Journal of Pain Research最新文献

{"title":"A Commentary on Acupoints for Headache with Blood Stasis Syndrome: A Literature Study Based on Data Mining Technology [Letter].","authors":"Yaling Zheng, Yujun He, Yi Xu","doi":"10.2147/JPR.S536187","DOIUrl":"10.2147/JPR.S536187","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2373-2374"},"PeriodicalIF":2.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12071737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality or Quantity? The Quiet Influence of Industry-Sponsored Centers of Excellence.","authors":"Scott G Pritzlaff, Victoria Flower, Vafi Salmasi, Samir J Sheth, Michael E Schatman","doi":"10.2147/JPR.S538431","DOIUrl":"https://doi.org/10.2147/JPR.S538431","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2375-2377"},"PeriodicalIF":2.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Need for Urgent Action and Reform: Is the Veterans Administration's Pain Care Under Fire?","authors":"Krishnan Chakravarthy, Michael E Schatman","doi":"10.2147/JPR.S533050","DOIUrl":"https://doi.org/10.2147/JPR.S533050","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2359-2360"},"PeriodicalIF":2.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serious Adverse Drug Reactions to Long-Term Oral Liquid Morphine in Patients with Chronic Pain: A Cross-Sectional Survey in Palliative Care.","authors":"Barbara Duncan, Germanus Natuhwera, Doris Nassuuna, Roselight Katusabe, Hanif Kasozi, Wilson Acuda","doi":"10.2147/JPR.S515028","DOIUrl":"https://doi.org/10.2147/JPR.S515028","url":null,"abstract":"<p><strong>Background: </strong>Behaviour suggestive of addiction in some patients on long-term oral liquid morphine (OLM) caused concern amongst the Hospice Africa Uganda clinical team and prompted the survey. This survey aimed to identify serious adverse drug reactions to long-term OLM in patients with chronic pain receiving palliative care.</p><p><strong>Methods: </strong>In Phase 1, the database of patients receiving palliative care at Hospice Africa Uganda was analyzed to find patients taking OLM from 12.7.2017 to 19.10.2017. A purposive review of their medical records was undertaken to identify those on long-term OLM. Phase 2 was conducted between 12.6.2018 and 23.10.2018. All patients on long-term OLM were offered biopsychosocial and spiritual assessment by a pain specialist (BD) to determine whether they were experiencing any serious adverse drug reactions. Phase 3 immediately followed phase 2 assessment. The pain specialist discussed with the participant any medication changes (including OLM) or other therapies to facilitate holistic management of pain for the individual.</p><p><strong>Results: </strong>In phase 1, 653 patients on OLM were identified. Phase 2 identified 49 patients who were on long-term OLM. Thirty-four patients agreed to participate in the assessment with the pain specialist. Of the 34 participants, 24 had chronic non-cancer pain and two had chronic cancer pain. Eight cancer survivors had incidental chronic non-cancer pain. Serious adverse drug reactions were identified in four participants with chronic non-cancer pain. Two cases of addiction, one case of opioid hyperalgesia, and one probable diversion of morphine.</p><p><strong>Conclusion: </strong>To our knowledge, the study identified the first documented cases of addiction to OLM in sub-Saharan Africa. Future research involving a larger multicenter sample, longitudinal, and qualitative designs is needed. Education of healthcare practitioners prescribing opioids should put equal emphasis on management of chronic non-cancer pain as do chronic cancer pain to minimize the risk of serious adverse reactions.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2361-2371"},"PeriodicalIF":2.5,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multisite Chronic Pain and the Risk of Breast Cancer and Its Subtypes: A Mendelian Randomization Study.","authors":"Wanyu Li, Jintao Liu, Teng Wang, Yudong Hou, Jianheng Bao, Yanyan Song, Longbi Liu, Shuke Ge, Yaohua Shang, Rongdi Wang, Min Zhang, Meng Xu","doi":"10.2147/JPR.S489703","DOIUrl":"https://doi.org/10.2147/JPR.S489703","url":null,"abstract":"<p><strong>Background: </strong>Chronic pain (CP) is widespread and a major cause of disability. However, its genetic and environmental risk factors, as well as its relationship with breast cancer (BC), remain unclear. The study is the first to apply Mendelian randomization (MR) to explore the causal relationship between CP and BC.</p><p><strong>Methods: </strong>Two-sample MR and multivariable MR (MVMR) were performed using genome-wide association study (GWAS) data. Univariable MR assessed the effect of CP on BC, while MVMR adjusted for body mass index (BMI). The inverse variance-weighted method was used as the primary method.