Journal of Pain Research最新文献

{"title":"Suzetrigine: Is This What We Have Been Waiting for or Just the Beginning?","authors":"Christopher L Robinson, Michael E Schatman, Jamal Hasoon, Matthew Chung, Trent Emerick, Giuliano Lo Bianco, Sait Ashina, R Jason Yong","doi":"10.2147/JPR.S527710","DOIUrl":"https://doi.org/10.2147/JPR.S527710","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2047-2049"},"PeriodicalIF":2.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of Key Brain Regions Involved in Acupuncture and Moxibustion Analgesia: An Imaging-Based Study.","authors":"Liuxuan He, Ruizhu Zhou, Shuai Hou, Dan Huang, Xiaoxiao Zhao, Miaomiao Wang, Mengying Huang, Tao Yin, Haiyan Yin, Shuguang Yu","doi":"10.2147/JPR.S505312","DOIUrl":"https://doi.org/10.2147/JPR.S505312","url":null,"abstract":"<p><strong>Background: </strong>Acupuncture and moxibustion, as traditional therapies in Chinese medicine, are widely recognized for their therapeutic effects, particularly in pain relief. Nevertheless, the exact mechanisms underlying their analgesic effects remain to be fully elucidated. Advancements in neuroimaging techniques have opened a novel pathway for investigating alterations in brain function resulting from acupuncture and moxibustion analgesia.</p><p><strong>Purpose: </strong>The purpose of this study was to investigate the brain regions activated during acupuncture and moxibustion treatment for pathological pain using neuroimaging, to better understand the underlying analgesic mechanisms.</p><p><strong>Patients and methods: </strong>An electronic search of PubMed was conducted using the keywords \"acupuncture\", \"moxibustion\", \"analgesia\", and \"neuroimaging\". A total of 37 articles, focusing on 14 diseases, were identified and analyzed.</p><p><strong>Results: </strong>Acupuncture primarily activated regions in the frontal, parietal, and temporal lobes, with key areas including the anterior cingulate cortex (ACC), insula, prefrontal cortex (PFC), and primary somatosensory cortex (S1). Different stimulation modes and disease types produced distinct patterns of brain region activation.</p><p><strong>Conclusion: </strong>Acupuncture and moxibustion modulate key brain regions involved in pain perception, emotional regulation, and cognitive functions. Acupuncture predominantly affects the sensory cortex, enhancing pain perception, while moxibustion has a more pronounced effect on the limbic system and thalamus, influencing emotional and cognitive aspects of pain. The findings indicate that acupuncture and moxibustion serve as effective non-pharmacological therapies for pain management, offering valuable insights into their underlying analgesic mechanisms. Future research should focus on further elucidating these mechanisms and optimizing clinical applications.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2051-2067"},"PeriodicalIF":2.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manual Therapy for Cervical Radiculopathy: Effects on Neck Disability and Pain - A Systematic Review and Network Meta-Analysis.","authors":"Xueliang Xu, Yan Ling","doi":"10.2147/JPR.S513428","DOIUrl":"https://doi.org/10.2147/JPR.S513428","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the application effects of different manual therapy approaches in the treatment of cervical radiculopathy using a network meta-analysis.</p><p><strong>Methods: </strong>Prospective randomized controlled trials on manual therapy for cervical radiculopathy published in PubMed, the Cochrane Library, and Embase databases were retrieved. The neck disability index and visual analogue scale for neck pain were collected and subjected to network meta-analysis.</p><p><strong>Results: </strong>A total of 8 eligible studies involving 632 participants with a mean age range of 40-47 years were included. The intervention duration ranged from 4 to 6 weeks. Three intervention groups were defined: Group C (exercise and other therapies without manual therapy), Group M (manual therapy without traction), and Group MT (manual therapy with traction). Larger circles indicate more patients, and thicker lines show more studies comparing interventions. Group M had the highest probability (68.1%) of improving the neck disability index, followed by Group MT (29.1%), with Group C the lowest (2.8%). Compared to Group C, neck disability index scores improved by 0.58 (95% CI: -0.17, 1.33) in Group M and by 0.36 (95% CI: -0.39, 1.11) in Group MT. The difference between Group M and Group MT was not significant (0.22, 95% CI: -0.59, 1.03). For neck pain (visual analogue scale score), Group M had the highest probability (59.5%) of improvement, followed by Group MT (39.6%), with Group C the lowest (0.9%). Compared to Group C, the visual analogue scale score improved by 0.74 (95% CI: -0.04, 1.52) in Group M and by 0.61 (95% CI: -0.18, 1.40) in Group MT. The difference between Group M and Group MT was not significant (0.13, 95% CI: -0.72, 0.98). Egger's regression test showed no apparent publication bias.