Journal of Pain Research最新文献

{"title":"Comparison of the Effects of 20 W and 40 W Electrocautery Power on Postoperative Pain Following Internal Thoracic Artery Harvesting in Coronary Bypass Surgery.","authors":"Güler Gülsen Ersoy","doi":"10.2147/JPR.S533349","DOIUrl":"https://doi.org/10.2147/JPR.S533349","url":null,"abstract":"<p><strong>Purpose: </strong>After coronary artery bypass graft surgery (CABG), patients may experience pain and numbness in the anterior chest wall. These symptoms can negatively impact patients' quality of life and overall cardiac surgery satisfaction. This study investigates the effect of monopolar electrocautery output power, for hemostasis in the remaining internal thoracic wall after harvesting of the Internal Thoracic Artery (ITA), on postoperative pain in the anterior chest wall.</p><p><strong>Patients and methods: </strong>This paper examined 100 patients who had ITA harvesting during CABG in a Cardiovascular Surgery Clinic. Patients who were able to comply with postoperative pain tests and had sufficient mental and visual capacity were included in the study. In Group 1 (n: 50) patient, after the ITA was harvested, hemostasis was performed with 20 watt cautery power on the inner wall of the thorax. In Group 2 (n: 50) patients, hemostasis was performed with 40 watt electrocautery power. It was investigated whether there was a difference between these two groups in terms of postoperative drainage amounts and pain in the anterior chest wall with Behavioral Pain Scale (BPS) and Visual Analogue Scale (VAS).</p><p><strong>Results: </strong>No statistically significant difference between Group 1 and Group 2 regarding demographic data and postoperative drainage amounts. However, in Group 1, in patients who hemostasis performed in the inner wall of the thorax with a low cautery power of 20 watts, postoperative pain was statistically significantly lower than in Group 2 in terms of BPS and VAS.</p><p><strong>Conclusion: </strong>After harvesting of the ITA, hemostasis of the thoracic wall with 20 watt low cautery power does not affect the postoperative drainage. Additionally, these patients experience less postoperative pain due to less thermal damage after CABG. Furthermore, lower postoperative pain levels may reduce treatment costs by reducing analgesic requirements and intensive care duration.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3543-3550"},"PeriodicalIF":2.5,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12266055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally Invasive Lumbar Decompression (MILD) in Patients with Lumbar Spinal Stenosis: A Systematic Review of Randomized and Prospective Trials.","authors":"Vwaire Orhurhu, Scott Brancolini, Danielle Zheng, Sean Snyder, David S Jevotovsky, Harman Chopra, Sidharth Sahni, Nathan Li, Ryan S D'Souza, Maria Evankovich, Brendan Lynch, Michael Edward Farrell, Benedict J Alter, Trent Emerick","doi":"10.2147/JPR.S521038","DOIUrl":"https://doi.org/10.2147/JPR.S521038","url":null,"abstract":"<p><strong>Background/importance: </strong>Lumbar spinal stenosis (LSS) remains one of the most common causes of pain and functional disability in patients with chronic pain. Minimally invasive lumbar decompression (MILD) has been shown to reduce pain and improve function with lumbar spinal stenosis. However, very few large studies have evaluated the short- and long-term effects of MILD on functional improvement and pain reduction.</p><p><strong>Purpose: </strong>To evaluate the evidence on the MILD procedure for chronic pain patients with LSS.</p><p><strong>Methods: </strong>A systematic review of randomized and prospective trials investigating the effectiveness of the MILD procedure in managing low back pain and lower extremity pain was performed using PubMed, Medline, Embase, Google Scholar, clinical trial.gov, and Cochrane. We utilized the Cochrane review methodologic quality assessment, GRADE and Interventional Pain Management Techniques - Quality Appraisal of Reliability and Risk of Bias Assessment (IPM-QRB) and IPM-QRB for Nonrandomized Studies (IPM-QRBNR) to guide our data extraction and assessment of study quality methods. Our study summarized and presented the evidence quality on a scale of 1 to 5.</p><p><strong>Results: </strong>Fifteen MILD studies met our inclusion criteria. There were 8 studies that were multicenter prospective trials, and 7 studies were single centers prospective trials. The evidence based on a systematic review of prospective trials investigating the efficacy of the MILD procedure showed a median level 2b evidence with several level 1b studies available. Pain and functional outcome GRADE assessment of studies was high quality.