Journal of Pain Research最新文献

{"title":"A Real-World Study of Cetylated Fatty Acids Food Supplement Administration in Italian Adults for Sub-Acute or Chronic Musculoskeletal Pain.","authors":"Rosaria Lanzisera, Fabrizio Gervasoni, Maria Sole Rossato, Germano Tarantino, Antonella Lo Mauro, Elisabetta Geri","doi":"10.2147/JPR.S511708","DOIUrl":"10.2147/JPR.S511708","url":null,"abstract":"<p><strong>Purpose: </strong>This real-world observational study was conducted to evaluate decrease in pain after 30-day administration of a new oral cetylated fatty acids (CFA) food supplement, assess if decreased pain resulted in a lower consumption of oral non-steroidal anti-inflammatory drugs (NSAIDs), and improvement in related gastric side effects. It was the first study of this food supplement in a real-world setting.</p><p><strong>Patients and methods: </strong>A hundred and twenty Italian primary care physicians recruited 562 patients who were prescribed oral CFA. Patients completed the Brief Pain Inventory (BPI) questionnaire at baseline and after 30 days of dosing. Their CFA intake adherence and use of NSAIDs were recorded. All analyses were done using R statistical software; p-value ≤ 0.005 was considered statistically significant.</p><p><strong>Results: </strong>We analyzed data of 196 males and 366 females aged in an average 49.2 years. After 30 days of CFA intake, we observed a statistically significant reduction (38.84%) in the overall pain score, 44.53% reduction in the interference score in daily activities, relief from pain within the previous 24 hours 47.16 (± 11.44%) at baseline and 62.14 (± 27.93%) after 30 days, and progressive reduction in NSAID intake frequency and total dose over time. More than half of participants (55.2%) reported improvement in gastric side effects typically associated with NSAID use.</p><p><strong>Conclusion: </strong>Data analyses indicated that using the new oral CFA food supplement decreased pain, which helped improve the quality of life, better perform daily activities (interference reduced by 44.5%), and reduce painkiller consumption by 19.7% in terms of both dose and frequency. Half of participants (55.2%) rated NSAID-related hyperchlorhydria and heartburn as improved. Although placebo effect might have contributed, the results suggest that CFA may have a positive effect in patients with sub-acute and chronic musculoskeletal pain and can enhance therapies typically used in this population.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2751-2760"},"PeriodicalIF":2.5,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12132066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Interaction Mechanisms of Antibody-Mediated Immune Responses with Gout and Rheumatoid Arthritis Through a Bidirectional Two-Sample Mendelian Randomization Study.","authors":"Hanyu Zhou, Qiaolin Liu, Duanbo Lv, Yinghao Zheng, Zhenlong Xing","doi":"10.2147/JPR.S508813","DOIUrl":"10.2147/JPR.S508813","url":null,"abstract":"<p><strong>Purpose: </strong>Gout and Rheumatoid arthritis (RA) are two prevalent non-infectious inflammatory joint diseases that can occur independently or concurrently. The effects and mechanisms related to antibody-mediated immune responses and both Gout and RA remain unclear. The research seeks to investigate the potential causal association and offer a novel perspective for their prevention and treatment strategies.</p><p><strong>Methods: </strong>The study employed the bidirectional two-sample Mendelian randomization (MR) analysis for investigation. Datasets comprising 46 antibody-mediated immune responses, as well as those for Gout and RA, were curated from published genome-wide association studies (GWAS). For the causality analysis, methods such as Inverse Variance Weighted (IVW), Weighted Median, Simple Mode, MR-Egger, and Weighted Mode were utilized. We chose MR pleiotropy residual sum and outlier (MR-PRESSO), IVW, MR-Egger, and Leave-one-out for sensitivity analysis to enhance the reliability of the results.</p><p><strong>Results: </strong>We meticulously excluded the results that exhibited pleiotropy and instability. Finally, four antibody-mediated immune responses have been found as causal factors in the development of Gout: Anti-chlamydia trachomatis IgG seropositivity, Anti-human herpes virus 6 IE1B IgG seropositivity, Helicobacter pylori GroEL antibody levels, and Polyomavirus 2 JC VP1 antibody levels; Two antibody-mediated immune responses influence RA causally: BK polyomavirus VP1 antibody levels, and Helicobacter pylori Catalase antibody levels. In the reverse analysis, three antibody-mediated immune responses could be influenced by Gout: BK polyomavirus VP1 antibody levels, Chlamydia trachomatis tarp-D F2 antibody levels, and Varicella zoster virus glycoproteins E and I antibody levels; Two antibody-mediated immune responses could be causally affected by RA: Anti-human herpes virus 7 IgG seropositivity, and Merkel cell polyomavirus VP1 antibody levels.