Journal of Pain Research最新文献

{"title":"Association Between Aerobic and Muscle-Strengthening Activities and Health-Related Quality of Life in Patients with Neck Pain: The National Health and Nutrition Examination Survey 2001-2004.","authors":"Liangliang Zhang, Bo Zhang, Wenzhang Yuan, Jiefeng Hu, Junying Yuan, Xuejie Wang","doi":"10.2147/JPR.S484798","DOIUrl":"10.2147/JPR.S484798","url":null,"abstract":"<p><strong>Purpose: </strong>Different types of activities have independent and additive benefits for adult health. This study intended to assess the association between aerobic activity and muscle-strengthening activities and health-related quality of life (HRQoL) and physical and mental health in patients with neck pain.</p><p><strong>Methods: </strong>This cross-sectional study included data on patients with neck pain from the National Health and Nutrition Examination Survey (NHANES) dataset between 2001 and 2004. Weighted logistic regression analyses were applied to estimate the odds ratio (OR) and 95% confidence interval (CI) for the associations between aerobic activity, muscle-strengthening activities, and their combination, and HRQoL, physically unhealthy days (≥14 days/month), and mentally unhealthy days (≥14 days/month). Subgroup analyses were performed according to age, gender, and screen time.</p><p><strong>Results: </strong>A total of 794 patients with neck pain were included, of whom 504 had good HRQoL and 290 had poor HRQoL. Aerobic activity (OR=0.35, 95% CI: 0.21-0.57) and muscle-strengthening activities (OR=0.50, 95% CI: 0.26-0.98) were associated with good HRQoL in patients with neck pain, but only aerobic activity (OR=0.42, 95% CI: 0.28-0.63) was linked to shorter physical unhealthy days. No associations were found between aerobic activity, muscle-strengthening activities, and mentally unhealthy days (<i>P</i>>0.05). The trends for the combined result of aerobic activity and muscle-strengthening activities on HRQoL, physically unhealthy days, and mentally unhealthy days were significant (<i>P_trend</i> <0.001). Subgroup analyses found that the combined result of aerobic and muscle-strengthening activities was only more significant on HRQoL in patients aged <60 years or ≥60 years, males or females, and patients with screen time <3 hours or ≥3 hours (<i>P_trend</i> <0.05).</p><p><strong>Conclusion: </strong>Aerobic and muscle-strengthening activities were associated with good prognosis in patients with neck pain, but the effect of aerobic activity may be more pronounced.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3553-3564"},"PeriodicalIF":2.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11537042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture and Moxibustion in the Treatment of Gynecological Perioperative Anxiety: A Systematic Review and Meta-Analysis.","authors":"Xiu Wang, Qianqian Yu, Jun Zhu, Junlan Liu, Xuyuan Gao, Xiudie Wang, Lanlan Wang, Xia Xu","doi":"10.2147/JPR.S464808","DOIUrl":"10.2147/JPR.S464808","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review and meta-analysis aims to investigate the effectiveness and safety of acupuncture and moxibustion in managing perioperative anxiety during gynecological surgery.</p><p><strong>Methods: </strong>Relevant studies published from the establishment of the databases to March 20, 2023, were searched in PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wanfang, VIP, and CBM. Literature screening and data extraction were independently conducted by two investigators. The Cochrane risk-of-bias tool 2.0 was utilized to assess the risk of bias in the included studies. Data analysis was carried out using Stata 15.1 software.</p><p><strong>Results: </strong>The analysis included a total of 3254 patients from twenty studies. It was found that acupuncture and moxibustion therapy resulted in a reduction of postoperative State-Trait Anxiety Inventory (STAI-S) scores (mean difference [MD] = -3.50, 95% confidence interval [CI] [-6.93 to -0.07], P = 0.046), as well as both preoperative and postoperative Visual Analogue Scale-Anxiety (VAS-anxiety) and Self-Rating Anxiety Scale (SAS) scores (pre-operation: SMD = -1.04, 95% CI [-1.73 to -0.35], P = 0.003; post-operation: SMD = -0.78, 95% CI [-1.21 to -0.35], P < 0.001) in comparison to the control group. Nonetheless, no significant variances were noted between the two groups with regards to preoperative and intraoperative STAI-S scores (pre-operation: MD = -3.38, 95% CI [-9.58 to 2.82], P = 0.286; intraoperative: MD = -1.09, 95% CI [-7.32 to 5.13], P = 0.730), and intraoperative VAS-anxiety and SAS scores (SMD = -0.44, 95% CI [-1.51 to 0.64], P = 0.427).</p><p><strong>Conclusion: </strong>During the perioperative period of gynecological surgery, acupuncture and moxibustion therapy show potential in alleviating anxiety in patients. It is noteworthy that the current level of evidence is limited by the small sample size. Therefore, further validation of these findings is necessary.