</p><p><strong>Conclusion: </strong>This systematic review suggests that the MILD procedure can be effective in managing chronic pain patients with lumbar spinal stenosis.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3527-3540"},"PeriodicalIF":2.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of CT-Guided Pulsed Radiofrequency of the Dorsal Root Ganglion Combined with Methylene Blue Sympathetic Injection on Herpes-Zoster Neuralgia: A Retrospective Study.","authors":"Jie Chen, Jiajia Deng, Ruxiang Wang, Ling Ma","doi":"10.2147/JPR.S516413","DOIUrl":"https://doi.org/10.2147/JPR.S516413","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the efficacy of Computed Tomography (CT) Guided Pulsed Radiofrequency (PRF) of the Dorsal Root Ganglion (DRG) combined with Methylene Blue (MB) sympathetic injection in acute herpes zoster neuralgia.</p><p><strong>Background: </strong>MB is a nitric oxide synthesis inhibitor that has been reported to exert analgesic and anti-inflammatory properties. In this study, MB was injected to the thoracic or lumbar sympathetic nerve to inhibit sympathetic nerve conduction or destroy nerve endings. This is the first report for thoracic or lumbar sympathetic nerve MB injection.</p><p><strong>Materials and methods: </strong>64 patients in study were divided into two groups: PRF combined with sympathetic nerves MB injection group (group A; n = 32,); PRF group (group B; n = 32). The therapeutic effects of each group were compared using the Numeric Rating Scale (NRS) scores and the average doses of Pregabalin (mg/d) immediately after surgery (T1) and at one month (T2), three months (T3), six months (T4), nine months (T5), and twelve months (T6) post-operation. The incidence of postherpetic neuralgia (PHN) and complications in the two groups were observed and enrolled.</p><p><strong>Results: </strong>No significant differences in general conditions between the two groups. Compared with the preoperative baseline scores (T0), the NRS at T1 to T6 were significantly decreased in both groups. NRS was lower at T1 to T6 in the group A compared with the same times points in group B (P< 0.05). The incidences of PHN in group A were significantly lower at T3 to T6 compared with group B. The daily doses of pregabalin was lower in the A group than B group at T1 to T5, and it was not significantly different at T6 between the two groups. Finally, no adverse complications were recorded in both groups.</p><p><strong>Conclusion: </strong>CT-Guided PRF Combined with MB sympathetic Injection in the treatment of HZ neuralgia is safe and effective, reducing PHN.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3551-3564"},"PeriodicalIF":2.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the Application Rules and Clinical Significance of Acupoints in Acupuncture Treatment of Migraine Based on Data Mining [Response to Letter].","authors":"Yujun He, Yachao Wu, Xiaojun Li","doi":"10.2147/JPR.S551020","DOIUrl":"10.2147/JPR.S551020","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3541-3542"},"PeriodicalIF":2.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pocket Fills for Intrathecal Pump Delivery Systems: A Narrative Review.","authors":"Dylan W Banks, David S Jevotovsky, Whitman Oehlermarx, Mustafa Broachwala, Amitabh Gulati, Krishnan Chakravarthy","doi":"10.2147/JPR.S520502","DOIUrl":"10.2147/JPR.S520502","url":null,"abstract":"<p><p>Intrathecal drug delivery systems (IDDS) are an increasingly common treatment option in the management of refractory chronic pain. IDDS allow for highly customizable administration of medication directly into the intrathecal space, optimizing therapeutic benefit while minimizing systemic side effects. Understanding potential complications of IDDS is key for patient safety. This narrative review examines pocket fills, a potential complication that occurs when inadvertently missing the port on the intrathecal pump reservoir during a pump refill, resulting in the injection of the medication into the surrounding subcutaneous tissue. It is suspected that pocket fill events are vastly underreported and understudied despite posing serious risk for patient safety. Given the limited existing research discussing pocket fills, this narrative review will provide an overview of pocket fills including the anatomy of the intrathecal