Journal of Pain Research最新文献

{"title":"The Causal Effects Between Circulating Inflammatory Proteins and Osteoarthritis: A Mendelian Randomization and Transcriptomic Analysis.","authors":"Shaoru Lin, Changwu Wu, Yimin Pan","doi":"10.2147/JPR.S523677","DOIUrl":"10.2147/JPR.S523677","url":null,"abstract":"<p><strong>Background: </strong>Observational studies have demonstrated the correlation between various inflammatory proteins and osteoarthritis (OA). However, the causal relationship and directionality between them are still unclear. This study aims to analyze the potential causal relationship between circulating inflammatory proteins and OA using Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>This study used bidirectional two-sample MR analysis, employing the inverse variance-weighted as the primary MR method. The GWAS summary data for OA were derived from The Musculoskeletal Knowledge Portal, while the GWAS summary data for 91 circulating inflammatory proteins were obtained from a recently published study. Furthermore, this study used two transcriptomic cohorts from the GEO database to explore differentially expressed inflammation-related genes (IRGs) in OA and identify key inflammatory markers.</p><p><strong>Results: </strong>This study provides suggestive evidence. The forward two-sample MR analysis found that the levels of urokinase-type plasminogen activator, adenosine deaminase, C-C motif chemokine 19, interleukin-10 receptor subunit alpha and latency-associated peptide transforming growth factor beta 1 have causal effects on lower risk of OA, and the levels of fractalkine, C-X-C motif chemokine 1, hepatocyte growth factor and interleukin-8 have causal effects on higher risk of OA. Reverse two-sample MR analysis showed that hip OA has causal effects on the increased levels of caspase 8, protein S100A12, interleukin-10 receptor subunit alpha, interleukin-7 and monocyte chemoattractant protein 2 and a causal effect on the decreased level of fms-related tyrosine kinase 3 ligand. Knee OA has a causal effect on the increased level of monocyte chemoattractant protein-3 and decreased level of interleukin-1-alpha respectively. Furthermore, we identified six key OA-related IRGs through comprehensive transcriptomic analysis, which could serve as potential diagnostic biomarkers for OA.</p><p><strong>Conclusion: </strong>This study supports the causal relationship between OA and specific circulating inflammatory proteins and develops potential OA-related inflammatory biomarkers.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3383-3402"},"PeriodicalIF":2.5,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Functional and Structural Imaging of White Matter Reveals Brain Connectivity Alterations in Fibromyalgia Patients.","authors":"Ziyi Gao, Xinyan Xie, Fuyuan Liu, Tong Xu, Nan Zhang, Xinran Zhang, Yun Li, Youyong Kong, Dongling Lv, Ting Wu","doi":"10.2147/JPR.S512581","DOIUrl":"10.2147/JPR.S512581","url":null,"abstract":"<p><strong>Background: </strong>Fibromyalgia syndrome (FMS) is a prevalent central chronic pain condition of unknown pathophysiology. White matter (WM) plays a crucial role in brain signal transmission, and WM structural abnormalities have been reported in FMS. However, functional WM changes in FMS patients have not been investigated. This study aimed to investigate whether functional neural changes in WM accompany structural changes observed in FMS.</p><p><strong>Methods: </strong>The study included 43 FMS patients and 43 healthy controls. Structural and functional analyses of WM were assessed using fractional anisotropy (FA) and amplitude of low-frequency fluctuation (ALFF), respectively, to explore WM alterations in FMS patients.</p><p><strong>Results: </strong>Structural analysis revealed altered FA values in the left corticospinal tract (CST), right cingulate/hippocampus, right fornix/stria terminalis (FX/ST), superior occipitofrontal fasciculus (SOFF), right superior corona radiata (SCR), right posterior corona radiata (PCR), sagittal stratum, and left medial lemniscus (ML) in FMS patients. Some regions showing structural changes also showed changes in resting-state functional activation. Functional analysis showed that FMS patients have reduced ALFF values in the left CST, left ML, right PCR, right cingulate/hippocampus, and right FX/ST. Furthermore, the degree of ALFF reduction in the right cingulate/hippocampus and left ML was positively correlated with anxiety, depression, and pain severity scores.</p><p><strong>Conclusion: </strong>This study provides a preliminary exploration of the mechanisms underlying FMS in terms of WM functional signals. The observed reduction in WM functional activation offers novel insights into the pathophysiology of FMS and highlights potential targets for WM-focused therapeutic strategies.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3361-3370"},"PeriodicalIF":2.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of the Application Rules and Clinical Significance of Acupoints in Acupuncture Treatment of Migraine Based on Data Mining [Letter].","authors":"Zhe Shen, Chuanlong Zhou, Xianming Lin","doi":"10.2147/JPR.S548954","DOIUrl":"10.2147/JPR.S548954","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3359-3360"},"PeriodicalIF":2.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Commentary on Efficacy of Acupuncture and Pharmacotherapy for Migraine Prophylaxis: A Systematic Review and Meta-Analysis [Letter].","authors":"Luyao Fu, Zhuoyi Li, Ruijie Ma","doi":"10.2147/JPR.S547779","DOIUrl":"10.2147/JPR.S547779","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3371-3372"},"PeriodicalIF":2.