Journal of Pain Research最新文献

{"title":"Differences in the Effectiveness of Different Physical Therapy Modalities in the Treatment of Delayed-Onset Muscle Soreness: A Systematic Review and Bayesian Network Meta-Analysis.","authors":"Jing Chen, Qing Hu, Jiajie Hu, Songtao Liu, Linyu Yin","doi":"10.2147/JPR.S519242","DOIUrl":"https://doi.org/10.2147/JPR.S519242","url":null,"abstract":"<p><strong>Purpose: </strong>Delayed-onset muscle soreness (DOMS) is a common clinical condition that frequently affects various populations. Physical therapy offers distinct advantages in managing this condition. However, many recently published studies have produced conflicting results and lack compelling evidence, complicating clinicians' decision making. We employed a Bayesian meta-analysis to assess the efficacy and safety of physical therapy modalities (PTMs) for DOMS, aiming to provide robust, evidence-based medical insights for clinical application.</p><p><strong>Patients and methods: </strong>We conducted a comprehensive search for randomized controlled trials (RCTs) evaluating PTMs for DOMS across databases, including CNKI, CSCD, CCD, CBM, PubMed, EMbase, Cochrane Library, and Web of Science, until October 22, 2024. The included studies were assessed for risk of bias using the Cochrane Risk of Bias Assessment tool, tailored for RCTs. A network meta-analysis was performed using R v.4.2.2.</p><p><strong>Results: </strong>At 24 hours post-intervention, photobiomodulation therapy(PBMT) demonstrated a significant advantage over placebo (-3.91 [-5.57, -2.17],P<0.05). The effects of other therapies were not significant (Cryotherapy: -0.58 (-1.20, 0.11), Cryotherapy combined with PBMT: 0.48 (-1.09, 2.01), ES: -0.98 (-2.82, 0.89), Irradiated: -0.10 (-1.71, 1.53), STM: -0.89 (-2.63, 0.85), UT: -0.61 (-1.92, 0.84)).At 48 hours post-intervention, both PBMT (-5.24 [-6.95, -3.20],P<0.05) and sauna (-3.29 [-6.21,-0.33],P<0.05) exhibited significant effects compared to placebo.The effects of other therapies were not statistically significant.; However, beyond 48 hours, there was no notable benefit from PTMs when compared with placebo, indicating that PTMs are more effective within the initial 48 hours, with PBMT yielding superior outcomes.</p><p><strong>Conclusion: </strong>The findings from this investigation indicate that PBMT and sauna treatment produce significant effects within the first 48 hours; however, beyond this period, the impact of photobiomodulation diminishes significantly. Overall, physical therapy modalities are the most effective within the 48-h window.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2993-3008"},"PeriodicalIF":2.5,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12178262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Perceptions on Opioid Therapy for Acute Pain Management in the Emergency Department and Post-Surgical Settings: A Qualitative Study.","authors":"Evan Lucey, Erica Dean, Brittany P Chapman, Richard Perugini, Peter Chai, Charlotte E Goldfine, Stephanie Carreiro","doi":"10.2147/JPR.S518088","DOIUrl":"10.2147/JPR.S518088","url":null,"abstract":"<p><strong>Purpose: </strong>Opioids are highly effective in treating acute pain but have various detrimental, non-therapeutic effects that may lead to the development of opioid use disorder (OUD) in certain individuals. This creates a complex landscape of opioid prescribing and use. The present manuscript uses a qualitative research lens to understand the patient experience during opioid therapy for acute pain, including perceptions, behaviors, and factors that drive both during the third wave of the opioid epidemic.</p><p><strong>Patients and methods: </strong>Patients receiving opioids for acute pain were recruited from the emergency department and general surgery clinic as part of a larger study to perform continuous physiologic monitoring during opioid use. Semi-structured interviews were conducted within 10 days of hospital discharge. Interviews were recorded, transcribed verbatim and subject to applied thematic analysis by two independent coders.