Journal of Pain Research最新文献

{"title":"Effect of Acupuncture Intervention on Chronic Musculoskeletal Pain in Hemodialysis-Dependent Kidney Failure Patients: Study Protocol for a Randomized Controlled Clinical Trial.","authors":"Cuina Yan, Hui-Rong Liu, Qi Kong, Jia-Yi Gan, Kun Liu, Wei-Guo Yao, Xing-Mei Yao","doi":"10.2147/JPR.S492158","DOIUrl":"https://doi.org/10.2147/JPR.S492158","url":null,"abstract":"<p><strong>Background: </strong>Chronic musculoskeletal pain is prevalent in individuals with hemodialysis-dependent renal failure (HDKF). The current opioid crisis highlights the urgent need for effective non-pharmacological pain management. Acupuncture, identified as a non-pharmacological intervention in clinical settings, holds promise for alleviating chronic musculoskeletal pain in HDKF patients, but well-designed studies assessing its specific effects in this population are lacking. This study aims to comprehensively evaluate the efficacy and safety of acupuncture as a treatment modality for HDKF patients with chronic musculoskeletal pain.</p><p><strong>Methods: </strong>This trial, conducted at a single center, follows a parallel, three-arm design with randomization and sham control. 90 hDKF patients with chronic musculoskeletal pain will be assigned randomly to three groups (acupuncture, sham acupuncture, and waiting-list control) in a 1:1:1 ratio. The acupuncture and sham acupuncture groups will undergo 24 treatment sessions over eight weeks, while the waiting-list control group will receive no acupuncture. The primary outcome measures changes in the Numeric Rating Scale (NRS) score from baseline at the end of treatment, with secondary outcomes including the Edmonton Symptom Assessment System (revised version) (ESAS-r), Palliative care Outcome Scale (rental) (POS-renal), and hospital anxiety and depression scale (HADS). Adverse events will be recorded throughout the study, and all randomized patients will be included in the intention-to-treat analysis.</p><p><strong>Discussion: </strong>The outcomes of this research aim to advance the systematic management of chronic musculoskeletal pain in HDKF patients through non-pharmacological interventions. Moreover, it will contribute insights into personalized treatment strategies, integrating individual expectations and genetic biomarkers to provide \"precision\" acupuncture for HDKF patients experiencing chronic musculoskeletal pain.</p><p><strong>Trial registration: </strong>The trial registration number is ChiCTR2400080488. This trial was prospectively registered on 30 January 2024 in the Chinese Clinical Trial Registry.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"4289-4300"},"PeriodicalIF":2.5,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11654212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Preemptive Topical Lidocaine 5% Plaster in the Prevention of Post-Craniotomy Pain, a Randomized Clinical Trial.","authors":"Xueye Han, Yixuan Yang, Tong Ren, Nan Ji, Fang Luo","doi":"10.2147/JPR.S499264","DOIUrl":"https://doi.org/10.2147/JPR.S499264","url":null,"abstract":"<p><strong>Objective: </strong>The current landscape is characterized by a dearth of effective, safe, simple, and noninvasive methods for preventing pain following craniotomy. This clinical trial seeks to evaluate the efficacy profile of preemptive application of a topical 5% lidocaine patch in alleviating post-craniotomy pain.</p><p><strong>Methods: </strong>This was a multi-centric, prospective randomized placebo-controlled triple-blind clinical trial. Eligible patients were randomly assigned to either the masked intervention group, who received lidocaine 5% white hydrogel plasters (N = 90), or the placebo control group who received plain hydrogel plasters of the same pattern, size, appearance and material as L5Ps, but free of lidocaine (N = 90). Primary outcome was the pain intensity (Visual Analogue Scale at 24 h) after craniotomy. Secondary outcomes included: intra-operative analgesics consumption, pain intensity, cumulative rescue analgesics consumption, sleeping scores, adverse effects such as skin reactions, etc. The intention-to-treat analyses and the per-protocol analyses were used.</p><p><strong>Results: </strong>There were no statistically significant differences in the VAS scores at 24 h after craniotomy (P = 0.539). However, subgroup analysis for female and male patients showed that statistically significant differences were found in VAS scores in male patients (0 [0, 3] in the masked intervention group at 24 h after craniotomy and 3 [1, 4.5] in the placebo control group, P = 0.017). There were no obvious side effects directly associated with preemptive L5P.</p><p><strong>Conclusion: </strong>Preemptive lidocaine 5% plaster as a safe technique was not found to be effective in reducing post-craniotomy pain, but potential gender disparities in the outcomes of this method warrant further investigation.