</p><p><strong>Conclusion: </strong>Manual therapy is an effective approach for improving neck pain and neck disability index in patients with cervical radiculopathy, but more evidence-based support is needed regarding the use of cervical traction.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2035-2045"},"PeriodicalIF":2.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Impact of a Low-Carbohydrate Diet on The Chronic Pain Experience Among Adults with an Acquired Limb Loss: A Pilot Study.","authors":"Asia M Wiggins, Paige M Benlolo, Sunil V Suresh, Nathaniel M Goldfeiz, Conley J Carr, Robert E Sorge","doi":"10.2147/JPR.S507742","DOIUrl":"https://doi.org/10.2147/JPR.S507742","url":null,"abstract":"<p><strong>Purpose: </strong>Acquired limb loss can be a traumatic experience that is often accompanied by chronic pain (ie, phantom limb pain (PLP) and/or residual limb pain (RLP)) and can cause a reduction in emotional well-being and overall quality of life. Although, there are available treatments for PLP/RLP, few provide long-term relief. Therefore, the purpose of this study was to investigate the potential benefits of diet on reported pain and quality of life measures among adults with acquired limb loss.</p><p><strong>Methods: </strong>Seven adults with acquired limb loss (M = 50.57, SD ± 13.63 years of age) were enrolled in a 6-week low-carbohydrate diet (LCD) intervention. Baseline, 3-week, and 6-week measures of pain sensitivity (BPI, NPQ), cognitive flexibility (CFS), depression (CES-D, PROMIS-57), anxiety (PROMIS-57), pain resilience (PRS), and overall quality of life (SF-36) were obtained using validated questionnaires.</p><p><strong>Results: </strong>On average, all participants had appreciable levels of depression (M = 18.71, SD ± 6.16) and anxiety (M = 19.71, SD ± 5.94), yet relatively high levels of pain resilience (M = 44.42, SD ± 6.70) at baseline. After 6 weeks, participants showed improvements in self-reported measures of pain severity, emotional well-being, and other psychosocial measures of interest, including depression and anxiety.</p><p><strong>Conclusion: </strong>These results suggest that an LCD might have an influence on multiple chronic pain-related factors among adults living with an amputation. Furthermore, adults living with chronic PLP/RLP may report high resilience, although high levels of depression and anxiety are also reported.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2025-2034"},"PeriodicalIF":2.5,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupotomy Ameliorates KOA Related Chondrocyte Premature Senescence Through YAP/FOXD1 Pathway.","authors":"Yunxuan Ma, Tingyao Hu, Naigang Liu, Changqing Guo, Longfei Xing, Weiwei Ma, Yongqi Cui, Xilin Chen","doi":"10.2147/JPR.S475829","DOIUrl":"https://doi.org/10.2147/JPR.S475829","url":null,"abstract":"<p><strong>Purpose: </strong>Premature senescence of chondrocytes is a typical lesion of knee osteoarthritis (KOA). Abnormal cartilage stress can inhibit the mechanosensitive Yes-associated protein (YAP) / transcription factor forkhead box D1 (FOXD1) pathway, which is related to premature senescence of chondrocytes, thereby accelerating the progression of the lesion. This study aims to investigate whether acupotomy intervention could inhibit the premature senescence of chondrocytes and protect the cartilage of KOA rabbits.</p><p><strong>Methods: </strong>18 male New Zealand rabbits were randomly divided into 3 groups (n = 6 each): control, KOA, and KOA + acupotomy (KOA+Apo). KOA, KOA+Apo rabbits were modeled by modified Videman's method for 6 weeks. After modeling, the KOA+Apo groups were subjected to acupotomy once a week for 3 weeks on the muscles around the left hind knee. The modified Lequesne MG score and passive range of motion (PROM) were used to evaluate the general condition and exercise ability of rabbits. Cartilage degeneration was detected by safranin O-fast green staining and transmission electron microscope(TEM). Type II collagen (Col-II) and aggrecan by immunohistochemistry (IHC), IL-7 and MMP-13 by Enzyme-Linked Immunosorbent Assay (ELISA), and p53, Rb1, p - YAP, YAP, FOXD1 by IHC, Western blot, or RT - PCR.