</p><p><strong>Conclusion: </strong>The research indicated that antibody-mediated immune responses establish a causal link with this two non-infectious inflammatory joint diseases: Gout and RA, offering new avenues and perspectives for the future prophylaxis and treatment of diseases from an immunological standpoint.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2707-2738"},"PeriodicalIF":2.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12127211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing the Optimal Diversity Training Programs for Physicians: A Survey sponsored by Pacific Spine and Pain Society.","authors":"Julian L Gendreau, Megan M J Bauman, Nolan J Brown, Melanie Alfonzo Horowitz, Sachiv Chakravarti, Yusuf Mehkri, Brittany Grovey, Eric Lee, Gemayel Lee, Eric Cornidez, Harjot S Bhandal, Jason E Pope","doi":"10.2147/JPR.S512263","DOIUrl":"10.2147/JPR.S512263","url":null,"abstract":"<p><strong>Introduction: </strong>Recently, increasing research has shown inferior outcomes in patients with respect to specific social determinants of health. Therefore, optimizing diversity training given to pain management providers is imperative for physicians to provide culturally competent healthcare and to improve patient outcomes. In this paper, we attempt to describe trends in the Pacific Spine and Pain Society (PSPS) membership to help discover optimal diversity education paradigms for pain management providers by performing a survey on behalf PSPS.</p><p><strong>Methods: </strong>A survey was disseminated to all members of the PSPS at the 2022 annual meeting. Opinions were solicited with respect to respondents' demographics, diversity training type, diversity training timing, and how this correlates with a respondent's self-reported confidence in navigating diversity issues in the workplace. Cronbach's alpha test was used to rate internal consistency while logistic regression models were used for statistical analysis.</p><p><strong>Results: </strong>Cronbach's alpha produced a rating of 0.91. A total of 164 individuals responded to the survey, with 115 (70%) being male and 98 (60%) did not consider themselves to be under-represented in medicine. Survey respondents who obtained diversity training post-fellowship (p = 0.004) and with interactive training type (p = 0.010) self-reported to be more confident in handling matters of diversity in the workplace. Respondents who were underrepresented (p = 0.018), females (p = 0.033), practice in the west coast (p = 0.036), academic practice (p=0.031), and non-rural areas (p = 0.033) were also found to be more confident in handling matters of diversity.</p><p><strong>Conclusion: </strong>Practitioners who received diversity training post-fellowship and with interactive and role model formats felt most confident to handle matters of diversity. Underrepresented groups, females, individuals from non-rural practices and individuals from academic practices appear to feel more confident in handling these issues.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2739-2750"},"PeriodicalIF":2.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Efficacy of Single- <i>vs</i> Dual-Level Transversus Abdominis Plane Block for Lower Segment Cesarean Section: A Prospective, Randomized, Controlled Study.","authors":"Wan-Na Cao, Bei Qiu, Ying Li, Chang-Long Hu, Hua-Cheng Liu, Kai-Ming Yuan, Fang-Yi Wang","doi":"10.2147/JPR.S520944","DOIUrl":"10.2147/JPR.S520944","url":null,"abstract":"<p><strong>Objective: </strong>Transversus abdominis plane block (TAPB) has been widely used for lower-segment cesarean sections (CS). However, traditional single-level TAPB may not provide sufficient analgesia for parturients. This study aimed to validate whether dual-level TAPB could offer more extensive blocking and better clinical outcomes.</p><p><strong>Methods: </strong>A total of 114 full-term parturients undergoing lower-segment CS were included in this prospective, randomized, controlled study. Subjects were randomly assigned to receive either single-level (group SL) or dual-level (group DL) TAPB. Dual-level TAPB was performed at the umbilical level and the level above the anterior superior iliac spine, while single-level was performed only at the umbilical level. The primary outcome was the proportion of the abdomen successfully blocked 20 minutes after TAPB.