Journal of Pain Research最新文献

{"title":"Efficacy of Acupuncture in Treating Nape Back Myofascial Pain Syndrome: a Comprehensive Systematic Review and Meta-Analysis.","authors":"PeiZhen Zhang, YuJing Zhang, Meng Guo","doi":"10.2147/JPR.S509967","DOIUrl":"10.2147/JPR.S509967","url":null,"abstract":"<p><strong>Introduction: </strong>Acupuncture, in particular, has received increasing attention in pain management in traditional medicine treatments. This study evaluated the effectiveness of acupuncture in treating nape back myofascial pain syndrome (MPS).</p><p><strong>Methods: </strong>The literature on randomized controlled trials of acupuncture in the treatment of nape back MPS was retrieved by searching nine databases. Review Manager 5.4 software was used to merge and statistically analyze the extracted data, and Stata 18.0 was used to assess the risk of bias.</p><p><strong>Results: </strong>Finally, 10 randomized controlled trials were included, with a total of 624 samples. The meta-analysis results indicated that acupuncture therapy could lower the NDI score [MD=-6.64, 95% CI (-10.95, -2.33), Z = 3.02, P = 0.003]. Acupuncture demonstrated superiority over the control group in addressing nape back myofascial pain condition, which reflected that the VAS score of the acupuncture treatment group was significantly lower than that of other treatment controls [SMD=-0.71, 95% CI (-1.07, -0.36), Z = 3.94, P < 0.0001]. Furthermore, in contrast to the control group, the improvement of PPT and right flexion CROM and rotation CROM in the acupuncture group was more evident (PPT: [MD = 0.95, 95% CI (0.63, 1.27), P < 0.001]) (right flexion CROM: [MD = 4.86, 95% CI (1.61, 8.12), P = 0.003]), (rotation CROM: [MD = 0.52, 95% CI (0.43,0.61), P < 0.00001]).</p><p><strong>Conclusion: </strong>This study demonstrates that acupuncture is more effective in treating nape back MPS than the control group and provides strong evidence for the effectiveness of acupuncture in treating nape back MPS, filling a gap in the treatment of nape back MPS by Traditional Chinese Medicine.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1667-1681"},"PeriodicalIF":2.5,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Recovery After Surgery (ERAS) Protocols in Orthopaedic Surgery: Opioids or Not Opioids?","authors":"Paolo Grossi","doi":"10.2147/JPR.S496891","DOIUrl":"10.2147/JPR.S496891","url":null,"abstract":"<p><p>Enhanced Recovery After Surgery (ERAS) protocols have transformed perioperative care in orthopaedic surgery, emphasising streamlined patient pathways for improved outcomes and treatment of chronic pain. Traditionally, opiates have been pivotal in managing postoperative (PO) pain and their efficacy in providing essential relief during the recovery phase is well-established. However, the evolving landscape of perioperative care, coupled with the opioid crisis and their association with chronic pain, has prompted a re-evaluation of their role. Orthopaedic ERAS protocols emphasise a multimodal approach to pain management, advocating for a reduction in opioid reliance. Alternative analgesic strategies, such as regional nerve blocks and non-opioid medications, are integrated into these protocols. Studies comparing opiates and opioid-free analgesia in orthopaedic ERAS are limited, making it challenging to establish a standardised approach. Some evidence suggests that opioid-free strategies, in some operating settings, may lead to improved recovery outcomes, reduced PO pain, and lower opioid consumption. However, in orthopaedics, evidence is inconclusive, necessitating further exploration. This review provides an overview of the development and multifaceted nature of ERAS protocols, which encompass a holistic approach to perioperative pain management and sustained pain relief, all while aiming to reduce the risks associated with opioid use. Striking the optimal balance between pain control and patient safety remains a priority, with the need for continued exploration and refinement of clinical guidelines in orthopaedics.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1683-1695"},"PeriodicalIF":2.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11962643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Socioeconomic Status on the Risk of Intervertebral Disc Degeneration and Low Back Pain in the European Population and the Mediating Role of Obesity-Related Traits: Evidence from a Mendelian Randomization Study.","authors":"Zhou Long, Qian Qin","doi":"10.2147/JPR.S501083","DOIUrl":"10.2147/JPR.S501083","url":null,"abstract":"<p><strong>Objectives: </strong>To identify the causal effect of socioeconomic status (SES) on intervertebral disc degeneration (IVDD) and low back pain risk through Mendelian Randomization (MR) analysis, and to evaluate the mediating role of obesity-related traits in these causal associations.