Journal of Pain Research最新文献

{"title":"Effectiveness of Jingjin Therapy for Non-Specific Chronic Neck Pain with Extension Dysfunction: A Randomised Controlled Trial.","authors":"Zhichao Gong, Yinyan Gao, Wenqi Liu, Wu Li, Xinyin Wu, Jiangshan Li","doi":"10.2147/JPR.S515232","DOIUrl":"10.2147/JPR.S515232","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate whether Jingjin therapy, a distal manual intervention, could accelerate extension dysfunction for non-specific chronic neck pain (NCNP).</p><p><strong>Patients and methods: </strong>In this single-centre, two-arm randomised controlled trial, we enrolled Chinese patients aged 20-60 years with active neck extension disorder, regardless of prior exposure to manual therapy. We randomly assigned 160 patients to one of the following two arms: Jingjin therapy or general manual therapy. Both groups underwent six treatment sessions: the first three sessions were administered daily, and the last three sessions were administered every other day. The primary outcome was the between-group difference in the angle of active neck extension after the sixth treatment and 1 week after treatment. A repeated-measures linear mixed-effects model was used to assess between-group differences in outcome indices, with group allocation and treatment time points treated as fixed effects and participants as random effects.</p><p><strong>Results: </strong>The change in the angle of active neck extension from baseline to the sixth treatment session was significant for Jingjin therapy (mean: 29.75° to 51.97°) and general manual therapy (mean: 28.18° to 52.49°). Further, the between-group difference was minimal (mean -0.26°, 95% confidence interval, -2.62°, 2.09°) and not statistically significant (<i>P</i> = 0.828).</p><p><strong>Conclusion: </strong>Jingjin therapy for 9 days significantly improved neck extension function in patients with NCNP, with no significant difference compared to general manual therapy.</p><p><strong>Clinical trial registry id: </strong>ChiCTR2300068892.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2631-2642"},"PeriodicalIF":2.5,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectory of Self-Reported Pain and Association with Quality of Life in Patients with Perianal Abscesses After Surgery.","authors":"Yulei Gao, Li Zhang, Qiao Qian, Huachun Zhang, Yibo Yao","doi":"10.2147/JPR.S492923","DOIUrl":"10.2147/JPR.S492923","url":null,"abstract":"<p><strong>Background: </strong>Perianal abscesses are a common anorectal condition characterized by painful collections of pus near the anus and rectum. Surgical intervention is the standard treatment, yet postoperative pain can significantly impact patients' quality of life (QoL). Understanding the variability in pain experiences and their association with QoL is crucial for improving postoperative outcomes.</p><p><strong>Methods: </strong>This study included 575 patients who underwent surgical intervention for perianal abscesses between 2021 and 2023. Pain intensity was assessed using the Visual Analog Scale at multiple time points over a four-week follow-up period. QoL was measured using the Short Form-36 health Survey. Group-based trajectory modeling was employed to identify distinct pain trajectories. Multivariate linear regression analyses examined the association between pain trajectories and QoL, adjusting for demographic, lifestyle, and clinical covariates.</p><p><strong>Results: </strong>Group-based trajectory modeling identified three distinct pain trajectories. Compared to participants in the fluctuating group, patients in trajectories characterized by gradual decline (β=5.17; 95% confidence interval: 2.44, 7.91) or rapid decline (β=5.19; 95% confidence interval: 2.48, 7.90) pain reported significantly higher QoL scores across SF-36 score at 4 weeks post-surgery.</p><p><strong>Conclusion: </strong>The study highlights the heterogeneity in postoperative pain experiences among patients with perianal abscesses and underscores the importance of personalized pain management strategies. Early identification of patients at risk of poor pain outcomes can facilitate targeted interventions, ultimately improving long-term QoL.