</p><p><strong>Results: </strong>Acupotomy effectively curbed cartilage degeneration and chondrocyte premature senescence in KOA rabbits. Mechanistically, it cut IL - 7 and MMP-13 levels, easing the inflammatory milieu and extracellular matrix degradation. It also regulated p53 and Rb1, controlling cell - cycle progression. Crucially, acupotomy upregulated the YAP/FOXD1 pathway, which, by affecting downstream genes, modulated IL - 7, MMP-13, p53, and Rb1 levels, acting as a pivotal molecular link in its regulatory effects.</p><p><strong>Conclusion: </strong>Acupotomy may protect KOA rabbits' cartilage by inhibiting chondrocytes premature senescence via the YAP/FOXD1 pathway, offering a new theoretical basis for treating mechanically - induced KOA.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2011-2023"},"PeriodicalIF":2.5,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicidal Ideation and Self-Injury in Trigeminal Neuralgia.","authors":"Nathan S Fishbein, Jafar Bakhshaie, Jonathan Greenberg","doi":"10.2147/JPR.S493649","DOIUrl":"https://doi.org/10.2147/JPR.S493649","url":null,"abstract":"<p><strong>Purpose: </strong>Trigeminal neuralgia is commonly associated with emotional distress and unique challenges that may increase the risk of suicidality. Nevertheless, suicidality remains understudied in this population. This study reports rates and severity of suicidal ideation and self-injury and the association between suicidality, emotional distress, and pain intensity in a large sample of adults with trigeminal neuralgia and related neuralgias.</p><p><strong>Patients and methods: </strong>We recruited 229 adults with trigeminal neuralgia and other related conditions to complete a cross-sectional survey assessing suicidal ideation, self-injury, and emotional distress. We analyzed rates and severity of suicidal ideation and self-injury. We performed independent samples <i>t</i>-tests to compare the severity of suicidality between respondents with high and low levels of anxiety, depression, and pain intensity.</p><p><strong>Results: </strong>Over a third (34.6%) of respondents reported at least some thoughts of suicide in the past 2 weeks, 27.6% reported thinking the world would be better off without them, 57.7% reported thinking about their own death, 14.0% reported thinking about hurting themselves, 2.6% reported hurting themselves purposefully, and 1.3% reported cutting or burning themselves. Over a third of respondents (39.1%) had elevated anxiety, and suicidality was more severe among those with elevated anxiety than among those without (n = 214, p < 0.001). Over a quarter of respondents (28.5%) had elevated depression, and suicidality was more severe among those with elevated depression than among those without (n = 213, p < 0.001). Almost two-thirds of respondents (62.9%) had elevated pain intensity, and suicidality was more severe among those with elevated pain intensity than among those without (n = 228, p < 0.001).</p><p><strong>Conclusion: </strong>Suicidality is an urgent yet under-addressed concern among adults with trigeminal neuralgia and is associated with high rates of anxiety, depression, and pain intensity in this population. We propose recommendations to enhance suicide screening and develop interventions to reduce suicide risk among those with chronic orofacial pain.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2003-2010"},"PeriodicalIF":2.5,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explicit Motor Imaging Abilities Are Similar in Complex Regional Pain Syndrome, Chronic Limb Pain and Healthy Individuals: A Cross-Sectional Study.","authors":"Gabriel Cohen-Aknine, Denis Mottet, Alexis F Homs, Thibault Mura, François Jedryka, Arnaud François Dupeyron","doi":"10.2147/JPR.S494546","DOIUrl":"https://doi.org/10.2147/JPR.S494546","url":null,"abstract":"<p><strong>Background: </strong>Complex regional pain syndrome (CRPS) is a chronic pain condition characterized by peripheral, central sensory and motor dysfunction. Implicit motor imagery is known to be impaired in CRPS patients, but evidence for explicit motor imagery is still lacking. Using a self-rated questionnaire, this study aims to compare explicit motor imagery abilities between individuals with CRPS, with chronic limb pain (CLP), and healthy controls, and to also examine differences between affected and unaffected limbs. We hypothesize that both CRPS and CLP patients will show a decrease in motor imagery abilities compared to healthy controls and in their affected limb compared to their own contralateral, unaffected side.