Journal of Pain Research最新文献

{"title":"Targeting Inflammatory Cell Death: A Strategy for Discogenic Pain Relief.","authors":"Li Wang, Yuheng Zhang, Huaqiang Tao, Chao Jiang, Wenlong Chen, Tianrui Chen, Rui Luo, Yufan Wang, Jinhao Dong, Xiaohan Hu, Weibing Si, Chengyong Gu, Xing Yang","doi":"10.2147/JPR.S583691","DOIUrl":"https://doi.org/10.2147/JPR.S583691","url":null,"abstract":"<p><p>Low back pain caused by intervertebral disc degeneration (IVDD) remains a major challenge in clinical management, and its underlying mechanisms have not yet been fully elucidated. Beyond apoptosis, recent studies have shown that pyroptosis, ferroptosis, and necroptosis-as key inflammatory programmed cell death pathways-actively contribute to the pathological progression of IVDD and the development of pain. Currently, effective clinical solutions for discogenic pain are still lacking. This review systematically elaborates on the mechanisms of pyroptosis, ferroptosis, and necroptosis, and explains their activation in different anatomical regions of the intervertebral disc (nucleus pulposus, annulus fibrosus, and endplate). These processes promote pain by altering the local microenvironment, such as through the release of inflammatory factors and the disruption of tissue structure. Furthermore, the article summarizes potential therapeutic strategies targeting these specific cell death pathways, including molecular inhibitors, natural compounds (eg, hesperidin, melatonin), and traditional formulations, with a focus on their prospects for alleviating IVDD-related pain by modulating core cell death mechanisms. By systematically reviewing these novel cell death mechanisms and related therapeutic strategies, this work aims to provide new insights and evidence for the clinical management of discogenic pain.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"583691"},"PeriodicalIF":2.5,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13123556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trigger Point Electrical Dry Needling with Different Waveforms Plus Intra-Articular Corticosteroid for Knee Osteoarthritis: A Prospective Randomized Controlled Trial.","authors":"Yulian Lin, Wensen Jia, Chang Liu, Yujia Tang, Yan Yuan","doi":"10.2147/JPR.S595268","DOIUrl":"https://doi.org/10.2147/JPR.S595268","url":null,"abstract":"<p><strong>Background: </strong>Knee osteoarthritis is a common musculoskeletal disorder associated with pain, functional limitation, and substantial healthcare burden.</p><p><strong>Purpose: </strong>To compare the efficacy of trigger point electrical dry needling (electrical-DN) with different waveforms, combined with intra-articular corticosteroid injection (CSI), in patients with knee osteoarthritis (KOA).</p><p><strong>Methods: </strong>A total of 138 participants were randomized to the sham stimulation group (Group S), dense-disperse wave group (Group D), or continuous wave group (Group C). All groups received a single CSI. Group S had no electrical stimulation, while Group D and Group C were treated with dense-disperse wave and continuous wave, respectively. Electrical stimulation was administered for 20 minutes per session, once weekly for two weeks. Assessments were obtained at the following time points: baseline, post-treatment weeks 1, 4, 8, and 12. Clinical outcomes were assessed using the numerical rating scale (NRS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Short-Form McGill Pain Questionnaire (SF-MPQ), Pittsburgh Sleep Quality Index (PSQI), Hamilton Anxiety Rating Scale (HAMA), Knee Flexion Range of Motion (FROM), rescue medication use, and adverse events. Repeated measures were analyzed using generalized estimating equations (GEE), and other comparisons were performed using appropriate parametric or nonparametric tests.</p><p><strong>Results: </strong>Group D showed lower NRS scores than Group C at weeks 8 and 12 and a lower WOMAC score at week 12 (all <i>P</i> < 0.05). Compared with Group S, both electrical-DN groups showed lower NRS and WOMAC scores at all follow-up time points. At week 1, both electrical-DN groups also showed lower SF-MPQ scores and greater improvement in FROM than Group S (all <i>P</i> < 0.05). In GEE analysis, with Group S and week 12 as the reference categories, both Group D (β = -1.152, 95% CI: -1.560 to -0.744) and Group C (β = -0.652, 95% CI: -1.033 to -0.271) showed lower NRS scores at week 12.</p><p><strong>Conclusion: </strong>Trigger point electrical dry needling may provide additional benefit in pain relief for patients with KOA when used after CSI. Among the two electrical-DN groups, the dense-disperse waveform was associated with a modest advantage in pain relief at later follow-up time points.