</p><p><strong>Results: </strong>Of the 60 subjects that completed the parent study, 44 completed the semi-structured interviews (mean age 47 years, 50% female). Three main themes emerged from the interviews: the direct effects of opioid analgesia, internal factors and external factors that influenced therapy. Symptoms of opioid tolerance, withdrawal and dependence were described in a subset of participants, even with a relatively short duration of therapy. Participants expressed a desire for more education around opioid therapy, and more engagement with their plan of care.</p><p><strong>Conclusion: </strong>Opioid therapy, even in short courses for acute pain, can be a complicated experience for patients to navigate. Prescribers should consider how patients' unique experiences and perspectives shape their responses when providing counseling to patients and monitoring of response to opioid therapy.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2961-2972"},"PeriodicalIF":2.5,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-Guided the Prevertebral Fascia Incise and the C5 Root Hydrodissection for the Treatment of Neurogenic Thoracic Outlet Syndrome: an Application Study.","authors":"Zhenlan Liao, Yajing Zhou, Wen Cao","doi":"10.2147/JPR.S524917","DOIUrl":"10.2147/JPR.S524917","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this retrospective study was to evaluate the effectiveness of ultrasound-guided hydrodissection of the C5 nerve root, in combination with prevertebral fascia incision, as a treatment for neurogenic thoracic outlet syndrome (NTOS).</p><p><strong>Methods: </strong>Between January 2023 and January 2024, a total of 34 patients diagnosed with NTOS were enrolled in the treatment group, all of whom underwent ultrasound-guided hydrodissection of the C5 nerve root and prevertebral fascia incision. A control group consisting of 34 healthy participants was also included for comparative purposes. Preoperative and postoperative ultrasound measurements were taken at 1 and 6 weeks, including the thickness of the prevertebral fascia, the distance between the C5 nerve root and fascia, and the cross-sectional area (CSA) of the C5 nerve root. Pain intensity and functional status were assessed using the Visual Analog Scale (VAS) and Disabilities of the Arm, Shoulder, and Hand (DASH) scores.</p><p><strong>Results: </strong>Preoperative measurements in the NTOS group showed increased prevertebral fascia thickness (median: 0.1 mm [IQR 0.08-0.12]), reduced distance between the C5 nerve root and the fascia (median: 0.13 mm [IQR 0.10-0.16]), and a larger CSA of the C5 nerve root (median: 0.08 mm² [IQR 0.06-0.10]). Post-treatment, VAS scores significantly improved from a median of 7 (IQR 6-8) to 2 (IQR 2-3) at 1 week and remained stable at 6 weeks, while DASH scores improved from 85 (IQR 82-89) to 34 (IQR 31-36) at 1 week and 33 at 6 weeks.</p><p><strong>Conclusion: </strong>Ultrasound-guided hydrodissection of the C5 nerve root, along with prevertebral fascia incision, is an effective, minimally invasive treatment for NTOS.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2973-2982"},"PeriodicalIF":2.5,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective Dosage of Ciprofol for the Induction of General Anesthesia Across Diverse Age Groups in Adults: A Single-Center, Prospective, Non-Randomized Sequential Trial.","authors":"Lizhen Deng, Chunyuan Zhang, Meiyun Tan, Wei Zeng, Guozhan Luo, Ping Li","doi":"10.2147/JPR.S496223","DOIUrl":"10.2147/JPR.S496223","url":null,"abstract":"<p><strong>Purpose: </strong>A new Chinese-developed intravenous anesthetic called ciprofol enhances propofol's effectiveness against GABAA receptors by adding cyclopropyl. This study aims to determine the optimal dosage of ciprofol for inducing general anesthesia in adult patients of different ages and its correlation with Narcotrend index (NTI).</p><p><strong>Patients and methods: </strong>105 patients were stratified into three age groups: 18-40 (Group A), 41-65 (Group B), and 66-85 (Group C) years. Initial doses of 0.4 mg/kg (Groups A and B) and 0.3 mg/kg (Group C) ciprofol tosilate were administered, adjusted by 0.05 mg/kg based on sedation efficacy. The Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scale and Dixon up-and-down method were used to calculate ED50, ED95, and NTI50.