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3515-3538"},"PeriodicalIF":2.5,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11533889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan, a Natural Polymer, is an Excellent Sustained-Release Carrier for Amide Local Anesthetics.","authors":"Yun-Mei Yu, Yuan-Zhu Long, Zhao-Qiong Zhu","doi":"10.2147/JPR.S480926","DOIUrl":"10.2147/JPR.S480926","url":null,"abstract":"<p><p>Local anesthetics, particularly amide types, play a crucial role in perioperative anesthesia to alleviate pain and manage chronic, long-term pain, with their brief effect period remaining a universal challenge that needs resolution. There is a high anticipation for creating materials that maintain prolonged effectiveness of local anesthetics through a straightforward administration technique. Chitosan is the most typical natural amino polymer, which is highly reactive and easy to modify. It has been widely and deeply used in the field of medicine. At present, it is mainly used in tissue regeneration and repair, hemostasis and wound healing, antibacterial and anti-infection, disease diagnosis and treatment detection, and drug delivery. In the field of anesthesia, chitosan is regarded as a potential perfect carrier for the sustained release of amide local anesthetics. This document aims to analyze the current application of chitosan as a prolonged-release substance in amide-type local anesthetics, encapsulate the associated research advancements, and subsequently investigate the practicality and prospects of its medical uses.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3539-3551"},"PeriodicalIF":2.5,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Considerations of Interscalene Brachial Plexus Block in the Treatment of Post-Hepatectomy Shoulder Pain [Response to Letter].","authors":"Yuecheng Yang, Yunkui Zhang, Jun Zhang","doi":"10.2147/JPR.S501927","DOIUrl":"10.2147/JPR.S501927","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3513-3514"},"PeriodicalIF":2.5,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11531274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy, Safety, and Economic Feasibility of Dokhwalgisaeng-Tang for Degenerative Knee Osteoarthritis: Protocol for a Multicenter, Randomized, Assessor Blinded, Controlled Trial.","authors":"Wonnam Kim, Yeon-Cheol Park, Bonhyuk Goo, Jung-Hyun Kim, Dongwoo Nam, Eunseok Kim, Hyun-Jong Lee, Dong-Hyun Pyun, Hae Sun Suh, Yoonsung Lee, Man S Kim, Byung-Kwan Seo, Yong-Hyeon Baek","doi":"10.2147/JPR.S487089","DOIUrl":"10.2147/JPR.S487089","url":null,"abstract":"<p><strong>Purpose: </strong>Knee osteoarthritis (KOA) is one of the most prevalent degenerative joint diseases worldwide. The herbal decoction, Dokhwalgisaeng-tang (DHGST), has been commonly used in East Asia to treat osteoarthritis. However, there is insufficient evidence to draw clear conclusions concerning its effectiveness and safety for patients with KOA. We aim to determine the efficacy, safety, and economic feasibility of DHGST compared with Celecoxib, an oral COX-2 inhibitor, for patients with degenerative KOA.</p><p><strong>Trial design and methods: </strong>This multicenter, randomized, noninferiority trial, involving 160 participants who will be randomized using block randomization with 1:1 allocation, will compare DHGST and Celecoxib. The total trial period is 24 weeks after random allocation, comprising 12 weeks of treatment and 12 weeks of follow-up. Participants with KOA will be administered 200 mg of DHGST (treatment group) or Celecoxib capsules (control group) for 12 weeks. Efficacy and safety evaluations will be conducted at weeks 0, 4, 8, and 12, and 24. The primary outcome measurement is the Korean Western Ontario McMaster score at week 12. Changes in pain intensity using a 100 mm visual analog scale, changes in quality of life using a EuroQol 5-dimension 5-level self-report survey, and patient satisfaction will also be measured to evaluate effectiveness between the two groups. A trial-based economic feasibility evaluation will be conducted to analyze treatment cost-effectiveness from societal and healthcare system perspectives. Drug safety will be assessed through adverse reactions and laboratory test findings.</p><p><strong>Discussion: </strong>This trial protocol has the following limitations. Applying a double-dummy design is not possible, as the tablet and granule forms can easily be distinguished visually, and achieving participant blinding is challenging. The trial findings are intended to inform participants, physicians, and other stakeholders in determining whether DHGST could be used as an alternative therapeutic option for KOA.</p><p><strong>Trial registration number: </strong>KCT0008424 (Clinical Research Information Service of the Republic of Korea), registered on 12 May 2023.