</p><p><strong>Methods: </strong>Genome-wide association summary statistics for SESs ([i] years of schooling, [ii] occupational attainment, [iii] Townsend deprivation index, [iv] job involves heavy manual or physical work, and [v] average total household income before tax), obesity-related traits ([i] body mass index [BMI], [ii] waist circumference, and [iii] hip circumference), IVDD, and low back pain, were obtained from public databases. Inverse variance weighted (IVW) was the primary causal inference approach. Through two-step mediation MR analysis, key obesity-related traits mediating the causal effect of SES on the risk of IVDD and low back pain were identified.</p><p><strong>Results: </strong>This MR study supported that years of schooling reduced the risk of IVDD and low back pain, while the Townsend deprivation index and jobs involving heavy manual or physical work increased the risk of IVDD and low back pain. Additionally, occupational attainment and average total household income before tax reduced the risk of low back pain. Mediation MR analysis indicated that BMI and waist circumference mediated the causal effect of years of schooling, and BMI mediated the causal impact of average total household income before tax.</p><p><strong>Conclusions: </strong>This MR study provided evidence for the causal effect of genetically determined SES on the risk of IVDD and low back pain and revealed the potential mediating effect of obesity-related traits.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1627-1641"},"PeriodicalIF":2.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectral Analysis of Bioelectrical Activity in Experimentally Provoked Referred Pain - Motor Alterations Related to the Network of Trigger Points.","authors":"Mariusz Konieczny, Jakub Matuska, Przemysław Domaszewski, Paweł Pakosz, Pablo Herrero, Manel M Santafe, Daria Wotzka, Dariusz Zmarzły, Elżbieta Skorupska","doi":"10.2147/JPR.S475606","DOIUrl":"10.2147/JPR.S475606","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates bioelectrical changes in thigh muscles associated with referred pain following noxious stimulation of the gluteus minimus, focusing on understanding motor alterations related to the network of trigger points. While previous research suggested atypical autonomic activity, motor alterations in referred pain areas remain understudied. Thus, our aim was to investigate motor alternations using spectral analysis.</p><p><strong>Methods: </strong>Sixty-three participants were selected based on tests for atypical autonomic reactivity within the referred zone. The control group (CON) comprised 15 out of 48 healthy volunteers with negative test results, while the experimental group (EXP) included 13 out of 15 Polish national Short Track athletes with positive test results. They underwent a 10-minute surface electromyography session during gluteus minimus dry needling. Power spectral density analysis was then applied to assess the obtained signals.</p><p><strong>Results: </strong>Significant statistical differences in power spectral density were observed between the EXP and CON groups in thigh muscles, while no statistical differences were found in the pelvic girdle muscles. The most notable atypical bioelectrical activity was observed in the vastus lateralis, semitendinosus, and rectus femoris muscles.</p><p><strong>Results importance: </strong>Visualization of motor alterations related to the trigger point network in the thigh due to noxious stimulation of the gluteus minimus trigger points.</p><p><strong>Conclusion: </strong>Noxiously provoked referred pain from the gluteus minimus muscle, confirmed by abnormal autonomic activity, is characterized by motor alternations of the thigh muscles, suggesting a network of latent trigger points. Further studies exploring this observed phenomenon for both active and latent trigger points can provide new insights into myofascial pain syndrome.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1657-1666"},"PeriodicalIF":2.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and Safety of Platelet-Rich Plasma Combined with Pulsed Radiofrequency to Treat Patients with Infraorbital Neuralgia: A Propensity Score-Matched Analysis of a Multi-Center, Prospective Cohort Protocol.","authors":"Lu Liu, Dong Yang, Baolin Duan, Fang Luo","doi":"10.2147/JPR.S505263","DOIUrl":"10.2147/JPR.S505263","url":null,"abstract":"<p><strong>Background: </strong>Infraorbital neuralgia (IONa) is a rare but devastating type of facial pain, with a lack of current consensus on its proper management. Preliminary studies have established the efficacy of pulsed radiofrequency (PRF) in the treatment of IONa. Platelet-rich plasma (PRP) is a non-destructive technique that alleviates neuropathic pain. Till date, the efficacy of PRP combined with PRF in the treatment of IONa has not been evaluated yet.