Journal of Pain Research最新文献

{"title":"Herpes Zoster in Pregnancy: Clinical Outcomes and Treatment Patterns from a Multicenter Retrospective Cohort.","authors":"Hongli Xu, Xiaoyan Qin, Zeguo Feng, Shaohua You","doi":"10.2147/JPR.S518448","DOIUrl":"https://doi.org/10.2147/JPR.S518448","url":null,"abstract":"<p><strong>Background: </strong>Herpes zoster is a global health issue that can lead to complications like neuropathic pain and is particularly risky for those with weakened immune systems. Pregnant women, who experience natural immunosuppression, may face more severe symptoms or longer recovery. However, there is limited data on how herpes zoster affects pregnant women and their babies, especially in Asian populations.</p><p><strong>Aim: </strong>This multicenter study evaluates herpes zoster outcomes and treatment patterns in Chinese pregnant women.</p><p><strong>Methods: </strong>This retrospective multicenter study analyzed real-world data from the Big Data Center at PLA General Hospital, examining medical records of pregnant women with herpes zoster from January 1, 2010, to June 30, 2024, across four hospitals. We gathered patient demographics, herpes zoster details, and pregnancy and delivery information, followed by descriptive statistical analysis.</p><p><strong>Results: </strong>In this study, 72 pregnant women with herpes zoster were identified, all of whom completed delivery. The average age of the participants was 31.4 ± 4.7 years. Nearly all (98.6%) experienced neuropathic pain. Seven women took oral acyclovir, two used Radix isatidis, and 37 did not receive medication. Ultimately, 38 women had vaginal deliveries, and 34 underwent cesarean sections. No adverse outcomes related to herpes zoster itself or its treatment were observed in either the mothers or their infants.</p><p><strong>Conclusion: </strong>Herpes zoster during pregnancy showed benign maternal-fetal outcomes regardless of antiviral use, supporting cautious management in this population.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1817-1826"},"PeriodicalIF":2.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11977636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Educational Attainment and Chronic Pain: A Mediation Mendelian Randomization Study.","authors":"Hanqi Wang, Mingjuan Liu, Hongbo Li, Shijie Xu","doi":"10.2147/JPR.S515921","DOIUrl":"10.2147/JPR.S515921","url":null,"abstract":"<p><strong>Background: </strong>The underlying association between educational attainment (EA) and chronic pain (CP) risk is not clear. This study aimed to investigate the causal relationship of EA with CP using Mendelian randomization (MR).</p><p><strong>Methods: </strong>Single nucleotide polymorphisms (SNPs) for EA were selected from the Social Science Genetic Association Consortium (SSGAC). Inverse-variance weighted (IVW), weighted median, penalized weighted median, maximum likelihood (ML), and MR-Egger methods were used to estimate causal effects. Two sample MR analyses were undertaken to assess whether EA has a causal effect on CP. We also performed mediation analyses to estimate the mediation effects.</p><p><strong>Results: </strong>A genetically predicted higher EA was associated with a decreased risk of multisite chronic pain (MCP) (odds ratio [OR] = 0.772, 95% confidence interval [CI] 0.732-0.816 per one standard deviation of longer education, P < 0.05), and the Genome-wide association studies (GWAS) data for chronic widespread pain (CWP) supported the result mentioned above. Potential mediators included body mass index (BMI) (OR = 1.176, 95% CI 1.091-1.267, P < 0.05), smoking (OR = 1.054, 95% CI 1.028-1.081, P < 0.05), and depression (OR = 1.201, 95% CI 1.147-1.258, P < 0.05) have all been proven to be causally associated with MCP. The proportions of the effects of genetically predicted EA mediated through genetically predicted BMI, smoking, and depression were 17.1%, 23.6%, and 9.2%, respectively.</p><p><strong>Conclusion: </strong>Genetically predicted higher educational attainment reduces multisite chronic pain risk, partially mediated by body mass index (17.1%), smoking (23.6%), and depression (9.2%), highlighting education's protective role and its potential in chronic pain prevention strategies.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1793-1804"},"PeriodicalIF":2.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Pharmacovigilance Analysis of Adverse Events Associated with Liposomal Bupivacaine and Bupivacaine.","authors":"Dong Xu Chen, Xuan Ming Chen, Shou Ming Chen, Yi Da Wang","doi":"10.2147/JPR.S519504","DOIUrl":"10.2147/JPR.S519504","url":null,"abstract":"<p><strong>Purpose: </strong>Liposomal bupivacaine, a novel formulation of bupivacaine, is increasingly employed for the long-lasting pain relief. The primary goal of this study was to conduct a thorough safety evaluation of liposomal bupivacaine and bupivacaine.