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"595268"},"PeriodicalIF":2.5,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations for a Mind-Body Program for Latine Adults with Chronic Pain and Cognitive Impairment: A Qualitative Study with Healthcare Providers.","authors":"Natalia Giraldo-Santiago, Marlene E Cardoza, Esther E E Estey, Yoojee Kim, Nicolás A Alvarez-Frank, Tony V Pham, Zev Schuman-Olivier, Ana-Maria Vranceanu, Jonathan Greenberg","doi":"10.2147/JPR.S593433","DOIUrl":"10.2147/JPR.S593433","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic pain and cognitive impairment often co-occur and exacerbate each other, with Spanish-speaking Latine adults exhibiting a high prevalence of such comorbidity. While mind-body interventions for this comorbidity show promise, available programs are not tailored to the linguistic and cultural needs of socio-economically disadvantaged Latine adults with cognitive impairment. This study gathered recommendations from healthcare providers to tailor mind-body programs for Latine adults with chronic pain and cognitive impairment.</p><p><strong>Methods: </strong>We conducted six qualitative focus groups with 21 providers and support staff across various healthcare centers. Providers offered their perspectives on the needs, barriers, and general recommendations on tailoring mind-body skills for Spanish-speaking adults with chronic pain and cognitive impairment. We conducted thematic analysis using a hybrid deductive-inductive approach.</p><p><strong>Results: </strong>Within the needs and barriers domain, providers highlighted the importance of targeting multi-morbidities (pain, depression, anxiety, cognitive impairment, sleep disturbances), as well as social and structural factors (isolation, economic hardships, and invalidation of pain and memory-related concerns). Within the socio-cultural considerations for mind-body programs domain, providers perceived skills as a privilege rather than as socio-culturally embedded. They noted difficulties understanding, relating to, and practicing skills due to patient's limited educational backgrounds, health literacy, and support. Within the recommendation's domain, there was a preference for in-person, group-based approaches and programs involving family members to support practice at home. Providers emphasized that while many Latine adults with cognitive impairment remain largely independent, flexible delivery models with varying levels of social support are critical for sustaining skills.</p><p><strong>Conclusion: </strong>Interventions grounded in community connection, family engagement, and culturally meaningful delivery may better align with how Latine individuals navigate their health journeys with chronic pain and cognitive impairment. By centering pain care within relational and community contexts, the present study offers guidance for enhancing mind-body programs to better support engagement, pain management, and cognitive health among Spanish-speaking Latine adults at elevated risk for dementia.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"593433"},"PeriodicalIF":2.5,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: A Cross-Sectional Survey on Musculoskeletal Pain Among Professional and Non-Professional Gamers in Saudi Arabia: Associations with Gaming Genre, Duration, and Ergonomic Factors [Corrigendum].","authors":"","doi":"10.2147/JPR.S615617","DOIUrl":"https://doi.org/10.2147/JPR.S615617","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2147/JPR.S557124.].</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"615617"},"PeriodicalIF":2.5,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological Characteristics of Pain Among Rowers: A Retrospective Questionnaire Study.","authors":"Huiru Ma, Ziwen Mu, Hanyan Yan, Tingxv Zhang, Haoxiang Wang, Zhiqiang Han, Kazuhiro Imai, Xiao Zhou, Hongtao Zeng","doi":"10.2147/JPR.S593902","DOIUrl":"https://doi.org/10.2147/JPR.S593902","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to analyze the distribution, incidence, and high-risk technical phases of pain among rowers aged 12-24 in China.</p><p><strong>Methods: </strong>In 2024, a retrospective questionnaire survey was performed among 207 rowers. The questionnaire comprised four sections: (1) basic information; (2) rowing-related injury sites over the past year; (3) rowing-related pain sites over the past year; and (4) body locations of pain during rowing strokes in the past year and the specific technical phase when pain occurred. Pain was defined as any painful physical discomfort occurring while maintaining athletic capability. Rowing-related pain rate was standardized to rates per 1000 training sessions and per 1000 training hours, calculated using the Poisson distribution based on sex.</p><p><strong>Results: </strong>The overall pain rate was 24.2%, with 118 reported pain instances. The most common site was the lower back (16.1%), followed by the thigh and shoulder joint. The pain rate per 1000 training sessions was 1.94 (95% CI: 1.59-2.29), and per 1000 training hours was 0.41 (95% CI: 0.34-0.49). Both lower back and knee pain were significantly associated with the risk of shoulder pain. During rowing, approximately half of the athletes reported lower back pain, predominantly occurring during the drive phase.</p><p><strong>Conclusion: </strong>Approximately one-quarter of Chinese rowers experienced pain during training, with low back pain being the most commonly reported. Both lower back and knee pain are significantly associated with shoulder pain risk; and pain during rowing most frequently occurs in the drive phase. This study provides a theoretical basis for enhancing early injury prevention, optimizing athletic performance, and guiding.