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Acupoint Selection and Combinations in Acupuncture Treatment of Trigeminal Neuralgia: A Protocol for Data Mining.","authors":"Yujun He, Lu Li, Miao Zhou, Yi Xu, Jie Tang, Yachao Wu, Minhui Liu, Bowen Xing, Xiaojun Li, Xiaoyi Wang","doi":"10.2147/JPR.S533617","DOIUrl":"10.2147/JPR.S533617","url":null,"abstract":"<p><strong>Background: </strong>Trigeminal neuralgia is a prevalent neurological disorder within neuropathic pain. It severely impairs patients' quality of life, disrupting daily activities with intense facial pain. While acupuncture has proven effective in treating it, there's no consensus on acupoint selection. Different acupuncturists use various acupoints based on personal theories and experiences, and the optimal acupoints remain unclear due to varied analgesic mechanisms. This lack of clarity obstructs the standardization of acupuncture treatment, emphasizing the need for further research.</p><p><strong>Objective: </strong>Our purpose is to conduct the first thorough data mining analysis to identify the most effective acupoint selection and combinations for treating trigeminal neuralgia from published clinical trials.</p><p><strong>Methods: </strong>We will search 8 electronic bibliographic databases (PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Database, Chinese Biomedical Literature Database and Chongqing VIP Database) from inception to May 2025. Clinical trials assessing the effectiveness of acupuncture therapy on the management of trigeminal neuralgia will be selected. We will strictly screen literature according to inclusion and exclusion criteria, and then extract relevant data for analysis. Descriptive statistics will be performed in Excel 2021. Association rule analysis will be performed in SPSS Modeler 14.1. Exploratory factor analysis, cluster analysis, and decision tree analysis will be performed in SPSS Statistics 26.0. Since the study was based on published studies, no ethical approval was required.</p><p><strong>Results: </strong>This study will investigate the most effective acupoint selection and combinations for patients with trigeminal neuralgia.</p><p><strong>Conclusion: </strong>Our findings will provide evidence for the effectiveness and potential treatment prescriptions of acupoint application for patients with trigeminal neuralgia, helping clinicians and patients make a more informed decision together.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3373-3381"},"PeriodicalIF":2.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous Streptozotocin Induces Variants in Painful Diabetic Peripheral Neuropathy in Female Mice.","authors":"Michelle A Hagenimana, Audrey R Green, Jessica A Tierney, Melissa E Lenert, Michael D Burton","doi":"10.2147/JPR.S523693","DOIUrl":"10.2147/JPR.S523693","url":null,"abstract":"<p><strong>Purpose: </strong>At least half of the 34 million diabetic patients in the US develop painful diabetic peripheral neuropathy (DPN). Recent evidence suggests that there are sex differences in the prevalence and mechanisms underlying pathological pain states. However, due to technical limitations in murine models, there is a dearth of the use of females in diabetic neuropathy research. There is a need to develop a reproducible model to induce painful DPN in both sexes. The predominately used model employs streptozotocin (STZ) administration via intraperitoneal injections. This strategy consistently induces diabetic pathology in males, but not females. We set out to enhance a current murine DPN model by identifying a method for inducing diabetic pathologies in male and female mice and tracking the development of painful neuropathy.</p><p><strong>Methods: </strong>Painful DPN was induced in both male and female mice through five daily intravenous injections of STZ. Metrics of diabetic pathology and pain behaviors were assessed across the development of painful DPN. To investigate neuronal sensitivity, calcium imaging assessing dorsal root ganglia neurons was performed.</p><p><strong>Results: </strong>We found that after intravenous administration of STZ, both male and female mice exhibited elevated blood glucose levels, impaired glucose tolerance, and increased mechanical and thermal hypersensitivity. Interestingly, we observed a subset of STZ-insensitive animals that displayed comparable elevated glucose levels to the STZ-sensitive animals. Calcium imaging was performed to investigate neuronal sensitivity and we found that both male and female mice with diabetic pathology had a lower latency to peak capsaicin-induced response compared to their control counterparts.</p><p><strong>Conclusion: </strong>Our findings demonstrate that intravenous administration of STZ can induce comparable diabetic neuropathy in male and female mice and opens the door for future preclinical studies on diabetic neuropathy.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3345-3357"},"PeriodicalIF":2.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12229165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Commitment to Trust and Integrity in Science: Implications for Pain and Anesthesiology Research.","authors":"Tonya M Palermo, Didier Bouhassira, Karen Deborah Davis, Hugh C Hemmings Jnr, Robert W Hurley, Joel Katz, Jaideep Pandit, Theodore Price, Michael E Schatman, Stephan K W Schwarz, Dennis Turk, Marc Van de Velde, Matthew Wiles, Tony Yaksh, David Yarnitsky","doi":"10.2147/JPR.S381164","DOIUrl":"10.2147/JPR.S381164","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3309-3316"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Kilohertz Frequency Alternating Current with Non-Invasive Electrodes for Treatment of Neuropathic Pain After Spinal Cord Injury: A Randomized, Single-Blind, Sham-Controlled Study.","authors":"Niannian Shuai, Yuyao Zhu, Yao Xiao, Bin Yu","doi":"10.2147/JPR.S528057","DOIUrl":"10.2147/JPR.S528057","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effectiveness and safety of noninvasive kilohertz frequency alternating current (KHFAC) therapy for neuropathic pain in patients following spinal cord injury.