</p><p><strong>Results: </strong>Univariable MR found a strong genetic link between stomach/abdominal pain and overall BC risk (OR 3.411, 95% CI 1.029-11.313, P=0.045). Neck/shoulder pain was associated with Luminal_A breast cancer risk (OR 1.999, 95% CI 1.263-3.163, P=0.003). Multivariable MR, adjusting for BMI, confirmed these findings for stomach/abdominal pain to overall BC (OR 4.39, 95% CI 1.48-13.06, P=0.008) and neck/shoulder pain to Luminal_A BC (OR 2.46, 95% CI 1.24-4.87, P=0.010). No associations were found for other pain types (headache, hip pain, back pain, knee pain, facial pain) with BC subtypes.</p><p><strong>Conclusion: </strong>Genetic evidence in this study suggests a causal link between stomach/abdominal pain and overall BC, and between neck/shoulder pain and Luminal-A BC risk in Europeans. Determining the cause of this discrepancy might shed light on the complicated link between breast cancer etiology and chronic pain genetics, emphasizing the need for further investigations and potential clinical applications to enhance breast cancer prevention and management.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2343-2357"},"PeriodicalIF":2.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analyzing Trends in the Pain Fellowship Match - A Survey of Program Directors.","authors":"Jeremy Jueng, Scott G Pritzlaff, Neel Mehta, Amitabh Gulati, Michael E Schatman, Sayed Emal Wahezi, Miles Day, Shravani Durbhakula, Daniel J Pak","doi":"10.2147/JPR.S496104","DOIUrl":"https://doi.org/10.2147/JPR.S496104","url":null,"abstract":"<p><strong>Introduction: </strong>Based on recent data, the pain fellowship match is decreasing in competitiveness. The most recent 2023-2024 match cycle had the most unfilled positions and the highest match rate in the last five years. Although there has been some speculation about potential factors contributing to these trends, our study aimed to gather insight from pain fellowship program directors (PDs) nationwide to provide valuable perspectives on recent match trends.</p><p><strong>Methods: </strong>We created an anonymous online survey, with questions regarding potential factors contributing to match trends over the last five years. Our survey was emailed to 115 program directors (PDs), and one follow-up Email was sent three weeks later to maximize responses.</p><p><strong>Results: </strong>Surveys were completed by 25.2% (29/115) of PDs. Over the past five years, 82.8% of PDs (24/29) reported a decrease in applications to their program. For residency specialty of pain fellowship applicants, 100% of PDs (29/29) reported a decline in anesthesiology applicants. Most PDs reported an increase in applicants from PM&R (62.1%, 18/29), Neurology (69.0%, 20/29), and Emergency Medicine (93.1%, 27/29). For potential contributors to these trends, increasing compensation in primary residency specialty was the most significant perceived contributor, with a weighted average of 4.89/5. Decreasing pain reimbursement was the second strongest contributor, with a weighted average of 4.31/5.</p><p><strong>Conclusion: </strong>Increasing compensation in primary residency specialty and declining pain reimbursements were the two most significant perceived contributors to the recent decline in interest in pain fellowship to resident trainees. Pain medicine is now attracting a more diverse applicant pool with a decrease in anesthesiology applicants and an increase in PM&R, Internal Medicine, Neurology, Emergency Medicine, and Psychiatry applicants. Future pain fellows' increased variety of training backgrounds may present an opportunity to critically assess the current pain medicine curriculum to suit the needs of a more diverse cohort.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2335-2341"},"PeriodicalIF":2.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12067977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Sore Throat After Tracheal Intubation: An Updated Narrative Review and Call for Action.","authors":"Zheping Chen, Zhenxiang Zuo, Le Zhang, Moxuan Gong, Yuyang Ye, Yanwu Jin, Xin Zhao","doi":"10.2147/JPR.S498933","DOIUrl":"https://doi.org/10.2147/JPR.S498933","url":null,"abstract":"<p><strong>Background: </strong>Postoperative sore throat (POST) represents a common airway complication closely related to endotracheal tube (ETT), exhibiting a higher incidence following tracheal intubation compared to other airway apparatuses. Nevertheless, considering its mild and self-limiting character, POST is often overlooked. This study provides an updated narrative review on the latest perspectives regarding POST, including a comprehensive summary of its mechanisms, risk factors, clinical assessment methods, prevention and treatment strategies. Additionally, directions for future research are proposed.