Journal of Pain Research最新文献

{"title":"Frailty and Incident Low Back Pain in Middle-Aged and Older Adults: Methodological Considerations [Letter].","authors":"Siqi Wang, Wei Zou","doi":"10.2147/JPR.S657433","DOIUrl":"https://doi.org/10.2147/JPR.S657433","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"657433"},"PeriodicalIF":3.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Oliceridine versus Sufentanil on the Quality of Postoperative Recovery in Patients Undergoing Laparoscopic Cholecystectomy [Response to Letter].","authors":"Li-Hao Rao, Ze-Xue Yang, Lun Huang, Li-Dong Zheng","doi":"10.2147/JPR.S638976","DOIUrl":"https://doi.org/10.2147/JPR.S638976","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"638976"},"PeriodicalIF":3.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG-Derived Pain Threshold Index-Guided Remifentanil Titration During Laparoscopic Abdominal Surgery: A Randomized Trial.","authors":"Bin Cao, Zheng Qi, Ying-Ying Zhao, Qiong Xue, Juan-Juan Ren, Wei-Wei Xu, Yu-Ning Fan, Zhen-Hua Nan, Pei-Pei Sun, Hui-Juan Li, Jie Zhang, Jian-Jun Yang","doi":"10.2147/JPR.S642801","DOIUrl":"https://doi.org/10.2147/JPR.S642801","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether remifentanil titration guided by the pain threshold index (PTi), an electroencephalography-derived proxy for nociceptive tolerance rather than subjective pain, reduces intraoperative remifentanil infusion during laparoscopic abdominal surgery.</p><p><strong>Methods: </strong>In this prospective, single-center, assessor-blinded randomized trial, adults undergoing elective laparoscopic abdominal surgery with propofol-remifentanil target-controlled infusion were assigned 1:1 to PTi-guided or conventional hemodynamic-guided remifentanil titration. The primary endpoint was intraoperative remifentanil infusion rate. The principal analysis used the full-analysis set and covariate-adjusted linear regression with heteroskedasticity-consistent robust standard errors.</p><p><strong>Results: </strong>Among 200 randomized patients, 195 were analyzed (98 PTi-guided; 97 control). The primary endpoint was neutral: mean (SD) remifentanil infusion rate was 7.44 (1.43) versus 7.63 (1.41) µg kg^-1 h^-1; adjusted mean difference, -0.06 µg kg^-1 h^-1 (95% CI, -0.44 to 0.32; P=0.758). Per-protocol results were similar. Median (IQR) NRS at post-anesthesia care unit (PACU) admission was 2.0 (2.0-3.0) versus 3.0 (2.0-4.0), and Ramsay score was 2.0 (2.0-2.0) in both groups. In exploratory secondary analyses, rescue opioid was used in the PACU by 18/98 (18.4%) versus 31/97 (32.0%) patients and any rescue opioid through 48 h by 29/98 (29.6%) versus 44/97 (45.4%). Any postoperative nausea and vomiting (PONV) through 48 h occurred in 17/98 (17.3%) versus 29/97 (29.9%) patients. Total postoperative opioid exposure through 48 h was not reduced.</p><p><strong>Conclusion: </strong>PTi-guided remifentanil titration did not reduce intraoperative remifentanil infusion. PACU pain and sedation scores were not materially different. Lower early rescue-opioid use and fewer PONV events through 48 h were exploratory secondary findings, were not accompanied by lower postoperative opioid dose, and require prospective confirmation.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"642801"},"PeriodicalIF":3.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Warm-Needling Acupuncture Plus Tuina for Knee Osteoarthritis: Considerations Regarding Effect Estimates, Comparator Design, and Assay Standardization [Letter].","authors":"Keqin Ye","doi":"10.2147/JPR.S659186","DOIUrl":"https://doi.org/10.2147/JPR.S659186","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"659186"},"PeriodicalIF":3.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture-Associated Changes in Migraine-Like Behaviors and Serum Proteomic and Metabolomic Profiles in Nitroglycerin-Induced Rats.","authors":"Shijie Wei, Huafeng Cui, Zhe Wang, Guoliang Jiang, Xiaowei Hu, Qianxiu Chen, Yihang Xu, Jing Han","doi":"10.2147/JPR.S632901","DOIUrl":"https://doi.org/10.2147/JPR.S632901","url":null,"abstract":"<p><strong>Purpose: </strong>Acupuncture is widely used as a therapeutic approach for migraine; however, its underlying anti-migraine mechanisms remain incompletely understood. This study aimed to investigate the therapeutic effects of acupuncture on migraine and identify potential molecular mechanisms using integrated multi-omics analyses.</p><p><strong>Patients and methods: </strong>32 male Sprague-Dawley rats were allocated to control, model, sham-acupuncture, and acupuncture groups (n = 8 per group). The model was established by repeated nitroglycerin (NTG) administration. The effects of acupuncture were evaluated by assessing periorbital and hind paw withdrawal thresholds. Serum samples were subsequently analyzed using liquid chromatography-mass spectrometry (LC-MS)-based metabolomics and proteomics. The mRNA levels of key targets in serum were further quantified using quantitative reverse transcription polymerase chain reaction (qRT-PCR). Differential metabolites and proteins were identified and subjected to Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, correlation, and protein-protein interaction (PPI) analyses.