</p><p><strong>Results: </strong>Effective dosages were: youth (ED50=0.526 mg/kg, ED95=0.610 mg/kg), middle-aged (ED50=0.366 mg/kg, ED95=0.450 mg/kg), and elderly (ED50=0.324 mg/kg, ED95=0.408 mg/kg). NTI50 were 38.068 (33.496-44.188), 44.963 (39.311-52.270), and 47.214 (39.792-57.420) for the three groups, respectively.</p><p><strong>Conclusion: </strong>Ciprofol is safe and effective for anesthesia induction across age groups, with lower doses required for elderly patients. NTI reduction was dose-dependent and slower in elderly patients.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2983-2992"},"PeriodicalIF":2.5,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12175962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multi-Site, Randomized, Parallel-Group, Controlled Trial of Virtually-Delivered Sahaj Samadhi Meditation for the Management of Moderate Depressive Symptoms in Chronic Pain.","authors":"Darren K Cheng, Robert Simpson, Rahim Moineddin, Joel Katz, Benoit H Mulsant, Akshya Vasudev, Michelle Greiver, Fardous Hosseiny, Marco Inzitari, Ronnie I Newman, Leon Rivlin, Kirk D Foat, Andrea D Furlan, John Francis Flannery, Deanna Telner, Rachael Bosma, Michelle Naimer, Chadwick Chung, Andrew D Pinto, Michelle L A Nelson, Ross Upshur, Abhimanyu Sud","doi":"10.2147/JPR.S515229","DOIUrl":"10.2147/JPR.S515229","url":null,"abstract":"<p><strong>Background: </strong>Chronic pain (CP) often co-occurs with depression, but promising scalable interventions have been under-investigated. We assessed the effectiveness of the virtually-delivered Sahaj Samadhi Meditation (SSM) program in reducing depressive symptoms in people with CP and moderate depressive symptoms.</p><p><strong>Methods: </strong>We conducted a randomized controlled trial comparing SSM to the Health Enhancement Program (HEP), an active control. Participants were recruited from multiple sites in the Greater Toronto Area and virtually. Both 12-week programs were delivered virtually in groups by appropriately trained facilitators. Depressive symptoms were assessed using the Patient Health Questionnaire (PHQ-9) at baseline, 12 weeks, and 24 weeks. ClinicalTrials.gov registration number: NCT04039568.</p><p><strong>Results: </strong>Of 108 participants enrolled, 89 were randomized to SSM (n=43) or HEP (n=46). Between-group differences for the PHQ-9 were not significant. Within-group mean differences for SSM were significant and greater than the minimal clinically important difference at both 12 weeks and 24 weeks (-3.97 (95% CI -6.69 to -1.24) and -4.96 (-8.36 to -1.56), respectively), while within-group mean differences were not significant for HEP.</p><p><strong>Conclusion: </strong>This study suggests potential benefits of SSM for individuals with comorbid CP and depression. Future trials should include larger sample sizes in non-pandemic conditions to better evaluate the effectiveness of SSM. Further research should also explore pragmatic trial designs and the integration of mind-body interventions in clinical settings.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2925-2946"},"PeriodicalIF":2.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Locoregional Vs General Anesthesia on Incidence of Delayed Neurocognitive Recovery in Patients Undergoing Hip Fracture Surgery: A Randomized Controlled Trial.","authors":"Shuqi Xie, Xi Zhao, Zitong Zhao, Min Gui, Xiaodan Cao, Xiyuan Shen, Junjie Luo, Xiaorui Chen, Yuxuan Xia, Bin Yu","doi":"10.2147/JPR.S523812","DOIUrl":"10.2147/JPR.S523812","url":null,"abstract":"<p><strong>Purpose: </strong>Delayed neurocognitive recovery is common in elderly patients undergoing major surgery under general anesthesia. We conducted a randomized controlled trial to examine whether continuous femoral nerve block plus sacral plexus block reduces the rate of delayed neurocognitive recovery in patients undergoing hip surgery.</p><p><strong>Methods: </strong>This is a single-centre, randomized controlled trial. Patients undergoing hip surgery were randomized (1:1 ratio) to undergo surgery under either continuous femoral nerve block plus sacral plexus block or general anesthesia. The primary end point was delayed neurocognitive recovery, as assessed using a battery of neuropsychological tests at 7 days after the surgery (<i>Z</i> score ≤-1.96 in at least 2 tests, and/or combined <i>Z</i> score ≤-1.96), in a modified intent-to-treat population. Secondary end points included postoperative complications, moderate/severe postoperative pain (visual analogue scale ≥4), use of opioids within 48 hours, and 6-month all-cause mortality.