</p><p><strong>Patients and methods: </strong>This study analyzed adverse events (AEs) associated with liposomal bupivacaine and bupivacaine using the FDA Adverse Event Reporting System (FAERS) database from Q1 2004 to Q2 2024. Reports were screened for signal detection, focusing on the onset time and disproportionality analysis to identify positive safety signals. We evaluated the AEs associated with liposomal bupivacaine and bupivacaine. Then, we further categorized them according to the Important Medical Event Terms List (IME list).</p><p><strong>Results: </strong>The analysis revealed 8,023 AE reports in total. Liposomal bupivacaine had 58 positive safety signals, 24 of which were off-label and listed in the IME list. These signals were primarily associated with cardiac (eg, cardiogenic shock), gastrointestinal (eg, paralytic ileus), and neurological disorders. Bupivacaine generated 107 safety signals, with 49 being off-label but also on the IME list. These signals mainly affected the fetus (eg, fetal bradycardia), respiratory system (eg, respiratory depression), and nervous system (eg, neurotoxicity).</p><p><strong>Conclusion: </strong>This study identified unexpected AEs associated with liposomal bupivacaine and bupivacaine. Physicians must exercise particular caution when administering liposomal bupivacaine due to its associated risks. Monitoring for delayed analgesia-related AEs may enhance the safe use of this medication for pain management.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1805-1816"},"PeriodicalIF":2.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five-Step Knee Adjustment Manipulation Based on the 'Muscle and Bone Balance' Principle for Treating Knee Osteoarthritis: Study Protocol for a Randomized Controlled Trial.","authors":"Weiwei Da, Shuang Liu, Qing Qian, Baocai Zhu, Lin Chen, Fan Xue, Pan Sun, Chunchun Xue, Yongpeng Xue, Jiafan Yang, Wenlan Du, Chao Ding, Qi Shi, Xiaofeng Li","doi":"10.2147/JPR.S502187","DOIUrl":"10.2147/JPR.S502187","url":null,"abstract":"<p><strong>Background: </strong>Knee osteoarthritis (KOA) is the leading cause of knee joint dysfunction. Manual therapy (MT) can decrease patients' levels of pain and improve their functionality. But most traditional methods focus solely on the knee joint or its surrounding tissues, neglecting the impact of the waist, hip, ankle, and lower limb alignment on KOA. The objective is to clarify the effects of the five-step knee adjustment manipulation on KOA, evaluate its efficacy, and explore new treatment approaches for manual KOA therapy.</p><p><strong>Methods: </strong>(1) 45 healthy volunteers will be recruited to observe the differences in lower limb alignment, quadriceps cross-sectional area, knee joint range of motion (ROM), and gait between healthy individuals and KOA participants. (2) Conduct a multi-center, randomized, single-blind, controlled clinical trial. 120 eligible participants will be included and randomly assigned to a five-step knee adjustment manipulation (FS) group or a sham manipulation (SM) group with a ratio of 1:1. Each group will receive 2 sessions per week applied for 4 weeks and then be followed up for another 8 weeks. The primary outcome is visual analogue scale (VAS). The secondary outcomes include Western Ontario and McMaster Universities Arthritis Index (WOMAC) score, ROM, quadriceps cross-sectional area (CSA), gait analysis, and so on.</p><p><strong>Conclusion: </strong>This technique emphasizes a holistic approach, addressing the lumbar spine, hip, knee, and ankle joints, as well as related muscle groups, to correct lower limb alignment and restore muscle and bone balance. We think it will contribute to providing a promising alternative intervention for middle-aged and older adults with KOA.</p><p><strong>Trial registration: </strong>The study was approved by the Ethics Committee of Shanghai Municipal Hospital of Traditional Chinese Medicine (Ethics No.: 2024SHL-KY-70-01). Registered in Chinese Clinical Trial Registry (No. ChiCTR2400085536).</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1775-1791"},"PeriodicalIF":2.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-Guided Sural Nerve and Tibial Nerve Block Provides Comparable Analgesia to Popliteal Sciatic Nerve Block Following Calcaneal Surgery: A Single Center Randomized Controlled Double-Blind Study.","authors":"Jun Yao, Jialin Cai, Qingwang Lu, Xiaojing Huang","doi":"10.2147/JPR.S506049","DOIUrl":"10.2147/JPR.S506049","url":null,"abstract":"<p><strong>Background: </strong>Popliteal sciatic nerve blocks have gained popularity as an anesthesia choice for calcaneal surgery. While the simpler technique of sural and tibial nerve blocks offers potential, its safety and efficacy require validation through a head-to-head clinical study. This study compared the efficacy of ultrasound-guided sural and tibial nerve blocks (ST) with popliteal sciatic nerve block (PS) for operative and postoperative analgesia.