</p><p><strong>Objective: </strong>To evaluate the efficacy and safety of PRP combined with PRF in treating refractory IONa in patients unwilling to undergo destructive therapies.</p><p><strong>Study design: </strong>A multicenter, prospective, observational, propensity score matching (PSM), and assessor-blinded study.</p><p><strong>Setting: </strong>Department of pain management in Beijing, Wuhan and Qingdao, China.</p><p><strong>Methods: </strong>A total of 240 refractory IONa patients will be allocated to either PRP combined with PRF therapy (PRP+PRF) group or PRF therapy alone (PRF) group at their own volition. Statistical analysis will be performed using Pearson's chi-squared or Fisher's exact test for categorical variables, Student's <i>t</i>-test and Mann-Whitney <i>U</i>-test for continuous variables. Logistic regression will be used to evaluate the pain - relief efficacy.</p><p><strong>Results: </strong>The primary outcome will be the 12-months response rate. The secondary outcome will include NRS score, total daily dose of carbamazepine, the 12-item Short-Form Health Survey (SF-12) scores, patient satisfaction scores (PSS) and adverse events (AEs).</p><p><strong>Limitation: </strong>This is an observational, open-labeled study with a relatively short term follow-up. The composition of PRP and various cell ratios, which are optimal for IONa has not been published yet.</p><p><strong>Conclusion: </strong>This will be a multi-center trial with a relatively large sample size, demonstrating the potential benefits of PRP combined with PRF therapy in IONa patients. Further, randomized controlled trial (RCT) will be necessary to confirm the efficacy of this combined therapy.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1643-1656"},"PeriodicalIF":2.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Postoperative Pain in Pterygium Surgery Patients.","authors":"Guang Yang, Qingyu Li, Meiwen Tian, Meimei Liu, Tinghui Zhang, Wenjun Guo, Qiang Li","doi":"10.2147/JPR.S514070","DOIUrl":"10.2147/JPR.S514070","url":null,"abstract":"<p><strong>Purpose: </strong>Pterygium surgery is a common ophthalmological procedure, where effective management of postoperative pain is essential for ensuring patient satisfaction. This study aimed to investigate the risk factors for postoperative pain among Chinese patients undergoing pterygium excision surgery.</p><p><strong>Patients and methods: </strong>A total of 145 pterygium patients who underwent surgery from June 2020 to March 2021 at Shenzhen Eye Hospital were included. Anxiety levels were assessed using the Self-Rating Anxiety Scale before surgery, and pain levels were evaluated using the Numeric Rating Scale at various postoperative time points. Generalized linear model analysis was conducted with postoperative time-weighted average pain scores as the dependent variable and various potential risk factors as independent variables. These included traditional factors such as smoking history, alcohol history, ocular surgery history, and anxiety score as well as novel parameters like pterygium neck width, single- or double-headed pterygium, surgical corneal wound area, pterygium onset or recurrence, operating surgeon, congestion, pterygium invasion into the cornea, duration, graft conjunctival area, and preoperative pain score. We introduced the Shapley Additive exPlanations method to elucidate the contribution of these variables to time-weighted average pain scores.</p><p><strong>Results: </strong>Among the 145 patients, 96 reported postoperative pain. No statistically significant differences were observed in baseline characteristics-such as age, sex, history of systemic diseases, smoking, alcohol use, and prior eye surgeries-between patients who experienced postoperative pain and those who did not. Anxiety scores, surgeon, pterygium neck widths, and preoperative pain scores were found to be significant risk factors for pain scores (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>Preoperative anxiety scores were positively correlated with pain scores. Significant differences in postoperative pain scores were observed among patients who underwent operations by different surgeons. Patients with wider pterygium neck widths experienced more severe postoperative pain. Higher preoperative pain scores were associated with more severe postoperative pain.