</p><p><strong>Results: </strong>A total of 168 patients were enrolled from January 2018 to May 2021. One hundred and sixty were included in the analysis (81 and 79 in the nerve block and general anesthesia, respectively). The rate of delayed neurocognitive recovery was 7.4% (6/81) in the continuous femoral nerve block plus sacral plexus block group versus 21.5% (17/79) in the general anesthesia group (odds ratio: 0.34, 95% CI: 0.14-0.83; P = 0.01). The rate of postoperative pulmonary infection was 1.2% (1/81) in the nerve block group versus 10.1% (8/79) in the general anesthesia group OR 0.12 (95% CI 0.02,0.95; P = 0. 02). No patient died within 6 months after surgery.</p><p><strong>Conclusion: </strong>When compared with general anesthesia, continuous nerve block anesthesia might decrease the incidence of delayed neurocognitive recover in patients undergoing hip fracture surgery. The locoregional anesthesia technique for patients undergoing hip surgery offers a safer alternative that lowers the risk of complications.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2947-2960"},"PeriodicalIF":2.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fu's Subcutaneous Needling Combined with Kinematic Acupuncture versus Electroacupuncture in the Treatment of Cervical Spondylotic Radiculopathy: A Randomized Controlled Trial [Letter].","authors":"Xiaofeng Pan, Qiang Liu","doi":"10.2147/JPR.S541139","DOIUrl":"10.2147/JPR.S541139","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2923-2924"},"PeriodicalIF":2.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12170354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy of Electroacupuncture in the Treatment of Chronic Neck Pain: A Randomized Clinical Trial.","authors":"Wenting Li, Xiaoyang Liu, Jiahui Lin, Jianpeng Huang, Sheng Li, Nenggui Xu, Wenbin Fu, Jianhua Liu","doi":"10.2147/JPR.S515679","DOIUrl":"10.2147/JPR.S515679","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic neck pain (CNP) is a common but challenging symptom in clinical practice. Acupuncture is widely used in alleviating the symptoms of CNP. The main objective of this study was to evaluate the efficacy and safety of electroacupuncture (EA) in patients with CNP and to quantify the specific effects of EA by controlling for placebo effects.</p><p><strong>Patients and methods: </strong>A randomized sham-controlled trial was conducted at the outpatient departments of single hospital in China from November 2019 to November 2020 and a total of 105 participants with CNP were enrolled. Participants were randomly assigned (1:1:1) to the EA group, sham electroacupuncture (SEA) group and waiting list (WL) group. The primary outcome was change in the Northwick Park Neck Pain Questionnaire (NPQ). Secondary outcomes included McGill Pain Questionnaire (MG), visual analogue scale (VAS) and pain threshold (PT).</p><p><strong>Results: </strong>This randomized clinical trial included 98 patients. The EA group demonstrated a greater reduction in NPQ scores compared to the SEA group after 10 sessions (-7.2564, 95% CI=-12.2875 to -2.2253, <i>P</i>=0.0054) and at 3-month follow up (-7.0090, 95% CI=-10.5039 to -3.5140, <i>P</i>=0.0002). After 10 sessions, the EA and SEA groups exhibited greater reductions in NPQ scores compared to the WL group (EA vs WL: <i>P</i> <b><</b>0.001, [95% CI=6.570 to 15.503]; SEA vs WL: <i>P</i>=0.027, [95% CI=0.578 to 9.580]). However, the EA group achieved clinically significant NPQ improvements (>25%), whereas the SEA group failed to meet this criterion.</p><p><strong>Conclusion: </strong>This randomized clinical trial found that, in patients with CNP, EA significantly improved the symptoms compared with SEA and WL groups both immediately and cumulatively (at 5 weeks), and these benefits persisted through week 17. These comparisons demonstrated that EA's clinical benefits exceeded placebo effects.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2909-2922"},"PeriodicalIF":2.