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2615-2622"},"PeriodicalIF":2.5,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12108952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indolepropionic Acid Attenuates CFA-Induced Inflammatory Pain in Mice.","authors":"Rui-Feng Ao, Heng-Rui Yong, Ying-Tao Hu, Yu-Sheng Huang, Jia-Wen Gao, Chen Tu, Jing-Shen Zhuang, Zhao-Ming Zhong","doi":"10.2147/JPR.S525859","DOIUrl":"10.2147/JPR.S525859","url":null,"abstract":"<p><strong>Background: </strong>Chronic pain is a global health issue that affects as many as 20% of the population. Inflammatory pain, an important form of chronic pain, negatively impacts patients' quality of life. Indolepropionic acid (IPA), a metabolite derived from the gut microbiota, has anti-inflammatory properties. However, its effect on inflammatory pain has not yet been explored. This study aims to investigate the impact of IPA on CFA-induced inflammatory pain.</p><p><strong>Methods: </strong>A mouse model of inflammatory pain was established by injection of Complete Freund's Adjuvant (CFA) into the hind paw, and treated with the IPA supplement. Behavioral assessments were conducted using the Von Frey test, cold or hot plate tests. The expression of pain-related transcripts, such as transient receptor potential vanilloid 1 (TRPV1) and calcitonin gene-related peptide (CGRP) was evaluated. Degree of inflammation was assessed by the thickness of paws, degree of inflammatory infiltration and the changes of serum tumor necrosis factor (TNF)-α, interleukin(IL)-6 and IL-1β.</p><p><strong>Results: </strong>IPA supplement improved the CFA-induced decrease of the mechanical withdrawal threshold and cold and thermal withdrawal latency. Meanwhile, IPA inhibited the CFA-induced upregulation of TRPV1 and CGRP in DRGs. In addition, IPA treatment also suppressed the CFA-induced local and systemic inflammation, including the swelling and thickening of the paw, local infiltration of inflammatory cells, and increased serum levels of TNF-α, IL-6, and IL-1β.</p><p><strong>Conclusion: </strong>Our results show that IPA can improve pain-related behavior and alleviate inflammation in the CFA-treated mice, which provides new insight into potential strategies for inflammatory pain management.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2643-2650"},"PeriodicalIF":2.5,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five Critical Queries on Network Meta-Analysis: \"Effective Yet Insignificant\" Manipulative Therapy for Myofascial Pain Syndrome? [Response to Letter].","authors":"Jing Chen, Qing Hu, Linyu Yin, Lirong Zeng, Songtao Liu","doi":"10.2147/JPR.S539815","DOIUrl":"10.2147/JPR.S539815","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2613-2614"},"PeriodicalIF":2.5,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating Pregnancy Testing in Chronic Pain Management for Women of Reproductive Age.","authors":"Shoran Tamura, Swarnima Vardhan, Kathryn Breidenbach, Naum Shaparin, Amaresh Vydyanathan, Karina Gritsenko","doi":"10.2147/JPR.S510703","DOIUrl":"10.2147/JPR.S510703","url":null,"abstract":"<p><strong>Background: </strong>Women of childbearing age often require a nuanced and individualized approach to chronic pain management, especially when pregnancy is a possibility. Interventional procedures involving ionizing radiation, such as fluoroscopy-guided injections, raise specific concerns for fetal safety, including risks of embryo death, congenital anomalies, intellectual disability, and microcephaly. Despite national recommendations from organizations like the American College of Radiology (ACR), implementation of pregnancy screening in the pain management context remains limited.</p><p><strong>Methods: </strong>This review synthesizes current literature and practice guidelines to assess the gaps in pregnancy screening protocols within chronic pain management settings. It highlights challenges in evaluating pregnancy status before initiating pharmacologic or fluoroscopic procedures, and it examines both biological testing limitations and procedural risks.</p><p><strong>Results: </strong>Fluoroscopically guided procedures may exceed the teratogenic radiation threshold of 50 mGy, underscoring the critical need for reliable pregnancy screening. While urine and serum hCG tests are widely used, both are susceptible to false negatives and positives due to timing, hormone variants, and analytical interferences. Integrating clinical evaluation with menstrual history, point-of-care testing, and serum confirmation may improve diagnostic accuracy and ensure greater protection for the fetus.