</p><p><strong>Results: </strong>Twenty minutes after TAPB, dual-level TAPB resulted in a more extensive cutaneous sensory block compared to single-level TAPB. The difference in the proportion of successfully blocked zones was statistically significant, with 46.9% (43.8%, 53.1%) in group SL <i>versus</i> 71.9% (62.5%, 75.0%) in group DL, <i>p</i> < 0.001. Notably, the proportion of parturients with the \"surgical area\" completely blocked was significantly higher in group DL (94.7%) than in group SL (82.5%) (<i>p</i> = 0.039). Compared to Group SL, the first request for postoperative analgesia was delayed in Group DL by 2.5 hours.</p><p><strong>Conclusion: </strong>Compared to traditional single-level TAPB, dual-level TAPB produced more extensive cutaneous sensory block and better postoperative analgesia effects.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2689-2698"},"PeriodicalIF":2.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Effects of Interventional Pain Management Staff Controlled Substance Agreement Education for Patients with Chronic Non-Cancer Intrathecal Drug Delivery Device Opioid Therapy: A Retrospective Review.","authors":"Chelsey Hoffmann, Trina McDonald, Becky Gladis, Michael E Schatman, Thomas P Pittelkow","doi":"10.2147/JPR.S521458","DOIUrl":"10.2147/JPR.S521458","url":null,"abstract":"<p><strong>Background: </strong>Intrathecal drug delivery systems (IDDS) are effective tools for the management of chronic non-cancer pain, cancer-associated pain, and spasticity. Given the overall risks of opioid medications, it is imperative that IDDS opioid-infusion patients receive education regarding the risks versus benefits of their intrathecal opioid medications and that controlled substance agreements (CSAs) are utilized to both educate patients and hold them accountable for keeping IDDS programming visits, refill appointments, or other IDDS maintenance appointments.</p><p><strong>Methods: </strong>A retrospective electronic medical record (EMR) review study was conducted at an interventional pain management practice, quantifying the number of non-cancer chronic pain IDDS opioid therapy patients with signed CSAs. An educational intervention was conducted to increase staff awareness regarding compliance with CSAs and the location of proper CSA documentation within the EMR. Follow-up EMR review and provider knowledge assessment surveys were deployed to assess the success of the intervention.</p><p><strong>Results: </strong>Staff knowledge of CSAs increased from 14.3% (3/21) to 45.5% (10/22) following CSA education while their ability to locate CSAs within the EMR also increased from 38.1% (8/21) to 40.9% (9/22). Post-education intervention, rates of CSA documentation improved from 4.5% to 74.5%. Lastly, there was a 39.5% reduction in rescheduled IDDS appointments within the patient population studied.</p><p><strong>Conclusion: </strong>The results of this study suggest potentially profound impacts that a simple education intervention can have on staff knowledge and compliance with CSA documentation for patients receiving IDDS opioid therapy for chronic non-cancer pain. Furthermore, implementation of CSAs for this patient population may be associated with a decrease in the number of missed, no-show, or rescheduled IDDS maintenance appointments, which have important patient safety implications. Further research is warranted to investigate the impact of CSA compliance on adverse patient outcomes and the potential cost-savings practices with required CSAs.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2699-2706"},"PeriodicalIF":2.5,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12124305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144199436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Transcutaneous Electrical Acustimulation on Patients with Fibromyalgia Syndrome: Study Protocol of a Randomized, Double-Blind, Sham-Controlled Trial.","authors":"Yanpi Li, Bifa Fan, Xiyun Wang, Naichong Hu, Xinyi Zhou, Yi Zhang, Peng Mao, Yifan Li","doi":"10.2147/JPR.S523538","DOIUrl":"10.2147/JPR.S523538","url":null,"abstract":"<p><strong>Background: </strong>Fibromyalgia Syndrome (FMS) is a chronic disorder characterized by widespread musculoskeletal pain, fatigue, and localized tenderness. Transcutaneous Electrical Acustimulation (TEA) is a non-invasive therapy that combines Traditional Chinese Medicine with electrical stimulation at specific acupoints. Previous studies have shown that TEA is effective in treating pain-related conditions. This study aims to evaluate the efficacy and mechanisms of TEA treatment for FMS.