pump placement, risk factors for pocket fills, preventative techniques, as well as post pocket fill recommendations. Key preventative techniques highlighted include the application of firm pressure throughout the procedure, imaging guidance, as well as post procedure monitoring and device interrogation. As there is a lack of clinical guidelines for pocket fill prevention, we advise tailoring these strategies to available resources and individual patient needs. As IDDS utilization continues to evolve in clinical practice, future quality improvement initiatives could focus on the development of standardized refill protocols, simulation-based training courses and competency assessments, while future research initiatives could focus on comparative analyses of pump refill complication rates under imaging guidance in comparison to template guidance, as well as early detection monitoring technology.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3519-3526"},"PeriodicalIF":2.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis and 15-Year Projections of the Global Burden of Tension-Type Headache by Sex from 1990 to 2021: A Systematic Review of GBD 2021 Data.","authors":"Hongli Xu, Xiaoyan Qin, Guoli Zhao, Zeguo Feng, Shaohua You","doi":"10.2147/JPR.S512335","DOIUrl":"https://doi.org/10.2147/JPR.S512335","url":null,"abstract":"<p><strong>Background: </strong>Tension-type headache (TTH) is a prevalent primary headache disorder significantly impacting quality of life and healthcare resource utilization, with females typically bearing a higher disease burden. However, comprehensive analyses and predictive studies on the global TTH burden stratified by gender are currently lacking.</p><p><strong>Aim: </strong>This study utilized data from the Global Burden of Disease (GBD) Study to analyze the global burden of tension - type headache by sex from 1990 to 2021 and conducted a 15 - year projection (up to 2036).</p><p><strong>Methods: </strong>We conducted a systematic review of GBD 2021 data, employing Joinpoint regression analysis and decomposition analysis to assess TTH incidence, prevalence, YLDs, and DALYs. Additionally, we used the ARIMA model for a 15-year predictive analysis of TTH burden trends.</p><p><strong>Results: </strong>From 1990 to 2021, global female TTH cases rose from 669.54 million (95% UI: 586.2-751.8 million) to 1.04 billion (95% UI: 923.0-1.1 billion), with incidence increasing from 242.9 million (95% UI: 218.8-267.0 million) to 369.86 million (95% UI: 332.5-407.2 million). Male cases grew from 616.82 million (95% UI: 537.2-696.4 million) to 970 million (95% UI: 851.0-1.0 billion). Decomposition analysis indicated population growth was the primary driver of the increase in female TTH prevalence. Projections suggest that by 2036, the incidence will reach 9,174.84 per 100,000 females (95% UI: 8,854.8-9,494.9), prevalence will be 25,135.1 per 100,000 females (95% UI: 23,977.2-26,283.0), YLD rate will be 62.76 per 100,000 females (95% UI: 58.8-66.7), and DALY rate will be 60.97 per 100,000 females (95% UI: 56.7-65.2).</p><p><strong>Conclusion: </strong>This study highlights the significance of gender in TTH burden, particularly the heightened risk for females. Through temporal trend analysis and predictive modeling, we provide insights into future TTH disease trajectories, aiding global public health policy formulation and healthcare resource allocation.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3505-3517"},"PeriodicalIF":2.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Bushen Jiedu Tongluo Decoction in Active Rheumatoid Arthritis: Study Protocol for a Multi-Center, Randomized, Double-Blind, Controlled Trial.","authors":"Yikun He, Jiaying Shen, Huihui Wu, Lan Chen, Qian Zhou, Qi Wang, Yafang Guo, Fan Wu, Xin Pan","doi":"10.2147/JPR.S512681","DOIUrl":"10.2147/JPR.S512681","url":null,"abstract":"<p><strong>Introduction: </strong>Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease with the primary clinical symptoms of joint swelling and pain. Among the currently available therapeutic agents, methotrexate (MTX) is an internationally recognized first-line disease-modifying antirheumatic drug (DMARD) for RA and is widely used as a basic drug in combination therapies. The Bushen Jiedu Tongluo Decoction (BSJDTL), an herbal formula, has been used for the treatment of RA for more than ten years with a better curative effect. Therefore, we designed a multi-center, randomized, double-blind, placebo-controlled study, to scientifically evaluate the clinical efficacy and safety of BSJDTL for active RA.