Journal of Pain Research最新文献

{"title":"Balanced Opioid-Free Anesthesia on Chronic Postsurgical Pain After Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Trial Protocol.","authors":"Wen-Wen Huo, Jia-Yu Qian, Han-Xue Zhao, Wei Dou, Shao-Mu Chen, Fu-Hai Ji, Ke Peng","doi":"10.2147/JPR.S519022","DOIUrl":"10.2147/JPR.S519022","url":null,"abstract":"<p><strong>Background: </strong>Opioids are widely used for anesthesia and postoperative analgesia; however, their use is related to increased risks of untoward effects including hyperalgesia and chronic postsurgical pain (CPSP). We aim to compare opioid-free anesthesia (OFA) with opioid-based anesthesia (OBA) on the incidence of CPSP after video-assisted thoracoscopic surgery (VATS).</p><p><strong>Methods: </strong>This randomized controlled clinical trial was approved by the Medical Ethics Committee of the First Affiliated Hospital of Soochow University, Suzhou, China. A total of 180 adult patients undergoing VATS lung resection will be randomized to receive one of two balanced anesthesia regimens: OFA (dexmedetomidine, esketamine, and sevoflurane) or OBA (sufentanil and sevoflurane). A standardized multimodal analgesia comprises erector spinae plane block, intravenous flurbiprofen axetil, and patient-controlled sufentanil analgesia. The primary outcome is the incidence of CPSP at 3 months after surgery. Secondary outcomes include acute postoperative pain at rest and while coughing (at discharge from post-anesthesia care unit and 6, 24 and 48 hours after surgery), the incidences of postoperative pain at 1 month and 6 months, postoperative 24- and 48-hour sufentanil consumption, adverse events (postoperative nausea and vomiting, headache, dizziness, hallucination, and nightmare), length of post-anesthesia care unit and hospital stay, and the 15-item quality of recovery scores at 48 hours after surgery.</p><p><strong>Discussion: </strong>We hypothesize that the OFA strategy would decrease the incidence of CPSP, reduce postoperative adverse events, and enhance quality of recovery following VATS procedures.</p><p><strong>Registration: </strong>Chinese Clinical Trial Registry (ChiCTR2400081099).</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2459-2466"},"PeriodicalIF":2.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Absorbable Antibacterial Envelope Reduces Surgical Site Infections for Intrathecal Pain Pump Implants: A Retrospective Analysis.","authors":"Christopher L Robinson, Michael C Chiang, Akash S Patel, Kheng Sze Chan, Arti Ori, R Jason Yong, Samuel P Ang","doi":"10.2147/JPR.S519430","DOIUrl":"10.2147/JPR.S519430","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2479-2482"},"PeriodicalIF":2.5,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes Of Intraarticular Corticosteroid Injections into the Cervical Facet Joint Based on Single-Photon Emission Computed Tomography Imaging.","authors":"Seoyon Yang, Min Cheol Chang","doi":"10.2147/JPR.S522930","DOIUrl":"10.2147/JPR.S522930","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic neck pain is a prevalent condition that significantly impairs quality of life and contributes to disability. The cervical facet joint (CFJ) is a common source of neck pain, and intraarticular (IA) corticosteroid injections are widely utilized for symptom relief. However, accurately predicting treatment outcomes remains challenging. This study aimed to evaluate the utility of bone single-photon emission computed tomography (SPECT) in predicting the therapeutic response to IA corticosteroid injections in patients with CFJ-origin neck pain.</p><p><strong>Patients and methods: </strong>A retrospective analysis was conducted on 102 patients who underwent IA CFJ corticosteroid injections between March 2010 and December 2020. Patients were stratified into two groups based on bone SPECT findings: those with increased CFJ radiotracer uptake (SPECT+ group, n=60) and those without (SPECT- group, n=42). Pain intensity was assessed using the numeric rating scale (NRS) before treatment and at the 1-month follow-up. Treatment success was defined as a ≥50% reduction in NRS scores. Statistical analyses were performed to compare outcomes between groups.</p><p><strong>Results: </strong>Both the SPECT+ and SPECT- groups exhibited significant pain reduction following IA corticosteroid injection (<i>P</i> < 0.001 for both groups). However, the SPECT+ group demonstrated significantly greater pain relief compared to the SPECT- group at the 1-month follow-up (<i>P</i> = 0.007). Furthermore, the treatment success rate was significantly higher in the SPECT+ group (63.3%) than in the SPECT- group (38.1%) (<i>P</i> = 0.012).