Journal of Pain Research最新文献

{"title":"Day-to-Day Risk and Resilience Factors in the Context of Pediatric Post-Surgical Recovery - A Network Analysis of Intensive Longitudinal Data From Adolescents Undergoing Spinal Fusion Surgery and Their Parents.","authors":"Jenny Thorsell Cederberg, Amani Lavefjord, Felicia T A Sundström, Sara Laureen Bartels, Vendela Zetterqvist, Rikard K Wicksell, Lance McCracken, Liesbet Goubert","doi":"10.2147/JPR.S501009","DOIUrl":"10.2147/JPR.S501009","url":null,"abstract":"<p><strong>Objective: </strong>Ineffective pediatric post-operative pain management increases the risk of Chronic Post-Surgical Pain (CPSP), affecting around 20% of children undergoing major surgery. Psychological predictors of recovery, in both children and their parents, have been identified. However, how these variables change throughout the recovery process remains unclear. The aim of the present study was to investigate the associations of adolescent and parental risk and resilience variables in everyday life, during post-operative recovery, for adolescents undergoing spinal fusion surgery.</p><p><strong>Methods: </strong>Participants were adolescents with Idiopathic Scoliosis (AIS), aged 12-18 years, undergoing spinal fusion surgery, and their parents, recruited at four hospitals in Belgium. Participants completed daily assessments for 7 consecutive days, at 5 time-points, before surgery, and at 3 and 6 weeks, and 6 and 12 months, post-surgery. Diary measures included adolescent and parental pain and recovery variables known to be relevant in the context of pediatric post-operative pain. Network analysis was used to explore correlations between all variables throughout the post-operative recovery process.</p><p><strong>Results: </strong>The sample comprised N=190 participants. Associations were stronger <i>within</i> adolescent and parent variables, than <i>between</i> them. For adolescents, psychological flexibility was associated with positive mood and activity engagement, and pain intensity with pain catastrophizing and activity avoidance. For parents, higher levels of pain-related fear and catastrophizing were related to more parent-to-child instructions to avoid activities. Regarding adolescent-parent <i>between</i> correlations, parental instructions to avoid activities were associated with adolescent physical complaints and activity avoidance, and parent pain catastrophizing was associated with adolescent pain-related fear and catastrophizing. Generally, networks displayed both similarities and differences across post-operative phases.</p><p><strong>Discussion: </strong>The study sample was small in relation to the statistical analyses conducted. Even so, the present findings provide a new perspective on psychological predictors at play in everyday life throughout the pediatric post-operative recovery process, indicating important targets, both clinical and for future investigation.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1545-1561"},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetically Supported Causality Between Immune Cells Traits and Low Back Pain: A Bi-Directional Two-Sample Mendelian Randomization Study.","authors":"Jianbing Wang, Mengye Zhu, Yuhan Liu, Daying Zhang, Shuchun Yu, Jinjin Zhang","doi":"10.2147/JPR.S493766","DOIUrl":"10.2147/JPR.S493766","url":null,"abstract":"<p><strong>Purpose: </strong>Prior studies have suggested that immune cells play a crucial role in Low Back Pain (LBP). We employed a bi-directional Mendelian randomization (MR) study to investigate the causal relationship of immune cells with the risk of LBP.</p><p><strong>Patients and methods: </strong>Single Nucleotide Polymorphisms (SNPs) that had a significant genetic association with immune cells were used as instrumental variables (IVs). The inverse variance weighted (IVW) method was used as the primary approach for MR analyses. To assess the robustness, sensitivity analyses were further performed using MR-Egger and MR-PRESSO.