</p><p><strong>Design: </strong>This is a prospective, randomized, double-blind, and placebo-controlled trial with two parallel groups, conducted at a single center. Forty participants will be randomly assigned to either the TEA group or the sham-TEA group in a 1:1 ratio. Participants will receive 2 weeks of treatment followed by 2 weeks of follow-up. The primary outcome is the change in VAS pain scores before and after treatment. Secondary outcomes include FMS and pain-related questionnaire scales, infrared thermography (IRT), vibration-controlled transient elastography (VCTE), blood neurobiological markers, cytokines, and metabolomics.</p><p><strong>Trial registration: </strong>http://itmctr.ccebtcm.org.cn/ identifier ITMCTR2024000638.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2663-2677"},"PeriodicalIF":2.5,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Pericapsular Nerve Group Block with Wound Infiltration vs Modified Supra-Inguinal Fascia Iliaca Block on Postoperative Analgesia in Adult Patients Undergoing Total Hip Arthroplasty - A Randomized Clinical Trial.","authors":"Ying Huang, Sheng Peng, Jun Wang, Lang Liu, Chun-Shan Dong","doi":"10.2147/JPR.S517578","DOIUrl":"10.2147/JPR.S517578","url":null,"abstract":"<p><strong>Purpose: </strong>Pericapsular nerve group (PENG) block and supra-inguinal fascia iliaca block (S-FICB) provides incomplete analgesia for total hip arthroplasty (THA) due to anatomical limitations. This study compares two modified approaches-PENG block with wound infiltration (WI) and a modified S-FICB-to identify the optimal analgesic technique for THA.</p><p><strong>Patients and methods: </strong>Eighty-six subjects were randomly allocated to either the PENG block + WI group or the modified S-FICB group. The primary outcome was the postoperative numeric rating scale (NRS) pain scores (rest/hip adduction) at 6 hours. The secondary outcomes were pain scores at 12, 24, 48 hours postoperatively and postoperative day 5, the incidence of postoperative quadriceps motor block at 6, 12, 24, 48 hours and postoperative day 5, the mean blood pressure (MAP) at five time points, patient-controlled intravenous analgesia (PCIA) usage and adverse effects such as the incidence of rescue analgesia, local anesthetic systemic toxicity (LAST), postoperative hip infection, the incidence of postoperative nausea and vomiting (PONV) within 5 days after surgery.</p><p><strong>Results: </strong>PENG + WI group had lower NRS at rest (6h) (95% CI 0.51-1.64, p<0.001). Compared with the PENG block + WI, the modified S-FICB resulted in a higher incidence of quadriceps motor block at 6 hours (82.1% vs 25.6%; OR=13.257, 95% CI 4.46-39.38; p<0.001) and 12 hours (71.8% vs 41%; OR=3.659, 95% CI 1.42-9.42; p=0.001).</p><p><strong>Conclusion: </strong>PENG block + WI provides sufficient postoperative analgesia with no quadriceps motor block compared to modified S-FICB, supporting early ambulation and in line with the enhanced recovery after surgery (ERAS) protocols.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2679-2688"},"PeriodicalIF":2.5,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Do Doctors and Patients Have Different Understandings of Pain?\" - A Pilot Study of Different Perspectives and Understandings of Pain in Clinical Pain Research.","authors":"Lise Kirstine Gormsen","doi":"10.2147/JPR.S508125","DOIUrl":"10.2147/JPR.S508125","url":null,"abstract":"<p><strong>Background and objective: </strong>Ambiguous results on pain thresholds often occur from biomedical pain research. Although results and methods are frequently discussed, only few studies have investigated participants' understanding and perspectives of pain in research settings. The aim of this qualitative pilot study was to explore different understandings of pain in a clinical pain research setting.</p><p><strong>Methods: </strong>We briefly interviewed 25 subjects, including Danish pain doctors and psychiatrists as well as pain patients, depressed patients, and healthy controls (five in each group) about their understanding of pain.</p><p><strong>Results: </strong>Laymen seem less inclined to verbalize pain than professionals. In addition, they may embrace a concept of suffering that goes beyond the traditional body-mind dichotomy. Since suffering may be part of the pain experience, this difference in the understanding of pain may be at the core of the often ambiguous results when doctors and other health professionals study pain.