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3501-3510"},"PeriodicalIF":2.5,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Commentary on \"Acupuncture and Related Therapies for Endometriosis: A Network Meta-Analysis of Randomised Controlled Trials\" [Letter].","authors":"Yi-Chen Zeng, Kean Zhu, Jianqiao Fang","doi":"10.2147/JPR.S500793","DOIUrl":"10.2147/JPR.S500793","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3511-3512"},"PeriodicalIF":2.5,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D Levels and Temporomandibular Disorders: A Bidirectional Two-Sample Mendelian Randomization Analysis.","authors":"Shiya Zeng, Yanyue Tan, Zhiwei Cao, Yunhao Zheng, Tiqian Liu, Yifei Deng, Xin Xiong","doi":"10.2147/JPR.S489583","DOIUrl":"10.2147/JPR.S489583","url":null,"abstract":"<p><strong>Objective: </strong>Growing researches explore vitamin D's role in temporomandibular disorders (TMDs), but the link between vitamin D and TMDs remains debated. To clarify the causal relationship, we conducted a Mendelian randomization (MR) analysis using data from genome-wide association studies (GWAS).</p><p><strong>Subjects and methods: </strong>The GWAS dataset of vitamin D (GWAS ID: ukb-d-30890_irnt; sample size: 329247) was obtained from the IEU Open GWAS project. And that of TMDs (GWAS ID: finn-b-TEMPORO; sample size: 134280), initiated on August 25th, 2017 and publicly released on December 18th, 2023, was extracted from the FinnGen dataset, whose cases were diagnosed based on the revised International Classification of Diseases, 10th Edition (ICD-10) code K07.6. Both datasets were obtained from the European population. According to three assumptions of MR analysis, a bi-directional MR analysis was performed to measure the causal relationship, with Inverse variance weighted (IVW) as the primary method and MR Egger and Weighted median as supplement. Moreover, diverse sensitivity analyses, including Cochran's Q test, MR Egger intercept, Mendelian randomized polymorphism RESidual Sum and Outlier (MR-PRESSO), and leave-one-out analysis, were used to verify the stability of the findings.</p><p><strong>Results: </strong>The MR analysis supported causal effects of vitamin D levels on TMDs risks within the European population using IVW method [odds ratio = 1.316; 95% confidence interval = 1.086 to 1.595; P = 0.005], supported by MR Egger and Weighted median. While there was no indication that TMDs have a direct impact on vitamin D levels [β: -0.00738, standard error = 0.00665; P = 0.568].</p><p><strong>Conclusion: </strong>The study revealed that within the European population higher levels of vitamin D led to higher risks of developing temporomandibular disorders, but found no obvious evidence that TMDs are causally associated with vitamin D. The conclusion should be cautiously interpreted, given the selection bias of TMDs patients sample.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3487-3500"},"PeriodicalIF":2.5,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Transverse Ultrasound-Guided Approach for Puncturing the Cervical Dorsal Root Ganglion at the Level of Articular Pillar for Radiofrequency Treatment.","authors":"Jinyu Lai, Yijun Wu, Yong Xiang, Yun Wang","doi":"10.2147/JPR.S479986","DOIUrl":"10.2147/JPR.S479986","url":null,"abstract":"<p><strong>Purpose: </strong>Currently, minimally invasive intervention surgery for cervical spondylotic radiculopathy mostly involves the use of cervical dorsal root ganglion (DRG) block or radiofrequency modulation therapy. Here, we proposed a novel transverse ultrasound-guided approach for puncturing the cervical dorsal root ganglion at the level of joint column for radiofrequency treatment.</p><p><strong>Patients and methods: </strong>A retrospective analysis of the clinical data of 30 patients with cervical spondylotic radiculopathy admitted to the Pain Department of Taihe Hospital Affiliated with Hubei Medical University from January 2021 to March 2024 was performed. During surgery, motor electrical stimulation was used to induce movement in the nerve-innervated area, and the relationship between the puncture needle tip and the cervical DRG position was verified using a C-arm X-ray machine. The numerical rating scale (NRS) was used for preoperative and postoperative pain assessment, clinical treatment effectiveness was evaluated, surgical duration and the associated complications were also recorded.</p><p><strong>Results: </strong>Thirty patients exhibited clear cervical DRG images under ultrasound guidance, and the punctures were successful in all patients. Motor electrical stimulation induced movement in the corresponding nerve innervation area in the range of 0.3-0.8 mv in all patients. No serious complications occurred during the procedure.</p><p><strong>Conclusion: </strong>The transverse ultrasound-guided approach for puncturing the cervical dorsal root ganglion at the level of joint column for radiofrequency treatment is effective, convenient, and safe.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3473-3485"},"PeriodicalIF":2.5,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11517412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-Amputation Pain: Combined Analyses of Randomized Controlled Trials Evaluating Opioids and Gabapentinoids versus Placebo.","authors":"Adam Arthur, Leonardo Kapural, Richard P Chiacchierini, Nicholas J Hargus, William R Patterson","doi":"10.2147/JPR.S486220","DOIUrl":"10.2147/JPR.S486220","url":null,"abstract":"<p><strong>Background: </strong>An estimated 185,000 patients per year undergo an extremity amputation in the United States (over 500 amputations/day). Prolonged postoperative opioid use, defined as the presence of a filled opioid prescription between 90 and 180 days following the operative amputation procedure, affects nearly 50% of amputees. Moreover, the use of preoperative benzodiazepines, muscle relaxants, anticonvulsants, and antidepressants is strongly linked to prolonged opioid use suggesting new therapeutic strategies are needed. The goal of this study was to better understand how well post-amputation pain is currently treated by selected pharmacologic agents and the success rates of these existing agents.