</p><p><strong>Results: </strong>The MR analysis revealed a causal relationship between six types of immune cells and LBP (<i>P</i> < 0.05), including CD4 Treg AC (OR, 0.925; 95% CI, 0.878-0.974; <i>P</i> = 0.003), CD19 on CD20^- CD38^- (OR, 0.938; 95% CI, 0.898-0.979; <i>P</i> = 0.003), CD4 on HLA DR⁺ CD4⁺ (OR, 0.947; 95% CI, 0.909-0.987; <i>P</i> = 0.010), CD25 on CD39⁺ CD4⁺ (OR, 0.954; 95% CI = 0.922-0.988; <i>P</i> = 0.008), CD14 on CD33br HLA DR⁺ CD14^dim (OR, 0.950; 95% CI = 0.916-0.985; <i>P</i> = 0.006), and CD4RA on TD CD4⁺ (OR, 1.030; 95% CI, 1.012-1.048; <i>P</i> = 0.001). Reverse MR analysis found no evidence of potential causal effects of genetically predicted LBP on the six types of immune cells.</p><p><strong>Conclusion: </strong>This study has demonstrated a close genetic connection between immune cells and LBP, providing valuable insights for future clinical research.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1577-1585"},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Carotid Interventions on Headache Relief in Patients with Carotid Stenosis: a Retrospective Analysis of Carotid Endarterectomy Versus Stenting.","authors":"Oguz Arslanturk, Ali Kemal Gur, Fatih Ada, Emrah Keskin","doi":"10.2147/JPR.S511101","DOIUrl":"10.2147/JPR.S511101","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of carotid endarterectomy (CEA) and carotid artery stenting (CAS) on postoperative headache outcomes in patients with carotid artery stenosis, comparing changes in pre-existing headache intensity and the incidence of new-onset headaches.</p><p><strong>Materials and methods: </strong>We conducted a retrospective cohort analysis on 284 patients who underwent CEA (n=167) or CAS (n=117) between January 2018 and December 2023. Pre- and postoperative headache characteristics were documented at baseline and 24 h, 1 month, and 6 months after the intervention. We evaluated headache frequency, intensity (using the Numeric Rating Scale [NRS]), and duration while focusing on changes in pre-existing headaches and the incidence of new headaches.</p><p><strong>Results: </strong>Patients who underwent CEA had a greater reduction in headache intensity at 24 h (NRS median 4, Interquartile range [IQR]: 2-6) compared with those who underwent CAS (NRS median 6, IQR: 2-7; p=0.038). At 1 month, the CEA group continued to show lower headache scores (median 2, IQR: 1-3) compared with the CAS group (median 3, IQR 2-4; p=0.045). At 6 months, both groups had similar levels of headache resolution (p=0.785). Patients who underwent CAS had higher incidences of new-onset headache than those with CEA at 24 h (34.1% vs 20.3%; p=0.033) and 1 month (26.4% vs 13.1%; p=0.018), but converged by 6 months.</p><p><strong>Conclusion: </strong>This study highlights the differential impacts of CEA and CAS on headache outcomes, with CEA showing a lower incidence and intensity of postoperative headaches. These findings underscore the need to consider patient-reported symptoms in treatment planning to enhance the quality of life. Further prospective research is essential to corroborate these observations and explore the mechanisms underlying headache outcomes after carotid interventions.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1587-1596"},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Causal Relationship Between Immune Cells and Neuropathic Pain: A Two-Sample Mendelian Randomization Study Based on Genome-Wide Association Analysis.","authors":"Wangyu Li, Rongguo Liu","doi":"10.2147/JPR.S511182","DOIUrl":"10.2147/JPR.S511182","url":null,"abstract":"<p><strong>Purpose: </strong>Increasing evidence indicates that various types of immune cells are associated with different forms of neuropathic pain (NP). However, the causal relationships among these associations remain unclear. To elucidate the causal relationships between immune cells and NP, we conducted a two-sample Mendelian randomization (MR) analysis.</p><p><strong>Patients and methods: </strong>The exposure and outcome Genome-wide association analysis (GWAS) data used in this study were obtained from open-access databases. This study employed a two-sample MR analysis to evaluate the causal relationships between 731 immune cell traits and four types of NP, including postherpetic neuralgia (PHN), trigeminal neuralgia (TN), diabetic peripheral neuropathy (DPN), and drug-induced peripheral neuropathy (DIPN).