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12169039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic Study on the Therapeutic Effects of Juanbi Lijieqing Formula in a Rat Model of Gouty Arthritis with Hyperuricemia.","authors":"Yifan Lu, Chengyin Lu, Gonghui Jian, Hui Xiong, Yang Shu","doi":"10.2147/JPR.S517711","DOIUrl":"10.2147/JPR.S517711","url":null,"abstract":"<p><strong>Background: </strong>This study evaluated the therapeutic effects and underlying mechanisms of Juanbi Lijieqing Formula (JBLJQF) in a rat model of gouty arthritis with hyperuricemia.</p><p><strong>Methods: </strong>Forty-two rats were randomly assigned to seven groups: control, model, etoricoxib, benzbromarone, and low-, medium-, and high-dose JBLJQF. General condition, joint swelling, behavioral performance, biochemical markers, and histopathology were assessed. Urate Anion Transporter 1(URAT1) expression was examined via immunofluorescence and Western blot.</p><p><strong>Results: </strong>JBLJQF improved general condition, reduced joint swelling, and alleviated kidney damage. Medium- and high-dose groups showed enhanced pain threshold and locomotor activity. Serum uric acid, TNF-α, and IL-1β levels were significantly decreased. URAT1 expression was downregulated, suggesting reduced renal urate reabsorption.</p><p><strong>Conclusion: </strong>JBLJQF exerts anti-inflammatory, uric acid-lowering, and organ-protective effects in gouty arthritis with hyperuricemia, highlighting its potential for clinical application.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2865-2877"},"PeriodicalIF":2.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered Brain Functional Connectivity and Neurometabolite Correlations in Orofacial Chronic Pain with Central Sensitization.","authors":"Makoto Terumitsu, Yuhei Takado, Ken-Ichi Fukuda, Eisuke Kato, Sei Tanaka, Khin Khin Tha","doi":"10.2147/JPR.S507893","DOIUrl":"10.2147/JPR.S507893","url":null,"abstract":"<p><strong>Purpose: </strong>Central sensitization (CS) is one of the causes of refractory chronic orofacial pain (COFP). Chronic pain reportedly alters resting-state functional connectivity (FC) in the brain. The salience network (SN) overlaps with brain regions involved in chronic pain. Moreover, excitatory and inhibitory neural activities can alter FC. This study investigated the correlations between FC of the SN and other neural circuits, neurometabolites in anterior cingulate cortex (ACC), and CS Inventory (CSI) scores.</p><p><strong>Patients and methods: </strong>Participants were 21 COFP patients and 21 healthy sex- and age-matched volunteers. We conducted a combined study of CSI scores, resting-state functional magnetic resonance imaging, and proton magnetic resonance spectroscopy of ACC.</p><p><strong>Results: </strong>FC between the nucleus accumbens within the mesolimbic system and SN regions was significantly stronger in patients compared with that in controls. In patients, the results revealed positive correlations between CSI scores and FC in four pairs of regions: ACC-right putamen and ACC-right globus pallidus, left insula-right putamen, and right anterior supramarginal gyrus-right lateral prefrontal cortex. Regarding correlations between neurometabolites in ACC and FC between ACC and other cortical regions, the results revealed that bilateral ACC-anterior insula FC was negatively correlated with glutamate, glutamine, and glutathione. Additionally, aspartate, an N-methyl-D-aspartic acid receptor agonist, was negatively correlated with FC of ACC-right parietal cortex in the default mode network. Regarding FC of bilateral ACC-posterior parietal cortex in the frontoparietal network, FC on the right side was positively correlated with glutathione associated with excitatory neuronal activity, whereas that on the left side was negatively correlated with gamma-aminobutyric acid / total creatine associated with inhibitory neural activity.</p><p><strong>Conclusion: </strong>Connectivity within the SN, and between the SN and the mesolimbic system and other networks, may be involved in CS in COFP. Neurometabolites in the ACC may modulate FC linked to the ACC.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2849-2863"},"PeriodicalIF":2.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}