</p><p><strong>Methods: </strong>The available literature on PubMed was screened for articles that used randomized-controlled trial (RCT) study designs and gabapentinoids (eg, gabapentin or pregabalin) or opioids (eg, morphine). Two morphine-related RCTs using at least 50% pain reduction responder criteria were combined and qualitatively compared with two gabapentin trials that were previously combined to understand the potential benefits of these drugs in post-amputation pain management compared with placebo.</p><p><strong>Results: </strong>All 4 trials included measured post-amputation pain over a 4- to 6-week acute period. The combined opioid analysis demonstrated a treatment effect that favored morphine (<i>P</i>=0.02) over placebo and indicated the number needed to treat (NNT) of 3.9 (95% CI: 2.5, 9.3) patients. Similarly, the previously combined analysis of gabapentin trials favored gabapentin over placebo and indicated an estimated NNT of 8.9 (95% CI: 5.3, 27.8).</p><p><strong>Conclusion: </strong>Patients undergoing limb amputation have a clear unmet need for more adequate chronic pain control. Given that post-amputation pain is often diagnosed as a chronic condition, persisting for at least 90 days, our data highlight the need for larger sample sizes and longer-term controlled trials to better understand the advantages and disadvantages of chronic use of gabapentinoids and opioids/opioid combination drugs in this patient population.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3449-3453"},"PeriodicalIF":2.5,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Exercise Rehabilitation for Degenerative Tibial Meniscal Tears: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Sujie Mao, Kaiwen Xiao, Hong Xu, YanAn Wang, Xiujin Guo","doi":"10.2147/JPR.S467423","DOIUrl":"10.2147/JPR.S467423","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to comprehensively evaluate the effectiveness of exercise rehabilitation therapy for patients with Degenerative Meniscal Lesions of the Tibia (DMLT), providing more effective and safer treatment options for DMLT patients and offering more reliable evidence-based medical recommendations.</p><p><strong>Methods: </strong>Adhering to the PRISMA guidelines, this research conducted a literature search through databases such as PubMed, Web of Science, EMBASE, EBSCOhost, and Cochrane, with the search cut-off date being January 2024. Following the PICOS principles, a comprehensive search was conducted. Two researchers independently screened the literature and extracted data. Using R software, effect size analyses were conducted on indicators such as pain, knee joint function, lower limb muscle strength, and physical function in DMLT patients, with the significance level set at P<0.05, aiming to comprehensively assess the impact of exercise therapy on the rehabilitation outcomes for DMLT patients.</p><p><strong>Results: </strong>The study included 12 randomized controlled trials, encompassing 1336 DMLT patients. Based on the quality assessment using the modified Jadad scale, the overall quality of the included studies was determined to be moderate.The meta-analysis showed that exercise therapy significantly reduced pain (WMD=-5.50, P<0.05), improved lower limb muscle strength (SMD=0.05, P<0.05), and enhanced physical function (SMD=0.65, P<0.05). Subgroup analyses revealed that, compared to surgery alone, exercise therapy combined with surgery had a significant effect on improving muscle strength and physical function. Functional training and home-based exercises showed more pronounced effects on specific indicators. The study results indicate that exercise therapy alone has limited effectiveness in improving knee joint function, and combining exercise with surgery does not show a significant advantage (P > 0.05). Additionally, subgroup analysis revealed no significant impact of intervention duration, exercise type, or patient age on functional improvement.</p><p><strong>Conclusion: </strong>Exercise therapy has shown potential in alleviating pain, enhancing lower limb muscle strength, and improving mobility in patients with degenerative meniscal lesions of the tibia (DMLT). Functional training and varied rehabilitation exercises may provide effective pathways for long-term recovery in these patients.</p><p><strong>Registration: </strong>This study has been registered in a prospective registry platform with the registration number: CRD42024518643.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"3431-3448"},"PeriodicalIF":2.5,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}