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"593902"},"PeriodicalIF":2.5,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcutaneous Electrical Acupoint Stimulation for Opioid Tolerance in Hepatocellular Carcinoma and Proteomics Analysis: A Randomized Controlled Trial Protocol.","authors":"Zhihui Luo, Huangan Wu, Jiaxi Pan, Hui-Rong Liu, Yan Huang, Hongxiao Xu, Qingyi Wang, Luyi Wu, Lu Zhu","doi":"10.2147/JPR.S595927","DOIUrl":"https://doi.org/10.2147/JPR.S595927","url":null,"abstract":"<p><strong>Background: </strong>The current method for managing opioid tolerance is opioid rotation, but its effectiveness is limited. Transcutaneous electrical acupoint stimulation (TEAS) combined therapy has been shown to effectively relieve moderate-to-severe pain in patients with hepatocellular carcinoma (HCC), but there is insufficient evidence regarding its role in modulating opioid tolerance. Additionally, exosomal proteomics can aid in exploring the potential mechanisms of action of TEAS.</p><p><strong>Methods: </strong>This single-center, patient-blinded, randomized controlled clinical trial will enroll 72 participants with moderate-to-severe cancer pain secondary to HCC. Participants will be randomly assigned to the observation group or the control group in a 1:1 ratio. On the basis of conventional Western medical analgesia, the observation group will receive TEAS treatment, while the control group will receive sham TEAS treatment. The treatment course will last for 2 weeks, followed by a 4-week follow-up period. The primary outcome is the opioid tolerance index after the treatment concludes in week 2. It quantitatively reflects the degree of opioid tolerance by measuring changes in opioid consumption over time. Secondary outcomes include the Numerical Rating Scale score, numbers of breakthrough pain, frequency of gastrointestinal side effects, quality of life evaluation, and protein biomarkers.</p><p><strong>Conclusion: </strong>The expected results will clarify the efficacy of TEAS in alleviating opioid tolerance in patients with moderate-to-severe HCC-related pain. Exosome proteomics can provide exploratory insights into potential mechanisms underlying the efficacy of TEAS.</p><p><strong>Ethics and trial registration: </strong>The Research Ethics Committee of the Yueyang Hospital of Integrated Traditional Chinese and Western Medicine has approved the study protocol (No. 2025-045). The trial has been registered with the International Traditional Medicine Clinical Trial Registry (http://itmctr.ccebtcm.org.cn/). Registration number: ITMCTR2025002162. Registered on June 9, 2025.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"595927"},"PeriodicalIF":2.5,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Cognitive Behavioral Therapy Combined with Exercise in Patients with Chronic Pain: A Systematic Review and Meta-Analysis.","authors":"Yi-Zhao Zhang, Biao Yang, Cheng-Hao Jiang, Yu-Xuan Guo, Xin-Xin Lai, Wei-Qiang Zhang, He Zhang","doi":"10.2147/JPR.S599315","DOIUrl":"https://doi.org/10.2147/JPR.S599315","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effects of cognitive behavioral therapy (CBT) combined with exercise on multidimensional outcomes in adults with chronic pain, and to examine whether these effects were sustained at 3-, 6-, and 12-month follow-up.</p><p><strong>Patients and methods: </strong>PubMed, Embase, Web of Science, the Cochrane Library, and PsycINFO were searched from inception to December 30, 2025. Randomized controlled trials (RCTs) comparing CBT combined with exercise versus usual care or other control interventions were included.</p><p><strong>Results: </strong>Thirteen RCTs involving 1679 participants were included. Compared with controls, CBT combined with exercise produced small-to-moderate improvements in pain intensity and functional disability, although heterogeneity was observed across studies. Specifically, significant improvements were observed in pain intensity (SMD = -0.44, 95% CI: [-0.72, -0.16], <i>P</i> = 0.002), functional disability (SMD = -0.41, 95% CI: [-0.68, -0.15], <i>P</i> = 0.002), pain catastrophizing (MD = -4.35, 95% CI: [-7.13, -1.56], <i>P</i> = 0.002), pain self-efficacy (SMD = 0.30, 95% CI: [0.09, 0.51], <i>P</i> = 0.005), fear of movement (MD = -1.87, 95% CI: [-3.02, -0.72], <i>P</i> = 0.001), anxiety (SMD = -0.29, 95% CI: [-0.46, -0.12], <i>P</i> = 0.0007), depression (SMD = -0.27, 95% CI: [-0.42, -0.12], <i>P</i> = 0.0003), and quality of life (PCS: SMD = 0.26, 95% CI: [0.01, 0.50], <i>P</i> = 0.04; MCS: SMD = 0.23, 95% CI: [0.08, 0.38], <i>P</i> = 0.002). No significant improvements were observed in physical performance assessed by the Timed Up and Go Test (TUG) and 6-Minute Walk Test (6MWT). Improvements in pain intensity and functional disability were maintained at 3- and 6-month follow-up, whereas effects on other outcomes were less consistent and were mostly no longer evident at 12 months.