</p><p><strong>Trial registration: </strong>ClinicalTrials.Gov (NCT04169854).</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"4251-4261"},"PeriodicalIF":2.5,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Postoperative Management for PKP: Combining Traditional Chinese Medicine and Modern Rehabilitation Techniques [Letter].","authors":"Chen Zhou, Zhenhua Xu","doi":"10.2147/JPR.S509167","DOIUrl":"https://doi.org/10.2147/JPR.S509167","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"4249-4250"},"PeriodicalIF":2.5,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Kinesiotaping Reduce Pain in Rib Fractures?: A Randomized Prospective Study.","authors":"İsmail Dal, Özgür Bektaş, Sibel Kader, Gözde Bodur","doi":"10.2147/JPR.S500974","DOIUrl":"https://doi.org/10.2147/JPR.S500974","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study is to investigate the effect of kinesiotaping on pain scores in patients with rib fractures following isolated thoracic trauma.</p><p><strong>Materials and methods: </strong>In this randomized prospective study, patients with isolated thoracic trauma and rib fractures were randomized into kinesiotaping and control groups between January 24, 2024, and October 1, 2024. Patients in the control group received standard analgesic treatment. In the kinesiotaping group, kinesiotaping bands were applied in addition to the standard treatment. Pain scores using the visual analog scale (VAS) were recorded at admission, the 24th hour, the 4th day, and the 7th day, and the results were statistically compared.</p><p><strong>Results: </strong>A total of 118 patients were evaluated. Eighty-four patients did not meet the inclusion criteria. The 34 patients included in the study were randomized into kinesiotaping and control groups. The two groups were demographically homogeneous. On the 4th day, the mean VAS score was significantly lower in the kinesiotaping group (2.7 ± 1.2) compared to the control group (4.1 ± 1.9) (p = 0.037). No statistically significant difference in VAS scores was observed on the other days.</p><p><strong>Conclusion: </strong>In patients with rib fractures, pain scores decreased more rapidly in those treated with analgesics plus kinesiotaping compared to those treated with analgesics alone.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov, NCT06222320. Registered on January 15, 2024.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"4239-4247"},"PeriodicalIF":2.5,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compound Probiotics Improve Neuropathic Pain Prognosis in a Murine Model of Chronic Constriction Injury.","authors":"Xiaomei Wang, Yinsheng Chen, Shuwen Qian, Jia Kong, Zehua Su, Qingxiu Wang, Lijun Liao","doi":"10.2147/JPR.S486259","DOIUrl":"10.2147/JPR.S486259","url":null,"abstract":"<p><strong>Purpose: </strong>Compound probiotics have been reported to ameliorate imbalances in the intestinal flora that may play a critical role in neuropathic pain. This study aimed to investigate the efficacy of compound probiotic treatment on neuropathic pain.</p><p><strong>Methods: </strong>Thirty mice were randomly divided into three groups: 1) sham group, 2) mouse with chronic constrictive injury (CCI), and 3) probiotic gavage with CCI (CCI+Prob). The degree of pain and gait recovery was assessed by Mechanical withdrawal threshold (MWT), thermal withdrawal latency (TWL), and mouse footprints. The degree of atrophy of the gastrocnemius muscle was assessed by muscle weight, hematoxylin and eosin (H&E) staining. Gut microbiota were analyzed by 16S ribosomal RNA sequencing (16SrRNA).</p><p><strong>Results: </strong>Four weeks after surgery, TWL and MWT assessment showed significant increases in the CCI+Prob group compared with the CCI group (P < 0.01). Gait analysis results as well as gastrocnemius muscle weight showed a significant improvement in the CCI+Prob group compared with the CCI group. Measurement of alpha diversity showed a significant increase in the CCI group compared with the sham group, but this increase was attenuated by probiotic intervention in the CCI+Prob group. Although the CCI group had significantly decreased levels of Akkermansia and significantly increased levels of Ruminococcaceae, probiotic treatment reversed these changes.</p><p><strong>Conclusion: </strong>Compound probiotics treatment can improve the pain and muscle atrophy in mice with CCI-induced neuropathic pain. The improvement of symptoms is associated with changes in the composition of gut microbiota.