</p><p><strong>Conclusion and recommendations: </strong>To address safety concerns, this review proposes a structured pregnancy screening algorithm tailored for chronic pain practices. Key recommendations include: routine screening of all reproductive-age women prior to procedures involving radiation or teratogenic medications, use of serum hCG testing when uncertainty exists, optimizing radiation exposure strategies, and clear, informed consent processes outlining fetal risks. Adoption of these best practices may improve clinical consistency and enhance patient safety.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2605-2612"},"PeriodicalIF":2.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The CXCL12/CXCR4 Axis: An Emerging Therapeutic Target for Chronic Pain.","authors":"Zhangwei Chen, Yunfan Xia, Boyi Liu, Jianqiao Fang, Qimiao Hu","doi":"10.2147/JPR.S509541","DOIUrl":"10.2147/JPR.S509541","url":null,"abstract":"<p><p>Chronic pain greatly affects patients' quality of life and poses significant challenges for the healthcare system. Conventional medication is generally inadequate for managing chronic pain and frequently leads to numerous adverse effects. The chemokine C-X-C motif ligand 12 (CXCL12) and its receptor, the chemokine C-X-C motif receptor 4 (CXCR4), are emerging as significant neuromodulators within the nervous system. A growing body of evidence has underscored the critical roles of this chemokine axis in the development and persistence of pathological pain. In this review, we aim to synthesize recent findings that highlight the role and mechanisms of the CXCL12/CXCR4 axis in the etiology of chronic pain conditions. We focus on chronic pain stemming from sciatic nerve injury, diabetic neuropathy, spinal cord injury, bone cancer, opioid tolerance, and opioid-induced hyperalgesia. These conditions represent a diverse range of pathologies that underscore the broad impact of the CXCL12/CXCR4 axis in pain management. Furthermore, we discuss the potential for targeting the CXCL12/CXCR4 axis as a comprehensive therapeutic strategy for chronic pain. In this review, we aim to summarize emerging evidence on the critical role of the CXCL12/CXCR4 signaling in mediating chronic pain pathogenesis and its potential contributions to neurological disorders.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2583-2603"},"PeriodicalIF":2.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Needs and Wishes Towards Sex- and Gender-Sensitive Chronic Pain Management: A Qualitative Study with German General Practitioners.","authors":"Alexandra Piotrowski, Alexandra Schmidt, Natalie Seuken, Lia Goldberg, Neele Kufeld, Christine Kersting, Veronika Bencheva, Petra Thürmann, Achim Mortsiefer","doi":"10.2147/JPR.S522497","DOIUrl":"10.2147/JPR.S522497","url":null,"abstract":"<p><strong>Purpose: </strong>This study is part of the GESCO feasibility project (funded by the German Federal Ministry of Health) aimed at developing a sex- and gender-sensitive primary care intervention for patients with chronic non-cancer pain (CNCP) receiving long-term opioid therapy (LTOT). To inform the intervention design, we explored general practitioners' (GPs) experiences and needs in managing this patient group, with a particular focus on the role of sex and gender.</p><p><strong>Methods: </strong>We conducted semi-structured telephone interviews with five GPs in Germany using a convenience sample. Interviews were transcribed verbatim and analyzed using the Rapid approach to integrate findings quickly into the broader project.</p><p><strong>Results: </strong>Treating patients with CNCP and LTOT is highly complex and emotionally demanding. GPs described feeling caught between patients' high expectations and their own limitations, which often strained therapeutic relationships. Gender dynamics played a key role in shaping these interactions. While male GPs emphasized neutrality, underlying gender stereotypes still influenced their behavior. Female GPs reported stronger trust with female patients, while male GPs described a greater focus on asserting control. Stigmatization-especially affecting female patients-was reported to hinder open communication and trust. GPs expressed the need for more time, better training in gender-sensitive care, and stronger interdisciplinary collaboration.