</p><p><strong>Results: </strong>The relative count of CD39+ CD4+ %T cells was positively associated with TN, while the mean fluorescence intensity (MFI) of CD20 on IgD+ CD38br (B cell) and forward scatter area (FSC-A) on myeloid dendritic cells (DCs) were negatively associated with TN. Additionally, the relative count of CD8br NKT %lymphocytes was positively associated with PHN, and the MFI of HLA DR on CD33br HLA DR+ CD14 (myeloid cells) was negatively associated with PHN. The MFI of CD4 on activated and secreting T regulatory (Treg) cells was positively associated with DPN. Furthermore, the relative count of B cell % CD3- lymphocytes was negatively associated with DIPN.</p><p><strong>Conclusion: </strong>This MR study, using genetic data from individuals of European descent, provides evidence supporting the causal relationships between several specific immune cell phenotypes and various NP subtypes.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1515-1523"},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Circulating Inflammatory Cytokines and Neuropathic Pain: A Two-Sample Mendelian Randomization Study.","authors":"Yihan Zheng, Hongmei Wang, Huale Zhang, Xizhu Wu, Min Zhou, Wang Denggui","doi":"10.2147/JPR.S495896","DOIUrl":"10.2147/JPR.S495896","url":null,"abstract":"<p><strong>Purpose: </strong>Several recent observational studies have reported that the circulating inflammatory cytokine composition is associated with neuropathic pain. However, the causal effect of 41 circulating inflammatory cytokines on neuropathic pain is unknown.</p><p><strong>Patients and methods: </strong>A two-sample Mendelian randomization study was performed using summary statistics for a genome-wide association study (GWAS) of circulating inflammatory cytokines conducted within three Finnish cohorts (YFS and FINRISK 1997 and 2002, n=8,293). The summary statistics of neuropathic pain were obtained from the GWAS dataset (800 patients and 195,047 controls). Inverse variance weighting, weighted median weighting, MR‒Egger regression, simple weighting, and weighted weighting were used to examine the causal associations between inflammatory cytokines and neuropathic pain. Sensitivity analyses, including the Cochran Q test, Egger intercept test, and leave-one-out analysis, were performed to verify the robustness of the MR results.</p><p><strong>Results: </strong>Inverse variance weighted estimates suggested that <i>G-CSF</i> (OR=0.57, 95% CI=0.39-0.83, <i>P</i>=3.4e-03), <i>IL-16</i> (OR=0.73, 95% CI=0.55-0.96, <i>P</i>=2.7e-02), and <i>IL-1β</i> (OR=0.57, 95% CI=0.33-0.99, <i>P</i>=4.4e-02) had protective effects on neuropathic pain. In addition, <i>IP-10</i> (OR=1.36, 95% CI=1.06-1.74, <i>P</i>=1.5e-02) was suggested to be associated with neuropathic pain. No significant heterogeneity of instrumental variables or horizontal pleiotropy was found.</p><p><strong>Conclusion: </strong>This two-sample Mendelian randomization study revealed that <i>G-CSF, IL-16, IL-1β, and IP-10</i> were causally associated with neuropathic pain. This knowledge could guide future research in developing more effective treatments for neuropathic pain, potentially leading to better pain management options for patients.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1525-1544"},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Link Between Diabetes, Herpes Zoster, and Post-Herpetic Neuralgia: Insights From Mendelian Randomization.","authors":"Xueying Yang, Dairui Li, Yuqing Chen, Xuerong Zhang, Qiong Zhao","doi":"10.2147/JPR.S501674","DOIUrl":"10.2147/JPR.S501674","url":null,"abstract":"<p><strong>Background: </strong>Diabetes mellitus (DM), herpes zoster (HZ) and its sequelae, post-herpetic neuralgia (PHN), are common in elderly individuals. Previous observational studies have shown that the prevalence of HZ and PHN in conjunction with DM is increasing. Nonetheless, few studies have investigated the causal relationships between DM and the risk of HZ and PHN.