</p><p><strong>Conclusion: </strong>CBT combined with exercise is a feasible multidisciplinary strategy for adults with chronic pain, yielding small-to-moderate improvements in pain intensity and functional disability, with benefits maintained at 3- and 6-month follow-up. Cognitive-behavioral outcomes, mental health, and quality of life also improved, but their long-term maintenance was limited. No significant benefits were observed in physical performance. Future research requires standardized CBT-exercise protocols and broader population representation.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"599315"},"PeriodicalIF":2.5,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives on Pain: A Narrative Review of Pain Beliefs, Coping, and Clinical Implications.","authors":"Chandler Pugh, Kristina Snoddy, Reagan Boyett, Halle Bakir, Daniel Cawley, Mary K Piscura","doi":"10.2147/JPR.S603074","DOIUrl":"https://doi.org/10.2147/JPR.S603074","url":null,"abstract":"<p><p>Pain beliefs and coping strategies are often linked to treatment outcomes across various pain conditions, yet their roles are often examined in isolation across specific conditions. This narrative review synthesizes evidence across neuropathic, nociplastic, and nociceptive pain to examine how pain-related beliefs shape coping behaviors, treatment adherence, and clinical outcomes. Guided by the Common Sense Model of Illness, we integrate findings from neurobiological, psychological, and clinical literature to demonstrate how negative pain beliefs, such as fear-avoidance, pain catastrophizing, and lower self-efficacy, have been linked to heightened pain perception, maladaptive coping, reduced adherence, and poorer functional recovery. In contrast, positive pain beliefs emphasizing resilience and self-efficacy are often linked to adaptive coping, improved engagement in care, and more favorable outcomes, in part through modulation of prefrontal, limbic, and descending pain regulatory systems. This review synthesizes findings across diverse patient populations and conditions, with an emphasis on the differences in the various effects of pain beliefs and coping strategies. Across conditions, consistent patterns emerge in which belief-driven processes influence both behavioral and neurophysiological responses to pain. We further highlight gaps in current clinical assessment, particularly the underrepresentation of multidimensional belief constructs in routine care, and discuss implications for multidisciplinary, belief-informed interventions. Targeting pain beliefs through cognitive-behavioral strategies, patient education, and individualized care models represents a critical opportunity to improve adherence, reduce disability, and enhance long-term recovery.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"603074"},"PeriodicalIF":2.5,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13118663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liposomal Bupivacaine Infiltration and Postoperative Pain Outcomes in Lumbar Fusion: A Prospective Randomized Controlled Trial.","authors":"Shi-Jing Zhang, Xin Lu, Tian-Xiao Liu, Qing Liu, Yu-Bo Xie","doi":"10.2147/JPR.S598576","DOIUrl":"https://doi.org/10.2147/JPR.S598576","url":null,"abstract":"<p><strong>Background: </strong>Postoperative pain after lumbar fusion may impair coughing and early mobilization. Whether liposomal bupivacaine provides better analgesia than ropivacaine infiltration in this setting remains unclear.</p><p><strong>Methods: </strong>In this single-center randomized controlled trial, 94 patients undergoing multi-segmental posterior lumbar fusion were randomized to LB+B or RH wound infiltration. Outcomes included resting and cough-induced pain scores, rescue opioid use, recovery and sleep quality, length of stay, and adverse events.</p><p><strong>Results: </strong>The prespecified primary endpoint (24-hour resting VAS) did not differ between groups. In baseline-adjusted longitudinal GEE models, neither the overall treatment effect nor the treatment-by-time interaction was statistically significant for resting or dynamic pain. Model-based estimates indicated only modest between-group differences, which were below commonly cited minimal clinically important difference thresholds. Rescue opioid use over 48 hours was similar between groups, and no differences were observed in rescue analgesia, recovery quality, sleep quality, length of stay, or adverse events.</p><p><strong>Conclusion: </strong>In this randomized trial, LB+B did not show a significant overall analgesic advantage over ropivacaine infiltration and was not associated with opioid-sparing or recovery benefits.</p><p><strong>Clinical trial identifier: </strong>The date of first registration in 19/07/2023 ChiCTR2300073714. https://www.chictr.org.cn/.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"598576"},"PeriodicalIF":2.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13111950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Long-Term ACEI/ARB Use and Postoperative Pain in Hypertensive Patients: A Retrospective Cohort Study and Genetic Validation [Letter].","authors":"Shiyan Ke, Ziyi Wang, Qiang Liu","doi":"10.2147/JPR.S616233","DOIUrl":"https://doi.org/10.2147/JPR.S616233","url":null,"abstract":"","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"19 ","pages":"616233"},"PeriodicalIF":2.5,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}