</p><p><strong>Patients and methods: </strong>In this single-center observational study, 123 participants were recruited (CRPS = 40, chronic limb pain, CLP = 40, and healthy individuals = 43). Participants completed the Movement Imagery Questionnaire-Revised Second (MIQ-RS) once for each side of the body. The total MIQ<i>-RS</i> score, and the kinesthetic and visual subscores were compared between groups and between the affected and unaffected sides.</p><p><strong>Results: </strong>A high degree of heterogeneity was observed in the explicit motor imagery scores and subscores, regardless of whether the participants were healthy or individuals with chronic pain. The MIQ<i>-RS</i> did not reveal any significant differences in explicit motor imagery abilities, neither between groups nor between the affected and unaffected side. Bayesian testing of the null hypothesis for kinesthetic motor imagery abilities indicated a sevenfold likelihood of no differences between groups and a more than a fivefold likelihood of no differences between sides.</p><p><strong>Conclusion: </strong>Individuals with CRPS and chronic limb pain displayed preserved explicit motor imagery abilities, notably on the pain side. The preservation of these abilities supports the recommendation of mental imagery therapy to improve motor function and relieve pain in chronic pain patients.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1949-1961"},"PeriodicalIF":2.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Psychosocial Factors and Response to Epidural Steroid Injection for Chronic Lumbosacral Radicular Pain: A Prospective Pilot Study.","authors":"Meredith Stensland, Elizabeth Sanford, Timothy T Houle, Cindy McGeary, Briana A Cobos, Selena Lugosi, Luke Lehman, Paul S Nabity, Caleigh Covell, Elizabeth Fitzgerald, Mahsa Mojallal, David E Reed, Sanjog Pangarkar, Blessen C Eapen, Udai Nanda, Zachary L McCormick, Donald McGeary","doi":"10.2147/JPR.S496290","DOIUrl":"https://doi.org/10.2147/JPR.S496290","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic lumbosacral radicular pain is a disabling condition commonly treated with epidural steroid injections (ESIs). Extant research suggests that psychosocial factors impact clinical outcomes among patients with back pain. The purpose of this study is to examine the relationship between psychosocial variables and post-injection pain intensity.</p><p><strong>Setting: </strong>Interventional pain management clinic.</p><p><strong>Methods: </strong>A prospective longitudinal cohort study with repeated within-subject measures. Assessment timepoints included a pre-injection baseline, immediately post-injection, 6 weeks, and 12 weeks, and 6 months; patients completed a battery of self-report assessments at each point. The primary outcome was pain intensity (numeric rating scale 0-10). Data were analyzed using principal component analysis and generalized linear mixed-effects modeling.</p><p><strong>Results: </strong>A total of 40 patients (age 52 ±13.05) participated in this study. Higher pre-injection pain was predictive of higher post-injection pain at all time points (<i>p</i><0.001). Controlling for baseline pain and demographics, those with Negative Affect 1 standard deviation higher at baseline reported a 1.12-point mean higher pain rating at 12 weeks than those with lower Negative Affect (95% CI: 0.18-2.07; p=0.020), while those with <i>Cognitive Resilience</i> 1 standard deviation higher at baseline had a 1.12-point mean lower pain rating at 6 months post-injection (95% CI: -2.09 -0.05, p=0.040).</p><p><strong>Conclusion: </strong>Patients with higher negative affect and lower cognitive resilience achieve less pain improvement after ESIs for low back pain. Future research with a larger sample should focus on deepening our understanding of the role of psychosocial functioning as a potential mechanism of treatment response in patients undergoing ESI procedures. Findings point to the importance of multidisciplinary chronic pain care.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1991-2002"},"PeriodicalIF":2.