</p><p><strong>Methods: </strong>A two-sample Mendelian randomization (TSMR) analysis was conducted on genome-wide association study (GWAS) data. We obtained four separate datasets for DM: type 1 diabetes (T1D), type 2 diabetes (T2D), mother diabetes mellitus (mother-DM) and father diabetes mellitus (father-DM), and two independent datasets for HZ and anti-varicella-zoster virus IgG (VZV-IgG), a single GWAS for PHN. The inverse variance weighted (IVW), MR‒Egger, weighted median and weighted mode analyses were used to estimate the causality.</p><p><strong>Results: </strong>Genetically predicted T1D increased the level of VZV-IgG (IVW: OR=1.011, 95% CI 1.006-1.016, <i>P</i> _-FDR=8.44×10^-6). T2D (IVW: OR=1.313; 95% CI 1.043-1.655, <i>P</i> _-FDR=0.041), mother-DM (IVW: OR=7.909; 95% CI 1.232-50.777, <i>P</i> _-FDR=0.039), and father-DM (IVW: OR=11.798; 95% CI 2.051-67.874, <i>P</i> _-FDR=0.023) increased the risk of PHN. No reverse causality was found between HZ, PHN, and DM.</p><p><strong>Conclusion: </strong>Our research reveals a causal link between genetically determined T1D and increased VZV-IgG levels. Additionally, genetically predicted T2D and a family history of DM increase the risk of PHN. These discoveries deepen our comprehension of the underlying causes of HZ and PHN.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1479-1489"},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperalgesic Priming in the Transition From Acute to Chronic Pain: Focus on Different Models and the Molecular Mechanisms Involved.","authors":"Mi Zhang, Ningbo Li, Shuai Zhao, Xiaobo Feng","doi":"10.2147/JPR.S514851","DOIUrl":"10.2147/JPR.S514851","url":null,"abstract":"<p><p>Poorly treated acute pain can develop into chronic pain, resulting in significant impairment of patients' quality of life. The hyperalgesic priming model is commonly used to study how acute pain transforms into chronic pain. Inflammatory factors, small molecules, opioid receptor agonists, chemotherapy drugs, and stress serve as initiating factors in the hyperalgesic priming model. Various signaling pathways such as PKCε, MOR and ephrin-B2 pathways, and sexual differences also contribute to the transformation process of chronic pain. In this review, we examine various hyperalgesic priming models and their underlying molecular mechanisms. By thoroughly investigating these molecular mechanisms, researchers can more precisely identify the critical nodes involved in pain transformation, thereby developing more targeted treatment strategies.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1491-1501"},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are Chronic Pain Fellowships Disguised as Acute Pain Fellowships Which Manage Chronic Pain? How to Recognize and Repair.","authors":"Sayed E Wahezi, Ugur Yener, Miles Day, Peter S Staats, Christopher Gilligan, Michael E Schatman, Scott G Pritzlaff","doi":"10.2147/JPR.S525154","DOIUrl":"10.2147/JPR.S525154","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1511-1514"},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Addition of Intrathecal Clonidine to Reduce Medication-Related Side-Effects in Cancer Pain: A Retrospective Cohort Study.","authors":"Evgeny Bulat, Rahul Chaturvedi, Peyton Johnson, Neal Rakesh, Amitabh Gulati","doi":"10.2147/JPR.S504556","DOIUrl":"10.2147/JPR.S504556","url":null,"abstract":"<p><strong>Objective: </strong>Compared to conventional medical management, targeted drug delivery provides superior cancer pain management with fewer side-effects and potentially improved survival. Intrathecal (IT) clonidine has been used off-label to improve analgesia in patients with cancer pain, but evidence regarding safe dosing in this patient population is limited. This study evaluates the impact of adding IT clonidine on pain, opioid consumption, and the prevalence of medication-related side-effects. It also provides initial dosing recommendations for cancer pain.