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"4213-4221"},"PeriodicalIF":2.5,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Pain Management Clinic: The Role of AI-Integrated Remote Patient Monitoring in Chronic Disease Management - A Narrative Review.","authors":"Prachi M Patel, Maja Green, Jennifer Tram, Eugene Wang, Melissa Zhu Murphy, Alaa Abd-Elsayed, Krishnan Chakravarthy","doi":"10.2147/JPR.S494238","DOIUrl":"10.2147/JPR.S494238","url":null,"abstract":"<p><p>Remote Patient Monitoring (RPM) stands as a pivotal advancement in patient-centered care, offering substantial improvements in the diagnosis, management, and outcomes of chronic conditions. Through the utilization of advanced digital technologies, RPM facilitates the real-time collection and transmission of critical health data, enabling clinicians to make prompt, informed decisions that enhance patient safety and care, particularly within home environments. This narrative review synthesizes evidence from peer-reviewed studies to evaluate the transformative role of RPM, particularly its integration with Artificial Intelligence (AI), in managing chronic conditions such as heart failure, diabetes, and chronic pain. By highlighting advancements in disease-specific RPM applications, the review underscores RPM's versatility and its ability to empower patients through education, shared decision-making, and adherence to therapeutic regimens. The COVID-19 pandemic further emphasized the importance of RPM in ensuring healthcare continuity during systemic disruptions. The integration of AI with RPM has refined these capabilities, enabling personalized, real-time data collection and analysis. While chronic pain management serves as a focal area, the review also examines AI-enhanced RPM applications in cardiology and diabetes. AI-driven systems, such as the NXTSTIM EcoAI™, are highlighted for their potential to revolutionize treatment approaches through continuous monitoring, timely interventions, and improved patient outcomes. This progression from basic wearable devices to sophisticated, AI-driven systems underscores RPM's ability to redefine healthcare delivery, reduce system burdens, and enhance quality of life across multiple chronic conditions. Looking forward, AI-integrated RPM is expected to further refine disease management strategies by offering more personalized and effective treatments. The broader implications, including its applicability to cardiology, diabetes, and pain management, showcase RPM's capacity to deliver automated, data-driven care, thereby reducing healthcare burdens while enhancing patient outcomes and quality of life.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"4223-4237"},"PeriodicalIF":2.5,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Mechanosensitive Piezo Channels in Chronic Pain.","authors":"Yantong Wan, Jieshu Zhou, Hao Li","doi":"10.2147/JPR.S490459","DOIUrl":"10.2147/JPR.S490459","url":null,"abstract":"<p><strong>Purpose of review: </strong>Mechanosensitive Piezo channels are ion channels activated by mechanical stimuli, playing a crucial role in mechanotransduction processes and mechanical hypersensitivity. When these channels are subjected to mechanical loading, membrane currents rise instantaneously, depolarizing and activating voltage-gated calcium channels. This results in an increase in intracellular Ca²⁺, which contributes to heightened sensitivity to mechanical stimuli. This review delves into the characteristics and mechanisms of Piezo channels in chronic pain.</p><p><strong>Recent findings: </strong>The findings suggest that Piezo channels are integral to the occurrence and development of chronic pain, including neuropathic pain, visceral pain, musculoskeletal pain, headache or orofacial pain, and inflammatory pain. Piezo channels significantly impact pain perception and transmission. These channels' critical involvement in various pain types highlights their potential as promising targets for chronic pain therapy.</p><p><strong>Summary: </strong>This review discusses the role of Piezo channels in chronic pain. By understanding these pain mechanisms, new therapeutic strategies can be developed to alleviate chronic pain, offering hope for patients suffering from these debilitating conditions.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"4199-4212"},"PeriodicalIF":2.5,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Acupoint Selection and Combinations in Acupuncture Treatment of Migraine: A Protocol for Data Mining.","authors":"Yujun He, Yachao Wu, Xiaojun Li","doi":"10.2147/JPR.S489296","DOIUrl":"10.2147/JPR.S489296","url":null,"abstract":"<p><strong>Background: </strong>Migraine is a prevalent neurological condition that causes significant disability and has a profound impact on sufferers' ability to work and their overall quality of life. The efficacy of acupuncture in the treatment of migraines has been confirmed via extensive clinical research. However, because each acupoint generates various analgesic processes, and different acupuncture physicians select different acupoints, there is still uncertainty regarding the optimal acupoint selection.