</p><p><strong>Conclusion: </strong>To improve care for patients with CNCP and LTOT, recommendations include: extending consultation times with adequate reimbursement, ensuring comprehensive medical histories, enhancing GP training in gender-sensitive care, improving diagnostic tools, and promoting peer collaboration. Further measures involve supporting patient self-management, empathy, and communication, as well as adopting a biopsychosocial and sex- and gender-sensitive approach to treatment.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2567-2581"},"PeriodicalIF":2.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Repetitive Peripheral Magnetic Stimulation (rPMS) in Relieving Post-Needling Soreness in Patient with Upper Trapezius Myofascial Pain Syndrome: A Double-Blind, Randomized Clinical Trial.","authors":"Anja Vearasilp, Chomkajee Sukareechai","doi":"10.2147/JPR.S519318","DOIUrl":"10.2147/JPR.S519318","url":null,"abstract":"<p><strong>Objective: </strong>To study the effectiveness of relieving post-needling soreness with repetitive peripheral magnetic stimulation (rPMS) compared with sham.</p><p><strong>Methods: </strong>This double-blind, randomized clinical trial evaluated the effects of repetitive peripheral magnetic stimulation (rPMS) on post-needling soreness following dry-needling treatment. Participants who had active myofascial pain trigger points (MTrPs), in the upper trapezius muscle and received dry needling at the upper trapezius muscle were randomly assigned to either an rPMS group, which received targeted magnetic stimulation at the site of post-needling soreness, or a sham group, which receiving a placebo intervention simulating the rPMS procedure. The rPMS parameters were set to standard mode with normal current direction and a biphasic waveform. Specific settings included an inter-pulse interval of 10, burst pulse of 2, pulse B/A ratio of 1.0, a repetitive rate of 20 pulses per second, and a total of 20 pulse trains over a 10-minute session. Results were assessed using a standardized pain scale to quantify soreness levels at various intervals post-treatment, ultimately aiming to determine if rPMS significantly enhances recovery compared to sham stimulation of magnetic stimulation sessions at the sore area or a sham group undergoing a placebo intervention mimicking the rPMS procedure. The primary outcome was the pressure pain threshold (PPT) change, measured immediately after dry needling and post-intervention. Secondary outcomes included changes in pain intensity, assessed using the Numeric Rating Scale (NRS) immediately post-dry needling, post-intervention, and at 24- and 48-hours post-intervention, as well as neck range of motion, measured at the same intervals. This methodology provided a robust framework to compare the therapeutic effects of rPMS with a placebo intervention in managing post-needling soreness.</p><p><strong>Results: </strong>The rPMS group demonstrated a significant increase in PPT compared to the sham group (P=0.002). The Numeric Rating Scale (NRS) also significantly improved in the rPMS group compared to the sham group (P < 0.05). No serious adverse events were reported.</p><p><strong>Conclusion: </strong>Repetitive peripheral magnetic stimulation (rPMS) is an effective method for relieving post-needling soreness compared to sham treatment. This non-invasive modality may benefit clinical practice by enhancing patient comfort and recovery after needling interventions.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2541-2548"},"PeriodicalIF":2.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Acute Pain in Obese Patients Undergoing Atrial Fibrillation Ablation.","authors":"Peiyu Dong, Hongbai Wang, Fuxia Yan, Zhe Zhang","doi":"10.2147/JPR.S517820","DOIUrl":"10.2147/JPR.S517820","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have indicated that obesity can lead to an increased pain sensitivity. However, the risk of acute pain in obese patients undergoing atrial fibrillation (AF) ablation remains unclear.