</p><p><strong>Materials and methods: </strong>This was a retrospective chart review conducted at a single academic cancer center. Medical records between 2012 and 2022 were queried for patients who had an intrathecal pump (ITP). Patients' charts were reviewed prior to starting IT clonidine, at the IT clonidine start date, at 1-3 months follow-up, and at over three months follow-up. Primary outcomes included the visual analog scale (VAS) score and daily systemic morphine milligram equivalents (MME). Secondary outcomes included IT or systemic medication side-effects and the daily doses of concurrent IT opioids and local anesthetic (LA).</p><p><strong>Results: </strong>Eighteen patients were included. No significant change in VAS or systemic MME was observed at follow-up after starting IT clonidine. Median daily IT bupivacaine and opioids with or without patient-controlled boluses significantly rose by the first follow-up; by the second follow-up, only IT opioids were elevated. There was a trend towards a lower prevalence of medication-related side-effects across follow-up periods. On post-hoc logistic regression analysis, IT clonidine dosing was the sole significant predictor of side-effect prevalence. Higher IT clonidine dosing was associated with a lower likelihood of side-effects. Initial IT clonidine doses of 40-60 mcg/day were associated with a 50-75% reduced probability of side-effects.</p><p><strong>Conclusion: </strong>While its role in reducing pain and systemic opioids is complex, IT clonidine may have a beneficial role in mitigating medication-related side-effects from systemic opioids, IT opioids, or LA for cancer pain. IT clonidine may be safely initiated at doses of 40-60 mcg/day for this indication.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1503-1509"},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Analgesic Mechanisms of Acupuncture for Cancer Pain: Insights From Multimodal Bioelectrical Signal Analysis.","authors":"Jianhao Huang, LiuYang Zhao, YuFeng Xie, Chi Wang, XinJing Yang, HaiFu Huang, Dian Zhang","doi":"10.2147/JPR.S503975","DOIUrl":"10.2147/JPR.S503975","url":null,"abstract":"<p><strong>Purpose: </strong>Cancer pain management remains a significant clinical challenge. While acupuncture has shown potential in alleviating cancer pain, its underlying mechanisms are not yet fully understood. This study investigates the neurophysiological mechanisms underlying acupuncture's analgesic effects using multimodal bioelectrical signal analysis.</p><p><strong>Patients and methods: </strong>Fifteen cancer pain patients underwent acupuncture while wearing portable, multi-sensor devices to capture bioelectrical signals. Pain levels were assessed using the Numerical Rating Scale (NRS) before and during needle retention. Neurophysiological changes were evaluated using Principal Component Analysis, Joint Time-Frequency Analysis, power spectrum analysis, spectral analysis, and dynamic functional network analysis.</p><p><strong>Results: </strong>There was a significant reduction in NRS scores from pre-treatment to the retention period, indicating pain relief. Principal component analysis showed significant differences in bioelectrical signals between these periods. Power spectrum analysis revealed decreased signal power during retention. Functional network analysis demonstrated a reduction in connectivity strength between electroencephalography and electromyography signals. Spectral analysis identified distinct real-time and staged characteristics of bioelectrical signals, with correlation analysis confirming a positive relationship between NRS score changes and bioelectrical signal alterations.</p><p><strong>Conclusion: </strong>Acupuncture alleviates cancer pain by reducing functional connectivity between injured tissues and the brain, with immediate effects. Prolonging needle retention may enhance therapeutic outcomes. These findings provide new insights into the neurophysiological basis of acupuncture's analgesic effects, supporting its role in cancer pain management.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1435-1450"},"PeriodicalIF":2.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}