</p><p><strong>Methods: </strong>A comprehensive search was conducted using keywords such as \"postoperative sore throat\" and \"tracheal intubation\" in PubMed, Web of Science, and Cochrane databases from their inception to October 2024. Two groups of reviewers independently performed data search and cleaning after standard training. To address gaps in knowledge or potential biases, the literature was thoroughly screened based on established criteria, and a comprehensive synthesis, analysis, and summary of the relevant findings was conducted.</p><p><strong>Results: </strong>The precise cause of POST remains unknown, and its potential mechanism is believed to involve secondary inflammation triggered by irritation, mechanical trauma, tracheal intubation, and cuff inflation. The risk factors for POST encompass preoperative, intraoperative, and postoperative factors. Currently, effective prevention methods for POST consist of pharmacological interventions, non-pharmacological interventions, and traditional Chinese medicine (TCM) therapy. In terms of pharmacological interventions, non-steroidal anti-inflammatory drugs (NSAIDs) and steroid can effectively prevent the occurrence of POST through their anti-inflammatory properties. However, given the unavoidable side effects of medications, non-pharmacological interventions and non-invasive methods may offer greater benefits for POST and related hoarseness. For example, proficient and gentle intubation techniques can prevent mechanical injury caused by repeated intubation attempts. Currently, several studies have demonstrated the potential role of TCM in managing POST. Nonetheless, the precise mechanisms underlying its effects remain to be elucidated, and the available clinical evidence is still limited.</p><p><strong>Conclusion: </strong>Given that POST is prevalent following tracheal intubation but frequently overlooked, we advocate heightened awareness of its occurrence and progression, and recommend integrating the prevention and management of POST into routine clinical practice.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2285-2306"},"PeriodicalIF":2.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-Analysis of Randomized Controlled Trials for Electroacupuncture Treatment of Migraine.","authors":"ShiWei Song, Hao Chen","doi":"10.2147/JPR.S518294","DOIUrl":"https://doi.org/10.2147/JPR.S518294","url":null,"abstract":"<p><strong>Purpose: </strong>Numerous clinical studies have shown that patients with migraine can benefit from electroacupuncture treatment. However, there are no published systematic reviews and meta-analyses of pure electroacupuncture for migraine. Therefore, we conducted a meta-analysis to evaluate the efficacy of pure electroacupuncture as a standalone treatment for migraine patients.</p><p><strong>Patients and methods: </strong>We searched Six electronic databases. All from the inception to August 1st, 2024. In the literature, clinical investigators evaluated the efficacy and safety of electroacupuncture as the primary treatment for migraine. Researchers assessed the quality of the studies using the Cochrane Handbook for Systematic Reviews of Interventions. The Review Manager 5.4 software was used to perform statistical analysis.</p><p><strong>Results: </strong>Ten randomized controlled trials involving 1161 people were included. The meta-analysis yielded a substantial result: the application of pure electroacupuncture significantly improved the effective rate compared to the control group. In the visual analogue scale score, the present study found no significant difference between electroacupuncture and Western medicine as standalone treatments. Regarding migraine-associated symptom scores, the experimental group exhibited no superiority in comparison to the control group. Moreover, following the intervention, several significant changes were observed in the secondary outcome indicators between the two groups, including cerebral arterial blood flow velocity, the migraine attack days, the lasting time of headache remission, mean time of the headache attack, duration of the headache attack, and the migraine-specific quality of life questionnaire score, with the results proving to be statistically significant.</p><p><strong>Conclusion: </strong>The results of the analysis suggested that pure electroacupuncture is beneficial for migraine patients, but it remains difficult to obtain comprehensive data. Our study is supported by evidence of low to moderate quality. It is necessary to further confirm the efficacy of pure electroacupuncture for migraine with higher-quality clinical research.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2321-2333"},"PeriodicalIF":2.5,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized, Sham-Controlled Trial on the Efficacy and Safety of Electroacupuncture for Lumbar Disc Herniation with Radiculopathy: Rationale and Study Protocol.","authors":"Yuwei Yang, Liting Liu, Lixia Yuan, Xiaoya Liu, Haoying Ding, Xu Zhou, Qianan Cao","doi":"10.2147/JPR.S512711","DOIUrl":"https://doi.org/10.2147/JPR.S512711","url":null,"abstract":"<p><strong>Introduction: </strong>Electroacupuncture, validated in preclinical studies, is a promising alternative approach for lumbar disc herniation with radiculopathy (LDHR). This trial aims to evaluate the efficacy and safety of electroacupuncture in patients with LDHR.