</p><p><strong>Conclusion: </strong>Bone SPECT is a valuable imaging modality for predicting the therapeutic efficacy of IA corticosteroid injections in patients with CFJ-origin neck pain. The findings suggest that increased CFJ radiotracer uptake is associated with a greater likelihood of achieving significant pain relief, underscoring the potential role of inflammation in treatment response.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2453-2458"},"PeriodicalIF":2.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare Workers' Pain Management-Correlated Barriers and Self-Efficacy at Teaching Hospitals in the City of Ismailia.","authors":"Fatma Mohamed Elmansy, Mohamed Goda Elbqry, Saddam Ahmed Al-Ahdal, Fatima S O Ashmieg, Samia Eaid Elgazzar, Patience Osose Nasir, Nasiru Mohammed Abdullahi","doi":"10.2147/JPR.S515344","DOIUrl":"10.2147/JPR.S515344","url":null,"abstract":"<p><strong>Aim: </strong>To determine healthcare workers' pain management-correlated barriers and self-efficacy at teaching hospitals in the city of Ismailia, Egypt.</p><p><strong>Methods: </strong>A descriptive study was enrolled. 117 healthcare workers (nurses and physicians) were recruited through a purposive sampling technique. An online valid closed-ended online questionnaire was used to collect data between June and December 2023 to assess demographic data, pain management-correlated barriers, and self-efficacy.</p><p><strong>Results: </strong>The findings indicated that medical staff, patients and families, and the healthcare system each perceived distinct barriers to care, with mean scores of 4.88 (SD = 0.56), 5.65 (SD = 1.74), and 3.11 (SD = 0.36), respectively. Furthermore, healthcare workers' self-efficacy was found to be moderate, with a mean score of 12.99 (SD = 4.02) A statistically significant difference (p ≤ 0.05) was found in healthcare workers' self-efficacy based on their workplace and years of experience.</p><p><strong>Conclusion: </strong>In the critical care setting, healthcare workers perceived correlated barriers as significant obstacles to successful pain management. High self-efficacy in pain management was reported among healthcare workers in the critical care unit. Effective pain management necessitates specialized training programs that incorporate diverse tools and consider patients' cultural backgrounds. Integrating cultural competence into academic curricula and hospital training programs is vital. Healthcare organizations and policymakers should prioritize addressing the identified barriers to improve healthcare delivery and outcomes.</p><p><strong>Study implication: </strong>Firstly, enhancing pain management practices is crucial in improving patient care. Identifying and addressing the barriers that healthcare professionals face in pain management. Improving healthcare workers' self-efficacy in pain management for consistent and effective care, reducing unnecessary suffering and bridge the gaps to improve overall patient outcomes.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2417-2425"},"PeriodicalIF":2.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Costotransverse Foramen Block with Thoracic Paravertebral Block and Erector Spinae Plane Block for Patients Undergoing Video-Assisted Thoracoscopic Surgery: A Randomized Controlled Non-Inferiority Trial.","authors":"Jing Li, Peiqi Shao, Hong Wen, Danxu Ma, Lina Yang, Jianshuai He, Jia Jiang","doi":"10.2147/JPR.S518558","DOIUrl":"10.2147/JPR.S518558","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the safety and efficacy of costotransverse foramen block for postoperative analgesia in video-assisted thoracoscopic surgery (VATS).</p><p><strong>Patients and methods: </strong>Seventy-five patients undergoing elective VATS under general anaesthesia were recruited to this double-blind, non- inferiority trial and randomized to preoperatively receive a thoracic paravertebral block (TPVB group), a costotransverse foramen block (CTFB group), or an erector spinae plane block (ESPB group) with 0.5% ropivacaine 20 mL at T5 level. The primary outcome was the postoperative numerical rating scale pain score assessed at 6 h. Secondary outcomes included pain scores at other time points, total opioids consumption at 24 h postoperatively, time to first patient-controlled analgesia pump bolus, number of patients requiring rescue analgesia, dermatomal coverage at 30 min after block, time to perform the block, satisfaction scores of the analgesic effect, block-related side effects, and other complications. The health-related quality of life was evaluated one month after surgery.