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1607-1614"},"PeriodicalIF":2.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subserratus Anterior Plane Block vs Thoracic Paravertebral Block for Postoperative Analgesia in Laparoscopic Radical Nephrectomy: Protocol for a Randomized Controlled, Double-Blind, Non-Inferiority Clinical Trial.","authors":"Jianghuai Lin, Huanghui Wu, Zhibin Wen, Yangyi Li, Changcheng Jiang, Binghong Lin, Yu Gu","doi":"10.2147/JPR.S506226","DOIUrl":"10.2147/JPR.S506226","url":null,"abstract":"<p><strong>Introduction: </strong>Thoracic paravertebral nerve block (TPVB) is a widely used regional anesthesia technique employed in opioid-sparing anesthesia for abdominal surgery. Although the subserratus anterior plane block (SSAPB) has shown effectiveness in providing analgesia in upper abdominal surgery, it remains unclear whether the SSAPB offers comparable analgesic effects to the TPVB for retroperitoneal laparoscopic nephrectomy.</p><p><strong>Methods and analysis: </strong>This study is designed as a prospective, randomized controlled, double-blind, single-center, non-inferiority trial involving a total of 106 patients undergoing retroperitoneal laparoscopic nephrectomy. Participants will be randomly assigned to either the SSAPB group or the TPVB group in a 1:1 ratio. Both ultrasound-guided SSAPB and TPVB will involve the administration of 0.375% ropivacaine at a dose of 0.4 mL/kg prior to anesthesia induction. Subsequently, opioid-sparing anesthesia will be utilized during surgery. Each patient will receive standardized patient-controlled intravenous analgesia (PCIA) without a background infusion. The primary outcome measure will be the 24-hour postoperative consumption of rescue opioids. Secondary outcomes will include pain visual analogue scale (VAS) scores at various predefined time points within 48 hours post-surgery, analgesic consumption during and after surgery, time to first administration of rescue analgesics, incidence of perioperative cardiopulmonary adverse events, assessment of block characteristics, quality of recovery, time to ambulation and initiation of an oral diet, and length of stay in both the postoperative anesthesia care unit (PACU) and the hospital. Additionally, levels of inflammatory markers, including interleukin-6 (IL-6) and C-reactive protein (CRP), will be assessed at predefined time points.</p><p><strong>Discussion: </strong>This protocol outlines the first prospective, randomized controlled, double-blinded, non-inferiority clinical trial comparing perioperative analgesic efficacy and safety of SSAPB versus TPVB in patients undergoing retroperitoneal laparoscopic nephrectomy under opioid-sparing anesthesia. The study is designed to generate preliminary insights into optimizing regional anesthesia strategies for perioperative pain management in this surgical cohort.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1615-1625"},"PeriodicalIF":2.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Muscle Elasticity and Pathological Characteristics Between Affected and Unaffected Sides in Postherpetic Neuralgia Patients: Protocol for a Pilot Cohort Trail.","authors":"Heyu Ji, Jiangyu Ma, Xulei Cui, Yuguang Huang","doi":"10.2147/JPR.S504823","DOIUrl":"10.2147/JPR.S504823","url":null,"abstract":"<p><strong>Background: </strong>Postherpetic neuralgia (PHN) is the most common condition that can develop as a complication after herpes zoster (HZ) infection, characterized by pain that persists for more than 3 months after the initial rash has resolved. In most patients with HZ, the rash appears unilaterally. While the treatment of PHN is primarily focused on neural mechanisms due to HZ's neurotropism nature, recent evidence suggests that muscle tissues within the affected regions may also experience pathological changes that contribute to the pain. These changes could reveal novel therapeutic targets and enhance patient prognosis. This study aims to investigate these muscular changes and explore myogenic pain mechanisms in PHN patients. It employs ultrasound elastography to compare muscle elasticity between the affected and unaffected sides and conduct muscle biopsies for pathophysiological analysis to uncover the underlying mechanisms.</p><p><strong>Materials and methods: </strong>This comparative cross-sectional study aims to enroll 30 PHN patients. The primary outcome is the comparison of muscle elasticity on the affected sides with unaffected sides. The secondary outcome is from muscle biopsies, which are obtained and analyzed by histopathological techniques. Pain levels before and after therapy are assessed using the Numerical Rating Scale (NRS), with follow-up to evaluate outcomes and satisfaction. Statistical analysis will employ paired <i>t</i>-tests or Wilcoxon signed-rank tests to compare muscle elasticity, and correlation analysis to explore the relationship between elasticity and pathological findings.