</p><p><strong>Methods: </strong>A total of 80 patients (40 per group) undergoing calcaneal surgery were randomized to receive either ST or PS nerve blocks. Patients in both groups were provided with an intravenous patient-controlled analgesia (PCA) device containing flurbiprofen. Visual analogue scale (VAS) pain scores were recorded at awakening, 2, 6, 12, and 24 h postoperatively. In addition, block onset time, procedure duration, patient satisfaction, and application of postoperative analgesics were also recorded.</p><p><strong>Results: </strong>VAS scores were comparable between groups throughout the 24-hour observation period (VAS range 0-3, p > 0.05). ST blocks demonstrated faster onset (8.2 ± 1.5 vs 12.4 ± 2.1 minutes, p<0.001) and shorter procedure time (11.5 ± 2.1 vs 16.8 ± 2.4 minutes, p<0.001). Patient satisfaction scores were similar between groups (8.5 ± 0.8 vs 8.3 ± 0.9, p=0.31).</p><p><strong>Conclusion: </strong>Ultrasound-guided sural and tibial nerve blocks provide effective operative and postoperative analgesia comparable to popliteal sciatic nerve block. The blocks are easy to perform, have a faster onset, and achieve high patient satisfaction, making them a valuable alternative for calcaneal surgery.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1765-1773"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Placebo Hypoalgesic Response Is Reduced in Healthy Older Adults Showing a Decline in Executive Functioning.","authors":"Katharina M Rischer, Angelika M Dierolf, Fernand Anton, Pedro Montoya, Ana M González-Roldán, Marian van der Meulen","doi":"10.2147/JPR.S488198","DOIUrl":"10.2147/JPR.S488198","url":null,"abstract":"<p><strong>Purpose: </strong>Aging is accompanied by various changes in pain perception and modulation. However, the influence of older age - and associated neurocognitive changes - on placebo hypoalgesia has not been systematically investigated. Findings to date are inconclusive, ranging from a reduced, to a preserved or even an amplified response in older adults. The aim of this study was to examine age-related changes in the placebo hypoalgesic response magnitude, and the potential modulating effect of executive functions, namely working memory, cognitive flexibility and inhibitory control.</p><p><strong>Methods: </strong>Thirty-nine younger (18-36 years) and 42 healthy older adults (60-82 years) completed a series of executive functioning tests. Placebo hypoalgesic responding was assessed via a sham transcutaneous electrical nerve stimulation (TENS) intervention while participants received moderately painful electrical stimuli to their arm. An electroencephalogram (EEG) was recorded during the placebo paradigm and pain ratings were collected.</p><p><strong>Results: </strong>Overall, both age groups showed similar robust placebo hypoalgesic effects: pain ratings and pain-related brain potentials were significantly reduced in response to the sham treatment. Interestingly, worse executive functions in older adults (in particular, working memory and cognitive flexibility) were associated with reduced placebo responses. Moreover, executive functions also moderated the overall age group difference in placebo hypoalgesia: when cognitive flexibility and inhibitory control scores were low, older adults showed a smaller placebo response than younger adults.</p><p><strong>Conclusion: </strong>We demonstrated an age-related reduction in placebo hypoalgesia in older adults showing a decline in executive functioning. This is an important finding, considering the fact that placebo effects contribute to positive treatment outcomes. Our results advocate the assessment of executive functions when investigating the influence of aging on placebo effects, as variable aging trajectories of decline may influence overall group comparisons.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1747-1763"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent Profile Analysis of Pain Catastrophizing in Post-Operative Lung Cancer Patients.","authors":"Xinyan Wu, Tao Xu, Ping Cai, Siwen Shen, Mengchen Ji, Qing Liu, Xiaobo Wang, Mingqi Zhang, Shiming Wang, Danfeng Gu","doi":"10.2147/JPR.S507027","DOIUrl":"10.2147/JPR.S507027","url":null,"abstract":"<p><strong>Background: </strong>Patients with lung cancer often experience high levels of pain and recurrent pain episodes after thoracoscopic surgery, compromising their adherence to rehabilitation exercises and quality of life. Pain catastrophizing is defined as an exaggerated and negative mindset towards actual or anticipated pain and is one of the significant factors influencing pain. To date, prior investigations on pain catastrophizing have predominantly employed variable-centered approaches, focusing on broader population levels while neglecting individual specificity. Latent profile analysis represents an individual-centered data analysis method that can accurately identify distinct phenotypic subgroups and deeply analyze the characteristics of each subgroup. This enables clinicians to identify high-risk patients early and provide precision interventions to reduce pain catastrophizing and ultimately alleviate postoperative pain burden. Stratification-guided interventions play a crucial role in treating patients with pain catastrophizing, aligning with the principles of precision medicine.