</p><p><strong>Results: </strong>The pain scores at 6 h after surgery were 0 (0, 3) in the TPVB group, 0 (0, 2) in the CTFB group, and 4 (3, 4) in the ESPB group. The 95% CI of median difference was 0 to 0 comparing CTFB with TPVB and -4 to -2 comparing CTFB with ESPB. Both the upper 95% CI limits were lower than the predefined noninferiority margin of 1. The pain scores at postanaesthesia care unit, 1 h, 6 h and 12 h after surgery, number of block dermatomes, patient satisfaction scores, time to perform the block as well as the time to first analgesia pump bolus were significantly different between the CTFB group and ESPB group. No differences were detected in other secondary outcomes.</p><p><strong>Conclusion: </strong>Ultrasound-guided CTFB provided noninferior analgesia compared to TPVB at 6 h after VATS. Additionally, CTFB might provide better analgesia to ESPB although larger confirmatory researches for superiority are further warranted.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2427-2438"},"PeriodicalIF":2.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Low Thoracic Paravertebral Block via the Arcuate Ligament Under Direct Visualization on the Quality of Postoperative Recovery After Laparoscopic Donor Nephrectomy for Living-Donor Kidney Transplantation: Study Protocol for a Prospective, Blinded, Randomized Controlled Clinical Trial.","authors":"Lingli Cui, Yichen Zhu, Shen Liu, Liang Zhang, Qian Zhu, Yun Wang, Danxu Ma","doi":"10.2147/JPR.S516772","DOIUrl":"10.2147/JPR.S516772","url":null,"abstract":"<p><strong>Introduction: </strong>Laparoscopic donor nephrectomy (LDN) is the standard procedure for donor nephrectomy for living kidney transplantation. Compared with traditional open surgery, the laparoscopic techniques have been developed to significantly reduce postoperative pain and accelerate postoperative recovery; however, most donors still experience more than moderate pain after surgery. Ensuring maximum perioperative safety and postoperative pain control for donors remains a top priority for LDN. Our group reported a novel blockade technique that allows local anesthetic to be injected directly to reach the low thoracic paravertebral space under direct laparoscopic observation via the arcuate ligament to achieve somatic and visceral pain analgesia; this technique has been successfully applied to patients undergoing retroperitoneal laparoscopic nephrectomy. We hypothesized that compared with the transversus abdominis plane (TAP) block, low thoracic paravertebral block (TPVB) via the arcuate ligament under direct vision would reduce the consumption of postoperative opioids and improve the quality of postoperative recovery of donors after LDN.</p><p><strong>Methods/analysis: </strong>This study is a prospective blind, randomized, controlled clinical trial with a concealed allocation of donors scheduled to undergo elective LDN 1:1 to receive either a low TPVB via the arcuate ligament under direct vision or a TAP block. This study will recruit a total of 82 living kidney donors. The primary outcome is the 15-item recovery quality scale (QoR-15) score at 24 hours after surgery.</p><p><strong>Ethics and dissemination: </strong>This trial was approved by the Ethics Committee of Beijing Friendship Hospital, Capital Medical University. This trial study protocol was approved on 30 November 2024. The trial started recruiting patients after being registered on the Chinese Clinical Trial Registry.</p><p><strong>Trial registration number: </strong>ChiCTR2400094612.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2409-2416"},"PeriodicalIF":2.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five Critical Queries on Network Meta-Analysis: \"Effective Yet Insignificant\" Manipulative Therapy for Myofascial Pain Syndrome? [Letter].","authors":"Zhongtian Chen, Shangdong Li, Renyu Yang, Ruimin Liu","doi":"10.2147/JPR.S533698","DOIUrl":"10.2147/JPR.S533698","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2407-2408"},"PeriodicalIF":2.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic and Clinical Evaluation of Lever-Positioning Manipulation in Lumbar Disc Herniation: A Study Protocol for a Randomized Controlled Trial Using Rs-fMRI.","authors":"Yunxing Xie, Honggen Du, An Liang, Juncheng Yao, Jianpeng Qu, Xiayang Zeng","doi":"10.2147/JPR.S523613","DOIUrl":"10.2147/JPR.S523613","url":null,"abstract":"<p><strong>Background: </strong>Lumbar disc herniation (LDH) is a prevalent clinical chronic pain disorder characterized by low back pain, lower limb pain, numbness, and claudication, among other symptoms. Lever positioning manipulation (LPM) has been demonstrated to alleviate pain by stimulating the paraspinal muscles and improving vertebral mechanical balance. Additionally, it has been shown to influence functional changes in the brain by acting on lumbar vertebral proprioceptors.