</p><p><strong>Methods: </strong>This was a case-control study. Clinical data of patients with AF who underwent percutaneous ablation at Fuwai Hospital between January and May 2019 were retrospectively collected. Numeric pain rating scale (NPRS) and Body mass index (BMI) were used to assess severity of intra-procedural pain and pre-procedural obesity, respectively. An intra-procedural NPRS score of 4 or higher indicated the presence of acute pain, and a pre-procedural BMI of 28 or greater was considered indicative of obesity. Multivariable logistic regression analysis was performed to explore the risk of intra-procedural acute pain in obese patients.</p><p><strong>Results: </strong>A total of 333 eligible patients were divided into two groups based on presence of intra-procedural acute pain (case group: n=102 [30.6%] and control group: n=231 [69.4%]). Compared with control group, patients with intra-procedural acute pain showed higher percentage of obesity (40 [17.4%] vs 28 [27.5%]) and conscious sedation (96 [41.6%] vs 89 [87.3%]), lower percentage of diabetes history (38 [16.5%] vs 10 [9.8%]), and longer duration of procedure (median, 90 vs 110 min). The occurrence rates of acute pain during AF ablation were 41.2% for obese patients and 27.9% for non-obese patients. Obesity was independently associated with an increased risk of intra-procedural acute pain (adjusted odds ratio [OR], 2.29; 95% CI, 1.18-4.43, P = 0.014). Sub-group analysis indicated a stronger risk of intra-procedural acute pain in obese patients under conscious sedation (adjusted OR, 2.48; 95% CI, 1.13-5.42, P = 0.023).</p><p><strong>Conclusion: </strong>Under conscious sedation, obesity is an independent risk factor for intra-procedural acute pain in adult patients undergoing AF ablation.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2549-2557"},"PeriodicalIF":2.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors for Postoperative Nerve Recovery in Severe Carpal Tunnel Syndrome.","authors":"Zixuan Luo, Tao Ma, Siyu Tian, Kunlun Yu, Dehu Tian","doi":"10.2147/JPR.S519904","DOIUrl":"10.2147/JPR.S519904","url":null,"abstract":"<p><strong>Purpose: </strong>Severe carpal tunnel syndrome (CTS) is a nerve compression disease that can lead to muscle atrophy from denervation. However, research on neurological recovery after surgery in severe CTS patients is relatively limited. This study mainly explores the predictors for poor postoperative neurological recovery in severe CTS patients.</p><p><strong>Methods: </strong>This study collected data of severe CTS patients who received surgery in our hospital from January 2022 to January 2024. According to the recovery of nerve function during follow-up, patients were divided into two groups. Clinical data of severe CTS patients were analyzed.</p><p><strong>Results: </strong>Age (P<0.001), disease duration (P=0.013), and 2-PD (P<0.001) of patients were closely related to poor postoperative neurological recovery at 6-month follow-up. Logistic regression analysis showed that age (P=0.011) and 2-point discrimination (2-PD) (P=0.001) were independent risk factors for poor neurological function recovery at 6 months follow-up and the cutoff values of age and 2-PD were 53 years and 13.5 mm, respectively. Univariate analysis showed that age (P=0.044), disease duration (P=0.015), 2-PD (P<0.001), and grip strength (P=0.005) were closely related to poor postoperative neurological recovery at 12-month follow-up. Logistic regression analysis showed that 2-PD (P=0.034) was a predictor of poor neurological function recovery at 12-month follow-up and the cutoff value of 2-PD was 13.5 mm.</p><p><strong>Conclusion: </strong>We found that age and 2-PD were independent risk factors for poor neurological function recovery at 6-month follow-up. However, 2-PD is a predictor for poor neurological recovery at 1-year follow-up. We also identified their cutoff values. This study helps us to personalize the risk of postoperative neurological recovery in patients with severe CTS in order to provide targeted early intervention.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2559-2565"},"PeriodicalIF":2.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}