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shallow Acupuncture for Chronic Neck Pain: A Multicenter Randomized Controlled Trial Protocol with fMRI and DTI.","authors":"Jiahui Lin, Zhilin Gu, Peng Zhou, Weikang Huang, Aihua Ou, Qi Zhao, Zhenhua Xu","doi":"10.2147/JPR.S512989","DOIUrl":"https://doi.org/10.2147/JPR.S512989","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to explore the central mechanisms of shallow acupuncture for chronic neck pain (CNP) using functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), an innovative approach not commonly applied in shallow acupuncture research.</p><p><strong>Patients and methods: </strong>This multi-center randomized controlled trial will recruit 252 CNP patients from three centers (84 per center). Participants will be randomly assigned to three groups: shallow acupuncture, drug control (celecoxib capsules), or waiting list group, with 84 patients per group. The primary outcomes include total effective rate, visual analogue scale (VAS), Neck Disability Index (NDI), and brain imaging results (20 randomly selected patients per group). Secondary outcomes include the Self-Rating Anxiety Scale (SAS), Short Form 36 Questionnaire (SF-36), and cervical range of motion (CROM). Data will be collected at baseline, after 2 weeks, and at 3-month follow-up. fMRI and DTI data will be collected at baseline and after 2 weeks. Analyses will include regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), functional connectivity (FC), fractional anisotropy (FA), and mean diffusivity (MD) within and between groups. An additional 20 healthy volunteers will provide baseline fMRI and DTI data for comparison.</p><p><strong>Conclusion: </strong>This study will validate the clinical efficacy of shallow acupuncture for CNP and explore its central mechanisms using fMRI and DTI. The findings may provide neuroimaging evidence supporting the broader clinical application of shallow acupuncture in treating CNS-related diseases.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1963-1973"},"PeriodicalIF":2.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease Burden of Neck Pain in China from 1990 to 2021 and Its Prediction for 2042: The Global Burden of Disease Study 2021.","authors":"Jiaming Wei, Kexin Yang, Jiarui Xue, MingYi Luo, Wei Peng, Xunlu Yin, Wu Sun, Chunyu Gao, Guangfei Teng, He Yin, Minshan Feng, Luguang Li, Kai Sun, Wei Zhang","doi":"10.2147/JPR.S516118","DOIUrl":"https://doi.org/10.2147/JPR.S516118","url":null,"abstract":"<p><strong>Purpose: </strong>This study, aimed to report the rates and trends of the prevalence, incidence, and years lived with disability caused by neck pain in the general population of China from 1990 to 2021 and forecast the incidence, prevalence, and disability-adjusted life Years (DALYs) from 2022 to 2042.</p><p><strong>Methods: </strong>We used data from the Global Burden of Diseases Study (GBD) 2021. The annual percentage change (APC) and average APC between 1990 and 2021 were calculated using joinpoint regression analysis. An autoregressive integrated moving average (ARIMA) model was used to forecast the incidence, prevalence, and DALYs rates between 2022 and 2042.</p><p><strong>Results: </strong>From 1990 to 2021, the disease burden of neck pain in China showed a clear upward trend, with age-standardised incidence rate (ASIR), age-standardised prevalence rate (ASPR), and DALYs rates being significantly higher in females than in males. Especially in terms of DALYs, Aging has had the largest impact, contributing 61.88% of the increase, while population growth has accounted for 32.43%. Joinpoint regression analysis showed that the incidence and prevalence of neck pain in China increased gradually from 2000 to 2021. Data from 2021 showed that individuals aged 45-59 years are the most affected by neck pain, regardless of sex. The prediction results of the ARIMA model indicate that China's ASIR and ASPR for neck pain are projected to continue increasing over the next 20 years.</p><p><strong>Conclusion: </strong>Neck pain is a serious public health problem in the general Chinese population. This may be related to changes in people's lifestyles and work patterns due to improvements in societal well-being and technology. Raising awareness of the risk factors for neck pain in the general population could help reduce the future burden of neck disorders, and neck pain should be a priority for future research on prevention and therapy.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1975-1990"},"PeriodicalIF":2.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}