</p><p><strong>Conclusion: </strong>The results emphasize the need for supporting the ongoing process of integrating broad perspectives on pain in clinical pain research, including the concept of suffering. More research and resources are needed in this particular area of pain medicine.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2651-2662"},"PeriodicalIF":2.5,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12120140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NMRAL1 as a Causal Factor in Postherpetic Neuralgia: A Proteome-Wide Mendelian Randomization Study.","authors":"Hong Ye, Yiling Wang, Yuechun Shi, Yuyu Wu, Qiuhan Xu, Songmin Huang","doi":"10.2147/JPR.S512034","DOIUrl":"10.2147/JPR.S512034","url":null,"abstract":"<p><strong>Background: </strong>Postherpetic neuralgia (PHN) is a chronic pain condition following herpes zoster infection, disproportionately affecting elderly and immunocompromised individuals. Despite its significant clinical impact, the underlying mechanisms of PHN remain exclusive, and effective treatments are limited. Circulating plasma proteins offer insights into PHN pathogenesis and serve as potential biomarkers or therapeutic targets.</p><p><strong>Methods: </strong>We analyzed FinnGen R12 GWAS data (490 PHN cases and 435,371 controls) and protein quantitative trait loci (pQTL) data for 4907 plasma proteins from 35,559 Icelanders. Mendelian randomization (MR) was conducted to investigate causal associations between plasma proteins and PHN risk. Causal effects were assessed using inverse variance weighting (IVW) and MR-Egger methods.</p><p><strong>Results: </strong>MR analysis identified NMRAL1 as the only plasma protein causally associated with PHN. Genetically predicted higher levels of NMRAL1 were linked to a reduced risk of PHN (IVW odds ratio = 0.553, 95% confidence interval: 0.405-0.755, p = 0.000193). No evidence of heterogeneity or pleiotropy was observed, and sensitivity analyses, including leave-one-out analysis, confirmed the robustness of the findings. No other plasma proteins showed significant associations with PHN.</p><p><strong>Conclusion: </strong>This study identifies NMRAL1 as a protective factor for PHN and underscores its potential as a biomarker and therapeutic target. The findings highlight the utility of integrating proteomic and genetic data to advance understanding of complex neurological disorders like PHN.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2623-2629"},"PeriodicalIF":2.5,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12117202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Jingjin Therapy for Non-Specific Chronic Neck Pain with Extension Dysfunction: A Randomised Controlled Trial.","authors":"Zhichao Gong, Yinyan Gao, Wenqi Liu, Wu Li, Xinyin Wu, Jiangshan Li","doi":"10.2147/JPR.S515232","DOIUrl":"10.2147/JPR.S515232","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate whether Jingjin therapy, a distal manual intervention, could accelerate extension dysfunction for non-specific chronic neck pain (NCNP).</p><p><strong>Patients and methods: </strong>In this single-centre, two-arm randomised controlled trial, we enrolled Chinese patients aged 20-60 years with active neck extension disorder, regardless of prior exposure to manual therapy. We randomly assigned 160 patients to one of the following two arms: Jingjin therapy or general manual therapy. Both groups underwent six treatment sessions: the first three sessions were administered daily, and the last three sessions were administered every other day. The primary outcome was the between-group difference in the angle of active neck extension after the sixth treatment and 1 week after treatment. A repeated-measures linear mixed-effects model was used to assess between-group differences in outcome indices, with group allocation and treatment time points treated as fixed effects and participants as random effects.</p><p><strong>Results: </strong>The change in the angle of active neck extension from baseline to the sixth treatment session was significant for Jingjin therapy (mean: 29.75° to 51.97°) and general manual therapy (mean: 28.18° to 52.49°). Further, the between-group difference was minimal (mean -0.26°, 95% confidence interval, -2.62°, 2.09°) and not statistically significant (<i>P</i> = 0.828).</p><p><strong>Conclusion: </strong>Jingjin therapy for 9 days significantly improved neck extension function in patients with NCNP, with no significant difference compared to general manual therapy.</p><p><strong>Clinical trial registry id: </strong>ChiCTR2300068892.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2631-2642"},"PeriodicalIF":2.5,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144159705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}