</p><p><strong>Objective: </strong>Our purpose is to conduct the initial thorough data mining analysis to determine the optimal acupoint selection and combinations for the treatment of migraines.</p><p><strong>Methods: </strong>We will conduct a search of eight electronic bibliographic databases (PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Database, Chinese Biomedical Literature Database, and Chongqing VIP Database) from the inception of the databases to July 2024. Clinical trials that evaluate the efficacy of acupuncture therapy in migraine management will be chosen. Literature will be rigorously reviewed in accordance with inclusion and exclusion criteria, and pertinent data will be extracted for analysis. Excel 2021 will be utilized to conduct descriptive statistics. SPSS Modeler 14.1 will be employed to conduct the association rule analysis. SPSS Statistics 26.0 will be employed to conduct exploratory factor analysis, cluster analysis, and decision tree analysis.</p><p><strong>Results: </strong>This study aims to investigate the optimal acupoint selection and combinations for people suffering from migraines.</p><p><strong>Conclusion: </strong>Our research will offer empirical support for the efficacy and possible therapeutic recommendations of acupoint application in treating migraine patients, facilitating collaborative decision-making between physicians and patients.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"4149-4157"},"PeriodicalIF":2.5,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of Botulinum Toxin Use in Service Members and Veterans with Migraine and Post-Traumatic Headache Disorders: A Scoping Review.","authors":"Qing Zhao Ruan, Daniel J Pak, David E Reece, Rohan Jotwani, Sean Li, Moises Dominguez, Alan David Kaye, R Jason Yong, Abdulrazaq Albilali, Sadiq Bhayani, Jamal Hasoon, Michael E Schatman, Jun Beom Ku, Thomas T Simopoulos, Sait Ashina, Christopher L Robinson","doi":"10.2147/JPR.S487712","DOIUrl":"10.2147/JPR.S487712","url":null,"abstract":"<p><strong>Objective: </strong>To delineate the trend of use of botulinum toxin, including onabotulinum toxinA (OTA), in active military personnel and veterans with the diagnoses of migraine and post-traumatic headache (PTH) and describe the efficacy of botulinum toxin administration.</p><p><strong>Background: </strong>Service members and veterans represent a unique population in the medical management of headache disorders, particularly migraine. They exhibit higher susceptibility to pain of greater intensity and longer durations, possibly due to their history of exposure to combat, trauma, and the associated psychological stresses. Given the burden and morbid nature of these headache disorders, prophylactic measures to reduce migraine attacks and disability are imperative. Specifically, the use of OTA for migraine prophylaxis has been well validated in chronic migraine.</p><p><strong>Methods: </strong>The scoping review conformed to guidelines delineated by Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). The databases Medline, Embase, and Google Scholar were accessed for our literature search, and the time frame of the search was set from database inception to April 1, 2024.</p><p><strong>Results: </strong>A total of 8 articles meeting the inclusion criteria were obtained after screening a total of 43 papers. Studies were primarily conducted in the United States (87.5%), with a single article published on veterans from Taiwan. Study types were mainly retrospective chart reviews with the exception of 2 randomized controlled trials. Chronic migraine was the most common headache diagnosis examined, being assessed in 6 studies, followed by PTH, which was represented in the remaining 2 studies.</p><p><strong>Conclusion: </strong>The occupational exposure of service members appears to result in a higher incidence of headache disorders such as chronic migraine and PTH, which are amenable to preventative management such as that with botulinum toxin. Despite its effectiveness, the use of botulinum toxin in treating headaches and craniofacial pain in service members remains under-researched, warranting further exploration in this population, specifically.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"4177-4186"},"PeriodicalIF":2.5,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Commentary on \"Pain Reduction and Improved Vascular Health Associated with Daily Consumption of an Anti-Inflammatory Dietary Supplement Blend\" [Letter].","authors":"Aili Fang, Yuxuan Miao, Han Wang","doi":"10.2147/JPR.S507795","DOIUrl":"10.2147/JPR.S507795","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"17 ","pages":"4197-4198"},"PeriodicalIF":2.5,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}