</p><p><strong>Patients and methods: </strong>This was a randomized controlled study in which 60 eligible participants were randomly assigned to one of three groups: an observation group (LPM group), a control group (Inclined plate manipulation (IPM) group) and a normal control group (No Intervention Group). The ratio of participants in each group was 1:1:1. The LPM and IPM groups received treatment for five sessions per week over two weeks. The control group did not receive any form of intervention. The primary observation was rs-fMRI imaging of functional brain areas, whereas the secondary observations included surface electromyography, lumbar proprioceptive function, and VAS and JOA scores. All of these parameters were assessed before and after treatment. All analyses were conducted in accordance with the principles of treatment. Once data collection is complete, data will be analysed using SPSS 20.0 with ANOVA and rank-sum tests for comparisons. We will conduct follow-up monitoring at the first and third month after the end of treatment.</p><p><strong>Conclusion: </strong>The objective of this study was to observe the changes in the relevant brain regions of LDH patients through LPM treatment of LDH patients, combined with rs-fMRI and lumbar proprioceptor detection, to elaborate the neural pathways of cortical changes, and to provide new ideas and methods for the treatment of LDH.</p><p><strong>Registration for trial: </strong>Chinese Clinical Trial Registry ChiCTR2400082255 on 25 March 2024.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2379-2392"},"PeriodicalIF":2.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Therapeutic Efficacy of Entrapment Neuropathy Unties (ENU) Pharmacopuncture in Neuropathic Pain Caused by Sciatic Nerve Ligation in Mice.","authors":"Bitna Kweon, Dong-Uk Kim, Kyoungsu Park, Sangho Lee, Yousuk Youn, Hyeok Ju Park, Hyun Soo Shim, Junsang Yoo, Yong Kyu Lee, Gi-Sang Bae, Youngjin Choi","doi":"10.2147/JPR.S519298","DOIUrl":"10.2147/JPR.S519298","url":null,"abstract":"<p><strong>Background: </strong>Neuropathic pain caused by peripheral nerve injury results from abnormal signaling or processing in the nervous system. Pharmacopuncture with Entrapment Neuropathy Unties (ENUs), a multi-herbal formulation, may offer a complementary therapeutic strategy. However, its efficacy has not been scientifically validated in vivo.</p><p><strong>Methods: </strong>A mouse model of sciatic nerve ligation (SNL)-induced neuropathic pain was used. Behavioral assessments were performed using Von Frey filaments to measure mechanical allodynia. Immunofluorescence staining was conducted to detect C-FOS and GFAP expression in the spinal dorsal horn. Quantitative PCR (qPCR) was used to evaluate the expression of inflammatory markers, including Gfap, Iba1, Tnf-α, and Il-1β.</p><p><strong>Results: </strong>Local administration of ENUs at the injury site significantly alleviated mechanical allodynia induced by SNL (*p < 0.05, **p < 0.01, ***p < 0.001). Treatment with ENUs also led to statistically significant reductions in the expression of C-FOS, GFAP, and pro-inflammatory cytokines (*p < 0.05, **p < 0.01, ***p < 0.001). Among the treatment groups, the ENU V2-middle and V2-high dose groups demonstrated the most pronounced therapeutic effects compared to the saline-treated control group.</p><p><strong>Conclusion: </strong>This study provides the first in vivo evidence supporting the analgesic and anti-inflammatory effects of ENUs in neuropathic pain. ENUs may exert these effects by suppressing glial activation and neuronal sensitization. Further research is warranted to explore its clinical applications and underlying molecular mechanisms.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2393-2405"},"PeriodicalIF":2.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Commentary on Acupoints for Headache with Blood Stasis Syndrome: A Literature Study Based on Data Mining Technology [Letter].","authors":"Yaling Zheng, Yujun He, Yi Xu","doi":"10.2147/JPR.S536187","DOIUrl":"10.2147/JPR.S536187","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"2373-2374"},"PeriodicalIF":2.5,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12071737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}