</p><p><strong>Hypothesis: </strong>The study hypothesis is that muscle elasticity on the affected side is significantly higher than on the unaffected side, with the coexistence of myofascial pain. This myofascial pain may overlap with PHN pain and may be a source of discomfort in refractory PHN cases. Furthermore, muscle biopsies are conducted to clarify pathological changes. This study may pave the way for novel treatment strategies for PHN and establish a foundation for future research.</p><p><strong>Study registration: </strong>This study has obtained ethical approval from the Institutional Review Board of Peking Union Medical College Hospital on 28 August 2023 (I-23PJ1409) and is registered at ClinicalTrails.gov. Written informed consent has been obtained from all participants.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1597-1605"},"PeriodicalIF":2.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suzetrigine, a Non-Opioid Na_V1.8 Inhibitor With Broad Applicability for Moderate-to-Severe Acute Pain: A Phase 3 Single-Arm Study for Surgical or Non-Surgical Acute Pain.","authors":"Jessica McCoun, Peter Winkle, Daneshvari Solanki, Joshua Urban, Todd Bertoch, Jessica Oswald, Matthew W Swisher, Louise Anne Taber, Tiffany Healey, Ina Jazic, Darin J Correll, Paul A Negulescu, Carmen Bozic, Scott G Weiner","doi":"10.2147/JPR.S509144","DOIUrl":"10.2147/JPR.S509144","url":null,"abstract":"<p><strong>Background: </strong>Many patients experience inadequate pain control due to limited options that are both efficacious and safe for treating moderate-to-severe acute pain; therefore, opioids are still frequently prescribed for their effectiveness despite known tolerability issues and safety concerns. Suzetrigine, an oral, non-opioid, offers a promising alternative by selectively inhibiting the voltage-gated sodium channel 1.8 (Na_V1.8), a novel therapeutic target for pain management. Given the high selectivity of suzetrigine for Na_V1.8 (does not bind to other sodium channels/receptors with CNS activity), suzetrigine does not have CNS side effects or addictive potential associated with opioids. In the largest randomized, controlled phase 3 trials in established acute pain models, suzetrigine monotherapy demonstrated statistically significant and clinically meaningful reduction in moderate-to-severe acute pain compared to placebo.</p><p><strong>Methods: </strong>To evaluate the safety and effectiveness of suzetrigine for the treatment of moderate-to-severe-acute surgical and non-surgical pain conditions, we conducted a phase 3, single-arm study in adults with moderate or severe acute pain on the verbal categorical rating scale and ≥4 on the numeric pain rating scale following surgical procedures or after presenting to a medical facility with moderate or severe acute pain of new origin. Participants received suzetrigine (100mg then 50mg every 12hrs) for 14 days or pain resolution, whichever came first. The primary endpoint was safety. The secondary endpoint was participant perception of suzetrigine's effectiveness in treating acute pain at the end of treatment using a patient global assessment.</p><p><strong>Results: </strong>Suzetrigine was generally safe and well-tolerated in participants (N=256) with a range of surgical and non-surgical acute pain conditions; the maximum severity for most participants who had adverse events was mild (71 participants; 27.7%) or moderate (21 participants; 8.2%). Most participants (213 participants; 83.2%) rated suzetrigine's effectiveness for treating pain on a patient global assessment as good, very good, or excellent.</p><p><strong>Conclusion: </strong>Suzetrigine provides a safe and effective non-opioid, non-addictive treatment with broad applicability for moderate-to-severe acute pain.</p><p><strong>Clinicaltrialsgov registration: </strong>NCT05661734.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1569-1576"},"PeriodicalIF":2.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mentorship in Pain Medicine Fellowship: Addressing the Gaps and Advocating for Change.","authors":"Sayed E Wahezi, Ugur Yener, Peter S Staats, Yashar Eshraghi, Miles Day, Michael E Schatman, Scott G Pritzlaff","doi":"10.2147/JPR.S525160","DOIUrl":"10.2147/JPR.S525160","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1563-1567"},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}