong>Results: </strong>The average improvement in back pain severity from 7.1 ± 1.6 at baseline to 3.6 ± 2.9 at 24 months was 43% (p<0.001). Approximately 64% (14 of 22) of participants achieved both the MCID and SCB in back pain at 24 months, while nearly 55% (12 of 22) reported a 24-month back pain severity score of ≤3. The corresponding average decrease in ODI values was 53% (p<0.001) with 73% (16 of 22) of participants achieving the MCID. At baseline approximately 82% (23 of 28) of participants reported severe or crippled back impairment compared to 18% (4 of 22) at 24 months (p<0.001). There was no association between modified Pfirrmann grade, number of levels treated or Modic changes and any outcome (range: p=0.12 to 0.43).</p><p><strong>Conclusion: </strong>This study provides evidence of clinically significant pain relief and functional improvement through 24 months of follow up after a single allogeneic NP supplementation procedure in patients with lumbar discogenic pain.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1901-1908"},"PeriodicalIF":2.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Closed Irrigation and Drainage vs Repeated Wound Dressing Changes for Iliac Crest Bone Donor Site Infection in Spine Surgery.","authors":"Xiaodan Li, Qiang Xiao, Ji-Huan Zeng","doi":"10.2147/JPR.S511091","DOIUrl":"https://doi.org/10.2147/JPR.S511091","url":null,"abstract":"<p><strong>Objective: </strong>Bone donor site infection (BDSI) is a main complication of bone harvest in spine surgery. Traditionally, repeated wound dressing changes (RWDC) after debridement are commonly used to treat BDSI but are associated with significant pain and largely prolonged hospitalization. This study retrospectively compared the effectiveness of closed irrigation and drainage (CIAD) with RWDC in treating BDSI.</p><p><strong>Methods: </strong>A total of 21 cases of BDSI secondary to different spinal procedures in a period of 15 years were included. Twelve cases were treated by RWDC in the earlier study period, and the other 9 cases were treated by CIAD in the later period. Detailed information about pre- and intra-operative characters, laboratory results, pathogens results, duration of antibiotics use, visual analog scale (VAS) score of donor site pain, total hospital stay, cost after primary operation, and final outcomes of the BDSI were collected.</p><p><strong>Results: </strong>No significant difference was found among the included baseline characters. All patients obtained wound healing and no reinfection was found during a minimum of one year's follow-up. However, compared to RWDC, CIAD was associated with reduced hospital stay (16.5 ± 3.8 days versus 23.7 ± 4.9 days, P < 0.05), shorter duration of antibiotic use (5.3 ± 1.7 weeks versus 6.7 ± 2.0 weeks) and lower medical cost after primary operation (5040 ± 678 yuan versus 7280 ± 701 yuan, P < 0.05). While the VAS scores of donor site pain on the day a BDSI was diagnosed did not differ in the two groups, they were significantly lower on day 3, day 7, and even on the discharge day in the CIAD group.</p><p><strong>Conclusion: </strong>CIAD displays significant superiority to RWDC for the treatment of BDSI in terms of hospital stay, antibiotic duration, cost, and pain relief.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1935-1943"},"PeriodicalIF":2.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Ultrasound-Guided Iliohypogastric and Ilioinguinal Nerve Block for Anesthesia in Pediatric Inguinal Surgery.","authors":"Pan Li, Wen Tang","doi":"10.2147/JPR.S505650","DOIUrl":"https://doi.org/10.2147/JPR.S505650","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the efficacy of ultrasound-guided iliohypogastric and ilioinguinal nerve block for anesthesia in pediatric inguinal surgery.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on a cohort of 100 pediatric patients undergoing unilateral inguinal region surgeries at Chongqing Medical University Children's Hospital from July to December 2019. The participants were stratified into two groups: Groin group and Navel-iliac group, each consisting of 50 patients. Key parameters including hemodynamics, respiratory dynamics, blood oxygen saturation, surgical and anesthesia-specific metrics, intraoperative and postoperative complications, postoperative pain management, and parental satisfaction were subjected to meticulous statistical scrutiny.