纤维肌痛患者脑连通性改变的脑白质功能和结构联合成像。

IF 2.5 3区 医学 Q2 CLINICAL NEUROLOGY
Journal of Pain Research Pub Date : 2025-07-03 eCollection Date: 2025-01-01 DOI:10.2147/JPR.S512581
Ziyi Gao, Xinyan Xie, Fuyuan Liu, Tong Xu, Nan Zhang, Xinran Zhang, Yun Li, Youyong Kong, Dongling Lv, Ting Wu
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引用次数: 0

摘要

背景:纤维肌痛综合征(FMS)是一种常见的中枢性慢性疼痛疾病,病理生理机制尚不清楚。白质(WM)在脑信号传递中起着至关重要的作用,FMS中白质结构异常已被报道。然而,FMS患者的功能性WM变化尚未被研究。本研究旨在探讨WM的功能性神经变化是否伴随FMS观察到的结构变化。方法:选取FMS患者43例,健康对照43例。分别采用分数各向异性(FA)和低频波动幅度(ALFF)对WM进行结构和功能分析,以探讨FMS患者WM的变化。结果:结构分析显示FMS患者左侧皮质脊髓束(CST)、右侧扣带/海马、右侧穹窿/终纹(FX/ST)、枕额上束(SOFF)、右侧上放射冠(SCR)、右侧后放射冠(PCR)、矢状层和左侧内侧小网膜(ML) FA值发生改变。在静息状态下,部分结构改变的区域也表现出功能激活的变化。功能分析显示,FMS患者左侧CST、左侧ML、右侧PCR、右侧扣带/海马和右侧FX/ST的ALFF值降低。此外,右侧扣带/海马体和左侧ML中ALFF的减少程度与焦虑、抑郁和疼痛严重程度评分呈正相关。结论:本研究从WM功能信号的角度对FMS的机制进行了初步探索。观察到的WM功能激活的减少为FMS的病理生理学提供了新的见解,并突出了以WM为重点的治疗策略的潜在目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Combined Functional and Structural Imaging of White Matter Reveals Brain Connectivity Alterations in Fibromyalgia Patients.

Background: Fibromyalgia syndrome (FMS) is a prevalent central chronic pain condition of unknown pathophysiology. White matter (WM) plays a crucial role in brain signal transmission, and WM structural abnormalities have been reported in FMS. However, functional WM changes in FMS patients have not been investigated. This study aimed to investigate whether functional neural changes in WM accompany structural changes observed in FMS.

Methods: The study included 43 FMS patients and 43 healthy controls. Structural and functional analyses of WM were assessed using fractional anisotropy (FA) and amplitude of low-frequency fluctuation (ALFF), respectively, to explore WM alterations in FMS patients.

Results: Structural analysis revealed altered FA values in the left corticospinal tract (CST), right cingulate/hippocampus, right fornix/stria terminalis (FX/ST), superior occipitofrontal fasciculus (SOFF), right superior corona radiata (SCR), right posterior corona radiata (PCR), sagittal stratum, and left medial lemniscus (ML) in FMS patients. Some regions showing structural changes also showed changes in resting-state functional activation. Functional analysis showed that FMS patients have reduced ALFF values in the left CST, left ML, right PCR, right cingulate/hippocampus, and right FX/ST. Furthermore, the degree of ALFF reduction in the right cingulate/hippocampus and left ML was positively correlated with anxiety, depression, and pain severity scores.

Conclusion: This study provides a preliminary exploration of the mechanisms underlying FMS in terms of WM functional signals. The observed reduction in WM functional activation offers novel insights into the pathophysiology of FMS and highlights potential targets for WM-focused therapeutic strategies.

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来源期刊
Journal of Pain Research
Journal of Pain Research CLINICAL NEUROLOGY-
CiteScore
4.50
自引率
3.70%
发文量
411
审稿时长
16 weeks
期刊介绍: Journal of Pain Research is an international, peer-reviewed, open access journal that welcomes laboratory and clinical findings in the fields of pain research and the prevention and management of pain. Original research, reviews, symposium reports, hypothesis formation and commentaries are all considered for publication. Additionally, the journal now welcomes the submission of pain-policy-related editorials and commentaries, particularly in regard to ethical, regulatory, forensic, and other legal issues in pain medicine, and to the education of pain practitioners and researchers.
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