</p><p><strong>Methods: </strong>This was a multi-center, randomized, double-blind placebo-controlled trial. A total of 120 adult participants with active RA will be enrolled, with a balanced treatment allocation (1:1). The treatment intervention will be BSJDTL plus the conventional medicine methotrexate, and the control intervention will be placebo plus the conventional drug methotrexate for 24 weeks. In addition, both groups received folic acid during treatment to prevent side effects of methotrexate. The primary outcome was DAS28-ESR. Secondary outcomes included changes in joint symptoms and signs, ESR, CRP, MIF, MMP2, CD147, ICAM-1, VCAM-1, and HIF-1α levels, and joint evaluation via musculoskeletal ultrasound and X-ray.</p><p><strong>Discussion: </strong>We designed this multi-center, randomized, double-blind, placebo-controlled clinical trial, utilizing assessment of RA activity and imaging techniques (musculoskeletal ultrasound and X-ray) to scientifically evaluate the clinical efficacy and safety of BSJDTL for active RA. The results of this trial may provide insights into improving the clinical symptoms of patients with RA. We hope that this trial will provide preliminary evidence of the efficacy of BSJDTL in treating RA patients and that these results will aid researchers, practitioners, and patients alike.</p><p><strong>Aim: </strong>This study aimed to clarify the efficacy and safety of BSJDTL in patients with active RA.</p><p><strong>Trial registration: </strong>International Traditional Medicine Clinical Trial Registry, ITMCTR2025000194.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3477-3491"},"PeriodicalIF":2.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Opioid Use and Emergency Department Visits for Spine-Related Disorders.","authors":"Chijioke Okeke, Godwin Okoye, J Douglas Thornton","doi":"10.2147/JPR.S519382","DOIUrl":"10.2147/JPR.S519382","url":null,"abstract":"<p><strong>Background: </strong>Opioids are frequently prescribed to patients with spine-related disorders (SRD), including those undergoing spinal surgery and those with various back or neck pain. Previous studies assessing the association between opioid use and the risk of emergency department (ED) visits among SRD patients have been limited to specific patient subgroups. Using nationally representative sample, we estimated the association between opioid use and the frequency of all-cause ED visits among SRD patients in the United States.</p><p><strong>Methods: </strong>This was a retrospective cross-sectional study design that utilized 2018-2022 Medical Expenditure Panel Survey (MEPS) data. Patients with SRD were identified using ICD-10-CM codes matching for spine-related diagnoses. The primary exposure variable was opioid use, defined by the MEPS prescription drug file. The outcome was all-cause ED visits, which were measured as the number of ED visits observed between 2018 and 2022 as reported in the MEPS emergency room visits files. Descriptive weighted analyses were used to examine the characteristics of patients with SRD. We selected the zero-inflated negative binomial model, which had the best model fit based on the Akaike Information Criterion (AIC), to estimate the incident rate ratio of all-cause ED visits for opioid users compared to non-opioid users.</p><p><strong>Results: </strong>The final sample consisted of 8078 adult patients (18632323 weighted sample) with SRD diagnoses, among whom approximately 21% received opioid prescriptions. The proportion of opioid users compared to non-opioid users varied by gender (opioid users: male 39.34%, female 60.66%; non-opioid users: male 42.45%, female 57.55%; P = 0.045) and insurance type (opioid users: private 61.51%, public 36.92%, uninsured 1.57%; non-opioid users: private 69.87%, public 26.49%, uninsured 3.64%; P < 0.001). Multivariable analysis revealed a significant association between opioid use and increased ED visits (IRR= 1.63, 95% CI: 1.39-1.90).</p><p><strong>Conclusion: </strong>We found that opioid use significantly increases the frequency of all-cause ED visits among SRD patients. These findings highlight the importance of cautious opioid prescribing among SRD patients.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3493-3504"},"PeriodicalIF":2.