</p><p><strong>Results: </strong>Significantly divergent outcomes were observed between the Groin and Navel-iliac groups at T2 and T3. The Groin cohort displayed markedly lower heart rates, respiratory rates, mean arterial pressures, blood pressures, and blood oxygen saturation levels in comparison to the Navel-iliac group (P<0.05). Furthermore, the Groin group exhibited shorter awakening times and reduced post-anesthesia care unit stays (P<0.05), along with decreased usage of sufentanil and propofol (P<0.05). Noteworthy reductions in the occurrences of intraoperative movement, postoperative nausea and vomiting, and postoperative agitation were noted in the Groin group (P<0.05). The FLACC pain scores upon awakening and at the 2-hour postoperative mark were also notably lower in the Groin group (P<0.05). Parental satisfaction within the Groin group was notably higher at 98.00% (49/50) compared to the Navel-iliac group's 80.00% (40/50) (χ2=8.274, P<0.05). All children involved in the study and their legal guardians signed written informed consent after fully understanding the study.</p><p><strong>Conclusion: </strong>The modified ultrasound-guided iliohypogastric and ilioinguinal nerve block is more effective than the traditional ultrasound-guided method for anesthesia in pediatric inguinal surgery. The Groin group method provides a safe and effective anesthesia, particularly for children with a low body mass index (BMI<13.9).</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1891-1899"},"PeriodicalIF":2.5,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11992982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Modalities for Aromatase Inhibitor-Associated Musculoskeletal Syndrome (AIMSS): A Scoping Review of Prospective Treatment Studies.","authors":"Justin Andrew Bobo, Barbara Lubrano, Raul Rosario-Concepcion, Alejandra Cuartas-Abril, Pooja Advani, Saranya Chumsri, Barbara K Bruce","doi":"10.2147/JPR.S492891","DOIUrl":"https://doi.org/10.2147/JPR.S492891","url":null,"abstract":"<p><p>Aromatase inhibitors (AI's) are effective adjuvant treatments for postmenopausal patients with hormone receptor-positive breast cancer. However, AIs are often associated with diffuse joint and muscle pain, referred to as aromatase inhibitor-associated musculoskeletal syndrome (AIMSS), the symptoms of which are associated with negative impacts and reduced adherence to AI therapy. As more interventions for AIMSS continue to be investigated, a scoping review is needed to survey and summarize the types of interventions and outcomes assessed in studies conducted to date, which may help identify areas needing attention or additional focus in future research. Online databases were searched (from inception to January 8, 2025) to identify 74 reports from prospective studies of interventions for AIMSS pain, stiffness, or interference with functioning. Such interventions were classified as pharmacological (14 reports), complementary/alternative (43 reports), or rehabilitative (17 reports). Included papers required the presence of AIMSS symptoms at enrollment. Several interventions were deemed promising for reducing AIMSS symptoms based on positive results from individual reports, including duloxetine (3 reports from 2 studies), vitamin B12 (2 reports), vitamin D (2 reports), calcitonin (1 report), prednisolone (1 report), glucosamine and chondroitin (1 report), various mind-body (14 reports from 12 studies) and traditional medicine interventions (3 reports), and switching to another AI (1 report). Many positive findings were from uncontrolled studies or were from single studies that await replication in independent cohorts, and no studies focused on structured psychological interventions. The durations for all reviewed studies were brief relative to the expected 5-10-year course of AI therapy. Intervention effects on a wide range of outcomes were studied, including pain or stiffness (70 reports), functioning/disability (34 reports), quality of life (37 reports), mental health symptoms (25 reports), pain self-efficacy (4 reports), and AI persistence (3 reports). However, intervention effects on other important endpoints such as cancer recurrence, survival, healthcare utilization/costs, and caregiver experiences are unclear. The knowledge gaps and limitations identified in this scoping review constitute areas in urgent need of further research and attention.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1853-1889"},"PeriodicalIF":2.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11989607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Degeneration of Paraspinal Muscles and Its Correlation with the Postoperative Clinical Outcomes Following Minimally Invasive Transforaminal Lumbar Interbody Fusion (MIS-TLIF).","authors":"Weiran Hu, Kai Zhang, Xinge Shi, Guang Yang, Ang Li, Yanzheng Gao","doi":"10.2147/JPR.S506153","DOIUrl":"https://doi.org/10.2147/JPR.S506153","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to analyze the degeneration of paraspinal muscles after minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) surgery and its correlation with clinical outcome.</p><p><strong>Methods: </strong>Retrospective analysis was conducted on data from patients who underwent single-segment MIS-TLIF surgery in our hospital. MRI examinations were performed before the operation, at 6 months, and at 12 months after the operation to evaluate changes in volume and steatosis of the psoas major muscle and lumbar posterior muscles. VAS scores and ODI were filled out at 12 months after the operation, and correlations between psoas volume, posterior muscle volume, steatosis rate, and clinical outcome were analyzed.