</p><p><strong>Methods: </strong>409 patients were included in this cross-sectional study. Latent profile analysis (LPA) was employed to discern distinct classes of pain catastrophizing among these patients. Chi-square tests, ANOVA, and multinomial logistic regression were conducted to analyze the factors influencing the different pain catastrophizing profiles among patients following thoracoscopic lung cancer surgery.</p><p><strong>Results: </strong>Three distinct latent classes of pain catastrophizing were identified, Class1, labeled \"Mild Pain Catastrophizing-Rumination Type\"(26.2% of participants), Class2, referred to as \"Moderate Pain Catastrophizing-Ruminative Exaggerative Type\"(33.2%), Class3, designated as \"Severe Pain Catastrophizing-Ruminative Helpless Exaggerative Type\"(40.6%). Unordered multinomial logistic regression analysis indicated that factors influencing mild pain catastrophizing included fatigue, perception of social support, marital status, primary caregiver, tumor location, and clinical stage. In contrast, factors influencing moderate pain catastrophizing included fatigue, perception of social support, marital status, education level, primary caregiver, and clinical stage (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Three distinct patterns of pain catastrophizing were identified in patients following lung cancer surgery, each exhibiting unique classification characteristics. Healthcare professionals should promptly identify individuals at high risk for pain catastrophizing and develop targeted interventions that address physiological, psychological, and social factors.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1735-1745"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Evidence for Causal Effects of Immune Cell Subtypes on Postherpetic Neuralgia.","authors":"Taichang Chen, Songjiang Tang, Rong Chen, Wei Ding, Ying Chen, Zhonglu Jian, Min Wu, Min Jia, Xiuyi Zhang","doi":"10.2147/JPR.S503748","DOIUrl":"10.2147/JPR.S503748","url":null,"abstract":"<p><strong>Background: </strong>Recent evidence indicates that immune cells are crucial in modulating the pathogenesis of postherpetic neuralgia (PHN), with significant associations identified between immune responses and the development of PHN. However, the specific dynamic immune profile, the underlying molecular mechanisms, and especially the causal relationship between immune cells and PHN have yet to be comprehensively elucidated.</p><p><strong>Methods: </strong>We implemented a comprehensive analytical framework incorporating two-sample Mendelian randomization (MR), multivariable Mendelian randomization(MVMR), and colocalization analyses to elucidate the causal relationships between immune cell phenotypes and PHN. Utilizing publicly available genetic datasets, we explored potential causal associations between 731 immune cell phenotypes and susceptibility to PHN. Comprehensive sensitivity analyses were performed to assess the robustness of the findings, evaluate heterogeneity, and investigate horizontal pleiotropy.The Steiger directionality test was utilized to address and reduce the likelihood of reverse causation.</p><p><strong>Results: </strong>After applying the Bonferroni-adjusted, eight immune cell phenotypes exhibited significant causal associations with PHN. Further MVMR analysis revealed a significant positive causal relationship between CD27 on IgD- CD38dim B cell and the risk of PHN, with an odds ratio (OR) of 1.228 (95% confidence interval [CI]: 1.059-1.566, P = 0.011). Colocalization analysis offered limited evidence supporting a shared genetic architecture.</p><p><strong>Conclusion: </strong>Our findings present compelling genetic evidence that identifies CD27 on IgD- CD38dim B cell as a potential therapeutic target for the prevention and treatment of PHN. This study reinforces the mechanistic connection between immune cell function and the pathogenesis of PHN, highlighting the necessity for further exploration in this area. These insights provide significant guidance for future clinical research and the development of therapeutic strategies.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1721-1734"},"PeriodicalIF":2.