</p><p><strong>Results: </strong>Acupuncture alleviated the reduction in periorbital and hind paw withdrawal thresholds in NTG-induced migraine model rats. Integrated metabolomic and proteomic analyses identified differential metabolites and proteins associated with the therapeutic effects of acupuncture. Ten candidate hub proteins were ultimately identified. KEGG enrichment analysis indicated that these candidate hub proteins were closely related to immune defense, inflammatory responses, cholesterol metabolism and clearance, and may also be involved in energy metabolism and hormonal regulation. GO analysis further showed that acupuncture primarily modulated biological processes related to lipoprotein metabolism, transport, and clearance.</p><p><strong>Conclusion: </strong>Acupuncture improved migraine-like mechanical hypersensitivity in NTG-induced rats and was accompanied by changes in serum proteins and metabolites. Lipid/lipoprotein metabolism and complement-related pathways emerged as candidate pathways associated with the response. These exploratory findings do not establish molecular mediation or a direct effect on vascular function and require confirmation by targeted functional studies.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"632901"},"PeriodicalIF":3.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic Neuropathic Pain Models: Current Limitations and Future Directions.","authors":"Lijun Hao","doi":"10.2147/JPR.S632056","DOIUrl":"https://doi.org/10.2147/JPR.S632056","url":null,"abstract":"<p><p>Diabetic neuropathic pain (DNP) is a disabling complication of diabetes, yet pain develops only in a subset of patients with diabetic neuropathy. Current animal models can reproduce hyperglycemia and many structural, electrophysiological, and metabolic features of diabetic neuropathy, but pain-related phenotypes vary considerably across studies. This variability may arise from methodological differences in model induction, experimental conditions, and behavioral assessment, but may also reflect biologically meaningful heterogeneity analogous to the painful and painless phenotypes observed clinically. This narrative review critically examines the strengths and limitations of commonly used streptozotocin (STZ), genetic, and high-fat diet/STZ models, with particular attention to variability in pain-related phenotypes and its implications for model interpretation. Species, strain, sex, disease duration, metabolic severity, model induction, and behavioral methodology may all contribute to differences among studies. On the basis of this synthesis, we suggest that future studies distinguish methodological variability from biological heterogeneity and use more consistent reporting, longitudinal assessment, and complementary measures of neuropathy to improve interpretation and clinical relevance.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"632056"},"PeriodicalIF":3.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13654264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concerns Regarding Evidence for the AMPK/PGC-1α/Mfn2 Axis and Mitochondria-ER Dysfunction in a Rat Model of Myofascial Trigger Points [Letter].","authors":"Lin Chen, Xi Guo","doi":"10.2147/JPR.S659447","DOIUrl":"https://doi.org/10.2147/JPR.S659447","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"659447"},"PeriodicalIF":3.1,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Registration and Completer-Only Analysis Limit Confirmatory Claims of SRAM Superiority in Cervical Spondylosis [Letter].","authors":"Jin Yan, Panqi Yang, Boyan Su","doi":"10.2147/JPR.S651478","DOIUrl":"https://doi.org/10.2147/JPR.S651478","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"651478"},"PeriodicalIF":3.1,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of the AMPK/PGC-1α/Mfn2 Axis is Associated with Mitochondria-Endoplasmic Reticulum Dysfunction and Ultrastructural Remodeling in a Rat Model of Myofascial Trigger Points [Letter].","authors":"Binghao Wang, Shuang Wu, Zhen Liu, Lijiang Lv, Zhizhen Lv","doi":"10.2147/JPR.S657183","DOIUrl":"https://doi.org/10.2147/JPR.S657183","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"657183"},"PeriodicalIF":3.1,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Effects of Different Electroacupuncture Frequencies in Young Adults with Chronic Neck Pain: A Randomized Controlled Trial\" [Letter].","authors":"Tairu Ren, Lihua Xuan","doi":"10.2147/JPR.S660813","DOIUrl":"https://doi.org/10.2147/JPR.S660813","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"660813"},"PeriodicalIF":3.1,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}