</p><p><strong>Results: </strong>After surgery, both the psoas major muscle and dorsal muscles of fused segments showed atrophy. The steatosis in the fusion segment improved significantly at 12 months compared to 6 months after surgery (29.7±8.2 vs 20.6±6.1, P<0.05), while there was no improvement in adjacent segment muscle steatosis during the follow-up period. VAS score was strongly negatively correlated with lumbar posterior muscle of fused segments (r=-0.819, P < 0.001), strongly positively correlated with steatosis of fused segments (r=0.868, P < 0.001), and moderately negatively correlated with psoas major muscle of fused segments (r=-0.435). ODI index was moderately negatively correlated with lumbar posterior muscles (r=-0.-512, P=0-004) as well as psoas major muscles (r=-0402, P<005). ODI index also had a moderate negative correlation with adjacent dorsal muscles (r=-0478, P=002).</p><p><strong>Conclusion: </strong>Continuous atrophy was observed in both psoas major muscle and lumbar posterior muscles of fused segments as well as adjacent segments. However, by the end of the 12-month period after the operation, an improvement in fatty degeneration was noted specifically in the lumbar posterior muscles of the fused segment. The volume and steatosis rate of lumbar posterior muscles were found to have a significant correlation with clinical outcome.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1827-1836"},"PeriodicalIF":2.5,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese Rehabilitation Exercise (TCRE) for Myofascial Pain-A Superficial Synthesis with Missed Opportunities [Letter].","authors":"Zhidong Zhou, Qiang Liu","doi":"10.2147/JPR.S530200","DOIUrl":"https://doi.org/10.2147/JPR.S530200","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1851-1852"},"PeriodicalIF":2.5,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Propranolol and Psychologically Informed Intervention on Pain Sensitivity: Secondary Analysis from the Biopsychosocial Influence on Shoulder Pain Preclinical Randomized Trial.","authors":"Mark D Bishop, Corey B Simon, Yanan Huo, Margaret R Wallace, Paul A Borsa, Roger B Fillingim, Roland Staud, Samuel S Wu, Steven Z George","doi":"10.2147/JPR.S500140","DOIUrl":"https://doi.org/10.2147/JPR.S500140","url":null,"abstract":"<p><strong>Purpose: </strong>Measures of pain sensitivity have potential relevance for patient care. We previously identified a subgroup of people at risk for ongoing pain characterized by genetic AND psychological factors. Here, we report planned secondary analyses examining the effect of personalized interventions on pain sensitivity outcomes.</p><p><strong>Patients and methods: </strong>Two hundred and sixty-one healthy individuals with the COMT SNP rs6269 AA genotype and Pain Catastrophizing Scale scores of 5 or higher received exercise-induced muscle injury, followed by a randomly assigned treatment: (1) general education and placebo; (2) personalized psychological intervention and placebo; (3) general education and propranolol; or (4) personalized psychological intervention and propranolol. Pain sensitivity outcomes (pressure pain thresholds (PPT), suprathreshold heat rating, temporal summation, and conditioned pain modulation efficiency) were compared using a mixed effect model to examine difference among groups, adjusted for age, sex and race.</p><p><strong>Results: </strong>No main effects for group assignment were noted (p > 0.05 for all), when considered as 4 groups or 2 collapsed groups (ie propranolol vs placebo or personalized psychologic vs general education). Interaction terms were then entered into our models in an exploratory fashion. For PPT outcomes interactions were noted for, sex and time, and race and time (p<0.015). For temporal summation outcomes, interactions were noted for sex and group and race and group (p < 0.015).</p><p><strong>Conclusion: </strong>Results indicated no statistically reliable changes in pain sensitivity when considering matched vs unmatched treatment groups. Caution is needed in this interpretation given that the trial was not powered to specifically identify these differences. Exploratory analysis of interactions among ethnic/racial and gender identities by treatment, however, showed the potential for differential effects for specific pain sensitivity measures. Significant interactions across modalities suggest analysis of higher order interactions/intersectionality could be of great interest for testing efficacy of personalized interventions in future trials.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1837-1850"},"PeriodicalIF":2.5,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}