</p><p><strong>Methods: </strong>This randomized, single-blind, sham-controlled trial will enroll 170 participants diagnosed with LDHR and who present Numerical Rating Scale (NRS) scores ≥4 for both lower back and leg pain. Participants will be allocated at a 1:1 ratio to receive either electroacupuncture or sham electroacupuncture (superficial needling at nonacupoint sites). The sample size was determined based on pilot study data and power calculations. Treatments will be administered three times weekly over 8 weeks (24 sessions total), with blinding maintained throughout. An 18-week noninterventional follow-up will be extended to address the knowledge gap regarding the durability of neuromodulatory effects of electroacupuncture. The following outcomes will be evaluated: 1) primary outcome: the proportion of responders achieving ≥ a 2-point NRS reduction in both lower back and leg pain from baseline at weeks 8 and 24; 2) secondary outcomes: changes from baseline at weeks 4, 8, 16, and 24 in the intensity of low back pain and leg pain, level of disability, severity of depression and anxiety, sleep quality, as well as the incidence of lumbar spine surgery and the proportion of use of analgesics at weeks 8 and 24; and 3) safety outcome: the incidence of adverse events. The efficacy outcomes will be analyzed based on the full analysis set with the modified intention-to-treat principle. Treatment effects will be estimated using a generalized linear mixed-effects model for repeated measures. Blinding validity will be assessed via James's and Bang's indices.</p><p><strong>Conclusion: </strong>This rigorously designed randomized controlled trial will generate confirmatory evidence to support the efficacy and safety of electroacupuncture in the treatment of LDHR.</p><p><strong>Trial registration no: </strong>NCT06611332 (https://clinicaltrials.gov/study/NCT06611332).</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2307-2319"},"PeriodicalIF":2.5,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation Factors Mediate Association of Muscle Mass and Migraine: NHANES 1999-2004 and Mendelian Randomization.","authors":"Chunyan Jia, Hong Li, Shaonan Yang, Yue Liu, Lijun Liu, Aijun Ma, Liang Zhang","doi":"10.2147/JPR.S516748","DOIUrl":"https://doi.org/10.2147/JPR.S516748","url":null,"abstract":"<p><strong>Purpose: </strong>The relationship between adipose-muscle distribution and its effect on migraine remains unclear. This study examines the association between muscle mass and migraine prevalence and evaluates potential mediation by systemic inflammatory biomarkers.</p><p><strong>Methods: </strong>Using a cross-sectional design, we analyzed data from 10,400 participants in the National Health and Nutrition Examination Survey (NHANES) (1999-2004). The association between appendicular lean mass normalized to body mass index (ALM/BMI) and migraine prevalence was evaluated through weighted logistic regression and subgroup analyses. Mediation analyses were conducted to examine the potential mediating roles of inflammatory markers, including C-reactive protein (CRP), white blood cell count (WBC), and neutrophils, in the relationship between ALM/BMI and migraine prevalence. Genetic causality was investigated via two-sample Mendelian randomization (MR) using genome-wide association study (GWAS) data.</p><p><strong>Results: </strong>20% of total participants reported migraines. A higher ALM/BMI ratio was inversely associated with migraine after full adjustment (OR = 0.243; 95% CI: 0.122-0.487, <i>p</i> < 0.001). Vigorous activity reduced migraine susceptibility by 24% (OR = 0.760; 95% CI: 0.663-0.872, <i>p</i> < 0.001). CRP, WBC and neutrophils mediated 2.0% (<i>p</i> = 0.024), 3.1% (<i>p</i> = 0.011), and 2.8% (<i>p</i> = 0.019) of the ALM/BMI-migraine association, respectively. The inverse-variance weighted approach (IVW) in MR analysis indicated that higher basal metabolic rate (BMR) reduced migraine risk (OR = 0.996, 95% CI: 0.992-0.998, <i>p</i> = 0.004) and headache risk (OR = 0.998, 95% CI: 0.997-1.000, <i>p</i> = 0.018). Fat-free mass also exhibited protective effects on migraines (OR = 0.997, 95% CI: 0.994-1.000, <i>p</i> = 0.045).</p><p><strong>Conclusion: </strong>Increased muscle mass is associated with reduced migraine risk, partially mediated by attenuating systemic inflammation. These findings provide us with an approach of health management to prevent migraines.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2269-2283"},"PeriodicalIF":2.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}