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hippocampal Subfields Related to Cognitive Decline and Peripheral TIM-3 Levels in Elderly with Knee Osteoarthritis.","authors":"Baoru Zhao, Xiaowen Lian, Peiling Zeng, Yajun Wang, Guiyan Cai, Ruilin Chen, Jiao Liu, Lidian Chen","doi":"10.2147/JPR.S496944","DOIUrl":"10.2147/JPR.S496944","url":null,"abstract":"<p><strong>Purpose: </strong>Knee osteoarthritis (KOA) has been linked to increased cognitive decline risk, but the specific mechanisms underlying this phenomenon remain unclear. Research suggests neuroimaging changes and chronic low-grade inflammation may play key roles as common pathways linking osteoarthritis (OA) to cognitive decline.</p><p><strong>Patients and methods: </strong>This cross-sectional study recruited 36 individuals diagnosed with KOA and 25 healthy controls (HCs). Cognition was assessed using the Montreal Cognitive Assessment (MoCA) and the Digit Cancellation Test (DCT). The gray matter volume of 12 hippocampal subfields and the serum TIM-3 levels were also measured.</p><p><strong>Results: </strong>KOA patients had significantly lower MoCA scores (<i>P</i> < 0.01) and fewer correct responses on the DCT (<i>P</i> < 0.01). They also exhibited a larger volume of the right hippocampal tail (FDR-corrected <i>P</i> = 0.010) and a smaller volume of the right hippocampal fissure (FDR-corrected <i>P</i> = 0.036). Correlation analysis revealed that the volume of the right hippocampal tail was associated with the number of correct responses on the DCT (r = -0.356, <i>P</i> = 0.049). Additionally, a smaller volume of the left hippocampal fissure was linked to higher serum TIM-3 levels (r = -0.404, <i>P</i> = 0.030) in KOA patients.</p><p><strong>Conclusion: </strong>The hippocampal tail and hippocampal fissure exhibited reduced volume in KOA patients, and these changes were associated with alterations in attention and serum TIM-3 levels, respectively. These findings suggest a potential link between KOA and cognitive decline through inflammation and neuroscience, offering a theoretical basis for further study. Meanwhile, serum TIM-3 and right hippocampal fissure/tail volume might be potential biomarkers for detecting cognitive decline in KOA patients. Further studies are necessary for the investigation of this possibility.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1697-1709"},"PeriodicalIF":2.5,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Percutaneous Spinal Endoscopic YESS Technique in Adjacent Segmental Disease Without Severe Instability After Lumbar Fusion Surgery: A Case Series.","authors":"Haitao Zou, Lingan Huang, Litao Zhao, Pengcui Li, Qiongrun Xiao, Xueqin Rong","doi":"10.2147/JPR.S488031","DOIUrl":"10.2147/JPR.S488031","url":null,"abstract":"<p><strong>Background: </strong>The adjacent segment disease (ASD) after lumbar fusion is inherently stressed abnormally, and the destruction of bony structures in surgery can further exacerbate that abnormality. The Yeung Endoscopic Spine Surgery (YESS) technique does not destroy facet joints, and therefore it may be a good indication for ASD. However, the efficacy of the YESS technique in ASD patients have not been reported.</p><p><strong>Patients and methods: </strong>From January 2018 to May 2023, 13 patients with adjacent spondylolisthesis secondary to lumbar fusion were treated with endoscopic YESS technique surgery. Patients' visual analog score (VAS) and Oswestry disability index (ODI) score were analyzed preoperatively, 3 days postoperatively, and at the final follow-up. Gait analysis parameters and intervertebral height index of patients preoperatively and at 1 year postoperatively were used to objectively quantify patient pain, function, and radiographic changes.</p><p><strong>Results: </strong>A total of 13 patients, 2 females and 11 males, had single-segment adjacent spondylolisthesis. The patients' VAS and ODI scores at 3 days postoperatively decreased (P<0.05) compared to preoperatively and further decreased (P<0.05) at the final follow-up. There were no infections, wound complications or reoperations. The results of gait analysis showed no statistically significant difference in single-stance time and the gait cycle before and after the patients' surgery (P>0.05), but the patients' velocity, step length, step time, step frequency and stride length were significantly improved at 1-year postoperatively (P<0.05). Intervertebral height loss did not occur in all patients.</p><p><strong>Conclusion: </strong>In the short term, spinal endoscopic YESS technique markedly improves clinical symptoms and gait parameters in patients with ASD without severe instability after lumbar fusion, while avoiding facet joint destruction and intervertebral height loss. Future studies with larger sample sizes and longer follow-up times are needed to clarify the long-term efficacy.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1711-1720"},"PeriodicalIF":2.5,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}