</p><p><strong>Methods: </strong>In this randomized, single-blind, sham-controlled trial conducted from June 1, 2023, to January 31, 2024, 50 patients suffering from neuropathic pain post-spinal cord injury were assigned to receive either KHFAC or sham stimulation for 7 days, complemented by twice-daily oral administration of 75 mg pregabalin. Outcomes were assessed using the Visual Analog Scale (VAS), Pittsburgh Sleep Quality Index (PSQI), and Brief Pain Inventory (BPI) at baseline, at the end of treatment, and 30 days post-treatment. The primary outcome was the effective rate at the end of treatment, defined as a decrease in VAS score of 30% or more.</p><p><strong>Results: </strong>At the end of the 7-day treatment period, the experimental group demonstrated a significantly higher response rate, with 60% of participants achieving a 30% or greater reduction in VAS scores compared to 28% in the control group (X²=5.195, P<0.05). During this initial period, KHFAC effectively decreased pain intensity, reduced the frequency of paroxysmal pain, and lessened the need for additional analgesics. It also improved sleep quality and overall quality of life relative to sham stimulation. However, at the 30-day follow-up, no statistically significant differences were observed between the groups.</p><p><strong>Conclusion: </strong>KHFAC is effective and safe for short-term neuropathic pain relief and quality of life enhancement in spinal cord injury patients, without an increase in adverse events versus sham stimulation. However, while reductions in analgesic use suggest potential lasting benefits, the long-term effectiveness remains uncertain. Further studies are required to assess the persistence of these effects.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry, ChiCTR2300068114.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3321-3330"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12228514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Proposed Diagnostic and Treatment Algorithm for the Management of Lumbar Discogenic Pain.","authors":"Morgan P Lorio, Douglas P Beall, Thomas J Myers, Ramana K Naidu, W Porter McRoberts, Timothy T Davis, Emmanuel G Gage, Aaron K Calodney, Paul Verrills, Michael J De Palma, Kasra Amirdelfan, Jon E Block","doi":"10.2147/JPR.S522750","DOIUrl":"10.2147/JPR.S522750","url":null,"abstract":"<p><strong>Background: </strong>There is renewed interest in the intervertebral disc as a target for treatments aimed at ameliorating lumbar discogenic pain by restoring and preserving the natural structure and function of this component of the vertebral motion segment.</p><p><strong>Methods: </strong>Using a modified Delphi methodology involving a panel of 11 experts, we developed a simple, understandable clinical algorithm to serve as a foundation for objective decision making regarding the diagnosis and treatment of lumbar discogenic pain throughout the entire continuum of care. A decision tree approach was utilized with \"either/or\" choices at each branch or node in the algorithm. Clinical activities in this algorithm were divided into examination procedures and corresponding treatment interventions. Corresponding treatment options were designated based on published degenerative disc disease (DDD)-specific clinical practice guidelines and/or meta-analyses.</p><p><strong>Results: </strong>This algorithm recommends a systematic rule set for discogenic pain diagnostic and treatment options. Initially, the presence of lumbar discogenic pain is confirmed via assessment of a series of clinical signs including axial midline back pain (≥ 4 of 10), pain with flexion, sitting intolerance, positive pain provocation with sustained hip flexion, and absence of motor/sensory/reflex changes. Radiographic severity of DDD is graded by modified Pfirrmann grade (1 to 8). Treatment options are stratified by DDD severity to include conservative management (grades 1 and 2), minimally-invasive intradiscal therapies (grades 3 to 7), and more invasive surgical procedures (grade 8). Recognizing that the management program for patients with lumbar discogenic pain can be highly personalized, the treatment options recommended by this algorithm should be considered general guidance.</p><p><strong>Conclusion: </strong>The proposed algorithm offers an easy-to-use clinical tool for identifying, evaluating and treating patients with lumbar discogenic pain. The successful implementation of this algorithm involves an important interplay between advanced practice providers, interventional pain physicians and spine surgeons.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3331-3343"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Call to Action: Elevating Critical Appraisal Training in Pain Medicine.","authors":"David Hao, Derick Davis, Michael E Schatman","doi":"10.2147/JPR.S549345","DOIUrl":"10.2147/JPR.S549345","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"3317-3320"},"PeriodicalIF":2.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}