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Causality Between Bone Mineral Density and Cervical Spondylosis: Bidirectional and Multivariable Mendelian Randomization Study.","authors":"Wangnan Mao, Lianguo Wu","doi":"10.2147/JPR.S516682","DOIUrl":"10.2147/JPR.S516682","url":null,"abstract":"<p><strong>Background: </strong>Recent evidence has suggested a potential link between bone mineral density (BMD) and cervical spondylosis (CS), while the specific relationship has yet to be comprehensively elucidated. Our study aimed to implement a comprehensive analytical framework incorporating bidirectional two-sample Mendelian randomization (MR) and multivariable MR (MVMR) to investigate the causal relationship between BMD and CS.</p><p><strong>Methods: </strong>Genome-wide association summary statistics for BMDs across four skeletal sites and five age groups, and CS, were obtained from public databases. Single Nucleotide Polymorphisms (SNPs) that had a significant genetic association with exposures were used as instrumental variables (IVs). We employed inverse variance weighting (IVW) analysis as the primary analytical method to estimate potential causal effects, whereas Weighted median, MR-Egger regression, weighted mode, and simple mode were served as supplements. Furthermore, several sensitivity analyses (MR-Egger intercept, MR-PRESSO, Cochran's Q test, and Leave-one-out test) were utilized to assess the robustness, heterogeneity, and horizontal pleiotropy of the findings.</p><p><strong>Results: </strong>After applying the Bonferroni correction, BMDs in three skeletal sites exhibited significant positive causal associations with CS risk, including total body (TB), femoral neck (FN), and heel bone (HB). Notably, based on MR analyses of TB-BMD data stratified by five age brackets, the positive causal relationship was especially pronounced in the 45-60-year-old group. Further MVMR analysis revealed that, even after controlling for confounding factors, higher TB-BMD (OR = 1.14, 95% CI: 1.01-1.29; P = 3.12E-02) and HB-BMD (OR = 1.11, 95% CI: 1.01-1.22; P = 2.45E-02) still maintained an independent and significant causal association with CS. However, we did not find evidence to suggest that CS has an impact on BMD in reverse MR analysis.</p><p><strong>Conclusion: </strong>This study provides genetic support for a causal relationship between BMD and CS susceptibility. Specifically, individuals with high BMD are at greater risk of developing CS, offering valuable insights for future clinical research.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3463-3476"},"PeriodicalIF":2.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Bidirectional Mendelian Randomization Study of Causal Relationships Between Migraine and White-Matter Structural Connectivity.","authors":"Dan Tong, Xinyue Zhang, Zhiyong Xiao, Supattra Taothong, Prapawee Teeravarunyou, Wanxia Wu, Sai Wu, Nuo Chen, Siyuan Tao, Jun Zhou, Qian Song, Fanrong Liang, Zhengjie Li","doi":"10.2147/JPR.S521100","DOIUrl":"10.2147/JPR.S521100","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the potential causal relationship between migraine and white matter (WM) structural connectivity using genetic data and the Mendelian randomization (MR) analyses method.</p><p><strong>Methods: </strong>Genome-wide association study (GWAS) summary statistics for migraine (48,975 cases/540,381 controls) and 206 WM structural connectivity related imaging-derived phenotypes (IDPs) (26,333 samples) were collected. Based on instrumental variables (IVs) selected from the GWAS summary statistics, the bidirectional two-sample MR analyses were conducted to infer bidirectional causal associations between migraine and WM structural connectivity. The inverse variance-weighted (IVW) method served as the primary approach for analyzing causality.</p><p><strong>Results: </strong>In the forward MR analysis, it was found that migraine had a significant effect on right hemisphere somatomotor network to amygdala WM structural connectivity (IVW-derived <i>β</i> = 0.11, 95% CI = [0.04, 0.17], <i>p</i> = 1.02e-03, FDR <i>p</i> = 0.04). While in the reverse MR analysis, no causal link was detected between WM structural connectivity and migraine.</p><p><strong>Conclusion: </strong>This study provides genetic evidences for a causal relationship between migraine and WM structural connectivity. These findings provide new perspectives for the understanding of neuropathology and symptomatology in migraine and might provide a potential therapeutic target for future migraine treatment research.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3429-3438"},"PeriodicalIF":2.5,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}